Best TWAS P=3.99e-09 · Best GWAS P=1.71e-08 conditioned to 0.271
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PMS2P3 | 0.15 | 0.12 | lasso | 3 | 0.10 | 9.8e-09 | 5.6 | 5.6 | 2.6e-08 | 0.99 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | TRIM73 | 0.17 | 0.19 | lasso | 3 | 0.22 | 1.4e-11 | 5.6 | 5.3 | 8.9e-08 | 0.96 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Artery Aorta | STAG3L1 | 0.18 | 0.03 | lasso | 4 | 0.08 | 3.9e-05 | 5.1 | 5.2 | 2.1e-07 | 0.96 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | PMS2P3 | 0.19 | 0.14 | lasso | 4 | 0.19 | 3.5e-10 | 5.6 | 5.5 | 3.5e-08 | 0.91 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | POM121C | 0.17 | -0.01 | lasso | 3 | 0.02 | 6.3e-02 | 5.1 | 5.9 | 4.0e-09 | 0.87 | 0.02 | 0.30 | TRUE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | STAG3L1 | 0.36 | 0.16 | lasso | 5 | 0.16 | 1.7e-06 | 5.1 | 5.4 | 7.1e-08 | 0.91 | 0.00 | 0.99 | FALSE |
| 7 | GTEx | Esophagus Muscularis | TRIM73 | 0.12 | 0.07 | lasso | 2 | 0.05 | 3.5e-04 | 5.6 | 5.6 | 1.9e-08 | 1.00 | 0.00 | 1.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | STAG3L1 | 0.30 | 0.15 | lasso | 4 | 0.16 | 4.3e-10 | 5.1 | 5.6 | 1.8e-08 | 0.91 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Muscle Skeletal | STAG3L1 | 0.16 | 0.10 | enet | 24 | 0.10 | 3.7e-10 | 5.1 | 5.3 | 1.5e-07 | 0.82 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Nerve Tibial | TRIM73 | 0.19 | 0.20 | enet | 6 | 0.20 | 6.3e-14 | 5.1 | 5.3 | 1.4e-07 | 0.95 | 0.01 | 0.99 | FALSE |
| 11 | METSIM | Adipose | TRIM73 | 0.11 | 0.11 | lasso | 5 | 0.12 | 8.6e-18 | 5.6 | 5.3 | 9.8e-08 | 0.97 | 0.00 | 1.00 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | PMS2P2 | 0.17 | 0.08 | enet | 8 | 0.08 | 6.0e-10 | 5.1 | 5.4 | 6.0e-08 | 0.95 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POM121C | 0.08 | 0.05 | lasso | 2 | 0.05 | 6.0e-06 | 5.1 | 5.2 | 1.6e-07 | 0.95 | 0.00 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | PMS2L3 | 0.23 | 0.14 | lasso | 2 | 0.14 | 1.3e-04 | 5.1 | 5.6 | 2.3e-08 | 0.94 | 0.00 | 0.74 | FALSE |