Best TWAS P=2.18e-28 · Best GWAS P=3.09e-65 conditioned to 7.22e-47
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | GOLM1 | 0.17 | 0.00 | enet | 24 | 0.08 | 5.2e-05 | 1.74 | 8.4 | 5.2e-17 | -0.03 | 0.07 | 0.26 | TRUE |
| 2 | GTEx | Artery Aorta | CDK20 | 0.11 | 0.00 | enet | 12 | 0.00 | 2.4e-01 | 11.24 | 9.1 | 8.6e-20 | 0.23 | 0.06 | 0.27 | TRUE |
| 3 | GTEx | Artery Aorta | CDC20P1 | 0.23 | 0.16 | enet | 19 | 0.19 | 1.3e-10 | -3.99 | -5.3 | 1.3e-07 | 0.01 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | CDK20 | 0.11 | 0.04 | enet | 18 | 0.04 | 6.5e-03 | -0.65 | 5.5 | 4.5e-08 | 0.11 | 0.26 | 0.05 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | ZCCHC6 | 0.13 | 0.11 | lasso | 6 | 0.09 | 1.6e-07 | -8.07 | -8.2 | 1.9e-16 | 0.03 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | CDK20 | 0.28 | 0.28 | lasso | 3 | 0.29 | 4.3e-22 | -8.22 | 8.2 | 3.1e-16 | 0.07 | 1.00 | 0.00 | TRUE |
| 7 | GTEx | Esophagus Muscularis | ZCCHC6 | 0.16 | 0.08 | enet | 12 | 0.09 | 3.5e-06 | -8.13 | -8.7 | 3.5e-18 | 0.02 | 0.92 | 0.00 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | CDC20P1 | 0.23 | 0.10 | enet | 21 | 0.07 | 3.6e-04 | -3.50 | -8.4 | 2.8e-17 | -0.01 | 0.52 | 0.27 | TRUE |
| 9 | METSIM | Adipose | NAA35 | 0.05 | 0.02 | bslmm | 345 | 0.03 | 8.9e-05 | -0.44 | -6.5 | 1.1e-10 | 0.06 | 0.43 | 0.03 | FALSE |
| 10 | YFS | Blood | ISCA1 | 0.02 | 0.01 | lasso | 5 | 0.01 | 1.3e-05 | -8.07 | 9.1 | 7.9e-20 | -0.05 | 1.00 | 0.00 | TRUE |
| 11 | YFS | Blood | ZCCHC6 | 0.06 | 0.06 | lasso | 7 | 0.06 | 1.3e-17 | 8.35 | -8.4 | 3.2e-17 | 0.05 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CDK20 | 0.05 | 0.05 | lasso | 2 | 0.05 | 2.2e-11 | -8.06 | 8.1 | 4.8e-16 | 0.07 | 0.02 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ISCA1 | 0.04 | 0.01 | blup | 42 | 0.02 | 4.0e-03 | 8.16 | 6.8 | 1.0e-11 | -0.05 | 0.01 | 0.90 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | CDK20 | 0.05 | 0.02 | blup | 23 | 0.03 | 1.7e-04 | -8.22 | 8.6 | 8.4e-18 | 0.09 | 0.02 | 0.95 | TRUE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C9orf170 | 0.02 | 0.01 | blup | 63 | 0.00 | 9.8e-02 | -10.23 | 11.1 | 2.2e-28 | 0.07 | 0.01 | 0.79 | TRUE |
| 16 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CDK20 | 0.11 | 0.07 | enet | 5 | 0.07 | 9.9e-04 | -7.18 | 7.5 | 7.7e-14 | 0.07 | 0.01 | 0.37 | FALSE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CDK20 | 0.15 | 0.12 | lasso | 4 | 0.12 | 4.5e-12 | -8.06 | 7.9 | 3.8e-15 | 0.07 | 0.02 | 0.98 | FALSE |
| 18 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C9orf153 | 0.12 | 0.04 | blup | 43 | 0.05 | 7.6e-04 | -7.89 | 6.0 | 1.8e-09 | -0.01 | 0.03 | 0.66 | FALSE |
| 19 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CDK20 | 0.08 | 0.04 | blup | 23 | 0.05 | 4.7e-04 | -8.06 | 7.7 | 1.3e-14 | 0.10 | 0.02 | 0.75 | FALSE |
| 20 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ISCA1 | 0.13 | 0.13 | lasso | 3 | 0.13 | 3.3e-05 | 8.35 | 8.8 | 1.5e-18 | -0.04 | 0.01 | 0.95 | FALSE |