Hub : Genes

FMO5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1370	0.0370	2.2e-13	0.112	0.122	0.123	0.126	0.134	1.6e-13	1.3e-14	9.1e-15	4.8e-15	5.9e-16
2	GTEx	Adrenal Gland	0.2844	0.0683	5.0e-08	0.191	NA	0.203	NA	0.214	2.1e-07	NA	8.1e-08	NA	3.4e-08
3	GTEx	Artery Aorta	0.1090	0.0390	1.4e-05	0.101	NA	0.074	NA	-0.004	3.4e-06	NA	6.8e-05	NA	6.7e-01
4	GTEx	Artery Tibial	0.1017	0.0446	6.6e-04	-0.003	NA	0.017	NA	0.000	9.0e-01	NA	1.5e-02	NA	3.1e-01
5	GTEx	Cells Transformed fibroblasts	0.0800	0.0350	2.0e-03	0.000	NA	0.001	NA	0.023	2.9e-01	NA	2.5e-01	NA	7.7e-03
6	GTEx	Testis	0.2320	0.0640	4.1e-10	0.228	NA	0.242	NA	0.246	1.8e-10	NA	4.2e-11	NA	2.7e-11
7	GTEx	Thyroid	0.1670	0.0490	5.9e-09	0.137	NA	0.150	NA	0.131	1.3e-10	NA	1.4e-11	NA	3.0e-10
8	METSIM	Adipose	0.0583	0.0190	2.9e-07	0.038	0.046	0.025	0.043	0.035	2.1e-06	1.8e-07	8.7e-05	3.9e-07	4.8e-06
9	YFS	Blood	0.1217	0.0314	9.5e-15	0.025	0.054	0.052	0.062	0.046	1.1e-08	3.4e-17	1.0e-16	1.3e-19	6.7e-15
10	TCGA	Brain Lower Grade Glioma	0.0514	0.0275	8.7e-04	0.005	0.030	0.027	NA	0.019	7.0e-02	2.3e-04	4.2e-04	NA	2.4e-03
11	TCGA	Pheochromocytoma and Paraganglioma	0.1520	0.0720	3.7e-05	0.103	0.135	0.124	NA	0.128	6.8e-05	5.1e-06	1.3e-05	NA	9.1e-06
12	TCGA	Thyroid Carcinoma	0.0870	0.0370	4.1e-09	0.098	0.079	0.066	NA	0.083	8.5e-10	4.2e-08	5.6e-07	NA	1.7e-08

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	0.3	0.4	0.9	0.7	0.9	0.8	0.6	0.5	-1.0	0.6	0.3	-0.4	-0.3	0.6	0.9
Bipolar Disorder or Schizophrenia	2.7	6.5	11.6	2.5	3.4	3.4	2.2	2.9	-2.9	3.0	2.0	-0.7	-0.8	2.5	2.5
Depressed Affect (Nagel 2018)	0.2	0.5	1.5	0.3	0.7	0.0	0.1	1.0	0.8	0.1	0.8	0.8	1.2	0.8	0.4
Depression (Nagel 2018)	0.1	0.2	0.5	-0.5	-0.1	-0.7	-0.3	-0.3	0.7	-0.6	-0.0	-0.0	-0.4	-0.5	-0.4
Intelligence (Savage-Jansen 2018)	0.9	2.7	10.0	1.0	1.1	1.3	0.7	1.8	-1.2	1.5	3.2	2.1	1.2	2.0	1.2
Neuroticism (Nagel 2018)	0.2	0.5	1.4	0.1	1.2	0.2	0.3	1.1	0.0	0.5	1.1	0.6	0.6	1.0	0.6
Schizophrenia (2018)	3.6	7.6	13.7	2.7	3.6	3.7	2.3	3.3	-2.9	3.4	2.4	-0.6	-0.6	2.8	2.5
Schizophrenia vs Biploar Disorder	0.2	0.3	1.4	0.2	0.5	0.3	1.2	0.3	0.2	0.5	0.3	-0.6	-0.8	-0.3	-0.2
Worry (Nagel 2018)	0.2	0.5	1.4	-0.0	1.2	0.4	0.5	1.1	0.1	0.6	1.1	0.6	0.2	0.8	0.3
Alzheimer’s Disease (in mother)	0.9	1.0	2.6	0.1	-0.5	-0.7	0.6	-1.6	0.4	-0.3	-1.5	-1.5	-1.0	-1.4	-0.6
Alzheimer’s Disease (in father)	0.7	0.7	2.0	0.5	1.2	1.1	1.0	0.7	-1.4	0.5	0.2	-0.2	-0.6	0.8	0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	1.6	0.7	0.9	0.7	1.2	-0.4	-0.8	0.7	-0.8	-1.3	-1.0	-0.2	0.6
Crohns Disease (2017)	0.5	1.0	4.5	0.8	0.2	0.3	2.1	-0.2	-0.8	1.2	-0.7	-1.6	-1.3	-0.0	0.3
Irritable Bowel Disease (IBD)	0.3	0.6	3.1	-0.7	-0.3	-0.6	0.9	-0.0	-0.3	-0.2	0.1	-1.3	-1.8	-0.6	-0.8
Ulcerative Colitis (UC)	0.3	0.6	1.6	-1.3	-0.2	-0.7	-0.3	0.7	-0.0	-1.1	1.3	0.0	-0.9	-0.2	-1.0
Major Depression (MDD)	0.6	0.7	3.5	0.1	-0.5	-0.3	-0.9	-0.4	-0.6	-0.3	0.5	-1.8	-1.9	-0.6	-0.1
Reaction Time	0.2	0.5	1.7	-0.4	-1.0	-0.3	0.1	-0.1	0.7	-1.2	-0.2	0.4	-0.3	-0.5	-1.3
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.9	1.0	-0.1	0.6	-0.3	0.2	-1.4	0.9	1.7	0.9	0.6	1.3	0.9
Breast Cancer	0.3	0.7	3.4	-1.0	-0.6	-0.2	0.2	-0.1	-1.3	-0.3	-0.5	-0.8	-1.9	-0.0	-0.6
Ovarian Cancer	3.2	4.3	8.5	2.6	2.3	2.9	2.3	2.5	-1.3	1.8	0.8	1.4	1.0	2.7	1.9
Prostate Cancer	0.5	0.7	2.6	0.2	-0.7	-0.8	0.4	-1.2	1.6	-0.6	-1.4	-0.3	0.5	-0.6	-0.7
Age at First Birth	1.0	1.4	3.7	1.0	1.5	1.2	0.3	1.1	-0.2	0.6	0.3	1.7	1.9	1.5	1.2
Bipolar Disorder (2011)	1.0	1.0	2.2	0.8	1.3	1.4	0.7	1.5	-1.2	0.6	0.5	-0.7	-0.4	1.1	0.9
Body Mass Index (BMI) (2010)	0.7	0.9	2.8	-0.7	-1.3	-1.1	-1.7	-0.9	0.6	-1.0	-0.1	-1.1	-0.5	-0.9	-0.7
Coronary Artery Disease (CAD)	0.6	0.7	2.5	0.2	0.4	1.0	-0.6	1.2	-1.6	0.1	1.0	-0.1	-1.2	1.0	0.4
Crohns Disease (2012)	0.5	0.8	3.1	0.2	-0.2	0.4	1.3	0.1	-1.2	0.3	-0.2	-1.5	-1.8	-0.1	-0.3
Mean Putamen Volume	0.6	0.7	1.8	0.2	-0.7	-0.5	0.1	-0.7	1.2	-1.3	-1.3	0.8	0.9	-0.5	-0.4
Fasting Glucose	0.3	0.4	1.8	-1.3	-0.2	-0.3	0.1	0.4	-0.0	-1.0	0.6	0.7	-0.4	-0.3	-0.9
HbA1C	0.5	0.5	1.7	0.7	0.4	0.3	0.7	-1.1	-0.0	1.3	-0.8	0.2	0.8	-0.2	0.9
HDL Cholesterol	0.3	0.4	1.2	0.3	0.9	0.8	0.7	0.6	-0.5	1.1	0.1	-0.6	-0.7	0.4	0.5
LDL Cholesterol	0.3	0.5	2.0	-0.2	-0.2	-0.3	0.6	0.4	1.4	-0.5	-0.5	0.9	1.4	0.2	-0.7
Lupus	1.6	2.5	10.8	0.7	2.3	1.3	0.9	0.6	-1.0	1.6	0.1	-3.3	-2.0	-0.0	1.7
Neuroticism (2016)	0.6	0.9	2.6	-0.4	-0.1	-1.1	-0.6	-1.1	1.4	0.3	-1.2	-1.6	-0.5	-1.2	-0.3
Primary Biliary Cirrhosis	0.8	1.1	2.0	1.3	1.2	1.2	1.4	1.3	-0.1	0.8	0.8	0.9	0.8	1.1	0.5
Rheumatoid Arthritis	0.5	0.7	4.4	-0.1	-0.3	0.2	-2.1	0.2	-1.3	0.4	1.2	-0.4	-0.7	0.4	0.4
Schizophrenia (2014)	1.9	4.2	9.4	1.8	3.1	2.6	1.8	2.5	-1.9	2.5	2.0	-0.6	-0.6	1.8	1.9
Triglycerides	0.4	0.6	2.1	0.8	0.3	-0.1	-0.2	-1.4	-0.3	0.7	-1.2	-0.3	0.7	-0.3	1.2
Type 2 Diabetes (T2D) (2012)	0.6	0.6	2.1	-1.2	0.0	-0.3	1.1	1.2	0.1	-0.0	1.5	0.6	-0.6	0.1	-0.8
Ulcerative Colitis	0.6	0.9	4.9	-0.6	0.4	0.4	-0.5	1.5	-0.7	0.0	2.2	-0.2	-1.2	0.4	-0.4
Blood Eosinophil Count	0.0	0.4	1.0	-0.0	0.0	-0.3	1.0	-0.8	0.2	0.1	-1.0	-0.9	-0.2	-0.8	0.2
Blood Platelet Count	0.7	8.6	23.5	3.4	2.5	3.5	0.3	2.5	-4.8	2.2	3.2	0.2	-0.4	4.4	3.1
Blood Red Count	0.1	1.2	2.7	-1.6	-1.4	-1.5	0.6	-0.6	1.5	-0.3	0.1	0.8	0.5	-1.4	-1.3
Blood White Count	0.2	1.6	4.4	-2.0	-1.2	-1.3	-0.4	-0.2	0.6	-2.1	-0.5	-0.3	-1.6	-1.1	-1.9
Heel T-Score	0.0	0.3	0.9	-0.5	-0.3	-0.5	-0.2	0.3	0.7	-0.5	0.4	0.9	0.8	0.1	-0.2
BMI	0.5	2.6	5.0	-1.7	-2.2	-2.1	-1.9	-0.7	1.8	-1.3	0.5	2.0	1.6	-0.7	-1.6
Height	0.7	12.7	42.5	0.5	-3.9	-3.6	0.8	-6.5	4.1	0.0	-6.0	-1.2	2.1	-4.4	-1.5
Waist Hip Ratio (WHR)	0.3	1.3	3.7	-0.3	0.7	1.1	1.1	1.9	-1.7	-0.2	0.9	-0.5	-1.9	1.0	0.0
Systolic Blood Pressure	0.5	2.4	10.4	0.9	0.9	1.4	-0.8	2.3	-1.2	0.6	3.2	1.2	0.1	2.1	0.6
Smoking Status	0.2	0.5	2.5	0.8	-0.1	0.1	-0.4	0.2	-0.0	-1.0	-0.1	-1.6	-1.2	0.0	0.0
Allergy or Eczema	0.3	0.7	2.2	0.7	1.5	0.2	1.1	0.1	0.7	0.6	0.0	-1.3	0.2	-0.6	1.2
Cardiovascular Disease	0.2	0.7	3.5	-0.7	-0.5	-0.6	0.5	0.8	0.6	0.4	1.9	1.0	0.3	0.5	-0.8
Hypothyroidism (self reported)	0.3	0.7	2.0	-0.9	-1.1	-0.7	-1.4	-0.7	-0.2	-1.0	-0.5	-0.2	-0.9	-0.8	-0.7
Respiratory disease	1.1	2.4	4.6	-2.1	-1.4	-2.1	-0.9	-1.3	1.2	-1.4	-0.7	-1.6	-1.5	-2.0	-1.4
Type 2 Diabetes (T2D) (2018)	1.6	3.1	10.6	-1.3	1.2	0.4	2.7	3.3	0.4	-0.3	3.1	1.8	0.4	1.4	-0.7
Lung FEV1/FVC ratio	1.0	5.0	13.4	1.1	1.5	2.1	2.4	3.4	-1.2	1.6	3.7	2.9	1.1	2.7	0.7
Lung FVC	0.2	0.9	3.3	-0.1	1.4	1.2	-0.2	1.2	-1.8	0.1	0.2	-0.5	-1.1	0.9	0.8
Neuroticism	0.1	0.3	1.5	0.2	0.6	-0.3	-0.1	0.0	0.9	0.6	0.2	0.6	1.2	0.2	0.4
Chronotype (morning person)	0.2	0.5	1.4	0.9	-0.2	0.1	-0.3	-1.2	-0.7	0.4	-1.1	0.4	0.8	0.2	1.0
Hair Pigment	0.0	1.2	2.7	-0.8	-1.4	-1.4	-0.4	-1.5	1.6	-0.8	-0.4	0.9	0.9	-1.1	-1.0
Tanning	0.2	2.0	5.4	-1.8	-1.7	-1.5	-0.3	-0.5	1.1	-2.3	-1.4	-0.5	-1.1	-1.2	-2.2
Hand grip strength (left)	0.2	0.4	2.4	0.2	-0.1	0.6	-0.5	0.6	-1.5	0.5	0.4	0.2	-1.0	0.7	0.2
Number of treatments/medications taken	0.8	1.4	4.2	-1.2	-1.2	-1.9	-0.8	-0.8	2.0	-1.4	0.4	0.2	0.3	-1.1	-1.1
Average weekly spirits intake	0.6	0.7	2.1	-1.2	-0.5	-0.5	0.1	0.6	0.3	-1.4	0.6	-0.6	-1.5	-0.4	-1.2
Sensitivity / hurt feelings	0.1	0.2	0.7	-0.3	0.6	-0.1	-0.2	-0.0	-0.6	0.9	-0.2	0.4	0.2	0.3	0.7
Frequency of depressed mood in last 2 weeks	1.2	1.6	4.0	-0.6	-0.6	-1.5	-1.6	-2.0	1.9	-0.7	-1.3	-0.7	0.5	-1.8	-0.2
Hearing difficulty/problems: Yes	0.3	0.5	3.7	0.1	0.6	0.1	1.9	0.5	0.3	1.0	0.8	0.1	0.1	0.2	0.3
Relative age of first facial hair	0.1	0.2	1.2	0.5	0.1	0.3	0.6	-0.2	-0.2	1.1	-0.4	0.1	0.6	-0.0	0.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.3	-0.9	-1.3	-1.5	-1.4	-0.9	1.0	-1.2	-0.2	-1.0	-1.4	-1.3	-1.1
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.3	0.5	-0.9	-0.9	-0.4	-1.6	1.6	-0.7	-1.8	-0.5	0.7	-1.1	-0.5
Ever had hysterectomy (womb removed)	0.3	0.3	0.7	0.6	-0.5	-0.5	-0.8	-0.8	0.8	-0.1	-0.3	-0.6	0.0	-0.6	-0.2
Systolic blood pressure, automated reading	0.4	1.2	6.7	-0.3	-0.2	0.2	-1.2	1.7	-0.3	-0.4	2.6	0.9	-0.3	1.0	-0.7
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.6	-0.1	1.0	0.7	-0.1	0.5	-1.0	0.1	-0.4	-1.3	-1.3	-0.1	0.6
Angina	2.3	3.1	5.8	-1.8	-2.1	-2.4	-1.4	-1.9	2.2	-2.0	-1.4	0.2	-0.2	-1.9	-1.9
Medication for hormone replacement therapy	0.9	1.0	2.6	1.6	1.4	1.4	0.3	0.2	-1.0	0.7	-1.1	-0.7	-0.3	0.5	1.4
Vitamin and mineral supplements	1.1	1.5	3.8	0.8	1.4	1.2	0.1	1.2	-1.4	1.2	1.5	0.6	0.7	1.9	1.5
Supplements: Zinc	1.7	1.8	5.2	-1.0	-0.7	-1.2	-1.5	-1.9	1.6	-0.5	-2.3	-0.3	0.3	-2.2	-0.5
Medication: Co-codamol	0.4	0.5	2.4	0.3	-0.0	-0.3	-0.4	-0.2	1.2	-0.3	0.2	1.1	1.5	-0.4	0.0
Medication: Metformin	1.1	1.5	5.3	-1.8	-0.9	-1.2	-1.1	0.3	1.2	-2.3	1.1	0.1	-0.7	-0.9	-1.4
Diabetes (father)	0.8	1.0	3.1	-0.6	0.8	0.8	1.5	1.8	-0.4	-0.1	1.7	-0.2	-1.2	0.5	-0.4
Diabetes (mother)	0.3	0.4	1.1	-0.6	-0.8	-0.7	-0.8	-0.3	0.3	-1.0	0.2	0.3	-0.3	-0.3	-0.9
Severe depression (siblings)	2.5	2.8	4.8	-1.7	-1.9	-2.2	-0.8	-1.9	1.3	-1.5	-1.2	-1.9	-1.4	-2.2	-1.5
Pack years adult smoking proportion	3.2	4.8	9.3	-2.3	-2.6	-2.3	-2.6	-2.4	1.2	-2.4	-1.3	-1.3	-2.0	-3.1	-2.1
Impedance of leg (right)	0.2	1.2	3.0	0.9	1.1	1.4	0.6	1.5	-1.1	0.9	1.7	0.6	0.1	1.4	0.6
Leg fat-free mass (left)	1.0	5.2	13.2	-0.8	-3.1	-2.8	-0.8	-3.6	2.9	-1.1	-3.0	0.3	1.3	-2.8	-1.7
Trunk fat percentage	0.9	3.5	9.2	-1.5	-3.0	-2.5	-0.6	-1.3	2.6	-1.7	0.0	1.8	1.2	-1.3	-2.4
Hand grip strength (right)	0.2	0.4	1.8	-0.5	-1.3	-0.4	-0.9	0.2	0.0	-0.4	0.1	1.3	0.2	0.2	-0.8
Townsend deprivation index at recruitment	0.3	0.5	2.0	-0.2	-0.5	-0.6	0.3	-0.6	1.4	0.0	-0.5	0.4	1.4	-0.7	-0.1
Current tobacco smoking	2.0	3.3	7.9	-1.6	-2.3	-2.1	-1.8	-1.3	1.7	-2.8	-1.4	-1.1	-1.0	-2.0	-2.1
Average weekly fortified wine intake	0.4	0.4	1.5	0.1	0.4	-0.0	0.3	-0.7	0.7	0.4	-1.1	0.7	1.2	-0.5	0.6
Maternal smoking around birth	0.8	1.1	3.7	-1.2	-1.2	-0.9	-0.3	-0.5	0.2	-1.4	-0.4	-0.9	-1.9	-1.0	-1.3
Fed-up feelings	0.6	1.0	4.0	-0.9	-1.0	-1.4	-0.6	-0.3	2.0	-1.3	0.2	0.5	0.7	-0.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.2	-0.9	-1.3	-1.3	-1.2	-1.7	1.4	-1.2	-1.8	1.0	0.7	-1.1	-1.1
Relative age voice broke	0.1	0.1	0.3	0.6	-0.3	0.2	0.4	-0.5	-0.4	0.1	-0.5	-0.3	-0.2	-0.1	0.2
Taking other prescription medications	2.1	3.2	8.8	-2.0	-1.8	-3.0	-0.5	-1.4	2.8	-2.0	-0.0	-0.3	0.2	-1.9	-1.9
Age when periods started (menarche)	2.4	5.9	9.1	2.8	2.9	2.8	2.6	2.0	-2.9	2.6	1.8	-0.1	0.2	3.0	2.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.5	0.9	0.5	0.3	-0.1	0.2	-0.2	1.0	0.1	-1.2	-0.3	0.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.4	-0.5	-0.7	-1.0	-0.8	-1.2	1.5	-0.3	-0.6	0.5	1.0	-1.2	-0.4
Tinnitus: Yes, but not now, but have in the past	0.1	0.2	0.8	-0.4	0.1	0.2	0.3	0.5	0.1	-0.6	0.3	0.9	0.2	0.0	-0.3
Qualifications: CSEs or equivalent	0.9	1.2	3.9	-0.9	-2.0	-1.2	-1.4	-0.8	-0.0	-1.6	-0.6	-0.4	-0.9	-0.6	-1.3
Serious illness, injury or assault to yourself	5.3	6.4	12.1	-2.9	-3.5	-3.3	-3.1	-2.3	2.0	-2.9	-1.0	-1.2	-1.3	-2.8	-2.4
High blood pressure	0.3	0.8	2.1	-0.7	-1.1	-0.9	-1.2	-0.1	1.4	-0.5	0.5	0.6	0.3	-0.5	-1.3
Hayfever, allergic rhinitis or eczema	0.3	0.7	3.0	0.9	1.7	0.7	0.4	0.5	0.3	0.6	0.1	-0.8	0.5	-0.1	1.4
Multivitamins +/- minerals	0.7	0.9	2.1	-0.9	-0.7	-0.4	1.1	-0.1	0.7	-1.3	-1.4	0.1	-0.7	-1.1	-1.4
Stomach or abdominal pain in last month	0.4	0.5	1.3	-0.4	0.4	0.1	1.0	1.2	-0.2	-0.1	1.1	-0.5	-1.1	0.3	-0.2
Supplements: Glucosamine	0.3	0.4	2.1	-0.5	-0.0	-0.3	-0.4	0.4	0.4	0.4	1.0	1.4	0.7	0.2	-0.4
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	2.3	0.5	0.3	0.7	-1.2	-0.1	-1.1	0.4	0.4	-1.1	-1.5	-0.2	0.5
Medication: Atenolol	0.3	0.4	1.8	1.0	0.5	0.5	-1.4	0.4	-0.0	0.2	0.2	-0.2	0.5	0.8	0.6
Medication: Levothyroxine sodium	0.6	1.0	3.1	0.8	0.3	1.1	-0.2	1.0	-1.8	1.0	1.4	0.4	-0.3	1.4	0.9
Sitting height	0.4	2.6	7.7	0.1	-2.1	-1.4	0.0	-2.7	0.4	0.1	-2.8	-2.3	-0.9	-1.8	-0.8
Chronic bronchitis/emphysema (father)	1.4	1.7	3.7	-1.2	-1.3	-1.4	-0.4	-1.2	0.7	-1.1	-1.9	-1.0	-1.5	-1.5	-1.5
High blood pressure (mother)	1.2	1.6	4.6	-1.8	-1.5	-1.1	-2.0	-0.4	0.5	-2.1	-0.3	1.4	0.4	-0.5	-1.3
Body mass index (BMI)	0.7	2.9	6.4	-1.9	-2.5	-2.1	-1.6	-0.7	1.8	-2.0	0.6	2.0	0.8	-0.9	-2.2
Impedance of leg (left)	0.3	1.7	3.9	0.9	1.2	1.5	0.8	1.9	-1.3	1.1	2.0	0.8	0.1	1.8	0.7
Leg predicted mass (left)	0.9	5.0	13.0	-0.7	-3.1	-2.7	-0.7	-3.6	2.8	-1.0	-3.0	0.2	1.2	-2.7	-1.6
Trunk fat mass	1.2	5.3	13.0	-1.7	-3.6	-3.1	-0.9	-2.3	3.2	-1.8	-0.8	1.6	1.4	-2.2	-2.7
Waist circumference	1.0	3.6	8.9	-2.1	-3.0	-2.5	-0.8	-1.4	2.1	-2.0	-0.5	1.4	0.4	-1.7	-2.6
Number of incorrect matches in round	0.4	0.6	1.8	-0.1	-0.7	-0.1	-1.3	-0.1	1.1	-1.1	-1.3	-0.1	0.1	-0.7	-0.6
Past tobacco smoking	0.7	1.3	3.9	-2.0	-1.3	-1.1	-1.6	-0.1	0.3	-1.4	0.3	0.5	-0.6	-0.9	-1.6
Alcohol usually taken with meals	0.2	0.3	1.3	1.1	0.8	0.6	0.6	-0.0	-0.0	0.3	0.0	-0.3	0.5	0.1	0.7
Nervous feelings	0.1	0.2	1.1	0.0	1.0	0.0	0.2	0.5	0.4	0.4	-0.2	0.2	0.6	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.3	1.1	-0.0	-0.1	-1.1	-1.0	-0.0	0.4	-0.7	-0.3	0.3	-0.0	0.7
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.0	0.3	-0.1	0.9	-0.1	0.7	0.1	-0.1	0.5	0.7	-0.1	0.2
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	1.0	0.2	0.1	-0.7	-0.6	-0.4	0.8	0.4	-0.2	0.6	0.4	1.0
Had menopause	0.8	1.0	2.6	1.5	0.6	0.9	1.3	0.6	-0.9	1.6	0.4	-1.2	-0.6	0.9	0.7
Had other major operations	1.9	2.3	4.3	-1.6	-1.5	-1.8	-0.4	-0.6	1.5	-1.6	-0.9	-1.4	-1.6	-2.0	-2.1
Forced vital capacity (FVC)	0.2	0.6	1.6	1.3	0.6	0.9	0.2	-0.3	-0.9	0.8	-1.2	-0.9	-0.1	0.3	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.5	0.1	-0.3	-0.5	-0.6	-1.2	0.9	-0.2	-0.5	0.8	1.2	-0.7	0.3
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.4	-0.6	-0.4	-0.3	-0.2	-0.5	-0.2	-0.9	-0.8	-0.5	-1.2	-0.7	-0.4
Qualifications: None of the above	0.3	0.7	2.3	-1.5	-0.5	-1.1	0.0	0.5	1.0	-1.0	0.7	0.8	0.3	-0.1	-1.1
Financial difficulties in last 2 years	0.2	0.3	1.0	0.9	0.3	0.5	-0.2	0.3	0.1	-0.0	-0.1	0.9	1.0	0.2	0.7
Mouth/teeth dental problems	0.4	0.6	3.4	0.3	0.1	1.0	0.7	0.6	-1.0	0.0	-0.6	-0.9	-1.8	-0.0	-0.5
Heart attack	0.5	0.6	2.0	-0.5	-0.8	-0.4	-1.2	0.3	0.1	-1.4	0.1	-0.7	-1.3	-0.3	-0.7
Allergy	0.4	0.8	3.2	0.8	-0.4	0.8	0.0	0.7	-1.0	0.2	0.4	1.8	0.6	1.7	-0.1
Pain all over the body in last month	1.1	1.2	3.1	-1.4	-1.5	-1.8	0.1	-0.8	1.2	-0.8	0.6	-0.6	-0.5	-1.1	-1.4
Diabetes (self-reported)	1.1	1.7	5.0	-1.7	0.5	-0.1	1.7	2.0	0.5	-0.9	2.2	1.8	0.1	0.4	-1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	2.3	0.2	0.9	0.2	1.5	0.3	0.4	0.3	-0.3	-0.1	0.2	-0.2	0.3
Medication: Ramipril	0.3	0.4	2.1	0.8	0.2	0.2	-0.7	-0.0	0.9	-0.3	-0.2	0.5	1.5	0.1	0.3
Medication: Simvastatin	0.6	0.9	3.1	0.1	1.6	0.9	1.8	1.4	-0.4	0.6	0.5	-0.1	-0.4	0.8	0.7
Fluid intelligence score	0.8	1.7	3.3	0.9	1.0	1.2	1.1	0.8	-1.6	1.5	1.8	1.6	1.0	1.4	1.4
Illnesses of siblings	1.1	1.6	4.5	2.1	1.2	1.3	0.7	-0.9	-1.1	1.5	-1.3	-0.4	0.8	0.4	2.0
Neuroticism score	0.1	0.3	1.2	-0.1	0.5	-0.5	0.1	-0.0	1.0	0.4	0.1	0.4	1.1	0.1	0.2
Weight	1.0	5.0	12.7	-1.6	-3.6	-3.0	-1.2	-2.7	2.9	-1.7	-1.5	1.1	1.2	-2.3	-2.5
Impedance of arm (right)	0.1	0.6	1.7	0.5	0.5	0.6	1.2	0.8	-1.0	0.3	0.4	-1.3	-0.8	0.7	0.4
Arm fat percentage (right)	0.8	3.2	7.4	-2.2	-2.7	-2.3	-0.7	-0.5	2.0	-2.3	0.6	1.7	0.5	-1.1	-2.6
Trunk fat-free mass	0.7	4.1	13.2	-0.4	-2.5	-2.3	-0.8	-3.6	2.2	-0.5	-3.0	-0.5	0.7	-2.7	-1.2
Hip circumference	1.3	5.6	13.3	-1.6	-3.6	-3.3	-1.4	-3.0	2.9	-1.8	-1.6	1.0	1.1	-2.5	-2.6
Time employed in main current job	1.3	1.5	2.6	1.2	1.5	1.1	1.5	1.4	1.0	1.6	0.5	0.6	1.6	0.9	0.9
Alcohol intake versus 10 years previously	2.3	3.5	9.2	-0.9	-2.3	-2.2	-0.4	-1.9	3.0	-2.0	-1.7	1.3	1.6	-1.8	-1.8
Father’s age at death	0.3	0.5	1.4	1.2	0.4	0.6	1.1	0.3	-0.6	0.9	0.4	-0.3	0.1	0.8	0.5
Worrier / anxious feelings	0.1	0.2	1.0	0.0	0.5	0.1	0.1	0.5	0.5	0.1	1.0	-0.1	-0.3	0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	-0.2	0.8	0.0	-0.0	0.3	-0.6	0.1	0.7	0.3	0.0	0.5	0.7
Falls in the last year	3.0	4.1	9.4	-2.7	-2.2	-3.1	-2.5	-2.4	1.3	-2.1	-0.6	-1.3	-0.9	-2.2	-1.4
Hair/balding pattern: Pattern 3	0.5	0.8	1.8	1.1	1.4	1.0	0.6	0.4	0.0	0.8	-0.5	1.2	1.0	0.7	0.9
Number of live births	1.6	2.2	8.2	-0.5	-0.2	1.1	-0.7	2.6	-1.2	-0.2	2.9	2.1	-0.4	1.8	-0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	1.6	1.1	1.0	1.3	1.0	0.9	-1.1	1.1	0.3	0.3	0.4	1.2	1.1
Pulse rate	1.4	2.4	7.0	0.5	1.7	1.5	1.0	2.6	-1.3	0.7	2.7	0.8	0.3	2.2	1.0
Happiness	0.3	0.3	1.0	-0.1	-0.2	-0.1	0.1	0.4	1.0	-0.7	0.8	0.9	0.4	0.0	-0.8
Noisy workplace	1.6	1.9	8.1	0.1	0.9	1.0	0.1	2.8	0.4	-0.2	2.7	1.8	0.8	1.4	-0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.2	1.1	-0.0	0.3	0.4	0.1	-0.2	-0.4	0.2	-1.0	-0.7	-0.6	-0.6	0.0
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	3.7	-0.6	0.6	0.6	0.2	1.7	-1.1	-0.4	1.9	1.0	-0.5	1.2	-0.1
Mouth/teeth dental problems: Dentures	1.5	2.6	6.5	-2.2	-1.8	-2.5	-1.6	-1.3	1.7	-1.9	0.2	-0.1	-0.2	-1.9	-1.5
Asthma	1.1	2.1	4.7	-2.0	-0.9	-1.7	-1.1	-1.5	0.1	-0.9	-0.2	-2.2	-2.1	-1.9	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	4.1	-0.7	-1.4	-1.7	-1.5	-2.0	1.1	-1.0	-1.8	-0.9	-0.5	-1.7	-0.8
Medication: Cholesterol lowering	0.2	0.3	2.1	-0.5	0.5	-0.3	1.5	0.3	0.8	-0.3	0.0	-0.0	-0.2	-0.4	-0.1
Depression (self-reported)	0.5	0.6	2.8	-0.9	-0.2	-0.9	0.1	-0.1	1.7	-0.7	-0.3	0.0	0.5	-1.1	-0.6
Medication: Lansoprazole	2.3	2.6	6.6	-2.4	-2.0	-2.1	-1.1	0.0	1.9	-1.9	1.0	0.9	-0.2	-1.1	-2.6
Prospective memory result	0.4	0.5	1.1	0.9	0.3	0.5	-0.8	0.4	-0.5	0.6	-0.0	0.6	1.1	1.1	0.7
Lung cancer (father)	1.5	1.8	3.9	-1.5	-2.0	-2.0	-0.8	-1.0	1.4	-1.6	-0.1	1.0	0.8	-0.7	-1.8
Illnesses of mother	2.2	2.7	5.1	2.1	1.6	1.8	2.2	1.3	-1.8	2.3	0.4	-0.4	0.1	1.8	1.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.9	1.3	1.6	1.6	1.8	1.0	-1.5	2.0	0.0	0.4	0.6	1.3	1.6
Pulse wave Arterial Stiffness index	0.3	0.4	2.4	-0.6	-0.4	-0.4	-1.6	-0.1	-1.0	-0.1	0.5	0.1	-0.5	0.2	0.1
Impedance of arm (left)	0.2	0.9	2.3	1.2	0.8	0.8	1.5	0.4	-0.9	1.1	-0.2	-1.5	-0.6	0.6	0.9
Arm fat mass (right)	0.9	3.6	9.3	-1.8	-3.0	-2.6	-1.1	-1.4	2.3	-1.9	-0.1	1.6	0.8	-1.6	-2.5
Trunk predicted mass	0.7	4.0	13.0	-0.3	-2.4	-2.2	-0.7	-3.6	2.1	-0.4	-3.1	-0.5	0.8	-2.7	-1.1
Standing height	0.6	5.6	19.6	0.7	-2.5	-2.2	0.4	-4.4	2.3	0.6	-4.3	-1.7	0.9	-2.8	-0.6
Length of working week for main job	1.4	1.5	3.4	1.4	1.0	1.1	1.0	1.0	-0.9	1.1	0.8	1.2	1.7	1.9	1.3
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.9	-0.0	0.3	0.1	-0.4	0.4	-0.4	-1.1	0.6	0.8	-0.1	0.1
Breastfed as a baby	0.4	0.6	4.1	0.4	0.2	0.2	2.0	0.7	0.0	0.6	1.1	-0.1	0.2	0.4	-0.1
Tense / ‘highly strung’	0.1	0.2	0.9	0.1	1.0	-0.0	-0.5	-0.1	0.5	0.3	-0.2	-0.4	0.3	-0.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.0	-1.4	-0.4	-1.2	-1.2	-0.0	1.2	-0.2	0.8	-0.9	-1.0	-1.0	-1.0
Hair/balding pattern: Pattern 4	1.3	3.2	8.7	-3.0	-1.6	-1.7	0.1	0.3	1.8	-2.2	-0.2	-1.0	-1.8	-1.9	-2.9
Birth weight of first child	0.6	1.0	3.5	-0.1	-0.5	-1.2	0.2	-1.9	0.6	0.6	-1.1	-1.8	-0.2	-1.3	0.1
Peak expiratory flow (PEF)	0.1	0.3	1.2	0.1	0.4	0.6	0.9	0.4	-1.1	0.5	0.5	-0.1	-0.7	0.5	0.4
Pulse wave reflection index	2.4	2.9	5.9	-2.4	-2.0	-2.0	-1.9	-1.6	0.4	-1.7	-1.4	-0.6	-1.6	-2.1	-1.8
Ever highly irritable/argumentative for 2 days	0.5	0.6	2.3	-0.2	-0.3	-0.7	-0.7	-0.7	1.0	-0.4	-0.0	1.5	1.5	-0.2	-0.2
Loud music exposure frequency	1.0	1.1	4.9	1.0	0.3	0.4	1.4	-0.5	0.5	-0.0	-1.1	1.8	2.2	0.1	0.6
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	3.7	0.8	0.7	0.9	1.8	0.6	-0.4	1.9	0.8	0.7	0.5	0.5	0.6
Mouth/teeth dental problems: Bleeding gums	1.8	2.4	7.3	1.9	1.1	1.1	-0.0	0.9	0.0	1.8	1.3	1.9	2.7	1.8	1.6
Blood clot in the leg (DVT)	0.4	0.5	2.2	-0.6	-0.4	-0.9	0.3	-0.8	1.5	0.0	-0.1	-0.4	0.7	-1.0	-0.3
Medication: Paracetamol	1.1	1.8	8.2	-1.0	-1.0	-1.6	-0.9	-0.6	2.9	-1.1	-0.1	0.9	1.2	-1.3	-1.3
Headache pain in last month	0.1	0.2	0.8	-0.3	-0.1	-0.2	-0.5	0.2	0.8	-0.2	-0.1	0.9	0.9	0.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.7	1.3	0.4	0.9	-0.2	-0.5	-1.3	1.0	-0.3	-0.0	0.3	0.7	1.1
Glaucoma (self-reported)	0.1	0.1	0.4	-0.6	-0.0	-0.6	-0.0	-0.1	0.3	0.6	0.3	-0.2	0.0	-0.2	-0.0
Gout (self-reported)	0.6	0.8	3.2	0.4	0.1	0.2	0.8	0.3	1.2	1.3	0.4	1.4	1.8	0.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.9	-0.9	-1.4	-0.5	-1.4	0.1	-0.3	-1.2	0.6	0.3	-0.9	-0.1	-1.0
Medication: Amlodipine	0.1	0.1	0.5	-0.2	0.2	-0.2	0.7	0.3	0.2	-0.6	-0.4	0.2	0.4	0.3	-0.0
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.6	-1.0	-1.2	-1.5	-1.0	-2.0	0.1	-0.7	-1.2	-2.1	-1.6	-1.6	-0.4
Birth weight	0.2	0.4	1.1	0.4	-0.2	-0.7	0.6	-1.0	0.8	1.0	-0.4	-0.2	1.0	-0.3	0.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.7	0.4	0.3	0.2	-0.8	-0.5	-0.5	0.4	-0.7	-0.8	-0.6	-0.0	0.3
High blood pressure (siblings)	1.1	1.5	4.0	-2.0	-1.0	-0.9	-0.8	1.2	0.4	-1.4	1.3	-0.4	-1.6	-0.4	-1.9
Forced vital capacity (FVC), Best measure	0.3	1.0	2.4	1.4	1.0	1.1	0.8	-0.2	-1.1	1.6	-1.2	-0.5	0.3	0.5	1.4
Body fat percentage	0.9	3.5	8.7	-1.9	-3.0	-2.4	-0.7	-0.8	2.3	-1.9	0.5	2.0	0.9	-1.2	-2.6
Leg fat percentage (right)	1.0	3.6	7.2	-2.1	-2.7	-2.1	-1.2	-0.3	2.1	-2.0	1.3	2.5	0.9	-0.9	-2.7
Arm fat-free mass (right)	0.9	4.5	12.7	-0.5	-2.7	-2.4	-0.9	-3.6	2.7	-0.4	-2.8	0.5	1.4	-2.7	-1.4
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.6	-0.4	-0.0	0.4	-0.1	0.0	0.0	0.5	0.3	0.1	0.3	0.0
Comparative body size at age 10	0.4	1.1	4.5	0.3	-0.4	-0.4	-2.1	-1.8	0.3	-0.3	-1.9	-0.6	-0.1	-1.2	0.2
Number of full brothers	0.1	0.2	0.6	-0.3	-0.8	0.0	-0.3	0.1	-0.6	0.2	-0.0	0.8	0.0	0.5	-0.3
Worry too long after embarrassment	0.1	0.2	0.6	0.0	0.6	0.2	0.1	0.2	-0.6	0.4	0.2	-0.7	-0.8	0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	1.5	0.1	0.2	-0.4	0.5	-0.3	1.2	-0.0	-0.1	0.3	0.6	-0.4	-0.0
Wheeze or whistling in the chest in last year	2.2	3.9	7.9	-1.9	-1.9	-2.8	-2.2	-2.4	2.4	-1.8	-1.2	-1.1	-0.4	-2.7	-1.6
Number of children fathered	1.5	1.7	7.8	-1.2	-0.8	-0.5	-1.7	-0.3	-1.0	-0.1	0.3	-2.0	-2.8	-0.9	-0.8
Reason for reducing amount of alcohol drunk: Health precaution	3.1	3.6	8.4	2.0	2.9	2.3	2.7	1.3	-1.4	2.4	0.4	-1.2	-0.2	1.2	2.4
Age at first live birth	0.5	0.8	2.9	0.6	1.6	1.0	1.7	0.6	-0.3	1.2	-0.7	-0.3	0.1	0.4	0.8
Pulse wave peak to peak time	0.5	0.5	2.8	0.9	0.2	0.4	1.7	-0.3	1.1	0.3	-0.9	-0.2	0.6	-0.3	-0.0
Health satisfaction	0.3	0.3	1.1	-0.2	-0.3	-0.3	-0.9	0.7	0.3	-0.7	1.1	-0.1	-0.6	0.5	-0.6
Shortness of breath walking on level ground	2.4	2.8	6.0	-1.6	-1.5	-2.0	-1.1	-2.2	1.8	-1.5	-2.5	-0.7	-0.3	-2.2	-1.4
Qualifications: College or University degree	1.4	4.5	8.8	2.2	2.3	2.5	2.1	0.6	-3.0	2.9	-0.3	-2.4	-1.4	1.2	2.6
Eye problems/disorders: None of the above	0.9	1.1	4.0	0.8	0.7	0.5	0.8	0.5	-0.1	0.5	0.9	1.8	2.0	1.2	0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.9	1.0	1.4	0.9	0.4	0.6	-0.9	1.1	1.5	0.5	0.9	1.3	1.7
Emphysema/chronic bronchitis	1.8	2.0	4.3	-1.2	-0.9	-1.4	-1.2	-1.4	1.1	-1.5	-1.7	-2.0	-1.2	-2.1	-0.7
Medication for pain relief, constipation, heartburn	1.4	2.3	7.5	1.3	1.5	2.0	1.0	1.4	-2.7	1.6	0.9	0.2	-0.2	1.9	1.5
Neck or shoulder pain in last month	0.2	0.3	0.8	0.2	0.7	-0.4	0.4	-0.4	0.9	0.3	-0.7	-0.3	0.3	-0.7	0.6
Medication: Blood pressure	1.3	2.3	4.8	-1.9	-1.7	-1.8	-1.9	-0.2	2.1	-2.2	-0.0	0.5	0.1	-1.2	-1.9
Angina (self-reported)	2.0	2.6	4.8	-1.5	-2.0	-2.2	-1.4	-1.8	1.8	-2.0	-1.5	0.3	-0.1	-1.6	-1.6
Migraine (self-reported)	1.4	1.7	5.5	1.1	1.0	1.2	1.2	1.4	0.2	0.4	1.9	2.3	1.7	1.3	0.5
Medication: Ibuprofen	2.4	2.8	6.3	-1.0	-1.8	-2.2	-1.7	-2.5	1.3	-1.5	-1.8	-1.5	-0.9	-2.0	-1.1
Medication: Allopurinol	0.3	0.4	1.5	-0.1	-0.7	-0.3	-0.6	0.0	1.2	0.1	0.4	0.8	1.1	-0.3	-0.6
Medication: Omeprazole	0.5	0.5	2.1	0.2	0.9	0.8	-0.2	1.5	0.0	-0.0	1.4	0.3	0.3	0.7	0.4
Medication: Seretide 50 evohaler	2.0	2.3	5.6	-1.4	-1.8	-1.9	-1.6	-2.4	0.4	-0.6	-1.6	-1.4	-1.0	-2.0	-0.8
Mean time to correctly identify matches	0.7	1.4	4.1	-1.1	-1.4	-1.1	0.3	-0.5	1.7	-1.6	-0.9	0.2	-0.4	-1.3	-2.0
Heart disease (mother)	0.5	0.6	3.1	-0.5	0.0	-0.6	-0.5	0.2	0.4	-0.4	1.1	-1.8	-1.4	-0.4	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	1.8	-0.9	-1.3	-0.9	-1.3	-0.0	0.6	-0.9	1.0	-0.8	-1.4	-0.7	-1.2
Whole body fat mass	1.2	4.8	12.2	-1.8	-3.5	-3.0	-1.1	-2.2	2.8	-2.0	-0.8	1.5	1.0	-2.1	-2.7
Leg fat mass (right)	1.1	4.3	10.0	-2.0	-3.2	-2.7	-1.4	-1.4	2.6	-2.0	0.2	2.2	1.2	-1.6	-2.6
Arm predicted mass (right)	0.9	4.7	13.6	-0.4	-2.8	-2.4	-0.9	-3.7	2.7	-0.4	-3.0	0.5	1.3	-2.8	-1.4
Pulse rate, automated reading	1.1	3.7	12.3	0.6	1.7	1.7	1.8	2.9	-2.2	0.7	3.5	-0.9	-1.9	2.2	0.8
Alcohol intake frequency.	1.6	3.7	10.6	-2.1	-1.9	-2.7	-1.8	-1.7	3.2	-1.2	-0.1	1.3	1.7	-2.1	-1.6
Comparative height size at age 10	2.7	14.8	35.3	-1.7	-4.5	-4.4	-2.3	-5.9	4.7	-1.7	-5.7	-1.3	0.9	-5.2	-2.7
Number of full sisters	0.6	0.8	2.4	-1.5	-0.8	-0.8	0.0	0.5	0.1	-1.0	1.1	0.5	-1.1	-0.3	-1.3
Suffer from ‘nerves’	0.2	0.3	0.7	-0.6	0.8	-0.1	0.4	0.6	0.2	0.5	0.5	-0.5	-0.7	-0.1	-0.1
Overall health rating	0.3	0.6	3.0	-0.9	-0.5	-0.8	-0.0	0.5	0.8	-0.6	1.7	0.7	-0.1	0.0	-0.8
Chest pain or discomfort	0.2	0.2	0.6	0.1	-0.5	-0.7	-0.7	-0.5	0.7	-0.2	0.6	-0.2	-0.0	-0.5	0.0
Had major operations	0.7	0.8	1.8	-0.8	-1.3	-1.3	-0.0	-0.3	1.3	-1.3	0.3	0.4	0.1	-0.5	-1.3
Age at last live birth	0.3	0.4	1.8	-0.4	0.6	0.2	1.3	0.2	0.1	0.5	-0.9	-0.8	-0.8	-0.5	-0.0
Family relationship satisfaction	0.1	0.1	0.6	0.1	-0.0	-0.2	-0.2	-0.8	0.5	-0.2	0.2	0.1	0.3	-0.5	0.1
Leg pain on walking	0.8	1.1	2.9	-1.1	-0.9	-1.6	-0.5	-0.6	1.7	-1.3	-0.7	0.4	0.4	-0.9	-1.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	7.2	-0.2	-1.3	-1.1	-2.7	-1.3	0.9	-0.8	-0.9	1.0	1.4	-0.7	-0.3
Commuting to job workplace: Car/motor vehicle	1.9	2.2	4.5	-2.0	-1.9	-1.8	-2.1	-0.9	1.0	-2.0	-0.2	0.4	-0.4	-1.2	-1.9
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.3	0.1	0.1	0.0	-0.0	0.2	0.1	0.3	-0.1	-0.6	0.0	0.1	-0.1
Medication: Aspirin	0.6	0.7	2.3	0.1	-0.4	-0.5	1.3	-1.3	0.8	-0.3	-1.5	-0.8	-0.2	-1.2	-0.1
Supplements: Vitamin C	0.7	0.8	1.9	-1.1	-1.1	-0.8	-1.0	-0.1	0.1	-0.7	1.4	-0.2	-1.2	-0.7	-1.1
Knee pain experienced in last month	1.8	2.8	4.4	-2.1	-2.1	-1.9	-1.5	-1.2	2.0	-1.7	-1.3	1.3	0.4	-1.5	-2.1
Hypertension (Self-reported)	0.4	1.2	3.8	-1.1	-1.3	-1.3	-0.9	-0.1	1.9	-0.7	0.5	0.7	0.4	-0.7	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	8.8	1.0	1.6	1.7	0.6	2.7	-1.2	1.0	3.0	0.8	0.2	2.3	0.9
Illnesses of father: Heart disease	1.8	2.5	5.5	-1.9	-1.2	-1.5	-1.9	-1.1	1.4	-1.9	-0.9	-1.3	-1.4	-2.4	-1.6
Illnesses of siblings: Diabetes	1.2	1.4	3.2	-1.5	-0.3	-0.6	0.2	1.6	1.2	-1.5	1.8	1.5	0.5	0.3	-1.5
Smoking status: Previous	1.5	2.2	5.2	2.3	1.9	1.7	1.7	0.7	-0.9	2.1	0.4	-0.2	0.6	1.4	2.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.0	1.0	-0.8	-0.5	-0.6	-1.7	0.2	0.7	-1.4	-1.6	-0.3	-0.8	0.3
Whole body fat-free mass	1.0	5.5	15.4	-0.7	-3.0	-2.7	-0.9	-3.9	2.7	-0.9	-3.4	-0.1	1.1	-3.0	-1.6
Leg fat-free mass (right)	0.9	4.8	12.8	-0.7	-3.0	-2.6	-0.7	-3.6	2.6	-0.8	-3.2	0.0	1.1	-2.6	-1.5
Arm fat percentage (left)	0.6	2.5	6.1	-1.7	-2.5	-2.1	-0.5	-0.6	2.0	-1.8	0.4	1.6	0.7	-1.1	-2.3
Average weekly red wine intake	0.2	0.3	0.9	0.0	-0.0	-0.1	0.2	-0.6	0.8	-0.2	-0.9	-0.6	-0.2	-1.0	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.1	0.9	0.9	0.5	0.9	-0.9	0.9	0.3	-0.6	-1.0	0.2	0.4
Mood swings	0.3	0.6	3.7	-0.1	0.2	-0.4	-0.4	0.1	1.4	0.1	0.2	1.0	1.9	0.1	0.0
Loneliness, isolation	0.3	0.4	1.3	0.3	0.9	0.0	1.1	0.7	0.6	0.7	0.6	0.2	0.5	0.3	0.3
Long-standing illness, disability or infirmity	0.9	1.4	3.5	-1.8	-1.0	-1.9	0.0	-0.2	1.8	-1.6	0.5	0.6	0.0	-0.8	-1.6
Ever had bowel cancer screening	2.0	2.3	13.9	0.3	0.6	0.5	0.1	-0.3	-1.1	0.6	-0.5	-3.7	-3.3	-0.7	0.5
Diabetes diagnosed by doctor	0.9	1.5	4.8	-1.0	1.0	0.2	1.7	2.0	0.4	-0.5	2.2	1.5	0.6	0.8	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.0	-0.7	-0.5	-0.5	-0.1	-0.9	-0.4	-0.4	-1.1	-1.1	-1.4	-1.0	-0.2
Friendships satisfaction	0.3	0.3	1.1	-0.6	-0.7	-0.2	-0.7	0.1	-0.1	-0.7	0.1	0.3	-0.9	-0.2	-1.0
Qualifications: nursing, teaching	1.0	1.6	3.6	-1.1	-0.8	-1.2	1.5	-1.3	0.9	-0.3	-0.7	-1.9	-1.4	-1.9	-1.0
Commuting to job workplace: Walk	1.3	1.4	4.7	1.4	1.7	1.2	2.2	0.2	-0.5	1.6	0.2	-0.1	0.4	0.4	1.5
Eye problems/disorders: Cataract	0.8	0.9	3.4	-0.4	-0.8	-0.4	-0.3	-0.9	-0.2	-0.2	-1.4	-1.6	-1.9	-1.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	2.1	-0.0	-0.2	-0.8	0.9	-0.9	1.4	-0.5	-1.0	0.6	1.4	-0.4	-0.0
Medication for cholesterol	0.1	0.2	0.4	-0.5	0.5	-0.2	0.6	-0.5	0.3	0.6	-0.1	-0.1	0.3	-0.7	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	1.2	0.2	0.1	-0.4	-0.7	-1.1	-0.1	0.3	-0.9	-0.4	0.1	-0.2	0.7
Back pain experienced in last month	0.3	0.4	0.9	-0.6	-0.3	-0.5	-0.8	-0.6	0.6	-0.9	-0.8	-0.2	-0.5	-0.9	-0.3
Mineral and other dietary supplements	1.7	2.2	5.4	1.1	1.4	1.4	1.7	1.1	-2.3	1.5	0.9	-1.7	-1.2	1.5	1.5
Breast cancer (self-reported)	3.0	3.6	9.4	-1.9	-2.0	-2.4	-0.1	-1.3	3.1	-2.0	-0.8	-0.8	-0.4	-2.3	-2.8
Asthma (self-reported)	1.0	2.0	3.9	-1.8	-0.9	-1.8	-1.4	-1.7	0.3	-0.9	-0.5	-2.0	-1.6	-1.9	-0.6
Osteoporosis (self-reported)	0.9	1.1	2.5	-0.8	-1.6	-1.3	-1.2	-1.3	0.2	-1.2	-0.5	-0.5	-1.1	-0.9	-1.3
Osteoarthritis (self-reported)	0.3	0.5	1.5	-0.2	0.2	0.1	-0.3	1.0	0.5	-0.3	1.2	1.1	0.8	0.6	-0.4
Medication: Aspirin	0.9	1.2	3.0	-0.6	-0.8	-1.1	0.9	-1.6	1.2	-0.5	-1.7	-0.9	-0.3	-1.6	-0.5
Medication: Gliclazide	0.5	0.5	2.0	0.2	1.0	0.8	0.7	1.4	-0.4	0.0	0.9	0.2	0.0	0.9	0.5
Illnesses of father: None of the above (group 1)	2.3	2.9	6.4	2.5	1.6	2.0	1.3	1.0	-1.6	2.1	1.0	0.0	1.1	2.2	2.2
Smoking status: Current	2.2	3.5	8.2	-1.8	-2.2	-2.2	-1.3	-1.3	1.6	-2.9	-1.4	-1.3	-1.4	-2.0	-2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.7	3.6	7.6	1.2	2.5	2.4	2.0	2.8	-2.3	1.3	1.7	0.7	0.1	2.5	1.5
Whole body water mass	0.9	5.0	14.2	-0.6	-2.9	-2.5	-0.8	-3.8	2.6	-0.8	-3.2	-0.0	1.1	-2.9	-1.5
Leg predicted mass (right)	0.9	4.7	12.7	-0.6	-3.0	-2.6	-0.6	-3.6	2.6	-0.8	-3.2	0.0	1.1	-2.6	-1.5
Arm fat mass (left)	0.9	3.6	9.8	-1.7	-3.1	-2.6	-1.2	-1.5	2.3	-1.9	-0.3	1.5	0.8	-1.6	-2.5
Number of self-reported non-cancer illnesses	1.1	1.9	8.4	-1.4	-1.0	-1.9	-0.0	-1.1	2.9	-0.6	-0.0	0.4	0.5	-1.9	-1.6
Average weekly champagne plus white wine intake	6.8	9.3	15.6	3.4	3.5	3.9	2.3	2.6	-3.3	3.2	1.9	1.8	1.9	3.9	3.6
Miserableness	0.3	0.5	1.5	0.7	0.4	-0.2	0.0	-0.6	1.0	0.4	-1.2	-0.7	0.9	-0.5	0.5
Guilty feelings	0.5	0.7	2.0	-0.5	0.1	-0.6	1.4	-0.7	1.4	0.6	-1.4	0.3	1.0	-0.6	-0.2
Wears glasses or contact lenses	1.5	1.8	4.4	-2.1	-1.5	-1.6	-0.2	-0.2	1.5	-1.8	-0.5	-0.0	-0.6	-1.3	-2.1
Ever taken oral contraceptive pill	1.4	1.6	4.3	0.5	1.0	1.0	-0.5	1.6	-0.1	0.4	1.9	2.1	1.8	1.4	0.8
Hearing aid user	0.4	0.4	1.0	-0.6	-0.7	-0.5	0.5	-0.6	-0.1	-0.4	-0.7	-0.5	-1.0	-0.7	-0.8
Mother’s age at death	0.7	0.8	3.0	-0.8	-0.6	-0.6	0.5	-0.5	0.3	0.0	-1.1	-1.7	-1.6	-1.1	-0.5
Financial situation satisfaction	0.2	0.3	1.6	-0.2	-0.6	-0.1	-0.5	0.2	0.2	-1.3	0.2	0.8	0.5	0.0	-0.4
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	0.2	0.6	-0.0	0.8	0.9	1.2	0.0	1.5	1.2	1.2	0.3	0.2
Commuting to job workplace: Public transport	0.5	0.6	4.6	-0.1	0.7	0.5	2.1	0.6	1.0	0.4	-0.3	0.1	0.1	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.4	-0.2	0.1	-0.1	-0.3	0.4	-0.0	0.3	0.6	0.1	0.0	0.1	-0.1
Medication: Blood pressure	0.2	0.4	1.5	0.9	-0.2	0.4	-1.0	0.5	-0.4	0.4	0.6	0.1	0.3	1.2	0.1
Pain type(s) experienced in last month: Hip pain	1.0	1.3	2.6	-1.4	-0.8	-1.5	-0.5	-0.8	1.6	-1.1	-0.9	-0.7	-0.7	-1.6	-1.3
Supplements: Fish oil (including cod liver oil)	1.6	2.1	5.4	-1.1	-1.6	-1.5	-1.0	-1.2	2.3	-1.8	-0.7	1.1	0.8	-1.6	-1.7
High cholesterol (Self-reported)	1.0	1.8	3.2	1.4	1.4	1.5	1.8	1.3	-1.7	1.0	1.2	-0.3	-0.6	1.6	1.3
Medication: Bendroflumethiazide	0.3	0.5	1.3	1.0	0.0	0.6	-1.0	0.9	-0.1	0.4	0.8	0.6	0.6	1.1	0.2
Medication: Paracetamol	1.0	1.6	6.2	-1.0	-1.1	-1.7	-1.0	-1.2	2.5	-0.8	-0.5	0.5	0.6	-1.6	-1.1
Medication: Lisinopril	0.3	0.4	1.6	-0.7	-0.0	-0.3	0.1	-0.3	0.9	-0.2	-0.2	1.2	1.3	-0.4	-0.1
Medication: Atorvastatin	0.5	0.6	1.8	1.1	-0.1	0.5	0.6	0.5	-0.1	-0.3	1.3	1.2	1.0	1.0	0.3
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.6	-0.9	-0.9	-1.0	-0.5	0.8	-1.0	0.7	0.2	0.0	-0.4	-0.9
Alcohol drinker status: Never	1.6	1.9	4.2	0.5	1.6	1.6	0.6	1.9	-1.3	1.1	2.0	1.0	0.6	1.7	1.5
Ever smoked	0.3	0.6	2.0	1.1	-0.2	-0.2	-0.6	-1.2	0.5	0.2	-1.4	-0.6	0.9	-0.1	0.7
Basal metabolic rate	0.9	5.1	13.2	-0.8	-3.1	-2.7	-0.9	-3.6	2.7	-1.0	-2.9	0.3	1.1	-2.8	-1.8
Leg fat percentage (left)	1.0	3.7	7.8	-2.2	-2.8	-2.2	-1.1	-0.2	2.1	-2.1	1.3	2.4	0.8	-0.9	-2.8
Arm fat-free mass (left)	0.9	4.4	10.8	-0.9	-3.0	-2.5	-0.9	-3.3	2.4	-1.1	-2.7	0.4	0.7	-2.6	-1.9
Number of operations (self-reported)	1.8	2.6	5.0	-1.6	-1.6	-2.2	-0.2	-1.1	2.0	-1.0	-0.9	-2.1	-1.6	-2.0	-1.8
Average weekly beer plus cider intake	1.2	1.7	7.0	1.4	1.3	1.3	2.6	1.2	-0.3	1.9	0.9	0.2	0.7	1.1	0.9
Irritability	0.3	0.5	2.0	0.3	-0.0	-0.4	-1.1	0.1	1.0	0.0	0.8	1.1	1.4	0.4	0.2
Risk taking	0.3	0.4	1.4	-0.4	-0.2	-0.5	-0.6	-1.2	-0.3	-0.7	-0.3	-0.7	-0.7	-0.9	0.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.8	0.5	0.2	-0.2	1.7	-0.2	0.7	0.1	-0.3	-0.7	0.0	-0.1	0.2
Fractured/broken bones in last 5 years	0.6	0.7	2.0	-0.6	-1.4	-1.1	-1.1	-1.2	0.0	-1.1	0.1	-0.1	-0.7	-0.7	-0.8
Age started oral contraceptive pill	0.3	0.3	1.1	0.8	0.2	0.8	0.5	0.4	-0.1	0.8	-0.1	0.5	1.0	0.5	0.3
Diastolic blood pressure, automated reading	0.4	1.4	5.0	-0.5	-1.3	-0.5	-1.8	0.9	-0.3	-1.0	2.2	1.4	-0.4	0.8	-1.2
Ever depressed for a whole week	0.5	0.7	2.2	-0.2	1.0	0.6	1.5	1.5	-0.3	0.9	1.0	0.4	-0.2	0.6	0.1
Unable to work because of sickness or disability	5.6	7.3	16.6	-2.6	-2.9	-3.9	-1.0	-4.1	2.8	-2.6	-2.2	-1.1	-0.5	-3.8	-2.0
Commuting to job workplace: Cycle	1.2	1.4	3.4	1.4	1.7	1.4	0.6	0.4	-1.3	1.3	-0.8	-1.3	-0.3	0.7	1.9
Myopia	0.2	0.3	1.9	-0.0	0.0	0.3	0.7	-0.3	0.2	0.1	-1.4	-0.4	-0.1	-0.5	-0.2
Vascular/heart problems diagnosed by doctor	0.6	1.8	3.6	1.4	1.9	1.7	1.6	0.7	-1.7	1.2	-0.2	-0.0	0.4	1.2	1.9
Cholesterol lowering medication	0.5	0.8	2.6	0.0	0.0	0.5	1.2	0.9	-1.2	0.1	1.1	-0.7	-1.6	0.8	-0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.9	0.8	1.6	1.5	0.1	2.0	-1.2	0.5	1.9	-1.0	-0.9	1.2	1.2
Pain experienced in last month	0.6	1.0	5.0	0.7	0.7	1.3	0.1	0.7	-2.2	0.7	0.6	-0.7	-1.1	1.1	0.7
Supplements: Calcium	2.2	2.5	8.3	-1.1	-1.6	-1.4	-0.1	-2.3	1.3	-0.9	-2.9	-0.8	-0.7	-2.3	-1.2
Basal cell carcinoma (self-reported)	0.9	1.1	6.6	-0.2	-1.3	-0.9	-2.6	-1.3	0.5	-0.4	-0.5	-0.7	-0.1	-0.9	-0.2
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.6	-0.6	-0.6	-0.2	-0.8	0.4	0.1	-1.3	0.2	-0.5	-1.1	-0.3	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	2.0	-0.7	-0.4	-0.9	0.5	-0.8	1.4	-0.1	-0.2	-0.4	0.4	-1.1	-0.4
Heart disease (siblings)	2.3	2.9	7.9	-2.8	-1.4	-2.4	-1.6	-1.1	1.9	-1.3	0.0	-1.2	-1.1	-2.1	-1.8
Alcohol drinker status: Previous	0.5	0.5	1.8	0.3	0.4	-0.7	0.8	-0.8	1.3	0.8	0.3	-0.5	0.9	-0.9	0.5
Pack years of smoking	3.5	5.1	9.9	-2.3	-2.6	-2.4	-2.5	-2.5	1.2	-2.5	-1.4	-1.4	-2.2	-3.1	-2.2
Impedance of whole body	0.2	1.0	1.4	1.1	0.9	1.1	1.1	1.2	-1.0	1.2	0.9	-0.6	-0.4	1.2	0.7
Leg fat mass (left)	1.1	4.4	10.3	-2.0	-3.2	-2.7	-1.4	-1.4	2.6	-2.1	0.1	2.1	1.1	-1.5	-2.7
Arm predicted mass (left)	0.8	4.3	10.6	-0.8	-3.0	-2.5	-1.1	-3.2	2.4	-0.9	-2.6	0.6	1.0	-2.5	-1.8