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chr1:149,672,809-152,712,747

Best TWAS P=1.46e-99 · Best GWAS P=8.84e-193 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MRPS21	0.06	0.04	lasso	7	0.04	5.7e-06	2.65	6.0	1.9e-09	0.15	0.81	0.01	FALSE
2	GTEx	Adipose Subcutaneous	MTMR11	0.08	0.04	lasso	4	0.05	3.5e-05	-13.24	-13.8	1.9e-43	-0.37	0.78	0.03	FALSE
3	GTEx	Adipose Subcutaneous	RP11-196G18.22	0.13	0.02	enet	16	0.06	6.4e-06	0.69	7.1	1.3e-12	0.44	0.10	0.15	TRUE
4	GTEx	Artery Aorta	CTSK	0.23	0.00	enet	24	0.02	3.9e-02	1.58	-7.3	3.4e-13	0.02	0.10	0.04	TRUE
5	GTEx	Artery Aorta	RPRD2	0.08	-0.01	enet	19	0.00	4.2e-01	1.18	9.9	2.5e-23	0.30	0.08	0.26	FALSE
6	GTEx	Artery Aorta	MRPS21	0.09	0.08	lasso	4	0.06	5.1e-04	-4.80	5.4	5.7e-08	0.02	0.26	0.03	FALSE
7	GTEx	Artery Tibial	HIST2H2AA3	0.22	0.02	enet	20	0.12	1.8e-09	26.29	20.5	1.0e-93	0.70	0.00	1.00	FALSE
8	GTEx	Artery Tibial	RP11-196G18.22	0.25	0.05	lasso	5	0.07	1.8e-06	15.41	21.2	1.5e-99	0.78	0.01	0.98	TRUE
9	GTEx	Artery Tibial	RP11-196G18.24	0.31	0.08	enet	26	0.10	6.1e-08	26.29	18.9	6.5e-80	0.72	0.00	0.99	FALSE
10	GTEx	Brain Caudate basal ganglia	PIP5K1A	0.40	0.18	lasso	6	0.17	1.0e-05	-9.54	-9.5	2.9e-21	-0.05	0.12	0.05	TRUE
11	GTEx	Brain Cerebellar Hemisphere	SEMA6C	0.39	0.01	enet	31	0.10	1.3e-03	-4.52	-6.0	1.7e-09	0.04	0.18	0.06	FALSE
12	GTEx	Brain Cerebellum	SNX27	0.27	0.00	enet	30	0.06	7.0e-03	1.39	-6.1	1.1e-09	-0.02	0.11	0.06	TRUE
13	GTEx	Brain Cerebellum	SEMA6C	0.52	0.21	lasso	15	0.22	2.9e-07	-3.34	-6.6	4.4e-11	-0.11	0.85	0.01	TRUE
14	GTEx	Brain Cortex	CTSS	0.17	0.06	lasso	6	0.04	2.7e-02	4.75	5.2	2.5e-07	-0.06	0.11	0.05	FALSE
15	GTEx	Breast Mammary Tissue	SEMA6C	0.11	0.02	lasso	2	0.02	4.0e-02	-5.26	-5.7	1.3e-08	-0.11	0.07	0.09	FALSE
16	GTEx	Breast Mammary Tissue (Male)	SETDB1	0.13	0.00	enet	7	0.04	3.8e-02	3.79	-6.0	1.5e-09	0.04	0.08	0.06	FALSE
17	GTEx	Breast Mammary Tissue (Female)	SEMA6C	0.03	-0.01	lasso	1	-0.01	8.7e-01	-5.26	-5.3	1.4e-07	-0.02	0.03	0.05	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	SNX27	0.29	0.05	enet	55	0.09	6.7e-04	-3.64	-5.9	4.1e-09	0.03	0.26	0.04	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	S100A11	0.37	0.26	lasso	5	0.22	6.8e-08	-4.61	-5.2	1.9e-07	-0.05	0.90	0.04	FALSE
20	GTEx	Esophagus Muscularis	CTSS	0.05	0.04	enet	12	0.06	1.2e-04	3.13	6.1	1.1e-09	0.10	0.64	0.07	FALSE
21	GTEx	Esophagus Muscularis	BOLA1	0.07	0.00	lasso	4	0.00	2.5e-01	-12.38	11.4	6.4e-30	0.43	0.03	0.13	FALSE
22	GTEx	Heart Left Ventricle	MTMR11	0.11	0.05	lasso	3	0.05	9.3e-04	-12.38	-10.4	2.7e-25	-0.39	0.20	0.13	FALSE
23	GTEx	Heart Left Ventricle	MRPS21	0.15	0.09	lasso	6	0.10	7.3e-06	-4.89	5.5	4.8e-08	0.05	0.78	0.01	FALSE
24	GTEx	Lung	MTMR11	0.08	0.04	lasso	8	0.03	3.0e-03	-13.24	-13.1	2.2e-39	-0.29	0.19	0.11	FALSE
25	GTEx	Nerve Tibial	SEMA6C	0.15	0.01	enet	15	0.02	1.4e-02	-4.08	-6.9	4.6e-12	-0.04	0.52	0.04	FALSE
26	GTEx	Nerve Tibial	MRPS21	0.13	0.02	lasso	9	0.02	9.4e-03	-4.89	6.4	1.5e-10	0.08	0.69	0.02	FALSE
27	GTEx	Ovary	SEMA6C	0.29	0.13	enet	11	0.14	2.6e-04	-3.86	-7.5	5.6e-14	-0.22	0.18	0.07	FALSE
28	GTEx	Pancreas	THEM4	0.16	0.19	lasso	2	0.19	1.8e-08	4.71	-5.2	1.5e-07	0.06	0.94	0.01	FALSE
29	GTEx	Skin Sun Exposed Lower leg	MTMR11	0.03	0.01	lasso	5	0.00	1.2e-01	-12.38	-9.3	1.5e-20	-0.39	0.05	0.05	FALSE
30	GTEx	Skin Sun Exposed Lower leg	ANXA9	0.12	0.04	lasso	3	0.08	3.8e-07	-6.15	5.2	1.8e-07	0.13	0.98	0.00	FALSE
31	GTEx	Skin Sun Exposed Lower leg	SV2A	0.07	0.00	enet	15	0.02	6.0e-03	-2.18	-11.5	1.9e-30	-0.16	0.07	0.12	FALSE
32	GTEx	Skin Sun Exposed Lower leg	THEM4	0.12	0.04	enet	14	0.07	2.5e-06	5.05	-5.5	3.3e-08	0.06	0.81	0.16	FALSE
33	GTEx	Skin Sun Exposed Lower leg	MRPS21	0.07	0.06	enet	9	0.08	1.6e-07	-4.85	5.4	5.9e-08	0.02	0.96	0.00	FALSE
34	GTEx	Spleen	MRPS21	0.23	0.02	enet	27	0.07	7.8e-03	-4.89	5.1	2.8e-07	0.16	0.11	0.06	TRUE
35	GTEx	Testis	ANXA9	0.30	0.19	enet	22	0.15	2.7e-07	-6.15	7.1	1.6e-12	0.10	0.92	0.00	TRUE
36	GTEx	Thyroid	MTMR11	0.09	0.05	enet	9	0.06	1.5e-05	-12.40	-11.9	1.4e-32	-0.40	0.26	0.42	FALSE
37	GTEx	Thyroid	C1orf54	0.10	0.04	enet	15	0.08	2.0e-06	7.66	-7.1	1.1e-12	-0.18	0.36	0.02	FALSE
38	GTEx	Thyroid	PRUNE	0.11	0.00	enet	21	0.03	3.1e-03	-5.74	-6.3	2.5e-10	-0.07	0.42	0.03	FALSE
39	GTEx	Thyroid	ANXA9	0.10	0.06	lasso	3	0.05	2.0e-04	-4.64	5.2	1.9e-07	0.17	0.24	0.04	FALSE
40	GTEx	Uterus	MRPS21	0.28	0.03	lasso	10	0.05	3.2e-02	-4.95	6.1	1.4e-09	0.08	0.07	0.06	FALSE
41	GTEx	Vagina	PSMB4	0.25	-0.01	enet	24	0.00	3.2e-01	-5.77	8.9	6.4e-19	-0.05	0.05	0.06	FALSE
42	METSIM	Adipose	ENSA	0.05	0.00	bslmm	291	0.02	1.5e-03	-4.84	-6.8	8.8e-12	0.00	0.30	0.11	FALSE
43	METSIM	Adipose	LINC00568	0.06	0.01	bslmm	275	0.00	1.5e-01	2.51	7.1	9.5e-13	0.12	0.06	0.03	FALSE
44	METSIM	Adipose	PSMD4	0.03	0.05	lasso	4	0.04	6.1e-07	-8.11	7.2	5.6e-13	0.22	0.99	0.00	FALSE
45	NTR	Blood	ANP32E	0.01	0.01	enet	6	0.00	1.3e-02	2.42	5.9	4.2e-09	0.05	0.49	0.01	FALSE
46	NTR	Blood	PRUNE	0.03	0.01	lasso	7	0.02	2.3e-07	-6.90	-7.1	1.7e-12	-0.03	0.95	0.00	FALSE
47	YFS	Blood	PRUNE	0.05	0.00	enet	33	0.02	5.8e-06	-5.62	-5.8	9.0e-09	-0.06	0.12	0.02	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PPIAL4C	0.06	0.03	enet	6	0.04	1.3e-04	-9.22	-6.1	9.8e-10	-0.27	0.01	0.04	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	PIP5K1A	0.04	0.05	lasso	6	0.05	8.8e-10	-8.92	-9.3	1.6e-20	-0.15	0.99	0.01	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	SV2A	0.03	0.02	enet	3	0.02	8.0e-06	-2.31	7.8	5.4e-15	0.38	0.13	0.23	FALSE
51	The Cancer Genome Atlas	Colon Adenocarcinoma	PIP5K1A	0.05	0.03	blup	35	0.04	4.0e-03	-7.40	-9.3	8.5e-21	-0.19	0.10	0.44	FALSE
52	The Cancer Genome Atlas	Esophageal Carcinoma	C1orf54	0.13	0.08	enet	7	0.11	2.2e-04	-7.75	-6.7	1.9e-11	-0.03	0.00	0.95	FALSE
53	The Cancer Genome Atlas	Esophageal Carcinoma	PIP5K1A	0.10	0.06	lasso	1	0.04	2.1e-02	-8.88	-8.9	6.5e-19	-0.16	0.02	0.33	TRUE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LYSMD1	0.06	0.03	blup	32	0.03	3.9e-04	-5.26	-8.5	2.2e-17	-0.16	0.22	0.16	TRUE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMB4	0.03	0.00	blup	37	0.02	7.0e-03	-3.53	5.3	1.3e-07	0.13	0.07	0.12	FALSE
56	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SV2A	0.05	0.02	blup	9	0.03	2.5e-04	-12.38	12.6	3.6e-36	0.48	0.03	0.07	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	THEM4	0.06	0.06	blup	59	0.06	2.4e-07	5.12	-6.0	1.5e-09	0.05	0.97	0.02	TRUE
58	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MRPS21	0.14	0.08	enet	14	0.08	2.0e-05	-4.85	7.3	2.2e-13	0.07	0.32	0.24	FALSE
59	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSS	0.29	0.08	lasso	3	0.08	1.5e-09	-5.29	5.2	2.0e-07	0.17	0.00	1.00	TRUE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	PIP5K1A	0.02	0.02	lasso	3	0.02	6.2e-03	-7.40	-8.6	6.2e-18	-0.19	0.09	0.07	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	SV2A	0.04	0.00	blup	9	0.03	5.5e-04	-12.10	-12.2	1.7e-34	-0.21	0.00	0.33	TRUE
62	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	MTMR11	0.12	0.09	blup	11	0.10	1.3e-05	-12.38	-6.2	6.8e-10	-0.18	0.08	0.07	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	ADAMTSL4	0.02	0.00	blup	33	0.02	4.7e-03	-4.45	5.5	3.2e-08	0.04	0.02	0.36	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	BNIPL	0.02	0.04	lasso	1	0.02	4.9e-03	-5.73	-5.7	1.0e-08	0.03	0.12	0.17	FALSE
65	The Cancer Genome Atlas	Lung Adenocarcinoma	C1orf54	0.04	0.02	blup	17	0.02	1.4e-03	4.24	-6.9	4.3e-12	-0.11	0.09	0.10	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	PIP5K1A	0.03	0.01	blup	36	0.02	5.1e-03	-8.67	-8.5	1.9e-17	-0.13	0.03	0.68	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C1orf54	0.19	0.04	enet	6	0.09	1.2e-04	-5.71	-6.0	1.6e-09	-0.17	0.01	0.18	TRUE
68	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RFX5	0.19	0.01	blup	30	0.07	5.3e-04	1.67	-6.2	5.9e-10	-0.08	0.00	0.48	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	ENSA	0.02	0.01	enet	3	0.01	2.5e-02	5.02	-6.3	2.5e-10	0.08	0.00	0.77	FALSE
70	The Cancer Genome Atlas	Prostate Adenocarcinoma	MTMR11	0.02	0.02	lasso	3	0.02	3.7e-03	-13.24	-13.3	1.2e-40	-0.30	0.03	0.03	FALSE
71	The Cancer Genome Atlas	Prostate Adenocarcinoma	SF3B4	0.03	0.02	blup	10	0.01	1.4e-02	-13.24	-14.1	2.0e-45	-0.32	0.04	0.16	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	SV2A	0.11	0.10	blup	9	0.11	3.8e-11	-2.31	8.2	1.7e-16	0.40	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Skin Cutaneous Melanoma	FCGR1A	0.10	0.03	lasso	4	0.04	3.9e-02	-12.38	9.3	1.8e-20	0.38	0.01	0.06	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	ANXA9	0.10	0.05	lasso	4	0.04	4.1e-05	-6.80	6.0	1.6e-09	0.19	0.55	0.27	TRUE
75	The Cancer Genome Atlas	Thyroid Carcinoma	MRPS21	0.07	0.01	blup	15	0.02	1.7e-03	2.51	6.7	1.7e-11	0.08	0.13	0.16	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	PIP5K1A	0.04	0.06	lasso	2	0.05	9.7e-06	-8.92	-9.1	1.3e-19	-0.15	0.54	0.36	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	RFX5	0.03	0.03	blup	31	0.03	5.9e-04	-7.60	-7.4	1.4e-13	-0.23	0.05	0.08	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	SELENBP1	0.06	0.02	enet	7	0.05	2.3e-05	-3.53	-6.6	3.3e-11	-0.13	0.54	0.11	FALSE