Best TWAS P=7.74e-26 · Best GWAS P=2.12e-30 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DNAJC30 | 0.13 | 0.07 | enet | 32 | 0.07 | 2.7e-09 | 6.76 | 10.4 | 3.5e-25 | -0.20 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Brain Cortex | WBSCR27 | 0.48 | 0.34 | enet | 29 | 0.37 | 3.6e-11 | -4.42 | -5.5 | 3.4e-08 | -0.11 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Brain Hippocampus | WBSCR27 | 0.30 | 0.25 | enet | 17 | 0.23 | 3.5e-06 | -3.84 | -5.3 | 1.2e-07 | -0.16 | 0.90 | 0.01 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | MLXIPL | 0.13 | 0.06 | enet | 6 | 0.09 | 2.2e-07 | 4.54 | 5.7 | 1.6e-08 | -0.03 | 0.99 | 0.00 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | POM121B | 0.06 | 0.03 | lasso | 3 | 0.01 | 5.8e-02 | -5.11 | 5.2 | 1.8e-07 | 0.07 | 0.15 | 0.04 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | STX1A | 0.12 | 0.02 | enet | 32 | 0.02 | 1.1e-02 | -2.25 | 8.8 | 1.6e-18 | -0.17 | 0.19 | 0.14 | FALSE |
| 7 | GTEx | Spleen | NCF1B | 0.22 | 0.10 | enet | 9 | 0.08 | 5.1e-03 | 7.09 | -7.8 | 5.9e-15 | 0.06 | 0.02 | 0.62 | TRUE |
| 8 | GTEx | Testis | MLXIPL | 0.10 | 0.00 | lasso | 3 | 0.00 | 3.3e-01 | 4.67 | 5.8 | 6.2e-09 | -0.07 | 0.05 | 0.11 | FALSE |
| 9 | GTEx | Testis | VPS37D | 0.15 | 0.01 | lasso | 5 | 0.03 | 2.7e-02 | -6.80 | -7.2 | 4.7e-13 | 0.01 | 0.13 | 0.04 | FALSE |
| 10 | GTEx | Testis | SBDSP1 | 0.11 | 0.06 | lasso | 3 | 0.05 | 4.4e-03 | -5.22 | -5.2 | 2.0e-07 | -0.11 | 0.07 | 0.36 | FALSE |
| 11 | GTEx | Thyroid | MLXIPL | 0.23 | 0.14 | lasso | 7 | 0.15 | 2.1e-11 | 4.70 | 5.3 | 1.0e-07 | -0.04 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Thyroid | POM121 | 0.06 | 0.01 | enet | 13 | 0.03 | 2.5e-03 | -4.01 | -5.5 | 2.9e-08 | -0.02 | 0.09 | 0.06 | FALSE |
| 13 | METSIM | Adipose | MLXIPL | 0.12 | 0.14 | lasso | 4 | 0.13 | 1.8e-19 | 6.70 | 6.1 | 1.2e-09 | -0.02 | 1.00 | 0.00 | FALSE |
| 14 | METSIM | Adipose | TRIM50 | 0.04 | 0.00 | blup | 159 | 0.02 | 7.0e-04 | -5.21 | -10.5 | 7.7e-26 | -0.02 | 0.13 | 0.07 | TRUE |
| 15 | YFS | Blood | NSUN5 | 0.01 | 0.01 | lasso | 2 | 0.00 | 1.5e-02 | -5.35 | -5.7 | 1.6e-08 | -0.07 | 0.04 | 0.13 | FALSE |
| 16 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | STX1A | 0.03 | 0.02 | lasso | 1 | 0.01 | 2.9e-02 | -6.68 | -6.7 | 2.4e-11 | 0.03 | 0.00 | 0.82 | FALSE |
| 17 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MLXIPL | 0.06 | 0.05 | lasso | 2 | 0.05 | 5.1e-10 | 6.44 | 6.1 | 1.3e-09 | -0.02 | 0.40 | 0.60 | FALSE |
| 18 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | BCL7B | 0.08 | 0.04 | blup | 5 | 0.06 | 1.0e-03 | 6.44 | -6.1 | 8.7e-10 | 0.00 | 0.00 | 0.90 | FALSE |
| 19 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | NSUN5 | 0.59 | 0.02 | enet | 1 | 0.05 | 2.8e-03 | -5.21 | -5.2 | 1.9e-07 | -0.06 | 0.00 | 0.27 | FALSE |
| 20 | The Cancer Genome Atlas | Lung Adenocarcinoma | MLXIPL | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.3e-03 | 6.44 | 6.4 | 1.2e-10 | -0.02 | 0.02 | 0.48 | TRUE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MLXIPL | 0.08 | 0.05 | enet | 4 | 0.05 | 5.3e-06 | 6.44 | 6.3 | 3.9e-10 | 0.00 | 0.05 | 0.83 | TRUE |
| 22 | The Cancer Genome Atlas | Soft Tissue Sarcoma | NSUN5 | 0.04 | 0.03 | blup | 2 | 0.03 | 4.5e-03 | -5.07 | -5.2 | 2.6e-07 | -0.07 | 0.00 | 0.50 | FALSE |
| 23 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TBL2 | 0.16 | 0.00 | enet | 5 | 0.09 | 5.1e-06 | 0.88 | -5.9 | 4.4e-09 | 0.00 | 0.00 | 0.50 | TRUE |
| 24 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | TRIM50 | 0.13 | 0.11 | blup | 2 | 0.11 | 7.0e-04 | -5.07 | -5.2 | 2.4e-07 | -0.07 | 0.00 | 0.75 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | BCL7B | 0.05 | 0.01 | blup | 5 | 0.03 | 1.3e-03 | 6.44 | -6.8 | 8.2e-12 | 0.01 | 0.00 | 0.63 | FALSE |
| 26 | The Cancer Genome Atlas | Thyroid Carcinoma | WBSCR26 | 0.24 | 0.26 | enet | 3 | 0.28 | 6.5e-27 | -3.79 | 5.2 | 1.8e-07 | 0.13 | 1.00 | 0.00 | TRUE |