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chr7:55,259,763-56,878,413

Best TWAS P=7e-27 · Best GWAS P=3.93e-22 conditioned to 0.352

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PSPH	0.19	0.09	lasso	8	0.12	2.5e-14	-7.46	-6.9	5.7e-12	0.18	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ZNF713	0.06	0.02	blup	326	0.03	2.9e-04	-2.90	-5.2	1.5e-07	0.56	0.07	0.84	FALSE
3	GTEx	Adipose Subcutaneous	GBAS	0.18	0.12	enet	16	0.16	1.1e-12	-2.38	-5.9	4.2e-09	0.52	0.98	0.02	FALSE
4	GTEx	Artery Coronary	ZNF713	0.18	0.10	enet	14	0.13	3.7e-05	6.25	5.5	4.7e-08	-0.12	0.05	0.86	FALSE
5	GTEx	Artery Tibial	ZNF713	0.19	0.12	lasso	6	0.15	1.2e-11	6.25	6.7	2.4e-11	-0.22	0.47	0.53	FALSE
6	GTEx	Brain Caudate basal ganglia	GBAS	0.19	0.11	lasso	5	0.07	4.1e-03	7.42	-8.5	1.5e-17	0.53	0.02	0.82	FALSE
7	GTEx	Brain Cerebellum	GBAS	0.24	0.01	lasso	10	0.03	4.6e-02	-7.09	-8.3	1.0e-16	0.54	0.03	0.70	FALSE
8	GTEx	Brain Hypothalamus	GBAS	0.21	0.12	lasso	3	0.08	6.3e-03	8.66	-8.6	1.1e-17	0.46	0.01	0.87	FALSE
9	GTEx	Breast Mammary Tissue	GBAS	0.17	0.05	lasso	5	0.03	1.0e-02	-2.38	-6.1	1.2e-09	0.54	0.04	0.67	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	GBAS	0.17	0.05	lasso	3	0.05	1.1e-02	-7.09	-7.3	3.0e-13	0.57	0.06	0.22	FALSE
11	GTEx	Cells Transformed fibroblasts	GBAS	0.16	0.01	enet	26	0.07	9.2e-06	-2.39	-8.7	2.4e-18	0.80	0.18	0.71	FALSE
12	GTEx	Colon Transverse	CHCHD2	0.20	0.16	enet	15	0.16	3.3e-08	8.25	5.2	1.9e-07	-0.06	0.01	0.99	FALSE
13	GTEx	Colon Transverse	GBAS	0.25	0.08	enet	21	0.12	1.6e-06	8.66	-7.6	2.8e-14	0.57	0.00	0.98	FALSE
14	GTEx	Esophagus Mucosa	CCT6A	0.06	0.03	lasso	2	0.02	1.1e-02	-8.00	-8.0	1.0e-15	0.74	0.13	0.32	FALSE
15	GTEx	Esophagus Mucosa	PSPH	0.11	0.00	enet	24	0.01	4.4e-02	-0.24	-6.4	2.1e-10	0.51	0.07	0.54	FALSE
16	GTEx	Esophagus Muscularis	ZNF713	0.11	0.02	enet	17	0.03	3.8e-03	6.25	6.5	7.4e-11	-0.22	0.11	0.44	FALSE
17	GTEx	Heart Left Ventricle	ZNF713	0.13	0.00	enet	23	0.00	5.5e-01	-2.79	6.2	4.4e-10	-0.29	0.05	0.25	FALSE
18	GTEx	Lung	GBAS	0.07	0.00	lasso	3	0.00	1.9e-01	8.66	-9.3	2.0e-20	0.43	0.00	0.96	FALSE
19	GTEx	Muscle Skeletal	GBAS	0.10	0.02	enet	13	0.05	9.2e-06	-2.38	-6.7	2.3e-11	0.49	0.15	0.84	FALSE
20	GTEx	Nerve Tibial	CHCHD2	0.07	0.04	lasso	5	0.06	9.3e-05	-5.23	5.6	2.5e-08	-0.32	0.10	0.74	FALSE
21	GTEx	Nerve Tibial	GBAS	0.14	0.01	lasso	3	0.04	1.0e-03	8.66	-7.4	1.7e-13	0.45	0.00	0.99	FALSE
22	GTEx	Ovary	SUMF2	0.37	0.01	enet	29	0.07	1.1e-02	1.75	5.8	6.7e-09	-0.54	0.05	0.07	FALSE
23	GTEx	Pancreas	CHCHD2	0.16	0.05	lasso	4	0.04	7.3e-03	8.30	-5.2	1.9e-07	0.42	0.09	0.81	FALSE
24	GTEx	Pancreas	GBAS	0.19	0.05	enet	35	0.07	6.6e-04	-5.80	-7.6	2.9e-14	0.66	0.19	0.52	FALSE
25	GTEx	Prostate	GBAS	0.33	0.08	lasso	8	0.13	3.4e-04	-8.00	-8.9	5.4e-19	0.65	0.11	0.45	FALSE
26	GTEx	Prostate	ZNF713	0.19	0.10	lasso	2	0.07	1.0e-02	6.25	6.4	1.3e-10	-0.28	0.04	0.58	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	GBAS	0.08	0.00	lasso	9	0.01	6.3e-02	8.66	-10.3	7.8e-25	0.67	0.02	0.82	FALSE
28	GTEx	Skin Sun Exposed Lower leg	CHCHD2	0.07	0.09	lasso	5	0.05	3.6e-05	8.25	7.8	5.7e-15	-0.35	0.02	0.98	FALSE
29	GTEx	Skin Sun Exposed Lower leg	GBAS	0.14	0.09	enet	32	0.10	1.3e-08	8.66	-8.0	1.4e-15	0.57	0.00	1.00	FALSE
30	GTEx	Stomach	GBAS	0.19	0.01	enet	26	0.07	3.7e-04	-8.04	-8.4	3.6e-17	0.86	0.13	0.52	FALSE
31	GTEx	Testis	GBAS	0.17	0.03	enet	28	0.09	8.2e-05	8.66	-8.1	6.8e-16	0.68	0.01	0.96	FALSE
32	GTEx	Testis	ZNF713	0.15	0.00	enet	10	0.00	1.9e-01	-7.11	7.5	6.8e-14	-0.52	0.03	0.40	FALSE
33	GTEx	Thyroid	GBAS	0.31	0.14	lasso	9	0.30	1.3e-23	-2.38	-7.8	8.3e-15	0.78	0.71	0.29	FALSE
34	METSIM	Adipose	CCT6A	0.03	0.04	lasso	1	0.03	2.0e-05	-9.67	-9.7	3.9e-22	1.00	0.00	1.00	FALSE
35	METSIM	Adipose	CHCHD2	0.30	0.27	bslmm	256	0.27	4.1e-41	8.46	8.0	1.7e-15	-0.36	0.99	0.01	FALSE
36	METSIM	Adipose	GBAS	0.13	0.05	enet	26	0.10	6.1e-15	-3.12	-6.7	1.8e-11	0.62	0.19	0.81	FALSE
37	METSIM	Adipose	PSPH	0.16	0.13	lasso	15	0.17	2.9e-25	-7.46	-6.6	3.6e-11	0.18	1.00	0.00	FALSE
38	ROSMAP	Brain Pre-frontal Cortex	GBAS	0.17	0.06	lasso	5	0.11	2.7e-14	-9.67	-10.7	7.0e-27	0.86	0.00	1.00	TRUE
39	ROSMAP	Brain Pre-frontal Cortex	CCT6A	0.06	0.01	bslmm	279	0.03	2.4e-04	-3.67	-5.9	4.3e-09	0.32	0.40	0.09	FALSE
40	YFS	Blood	CCT6A	0.03	0.02	lasso	4	0.02	5.5e-06	-9.67	-9.2	3.5e-20	0.98	0.00	1.00	FALSE
41	YFS	Blood	GBAS	0.02	0.01	lasso	6	0.01	2.0e-03	-9.67	-9.2	4.0e-20	0.98	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHCHD2	0.06	0.06	lasso	4	0.06	1.8e-05	8.43	8.5	2.7e-17	-0.41	0.57	0.02	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	GBAS	0.05	0.03	blup	48	0.04	2.8e-08	-8.00	-8.9	4.0e-19	0.84	0.18	0.80	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC389493	0.03	0.01	blup	32	0.02	7.3e-05	-7.09	-7.6	2.4e-14	0.57	0.02	0.04	FALSE
45	The Cancer Genome Atlas	Breast Invasive Carcinoma	PSPH	0.03	0.00	enet	6	0.02	3.8e-05	1.89	-8.4	3.0e-17	0.66	0.05	0.43	FALSE
46	The Cancer Genome Atlas	Breast Invasive Carcinoma	SUMF2	0.02	0.01	enet	6	0.01	5.1e-03	-3.22	6.3	2.3e-10	-0.39	0.05	0.17	FALSE
47	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHCHD2	0.07	0.04	enet	8	0.06	4.2e-04	8.25	6.8	1.1e-11	-0.30	0.09	0.05	FALSE
48	The Cancer Genome Atlas	Colon Adenocarcinoma	CHCHD2	0.09	0.07	lasso	4	0.06	1.5e-04	8.43	6.5	8.9e-11	-0.24	0.17	0.04	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHCHD2	0.11	0.05	blup	33	0.07	2.8e-08	8.52	6.6	4.0e-11	-0.25	0.98	0.02	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CHCHD2	0.05	0.04	blup	33	0.02	1.1e-03	8.25	5.4	7.4e-08	-0.16	0.94	0.01	FALSE
51	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GBAS	0.10	0.03	lasso	5	0.09	5.8e-10	-2.29	-5.7	1.1e-08	0.76	0.47	0.22	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHCHD2	0.03	0.01	blup	33	0.01	1.7e-02	1.84	5.3	1.0e-07	-0.18	0.01	0.04	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	GBAS	0.18	0.06	enet	12	0.13	6.0e-15	-3.12	-8.9	7.5e-19	0.82	0.92	0.08	FALSE
54	The Cancer Genome Atlas	Brain Lower Grade Glioma	PHKG1	0.04	0.02	blup	36	0.03	2.7e-04	8.25	9.1	8.2e-20	-0.37	0.14	0.03	FALSE
55	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUMF2	0.04	0.04	enet	5	0.04	1.4e-05	7.82	7.8	8.2e-15	-0.74	0.16	0.82	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF713	0.17	0.07	enet	14	0.09	1.1e-10	0.42	-5.4	5.3e-08	0.67	0.99	0.00	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	CHCHD2	0.03	0.02	lasso	2	0.02	1.2e-03	8.43	7.5	4.4e-14	-0.32	0.32	0.02	FALSE
58	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GBAS	0.07	0.00	enet	9	0.04	6.1e-05	-8.05	-7.0	2.5e-12	0.68	0.05	0.28	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CHCHD2	0.08	0.05	blup	33	0.04	1.5e-03	8.52	5.6	1.7e-08	-0.08	0.14	0.03	FALSE
60	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GBAS	0.07	0.03	blup	48	0.04	7.6e-04	0.42	-7.5	6.3e-14	0.80	0.02	0.09	FALSE
61	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GBAS	0.18	0.00	blup	48	0.11	2.6e-05	-3.12	-8.1	5.9e-16	0.87	0.03	0.27	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	GBAS	0.20	0.08	blup	48	0.21	8.4e-22	-8.04	-8.9	7.9e-19	0.82	0.19	0.81	FALSE
63	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSPH	0.07	0.01	blup	71	0.04	1.9e-05	-4.42	-8.2	2.1e-16	0.49	0.01	0.78	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHCHD2	0.08	0.02	blup	33	0.06	2.3e-05	0.96	5.5	3.8e-08	-0.17	0.21	0.02	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CHCHD2	0.13	0.04	blup	33	0.08	1.3e-03	-5.57	5.3	1.1e-07	-0.17	0.07	0.05	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	CHCHD2	0.08	0.03	enet	10	0.06	1.8e-06	8.52	6.4	1.8e-10	-0.29	0.32	0.11	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	GBAS	0.25	0.08	enet	22	0.26	5.5e-25	-2.40	-8.6	1.1e-17	0.83	0.80	0.20	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	PHKG1	0.07	0.06	enet	4	0.06	3.9e-06	-6.87	-8.8	9.8e-19	0.84	0.04	0.96	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	PSPH	0.06	0.01	lasso	8	0.01	4.8e-02	-4.42	-7.1	1.4e-12	0.48	0.02	0.62	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	ZNF713	0.16	0.10	enet	15	0.15	3.4e-14	7.78	5.1	2.9e-07	-0.17	0.04	0.96	FALSE