Best TWAS P=1.16e-13 · Best GWAS P=3.33e-10 conditioned to 0.582
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | BMS1P5 | 0.37 | 0.13 | lasso | 7 | 0.13 | 2.7e-04 | -6.3 | 6.4 | 2.1e-10 | -0.95 | 0.00 | 0.96 | FALSE |
| 2 | GTEx | Brain Cerebellum | BMS1P5 | 0.23 | 0.15 | lasso | 1 | 0.09 | 1.0e-03 | -6.3 | 6.3 | 3.3e-10 | -1.00 | 0.00 | 0.98 | FALSE |
| 3 | GTEx | Brain Cerebellum | GLUD1P2 | 0.20 | 0.09 | lasso | 3 | 0.14 | 8.2e-05 | -6.3 | 6.4 | 1.6e-10 | -0.99 | 0.00 | 0.96 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | BMS1P5 | 0.35 | 0.15 | enet | 18 | 0.16 | 3.8e-05 | -5.7 | 5.4 | 5.8e-08 | -0.66 | 0.00 | 0.94 | FALSE |
| 5 | GTEx | Brain Nucleus accumbens basal ganglia | BMS1P5 | 0.28 | 0.11 | lasso | 4 | 0.11 | 7.5e-04 | -6.3 | 6.8 | 8.0e-12 | -0.96 | 0.00 | 0.93 | FALSE |
| 6 | GTEx | Brain Nucleus accumbens basal ganglia | GLUD1P2 | 0.37 | 0.09 | lasso | 3 | 0.03 | 4.5e-02 | -6.3 | 6.5 | 1.0e-10 | -0.97 | 0.00 | 0.86 | FALSE |
| 7 | GTEx | Brain Putamen basal ganglia | BMS1P5 | 0.27 | 0.20 | lasso | 6 | 0.06 | 1.9e-02 | -6.3 | 6.4 | 1.7e-10 | -0.98 | 0.00 | 0.97 | FALSE |
| 8 | GTEx | Cells Transformed fibroblasts | BMS1P5 | 0.10 | 0.02 | lasso | 4 | 0.02 | 5.7e-03 | -6.3 | 6.1 | 9.9e-10 | -0.88 | 0.01 | 0.84 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | GLUD1P2 | 0.08 | 0.08 | lasso | 2 | 0.07 | 4.3e-06 | -6.3 | 6.4 | 1.7e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 10 | GTEx | Heart Left Ventricle | GDF10 | 0.15 | 0.00 | enet | 10 | 0.00 | 2.7e-01 | -5.7 | -7.4 | 1.2e-13 | 0.80 | 0.01 | 0.99 | TRUE |
| 11 | GTEx | Liver | BMS1P5 | 0.22 | 0.02 | lasso | 4 | 0.04 | 3.6e-02 | -6.3 | 6.3 | 3.7e-10 | -0.92 | 0.00 | 0.97 | FALSE |
| 12 | GTEx | Muscle Skeletal | GLUD1P2 | 0.19 | 0.05 | lasso | 6 | 0.04 | 4.2e-05 | -6.3 | 5.6 | 2.1e-08 | -0.93 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Skin Sun Exposed Lower leg | BMS1P5 | 0.11 | 0.05 | lasso | 3 | 0.04 | 1.9e-04 | -6.3 | 5.8 | 5.4e-09 | -0.98 | 0.00 | 1.00 | FALSE |
| 14 | GTEx | Testis | BMS1P5 | 0.14 | 0.08 | lasso | 2 | 0.13 | 3.3e-06 | -6.3 | 5.6 | 2.7e-08 | -0.93 | 0.00 | 0.98 | FALSE |
| 15 | GTEx | Thyroid | BMS1P5 | 0.14 | 0.12 | lasso | 2 | 0.12 | 2.7e-09 | -6.3 | 6.4 | 1.7e-10 | -0.99 | 0.00 | 1.00 | FALSE |
| 16 | GTEx | Thyroid | GLUD1P2 | 0.16 | 0.14 | lasso | 1 | 0.14 | 1.2e-10 | -6.3 | 6.3 | 3.3e-10 | -1.00 | 0.00 | 1.00 | FALSE |