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chr7:76,506,844-78,122,616

Best TWAS P=1.9e-12 · Best GWAS P=1.66e-12 conditioned to 0.32

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	RSBN1L	0.09	0.09	enet	9	0.09	2.0e-11	-5.7	-6.0	1.8e-09	-0.74	0.86	0.14	FALSE
2	GTEx	Adipose Subcutaneous	TMEM60	0.08	0.05	lasso	4	0.05	7.3e-05	-5.3	-5.4	5.7e-08	-0.67	0.21	0.77	FALSE
3	GTEx	Adipose Visceral Omentum	TMEM60	0.20	0.13	lasso	8	0.11	2.3e-06	-6.0	-5.8	5.3e-09	-0.64	0.93	0.07	FALSE
4	GTEx	Adrenal Gland	PTPN12	0.16	0.10	lasso	4	0.04	1.0e-02	6.2	-6.2	5.9e-10	-0.76	0.11	0.76	FALSE
5	GTEx	Artery Aorta	PTPN12	0.22	0.03	enet	28	0.10	3.0e-06	-3.0	-6.9	5.0e-12	-0.69	0.02	0.98	TRUE
6	GTEx	Artery Coronary	PTPN12	0.33	0.08	enet	26	0.24	1.6e-08	-6.4	-6.9	6.2e-12	-0.72	0.02	0.97	FALSE
7	GTEx	Artery Tibial	PTPN12	0.25	0.13	lasso	8	0.12	1.8e-09	5.6	-6.2	5.3e-10	-0.83	0.33	0.67	FALSE
8	GTEx	Artery Tibial	TMEM60	0.07	0.05	enet	12	0.02	6.6e-03	-5.7	-5.2	1.6e-07	-0.62	0.03	0.92	FALSE
9	GTEx	Cells Transformed fibroblasts	TMEM60	0.25	0.20	lasso	4	0.20	1.5e-14	-5.7	-5.4	6.5e-08	-0.66	0.92	0.08	FALSE
10	GTEx	Colon Sigmoid	RSBN1L	0.17	0.09	lasso	2	0.05	5.5e-03	-5.4	-5.6	1.7e-08	-0.67	0.07	0.73	FALSE
11	GTEx	Colon Sigmoid	RSBN1L-AS1	0.46	0.48	lasso	6	0.50	5.0e-20	-5.3	-5.5	3.0e-08	-0.64	0.98	0.02	FALSE
12	GTEx	Colon Transverse	PTPN12	0.17	0.12	lasso	6	0.10	1.8e-05	6.2	-6.5	1.1e-10	-0.77	0.08	0.88	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	RSBN1L-AS1	0.38	0.41	lasso	12	0.44	1.2e-17	-6.0	-5.7	1.2e-08	-0.68	0.94	0.06	FALSE
14	GTEx	Esophagus Mucosa	TMEM60	0.06	0.04	lasso	2	0.04	1.0e-03	-5.7	-5.3	8.7e-08	-0.65	0.76	0.10	FALSE
15	GTEx	Esophagus Muscularis	PTPN12	0.34	0.17	enet	48	0.20	4.3e-12	5.9	-6.3	3.7e-10	-0.66	0.11	0.89	FALSE
16	GTEx	Esophagus Muscularis	RSBN1L-AS1	0.35	0.51	lasso	5	0.52	3.8e-36	-5.3	-5.5	3.1e-08	-0.63	0.99	0.01	FALSE
17	GTEx	Heart Left Ventricle	PTPN12	0.12	0.00	enet	21	0.01	5.6e-02	6.2	-5.5	5.1e-08	-0.48	0.04	0.39	FALSE
18	GTEx	Lung	PTPN12	0.10	0.05	enet	11	0.07	5.1e-06	6.1	-5.7	1.2e-08	-0.76	0.09	0.90	FALSE
19	GTEx	Muscle Skeletal	TMEM60	0.11	0.12	lasso	4	0.12	4.6e-12	-5.7	5.5	2.8e-08	0.68	0.91	0.09	FALSE
20	GTEx	Nerve Tibial	TMEM60	0.14	0.14	lasso	8	0.12	1.1e-08	-5.7	-5.5	3.7e-08	-0.68	0.94	0.06	FALSE
21	GTEx	Ovary	RSBN1L-AS1	0.21	0.22	enet	20	0.16	8.1e-05	-5.3	-5.7	1.1e-08	-0.61	0.25	0.27	FALSE
22	GTEx	Pancreas	PTPN12	0.26	0.13	lasso	3	0.08	2.7e-04	5.9	-5.4	7.8e-08	-0.66	0.06	0.86	FALSE
23	GTEx	Pancreas	TMEM60	0.19	0.03	enet	15	0.10	3.4e-05	-5.7	-5.1	2.7e-07	-0.60	0.02	0.90	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TMEM60	0.10	0.10	lasso	3	0.09	1.4e-07	-5.7	-5.7	9.5e-09	-0.71	0.80	0.20	FALSE
25	GTEx	Testis	RSBN1L-AS1	0.16	0.12	lasso	8	0.16	1.5e-07	-5.4	-7.0	1.9e-12	-0.87	0.04	0.96	TRUE
26	GTEx	Thyroid	PTPN12	0.13	0.08	lasso	7	0.08	9.5e-07	6.1	-6.1	1.1e-09	-0.78	0.07	0.93	FALSE
27	GTEx	Whole Blood	TMEM60	0.05	0.04	enet	7	0.03	5.4e-04	-5.7	-5.6	1.7e-08	-0.65	0.86	0.11	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF2	0.02	0.01	lasso	1	0.01	3.0e-03	5.7	-5.7	1.4e-08	-0.78	0.06	0.89	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM60	0.02	0.02	lasso	1	0.02	2.3e-05	5.9	-5.9	4.3e-09	-0.63	0.53	0.35	FALSE
30	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TMEM60	0.08	0.06	blup	29	0.05	2.1e-03	5.9	-6.8	8.3e-12	-0.72	0.01	0.48	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PHTF2	0.02	0.03	lasso	1	0.02	8.0e-04	5.6	-5.5	2.8e-08	-0.81	0.03	0.91	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TMEM60	0.05	0.01	enet	7	0.02	1.9e-03	-5.7	-6.0	2.5e-09	-0.65	0.06	0.77	FALSE
33	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMEM60	0.05	0.02	blup	29	0.03	7.9e-03	5.9	-6.8	1.5e-11	-0.73	0.02	0.47	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	RSBN1L	0.02	0.02	blup	58	0.02	3.4e-03	-5.7	5.9	4.8e-09	0.76	0.03	0.72	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM60	0.02	0.03	blup	29	0.02	6.8e-03	5.9	-6.5	1.2e-10	-0.72	0.04	0.42	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TMEM60	0.12	0.05	blup	29	0.02	3.1e-02	-5.4	-5.5	4.1e-08	-0.62	0.03	0.27	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	PTPN12	0.04	0.04	enet	4	0.04	1.0e-04	5.7	-6.0	2.1e-09	-0.75	0.09	0.84	FALSE