Best TWAS P=2.78e-37 · Best GWAS P=1.28e-38 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 12.3 | -12.7 | 3.2e-37 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RMI1 | 0.11 | 0.03 | lasso | 3 | 0.04 | 3.8e-04 | -8.5 | -7.5 | 4.9e-14 | -0.56 | 0.10 | 0.85 | FALSE |
| 3 | GTEx | Artery Aorta | GKAP1 | 0.15 | 0.02 | enet | 24 | 0.03 | 6.0e-03 | 8.9 | -11.0 | 5.0e-28 | -0.39 | 0.13 | 0.45 | TRUE |
| 4 | GTEx | Esophagus Mucosa | GKAP1 | 0.09 | 0.06 | lasso | 2 | 0.02 | 2.9e-02 | 8.9 | -8.8 | 1.0e-18 | -0.63 | 0.40 | 0.30 | FALSE |
| 5 | GTEx | Muscle Skeletal | GKAP1 | 0.07 | 0.04 | enet | 23 | 0.03 | 1.0e-03 | 8.9 | -6.7 | 2.8e-11 | -0.48 | 0.47 | 0.19 | FALSE |
| 6 | GTEx | Testis | UBQLN1 | 0.10 | 0.02 | enet | 20 | 0.04 | 1.1e-02 | 4.9 | -6.3 | 3.8e-10 | -0.28 | 0.16 | 0.35 | TRUE |
| 7 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -8.5 | -11.2 | 2.7e-29 | -0.83 | 0.02 | 0.97 | TRUE |
| 8 | METSIM | Adipose | RMI1 | 0.04 | 0.02 | lasso | 7 | 0.01 | 4.9e-03 | -8.0 | -7.7 | 1.8e-14 | -0.54 | 0.70 | 0.06 | FALSE |
| 9 | YFS | Blood | GKAP1 | 0.02 | 0.01 | blup | 614 | 0.01 | 3.2e-04 | 11.9 | -10.3 | 6.4e-25 | -0.68 | 0.02 | 0.97 | FALSE |
| 10 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | 12.7 | 12.8 | 2.8e-37 | 0.97 | 0.01 | 0.99 | TRUE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | UBQLN1 | 0.03 | 0.02 | lasso | 2 | 0.01 | 2.3e-02 | 9.6 | -8.7 | 2.8e-18 | -0.52 | 0.07 | 0.12 | TRUE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 13.0 | -12.3 | 6.0e-35 | -0.95 | 0.01 | 0.95 | FALSE |
| 13 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RMI1 | 0.05 | 0.04 | lasso | 2 | 0.00 | 1.8e-01 | -8.5 | -8.5 | 1.5e-17 | -0.60 | 0.02 | 0.20 | TRUE |
| 14 | The Cancer Genome Atlas | Colon Adenocarcinoma | RMI1 | 0.40 | 0.03 | lasso | 2 | 0.06 | 1.9e-04 | -8.4 | -7.4 | 1.5e-13 | -0.57 | 0.19 | 0.15 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 12.9 | -12.3 | 5.9e-35 | -0.93 | 0.01 | 0.97 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 12.5 | -12.7 | 3.8e-37 | -0.98 | 0.04 | 0.86 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C9orf64 | 0.07 | 0.03 | enet | 14 | 0.03 | 3.3e-04 | -8.0 | 7.2 | 7.6e-13 | 0.64 | 0.02 | 0.68 | TRUE |
| 18 | The Cancer Genome Atlas | Rectum Adenocarcinoma | UBQLN1 | 0.22 | 0.02 | lasso | 3 | 0.09 | 3.5e-03 | 9.7 | -9.6 | 7.2e-22 | -0.40 | 0.03 | 0.19 | FALSE |
| 19 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RMI1 | 0.05 | 0.06 | enet | 5 | 0.06 | 2.2e-05 | -8.0 | -10.7 | 6.6e-27 | -0.71 | 0.09 | 0.56 | TRUE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | UBQLN1 | 0.06 | 0.00 | blup | 62 | 0.02 | 1.3e-02 | -2.9 | -9.3 | 1.2e-20 | -0.42 | 0.04 | 0.11 | FALSE |
| 21 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -8.1 | 9.5 | 3.1e-21 | 0.76 | 0.02 | 0.76 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | GKAP1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.2e-06 | 8.9 | -8.9 | 8.2e-19 | -0.68 | 0.73 | 0.25 | FALSE |