Hub : Genes

FMO5

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1370 0.0370 2.2e-13 0.112 0.122 0.123 0.126 0.134 1.6e-13 1.3e-14 9.1e-15 4.8e-15 5.9e-16
2 GTEx Adrenal Gland 0.2844 0.0683 5.0e-08 0.191 NA 0.203 NA 0.214 2.1e-07 NA 8.1e-08 NA 3.4e-08
3 GTEx Artery Aorta 0.1090 0.0390 1.4e-05 0.101 NA 0.074 NA -0.004 3.4e-06 NA 6.8e-05 NA 6.7e-01
4 GTEx Artery Tibial 0.1017 0.0446 6.6e-04 -0.003 NA 0.017 NA 0.000 9.0e-01 NA 1.5e-02 NA 3.1e-01
5 GTEx Cells Transformed fibroblasts 0.0800 0.0350 2.0e-03 0.000 NA 0.001 NA 0.023 2.9e-01 NA 2.5e-01 NA 7.7e-03
6 GTEx Testis 0.2320 0.0640 4.1e-10 0.228 NA 0.242 NA 0.246 1.8e-10 NA 4.2e-11 NA 2.7e-11
7 GTEx Thyroid 0.1670 0.0490 5.9e-09 0.137 NA 0.150 NA 0.131 1.3e-10 NA 1.4e-11 NA 3.0e-10
8 METSIM Adipose 0.0583 0.0190 2.9e-07 0.038 0.046 0.025 0.043 0.035 2.1e-06 1.8e-07 8.7e-05 3.9e-07 4.8e-06
9 YFS Blood 0.1217 0.0314 9.5e-15 0.025 0.054 0.052 0.062 0.046 1.1e-08 3.4e-17 1.0e-16 1.3e-19 6.7e-15
10 TCGA Brain Lower Grade Glioma 0.0514 0.0275 8.7e-04 0.005 0.030 0.027 NA 0.019 7.0e-02 2.3e-04 4.2e-04 NA 2.4e-03
11 TCGA Pheochromocytoma and Paraganglioma 0.1520 0.0720 3.7e-05 0.103 0.135 0.124 NA 0.128 6.8e-05 5.1e-06 1.3e-05 NA 9.1e-06
12 TCGA Thyroid Carcinoma 0.0870 0.0370 4.1e-09 0.098 0.079 0.066 NA 0.083 8.5e-10 4.2e-08 5.6e-07 NA 1.7e-08

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.3 0.4 0.9 0.7 0.9 0.8 0.6 0.5 -1.0 0.6 0.3 -0.4 -0.3 0.6 0.9
Bipolar Disorder or Schizophrenia 2.7 6.5 11.6 2.5 3.4 3.4 2.2 2.9 -2.9 3.0 2.0 -0.7 -0.8 2.5 2.5
Depressed Affect (Nagel 2018) 0.2 0.5 1.5 0.3 0.7 0.0 0.1 1.0 0.8 0.1 0.8 0.8 1.2 0.8 0.4
Depression (Nagel 2018) 0.1 0.2 0.5 -0.5 -0.1 -0.7 -0.3 -0.3 0.7 -0.6 -0.0 -0.0 -0.4 -0.5 -0.4
Intelligence (Savage-Jansen 2018) 0.9 2.7 10.0 1.0 1.1 1.3 0.7 1.8 -1.2 1.5 3.2 2.1 1.2 2.0 1.2
Neuroticism (Nagel 2018) 0.2 0.5 1.4 0.1 1.2 0.2 0.3 1.1 0.0 0.5 1.1 0.6 0.6 1.0 0.6
Schizophrenia (2018) 3.6 7.6 13.7 2.7 3.6 3.7 2.3 3.3 -2.9 3.4 2.4 -0.6 -0.6 2.8 2.5
Schizophrenia vs Biploar Disorder 0.2 0.3 1.4 0.2 0.5 0.3 1.2 0.3 0.2 0.5 0.3 -0.6 -0.8 -0.3 -0.2
Worry (Nagel 2018) 0.2 0.5 1.4 -0.0 1.2 0.4 0.5 1.1 0.1 0.6 1.1 0.6 0.2 0.8 0.3
Alzheimer’s Disease (in mother) 0.9 1.0 2.6 0.1 -0.5 -0.7 0.6 -1.6 0.4 -0.3 -1.5 -1.5 -1.0 -1.4 -0.6
Alzheimer’s Disease (in father) 0.7 0.7 2.0 0.5 1.2 1.1 1.0 0.7 -1.4 0.5 0.2 -0.2 -0.6 0.8 0.8
Alzheimer’s Disease (including proxy) 0.5 0.7 1.6 0.7 0.9 0.7 1.2 -0.4 -0.8 0.7 -0.8 -1.3 -1.0 -0.2 0.6
Crohns Disease (2017) 0.5 1.0 4.5 0.8 0.2 0.3 2.1 -0.2 -0.8 1.2 -0.7 -1.6 -1.3 -0.0 0.3
Irritable Bowel Disease (IBD) 0.3 0.6 3.1 -0.7 -0.3 -0.6 0.9 -0.0 -0.3 -0.2 0.1 -1.3 -1.8 -0.6 -0.8
Ulcerative Colitis (UC) 0.3 0.6 1.6 -1.3 -0.2 -0.7 -0.3 0.7 -0.0 -1.1 1.3 0.0 -0.9 -0.2 -1.0
Major Depression (MDD) 0.6 0.7 3.5 0.1 -0.5 -0.3 -0.9 -0.4 -0.6 -0.3 0.5 -1.8 -1.9 -0.6 -0.1
Reaction Time 0.2 0.5 1.7 -0.4 -1.0 -0.3 0.1 -0.1 0.7 -1.2 -0.2 0.4 -0.3 -0.5 -1.3
Verbal and Numeric Reasoning (VNR) 0.4 0.9 2.9 1.0 -0.1 0.6 -0.3 0.2 -1.4 0.9 1.7 0.9 0.6 1.3 0.9
Breast Cancer 0.3 0.7 3.4 -1.0 -0.6 -0.2 0.2 -0.1 -1.3 -0.3 -0.5 -0.8 -1.9 -0.0 -0.6
Ovarian Cancer 3.2 4.3 8.5 2.6 2.3 2.9 2.3 2.5 -1.3 1.8 0.8 1.4 1.0 2.7 1.9
Prostate Cancer 0.5 0.7 2.6 0.2 -0.7 -0.8 0.4 -1.2 1.6 -0.6 -1.4 -0.3 0.5 -0.6 -0.7
Age at First Birth 1.0 1.4 3.7 1.0 1.5 1.2 0.3 1.1 -0.2 0.6 0.3 1.7 1.9 1.5 1.2
Bipolar Disorder (2011) 1.0 1.0 2.2 0.8 1.3 1.4 0.7 1.5 -1.2 0.6 0.5 -0.7 -0.4 1.1 0.9
Body Mass Index (BMI) (2010) 0.7 0.9 2.8 -0.7 -1.3 -1.1 -1.7 -0.9 0.6 -1.0 -0.1 -1.1 -0.5 -0.9 -0.7
Coronary Artery Disease (CAD) 0.6 0.7 2.5 0.2 0.4 1.0 -0.6 1.2 -1.6 0.1 1.0 -0.1 -1.2 1.0 0.4
Crohns Disease (2012) 0.5 0.8 3.1 0.2 -0.2 0.4 1.3 0.1 -1.2 0.3 -0.2 -1.5 -1.8 -0.1 -0.3
Mean Putamen Volume 0.6 0.7 1.8 0.2 -0.7 -0.5 0.1 -0.7 1.2 -1.3 -1.3 0.8 0.9 -0.5 -0.4
Fasting Glucose 0.3 0.4 1.8 -1.3 -0.2 -0.3 0.1 0.4 -0.0 -1.0 0.6 0.7 -0.4 -0.3 -0.9
HbA1C 0.5 0.5 1.7 0.7 0.4 0.3 0.7 -1.1 -0.0 1.3 -0.8 0.2 0.8 -0.2 0.9
HDL Cholesterol 0.3 0.4 1.2 0.3 0.9 0.8 0.7 0.6 -0.5 1.1 0.1 -0.6 -0.7 0.4 0.5
LDL Cholesterol 0.3 0.5 2.0 -0.2 -0.2 -0.3 0.6 0.4 1.4 -0.5 -0.5 0.9 1.4 0.2 -0.7
Lupus 1.6 2.5 10.8 0.7 2.3 1.3 0.9 0.6 -1.0 1.6 0.1 -3.3 -2.0 -0.0 1.7
Neuroticism (2016) 0.6 0.9 2.6 -0.4 -0.1 -1.1 -0.6 -1.1 1.4 0.3 -1.2 -1.6 -0.5 -1.2 -0.3
Primary Biliary Cirrhosis 0.8 1.1 2.0 1.3 1.2 1.2 1.4 1.3 -0.1 0.8 0.8 0.9 0.8 1.1 0.5
Rheumatoid Arthritis 0.5 0.7 4.4 -0.1 -0.3 0.2 -2.1 0.2 -1.3 0.4 1.2 -0.4 -0.7 0.4 0.4
Schizophrenia (2014) 1.9 4.2 9.4 1.8 3.1 2.6 1.8 2.5 -1.9 2.5 2.0 -0.6 -0.6 1.8 1.9
Triglycerides 0.4 0.6 2.1 0.8 0.3 -0.1 -0.2 -1.4 -0.3 0.7 -1.2 -0.3 0.7 -0.3 1.2
Type 2 Diabetes (T2D) (2012) 0.6 0.6 2.1 -1.2 0.0 -0.3 1.1 1.2 0.1 -0.0 1.5 0.6 -0.6 0.1 -0.8
Ulcerative Colitis 0.6 0.9 4.9 -0.6 0.4 0.4 -0.5 1.5 -0.7 0.0 2.2 -0.2 -1.2 0.4 -0.4
Blood Eosinophil Count 0.0 0.4 1.0 -0.0 0.0 -0.3 1.0 -0.8 0.2 0.1 -1.0 -0.9 -0.2 -0.8 0.2
Blood Platelet Count 0.7 8.6 23.5 3.4 2.5 3.5 0.3 2.5 -4.8 2.2 3.2 0.2 -0.4 4.4 3.1
Blood Red Count 0.1 1.2 2.7 -1.6 -1.4 -1.5 0.6 -0.6 1.5 -0.3 0.1 0.8 0.5 -1.4 -1.3
Blood White Count 0.2 1.6 4.4 -2.0 -1.2 -1.3 -0.4 -0.2 0.6 -2.1 -0.5 -0.3 -1.6 -1.1 -1.9
Heel T-Score 0.0 0.3 0.9 -0.5 -0.3 -0.5 -0.2 0.3 0.7 -0.5 0.4 0.9 0.8 0.1 -0.2
BMI 0.5 2.6 5.0 -1.7 -2.2 -2.1 -1.9 -0.7 1.8 -1.3 0.5 2.0 1.6 -0.7 -1.6
Height 0.7 12.7 42.5 0.5 -3.9 -3.6 0.8 -6.5 4.1 0.0 -6.0 -1.2 2.1 -4.4 -1.5
Waist Hip Ratio (WHR) 0.3 1.3 3.7 -0.3 0.7 1.1 1.1 1.9 -1.7 -0.2 0.9 -0.5 -1.9 1.0 0.0
Systolic Blood Pressure 0.5 2.4 10.4 0.9 0.9 1.4 -0.8 2.3 -1.2 0.6 3.2 1.2 0.1 2.1 0.6
Smoking Status 0.2 0.5 2.5 0.8 -0.1 0.1 -0.4 0.2 -0.0 -1.0 -0.1 -1.6 -1.2 0.0 0.0
Allergy or Eczema 0.3 0.7 2.2 0.7 1.5 0.2 1.1 0.1 0.7 0.6 0.0 -1.3 0.2 -0.6 1.2
Cardiovascular Disease 0.2 0.7 3.5 -0.7 -0.5 -0.6 0.5 0.8 0.6 0.4 1.9 1.0 0.3 0.5 -0.8
Hypothyroidism (self reported) 0.3 0.7 2.0 -0.9 -1.1 -0.7 -1.4 -0.7 -0.2 -1.0 -0.5 -0.2 -0.9 -0.8 -0.7
Respiratory disease 1.1 2.4 4.6 -2.1 -1.4 -2.1 -0.9 -1.3 1.2 -1.4 -0.7 -1.6 -1.5 -2.0 -1.4
Type 2 Diabetes (T2D) (2018) 1.6 3.1 10.6 -1.3 1.2 0.4 2.7 3.3 0.4 -0.3 3.1 1.8 0.4 1.4 -0.7
Lung FEV1/FVC ratio 1.0 5.0 13.4 1.1 1.5 2.1 2.4 3.4 -1.2 1.6 3.7 2.9 1.1 2.7 0.7
Lung FVC 0.2 0.9 3.3 -0.1 1.4 1.2 -0.2 1.2 -1.8 0.1 0.2 -0.5 -1.1 0.9 0.8
Neuroticism 0.1 0.3 1.5 0.2 0.6 -0.3 -0.1 0.0 0.9 0.6 0.2 0.6 1.2 0.2 0.4
Chronotype (morning person) 0.2 0.5 1.4 0.9 -0.2 0.1 -0.3 -1.2 -0.7 0.4 -1.1 0.4 0.8 0.2 1.0
Hair Pigment 0.0 1.2 2.7 -0.8 -1.4 -1.4 -0.4 -1.5 1.6 -0.8 -0.4 0.9 0.9 -1.1 -1.0
Tanning 0.2 2.0 5.4 -1.8 -1.7 -1.5 -0.3 -0.5 1.1 -2.3 -1.4 -0.5 -1.1 -1.2 -2.2
Hand grip strength (left) 0.2 0.4 2.4 0.2 -0.1 0.6 -0.5 0.6 -1.5 0.5 0.4 0.2 -1.0 0.7 0.2
Number of treatments/medications taken 0.8 1.4 4.2 -1.2 -1.2 -1.9 -0.8 -0.8 2.0 -1.4 0.4 0.2 0.3 -1.1 -1.1
Average weekly spirits intake 0.6 0.7 2.1 -1.2 -0.5 -0.5 0.1 0.6 0.3 -1.4 0.6 -0.6 -1.5 -0.4 -1.2
Sensitivity / hurt feelings 0.1 0.2 0.7 -0.3 0.6 -0.1 -0.2 -0.0 -0.6 0.9 -0.2 0.4 0.2 0.3 0.7
Frequency of depressed mood in last 2 weeks 1.2 1.6 4.0 -0.6 -0.6 -1.5 -1.6 -2.0 1.9 -0.7 -1.3 -0.7 0.5 -1.8 -0.2
Hearing difficulty/problems: Yes 0.3 0.5 3.7 0.1 0.6 0.1 1.9 0.5 0.3 1.0 0.8 0.1 0.1 0.2 0.3
Relative age of first facial hair 0.1 0.2 1.2 0.5 0.1 0.3 0.6 -0.2 -0.2 1.1 -0.4 0.1 0.6 -0.0 0.5
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 2.3 -0.9 -1.3 -1.5 -1.4 -0.9 1.0 -1.2 -0.2 -1.0 -1.4 -1.3 -1.1
Ever used hormone-replacement therapy (HRT) 0.9 1.1 3.3 0.5 -0.9 -0.9 -0.4 -1.6 1.6 -0.7 -1.8 -0.5 0.7 -1.1 -0.5
Ever had hysterectomy (womb removed) 0.3 0.3 0.7 0.6 -0.5 -0.5 -0.8 -0.8 0.8 -0.1 -0.3 -0.6 0.0 -0.6 -0.2
Systolic blood pressure, automated reading 0.4 1.2 6.7 -0.3 -0.2 0.2 -1.2 1.7 -0.3 -0.4 2.6 0.9 -0.3 1.0 -0.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.6 -0.1 1.0 0.7 -0.1 0.5 -1.0 0.1 -0.4 -1.3 -1.3 -0.1 0.6
Angina 2.3 3.1 5.8 -1.8 -2.1 -2.4 -1.4 -1.9 2.2 -2.0 -1.4 0.2 -0.2 -1.9 -1.9
Medication for hormone replacement therapy 0.9 1.0 2.6 1.6 1.4 1.4 0.3 0.2 -1.0 0.7 -1.1 -0.7 -0.3 0.5 1.4
Vitamin and mineral supplements 1.1 1.5 3.8 0.8 1.4 1.2 0.1 1.2 -1.4 1.2 1.5 0.6 0.7 1.9 1.5
Supplements: Zinc 1.7 1.8 5.2 -1.0 -0.7 -1.2 -1.5 -1.9 1.6 -0.5 -2.3 -0.3 0.3 -2.2 -0.5
Medication: Co-codamol 0.4 0.5 2.4 0.3 -0.0 -0.3 -0.4 -0.2 1.2 -0.3 0.2 1.1 1.5 -0.4 0.0
Medication: Metformin 1.1 1.5 5.3 -1.8 -0.9 -1.2 -1.1 0.3 1.2 -2.3 1.1 0.1 -0.7 -0.9 -1.4
Diabetes (father) 0.8 1.0 3.1 -0.6 0.8 0.8 1.5 1.8 -0.4 -0.1 1.7 -0.2 -1.2 0.5 -0.4
Diabetes (mother) 0.3 0.4 1.1 -0.6 -0.8 -0.7 -0.8 -0.3 0.3 -1.0 0.2 0.3 -0.3 -0.3 -0.9
Severe depression (siblings) 2.5 2.8 4.8 -1.7 -1.9 -2.2 -0.8 -1.9 1.3 -1.5 -1.2 -1.9 -1.4 -2.2 -1.5
Pack years adult smoking proportion 3.2 4.8 9.3 -2.3 -2.6 -2.3 -2.6 -2.4 1.2 -2.4 -1.3 -1.3 -2.0 -3.1 -2.1
Impedance of leg (right) 0.2 1.2 3.0 0.9 1.1 1.4 0.6 1.5 -1.1 0.9 1.7 0.6 0.1 1.4 0.6
Leg fat-free mass (left) 1.0 5.2 13.2 -0.8 -3.1 -2.8 -0.8 -3.6 2.9 -1.1 -3.0 0.3 1.3 -2.8 -1.7
Trunk fat percentage 0.9 3.5 9.2 -1.5 -3.0 -2.5 -0.6 -1.3 2.6 -1.7 0.0 1.8 1.2 -1.3 -2.4
Hand grip strength (right) 0.2 0.4 1.8 -0.5 -1.3 -0.4 -0.9 0.2 0.0 -0.4 0.1 1.3 0.2 0.2 -0.8
Townsend deprivation index at recruitment 0.3 0.5 2.0 -0.2 -0.5 -0.6 0.3 -0.6 1.4 0.0 -0.5 0.4 1.4 -0.7 -0.1
Current tobacco smoking 2.0 3.3 7.9 -1.6 -2.3 -2.1 -1.8 -1.3 1.7 -2.8 -1.4 -1.1 -1.0 -2.0 -2.1
Average weekly fortified wine intake 0.4 0.4 1.5 0.1 0.4 -0.0 0.3 -0.7 0.7 0.4 -1.1 0.7 1.2 -0.5 0.6
Maternal smoking around birth 0.8 1.1 3.7 -1.2 -1.2 -0.9 -0.3 -0.5 0.2 -1.4 -0.4 -0.9 -1.9 -1.0 -1.3
Fed-up feelings 0.6 1.0 4.0 -0.9 -1.0 -1.4 -0.6 -0.3 2.0 -1.3 0.2 0.5 0.7 -0.7 -1.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 3.2 -0.9 -1.3 -1.3 -1.2 -1.7 1.4 -1.2 -1.8 1.0 0.7 -1.1 -1.1
Relative age voice broke 0.1 0.1 0.3 0.6 -0.3 0.2 0.4 -0.5 -0.4 0.1 -0.5 -0.3 -0.2 -0.1 0.2
Taking other prescription medications 2.1 3.2 8.8 -2.0 -1.8 -3.0 -0.5 -1.4 2.8 -2.0 -0.0 -0.3 0.2 -1.9 -1.9
Age when periods started (menarche) 2.4 5.9 9.1 2.8 2.9 2.8 2.6 2.0 -2.9 2.6 1.8 -0.1 0.2 3.0 2.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.5 0.9 0.5 0.3 -0.1 0.2 -0.2 1.0 0.1 -1.2 -0.3 0.3 0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.4 -0.5 -0.7 -1.0 -0.8 -1.2 1.5 -0.3 -0.6 0.5 1.0 -1.2 -0.4
Tinnitus: Yes, but not now, but have in the past 0.1 0.2 0.8 -0.4 0.1 0.2 0.3 0.5 0.1 -0.6 0.3 0.9 0.2 0.0 -0.3
Qualifications: CSEs or equivalent 0.9 1.2 3.9 -0.9 -2.0 -1.2 -1.4 -0.8 -0.0 -1.6 -0.6 -0.4 -0.9 -0.6 -1.3
Serious illness, injury or assault to yourself 5.3 6.4 12.1 -2.9 -3.5 -3.3 -3.1 -2.3 2.0 -2.9 -1.0 -1.2 -1.3 -2.8 -2.4
High blood pressure 0.3 0.8 2.1 -0.7 -1.1 -0.9 -1.2 -0.1 1.4 -0.5 0.5 0.6 0.3 -0.5 -1.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 3.0 0.9 1.7 0.7 0.4 0.5 0.3 0.6 0.1 -0.8 0.5 -0.1 1.4
Multivitamins +/- minerals 0.7 0.9 2.1 -0.9 -0.7 -0.4 1.1 -0.1 0.7 -1.3 -1.4 0.1 -0.7 -1.1 -1.4
Stomach or abdominal pain in last month 0.4 0.5 1.3 -0.4 0.4 0.1 1.0 1.2 -0.2 -0.1 1.1 -0.5 -1.1 0.3 -0.2
Supplements: Glucosamine 0.3 0.4 2.1 -0.5 -0.0 -0.3 -0.4 0.4 0.4 0.4 1.0 1.4 0.7 0.2 -0.4
Diverticular disease/diverticulitis (self-reported) 0.5 0.6 2.3 0.5 0.3 0.7 -1.2 -0.1 -1.1 0.4 0.4 -1.1 -1.5 -0.2 0.5
Medication: Atenolol 0.3 0.4 1.8 1.0 0.5 0.5 -1.4 0.4 -0.0 0.2 0.2 -0.2 0.5 0.8 0.6
Medication: Levothyroxine sodium 0.6 1.0 3.1 0.8 0.3 1.1 -0.2 1.0 -1.8 1.0 1.4 0.4 -0.3 1.4 0.9
Sitting height 0.4 2.6 7.7 0.1 -2.1 -1.4 0.0 -2.7 0.4 0.1 -2.8 -2.3 -0.9 -1.8 -0.8
Chronic bronchitis/emphysema (father) 1.4 1.7 3.7 -1.2 -1.3 -1.4 -0.4 -1.2 0.7 -1.1 -1.9 -1.0 -1.5 -1.5 -1.5
High blood pressure (mother) 1.2 1.6 4.6 -1.8 -1.5 -1.1 -2.0 -0.4 0.5 -2.1 -0.3 1.4 0.4 -0.5 -1.3
Body mass index (BMI) 0.7 2.9 6.4 -1.9 -2.5 -2.1 -1.6 -0.7 1.8 -2.0 0.6 2.0 0.8 -0.9 -2.2
Impedance of leg (left) 0.3 1.7 3.9 0.9 1.2 1.5 0.8 1.9 -1.3 1.1 2.0 0.8 0.1 1.8 0.7
Leg predicted mass (left) 0.9 5.0 13.0 -0.7 -3.1 -2.7 -0.7 -3.6 2.8 -1.0 -3.0 0.2 1.2 -2.7 -1.6
Trunk fat mass 1.2 5.3 13.0 -1.7 -3.6 -3.1 -0.9 -2.3 3.2 -1.8 -0.8 1.6 1.4 -2.2 -2.7
Waist circumference 1.0 3.6 8.9 -2.1 -3.0 -2.5 -0.8 -1.4 2.1 -2.0 -0.5 1.4 0.4 -1.7 -2.6
Number of incorrect matches in round 0.4 0.6 1.8 -0.1 -0.7 -0.1 -1.3 -0.1 1.1 -1.1 -1.3 -0.1 0.1 -0.7 -0.6
Past tobacco smoking 0.7 1.3 3.9 -2.0 -1.3 -1.1 -1.6 -0.1 0.3 -1.4 0.3 0.5 -0.6 -0.9 -1.6
Alcohol usually taken with meals 0.2 0.3 1.3 1.1 0.8 0.6 0.6 -0.0 -0.0 0.3 0.0 -0.3 0.5 0.1 0.7
Nervous feelings 0.1 0.2 1.1 0.0 1.0 0.0 0.2 0.5 0.4 0.4 -0.2 0.2 0.6 0.5 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 1.3 1.1 -0.0 -0.1 -1.1 -1.0 -0.0 0.4 -0.7 -0.3 0.3 -0.0 0.7
Hearing difficulty/problems with background noise 0.1 0.2 0.7 0.0 0.3 -0.1 0.9 -0.1 0.7 0.1 -0.1 0.5 0.7 -0.1 0.2
Hair/balding pattern: Pattern 2 0.3 0.4 1.1 1.0 0.2 0.1 -0.7 -0.6 -0.4 0.8 0.4 -0.2 0.6 0.4 1.0
Had menopause 0.8 1.0 2.6 1.5 0.6 0.9 1.3 0.6 -0.9 1.6 0.4 -1.2 -0.6 0.9 0.7
Had other major operations 1.9 2.3 4.3 -1.6 -1.5 -1.8 -0.4 -0.6 1.5 -1.6 -0.9 -1.4 -1.6 -2.0 -2.1
Forced vital capacity (FVC) 0.2 0.6 1.6 1.3 0.6 0.9 0.2 -0.3 -0.9 0.8 -1.2 -0.9 -0.1 0.3 1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.5 0.1 -0.3 -0.5 -0.6 -1.2 0.9 -0.2 -0.5 0.8 1.2 -0.7 0.3
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 1.4 -0.6 -0.4 -0.3 -0.2 -0.5 -0.2 -0.9 -0.8 -0.5 -1.2 -0.7 -0.4
Qualifications: None of the above 0.3 0.7 2.3 -1.5 -0.5 -1.1 0.0 0.5 1.0 -1.0 0.7 0.8 0.3 -0.1 -1.1
Financial difficulties in last 2 years 0.2 0.3 1.0 0.9 0.3 0.5 -0.2 0.3 0.1 -0.0 -0.1 0.9 1.0 0.2 0.7
Mouth/teeth dental problems 0.4 0.6 3.4 0.3 0.1 1.0 0.7 0.6 -1.0 0.0 -0.6 -0.9 -1.8 -0.0 -0.5
Heart attack 0.5 0.6 2.0 -0.5 -0.8 -0.4 -1.2 0.3 0.1 -1.4 0.1 -0.7 -1.3 -0.3 -0.7
Allergy 0.4 0.8 3.2 0.8 -0.4 0.8 0.0 0.7 -1.0 0.2 0.4 1.8 0.6 1.7 -0.1
Pain all over the body in last month 1.1 1.2 3.1 -1.4 -1.5 -1.8 0.1 -0.8 1.2 -0.8 0.6 -0.6 -0.5 -1.1 -1.4
Diabetes (self-reported) 1.1 1.7 5.0 -1.7 0.5 -0.1 1.7 2.0 0.5 -0.9 2.2 1.8 0.1 0.4 -1.0
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 2.3 0.2 0.9 0.2 1.5 0.3 0.4 0.3 -0.3 -0.1 0.2 -0.2 0.3
Medication: Ramipril 0.3 0.4 2.1 0.8 0.2 0.2 -0.7 -0.0 0.9 -0.3 -0.2 0.5 1.5 0.1 0.3
Medication: Simvastatin 0.6 0.9 3.1 0.1 1.6 0.9 1.8 1.4 -0.4 0.6 0.5 -0.1 -0.4 0.8 0.7
Fluid intelligence score 0.8 1.7 3.3 0.9 1.0 1.2 1.1 0.8 -1.6 1.5 1.8 1.6 1.0 1.4 1.4
Illnesses of siblings 1.1 1.6 4.5 2.1 1.2 1.3 0.7 -0.9 -1.1 1.5 -1.3 -0.4 0.8 0.4 2.0
Neuroticism score 0.1 0.3 1.2 -0.1 0.5 -0.5 0.1 -0.0 1.0 0.4 0.1 0.4 1.1 0.1 0.2
Weight 1.0 5.0 12.7 -1.6 -3.6 -3.0 -1.2 -2.7 2.9 -1.7 -1.5 1.1 1.2 -2.3 -2.5
Impedance of arm (right) 0.1 0.6 1.7 0.5 0.5 0.6 1.2 0.8 -1.0 0.3 0.4 -1.3 -0.8 0.7 0.4
Arm fat percentage (right) 0.8 3.2 7.4 -2.2 -2.7 -2.3 -0.7 -0.5 2.0 -2.3 0.6 1.7 0.5 -1.1 -2.6
Trunk fat-free mass 0.7 4.1 13.2 -0.4 -2.5 -2.3 -0.8 -3.6 2.2 -0.5 -3.0 -0.5 0.7 -2.7 -1.2
Hip circumference 1.3 5.6 13.3 -1.6 -3.6 -3.3 -1.4 -3.0 2.9 -1.8 -1.6 1.0 1.1 -2.5 -2.6
Time employed in main current job 1.3 1.5 2.6 1.2 1.5 1.1 1.5 1.4 1.0 1.6 0.5 0.6 1.6 0.9 0.9
Alcohol intake versus 10 years previously 2.3 3.5 9.2 -0.9 -2.3 -2.2 -0.4 -1.9 3.0 -2.0 -1.7 1.3 1.6 -1.8 -1.8
Father’s age at death 0.3 0.5 1.4 1.2 0.4 0.6 1.1 0.3 -0.6 0.9 0.4 -0.3 0.1 0.8 0.5
Worrier / anxious feelings 0.1 0.2 1.0 0.0 0.5 0.1 0.1 0.5 0.5 0.1 1.0 -0.1 -0.3 0.2 -0.3
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.6 -0.2 0.8 0.0 -0.0 0.3 -0.6 0.1 0.7 0.3 0.0 0.5 0.7
Falls in the last year 3.0 4.1 9.4 -2.7 -2.2 -3.1 -2.5 -2.4 1.3 -2.1 -0.6 -1.3 -0.9 -2.2 -1.4
Hair/balding pattern: Pattern 3 0.5 0.8 1.8 1.1 1.4 1.0 0.6 0.4 0.0 0.8 -0.5 1.2 1.0 0.7 0.9
Number of live births 1.6 2.2 8.2 -0.5 -0.2 1.1 -0.7 2.6 -1.2 -0.2 2.9 2.1 -0.4 1.8 -0.7
Forced expiratory volume in 1-second (FEV1) 0.3 1.0 1.6 1.1 1.0 1.3 1.0 0.9 -1.1 1.1 0.3 0.3 0.4 1.2 1.1
Pulse rate 1.4 2.4 7.0 0.5 1.7 1.5 1.0 2.6 -1.3 0.7 2.7 0.8 0.3 2.2 1.0
Happiness 0.3 0.3 1.0 -0.1 -0.2 -0.1 0.1 0.4 1.0 -0.7 0.8 0.9 0.4 0.0 -0.8
Noisy workplace 1.6 1.9 8.1 0.1 0.9 1.0 0.1 2.8 0.4 -0.2 2.7 1.8 0.8 1.4 -0.1
Qualifications: A levels/AS levels or equivalent 0.1 0.2 1.1 -0.0 0.3 0.4 0.1 -0.2 -0.4 0.2 -1.0 -0.7 -0.6 -0.6 0.0
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 3.7 -0.6 0.6 0.6 0.2 1.7 -1.1 -0.4 1.9 1.0 -0.5 1.2 -0.1
Mouth/teeth dental problems: Dentures 1.5 2.6 6.5 -2.2 -1.8 -2.5 -1.6 -1.3 1.7 -1.9 0.2 -0.1 -0.2 -1.9 -1.5
Asthma 1.1 2.1 4.7 -2.0 -0.9 -1.7 -1.1 -1.5 0.1 -0.9 -0.2 -2.2 -2.1 -1.9 -0.7
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 4.1 -0.7 -1.4 -1.7 -1.5 -2.0 1.1 -1.0 -1.8 -0.9 -0.5 -1.7 -0.8
Medication: Cholesterol lowering 0.2 0.3 2.1 -0.5 0.5 -0.3 1.5 0.3 0.8 -0.3 0.0 -0.0 -0.2 -0.4 -0.1
Depression (self-reported) 0.5 0.6 2.8 -0.9 -0.2 -0.9 0.1 -0.1 1.7 -0.7 -0.3 0.0 0.5 -1.1 -0.6
Medication: Lansoprazole 2.3 2.6 6.6 -2.4 -2.0 -2.1 -1.1 0.0 1.9 -1.9 1.0 0.9 -0.2 -1.1 -2.6
Prospective memory result 0.4 0.5 1.1 0.9 0.3 0.5 -0.8 0.4 -0.5 0.6 -0.0 0.6 1.1 1.1 0.7
Lung cancer (father) 1.5 1.8 3.9 -1.5 -2.0 -2.0 -0.8 -1.0 1.4 -1.6 -0.1 1.0 0.8 -0.7 -1.8
Illnesses of mother 2.2 2.7 5.1 2.1 1.6 1.8 2.2 1.3 -1.8 2.3 0.4 -0.4 0.1 1.8 1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.8 3.9 1.3 1.6 1.6 1.8 1.0 -1.5 2.0 0.0 0.4 0.6 1.3 1.6
Pulse wave Arterial Stiffness index 0.3 0.4 2.4 -0.6 -0.4 -0.4 -1.6 -0.1 -1.0 -0.1 0.5 0.1 -0.5 0.2 0.1
Impedance of arm (left) 0.2 0.9 2.3 1.2 0.8 0.8 1.5 0.4 -0.9 1.1 -0.2 -1.5 -0.6 0.6 0.9
Arm fat mass (right) 0.9 3.6 9.3 -1.8 -3.0 -2.6 -1.1 -1.4 2.3 -1.9 -0.1 1.6 0.8 -1.6 -2.5
Trunk predicted mass 0.7 4.0 13.0 -0.3 -2.4 -2.2 -0.7 -3.6 2.1 -0.4 -3.1 -0.5 0.8 -2.7 -1.1
Standing height 0.6 5.6 19.6 0.7 -2.5 -2.2 0.4 -4.4 2.3 0.6 -4.3 -1.7 0.9 -2.8 -0.6
Length of working week for main job 1.4 1.5 3.4 1.4 1.0 1.1 1.0 1.0 -0.9 1.1 0.8 1.2 1.7 1.9 1.3
Exposure to tobacco smoke at home 0.3 0.3 1.1 0.9 -0.0 0.3 0.1 -0.4 0.4 -0.4 -1.1 0.6 0.8 -0.1 0.1
Breastfed as a baby 0.4 0.6 4.1 0.4 0.2 0.2 2.0 0.7 0.0 0.6 1.1 -0.1 0.2 0.4 -0.1
Tense / ‘highly strung’ 0.1 0.2 0.9 0.1 1.0 -0.0 -0.5 -0.1 0.5 0.3 -0.2 -0.4 0.3 -0.2 0.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.0 -1.4 -0.4 -1.2 -1.2 -0.0 1.2 -0.2 0.8 -0.9 -1.0 -1.0 -1.0
Hair/balding pattern: Pattern 4 1.3 3.2 8.7 -3.0 -1.6 -1.7 0.1 0.3 1.8 -2.2 -0.2 -1.0 -1.8 -1.9 -2.9
Birth weight of first child 0.6 1.0 3.5 -0.1 -0.5 -1.2 0.2 -1.9 0.6 0.6 -1.1 -1.8 -0.2 -1.3 0.1
Peak expiratory flow (PEF) 0.1 0.3 1.2 0.1 0.4 0.6 0.9 0.4 -1.1 0.5 0.5 -0.1 -0.7 0.5 0.4
Pulse wave reflection index 2.4 2.9 5.9 -2.4 -2.0 -2.0 -1.9 -1.6 0.4 -1.7 -1.4 -0.6 -1.6 -2.1 -1.8
Ever highly irritable/argumentative for 2 days 0.5 0.6 2.3 -0.2 -0.3 -0.7 -0.7 -0.7 1.0 -0.4 -0.0 1.5 1.5 -0.2 -0.2
Loud music exposure frequency 1.0 1.1 4.9 1.0 0.3 0.4 1.4 -0.5 0.5 -0.0 -1.1 1.8 2.2 0.1 0.6
Qualifications: O levels/GCSEs or equivalent 0.6 0.9 3.7 0.8 0.7 0.9 1.8 0.6 -0.4 1.9 0.8 0.7 0.5 0.5 0.6
Mouth/teeth dental problems: Bleeding gums 1.8 2.4 7.3 1.9 1.1 1.1 -0.0 0.9 0.0 1.8 1.3 1.9 2.7 1.8 1.6
Blood clot in the leg (DVT) 0.4 0.5 2.2 -0.6 -0.4 -0.9 0.3 -0.8 1.5 0.0 -0.1 -0.4 0.7 -1.0 -0.3
Medication: Paracetamol 1.1 1.8 8.2 -1.0 -1.0 -1.6 -0.9 -0.6 2.9 -1.1 -0.1 0.9 1.2 -1.3 -1.3
Headache pain in last month 0.1 0.2 0.8 -0.3 -0.1 -0.2 -0.5 0.2 0.8 -0.2 -0.1 0.9 0.9 0.0 -0.2
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.7 1.3 0.4 0.9 -0.2 -0.5 -1.3 1.0 -0.3 -0.0 0.3 0.7 1.1
Glaucoma (self-reported) 0.1 0.1 0.4 -0.6 -0.0 -0.6 -0.0 -0.1 0.3 0.6 0.3 -0.2 0.0 -0.2 -0.0
Gout (self-reported) 0.6 0.8 3.2 0.4 0.1 0.2 0.8 0.3 1.2 1.3 0.4 1.4 1.8 0.3 0.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 1.9 -0.9 -1.4 -0.5 -1.4 0.1 -0.3 -1.2 0.6 0.3 -0.9 -0.1 -1.0
Medication: Amlodipine 0.1 0.1 0.5 -0.2 0.2 -0.2 0.7 0.3 0.2 -0.6 -0.4 0.2 0.4 0.3 -0.0
Medication: Ventolin 100micrograms inhaler 1.4 1.8 4.6 -1.0 -1.2 -1.5 -1.0 -2.0 0.1 -0.7 -1.2 -2.1 -1.6 -1.6 -0.4
Birth weight 0.2 0.4 1.1 0.4 -0.2 -0.7 0.6 -1.0 0.8 1.0 -0.4 -0.2 1.0 -0.3 0.3
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.7 0.4 0.3 0.2 -0.8 -0.5 -0.5 0.4 -0.7 -0.8 -0.6 -0.0 0.3
High blood pressure (siblings) 1.1 1.5 4.0 -2.0 -1.0 -0.9 -0.8 1.2 0.4 -1.4 1.3 -0.4 -1.6 -0.4 -1.9
Forced vital capacity (FVC), Best measure 0.3 1.0 2.4 1.4 1.0 1.1 0.8 -0.2 -1.1 1.6 -1.2 -0.5 0.3 0.5 1.4
Body fat percentage 0.9 3.5 8.7 -1.9 -3.0 -2.4 -0.7 -0.8 2.3 -1.9 0.5 2.0 0.9 -1.2 -2.6
Leg fat percentage (right) 1.0 3.6 7.2 -2.1 -2.7 -2.1 -1.2 -0.3 2.1 -2.0 1.3 2.5 0.9 -0.9 -2.7
Arm fat-free mass (right) 0.9 4.5 12.7 -0.5 -2.7 -2.4 -0.9 -3.6 2.7 -0.4 -2.8 0.5 1.4 -2.7 -1.4
Exposure to tobacco smoke outside home 0.1 0.1 0.4 0.6 -0.4 -0.0 0.4 -0.1 0.0 0.0 0.5 0.3 0.1 0.3 0.0
Comparative body size at age 10 0.4 1.1 4.5 0.3 -0.4 -0.4 -2.1 -1.8 0.3 -0.3 -1.9 -0.6 -0.1 -1.2 0.2
Number of full brothers 0.1 0.2 0.6 -0.3 -0.8 0.0 -0.3 0.1 -0.6 0.2 -0.0 0.8 0.0 0.5 -0.3
Worry too long after embarrassment 0.1 0.2 0.6 0.0 0.6 0.2 0.1 0.2 -0.6 0.4 0.2 -0.7 -0.8 0.3 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 1.5 0.1 0.2 -0.4 0.5 -0.3 1.2 -0.0 -0.1 0.3 0.6 -0.4 -0.0
Wheeze or whistling in the chest in last year 2.2 3.9 7.9 -1.9 -1.9 -2.8 -2.2 -2.4 2.4 -1.8 -1.2 -1.1 -0.4 -2.7 -1.6
Number of children fathered 1.5 1.7 7.8 -1.2 -0.8 -0.5 -1.7 -0.3 -1.0 -0.1 0.3 -2.0 -2.8 -0.9 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 3.1 3.6 8.4 2.0 2.9 2.3 2.7 1.3 -1.4 2.4 0.4 -1.2 -0.2 1.2 2.4
Age at first live birth 0.5 0.8 2.9 0.6 1.6 1.0 1.7 0.6 -0.3 1.2 -0.7 -0.3 0.1 0.4 0.8
Pulse wave peak to peak time 0.5 0.5 2.8 0.9 0.2 0.4 1.7 -0.3 1.1 0.3 -0.9 -0.2 0.6 -0.3 -0.0
Health satisfaction 0.3 0.3 1.1 -0.2 -0.3 -0.3 -0.9 0.7 0.3 -0.7 1.1 -0.1 -0.6 0.5 -0.6
Shortness of breath walking on level ground 2.4 2.8 6.0 -1.6 -1.5 -2.0 -1.1 -2.2 1.8 -1.5 -2.5 -0.7 -0.3 -2.2 -1.4
Qualifications: College or University degree 1.4 4.5 8.8 2.2 2.3 2.5 2.1 0.6 -3.0 2.9 -0.3 -2.4 -1.4 1.2 2.6
Eye problems/disorders: None of the above 0.9 1.1 4.0 0.8 0.7 0.5 0.8 0.5 -0.1 0.5 0.9 1.8 2.0 1.2 0.8
Mouth/teeth dental problems: Loose teeth 1.0 1.2 2.9 1.0 1.4 0.9 0.4 0.6 -0.9 1.1 1.5 0.5 0.9 1.3 1.7
Emphysema/chronic bronchitis 1.8 2.0 4.3 -1.2 -0.9 -1.4 -1.2 -1.4 1.1 -1.5 -1.7 -2.0 -1.2 -2.1 -0.7
Medication for pain relief, constipation, heartburn 1.4 2.3 7.5 1.3 1.5 2.0 1.0 1.4 -2.7 1.6 0.9 0.2 -0.2 1.9 1.5
Neck or shoulder pain in last month 0.2 0.3 0.8 0.2 0.7 -0.4 0.4 -0.4 0.9 0.3 -0.7 -0.3 0.3 -0.7 0.6
Medication: Blood pressure 1.3 2.3 4.8 -1.9 -1.7 -1.8 -1.9 -0.2 2.1 -2.2 -0.0 0.5 0.1 -1.2 -1.9
Angina (self-reported) 2.0 2.6 4.8 -1.5 -2.0 -2.2 -1.4 -1.8 1.8 -2.0 -1.5 0.3 -0.1 -1.6 -1.6
Migraine (self-reported) 1.4 1.7 5.5 1.1 1.0 1.2 1.2 1.4 0.2 0.4 1.9 2.3 1.7 1.3 0.5
Medication: Ibuprofen 2.4 2.8 6.3 -1.0 -1.8 -2.2 -1.7 -2.5 1.3 -1.5 -1.8 -1.5 -0.9 -2.0 -1.1
Medication: Allopurinol 0.3 0.4 1.5 -0.1 -0.7 -0.3 -0.6 0.0 1.2 0.1 0.4 0.8 1.1 -0.3 -0.6
Medication: Omeprazole 0.5 0.5 2.1 0.2 0.9 0.8 -0.2 1.5 0.0 -0.0 1.4 0.3 0.3 0.7 0.4
Medication: Seretide 50 evohaler 2.0 2.3 5.6 -1.4 -1.8 -1.9 -1.6 -2.4 0.4 -0.6 -1.6 -1.4 -1.0 -2.0 -0.8
Mean time to correctly identify matches 0.7 1.4 4.1 -1.1 -1.4 -1.1 0.3 -0.5 1.7 -1.6 -0.9 0.2 -0.4 -1.3 -2.0
Heart disease (mother) 0.5 0.6 3.1 -0.5 0.0 -0.6 -0.5 0.2 0.4 -0.4 1.1 -1.8 -1.4 -0.4 -0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 1.0 1.8 -0.9 -1.3 -0.9 -1.3 -0.0 0.6 -0.9 1.0 -0.8 -1.4 -0.7 -1.2
Whole body fat mass 1.2 4.8 12.2 -1.8 -3.5 -3.0 -1.1 -2.2 2.8 -2.0 -0.8 1.5 1.0 -2.1 -2.7
Leg fat mass (right) 1.1 4.3 10.0 -2.0 -3.2 -2.7 -1.4 -1.4 2.6 -2.0 0.2 2.2 1.2 -1.6 -2.6
Arm predicted mass (right) 0.9 4.7 13.6 -0.4 -2.8 -2.4 -0.9 -3.7 2.7 -0.4 -3.0 0.5 1.3 -2.8 -1.4
Pulse rate, automated reading 1.1 3.7 12.3 0.6 1.7 1.7 1.8 2.9 -2.2 0.7 3.5 -0.9 -1.9 2.2 0.8
Alcohol intake frequency. 1.6 3.7 10.6 -2.1 -1.9 -2.7 -1.8 -1.7 3.2 -1.2 -0.1 1.3 1.7 -2.1 -1.6
Comparative height size at age 10 2.7 14.8 35.3 -1.7 -4.5 -4.4 -2.3 -5.9 4.7 -1.7 -5.7 -1.3 0.9 -5.2 -2.7
Number of full sisters 0.6 0.8 2.4 -1.5 -0.8 -0.8 0.0 0.5 0.1 -1.0 1.1 0.5 -1.1 -0.3 -1.3
Suffer from ‘nerves’ 0.2 0.3 0.7 -0.6 0.8 -0.1 0.4 0.6 0.2 0.5 0.5 -0.5 -0.7 -0.1 -0.1
Overall health rating 0.3 0.6 3.0 -0.9 -0.5 -0.8 -0.0 0.5 0.8 -0.6 1.7 0.7 -0.1 0.0 -0.8
Chest pain or discomfort 0.2 0.2 0.6 0.1 -0.5 -0.7 -0.7 -0.5 0.7 -0.2 0.6 -0.2 -0.0 -0.5 0.0
Had major operations 0.7 0.8 1.8 -0.8 -1.3 -1.3 -0.0 -0.3 1.3 -1.3 0.3 0.4 0.1 -0.5 -1.3
Age at last live birth 0.3 0.4 1.8 -0.4 0.6 0.2 1.3 0.2 0.1 0.5 -0.9 -0.8 -0.8 -0.5 -0.0
Family relationship satisfaction 0.1 0.1 0.6 0.1 -0.0 -0.2 -0.2 -0.8 0.5 -0.2 0.2 0.1 0.3 -0.5 0.1
Leg pain on walking 0.8 1.1 2.9 -1.1 -0.9 -1.6 -0.5 -0.6 1.7 -1.3 -0.7 0.4 0.4 -0.9 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 7.2 -0.2 -1.3 -1.1 -2.7 -1.3 0.9 -0.8 -0.9 1.0 1.4 -0.7 -0.3
Commuting to job workplace: Car/motor vehicle 1.9 2.2 4.5 -2.0 -1.9 -1.8 -2.1 -0.9 1.0 -2.0 -0.2 0.4 -0.4 -1.2 -1.9
Illness, injury, bereavement, stress in last 2 years 0.0 0.0 0.3 0.1 0.1 0.0 -0.0 0.2 0.1 0.3 -0.1 -0.6 0.0 0.1 -0.1
Medication: Aspirin 0.6 0.7 2.3 0.1 -0.4 -0.5 1.3 -1.3 0.8 -0.3 -1.5 -0.8 -0.2 -1.2 -0.1
Supplements: Vitamin C 0.7 0.8 1.9 -1.1 -1.1 -0.8 -1.0 -0.1 0.1 -0.7 1.4 -0.2 -1.2 -0.7 -1.1
Knee pain experienced in last month 1.8 2.8 4.4 -2.1 -2.1 -1.9 -1.5 -1.2 2.0 -1.7 -1.3 1.3 0.4 -1.5 -2.1
Hypertension (Self-reported) 0.4 1.2 3.8 -1.1 -1.3 -1.3 -0.9 -0.1 1.9 -0.7 0.5 0.7 0.4 -0.7 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.7 8.8 1.0 1.6 1.7 0.6 2.7 -1.2 1.0 3.0 0.8 0.2 2.3 0.9
Illnesses of father: Heart disease 1.8 2.5 5.5 -1.9 -1.2 -1.5 -1.9 -1.1 1.4 -1.9 -0.9 -1.3 -1.4 -2.4 -1.6
Illnesses of siblings: Diabetes 1.2 1.4 3.2 -1.5 -0.3 -0.6 0.2 1.6 1.2 -1.5 1.8 1.5 0.5 0.3 -1.5
Smoking status: Previous 1.5 2.2 5.2 2.3 1.9 1.7 1.7 0.7 -0.9 2.1 0.4 -0.2 0.6 1.4 2.0
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.0 1.0 -0.8 -0.5 -0.6 -1.7 0.2 0.7 -1.4 -1.6 -0.3 -0.8 0.3
Whole body fat-free mass 1.0 5.5 15.4 -0.7 -3.0 -2.7 -0.9 -3.9 2.7 -0.9 -3.4 -0.1 1.1 -3.0 -1.6
Leg fat-free mass (right) 0.9 4.8 12.8 -0.7 -3.0 -2.6 -0.7 -3.6 2.6 -0.8 -3.2 0.0 1.1 -2.6 -1.5
Arm fat percentage (left) 0.6 2.5 6.1 -1.7 -2.5 -2.1 -0.5 -0.6 2.0 -1.8 0.4 1.6 0.7 -1.1 -2.3
Average weekly red wine intake 0.2 0.3 0.9 0.0 -0.0 -0.1 0.2 -0.6 0.8 -0.2 -0.9 -0.6 -0.2 -1.0 -0.4
Handedness (chirality/laterality): Left-handed 0.4 0.5 0.9 0.1 0.9 0.9 0.5 0.9 -0.9 0.9 0.3 -0.6 -1.0 0.2 0.4
Mood swings 0.3 0.6 3.7 -0.1 0.2 -0.4 -0.4 0.1 1.4 0.1 0.2 1.0 1.9 0.1 0.0
Loneliness, isolation 0.3 0.4 1.3 0.3 0.9 0.0 1.1 0.7 0.6 0.7 0.6 0.2 0.5 0.3 0.3
Long-standing illness, disability or infirmity 0.9 1.4 3.5 -1.8 -1.0 -1.9 0.0 -0.2 1.8 -1.6 0.5 0.6 0.0 -0.8 -1.6
Ever had bowel cancer screening 2.0 2.3 13.9 0.3 0.6 0.5 0.1 -0.3 -1.1 0.6 -0.5 -3.7 -3.3 -0.7 0.5
Diabetes diagnosed by doctor 0.9 1.5 4.8 -1.0 1.0 0.2 1.7 2.0 0.4 -0.5 2.2 1.5 0.6 0.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.0 -0.7 -0.5 -0.5 -0.1 -0.9 -0.4 -0.4 -1.1 -1.1 -1.4 -1.0 -0.2
Friendships satisfaction 0.3 0.3 1.1 -0.6 -0.7 -0.2 -0.7 0.1 -0.1 -0.7 0.1 0.3 -0.9 -0.2 -1.0
Qualifications: nursing, teaching 1.0 1.6 3.6 -1.1 -0.8 -1.2 1.5 -1.3 0.9 -0.3 -0.7 -1.9 -1.4 -1.9 -1.0
Commuting to job workplace: Walk 1.3 1.4 4.7 1.4 1.7 1.2 2.2 0.2 -0.5 1.6 0.2 -0.1 0.4 0.4 1.5
Eye problems/disorders: Cataract 0.8 0.9 3.4 -0.4 -0.8 -0.4 -0.3 -0.9 -0.2 -0.2 -1.4 -1.6 -1.9 -1.0 -0.7
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 2.1 -0.0 -0.2 -0.8 0.9 -0.9 1.4 -0.5 -1.0 0.6 1.4 -0.4 -0.0
Medication for cholesterol 0.1 0.2 0.4 -0.5 0.5 -0.2 0.6 -0.5 0.3 0.6 -0.1 -0.1 0.3 -0.7 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 1.2 0.2 0.1 -0.4 -0.7 -1.1 -0.1 0.3 -0.9 -0.4 0.1 -0.2 0.7
Back pain experienced in last month 0.3 0.4 0.9 -0.6 -0.3 -0.5 -0.8 -0.6 0.6 -0.9 -0.8 -0.2 -0.5 -0.9 -0.3
Mineral and other dietary supplements 1.7 2.2 5.4 1.1 1.4 1.4 1.7 1.1 -2.3 1.5 0.9 -1.7 -1.2 1.5 1.5
Breast cancer (self-reported) 3.0 3.6 9.4 -1.9 -2.0 -2.4 -0.1 -1.3 3.1 -2.0 -0.8 -0.8 -0.4 -2.3 -2.8
Asthma (self-reported) 1.0 2.0 3.9 -1.8 -0.9 -1.8 -1.4 -1.7 0.3 -0.9 -0.5 -2.0 -1.6 -1.9 -0.6
Osteoporosis (self-reported) 0.9 1.1 2.5 -0.8 -1.6 -1.3 -1.2 -1.3 0.2 -1.2 -0.5 -0.5 -1.1 -0.9 -1.3
Osteoarthritis (self-reported) 0.3 0.5 1.5 -0.2 0.2 0.1 -0.3 1.0 0.5 -0.3 1.2 1.1 0.8 0.6 -0.4
Medication: Aspirin 0.9 1.2 3.0 -0.6 -0.8 -1.1 0.9 -1.6 1.2 -0.5 -1.7 -0.9 -0.3 -1.6 -0.5
Medication: Gliclazide 0.5 0.5 2.0 0.2 1.0 0.8 0.7 1.4 -0.4 0.0 0.9 0.2 0.0 0.9 0.5
Illnesses of father: None of the above (group 1) 2.3 2.9 6.4 2.5 1.6 2.0 1.3 1.0 -1.6 2.1 1.0 0.0 1.1 2.2 2.2
Smoking status: Current 2.2 3.5 8.2 -1.8 -2.2 -2.2 -1.3 -1.3 1.6 -2.9 -1.4 -1.3 -1.4 -2.0 -2.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.7 3.6 7.6 1.2 2.5 2.4 2.0 2.8 -2.3 1.3 1.7 0.7 0.1 2.5 1.5
Whole body water mass 0.9 5.0 14.2 -0.6 -2.9 -2.5 -0.8 -3.8 2.6 -0.8 -3.2 -0.0 1.1 -2.9 -1.5
Leg predicted mass (right) 0.9 4.7 12.7 -0.6 -3.0 -2.6 -0.6 -3.6 2.6 -0.8 -3.2 0.0 1.1 -2.6 -1.5
Arm fat mass (left) 0.9 3.6 9.8 -1.7 -3.1 -2.6 -1.2 -1.5 2.3 -1.9 -0.3 1.5 0.8 -1.6 -2.5
Number of self-reported non-cancer illnesses 1.1 1.9 8.4 -1.4 -1.0 -1.9 -0.0 -1.1 2.9 -0.6 -0.0 0.4 0.5 -1.9 -1.6
Average weekly champagne plus white wine intake 6.8 9.3 15.6 3.4 3.5 3.9 2.3 2.6 -3.3 3.2 1.9 1.8 1.9 3.9 3.6
Miserableness 0.3 0.5 1.5 0.7 0.4 -0.2 0.0 -0.6 1.0 0.4 -1.2 -0.7 0.9 -0.5 0.5
Guilty feelings 0.5 0.7 2.0 -0.5 0.1 -0.6 1.4 -0.7 1.4 0.6 -1.4 0.3 1.0 -0.6 -0.2
Wears glasses or contact lenses 1.5 1.8 4.4 -2.1 -1.5 -1.6 -0.2 -0.2 1.5 -1.8 -0.5 -0.0 -0.6 -1.3 -2.1
Ever taken oral contraceptive pill 1.4 1.6 4.3 0.5 1.0 1.0 -0.5 1.6 -0.1 0.4 1.9 2.1 1.8 1.4 0.8
Hearing aid user 0.4 0.4 1.0 -0.6 -0.7 -0.5 0.5 -0.6 -0.1 -0.4 -0.7 -0.5 -1.0 -0.7 -0.8
Mother’s age at death 0.7 0.8 3.0 -0.8 -0.6 -0.6 0.5 -0.5 0.3 0.0 -1.1 -1.7 -1.6 -1.1 -0.5
Financial situation satisfaction 0.2 0.3 1.6 -0.2 -0.6 -0.1 -0.5 0.2 0.2 -1.3 0.2 0.8 0.5 0.0 -0.4
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.2 0.2 0.6 -0.0 0.8 0.9 1.2 0.0 1.5 1.2 1.2 0.3 0.2
Commuting to job workplace: Public transport 0.5 0.6 4.6 -0.1 0.7 0.5 2.1 0.6 1.0 0.4 -0.3 0.1 0.1 -0.5 -0.4
Eye problems/disorders: Glaucoma 0.1 0.1 0.4 -0.2 0.1 -0.1 -0.3 0.4 -0.0 0.3 0.6 0.1 0.0 0.1 -0.1
Medication: Blood pressure 0.2 0.4 1.5 0.9 -0.2 0.4 -1.0 0.5 -0.4 0.4 0.6 0.1 0.3 1.2 0.1
Pain type(s) experienced in last month: Hip pain 1.0 1.3 2.6 -1.4 -0.8 -1.5 -0.5 -0.8 1.6 -1.1 -0.9 -0.7 -0.7 -1.6 -1.3
Supplements: Fish oil (including cod liver oil) 1.6 2.1 5.4 -1.1 -1.6 -1.5 -1.0 -1.2 2.3 -1.8 -0.7 1.1 0.8 -1.6 -1.7
High cholesterol (Self-reported) 1.0 1.8 3.2 1.4 1.4 1.5 1.8 1.3 -1.7 1.0 1.2 -0.3 -0.6 1.6 1.3
Medication: Bendroflumethiazide 0.3 0.5 1.3 1.0 0.0 0.6 -1.0 0.9 -0.1 0.4 0.8 0.6 0.6 1.1 0.2
Medication: Paracetamol 1.0 1.6 6.2 -1.0 -1.1 -1.7 -1.0 -1.2 2.5 -0.8 -0.5 0.5 0.6 -1.6 -1.1
Medication: Lisinopril 0.3 0.4 1.6 -0.7 -0.0 -0.3 0.1 -0.3 0.9 -0.2 -0.2 1.2 1.3 -0.4 -0.1
Medication: Atorvastatin 0.5 0.6 1.8 1.1 -0.1 0.5 0.6 0.5 -0.1 -0.3 1.3 1.2 1.0 1.0 0.3
Illnesses of father: High blood pressure 0.4 0.5 1.1 -0.6 -0.9 -0.9 -1.0 -0.5 0.8 -1.0 0.7 0.2 0.0 -0.4 -0.9
Alcohol drinker status: Never 1.6 1.9 4.2 0.5 1.6 1.6 0.6 1.9 -1.3 1.1 2.0 1.0 0.6 1.7 1.5
Ever smoked 0.3 0.6 2.0 1.1 -0.2 -0.2 -0.6 -1.2 0.5 0.2 -1.4 -0.6 0.9 -0.1 0.7
Basal metabolic rate 0.9 5.1 13.2 -0.8 -3.1 -2.7 -0.9 -3.6 2.7 -1.0 -2.9 0.3 1.1 -2.8 -1.8
Leg fat percentage (left) 1.0 3.7 7.8 -2.2 -2.8 -2.2 -1.1 -0.2 2.1 -2.1 1.3 2.4 0.8 -0.9 -2.8
Arm fat-free mass (left) 0.9 4.4 10.8 -0.9 -3.0 -2.5 -0.9 -3.3 2.4 -1.1 -2.7 0.4 0.7 -2.6 -1.9
Number of operations (self-reported) 1.8 2.6 5.0 -1.6 -1.6 -2.2 -0.2 -1.1 2.0 -1.0 -0.9 -2.1 -1.6 -2.0 -1.8
Average weekly beer plus cider intake 1.2 1.7 7.0 1.4 1.3 1.3 2.6 1.2 -0.3 1.9 0.9 0.2 0.7 1.1 0.9
Irritability 0.3 0.5 2.0 0.3 -0.0 -0.4 -1.1 0.1 1.0 0.0 0.8 1.1 1.4 0.4 0.2
Risk taking 0.3 0.4 1.4 -0.4 -0.2 -0.5 -0.6 -1.2 -0.3 -0.7 -0.3 -0.7 -0.7 -0.9 0.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 2.8 0.5 0.2 -0.2 1.7 -0.2 0.7 0.1 -0.3 -0.7 0.0 -0.1 0.2
Fractured/broken bones in last 5 years 0.6 0.7 2.0 -0.6 -1.4 -1.1 -1.1 -1.2 0.0 -1.1 0.1 -0.1 -0.7 -0.7 -0.8
Age started oral contraceptive pill 0.3 0.3 1.1 0.8 0.2 0.8 0.5 0.4 -0.1 0.8 -0.1 0.5 1.0 0.5 0.3
Diastolic blood pressure, automated reading 0.4 1.4 5.0 -0.5 -1.3 -0.5 -1.8 0.9 -0.3 -1.0 2.2 1.4 -0.4 0.8 -1.2
Ever depressed for a whole week 0.5 0.7 2.2 -0.2 1.0 0.6 1.5 1.5 -0.3 0.9 1.0 0.4 -0.2 0.6 0.1
Unable to work because of sickness or disability 5.6 7.3 16.6 -2.6 -2.9 -3.9 -1.0 -4.1 2.8 -2.6 -2.2 -1.1 -0.5 -3.8 -2.0
Commuting to job workplace: Cycle 1.2 1.4 3.4 1.4 1.7 1.4 0.6 0.4 -1.3 1.3 -0.8 -1.3 -0.3 0.7 1.9
Myopia 0.2 0.3 1.9 -0.0 0.0 0.3 0.7 -0.3 0.2 0.1 -1.4 -0.4 -0.1 -0.5 -0.2
Vascular/heart problems diagnosed by doctor 0.6 1.8 3.6 1.4 1.9 1.7 1.6 0.7 -1.7 1.2 -0.2 -0.0 0.4 1.2 1.9
Cholesterol lowering medication 0.5 0.8 2.6 0.0 0.0 0.5 1.2 0.9 -1.2 0.1 1.1 -0.7 -1.6 0.8 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 3.9 0.8 1.6 1.5 0.1 2.0 -1.2 0.5 1.9 -1.0 -0.9 1.2 1.2
Pain experienced in last month 0.6 1.0 5.0 0.7 0.7 1.3 0.1 0.7 -2.2 0.7 0.6 -0.7 -1.1 1.1 0.7
Supplements: Calcium 2.2 2.5 8.3 -1.1 -1.6 -1.4 -0.1 -2.3 1.3 -0.9 -2.9 -0.8 -0.7 -2.3 -1.2
Basal cell carcinoma (self-reported) 0.9 1.1 6.6 -0.2 -1.3 -0.9 -2.6 -1.3 0.5 -0.4 -0.5 -0.7 -0.1 -0.9 -0.2
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.6 -0.6 -0.6 -0.2 -0.8 0.4 0.1 -1.3 0.2 -0.5 -1.1 -0.3 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 2.0 -0.7 -0.4 -0.9 0.5 -0.8 1.4 -0.1 -0.2 -0.4 0.4 -1.1 -0.4
Heart disease (siblings) 2.3 2.9 7.9 -2.8 -1.4 -2.4 -1.6 -1.1 1.9 -1.3 0.0 -1.2 -1.1 -2.1 -1.8
Alcohol drinker status: Previous 0.5 0.5 1.8 0.3 0.4 -0.7 0.8 -0.8 1.3 0.8 0.3 -0.5 0.9 -0.9 0.5
Pack years of smoking 3.5 5.1 9.9 -2.3 -2.6 -2.4 -2.5 -2.5 1.2 -2.5 -1.4 -1.4 -2.2 -3.1 -2.2
Impedance of whole body 0.2 1.0 1.4 1.1 0.9 1.1 1.1 1.2 -1.0 1.2 0.9 -0.6 -0.4 1.2 0.7
Leg fat mass (left) 1.1 4.4 10.3 -2.0 -3.2 -2.7 -1.4 -1.4 2.6 -2.1 0.1 2.1 1.1 -1.5 -2.7
Arm predicted mass (left) 0.8 4.3 10.6 -0.8 -3.0 -2.5 -1.1 -3.2 2.4 -0.9 -2.6 0.6 1.0 -2.5 -1.8