TWAS hub - PSPH

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1880	0.0510	1.9e-10	0.090	0.094	0.116	0.084	0.119	4.9e-11	1.5e-11	5.7e-14	1.9e-10	2.5e-14
2	GTEx	Esophagus Mucosa	0.1050	0.0430	1.4e-03	-0.004	NA	0.013	NA	0.001	6.9e-01	NA	4.4e-02	NA	2.5e-01
3	METSIM	Adipose	0.1641	0.0392	0.0e+00	0.132	0.151	0.164	0.151	0.174	3.3e-19	7.4e-22	7.9e-24	6.9e-22	2.9e-25
4	TCGA	Breast Invasive Carcinoma	0.0254	0.0135	5.0e-04	0.001	0.019	0.020	NA	0.013	1.6e-01	7.1e-05	3.8e-05	NA	8.9e-04
5	TCGA	Prostate Adenocarcinoma	0.0731	0.0359	2.9e-04	0.008	0.044	0.021	NA	0.022	4.2e-02	1.9e-05	2.4e-03	NA	2.3e-03
6	TCGA	Thyroid Carcinoma	0.0570	0.0280	1.9e-03	0.007	0.004	0.006	NA	0.008	6.5e-02	1.3e-01	7.8e-02	NA	4.8e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Major Depression (MDD)	6.2	7.5	14.6	3.1	0.1	3.4	1.2	3.8	2.8
Trunk fat-free mass	3.2	18.6	29.2	-5.4	-1.4	-5.3	-4.4	-4.0	-4.0
Trunk predicted mass	3.2	18.1	29.3	-5.4	-1.3	-5.3	-4.3	-4.0	-3.9
Whole body fat-free mass	3.0	16.9	28.2	-5.3	-1.4	-5.2	-4.1	-3.7	-3.7
Whole body water mass	2.9	16.5	27.4	-5.2	-1.4	-5.1	-4.1	-3.6	-3.7
Height	2.8	53.4	71.4	-6.9	-6.4	-6.6	-8.4	-8.2	-7.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	6.7	2.6	-1.6	1.4	1.9	1.3	1.3
Leg fat-free mass (left)	2.5	13.4	22.8	-4.8	-1.7	-4.8	-3.6	-3.2	-3.0
Standing height	2.5	24.7	34.1	-4.9	-4.5	-5.0	-5.8	-5.1	-4.3
Arm fat-free mass (right)	2.5	13.0	20.3	-4.5	-1.1	-4.5	-3.4	-3.3	-3.7
Arm predicted mass (right)	2.5	13.0	20.2	-4.5	-1.4	-4.4	-3.6	-3.2	-3.6
Basal metabolic rate	2.5	14.0	22.7	-4.8	-1.5	-4.7	-3.7	-3.4	-3.4
Schizophrenia (2014)	2.4	5.3	11.1	2.1	1.4	1.8	1.7	2.9	3.3
Leg predicted mass (left)	2.4	12.8	22.2	-4.7	-1.6	-4.7	-3.5	-3.1	-2.9
Arm predicted mass (left)	2.4	12.0	19.1	-4.4	-1.0	-4.2	-3.7	-2.9	-3.5
Average weekly fortified wine intake	2.3	2.8	5.5	2.4	0.1	2.3	-1.5	1.7	0.6
Hair/balding pattern: Pattern 2	2.3	2.9	5.5	1.1	1.8	0.9	2.3	1.3	2.2
Comparative height size at age 10	2.3	12.6	14.7	-3.4	-3.2	-3.6	-3.8	-3.8	-3.5
Sitting height	2.2	15.3	21.8	-4.2	-3.0	-4.7	-4.0	-3.9	-3.5
Medication: Ventolin 100micrograms inhaler	2.2	2.8	5.0	-1.8	-0.4	-2.2	-1.2	-2.1	-1.5
Medication: Seretide 50 evohaler	2.2	2.5	6.5	-1.3	-1.4	-1.6	-0.6	-1.5	-2.5
Leg fat-free mass (right)	2.2	11.7	20.8	-4.6	-1.5	-4.5	-3.4	-2.9	-2.7
Leg predicted mass (right)	2.2	11.7	20.5	-4.5	-1.5	-4.5	-3.4	-2.9	-2.7
Medication: Bendroflumethiazide	2.2	3.4	7.2	-1.3	-2.3	-0.9	-2.7	-0.8	-2.1
Alcohol drinker status: Previous	2.2	2.5	5.6	-0.8	-1.3	-0.3	-1.3	-2.2	-2.4
Alzheimer’s Disease (in father)	2.1	2.3	3.8	1.4	1.9	1.3	1.0	1.9	1.3
HbA1C	2.1	2.4	6.8	-1.1	-0.4	-1.5	-2.6	-1.8	0.5
Arm fat-free mass (left)	2.1	10.5	17.5	-4.2	-0.7	-4.1	-3.2	-2.7	-3.3
Financial difficulties in last 2 years	2.0	2.7	7.9	-1.5	-0.8	-1.4	1.0	-2.8	-1.6
Knee pain experienced in last month	2.0	3.1	9.5	-1.2	-1.4	-1.2	-1.7	-1.1	-3.1
Primary Biliary Cirrhosis	1.9	2.7	5.3	2.3	-0.7	2.3	-0.3	1.9	1.2
Chronic bronchitis/emphysema (father)	1.9	2.2	6.0	-2.3	1.3	-2.4	-0.5	0.1	0.3
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	9.2	3.0	0.2	3.0	0.8	1.5	2.1
Age at First Birth	1.8	2.7	9.6	0.2	3.1	0.0	2.0	0.1	1.5
Illnesses of father: Heart disease	1.8	2.5	5.1	1.9	0.7	2.2	1.0	1.8	1.1
Eye problems/disorders: Cataract	1.8	2.1	5.6	-0.5	0.3	-0.4	-2.4	-1.8	-1.9
Pain type(s) experienced in last month: Hip pain	1.8	2.3	6.6	-1.0	-1.2	-1.6	-1.3	-0.5	-2.6
Bipolar Disorder (2018)	1.7	2.7	5.2	2.2	-1.1	2.3	1.9	0.4	1.1
Bipolar Disorder or Schizophrenia	1.7	4.1	9.4	1.8	0.7	1.7	2.5	1.5	3.1
Had other major operations	1.7	2.1	3.4	1.7	0.3	1.4	0.8	1.9	1.8
Number of self-reported non-cancer illnesses	1.7	2.9	5.9	1.8	-2.4	1.4	-2.1	1.1	-1.0
Stomach or abdominal pain in last month	1.6	2.0	7.2	-1.4	2.7	-1.4	1.2	-0.2	0.0
Forced vital capacity (FVC)	1.6	6.0	8.2	-2.4	-2.5	-2.9	-2.2	-2.8	-1.7
Migraine (self-reported)	1.6	2.0	2.5	1.5	-1.6	1.2	-1.5	1.5	1.0
Mother’s age at death	1.6	2.0	3.5	1.5	1.9	1.0	1.6	1.4	0.8
Schizophrenia (2018)	1.5	3.2	9.2	0.7	2.0	0.5	1.7	1.6	3.0
Townsend deprivation index at recruitment	1.5	2.1	3.5	1.4	1.0	1.9	1.6	1.1	1.6
Falls in the last year	1.5	2.1	5.2	0.1	0.9	0.4	2.3	1.3	2.1
Hair/balding pattern: Pattern 3	1.5	2.2	5.1	-2.3	0.0	-0.8	-1.3	-1.9	-1.5
Lung cancer (father)	1.5	1.7	4.4	-1.0	0.1	-1.5	-0.3	-1.5	-2.1
Birth weight of first child	1.5	2.7	12.9	-0.1	-0.7	-0.0	-3.6	-1.3	-1.0
Shortness of breath walking on level ground	1.5	1.8	3.5	0.3	-1.3	-0.3	-1.9	-1.9	-1.5
Ulcerative Colitis	1.4	2.0	5.2	-2.1	0.6	-2.3	-0.3	-1.4	-0.4
Blood White Count	1.4	10.5	39.2	-1.2	6.3	-1.1	4.4	1.1	-1.1
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	3.0	-1.6	-0.3	-1.5	-0.4	-1.6	-1.7
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	3.8	-1.9	-1.4	-1.9	-1.9	-1.8	-1.2
Relative age of first facial hair	1.3	2.7	5.6	1.8	1.4	2.4	0.3	1.9	1.4
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	8.4	2.5	-0.3	2.9	0.4	0.8	1.6
Medication: Simvastatin	1.3	1.9	7.9	-0.1	-1.3	0.2	-2.8	0.2	-1.2
Father’s age at death	1.3	1.7	3.6	-1.9	0.8	-1.2	-1.6	-0.5	-1.3
Worrier / anxious feelings	1.3	2.4	12.0	-0.1	-3.5	-0.0	0.2	-1.5	0.2
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.2	5.4	-1.8	1.0	-2.3	-0.7	-1.5	-0.7
Illnesses of mother	1.3	1.6	4.1	-1.6	0.6	-2.0	-0.3	-1.5	0.3
Chronic bronchitis/emphysema (mother)	1.3	1.5	4.2	-1.8	-0.9	-2.0	-0.3	-0.7	0.2
Systolic Blood Pressure	1.2	5.9	17.1	1.4	2.3	1.0	4.1	3.0	1.3
Diabetes (father)	1.2	1.5	5.9	-0.2	0.5	-0.2	1.1	1.3	2.4
High blood pressure (mother)	1.2	1.7	4.3	0.8	-2.1	1.3	-1.9	0.2	-0.5
Hip circumference	1.2	5.3	10.4	-2.2	-0.9	-2.8	-2.0	-1.9	-3.2
Medication: Paracetamol	1.2	2.0	3.9	1.6	1.3	0.9	1.4	2.0	1.0
Forced vital capacity (FVC), Best measure	1.2	4.5	7.0	-2.6	-1.5	-2.6	-2.0	-2.4	-1.2
Medication for pain relief, constipation, heartburn	1.2	2.0	5.9	-1.8	0.0	-1.0	0.7	-2.4	-1.1
Heart disease (mother)	1.2	1.5	4.2	0.2	1.6	0.7	2.0	1.2	-0.0
Back pain experienced in last month	1.2	1.7	4.3	-1.2	-2.1	-1.8	0.4	-0.9	-0.6
Breast cancer (self-reported)	1.2	1.5	3.8	-0.5	-1.8	-0.5	0.2	-2.0	-1.2
Financial situation satisfaction	1.2	1.5	4.7	-1.3	-0.9	-0.8	2.2	-0.9	0.1
Schizophrenia vs Biploar Disorder	1.1	1.5	6.7	-0.4	1.0	-0.1	-2.6	-0.7	-0.7
Crohns Disease (2017)	1.1	2.4	7.5	-1.8	2.7	-1.2	1.4	-0.6	-0.3
Rheumatoid Arthritis	1.1	1.5	6.5	-0.4	2.6	0.1	1.3	0.9	-0.0
Age when periods started (menarche)	1.1	2.6	5.4	1.9	0.0	1.9	2.3	1.3	1.1
Medication: Levothyroxine sodium	1.1	1.8	5.3	1.9	-1.2	2.3	-0.7	0.4	-0.4
Impedance of leg (left)	1.1	5.6	13.1	3.6	-0.2	3.3	2.2	1.7	1.3
Weight	1.1	5.5	7.3	-2.7	-1.2	-2.7	-2.5	-2.0	-2.6
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	5.9	-1.2	-2.4	-1.8	-2.3	-2.3	-0.7
Exposure to tobacco smoke at home	1.1	1.2	4.0	1.0	0.7	0.7	0.7	0.8	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	3.0	1.2	-0.8	0.7	-1.7	-0.4	-1.3
Osteoarthritis (self-reported)	1.1	1.4	2.7	-1.6	-0.2	-1.4	-1.6	-0.7	-1.0
Fractured/broken bones in last 5 years	1.1	1.4	3.1	-1.0	-1.8	-0.0	-1.6	-1.2	-0.7
Heart disease (siblings)	1.1	1.4	2.4	1.2	0.5	1.2	1.4	0.8	1.6
Impedance of whole body	1.1	5.5	13.7	3.7	-1.5	3.1	1.7	1.3	1.6
Irritable Bowel Disease (IBD)	1.0	2.3	5.8	-2.2	2.4	-1.4	0.7	-0.8	-0.1
Coronary Artery Disease (CAD)	1.0	1.2	3.8	-0.9	1.9	-0.7	0.9	0.6	0.7
Crohns Disease (2012)	1.0	1.6	6.6	-1.2	2.6	-0.7	1.1	-0.2	-0.1
Chronotype (morning person)	1.0	2.4	6.2	-0.8	2.5	-0.9	0.2	1.9	1.8
Pack years adult smoking proportion	1.0	1.6	3.8	-0.9	1.8	-1.1	1.9	0.8	0.0
Time employed in main current job	1.0	1.2	2.0	-1.3	-1.0	-1.4	0.7	-0.7	-1.2
Prospective memory result	1.0	1.2	6.1	0.9	-2.5	0.4	-0.3	-0.3	0.0
Peak expiratory flow (PEF)	1.0	2.3	5.3	-0.8	-1.9	-1.3	-2.3	-1.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.0	-1.3	-1.3	-1.0	-1.1	-1.4	0.0
Number of children fathered	1.0	1.1	1.8	-1.3	0.1	-1.1	-0.9	-1.4	-1.0
Medication: Omeprazole	1.0	1.1	2.6	-1.1	-0.7	-0.8	-1.6	-1.1	-0.9
Commuting to job workplace: Walk	1.0	1.1	1.9	0.9	-1.4	1.3	0.2	1.4	0.6
Medication: Gliclazide	1.0	1.1	3.0	-0.2	0.7	0.8	1.0	1.2	1.7
Hearing aid user	1.0	1.2	5.8	-0.7	2.4	-0.4	-0.5	0.5	0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.3	5.8	0.5	-2.4	0.6	-1.0	0.4	0.1
Irritability	1.0	1.6	3.6	-1.8	-0.8	-1.9	-0.0	-1.4	-0.6
Risk taking	1.0	1.5	3.3	0.9	1.8	0.7	1.8	0.9	0.5
Ever depressed for a whole week	1.0	1.3	2.1	-0.7	-1.3	-0.8	-1.1	-1.3	-1.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.7	-1.2	0.8	-1.1	0.4	-1.6	-1.3
Blood Red Count	0.9	8.5	14.7	3.4	-3.4	3.4	-3.8	0.1	1.3
Heart attack	0.9	1.1	2.3	-1.1	0.8	-1.1	0.2	-1.5	-1.0
Medication: Lansoprazole	0.9	1.0	3.3	0.7	1.8	0.4	-0.3	1.4	0.1
Loud music exposure frequency	0.9	1.0	2.5	-1.3	-1.1	-0.4	1.6	-0.6	-0.2
Blood clot in the leg (DVT)	0.9	1.1	5.5	-0.6	-2.3	-0.9	-0.4	-0.2	-0.4
Number of full brothers	0.9	1.1	5.0	0.5	2.2	0.7	0.2	-0.0	0.8
Suffer from ‘nerves’	0.9	1.4	2.8	1.1	-1.5	1.7	-1.5	-0.1	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	3.0	-1.7	0.8	-1.4	0.5	-0.1	-0.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.1	-0.3	-1.2	-0.3	-1.1	-1.2	-1.4
Medication: Lisinopril	0.9	1.1	3.9	-0.8	-1.1	-0.3	-0.9	-0.5	-2.0
Average weekly beer plus cider intake	0.9	1.4	3.8	-1.5	-0.5	-1.9	1.0	-0.9	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	5.3	-0.6	-2.3	-0.9	-0.6	-0.1	-0.1
Supplements: Zinc	0.8	0.8	2.7	0.8	0.1	1.6	-0.5	0.3	-1.1
Impedance of leg (right)	0.8	3.7	9.0	3.0	-0.9	2.8	1.7	1.0	0.7
Current tobacco smoking	0.8	1.3	2.4	-1.1	0.5	-0.9	0.9	-1.4	-1.6
Medication: Atenolol	0.8	1.0	2.1	1.2	-0.0	1.5	-1.3	0.9	0.3
Number of incorrect matches in round	0.8	1.3	4.8	0.8	0.1	1.2	-0.1	-0.8	-2.2
Alcohol usually taken with meals	0.8	1.2	6.8	0.6	-0.4	0.2	-2.6	0.0	0.3
Had menopause	0.8	1.0	4.5	-0.2	-0.2	-0.4	-1.0	-0.6	-2.1
Happiness	0.8	1.0	3.6	-0.5	1.4	0.2	1.9	0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.7	4.1	-1.6	-1.7	-1.7	-2.0	-1.8	-0.3
Impedance of arm (left)	0.8	3.9	8.8	3.0	-2.1	2.4	1.2	0.7	1.6
Headache pain in last month	0.8	1.4	3.0	1.4	-1.7	0.5	-1.2	-0.2	-1.2
Overall health rating	0.8	1.8	4.5	-1.7	0.3	-2.1	-0.3	-0.8	-1.6
Age at last live birth	0.8	1.2	4.4	-0.7	2.1	-0.4	-0.4	-1.3	-0.4
Qualifications: nursing, teaching	0.8	1.2	3.1	-0.9	1.1	-1.8	-0.9	0.6	1.1
Illnesses of father: None of the above (group 1)	0.8	0.9	2.3	0.3	-1.0	-0.2	-0.7	-1.2	-1.5
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.0	-0.6	-1.2	-1.4	-1.1	-0.3	-0.4
Pack years of smoking	0.8	1.1	2.8	-0.7	1.4	-1.0	1.7	0.6	-0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.8	1.3	0.9	1.2	0.4	1.2	0.7
Breast Cancer	0.7	1.6	5.0	2.2	-0.6	1.9	0.5	0.5	-0.2
Prostate Cancer	0.7	1.0	2.3	0.9	-1.5	1.0	-1.4	0.1	-0.4
Heel T-Score	0.7	5.8	11.6	3.4	-0.8	3.3	-0.1	2.6	2.1
Sensitivity / hurt feelings	0.7	1.1	2.9	-1.1	-1.7	-0.5	-0.5	-1.4	0.2
Systolic blood pressure, automated reading	0.7	2.1	5.4	1.3	0.9	0.9	2.0	2.3	0.5
Medication for hormone replacement therapy	0.7	0.8	2.3	1.5	0.6	0.8	1.0	0.6	-0.1
Hand grip strength (right)	0.7	2.0	3.9	-1.7	-0.2	-1.9	-1.0	-2.0	-0.7
Taking other prescription medications	0.7	1.0	3.5	0.3	-0.2	-0.1	-1.9	-0.2	-1.6
Supplements: Glucosamine	0.7	0.9	3.3	-0.6	-1.1	-0.4	-1.8	-0.7	0.1
Noisy workplace	0.7	0.9	1.6	-1.2	1.1	-0.8	1.3	0.7	0.1
Medication: Cholesterol lowering	0.7	1.1	1.7	-1.0	-1.0	-0.5	-1.1	-0.9	-1.3
Age at first live birth	0.7	1.3	7.5	-0.1	2.7	-0.1	0.2	-0.1	0.5
Medication: Blood pressure	0.7	1.3	4.1	-0.9	-0.6	-0.6	-2.0	-0.8	-1.1
Pulse rate, automated reading	0.7	2.3	8.2	-0.2	2.2	0.4	2.9	0.5	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	3.1	-0.4	0.8	-0.4	-1.8	-0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	3.0	-1.5	0.9	-1.7	-0.6	0.4	0.5
Mineral and other dietary supplements	0.7	1.0	2.2	-1.0	1.5	-1.2	1.0	-0.3	0.0
Medication: Aspirin	0.7	0.9	1.7	1.2	0.9	0.5	-0.8	1.3	0.5
Smoking status: Current	0.7	1.2	2.2	-1.3	0.3	-0.9	0.8	-1.5	-1.2
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	-1.4	0.8	-0.7	-0.0	-1.1	-0.6
High cholesterol (Self-reported)	0.7	1.3	3.0	0.0	-1.2	0.5	-1.7	-0.0	-1.7
Medication: Paracetamol	0.7	1.1	2.5	1.6	0.5	1.1	1.0	1.1	0.7
Illnesses of father: High blood pressure	0.7	0.9	2.0	-1.0	1.2	-1.4	0.3	0.1	0.9
Commuting to job workplace: Cycle	0.7	0.8	1.9	1.0	1.1	1.4	-0.4	-0.0	-0.8
Cholesterol lowering medication	0.7	1.0	1.7	1.1	-1.1	1.0	-1.3	0.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	-1.0	-0.7	-0.8	-1.3	-1.0	-0.8
Depression (Nagel 2018)	0.6	0.9	2.0	-1.2	1.4	-1.1	-0.7	-0.1	0.5
HDL Cholesterol	0.6	1.1	1.8	-1.0	-0.7	-1.1	-1.0	-0.9	-1.3
Waist Hip Ratio (WHR)	0.6	2.7	4.4	1.7	-0.2	1.7	1.5	2.1	1.9
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.8	1.3	0.2	0.9	1.1	1.3	1.0
Lung FEV1/FVC ratio	0.6	3.0	6.2	2.3	-1.8	2.5	-1.7	0.3	0.3
Number of treatments/medications taken	0.6	1.1	2.0	1.0	-1.1	0.7	-1.4	0.8	-1.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.6	1.3	0.2	1.0	0.9	0.7	-0.5
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.7	-1.3	-0.3	-1.0	-0.4	-0.5	-0.9
Impedance of arm (right)	0.6	2.8	5.9	2.4	-2.0	2.1	0.8	0.5	1.4
Breastfed as a baby	0.6	0.7	2.8	-0.2	-0.5	-0.4	-0.5	-1.7	-0.8
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.0	0.3	-0.3	-0.1	-1.7	1.4	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.4	1.5	-0.2	0.7	-0.0	0.7	-0.7
Qualifications: College or University degree	0.6	1.8	5.9	1.4	2.4	1.1	0.2	0.4	1.3
Leg pain on walking	0.6	0.7	1.9	-1.4	0.3	-0.9	-0.2	-0.5	-1.1
Ever taken oral contraceptive pill	0.6	0.7	2.0	1.1	0.5	0.4	1.4	-0.3	0.6
Alcohol drinker status: Never	0.6	0.7	2.2	0.1	-0.9	0.6	1.5	0.7	0.8
Pain experienced in last month	0.6	1.1	3.8	-0.3	1.4	0.4	0.3	0.6	1.9
Worry (Nagel 2018)	0.5	1.1	3.7	-0.1	-1.9	0.4	-0.6	-1.6	0.2
Ovarian Cancer	0.5	0.6	2.0	-0.7	1.0	-0.1	1.4	-0.4	0.4
Fasting Glucose	0.5	0.5	1.6	-1.3	0.2	-1.2	0.2	0.1	0.4
Blood Eosinophil Count	0.5	3.6	8.1	-1.8	0.5	-2.0	-1.7	-1.7	-2.8
Cardiovascular Disease	0.5	1.6	3.2	1.8	-1.0	1.6	-0.4	1.5	0.7
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.6	-0.9	1.6	-1.0	0.4	-0.1	0.1
Angina	0.5	0.7	1.9	-0.7	0.2	-1.4	-1.0	-0.3	0.7
Medication: Metformin	0.5	0.7	1.5	-0.5	0.2	-0.4	1.2	0.9	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.5	-0.8	1.2	-1.1	0.2	-0.2	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.5	0.1	1.2	0.7	0.6	0.9	-0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.2	-0.5	0.4	-0.4	1.5	0.5	0.6
Multivitamins +/- minerals	0.5	0.6	2.1	0.7	-0.6	0.8	0.0	-0.1	-1.4
Pain all over the body in last month	0.5	0.6	2.2	-0.1	-0.8	0.1	-1.5	-0.6	0.1
Fluid intelligence score	0.5	1.0	2.5	0.4	1.6	0.2	-0.4	1.1	1.5
Number of live births	0.5	0.7	1.7	0.6	-0.0	1.2	0.3	-0.7	-1.3
Mouth/teeth dental problems: Dentures	0.5	0.8	1.8	0.8	-0.9	0.5	-1.3	-0.4	-1.1
Asthma	0.5	1.0	3.9	-0.1	1.0	-2.0	0.9	-0.1	-0.4
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	0.5	0.9	0.1	1.4	0.4	1.2
Glaucoma (self-reported)	0.5	0.5	1.1	-0.4	-0.5	-1.0	-0.2	-0.8	-1.0
Birth weight	0.5	1.0	1.9	-1.0	-0.4	-1.4	-1.2	-1.2	-0.1
High blood pressure (siblings)	0.5	0.7	1.8	0.4	0.4	0.1	-0.8	1.3	1.3
Emphysema/chronic bronchitis	0.5	0.6	1.1	-1.0	0.1	-1.0	0.6	0.3	1.0
Number of full sisters	0.5	0.6	2.3	-0.2	0.5	-0.4	-0.2	-1.5	-1.0
Chest pain or discomfort	0.5	0.8	2.5	-0.7	0.4	-1.0	-1.6	0.1	0.6
Had major operations	0.5	0.6	1.9	-0.6	0.3	-1.1	-0.1	-1.4	-0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.3	-0.6	1.1	-1.1	0.8	0.2	0.2
Medication: Aspirin	0.5	0.7	1.5	0.9	0.9	0.2	-0.9	1.2	0.4
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.4	-0.7	-1.2	0.8	-0.1	0.1	1.2
Friendships satisfaction	0.5	0.6	1.4	-0.9	0.6	-0.8	0.4	-1.2	0.2
Asthma (self-reported)	0.5	0.9	3.5	-0.3	1.2	-1.9	0.8	-0.0	-0.2
Guilty feelings	0.5	0.7	3.5	0.2	-0.1	0.1	-0.4	0.7	1.9
Wears glasses or contact lenses	0.5	0.5	2.1	0.7	-0.7	-0.1	-1.4	0.2	0.2
Commuting to job workplace: Public transport	0.5	0.6	1.5	-0.1	-0.9	-0.3	-1.2	-0.8	-0.8
Unable to work because of sickness or disability	0.5	0.7	1.3	-1.1	-1.1	-0.5	0.1	-0.7	-1.0
Myopia	0.5	0.7	1.2	1.1	-0.9	1.0	-0.7	-0.1	0.8
Ulcerative Colitis (UC)	0.4	0.7	1.7	-1.3	1.3	-0.6	-0.1	-0.5	0.5
Triglycerides	0.4	0.7	1.4	0.2	1.2	0.1	1.1	0.7	1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	2.3	0.5	1.5	0.6	0.0	0.0	0.0
Blood Platelet Count	0.4	4.7	11.4	1.1	3.4	1.2	2.3	2.9	0.7
Hand grip strength (left)	0.4	1.2	3.5	-1.9	0.5	-1.5	0.1	-1.0	0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.3	-0.3	0.8	0.5	-1.1	-0.2	-0.5
Medication: Co-codamol	0.4	0.5	1.1	0.4	-0.0	0.5	1.0	1.1	0.6
Diabetes (mother)	0.4	0.5	1.1	1.0	1.0	0.4	1.0	0.2	0.1
High blood pressure	0.4	1.2	2.2	0.5	-0.9	0.4	-1.5	1.2	-1.5
Past tobacco smoking	0.4	0.7	1.6	-1.2	-0.7	-1.3	-0.1	-0.7	-0.5
Nervous feelings	0.4	0.8	3.9	-0.2	-2.0	0.2	-0.0	-0.8	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	1.2	-0.9	0.5	0.0	0.8	0.1
Depression (self-reported)	0.4	0.5	1.1	0.9	0.2	0.9	-0.6	1.0	0.3
Pulse wave reflection index	0.4	0.6	1.8	1.4	-0.2	0.9	0.5	-0.0	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.2	-0.3	-0.5	-0.4	1.0	0.2	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.0	0.5	-0.9	0.9	-1.4	-0.1	-0.7
Medication: Amlodipine	0.4	0.5	1.1	0.4	-1.0	0.9	-0.3	-0.1	-1.0
Comparative body size at age 10	0.4	1.2	3.1	1.0	-1.8	1.1	0.7	0.7	1.0
Wheeze or whistling in the chest in last year	0.4	0.6	1.9	-1.0	0.3	-1.4	0.4	-0.8	-0.0
Pulse wave peak to peak time	0.4	0.5	1.5	-1.2	0.1	-0.8	-0.5	-0.5	-0.1
Health satisfaction	0.4	0.6	0.9	0.5	-0.6	0.9	-1.0	-0.6	-0.8
Eye problems/disorders: None of the above	0.4	0.5	2.1	0.1	-0.3	-0.2	1.4	0.7	0.5
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.5	0.2	-0.9	-0.4	-0.6	0.3	-1.2
Neck or shoulder pain in last month	0.4	0.6	1.2	-0.7	-0.0	-1.1	0.7	-0.4	-1.1
Medication: Ibuprofen	0.4	0.5	1.0	0.9	0.0	0.5	0.6	1.0	0.5
Illnesses of siblings: Diabetes	0.4	0.5	1.5	0.1	-1.2	-0.2	-0.1	-0.9	0.8
Loneliness, isolation	0.4	0.5	2.0	0.3	0.7	0.7	1.4	-0.3	-0.2
Medication for cholesterol	0.4	0.7	1.9	-1.4	0.6	-0.9	0.5	-0.9	0.2
Average weekly champagne plus white wine intake	0.4	0.6	1.4	-0.1	1.2	0.5	-0.4	0.6	1.1
Medication: Atorvastatin	0.4	0.5	1.8	0.3	-1.3	0.5	-0.3	-1.0	-0.3
Leg fat percentage (left)	0.4	1.3	1.9	1.3	1.4	1.2	1.1	1.4	-0.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.7	-0.6	0.7	-0.3	1.2	-0.9	1.6
Neuroticism (Nagel 2018)	0.3	0.8	2.2	-0.8	-1.1	-0.3	-1.5	-0.7	0.5
Mean Putamen Volume	0.3	0.4	1.2	-0.4	1.1	-0.4	0.6	0.3	0.3
LDL Cholesterol	0.3	0.5	2.2	0.0	1.5	-0.0	0.6	0.5	0.3
Lupus	0.3	0.5	1.4	-0.3	1.1	-0.2	-0.2	-1.2	0.6
Neuroticism (2016)	0.3	0.4	1.3	0.4	0.9	1.1	-0.1	0.6	0.2
Smoking Status	0.3	0.6	2.4	-0.2	1.1	0.0	1.5	-0.2	-0.1
Respiratory disease	0.3	0.7	2.1	0.3	1.4	-0.9	0.9	0.5	0.1
Lung FVC	0.3	1.4	3.9	-1.4	0.3	-2.0	-0.8	-0.8	-1.0
Vitamin and mineral supplements	0.3	0.4	1.1	-1.0	0.6	-0.5	-0.1	0.0	1.0
Maternal smoking around birth	0.3	0.5	1.3	0.3	0.3	0.0	0.9	0.6	1.1
Fed-up feelings	0.3	0.5	1.2	-0.9	0.3	-0.7	-1.1	-0.5	0.2
Relative age voice broke	0.3	0.4	0.9	-0.6	0.6	0.0	0.9	-0.9	0.5
Qualifications: CSEs or equivalent	0.3	0.4	0.9	0.5	-0.9	0.6	0.9	-0.3	-0.1
Waist circumference	0.3	1.1	2.8	-0.9	-0.1	-1.1	-1.2	-0.2	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.7	-0.6	-0.5	-0.5	0.1	-0.2	1.3
Qualifications: None of the above	0.3	0.7	3.0	-0.4	1.0	-0.5	1.7	0.2	-0.0
Mouth/teeth dental problems	0.3	0.4	1.0	0.3	0.1	0.7	1.0	0.1	1.0
Medication: Ramipril	0.3	0.4	0.8	-0.6	-0.5	-0.8	-0.9	0.1	-0.7
Illnesses of siblings	0.3	0.4	1.1	-1.0	0.4	-0.7	0.1	-0.5	-0.4
Pulse rate	0.3	0.5	1.5	-0.2	-0.1	1.2	1.1	0.1	-0.3
Hair/balding pattern: Pattern 4	0.3	0.7	2.2	-0.8	0.5	-0.6	-0.9	-0.3	-1.5
Gout (self-reported)	0.3	0.5	1.4	1.0	-0.3	1.2	0.1	0.6	-0.0
Exposure to tobacco smoke outside home	0.3	0.4	1.6	-0.4	-0.2	-0.5	1.3	-0.2	0.3
Worry too long after embarrassment	0.3	0.5	1.4	-0.9	-0.3	-0.5	-0.5	-1.2	-0.5
Angina (self-reported)	0.3	0.4	0.9	-0.3	0.4	-0.9	-0.8	0.2	0.9
Medication: Allopurinol	0.3	0.5	1.3	1.1	0.0	1.0	-0.5	0.3	-0.0
Family relationship satisfaction	0.3	0.3	1.1	-0.5	1.0	-0.0	0.3	-0.7	0.0
Supplements: Vitamin C	0.3	0.3	0.8	0.6	-0.1	-0.5	0.6	0.9	0.2
Hypertension (Self-reported)	0.3	0.9	2.0	0.5	-1.1	0.4	-1.0	1.4	-0.8
Smoking status: Previous	0.3	0.4	1.0	0.8	1.0	0.5	0.2	0.8	0.4
Long-standing illness, disability or infirmity	0.3	0.4	1.7	-0.6	-0.1	-1.3	-0.6	-0.0	-0.3
Diabetes diagnosed by doctor	0.3	0.4	1.0	0.2	-0.4	0.1	0.8	0.8	1.0
Medication: Blood pressure	0.3	0.6	1.5	0.1	-1.2	0.1	-0.5	0.4	-1.2
Supplements: Calcium	0.3	0.4	1.5	-0.1	-0.8	-0.1	-0.0	0.1	-1.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.2	-0.3	0.3	-0.3	-1.1	0.0	0.8
Intelligence (Savage-Jansen 2018)	0.2	0.5	2.0	-0.5	0.7	-0.0	-1.4	-0.4	0.2
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.8	-0.2	0.9	0.4	0.2	-0.2
Reaction Time	0.2	0.4	1.4	0.1	1.2	0.3	0.5	0.7	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.2	-0.5	1.0	-0.0	-1.1	-0.0	0.3
Body Mass Index (BMI) (2010)	0.2	0.3	1.0	0.7	0.3	1.0	0.1	0.1	-0.1
Neuroticism	0.2	0.6	2.5	-0.0	0.2	0.2	0.8	0.6	1.6
Hearing difficulty/problems: Yes	0.2	0.2	0.7	-0.0	-0.4	0.3	0.5	0.8	0.5
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	0.3	0.0	0.5	0.6	0.7	0.8
Severe depression (siblings)	0.2	0.3	0.5	0.6	0.4	0.7	-0.7	0.2	-0.2
Trunk fat percentage	0.2	0.8	1.9	1.4	-1.1	0.8	0.1	0.9	-0.5
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.3	0.0	0.2	0.2	-1.1	-0.6	-0.7
Trunk fat mass	0.2	0.9	2.1	-0.1	-1.1	-0.6	-1.2	-0.3	-1.5
Diabetes (self-reported)	0.2	0.3	0.6	0.6	-0.8	0.4	0.4	0.6	0.3
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.8	-0.8	0.4	-0.2	-0.9	-0.5	0.2
Alcohol intake versus 10 years previously	0.2	0.3	0.7	0.6	-0.5	-0.1	-0.7	-0.8	-0.1
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.0	-0.0	0.4	-0.4	-1.0	0.9	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	1.0	0.5	-1.0	0.2	-0.1	0.1	-0.0
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	0.8	-0.5	0.4	0.0	0.1	-0.2
Arm fat mass (right)	0.2	0.7	1.7	-0.7	-0.6	-0.8	-0.8	-0.6	-1.3
Leg fat percentage (right)	0.2	0.8	1.3	1.1	0.9	1.1	0.8	1.0	-0.5
Whole body fat mass	0.2	0.6	1.7	-0.3	-0.9	-0.5	-1.0	-0.2	-1.3
Leg fat mass (right)	0.2	0.6	2.2	-0.6	-0.0	-0.7	-0.8	-0.4	-1.5
Average weekly red wine intake	0.2	0.4	1.0	0.4	0.5	0.1	0.8	0.2	1.0
Ever had bowel cancer screening	0.2	0.3	0.6	0.5	-0.8	0.2	-0.5	0.5	0.2
Osteoporosis (self-reported)	0.2	0.2	0.7	0.4	-0.5	0.2	-0.6	0.1	0.8
Ever smoked	0.2	0.4	1.0	1.0	0.2	0.8	0.4	0.5	0.4
Diastolic blood pressure, automated reading	0.2	0.5	1.6	0.5	0.8	0.0	0.8	1.3	-0.1
BMI	0.1	0.8	2.3	0.9	0.7	0.8	-0.6	1.5	0.6
Allergy or Eczema	0.1	0.2	0.4	0.0	0.5	0.6	-0.2	-0.6	-0.4
Hypothyroidism (self reported)	0.1	0.3	0.8	0.4	-0.4	0.5	-0.9	0.0	-0.7
Hair Pigment	0.1	2.9	6.6	2.5	0.2	2.6	1.4	1.4	0.8
Average weekly spirits intake	0.1	0.2	0.5	0.1	0.3	-0.3	-0.1	0.7	0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.2	-0.5	0.0	0.1	-0.0	-0.6
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	-0.1	0.6	0.1	-0.6	0.3	-0.2
Serious illness, injury or assault to yourself	0.1	0.1	0.4	-0.3	-0.1	-0.2	-0.5	-0.1	0.7
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.5	-0.4	-0.3	-0.4	-0.4	-0.7
Allergy	0.1	0.2	0.8	0.1	-0.4	0.9	0.4	0.3	0.1
Neuroticism score	0.1	0.2	0.5	-0.1	-0.7	-0.1	-0.3	-0.5	0.7
Arm fat percentage (right)	0.1	0.4	1.1	1.1	-0.1	0.8	0.6	0.7	-0.2
Length of working week for main job	0.1	0.1	0.4	0.2	0.0	0.6	-0.5	-0.1	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.5	-0.4	0.2	-0.3	-0.4	0.0
Body fat percentage	0.1	0.6	1.4	1.2	-0.4	0.8	0.3	0.9	-0.6
Mean time to correctly identify matches	0.1	0.2	0.7	-0.2	0.4	0.4	-0.1	-0.2	-0.8
Alcohol intake frequency.	0.1	0.2	0.4	-0.0	-0.5	0.7	-0.4	-0.5	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	0.1	0.4	0.3	-0.2	0.4	-0.5
Arm fat percentage (left)	0.1	0.4	1.0	1.0	-0.1	0.7	0.8	0.6	-0.2
Mood swings	0.1	0.2	0.6	0.0	0.7	-0.1	-0.7	-0.1	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.4	0.6	-0.0	0.2	0.1	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.3	-0.6	0.6	-0.5	0.4	0.2
Arm fat mass (left)	0.1	0.4	1.2	-0.5	-0.4	-0.8	-0.4	-0.3	-1.1
Miserableness	0.1	0.2	0.4	-0.7	0.5	-0.6	-0.5	-0.2	0.3
Number of operations (self-reported)	0.1	0.2	0.9	0.3	0.1	-0.2	-0.9	0.3	0.1
Age started oral contraceptive pill	0.1	0.2	0.3	0.1	0.6	-0.4	-0.4	0.5	0.1
Basal cell carcinoma (self-reported)	0.1	0.2	0.5	-0.2	0.3	-0.5	-0.3	-0.2	-0.7
Leg fat mass (left)	0.1	0.6	2.0	-0.6	0.3	-0.7	-0.6	-0.2	-1.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.6	1.7	-0.6	-1.3	-0.7	0.1	-0.5	-0.9
Body mass index (BMI)	0.0	0.2	0.6	-0.3	0.6	-0.3	0.1	0.3	-0.8
Tense / ‘highly strung’	0.0	0.1	0.1	0.2	0.2	0.2	0.3	-0.3	0.3

Hub : Genes

PSPH

Models

Trait associations