Hub : Genes

CACFD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1009 0.0431 9.5e-03 0.030 NA 0.024 NA 0.031 2.0e-03 NA 5.1e-03 NA 1.7e-03
2 GTEx Colon Transverse 0.1710 0.0680 9.7e-03 -0.005 NA -0.006 NA -0.006 7.1e-01 NA 8.2e-01 NA 9.0e-01
3 GTEx Esophagus Mucosa 0.2340 0.0570 6.2e-06 0.174 NA 0.191 NA 0.182 9.0e-12 NA 8.1e-13 NA 3.0e-12
4 GTEx Testis 0.2580 0.0790 2.4e-04 0.053 NA 0.095 NA 0.047 2.1e-03 NA 5.3e-05 NA 3.8e-03
5 GTEx Thyroid 0.2420 0.0520 3.2e-07 0.180 NA 0.132 NA 0.149 9.8e-14 NA 2.6e-10 NA 1.7e-11
6 METSIM Adipose 0.0691 0.0238 6.7e-04 0.001 0.009 -0.001 0.008 -0.001 2.2e-01 0.013 6.3e-01 0.017 4.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.4 0.6 1.5 -1.2 -1.2 -0.5 0.3 0.1 -0.4
Bipolar Disorder or Schizophrenia 0.4 1.0 3.9 -2.0 -0.2 0.6 0.5 0.3 -1.1
Depressed Affect (Nagel 2018) 0.5 1.1 2.3 0.8 0.3 -1.4 -1.5 -1.2 0.1
Depression (Nagel 2018) 0.2 0.4 1.8 0.0 -0.1 -0.2 -1.3 -0.6 -0.0
Intelligence (Savage-Jansen 2018) 0.6 1.8 5.4 -0.8 -0.9 2.3 -0.3 1.8 0.6
Neuroticism (Nagel 2018) 0.4 1.0 4.3 -0.2 0.1 -0.1 -2.1 -0.1 1.3
Schizophrenia (2018) 0.5 0.9 2.4 -1.5 0.7 1.1 0.5 0.3 -1.1
Schizophrenia vs Biploar Disorder 1.3 1.8 9.9 0.0 3.1 -0.3 0.3 -0.7 -0.3
Worry (Nagel 2018) 0.3 0.7 1.2 0.6 -0.5 -0.6 -1.0 -1.1 0.9
Alzheimer’s Disease (in mother) 0.8 0.9 1.7 -0.9 1.1 1.3 -0.0 1.3 0.4
Alzheimer’s Disease (in father) 1.1 1.2 5.2 0.8 -2.3 -0.4 -0.5 -0.8 0.2
Alzheimer’s Disease (including proxy) 0.2 0.3 1.1 -0.3 1.0 0.6 -0.2 0.5 -0.1
Crohns Disease (2017) 1.1 2.5 10.0 0.6 -0.8 0.8 -1.1 1.4 3.2
Irritable Bowel Disease (IBD) 1.3 3.0 8.5 0.0 -1.1 1.0 -2.0 1.9 2.9
Ulcerative Colitis (UC) 0.9 1.7 4.1 -0.4 -0.6 1.0 -2.0 1.8 1.2
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 1.3 2.4 6.2 0.7 -0.6 -2.5 0.8 -2.4 -1.0
Verbal and Numeric Reasoning (VNR) 1.7 4.1 7.7 -2.0 0.3 2.8 -2.2 2.1 1.9
Breast Cancer 1.7 4.1 14.3 -3.8 0.0 1.1 -2.9 0.3 -0.7
Ovarian Cancer 3.2 4.3 15.1 -2.9 -0.8 0.8 -3.9 0.5 -0.9
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.3 0.5 0.9 -0.7 0.4 0.8 -0.7 1.0 0.5
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.3 0.3 0.7 0.5 -0.5 -0.8 -0.4 -0.8 -0.3
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 1.6 2.5 5.7 -1.1 -1.2 1.6 -0.9 1.8 2.4
Mean Putamen Volume 0.2 0.2 0.4 -0.5 0.1 0.5 0.1 0.7 0.4
Fasting Glucose 0.9 1.0 2.4 -0.1 -1.6 1.0 0.4 1.4 0.8
HbA1C 1.7 1.9 3.9 1.3 0.5 0.4 2.0 1.5 1.7
HDL Cholesterol 0.3 0.6 1.1 0.5 1.0 0.9 0.7 1.0 0.2
LDL Cholesterol 7.3 11.6 30.6 5.5 1.3 -2.4 5.5 -0.6 0.8
Lupus 0.9 1.4 2.9 -0.3 1.2 -0.9 -1.3 -1.7 -1.1
Neuroticism (2016) 0.1 0.2 0.6 -0.2 -0.0 0.4 -0.0 0.5 0.8
Primary Biliary Cirrhosis 0.2 0.3 1.6 -0.1 1.3 -0.0 -0.4 -0.2 -0.1
Rheumatoid Arthritis 0.3 0.5 1.4 -1.2 0.3 0.5 -0.1 0.7 -0.8
Schizophrenia (2014) 1.1 2.3 8.2 -2.9 0.4 1.8 -0.2 0.9 -1.2
Triglycerides 2.0 3.3 5.3 0.3 -2.3 -1.9 1.4 -2.0 -2.1
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.8 0.0 -0.8 0.5 0.9 0.0 0.9
Ulcerative Colitis 0.3 0.4 1.0 0.0 0.4 0.1 -1.0 0.9 0.8
Blood Eosinophil Count 2.4 18.5 41.5 -6.4 0.9 5.2 -4.6 4.6 0.2
Blood Platelet Count 1.0 11.1 26.2 4.8 -2.6 -1.7 5.1 -1.8 -2.0
Blood Red Count 9.9 96.0 256.0 -16.0 -4.4 8.0 -14.5 5.0 -0.7
Blood White Count 2.5 18.5 47.9 -6.9 -0.9 3.5 -6.5 1.7 -2.2
Heel T-Score 1.6 12.9 31.6 -5.4 -2.8 2.0 -5.6 0.4 -2.2
BMI 0.1 0.5 0.9 0.5 -0.7 -0.9 0.7 -0.7 0.7
Height 0.9 17.6 48.4 -7.0 -2.5 4.2 -4.8 3.0 0.7
Waist Hip Ratio (WHR) 0.1 0.4 0.9 0.8 -0.2 -0.6 0.6 -1.0 0.3
Systolic Blood Pressure 0.6 3.1 7.1 0.0 -2.7 -1.2 1.3 -1.9 -2.3
Smoking Status 1.2 2.8 14.0 -0.4 3.7 0.7 -1.3 0.3 -0.5
Allergy or Eczema 1.0 2.5 5.4 -0.1 0.5 2.1 2.3 2.2 -0.1
Cardiovascular Disease 0.1 0.3 0.9 -0.0 0.7 -0.1 0.1 -0.9 -0.7
Hypothyroidism (self reported) 0.1 0.2 0.5 0.3 -0.2 -0.1 0.7 -0.7 -0.1
Respiratory disease 0.4 0.9 1.9 1.3 1.4 0.1 1.3 0.1 0.4
Type 2 Diabetes (T2D) (2018) 0.7 1.4 4.1 2.0 -1.3 -0.8 0.3 -1.1 0.8
Lung FEV1/FVC ratio 0.2 1.2 2.8 -1.6 -1.7 -0.7 -1.0 -0.0 -0.1
Lung FVC 2.0 10.3 27.6 -5.2 0.9 3.0 -4.3 2.3 -0.4
Neuroticism 0.4 1.0 2.9 0.9 -0.8 -0.9 -1.7 -0.9 0.4
Chronotype (morning person) 0.3 0.6 2.0 0.3 -1.4 -0.9 -0.2 -0.7 0.4
Hair Pigment 0.1 2.2 4.3 1.8 -0.7 -1.6 0.2 -2.1 -1.7
Tanning 0.0 0.4 1.6 1.3 -0.2 -0.4 -0.4 -0.4 0.1
Hand grip strength (left) 0.4 1.1 2.3 -0.7 0.3 -1.4 -0.7 -1.5 -1.1
Number of treatments/medications taken 0.1 0.1 0.3 0.2 0.3 0.4 -0.5 0.1 0.5
Average weekly spirits intake 2.0 2.5 7.9 2.8 0.3 -1.8 1.8 -0.7 0.1
Sensitivity / hurt feelings 2.9 5.0 8.2 -1.9 0.0 2.1 -2.9 2.4 2.8
Frequency of depressed mood in last 2 weeks 0.3 0.4 1.1 -0.7 0.7 0.5 -1.0 0.2 0.1
Hearing difficulty/problems: Yes 3.1 4.7 10.6 -1.4 2.0 2.0 -1.3 2.4 3.2
Relative age of first facial hair 0.5 1.1 3.4 -1.2 0.7 1.9 0.0 1.1 -0.4
Other serious medical condition/disability diagnosed by doctor 1.3 1.6 2.9 -0.9 1.6 1.4 -0.6 1.7 1.1
Ever used hormone-replacement therapy (HRT) 3.2 4.1 8.8 1.8 -1.4 -2.7 1.9 -3.0 -0.0
Ever had hysterectomy (womb removed) 0.9 1.0 2.0 1.3 -0.9 -0.6 0.8 -1.4 0.8
Systolic blood pressure, automated reading 0.1 0.4 1.0 -0.4 -1.0 0.2 0.9 0.1 0.7
Eye problems/disorders: Diabetes related eye disease 0.3 0.4 0.8 0.9 0.4 0.1 -0.9 0.6 0.1
Angina 3.3 4.3 9.1 -2.7 1.0 3.0 -1.6 2.0 1.4
Medication for hormone replacement therapy 0.7 0.8 1.7 0.8 -0.9 -1.1 1.3 -0.2 -0.7
Vitamin and mineral supplements 0.3 0.4 1.6 0.3 0.3 -0.5 0.0 0.7 1.3
Supplements: Zinc 0.4 0.4 1.1 0.7 0.3 -0.6 -0.5 -0.5 -1.0
Medication: Co-codamol 0.2 0.2 0.5 0.4 -0.7 -0.6 0.1 -0.5 0.1
Medication: Metformin 1.5 2.1 4.3 2.1 -0.0 -0.9 1.9 -1.1 1.7
Diabetes (father) 0.8 1.0 3.5 -0.3 0.3 0.1 -1.4 0.6 1.9
Diabetes (mother) 0.9 1.2 2.9 1.7 -0.1 -1.5 -0.0 -0.9 1.1
Severe depression (siblings) 0.4 0.5 1.0 -0.2 -0.1 0.9 -0.4 0.8 1.0
Pack years adult smoking proportion 1.5 2.3 5.3 1.7 1.9 -0.2 2.3 -1.1 0.9
Impedance of leg (right) 1.5 7.3 13.2 -3.0 -1.5 3.6 -3.0 2.9 1.3
Leg fat-free mass (left) 0.1 0.3 1.4 -1.2 -0.3 -0.5 -0.3 -0.2 -0.1
Trunk fat percentage 0.3 1.2 3.3 -0.4 -0.0 1.1 -0.8 1.2 1.8
Hand grip strength (right) 0.3 0.9 2.4 -1.5 -0.3 -0.9 -0.5 -1.3 -0.7
Townsend deprivation index at recruitment 0.4 0.6 1.4 0.1 -0.9 -0.6 1.2 -0.6 -0.7
Current tobacco smoking 1.2 1.9 7.3 1.5 2.7 -0.6 0.9 -0.8 -0.6
Average weekly fortified wine intake 1.4 1.7 8.1 0.3 -1.0 0.2 0.0 0.9 2.8
Maternal smoking around birth 0.5 0.8 1.6 0.9 1.2 -0.1 1.2 -0.9 0.2
Fed-up feelings 0.2 0.3 1.0 0.5 0.4 -0.1 -0.2 0.4 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 2.0 0.5 0.1 -0.4 -1.4 -0.0 1.1
Relative age voice broke 0.4 0.7 1.3 1.0 1.0 1.1 0.1 0.6 0.4
Taking other prescription medications 0.3 0.5 1.4 1.0 -0.6 0.0 1.2 -0.1 0.4
Age when periods started (menarche) 0.5 1.3 2.9 0.3 0.8 1.1 0.0 1.7 1.7
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 3.3 1.7 0.4 -1.5 1.8 -1.1 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 5.2 -1.2 -0.9 -0.3 -0.5 -1.2 -2.3
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.2 1.6 -0.3 -0.2 2.0 -0.3 0.2
Qualifications: CSEs or equivalent 3.7 4.8 11.4 3.0 0.4 -3.4 1.2 -2.5 -0.9
Serious illness, injury or assault to yourself 0.6 0.8 1.9 1.4 0.3 -1.2 0.2 -0.7 0.6
High blood pressure 0.8 2.3 5.2 -1.9 0.2 0.1 -2.0 -1.0 -2.3
Hayfever, allergic rhinitis or eczema 0.7 1.5 4.6 0.4 1.1 1.2 2.2 1.3 -0.0
Multivitamins +/- minerals 0.2 0.3 1.4 -0.4 -0.5 1.2 0.1 -0.2 -0.1
Stomach or abdominal pain in last month 0.7 0.9 1.7 1.1 -0.7 -1.3 0.3 -1.2 -0.5
Supplements: Glucosamine 1.6 2.0 4.5 -1.6 -1.2 2.1 -1.3 1.2 0.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.4 -0.6 0.6 0.2 0.0 -0.2 -0.2
Medication: Atenolol 0.8 1.0 4.8 -0.4 0.9 0.3 0.2 -0.1 -2.2
Medication: Levothyroxine sodium 0.1 0.2 0.7 -0.4 -0.3 0.7 0.8 0.3 0.1
Sitting height 1.8 12.5 32.9 -5.7 -3.4 2.8 -4.2 2.2 0.4
Chronic bronchitis/emphysema (father) 1.2 1.4 2.7 -0.3 -1.6 1.3 -1.2 1.6 0.4
High blood pressure (mother) 2.3 3.3 5.4 1.7 -1.8 -2.3 0.7 -2.3 -1.6
Body mass index (BMI) 0.1 0.2 0.7 0.0 -0.2 -0.7 0.0 -0.9 -0.0
Impedance of leg (left) 1.6 7.7 12.2 -3.3 -1.6 3.5 -3.5 2.7 1.0
Leg predicted mass (left) 0.1 0.3 1.3 -1.2 -0.3 -0.6 -0.2 -0.2 -0.2
Trunk fat mass 0.3 1.2 1.7 -1.3 -0.2 1.1 -1.2 1.1 1.2
Waist circumference 0.2 0.7 2.2 -1.5 -0.6 1.1 -0.7 0.5 0.1
Number of incorrect matches in round 0.5 0.7 2.1 -0.6 0.3 1.5 1.1 0.9 0.1
Past tobacco smoking 1.6 2.9 8.3 1.6 -2.9 -1.7 1.3 -1.4 -0.6
Alcohol usually taken with meals 0.4 0.6 1.0 -1.0 -0.6 0.7 1.0 0.1 -0.8
Nervous feelings 0.4 0.7 1.6 -0.5 0.1 1.1 -0.8 0.5 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.5 1.6 -0.5 -1.5 -0.3 -1.3 -0.8
Hearing difficulty/problems with background noise 2.3 3.7 6.8 -2.0 0.9 2.6 -1.5 2.4 1.5
Hair/balding pattern: Pattern 2 0.6 0.8 2.4 -1.6 0.2 0.4 -1.4 0.1 -0.2
Had menopause 0.7 0.9 3.6 0.4 -0.8 0.0 1.9 -0.3 -0.8
Had other major operations 0.3 0.4 0.7 -0.5 0.0 0.4 -0.8 0.8 0.7
Forced vital capacity (FVC) 3.0 11.5 31.4 -5.1 -1.0 2.3 -5.6 2.3 0.6
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.2 9.0 -0.9 -1.5 -0.1 -0.0 -1.2 -3.0
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 1.5 0.0 -0.1 -0.1 1.2 -0.4 -0.3
Qualifications: None of the above 0.6 1.3 3.4 1.8 0.8 -1.1 1.0 -1.2 -0.5
Financial difficulties in last 2 years 0.7 1.0 3.1 -1.2 1.0 0.2 -1.8 -0.2 -0.6
Mouth/teeth dental problems 0.8 1.2 3.2 -1.4 -1.3 -0.0 -0.2 -0.5 -1.8
Heart attack 0.6 0.8 2.4 1.2 -0.2 -0.7 1.6 -0.7 0.1
Allergy 2.0 4.7 13.0 -3.1 -1.4 -0.5 -3.6 -1.1 -1.5
Pain all over the body in last month 1.3 1.4 3.3 0.4 1.8 -0.7 -1.7 -1.1 -0.3
Diabetes (self-reported) 0.6 1.0 3.7 1.3 -0.1 0.3 0.2 0.4 1.9
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.5 1.2 1.5 0.2 2.1 1.0 0.4
Medication: Ramipril 0.2 0.2 0.6 -0.1 0.7 0.8 0.2 -0.0 0.3
Medication: Simvastatin 1.2 1.8 5.1 1.8 1.4 0.4 0.3 0.7 2.3
Fluid intelligence score 1.6 3.3 5.9 -2.4 -0.6 2.4 -1.9 1.5 1.3
Illnesses of siblings 0.4 0.5 2.4 0.1 1.6 0.0 -0.1 0.8 -0.3
Neuroticism score 0.4 0.9 3.3 0.5 0.2 -0.4 -1.8 -0.1 1.2
Weight 0.3 1.6 5.9 -2.4 -1.0 0.8 -1.4 0.5 -0.0
Impedance of arm (right) 1.0 4.7 11.1 1.6 -0.5 2.3 1.6 2.5 3.3
Arm fat percentage (right) 0.2 0.8 2.2 1.3 -0.2 -0.3 0.9 -0.2 1.5
Trunk fat-free mass 0.6 3.4 11.2 -3.3 -1.4 0.1 -2.0 -0.3 -1.7
Hip circumference 0.5 2.0 5.5 -2.3 -0.8 1.6 -1.0 1.4 0.1
Time employed in main current job 1.2 1.4 4.4 0.9 -0.7 -1.2 0.6 -0.9 -2.1
Alcohol intake versus 10 years previously 1.0 1.5 3.9 0.8 0.3 -1.6 -1.3 -2.0 -0.7
Father’s age at death 3.0 4.1 10.2 -3.2 -0.1 2.3 -2.2 2.0 -0.4
Worrier / anxious feelings 0.6 1.1 2.4 -1.3 -0.4 1.5 -1.1 0.7 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.8 1.2 3.1 1.8 -0.3 -1.3 -0.6 -1.5 -0.2
Falls in the last year 0.3 0.4 0.8 0.9 0.7 -0.4 -0.8 -0.4 0.4
Hair/balding pattern: Pattern 3 0.5 0.7 2.8 0.7 -0.7 -0.0 1.7 -0.6 -0.2
Number of live births 1.0 1.4 3.8 -0.8 2.0 -0.2 -0.5 -0.9 -1.7
Forced expiratory volume in 1-second (FEV1) 3.1 10.6 30.5 -4.9 -2.0 1.5 -5.5 1.7 0.5
Pulse rate 0.4 0.7 1.6 -1.3 -0.2 1.1 -0.3 1.2 0.4
Happiness 1.2 1.5 2.8 -1.4 -1.4 1.7 -0.1 1.4 0.6
Noisy workplace 0.5 0.6 1.8 0.3 0.7 -1.3 -0.6 -0.9 -0.4
Qualifications: A levels/AS levels or equivalent 1.2 2.7 6.6 -2.2 1.1 2.6 -0.8 1.7 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 0.9 0.8 -0.3 -0.9 -0.2 -0.7 0.1
Mouth/teeth dental problems: Dentures 0.8 1.4 4.1 2.0 -0.0 -0.7 1.1 -1.0 1.2
Asthma 0.5 1.0 3.3 0.8 1.8 0.3 1.5 -0.2 -0.2
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 1.1 -0.2 -1.0 0.3 -0.6 0.7 0.4
Medication: Cholesterol lowering 1.3 2.0 7.1 2.7 0.5 -1.0 1.6 -0.0 0.9
Depression (self-reported) 0.7 0.9 2.4 -1.6 0.5 0.8 -0.7 0.8 0.8
Medication: Lansoprazole 0.9 1.0 5.5 -0.1 2.3 0.7 0.0 -0.0 0.0
Prospective memory result 0.9 1.2 3.0 1.7 -0.0 -1.0 1.4 -0.9 -0.4
Lung cancer (father) 2.0 2.4 4.5 -1.9 0.0 1.7 -1.0 1.5 2.1
Illnesses of mother 0.9 1.1 1.9 -1.4 1.3 1.3 -0.2 1.0 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 3.6 11.4 29.7 -5.5 -2.1 1.9 -5.1 2.1 -0.0
Pulse wave Arterial Stiffness index 3.3 3.9 8.4 -2.9 -0.4 2.1 -1.9 2.2 1.2
Impedance of arm (left) 0.8 3.8 7.0 1.8 -0.3 2.0 1.9 2.3 2.7
Arm fat mass (right) 0.0 0.2 0.7 0.0 -0.4 -0.3 -0.2 -0.2 0.9
Trunk predicted mass 0.6 3.4 11.2 -3.3 -1.6 0.2 -2.0 -0.2 -1.6
Standing height 1.0 10.0 28.5 -5.3 -2.0 3.2 -3.2 2.7 0.2
Length of working week for main job 3.8 4.2 7.1 2.7 -0.1 -2.2 2.3 -2.1 -1.8
Exposure to tobacco smoke at home 1.0 1.2 3.9 1.1 2.0 -0.6 0.1 -0.3 1.1
Breastfed as a baby 0.5 0.6 1.6 -1.3 -1.1 0.7 -0.1 0.6 0.3
Tense / ‘highly strung’ 0.8 1.4 3.5 -0.3 0.9 0.9 -1.9 0.7 1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.6 -0.5 0.8 0.4 0.4 -0.1 -0.2
Hair/balding pattern: Pattern 4 0.2 0.5 2.3 -0.4 -0.1 0.5 -0.3 0.6 1.5
Birth weight of first child 1.6 3.0 5.3 -2.3 -0.6 2.0 -0.8 2.2 1.6
Peak expiratory flow (PEF) 5.1 11.8 31.2 -5.6 -1.5 2.7 -5.1 1.9 0.5
Pulse wave reflection index 2.4 3.0 5.5 -2.3 2.0 2.0 -1.5 1.2 0.7
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.8 0.5 1.3 0.5 0.2 0.0 0.5
Loud music exposure frequency 0.3 0.3 0.6 -0.4 0.1 0.7 -0.4 0.8 0.7
Qualifications: O levels/GCSEs or equivalent 1.1 1.7 4.0 -1.9 2.0 0.9 -0.9 1.1 -0.2
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.8 0.3 0.6 0.8 -0.8 1.4 1.9
Blood clot in the leg (DVT) 16.4 21.2 60.6 7.8 2.9 -1.4 6.4 -0.5 3.9
Medication: Paracetamol 0.3 0.5 1.2 -1.1 -0.9 0.0 -0.7 -0.2 -0.7
Headache pain in last month 0.4 0.7 1.4 0.0 -1.2 -0.5 0.2 -1.0 -1.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.1 0.2 -0.5 0.5 -0.3 -0.1 -0.4 -0.2
Glaucoma (self-reported) 0.4 0.4 1.2 1.0 -0.0 -0.0 -0.4 0.4 1.1
Gout (self-reported) 0.5 0.6 2.2 -0.4 -1.1 -0.3 0.1 -0.4 -1.5
Hypothyroidism/myxoedema (self-reported) 0.1 0.1 0.3 -0.3 0.1 0.3 0.5 0.0 0.5
Medication: Amlodipine 0.6 0.8 2.5 0.2 -0.5 -0.7 0.3 -1.2 -1.6
Medication: Ventolin 100micrograms inhaler 1.1 1.4 4.7 0.5 2.2 0.7 -0.0 1.4 1.0
Birth weight 0.7 1.5 4.8 0.5 0.9 0.4 0.7 2.2 1.5
Chronic bronchitis/emphysema (mother) 0.8 0.9 2.4 0.4 1.6 -1.0 -0.4 -1.3 0.3
High blood pressure (siblings) 0.7 1.0 3.1 -0.5 -1.8 -0.4 -1.2 -1.0 -0.3
Forced vital capacity (FVC), Best measure 3.3 12.2 31.4 -5.6 -1.5 2.6 -5.1 2.6 -0.0
Body fat percentage 0.2 0.9 1.7 -0.7 -0.4 1.1 -0.9 0.9 1.3
Leg fat percentage (right) 0.7 2.6 5.7 -2.4 -1.1 1.8 -2.0 1.0 0.6
Arm fat-free mass (right) 0.7 3.8 12.7 -3.6 -0.6 0.1 -2.7 -0.2 -1.5
Exposure to tobacco smoke outside home 0.8 1.1 3.1 0.5 -0.1 -1.4 -0.9 -1.8 0.6
Comparative body size at age 10 0.1 0.4 0.7 -0.2 0.6 -0.8 -0.8 -0.7 -0.5
Number of full brothers 0.1 0.1 0.3 0.5 0.5 0.2 -0.3 0.1 0.1
Worry too long after embarrassment 0.8 1.3 4.5 -0.6 0.4 0.2 -1.4 1.0 2.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.3 0.2 0.8 -0.2 -0.4 -0.0 1.2
Wheeze or whistling in the chest in last year 1.3 2.3 5.4 2.3 1.7 -1.7 1.3 -0.9 0.5
Number of children fathered 0.4 0.5 1.4 0.2 -0.1 -1.1 -1.2 -0.3 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.2 1.5 4.8 2.2 -1.1 -1.1 -0.2 -1.0 0.7
Age at first live birth 2.7 4.8 12.4 -2.7 -1.8 1.8 -3.5 1.7 0.1
Pulse wave peak to peak time 2.8 3.3 6.1 2.5 0.0 -2.0 1.8 -2.2 -1.4
Health satisfaction 0.3 0.4 1.7 1.3 0.2 -0.6 -0.1 -0.4 0.0
Shortness of breath walking on level ground 0.2 0.2 0.4 -0.0 0.4 0.6 0.4 0.6 -0.4
Qualifications: College or University degree 1.9 6.1 16.6 -4.1 -0.8 3.2 -0.5 2.9 0.7
Eye problems/disorders: None of the above 2.6 3.0 6.5 0.2 -0.5 -2.2 0.6 -2.5 -2.6
Mouth/teeth dental problems: Loose teeth 0.8 1.0 4.7 0.9 2.2 -0.3 -0.2 0.4 0.5
Emphysema/chronic bronchitis 1.8 2.0 6.4 1.7 2.5 -0.8 0.9 -1.0 -0.4
Medication for pain relief, constipation, heartburn 0.2 0.3 0.7 0.0 0.8 0.6 -0.0 0.8 0.2
Neck or shoulder pain in last month 0.5 0.7 3.2 0.5 -0.1 -0.6 -0.3 -0.1 1.8
Medication: Blood pressure 0.4 0.7 1.8 -0.5 -1.3 0.5 -0.8 -0.3 -1.0
Angina (self-reported) 3.2 4.1 8.1 -2.6 1.1 2.8 -1.9 1.8 1.4
Migraine (self-reported) 0.4 0.5 1.5 0.1 -1.2 0.2 0.1 0.4 1.1
Medication: Ibuprofen 1.1 1.3 2.5 -0.5 -1.2 0.9 -0.9 1.5 1.6
Medication: Allopurinol 0.4 0.5 1.3 -0.7 -1.1 0.1 -1.2 0.1 0.2
Medication: Omeprazole 1.4 1.7 8.2 0.1 -0.6 -0.6 0.1 -1.1 -2.9
Medication: Seretide 50 evohaler 1.2 1.3 5.9 1.1 0.3 -0.1 2.4 -0.8 0.4
Mean time to correctly identify matches 1.0 2.0 4.1 0.2 -1.7 -1.9 0.6 -2.0 -0.9
Heart disease (mother) 1.3 1.6 4.7 1.5 0.6 -0.8 2.2 -1.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.3 1.5 2.8 0.9 -1.5 -1.7 -0.5 -1.5 -0.8
Whole body fat mass 0.2 1.0 1.9 -1.4 -0.6 0.9 -1.2 0.8 1.0
Leg fat mass (right) 0.5 2.0 5.0 -2.2 -1.0 1.0 -2.0 0.8 0.7
Arm predicted mass (right) 0.8 4.0 13.7 -3.7 -0.7 0.2 -2.9 0.1 -1.4
Pulse rate, automated reading 0.5 1.5 4.6 -2.1 -1.3 1.3 -0.2 0.9 0.2
Alcohol intake frequency. 0.7 1.6 3.6 -1.6 -1.6 0.8 -1.9 0.4 -0.2
Comparative height size at age 10 0.5 3.0 9.8 -3.1 -0.9 1.2 -2.0 1.1 0.7
Number of full sisters 1.5 1.9 5.7 0.7 -0.6 -2.1 0.0 -2.4 -0.2
Suffer from ‘nerves’ 0.6 0.9 2.2 0.8 -0.2 -1.0 -0.8 -1.5 0.9
Overall health rating 0.6 1.2 3.4 1.8 0.5 -1.3 0.5 -1.3 -0.5
Chest pain or discomfort 0.3 0.4 1.8 0.2 -0.3 -0.1 -1.3 0.1 -0.7
Had major operations 0.5 0.6 2.1 -0.7 -1.4 0.3 -0.5 -0.6 -0.4
Age at last live birth 2.8 4.0 10.8 -2.9 -0.6 1.8 -3.3 1.2 -0.1
Family relationship satisfaction 0.6 0.8 2.4 -0.6 -0.8 1.6 0.0 0.8 0.8
Leg pain on walking 2.1 2.6 7.3 2.7 -1.0 -2.3 -0.0 -1.4 0.5
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.8 5.8 2.1 -0.2 -2.4 1.5 -1.9 0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.2 0.6 0.2 -0.7 0.8 -1.1 -0.8
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.6 -1.6 -1.2 1.6 -0.1 1.6 0.1
Medication: Aspirin 0.7 0.9 2.5 1.6 -0.2 -0.1 1.3 -0.2 1.1
Supplements: Vitamin C 1.2 1.5 3.9 0.8 -0.6 -0.9 0.1 -1.8 -2.0
Knee pain experienced in last month 0.4 0.6 1.2 1.0 -0.3 -0.6 0.3 -1.0 -1.1
Hypertension (Self-reported) 0.7 2.0 3.7 -1.8 0.5 0.3 -1.9 -0.9 -1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 0.1 0.3 0.7 0.5 0.6 -0.3
Illnesses of father: Heart disease 0.8 1.1 2.1 1.2 -0.2 0.7 0.7 1.4 1.4
Illnesses of siblings: Diabetes 1.4 1.7 6.0 -0.7 -1.7 0.6 -0.5 0.4 2.5
Smoking status: Previous 1.8 2.7 3.8 -2.0 1.7 1.7 -1.7 1.8 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.7 -0.0 -1.0 -1.2 -1.6 -0.4 -0.4
Whole body fat-free mass 0.3 2.0 7.2 -2.7 -0.9 -0.2 -1.5 -0.3 -1.2
Leg fat-free mass (right) 0.1 0.4 1.1 -1.0 -0.2 -0.8 -0.2 -0.4 -0.5
Arm fat percentage (left) 0.2 0.7 1.5 1.2 0.2 -0.1 1.0 -0.1 1.2
Average weekly red wine intake 0.3 0.4 1.4 0.4 -0.1 -1.2 0.4 -0.9 -0.2
Handedness (chirality/laterality): Left-handed 2.1 2.5 7.1 1.7 -0.7 -0.7 2.7 -1.7 -1.1
Mood swings 0.9 1.7 6.7 -1.0 1.3 0.4 -2.6 0.4 0.5
Loneliness, isolation 1.0 1.4 2.9 1.7 -1.7 -1.5 0.6 -0.7 -0.3
Long-standing illness, disability or infirmity 1.9 2.8 10.1 -0.9 0.3 1.2 -1.5 1.5 3.2
Ever had bowel cancer screening 0.8 0.9 1.7 -0.8 0.6 1.1 -1.1 1.3 -0.5
Diabetes diagnosed by doctor 0.6 1.0 2.8 1.7 0.5 -0.1 0.7 -0.2 1.5
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 2.2 -1.5 0.1 0.0 -0.8 0.5 0.3
Friendships satisfaction 0.9 1.2 3.8 -0.6 -2.0 1.2 0.3 1.1 0.5
Qualifications: nursing, teaching 0.3 0.5 2.1 -0.5 -1.4 0.1 0.1 0.1 0.6
Commuting to job workplace: Walk 1.3 1.4 4.2 -1.2 0.4 0.8 -2.0 0.6 1.2
Eye problems/disorders: Cataract 1.5 1.7 5.3 -0.2 -0.1 1.4 -0.2 1.6 2.3
Mouth/teeth dental problems: Mouth ulcers 0.4 0.6 1.6 -0.3 1.3 0.2 -0.6 1.0 -0.7
Medication for cholesterol 0.5 0.7 1.7 -1.2 -0.3 0.6 -1.3 0.7 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.0 -1.4 -0.1 1.4 -0.9 0.9 0.1
Back pain experienced in last month 0.4 0.6 1.8 -1.1 -0.3 0.3 -1.3 0.6 -0.2
Mineral and other dietary supplements 0.6 0.8 1.7 1.0 0.8 -1.3 1.0 -0.4 0.2
Breast cancer (self-reported) 0.7 0.8 3.1 1.3 0.1 -0.3 1.8 -0.1 -0.2
Asthma (self-reported) 0.5 1.0 3.1 0.7 1.8 0.3 1.6 -0.2 -0.0
Osteoporosis (self-reported) 1.1 1.4 2.9 -0.3 0.5 1.6 0.7 1.7 1.4
Osteoarthritis (self-reported) 0.1 0.1 0.3 -0.1 -0.2 -0.2 -0.4 -0.6 0.5
Medication: Aspirin 0.5 0.7 2.3 1.5 0.2 0.0 0.8 -0.1 1.1
Medication: Gliclazide 1.0 1.1 2.5 1.6 -0.1 -1.2 0.9 -1.0 -0.9
Illnesses of father: None of the above (group 1) 0.9 1.2 3.4 -0.2 -0.5 -0.8 1.6 -0.5 -1.8
Smoking status: Current 1.1 1.8 7.2 1.3 2.7 -0.7 0.5 -0.9 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.3 8.5 -2.9 -1.8 0.3 -2.8 0.1 0.1
Whole body water mass 0.3 1.9 6.7 -2.6 -0.8 -0.3 -1.5 -0.4 -1.2
Leg predicted mass (right) 0.1 0.4 1.1 -1.0 -0.2 -0.8 -0.2 -0.5 -0.5
Arm fat mass (left) 0.0 0.1 0.5 -0.2 -0.4 -0.1 -0.3 -0.2 0.7
Number of self-reported non-cancer illnesses 0.4 0.7 2.1 1.4 1.0 0.3 1.0 0.2 0.6
Average weekly champagne plus white wine intake 0.9 1.2 2.9 -1.4 -0.4 1.3 -0.0 1.7 0.5
Miserableness 0.3 0.5 1.7 0.0 -0.9 -0.2 -1.3 -0.3 0.8
Guilty feelings 0.7 1.1 2.5 -0.9 -0.7 0.5 -0.7 1.4 1.6
Wears glasses or contact lenses 0.4 0.4 1.4 0.3 1.1 0.1 1.2 -0.2 0.1
Ever taken oral contraceptive pill 0.1 0.2 0.5 -0.7 -0.4 0.0 -0.3 0.4 0.2
Hearing aid user 2.0 2.3 7.4 1.0 2.7 0.3 -0.3 1.0 2.0
Mother’s age at death 1.3 1.7 4.5 -2.1 0.4 0.9 -1.7 1.2 -0.4
Financial situation satisfaction 0.6 0.8 1.7 0.5 -0.3 -1.1 0.2 -1.2 -1.3
Tinnitus: Yes, now most or all of the time 3.1 3.6 8.9 -3.0 1.3 1.7 -2.7 0.9 0.3
Commuting to job workplace: Public transport 0.1 0.1 0.6 0.1 -0.8 0.0 -0.1 0.4 -0.2
Eye problems/disorders: Glaucoma 1.0 1.2 3.7 0.3 0.6 0.9 -1.1 0.9 1.9
Medication: Blood pressure 1.0 2.0 4.7 -0.7 1.6 -0.5 -0.1 -1.9 -2.2
Pain type(s) experienced in last month: Hip pain 0.7 0.9 2.8 -1.4 -0.1 0.1 -1.7 0.3 0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.1 -0.5 -1.8 0.0 -0.2 -0.9 -0.8
High cholesterol (Self-reported) 2.2 3.9 11.4 3.0 1.0 -0.1 3.4 0.5 1.2
Medication: Bendroflumethiazide 1.8 2.7 7.9 0.7 -0.6 -1.4 1.1 -2.0 -2.8
Medication: Paracetamol 0.7 1.2 2.7 -1.6 -0.5 1.2 -1.2 1.1 0.0
Medication: Lisinopril 1.0 1.2 3.3 -1.8 -0.2 1.1 -1.2 1.0 -0.7
Medication: Atorvastatin 1.8 2.2 6.2 2.1 0.9 -0.5 2.5 -0.3 1.3
Illnesses of father: High blood pressure 1.8 2.2 5.2 -1.7 1.2 1.0 -2.3 0.8 1.4
Alcohol drinker status: Never 1.1 1.4 4.9 -1.2 0.8 0.5 -2.2 -0.1 1.0
Ever smoked 0.6 1.0 5.6 0.3 2.4 0.1 -0.2 -0.1 -0.5
Basal metabolic rate 0.3 1.8 6.8 -2.6 -1.0 -0.0 -1.5 -0.1 -0.9
Leg fat percentage (left) 0.6 2.3 5.7 -2.4 -1.2 1.5 -1.9 0.7 0.3
Arm fat-free mass (left) 0.7 3.5 11.5 -3.4 -1.2 0.1 -2.6 -0.3 -1.2
Number of operations (self-reported) 0.9 1.4 3.6 1.9 -1.1 -1.2 1.1 -0.9 0.2
Average weekly beer plus cider intake 0.3 0.4 1.3 0.1 1.1 -0.5 -0.9 -0.6 0.1
Irritability 1.7 2.9 6.4 -1.0 1.4 1.5 -2.5 2.1 1.4
Risk taking 0.3 0.4 1.1 0.5 0.8 -0.0 -1.0 -0.6 -0.0
Ever had prostate specific antigen (PSA) test 0.4 0.5 1.7 -0.2 0.6 0.1 -0.7 0.1 -1.3
Fractured/broken bones in last 5 years 0.8 1.0 3.0 -0.4 1.7 1.2 0.4 0.9 0.7
Age started oral contraceptive pill 1.0 1.2 2.6 -1.2 -1.2 1.6 0.5 1.2 0.1
Diastolic blood pressure, automated reading 0.9 2.8 8.5 -2.9 -1.1 -0.2 -2.4 -0.8 -0.9
Ever depressed for a whole week 0.5 0.6 1.0 -1.0 0.1 1.0 -0.8 1.0 0.4
Unable to work because of sickness or disability 0.2 0.2 0.6 0.2 0.8 0.2 -0.3 -0.2 0.6
Commuting to job workplace: Cycle 1.7 2.1 3.1 -1.8 -1.2 1.5 -0.8 1.6 1.5
Myopia 0.9 1.3 6.2 -0.3 1.1 -0.5 -2.5 -0.0 0.1
Vascular/heart problems diagnosed by doctor 0.7 1.9 3.5 1.9 -0.4 -0.5 1.8 1.0 1.9
Cholesterol lowering medication 1.4 2.0 4.7 1.9 0.6 0.7 2.2 0.6 1.6
Medication: Omeprazole (e.g. Zanprol) 1.2 1.4 7.1 0.4 -0.3 -0.7 0.2 -0.8 -2.7
Pain experienced in last month 0.3 0.6 1.8 -0.4 1.3 0.4 0.8 0.8 -0.1
Supplements: Calcium 0.2 0.3 1.0 -0.0 0.3 0.4 -0.2 0.6 1.0
Basal cell carcinoma (self-reported) 1.2 1.4 3.5 -0.4 0.4 0.7 -1.9 1.0 1.8
Heart attack/myocardial infarction (self-reported) 0.8 1.1 3.5 1.4 0.0 -0.7 1.9 -0.7 0.1
Deep venous thrombosis (DVT) (self-reported) 15.9 20.4 55.7 7.5 2.6 -1.4 6.5 -0.5 4.0
Heart disease (siblings) 0.7 0.8 2.6 0.3 -0.5 1.0 1.6 0.6 0.8
Alcohol drinker status: Previous 0.7 0.8 2.9 -0.6 -0.4 0.4 -1.7 0.8 0.7
Pack years of smoking 1.1 1.6 3.1 1.0 1.6 0.5 1.8 -0.4 1.6
Impedance of whole body 0.7 3.7 8.7 -0.5 -0.6 3.0 -0.5 2.7 2.3
Leg fat mass (left) 0.5 1.9 5.0 -2.2 -1.1 0.7 -2.1 0.6 0.6
Arm predicted mass (left) 0.8 3.9 11.5 -3.4 -1.5 0.1 -2.8 -0.2 -1.2