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chr7:42,244,373-46,658,015

Best TWAS P=1.33e-19 · Best GWAS P=1.47e-51 conditioned to 1.18e-32

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DBNL	0.21	0.10	lasso	4	0.14	1.1e-16	-4.8	-6.0	1.9e-09	-0.02	0.72	0.28	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TBRG4	0.23	0.21	enet	27	0.22	5.6e-27	4.7	5.3	1.2e-07	-0.04	0.77	0.23	FALSE
3	GTEx	Adipose Visceral Omentum	URGCP	0.13	0.00	enet	9	0.00	2.2e-01	-3.6	-5.2	1.6e-07	0.00	0.12	0.04	FALSE
4	GTEx	Artery Aorta	H2AFV	0.10	0.08	lasso	2	0.06	1.9e-04	-5.2	-5.2	2.2e-07	-0.02	0.15	0.66	FALSE
5	GTEx	Breast Mammary Tissue (Male)	NUDCD3	0.37	0.01	lasso	7	0.02	9.2e-02	3.3	5.1	2.9e-07	0.01	0.08	0.06	TRUE
6	GTEx	Cells Transformed fibroblasts	AC017116.11	0.24	0.22	lasso	6	0.23	3.0e-17	-4.8	5.5	4.3e-08	0.01	0.60	0.40	FALSE
7	GTEx	Esophagus Mucosa	TBRG4	0.12	0.07	lasso	9	0.08	3.6e-06	4.7	5.2	2.6e-07	-0.01	0.18	0.80	FALSE
8	GTEx	Heart Atrial Appendage	SEPT7P2	0.15	0.00	lasso	9	0.08	1.8e-04	-7.7	-7.2	6.7e-13	-0.05	0.20	0.06	TRUE
9	GTEx	Skin Sun Exposed Lower leg	IGFBP3	0.09	0.00	lasso	6	0.00	2.7e-01	-8.5	-9.1	1.3e-19	-0.27	0.15	0.03	TRUE
10	GTEx	Thyroid	H2AFV	0.15	0.04	lasso	6	0.08	1.8e-06	-5.2	-6.3	2.5e-10	-0.02	0.05	0.88	FALSE
11	GTEx	Thyroid	TBRG4	0.15	0.06	enet	14	0.08	9.1e-07	4.4	5.5	4.4e-08	0.01	0.22	0.78	TRUE
12	NTR	Blood	IGFBP3	0.03	0.00	bslmm	413	0.01	1.1e-05	2.3	7.6	3.9e-14	0.10	0.16	0.03	TRUE
13	NTR	Blood	ZMIZ2	0.08	0.06	enet	17	0.06	1.5e-18	-5.6	5.8	8.0e-09	0.01	0.00	1.00	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	AEBP1	0.34	0.20	lasso	11	0.21	7.8e-27	-4.8	-5.4	5.2e-08	0.04	0.61	0.39	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	ZMIZ2	0.10	0.06	enet	15	0.07	1.3e-09	-5.8	-6.6	5.4e-11	-0.01	0.02	0.98	TRUE
16	ROSMAP	Brain Pre-frontal Cortex	DBNL	0.41	0.23	lasso	4	0.32	1.5e-41	4.6	-5.7	1.2e-08	-0.03	0.85	0.15	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	RP11-111K18.2	0.10	0.04	bslmm	443	0.06	4.8e-08	4.5	-5.8	6.7e-09	-0.01	0.59	0.37	TRUE
18	YFS	Blood	DBNL	0.19	0.08	lasso	13	0.15	4.4e-46	4.1	-5.6	2.0e-08	-0.03	0.97	0.02	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PGAM2	0.09	0.05	lasso	2	0.04	1.5e-04	-4.8	5.7	1.3e-08	-0.01	0.00	0.78	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	DBNL	0.17	0.06	lasso	3	0.06	2.0e-11	4.6	-5.5	2.8e-08	-0.03	0.01	0.96	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	DBNL	0.39	0.12	lasso	2	0.15	3.2e-16	4.6	-5.7	1.1e-08	-0.03	0.01	0.96	FALSE
22	The Cancer Genome Atlas	Soft Tissue Sarcoma	DBNL	0.14	0.00	enet	8	0.04	3.4e-03	-4.6	-5.3	1.4e-07	-0.05	0.00	0.14	FALSE
23	The Cancer Genome Atlas	Soft Tissue Sarcoma	ZMIZ2	0.05	0.02	blup	33	0.02	1.7e-02	4.1	-5.5	3.0e-08	-0.02	0.02	0.17	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	DBNL	0.19	0.03	lasso	3	0.08	6.0e-08	-4.8	-6.0	1.7e-09	-0.02	0.00	0.95	TRUE
25	The Cancer Genome Atlas	Thyroid Carcinoma	TBRG4	0.09	0.09	blup	61	0.09	3.2e-09	4.7	5.2	2.2e-07	-0.01	0.12	0.88	FALSE