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chr9:135,521,303-137,724,371

Best TWAS P=2.29e-28 · Best GWAS P=8.35e-23 conditioned to 0.24

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BRD3	0.18	0.16	lasso	5	0.16	3.6e-19	7.6	-8.2	2.6e-16	-0.68	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	BRD3	0.24	0.06	enet	51	0.09	1.7e-07	9.5	-8.4	4.6e-17	-0.56	0.04	0.96	FALSE
3	GTEx	Adipose Subcutaneous	WDR5	0.13	0.08	lasso	1	0.05	5.8e-05	-5.7	-5.7	1.6e-08	-0.01	0.88	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	BRD3	0.21	0.01	lasso	5	0.00	1.8e-01	9.8	-9.9	3.7e-23	-0.99	0.01	0.94	FALSE
5	GTEx	Artery Aorta	BRD3	0.34	0.03	lasso	9	0.09	7.9e-06	9.0	-9.2	3.9e-20	-0.75	0.00	0.99	FALSE
6	GTEx	Artery Tibial	CACFD1	0.10	0.03	lasso	4	0.03	1.7e-03	4.0	-7.0	3.4e-12	-0.06	0.03	0.85	TRUE
7	GTEx	Artery Tibial	BRD3	0.17	0.03	enet	14	0.09	1.5e-07	-3.1	-10.1	6.4e-24	-0.63	0.05	0.94	FALSE
8	GTEx	Artery Tibial	WDR5	0.26	0.12	lasso	7	0.13	3.2e-10	-5.7	-5.7	1.1e-08	-0.03	1.00	0.00	TRUE
9	GTEx	Brain Cerebellum	SURF1	0.60	0.24	enet	38	0.44	2.7e-14	-3.6	5.8	7.9e-09	0.07	0.98	0.02	FALSE
10	GTEx	Brain Frontal Cortex BA9	SURF1	0.70	0.26	lasso	16	0.44	4.3e-13	3.8	5.3	9.0e-08	0.08	0.89	0.06	FALSE
11	GTEx	Breast Mammary Tissue	AL590710.1	0.31	0.11	lasso	7	0.12	1.3e-06	3.2	-6.7	1.6e-11	-0.11	0.55	0.06	TRUE
12	GTEx	Cells Transformed fibroblasts	BRD3	0.29	0.23	lasso	4	0.27	3.7e-20	9.0	-9.9	6.0e-23	-0.96	0.00	1.00	FALSE
13	GTEx	Cells Transformed fibroblasts	WDR5	0.26	0.16	lasso	3	0.16	4.6e-12	-5.1	-5.4	8.1e-08	-0.03	1.00	0.00	FALSE
14	GTEx	Colon Transverse	SURF1	0.41	0.11	enet	25	0.29	3.8e-14	-3.6	5.6	2.5e-08	0.07	0.98	0.01	FALSE
15	GTEx	Esophagus Mucosa	BRD3	0.19	0.06	lasso	5	0.11	1.5e-07	7.6	-10.4	3.9e-25	-0.76	0.02	0.98	FALSE
16	GTEx	Esophagus Muscularis	BRD3	0.18	0.03	enet	14	0.09	5.8e-06	9.5	-9.7	2.4e-22	-0.74	0.01	0.99	FALSE
17	GTEx	Nerve Tibial	BRD3	0.23	0.10	lasso	5	0.16	2.7e-11	9.4	-11.0	2.3e-28	-0.84	0.00	1.00	TRUE
18	GTEx	Skin Not Sun Exposed Suprapubic	BRD3	0.31	0.08	enet	46	0.13	1.0e-07	7.6	-6.7	2.5e-11	-0.56	0.06	0.93	FALSE
19	GTEx	Skin Sun Exposed Lower leg	SURF1	0.45	0.25	lasso	9	0.42	5.1e-38	4.5	5.2	1.6e-07	0.07	1.00	0.00	FALSE
20	GTEx	Skin Sun Exposed Lower leg	BRD3	0.18	0.12	lasso	7	0.11	1.2e-09	7.6	-9.6	8.0e-22	-0.80	0.02	0.98	FALSE
21	GTEx	Skin Sun Exposed Lower leg	LINC00094	0.14	0.01	enet	40	0.03	1.7e-03	-5.1	-8.1	6.0e-16	-0.52	0.03	0.95	FALSE
22	GTEx	Stomach	SURF1	0.23	0.01	enet	31	0.06	5.8e-04	1.4	5.6	2.5e-08	0.04	0.14	0.07	FALSE
23	GTEx	Testis	BRD3	0.20	0.18	lasso	3	0.18	3.2e-08	9.0	-9.2	4.5e-20	-0.66	0.13	0.87	FALSE
24	GTEx	Thyroid	BRD3	0.18	0.07	enet	34	0.06	1.7e-05	7.6	-6.8	7.8e-12	-0.48	0.02	0.96	FALSE
25	GTEx	Uterus	SURF1	0.40	0.05	enet	18	0.08	9.2e-03	-6.4	6.1	8.7e-10	0.02	0.06	0.25	FALSE
26	METSIM	Adipose	BRD3	0.25	0.13	bslmm	590	0.20	1.7e-29	4.8	-8.5	2.6e-17	-0.64	0.83	0.17	FALSE
27	NTR	Blood	BRD3	0.04	0.04	bslmm	555	0.04	5.7e-12	9.0	-8.2	1.7e-16	-0.67	0.20	0.80	FALSE
28	YFS	Blood	BRD3	0.10	0.09	lasso	4	0.10	1.5e-31	4.8	-7.3	2.8e-13	-0.66	0.92	0.08	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	BRD3	0.07	0.11	lasso	3	0.12	4.2e-23	9.4	-10.4	3.1e-25	-0.78	0.09	0.91	FALSE
30	The Cancer Genome Atlas	Colon Adenocarcinoma	BRD3	0.15	0.11	lasso	4	0.12	3.7e-07	9.8	-9.6	8.5e-22	-0.94	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	BRD3	0.10	0.03	enet	11	0.06	9.2e-08	8.8	-7.5	9.4e-14	-0.70	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BRD3	0.09	0.10	lasso	4	0.08	9.5e-10	9.0	-10.2	2.9e-24	-0.82	0.25	0.75	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	BRD3	0.06	0.01	blup	59	0.03	1.6e-04	8.8	-9.5	2.0e-21	-0.71	0.01	0.82	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	BRD3	0.04	0.01	enet	14	0.03	3.1e-04	9.4	-10.7	6.4e-27	-0.61	0.02	0.74	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NCRNA00094	0.03	0.03	enet	5	0.04	1.7e-05	4.4	7.7	9.7e-15	0.41	0.15	0.64	FALSE
36	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	BRD3	0.14	0.02	blup	60	0.09	2.0e-04	8.2	-9.4	5.6e-21	-0.71	0.03	0.61	FALSE
37	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SURF1	0.16	0.06	blup	31	0.06	1.4e-03	4.5	5.5	4.3e-08	0.05	0.00	0.74	FALSE
38	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BRD3	0.09	0.03	blup	60	0.01	1.1e-01	9.0	-10.8	5.1e-27	-0.76	0.02	0.52	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	BRD3	0.09	0.07	lasso	3	0.07	1.3e-07	9.0	-8.7	4.8e-18	-0.90	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	NCRNA00094	0.04	0.00	blup	52	0.02	5.2e-03	4.4	6.4	1.4e-10	0.34	0.07	0.16	FALSE
41	The Cancer Genome Atlas	Rectum Adenocarcinoma	BRD3	0.32	-0.01	blup	60	0.02	9.8e-02	9.8	-8.5	1.5e-17	-0.81	0.01	0.59	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	BRD3	0.07	0.04	enet	12	0.04	4.3e-04	9.0	-9.6	7.7e-22	-0.77	0.02	0.88	FALSE
43	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SURF1	0.15	0.07	blup	30	0.05	6.1e-03	4.5	5.4	8.0e-08	0.04	0.00	0.34	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	BRD3	0.12	0.18	enet	8	0.21	8.4e-20	9.4	-10.5	1.3e-25	-0.88	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ABO	0.23	0.07	blup	44	0.12	4.3e-04	-4.2	-5.3	1.1e-07	-0.01	0.02	0.15	FALSE