TWAS hub - CACFD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1009	0.0431	9.5e-03	0.030	NA	0.024	NA	0.031	2.0e-03	NA	5.1e-03	NA	1.7e-03
2	GTEx	Colon Transverse	0.1710	0.0680	9.7e-03	-0.005	NA	-0.006	NA	-0.006	7.1e-01	NA	8.2e-01	NA	9.0e-01
3	GTEx	Esophagus Mucosa	0.2340	0.0570	6.2e-06	0.174	NA	0.191	NA	0.182	9.0e-12	NA	8.1e-13	NA	3.0e-12
4	GTEx	Testis	0.2580	0.0790	2.4e-04	0.053	NA	0.095	NA	0.047	2.1e-03	NA	5.3e-05	NA	3.8e-03
5	GTEx	Thyroid	0.2420	0.0520	3.2e-07	0.180	NA	0.132	NA	0.149	9.8e-14	NA	2.6e-10	NA	1.7e-11
6	METSIM	Adipose	0.0691	0.0238	6.7e-04	0.001	0.009	-0.001	0.008	-0.001	2.2e-01	0.013	6.3e-01	0.017	4.7e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Blood clot in the leg (DVT)	16.4	21.2	60.6	7.8	2.9	-1.4	6.4	-0.5	3.9
Deep venous thrombosis (DVT) (self-reported)	15.9	20.4	55.7	7.5	2.6	-1.4	6.5	-0.5	4.0
Blood Red Count	9.9	96.0	256.0	-16.0	-4.4	8.0	-14.5	5.0	-0.7
LDL Cholesterol	7.3	11.6	30.6	5.5	1.3	-2.4	5.5	-0.6	0.8
Peak expiratory flow (PEF)	5.1	11.8	31.2	-5.6	-1.5	2.7	-5.1	1.9	0.5
Length of working week for main job	3.8	4.2	7.1	2.7	-0.1	-2.2	2.3	-2.1	-1.8
Qualifications: CSEs or equivalent	3.7	4.8	11.4	3.0	0.4	-3.4	1.2	-2.5	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.6	11.4	29.7	-5.5	-2.1	1.9	-5.1	2.1	-0.0
Angina	3.3	4.3	9.1	-2.7	1.0	3.0	-1.6	2.0	1.4
Pulse wave Arterial Stiffness index	3.3	3.9	8.4	-2.9	-0.4	2.1	-1.9	2.2	1.2
Forced vital capacity (FVC), Best measure	3.3	12.2	31.4	-5.6	-1.5	2.6	-5.1	2.6	-0.0
Ovarian Cancer	3.2	4.3	15.1	-2.9	-0.8	0.8	-3.9	0.5	-0.9
Ever used hormone-replacement therapy (HRT)	3.2	4.1	8.8	1.8	-1.4	-2.7	1.9	-3.0	-0.0
Angina (self-reported)	3.2	4.1	8.1	-2.6	1.1	2.8	-1.9	1.8	1.4
Hearing difficulty/problems: Yes	3.1	4.7	10.6	-1.4	2.0	2.0	-1.3	2.4	3.2
Forced expiratory volume in 1-second (FEV1)	3.1	10.6	30.5	-4.9	-2.0	1.5	-5.5	1.7	0.5
Tinnitus: Yes, now most or all of the time	3.1	3.6	8.9	-3.0	1.3	1.7	-2.7	0.9	0.3
Forced vital capacity (FVC)	3.0	11.5	31.4	-5.1	-1.0	2.3	-5.6	2.3	0.6
Father’s age at death	3.0	4.1	10.2	-3.2	-0.1	2.3	-2.2	2.0	-0.4
Sensitivity / hurt feelings	2.9	5.0	8.2	-1.9	0.0	2.1	-2.9	2.4	2.8
Pulse wave peak to peak time	2.8	3.3	6.1	2.5	0.0	-2.0	1.8	-2.2	-1.4
Age at last live birth	2.8	4.0	10.8	-2.9	-0.6	1.8	-3.3	1.2	-0.1
Age at first live birth	2.7	4.8	12.4	-2.7	-1.8	1.8	-3.5	1.7	0.1
Eye problems/disorders: None of the above	2.6	3.0	6.5	0.2	-0.5	-2.2	0.6	-2.5	-2.6
Blood White Count	2.5	18.5	47.9	-6.9	-0.9	3.5	-6.5	1.7	-2.2
Blood Eosinophil Count	2.4	18.5	41.5	-6.4	0.9	5.2	-4.6	4.6	0.2
Pulse wave reflection index	2.4	3.0	5.5	-2.3	2.0	2.0	-1.5	1.2	0.7
High blood pressure (mother)	2.3	3.3	5.4	1.7	-1.8	-2.3	0.7	-2.3	-1.6
Hearing difficulty/problems with background noise	2.3	3.7	6.8	-2.0	0.9	2.6	-1.5	2.4	1.5
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	5.8	2.1	-0.2	-2.4	1.5	-1.9	0.1
High cholesterol (Self-reported)	2.2	3.9	11.4	3.0	1.0	-0.1	3.4	0.5	1.2
Leg pain on walking	2.1	2.6	7.3	2.7	-1.0	-2.3	-0.0	-1.4	0.5
Handedness (chirality/laterality): Left-handed	2.1	2.5	7.1	1.7	-0.7	-0.7	2.7	-1.7	-1.1
Triglycerides	2.0	3.3	5.3	0.3	-2.3	-1.9	1.4	-2.0	-2.1
Lung FVC	2.0	10.3	27.6	-5.2	0.9	3.0	-4.3	2.3	-0.4
Average weekly spirits intake	2.0	2.5	7.9	2.8	0.3	-1.8	1.8	-0.7	0.1
Allergy	2.0	4.7	13.0	-3.1	-1.4	-0.5	-3.6	-1.1	-1.5
Lung cancer (father)	2.0	2.4	4.5	-1.9	0.0	1.7	-1.0	1.5	2.1
Hearing aid user	2.0	2.3	7.4	1.0	2.7	0.3	-0.3	1.0	2.0
Qualifications: College or University degree	1.9	6.1	16.6	-4.1	-0.8	3.2	-0.5	2.9	0.7
Long-standing illness, disability or infirmity	1.9	2.8	10.1	-0.9	0.3	1.2	-1.5	1.5	3.2
Sitting height	1.8	12.5	32.9	-5.7	-3.4	2.8	-4.2	2.2	0.4
Emphysema/chronic bronchitis	1.8	2.0	6.4	1.7	2.5	-0.8	0.9	-1.0	-0.4
Smoking status: Previous	1.8	2.7	3.8	-2.0	1.7	1.7	-1.7	1.8	0.6
Medication: Bendroflumethiazide	1.8	2.7	7.9	0.7	-0.6	-1.4	1.1	-2.0	-2.8
Medication: Atorvastatin	1.8	2.2	6.2	2.1	0.9	-0.5	2.5	-0.3	1.3
Illnesses of father: High blood pressure	1.8	2.2	5.2	-1.7	1.2	1.0	-2.3	0.8	1.4
Verbal and Numeric Reasoning (VNR)	1.7	4.1	7.7	-2.0	0.3	2.8	-2.2	2.1	1.9
Breast Cancer	1.7	4.1	14.3	-3.8	0.0	1.1	-2.9	0.3	-0.7
HbA1C	1.7	1.9	3.9	1.3	0.5	0.4	2.0	1.5	1.7
Irritability	1.7	2.9	6.4	-1.0	1.4	1.5	-2.5	2.1	1.4
Commuting to job workplace: Cycle	1.7	2.1	3.1	-1.8	-1.2	1.5	-0.8	1.6	1.5
Crohns Disease (2012)	1.6	2.5	5.7	-1.1	-1.2	1.6	-0.9	1.8	2.4
Heel T-Score	1.6	12.9	31.6	-5.4	-2.8	2.0	-5.6	0.4	-2.2
Supplements: Glucosamine	1.6	2.0	4.5	-1.6	-1.2	2.1	-1.3	1.2	0.9
Impedance of leg (left)	1.6	7.7	12.2	-3.3	-1.6	3.5	-3.5	2.7	1.0
Past tobacco smoking	1.6	2.9	8.3	1.6	-2.9	-1.7	1.3	-1.4	-0.6
Fluid intelligence score	1.6	3.3	5.9	-2.4	-0.6	2.4	-1.9	1.5	1.3
Birth weight of first child	1.6	3.0	5.3	-2.3	-0.6	2.0	-0.8	2.2	1.6
Medication: Metformin	1.5	2.1	4.3	2.1	-0.0	-0.9	1.9	-1.1	1.7
Pack years adult smoking proportion	1.5	2.3	5.3	1.7	1.9	-0.2	2.3	-1.1	0.9
Impedance of leg (right)	1.5	7.3	13.2	-3.0	-1.5	3.6	-3.0	2.9	1.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	3.3	1.7	0.4	-1.5	1.8	-1.1	0.5
Number of full sisters	1.5	1.9	5.7	0.7	-0.6	-2.1	0.0	-2.4	-0.2
Eye problems/disorders: Cataract	1.5	1.7	5.3	-0.2	-0.1	1.4	-0.2	1.6	2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.3	8.5	-2.9	-1.8	0.3	-2.8	0.1	0.1
Average weekly fortified wine intake	1.4	1.7	8.1	0.3	-1.0	0.2	0.0	0.9	2.8
Medication: Omeprazole	1.4	1.7	8.2	0.1	-0.6	-0.6	0.1	-1.1	-2.9
Illnesses of siblings: Diabetes	1.4	1.7	6.0	-0.7	-1.7	0.6	-0.5	0.4	2.5
Cholesterol lowering medication	1.4	2.0	4.7	1.9	0.6	0.7	2.2	0.6	1.6
Schizophrenia vs Biploar Disorder	1.3	1.8	9.9	0.0	3.1	-0.3	0.3	-0.7	-0.3
Irritable Bowel Disease (IBD)	1.3	3.0	8.5	0.0	-1.1	1.0	-2.0	1.9	2.9
Reaction Time	1.3	2.4	6.2	0.7	-0.6	-2.5	0.8	-2.4	-1.0
Other serious medical condition/disability diagnosed by doctor	1.3	1.6	2.9	-0.9	1.6	1.4	-0.6	1.7	1.1
Pain all over the body in last month	1.3	1.4	3.3	0.4	1.8	-0.7	-1.7	-1.1	-0.3
Medication: Cholesterol lowering	1.3	2.0	7.1	2.7	0.5	-1.0	1.6	-0.0	0.9
Wheeze or whistling in the chest in last year	1.3	2.3	5.4	2.3	1.7	-1.7	1.3	-0.9	0.5
Heart disease (mother)	1.3	1.6	4.7	1.5	0.6	-0.8	2.2	-1.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.3	1.5	2.8	0.9	-1.5	-1.7	-0.5	-1.5	-0.8
Commuting to job workplace: Walk	1.3	1.4	4.2	-1.2	0.4	0.8	-2.0	0.6	1.2
Mother’s age at death	1.3	1.7	4.5	-2.1	0.4	0.9	-1.7	1.2	-0.4
Smoking Status	1.2	2.8	14.0	-0.4	3.7	0.7	-1.3	0.3	-0.5
Current tobacco smoking	1.2	1.9	7.3	1.5	2.7	-0.6	0.9	-0.8	-0.6
Chronic bronchitis/emphysema (father)	1.2	1.4	2.7	-0.3	-1.6	1.3	-1.2	1.6	0.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	4.5	1.2	1.5	0.2	2.1	1.0	0.4
Medication: Simvastatin	1.2	1.8	5.1	1.8	1.4	0.4	0.3	0.7	2.3
Time employed in main current job	1.2	1.4	4.4	0.9	-0.7	-1.2	0.6	-0.9	-2.1
Happiness	1.2	1.5	2.8	-1.4	-1.4	1.7	-0.1	1.4	0.6
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.6	-2.2	1.1	2.6	-0.8	1.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.5	4.8	2.2	-1.1	-1.1	-0.2	-1.0	0.7
Medication: Seretide 50 evohaler	1.2	1.3	5.9	1.1	0.3	-0.1	2.4	-0.8	0.4
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.6	-1.6	-1.2	1.6	-0.1	1.6	0.1
Supplements: Vitamin C	1.2	1.5	3.9	0.8	-0.6	-0.9	0.1	-1.8	-2.0
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	7.1	0.4	-0.3	-0.7	0.2	-0.8	-2.7
Basal cell carcinoma (self-reported)	1.2	1.4	3.5	-0.4	0.4	0.7	-1.9	1.0	1.8
Alzheimer’s Disease (in father)	1.1	1.2	5.2	0.8	-2.3	-0.4	-0.5	-0.8	0.2
Crohns Disease (2017)	1.1	2.5	10.0	0.6	-0.8	0.8	-1.1	1.4	3.2
Schizophrenia (2014)	1.1	2.3	8.2	-2.9	0.4	1.8	-0.2	0.9	-1.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	4.2	1.6	-0.3	-0.2	2.0	-0.3	0.2
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	4.0	-1.9	2.0	0.9	-0.9	1.1	-0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	4.7	0.5	2.2	0.7	-0.0	1.4	1.0
Medication: Ibuprofen	1.1	1.3	2.5	-0.5	-1.2	0.9	-0.9	1.5	1.6
Osteoporosis (self-reported)	1.1	1.4	2.9	-0.3	0.5	1.6	0.7	1.7	1.4
Smoking status: Current	1.1	1.8	7.2	1.3	2.7	-0.7	0.5	-0.9	-0.5
Alcohol drinker status: Never	1.1	1.4	4.9	-1.2	0.8	0.5	-2.2	-0.1	1.0
Pack years of smoking	1.1	1.6	3.1	1.0	1.6	0.5	1.8	-0.4	1.6
Blood Platelet Count	1.0	11.1	26.2	4.8	-2.6	-1.7	5.1	-1.8	-2.0
Allergy or Eczema	1.0	2.5	5.4	-0.1	0.5	2.1	2.3	2.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	9.0	-0.9	-1.5	-0.1	-0.0	-1.2	-3.0
Impedance of arm (right)	1.0	4.7	11.1	1.6	-0.5	2.3	1.6	2.5	3.3
Alcohol intake versus 10 years previously	1.0	1.5	3.9	0.8	0.3	-1.6	-1.3	-2.0	-0.7
Number of live births	1.0	1.4	3.8	-0.8	2.0	-0.2	-0.5	-0.9	-1.7
Standing height	1.0	10.0	28.5	-5.3	-2.0	3.2	-3.2	2.7	0.2
Exposure to tobacco smoke at home	1.0	1.2	3.9	1.1	2.0	-0.6	0.1	-0.3	1.1
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.8	0.3	0.6	0.8	-0.8	1.4	1.9
Mean time to correctly identify matches	1.0	2.0	4.1	0.2	-1.7	-1.9	0.6	-2.0	-0.9
Loneliness, isolation	1.0	1.4	2.9	1.7	-1.7	-1.5	0.6	-0.7	-0.3
Medication: Gliclazide	1.0	1.1	2.5	1.6	-0.1	-1.2	0.9	-1.0	-0.9
Eye problems/disorders: Glaucoma	1.0	1.2	3.7	0.3	0.6	0.9	-1.1	0.9	1.9
Medication: Blood pressure	1.0	2.0	4.7	-0.7	1.6	-0.5	-0.1	-1.9	-2.2
Medication: Lisinopril	1.0	1.2	3.3	-1.8	-0.2	1.1	-1.2	1.0	-0.7
Age started oral contraceptive pill	1.0	1.2	2.6	-1.2	-1.2	1.6	0.5	1.2	0.1
Ulcerative Colitis (UC)	0.9	1.7	4.1	-0.4	-0.6	1.0	-2.0	1.8	1.2
Fasting Glucose	0.9	1.0	2.4	-0.1	-1.6	1.0	0.4	1.4	0.8
Lupus	0.9	1.4	2.9	-0.3	1.2	-0.9	-1.3	-1.7	-1.1
Height	0.9	17.6	48.4	-7.0	-2.5	4.2	-4.8	3.0	0.7
Ever had hysterectomy (womb removed)	0.9	1.0	2.0	1.3	-0.9	-0.6	0.8	-1.4	0.8
Diabetes (mother)	0.9	1.2	2.9	1.7	-0.1	-1.5	-0.0	-0.9	1.1
Medication: Lansoprazole	0.9	1.0	5.5	-0.1	2.3	0.7	0.0	-0.0	0.0
Prospective memory result	0.9	1.2	3.0	1.7	-0.0	-1.0	1.4	-0.9	-0.4
Illnesses of mother	0.9	1.1	1.9	-1.4	1.3	1.3	-0.2	1.0	-0.5
Mood swings	0.9	1.7	6.7	-1.0	1.3	0.4	-2.6	0.4	0.5
Friendships satisfaction	0.9	1.2	3.8	-0.6	-2.0	1.2	0.3	1.1	0.5
Illnesses of father: None of the above (group 1)	0.9	1.2	3.4	-0.2	-0.5	-0.8	1.6	-0.5	-1.8
Average weekly champagne plus white wine intake	0.9	1.2	2.9	-1.4	-0.4	1.3	-0.0	1.7	0.5
Number of operations (self-reported)	0.9	1.4	3.6	1.9	-1.1	-1.2	1.1	-0.9	0.2
Diastolic blood pressure, automated reading	0.9	2.8	8.5	-2.9	-1.1	-0.2	-2.4	-0.8	-0.9
Myopia	0.9	1.3	6.2	-0.3	1.1	-0.5	-2.5	-0.0	0.1
Alzheimer’s Disease (in mother)	0.8	0.9	1.7	-0.9	1.1	1.3	-0.0	1.3	0.4
Diabetes (father)	0.8	1.0	3.5	-0.3	0.3	0.1	-1.4	0.6	1.9
High blood pressure	0.8	2.3	5.2	-1.9	0.2	0.1	-2.0	-1.0	-2.3
Medication: Atenolol	0.8	1.0	4.8	-0.4	0.9	0.3	0.2	-0.1	-2.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.5	1.6	-0.5	-1.5	-0.3	-1.3	-0.8
Mouth/teeth dental problems	0.8	1.2	3.2	-1.4	-1.3	-0.0	-0.2	-0.5	-1.8
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	3.1	1.8	-0.3	-1.3	-0.6	-1.5	-0.2
Mouth/teeth dental problems: Dentures	0.8	1.4	4.1	2.0	-0.0	-0.7	1.1	-1.0	1.2
Impedance of arm (left)	0.8	3.8	7.0	1.8	-0.3	2.0	1.9	2.3	2.7
Tense / ‘highly strung’	0.8	1.4	3.5	-0.3	0.9	0.9	-1.9	0.7	1.6
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.4	0.4	1.6	-1.0	-0.4	-1.3	0.3
Exposure to tobacco smoke outside home	0.8	1.1	3.1	0.5	-0.1	-1.4	-0.9	-1.8	0.6
Worry too long after embarrassment	0.8	1.3	4.5	-0.6	0.4	0.2	-1.4	1.0	2.1
Mouth/teeth dental problems: Loose teeth	0.8	1.0	4.7	0.9	2.2	-0.3	-0.2	0.4	0.5
Arm predicted mass (right)	0.8	4.0	13.7	-3.7	-0.7	0.2	-2.9	0.1	-1.4
Illnesses of father: Heart disease	0.8	1.1	2.1	1.2	-0.2	0.7	0.7	1.4	1.4
Ever had bowel cancer screening	0.8	0.9	1.7	-0.8	0.6	1.1	-1.1	1.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.0	-1.4	-0.1	1.4	-0.9	0.9	0.1
Fractured/broken bones in last 5 years	0.8	1.0	3.0	-0.4	1.7	1.2	0.4	0.9	0.7
Heart attack/myocardial infarction (self-reported)	0.8	1.1	3.5	1.4	0.0	-0.7	1.9	-0.7	0.1
Arm predicted mass (left)	0.8	3.9	11.5	-3.4	-1.5	0.1	-2.8	-0.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.7	1.4	4.1	2.0	-1.3	-0.8	0.3	-1.1	0.8
Medication for hormone replacement therapy	0.7	0.8	1.7	0.8	-0.9	-1.1	1.3	-0.2	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	5.2	-1.2	-0.9	-0.3	-0.5	-1.2	-2.3
Hayfever, allergic rhinitis or eczema	0.7	1.5	4.6	0.4	1.1	1.2	2.2	1.3	-0.0
Stomach or abdominal pain in last month	0.7	0.9	1.7	1.1	-0.7	-1.3	0.3	-1.2	-0.5
Had menopause	0.7	0.9	3.6	0.4	-0.8	0.0	1.9	-0.3	-0.8
Financial difficulties in last 2 years	0.7	1.0	3.1	-1.2	1.0	0.2	-1.8	-0.2	-0.6
Depression (self-reported)	0.7	0.9	2.4	-1.6	0.5	0.8	-0.7	0.8	0.8
Birth weight	0.7	1.5	4.8	0.5	0.9	0.4	0.7	2.2	1.5
High blood pressure (siblings)	0.7	1.0	3.1	-0.5	-1.8	-0.4	-1.2	-1.0	-0.3
Leg fat percentage (right)	0.7	2.6	5.7	-2.4	-1.1	1.8	-2.0	1.0	0.6
Arm fat-free mass (right)	0.7	3.8	12.7	-3.6	-0.6	0.1	-2.7	-0.2	-1.5
Alcohol intake frequency.	0.7	1.6	3.6	-1.6	-1.6	0.8	-1.9	0.4	-0.2
Medication: Aspirin	0.7	0.9	2.5	1.6	-0.2	-0.1	1.3	-0.2	1.1
Hypertension (Self-reported)	0.7	2.0	3.7	-1.8	0.5	0.3	-1.9	-0.9	-1.9
Breast cancer (self-reported)	0.7	0.8	3.1	1.3	0.1	-0.3	1.8	-0.1	-0.2
Guilty feelings	0.7	1.1	2.5	-0.9	-0.7	0.5	-0.7	1.4	1.6
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.8	-1.4	-0.1	0.1	-1.7	0.3	0.6
Medication: Paracetamol	0.7	1.2	2.7	-1.6	-0.5	1.2	-1.2	1.1	0.0
Arm fat-free mass (left)	0.7	3.5	11.5	-3.4	-1.2	0.1	-2.6	-0.3	-1.2
Vascular/heart problems diagnosed by doctor	0.7	1.9	3.5	1.9	-0.4	-0.5	1.8	1.0	1.9
Heart disease (siblings)	0.7	0.8	2.6	0.3	-0.5	1.0	1.6	0.6	0.8
Alcohol drinker status: Previous	0.7	0.8	2.9	-0.6	-0.4	0.4	-1.7	0.8	0.7
Impedance of whole body	0.7	3.7	8.7	-0.5	-0.6	3.0	-0.5	2.7	2.3
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.4	-0.8	-0.9	2.3	-0.3	1.8	0.6
Systolic Blood Pressure	0.6	3.1	7.1	0.0	-2.7	-1.2	1.3	-1.9	-2.3
Serious illness, injury or assault to yourself	0.6	0.8	1.9	1.4	0.3	-1.2	0.2	-0.7	0.6
Hair/balding pattern: Pattern 2	0.6	0.8	2.4	-1.6	0.2	0.4	-1.4	0.1	-0.2
Qualifications: None of the above	0.6	1.3	3.4	1.8	0.8	-1.1	1.0	-1.2	-0.5
Heart attack	0.6	0.8	2.4	1.2	-0.2	-0.7	1.6	-0.7	0.1
Diabetes (self-reported)	0.6	1.0	3.7	1.3	-0.1	0.3	0.2	0.4	1.9
Trunk fat-free mass	0.6	3.4	11.2	-3.3	-1.4	0.1	-2.0	-0.3	-1.7
Worrier / anxious feelings	0.6	1.1	2.4	-1.3	-0.4	1.5	-1.1	0.7	0.8
Trunk predicted mass	0.6	3.4	11.2	-3.3	-1.6	0.2	-2.0	-0.2	-1.6
Medication: Amlodipine	0.6	0.8	2.5	0.2	-0.5	-0.7	0.3	-1.2	-1.6
Suffer from ‘nerves’	0.6	0.9	2.2	0.8	-0.2	-1.0	-0.8	-1.5	0.9
Overall health rating	0.6	1.2	3.4	1.8	0.5	-1.3	0.5	-1.3	-0.5
Family relationship satisfaction	0.6	0.8	2.4	-0.6	-0.8	1.6	0.0	0.8	0.8
Diabetes diagnosed by doctor	0.6	1.0	2.8	1.7	0.5	-0.1	0.7	-0.2	1.5
Mineral and other dietary supplements	0.6	0.8	1.7	1.0	0.8	-1.3	1.0	-0.4	0.2
Financial situation satisfaction	0.6	0.8	1.7	0.5	-0.3	-1.1	0.2	-1.2	-1.3
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.1	-0.5	-1.8	0.0	-0.2	-0.9	-0.8
Ever smoked	0.6	1.0	5.6	0.3	2.4	0.1	-0.2	-0.1	-0.5
Leg fat percentage (left)	0.6	2.3	5.7	-2.4	-1.2	1.5	-1.9	0.7	0.3
Depressed Affect (Nagel 2018)	0.5	1.1	2.3	0.8	0.3	-1.4	-1.5	-1.2	0.1
Schizophrenia (2018)	0.5	0.9	2.4	-1.5	0.7	1.1	0.5	0.3	-1.1
Relative age of first facial hair	0.5	1.1	3.4	-1.2	0.7	1.9	0.0	1.1	-0.4
Maternal smoking around birth	0.5	0.8	1.6	0.9	1.2	-0.1	1.2	-0.9	0.2
Age when periods started (menarche)	0.5	1.3	2.9	0.3	0.8	1.1	0.0	1.7	1.7
Number of incorrect matches in round	0.5	0.7	2.1	-0.6	0.3	1.5	1.1	0.9	0.1
Hip circumference	0.5	2.0	5.5	-2.3	-0.8	1.6	-1.0	1.4	0.1
Hair/balding pattern: Pattern 3	0.5	0.7	2.8	0.7	-0.7	-0.0	1.7	-0.6	-0.2
Noisy workplace	0.5	0.6	1.8	0.3	0.7	-1.3	-0.6	-0.9	-0.4
Asthma	0.5	1.0	3.3	0.8	1.8	0.3	1.5	-0.2	-0.2
Breastfed as a baby	0.5	0.6	1.6	-1.3	-1.1	0.7	-0.1	0.6	0.3
Gout (self-reported)	0.5	0.6	2.2	-0.4	-1.1	-0.3	0.1	-0.4	-1.5
Neck or shoulder pain in last month	0.5	0.7	3.2	0.5	-0.1	-0.6	-0.3	-0.1	1.8
Leg fat mass (right)	0.5	2.0	5.0	-2.2	-1.0	1.0	-2.0	0.8	0.7
Pulse rate, automated reading	0.5	1.5	4.6	-2.1	-1.3	1.3	-0.2	0.9	0.2
Comparative height size at age 10	0.5	3.0	9.8	-3.1	-0.9	1.2	-2.0	1.1	0.7
Had major operations	0.5	0.6	2.1	-0.7	-1.4	0.3	-0.5	-0.6	-0.4
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.2	0.6	0.2	-0.7	0.8	-1.1	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	2.2	-1.5	0.1	0.0	-0.8	0.5	0.3
Medication for cholesterol	0.5	0.7	1.7	-1.2	-0.3	0.6	-1.3	0.7	0.3
Asthma (self-reported)	0.5	1.0	3.1	0.7	1.8	0.3	1.6	-0.2	-0.0
Medication: Aspirin	0.5	0.7	2.3	1.5	0.2	0.0	0.8	-0.1	1.1
Ever depressed for a whole week	0.5	0.6	1.0	-1.0	0.1	1.0	-0.8	1.0	0.4
Leg fat mass (left)	0.5	1.9	5.0	-2.2	-1.1	0.7	-2.1	0.6	0.6
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	-1.2	-0.5	0.3	0.1	-0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	3.9	-2.0	-0.2	0.6	0.5	0.3	-1.1
Neuroticism (Nagel 2018)	0.4	1.0	4.3	-0.2	0.1	-0.1	-2.1	-0.1	1.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.0	-0.8	0.5	0.9	0.0	0.9
Respiratory disease	0.4	0.9	1.9	1.3	1.4	0.1	1.3	0.1	0.4
Neuroticism	0.4	1.0	2.9	0.9	-0.8	-0.9	-1.7	-0.9	0.4
Hand grip strength (left)	0.4	1.1	2.3	-0.7	0.3	-1.4	-0.7	-1.5	-1.1
Supplements: Zinc	0.4	0.4	1.1	0.7	0.3	-0.6	-0.5	-0.5	-1.0
Severe depression (siblings)	0.4	0.5	1.0	-0.2	-0.1	0.9	-0.4	0.8	1.0
Townsend deprivation index at recruitment	0.4	0.6	1.4	0.1	-0.9	-0.6	1.2	-0.6	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	2.0	0.5	0.1	-0.4	-1.4	-0.0	1.1
Relative age voice broke	0.4	0.7	1.3	1.0	1.0	1.1	0.1	0.6	0.4
Alcohol usually taken with meals	0.4	0.6	1.0	-1.0	-0.6	0.7	1.0	0.1	-0.8
Nervous feelings	0.4	0.7	1.6	-0.5	0.1	1.1	-0.8	0.5	1.3
Illnesses of siblings	0.4	0.5	2.4	0.1	1.6	0.0	-0.1	0.8	-0.3
Neuroticism score	0.4	0.9	3.3	0.5	0.2	-0.4	-1.8	-0.1	1.2
Pulse rate	0.4	0.7	1.6	-1.3	-0.2	1.1	-0.3	1.2	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.8	0.5	1.3	0.5	0.2	0.0	0.5
Headache pain in last month	0.4	0.7	1.4	0.0	-1.2	-0.5	0.2	-1.0	-1.1
Glaucoma (self-reported)	0.4	0.4	1.2	1.0	-0.0	-0.0	-0.4	0.4	1.1
Number of children fathered	0.4	0.5	1.4	0.2	-0.1	-1.1	-1.2	-0.3	-0.5
Medication: Blood pressure	0.4	0.7	1.8	-0.5	-1.3	0.5	-0.8	-0.3	-1.0
Migraine (self-reported)	0.4	0.5	1.5	0.1	-1.2	0.2	0.1	0.4	1.1
Medication: Allopurinol	0.4	0.5	1.3	-0.7	-1.1	0.1	-1.2	0.1	0.2
Knee pain experienced in last month	0.4	0.6	1.2	1.0	-0.3	-0.6	0.3	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.7	-0.0	-1.0	-1.2	-1.6	-0.4	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.6	-0.3	1.3	0.2	-0.6	1.0	-0.7
Back pain experienced in last month	0.4	0.6	1.8	-1.1	-0.3	0.3	-1.3	0.6	-0.2
Number of self-reported non-cancer illnesses	0.4	0.7	2.1	1.4	1.0	0.3	1.0	0.2	0.6
Wears glasses or contact lenses	0.4	0.4	1.4	0.3	1.1	0.1	1.2	-0.2	0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.7	-0.2	0.6	0.1	-0.7	0.1	-1.3
Worry (Nagel 2018)	0.3	0.7	1.2	0.6	-0.5	-0.6	-1.0	-1.1	0.9
Age at First Birth	0.3	0.5	0.9	-0.7	0.4	0.8	-0.7	1.0	0.5
Body Mass Index (BMI) (2010)	0.3	0.3	0.7	0.5	-0.5	-0.8	-0.4	-0.8	-0.3
HDL Cholesterol	0.3	0.6	1.1	0.5	1.0	0.9	0.7	1.0	0.2
Rheumatoid Arthritis	0.3	0.5	1.4	-1.2	0.3	0.5	-0.1	0.7	-0.8
Ulcerative Colitis	0.3	0.4	1.0	0.0	0.4	0.1	-1.0	0.9	0.8
Chronotype (morning person)	0.3	0.6	2.0	0.3	-1.4	-0.9	-0.2	-0.7	0.4
Frequency of depressed mood in last 2 weeks	0.3	0.4	1.1	-0.7	0.7	0.5	-1.0	0.2	0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.9	0.4	0.1	-0.9	0.6	0.1
Vitamin and mineral supplements	0.3	0.4	1.6	0.3	0.3	-0.5	0.0	0.7	1.3
Trunk fat percentage	0.3	1.2	3.3	-0.4	-0.0	1.1	-0.8	1.2	1.8
Hand grip strength (right)	0.3	0.9	2.4	-1.5	-0.3	-0.9	-0.5	-1.3	-0.7
Taking other prescription medications	0.3	0.5	1.4	1.0	-0.6	0.0	1.2	-0.1	0.4
Trunk fat mass	0.3	1.2	1.7	-1.3	-0.2	1.1	-1.2	1.1	1.2
Had other major operations	0.3	0.4	0.7	-0.5	0.0	0.4	-0.8	0.8	0.7
Weight	0.3	1.6	5.9	-2.4	-1.0	0.8	-1.4	0.5	-0.0
Falls in the last year	0.3	0.4	0.8	0.9	0.7	-0.4	-0.8	-0.4	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	0.9	0.8	-0.3	-0.9	-0.2	-0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.1	-0.2	-1.0	0.3	-0.6	0.7	0.4
Loud music exposure frequency	0.3	0.3	0.6	-0.4	0.1	0.7	-0.4	0.8	0.7
Medication: Paracetamol	0.3	0.5	1.2	-1.1	-0.9	0.0	-0.7	-0.2	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.3	0.2	0.8	-0.2	-0.4	-0.0	1.2
Health satisfaction	0.3	0.4	1.7	1.3	0.2	-0.6	-0.1	-0.4	0.0
Chest pain or discomfort	0.3	0.4	1.8	0.2	-0.3	-0.1	-1.3	0.1	-0.7
Whole body fat-free mass	0.3	2.0	7.2	-2.7	-0.9	-0.2	-1.5	-0.3	-1.2
Average weekly red wine intake	0.3	0.4	1.4	0.4	-0.1	-1.2	0.4	-0.9	-0.2
Qualifications: nursing, teaching	0.3	0.5	2.1	-0.5	-1.4	0.1	0.1	0.1	0.6
Whole body water mass	0.3	1.9	6.7	-2.6	-0.8	-0.3	-1.5	-0.4	-1.2
Miserableness	0.3	0.5	1.7	0.0	-0.9	-0.2	-1.3	-0.3	0.8
Basal metabolic rate	0.3	1.8	6.8	-2.6	-1.0	-0.0	-1.5	-0.1	-0.9
Average weekly beer plus cider intake	0.3	0.4	1.3	0.1	1.1	-0.5	-0.9	-0.6	0.1
Risk taking	0.3	0.4	1.1	0.5	0.8	-0.0	-1.0	-0.6	-0.0
Pain experienced in last month	0.3	0.6	1.8	-0.4	1.3	0.4	0.8	0.8	-0.1
Depression (Nagel 2018)	0.2	0.4	1.8	0.0	-0.1	-0.2	-1.3	-0.6	-0.0
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-0.3	1.0	0.6	-0.2	0.5	-0.1
Mean Putamen Volume	0.2	0.2	0.4	-0.5	0.1	0.5	0.1	0.7	0.4
Primary Biliary Cirrhosis	0.2	0.3	1.6	-0.1	1.3	-0.0	-0.4	-0.2	-0.1
Lung FEV1/FVC ratio	0.2	1.2	2.8	-1.6	-1.7	-0.7	-1.0	-0.0	-0.1
Medication: Co-codamol	0.2	0.2	0.5	0.4	-0.7	-0.6	0.1	-0.5	0.1
Fed-up feelings	0.2	0.3	1.0	0.5	0.4	-0.1	-0.2	0.4	1.0
Multivitamins +/- minerals	0.2	0.3	1.4	-0.4	-0.5	1.2	0.1	-0.2	-0.1
Waist circumference	0.2	0.7	2.2	-1.5	-0.6	1.1	-0.7	0.5	0.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.5	0.0	-0.1	-0.1	1.2	-0.4	-0.3
Medication: Ramipril	0.2	0.2	0.6	-0.1	0.7	0.8	0.2	-0.0	0.3
Arm fat percentage (right)	0.2	0.8	2.2	1.3	-0.2	-0.3	0.9	-0.2	1.5
Hair/balding pattern: Pattern 4	0.2	0.5	2.3	-0.4	-0.1	0.5	-0.3	0.6	1.5
Body fat percentage	0.2	0.9	1.7	-0.7	-0.4	1.1	-0.9	0.9	1.3
Shortness of breath walking on level ground	0.2	0.2	0.4	-0.0	0.4	0.6	0.4	0.6	-0.4
Medication for pain relief, constipation, heartburn	0.2	0.3	0.7	0.0	0.8	0.6	-0.0	0.8	0.2
Whole body fat mass	0.2	1.0	1.9	-1.4	-0.6	0.9	-1.2	0.8	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.1	0.3	0.7	0.5	0.6	-0.3
Arm fat percentage (left)	0.2	0.7	1.5	1.2	0.2	-0.1	1.0	-0.1	1.2
Unable to work because of sickness or disability	0.2	0.2	0.6	0.2	0.8	0.2	-0.3	-0.2	0.6
Supplements: Calcium	0.2	0.3	1.0	-0.0	0.3	0.4	-0.2	0.6	1.0
Neuroticism (2016)	0.1	0.2	0.6	-0.2	-0.0	0.4	-0.0	0.5	0.8
BMI	0.1	0.5	0.9	0.5	-0.7	-0.9	0.7	-0.7	0.7
Waist Hip Ratio (WHR)	0.1	0.4	0.9	0.8	-0.2	-0.6	0.6	-1.0	0.3
Cardiovascular Disease	0.1	0.3	0.9	-0.0	0.7	-0.1	0.1	-0.9	-0.7
Hypothyroidism (self reported)	0.1	0.2	0.5	0.3	-0.2	-0.1	0.7	-0.7	-0.1
Hair Pigment	0.1	2.2	4.3	1.8	-0.7	-1.6	0.2	-2.1	-1.7
Number of treatments/medications taken	0.1	0.1	0.3	0.2	0.3	0.4	-0.5	0.1	0.5
Systolic blood pressure, automated reading	0.1	0.4	1.0	-0.4	-1.0	0.2	0.9	0.1	0.7
Leg fat-free mass (left)	0.1	0.3	1.4	-1.2	-0.3	-0.5	-0.3	-0.2	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.4	-0.6	0.6	0.2	0.0	-0.2	-0.2
Medication: Levothyroxine sodium	0.1	0.2	0.7	-0.4	-0.3	0.7	0.8	0.3	0.1
Body mass index (BMI)	0.1	0.2	0.7	0.0	-0.2	-0.7	0.0	-0.9	-0.0
Leg predicted mass (left)	0.1	0.3	1.3	-1.2	-0.3	-0.6	-0.2	-0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.6	-0.5	0.8	0.4	0.4	-0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.5	0.5	-0.3	-0.1	-0.4	-0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.3	-0.3	0.1	0.3	0.5	0.0	0.5
Comparative body size at age 10	0.1	0.4	0.7	-0.2	0.6	-0.8	-0.8	-0.7	-0.5
Number of full brothers	0.1	0.1	0.3	0.5	0.5	0.2	-0.3	0.1	0.1
Leg fat-free mass (right)	0.1	0.4	1.1	-1.0	-0.2	-0.8	-0.2	-0.4	-0.5
Osteoarthritis (self-reported)	0.1	0.1	0.3	-0.1	-0.2	-0.2	-0.4	-0.6	0.5
Leg predicted mass (right)	0.1	0.4	1.1	-1.0	-0.2	-0.8	-0.2	-0.5	-0.5
Ever taken oral contraceptive pill	0.1	0.2	0.5	-0.7	-0.4	0.0	-0.3	0.4	0.2
Commuting to job workplace: Public transport	0.1	0.1	0.6	0.1	-0.8	0.0	-0.1	0.4	-0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Tanning	0.0	0.4	1.6	1.3	-0.2	-0.4	-0.4	-0.4	0.1
Arm fat mass (right)	0.0	0.2	0.7	0.0	-0.4	-0.3	-0.2	-0.2	0.9
Arm fat mass (left)	0.0	0.1	0.5	-0.2	-0.4	-0.1	-0.3	-0.2	0.7

Hub : Genes

CACFD1

Models

Trait associations