Best TWAS P=4.74e-33 · Best GWAS P=8.4e-37 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM53B | 0.05 | 0.00 | blup | 626 | 0.01 | 1.9e-02 | 12.67 | 7.3 | 3.0e-13 | 0.56 | 0.01 | 0.94 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | METTL10 | 0.20 | 0.26 | lasso | 9 | 0.26 | 4.5e-31 | -7.93 | -8.5 | 1.5e-17 | -0.35 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | METTL10 | 0.11 | 0.00 | enet | 15 | 0.03 | 7.3e-04 | -6.98 | -10.5 | 6.2e-26 | -0.55 | 0.50 | 0.47 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | METTL10 | 0.11 | 0.02 | lasso | 6 | 0.03 | 1.6e-02 | -9.70 | -10.5 | 1.2e-25 | -0.68 | 0.03 | 0.84 | TRUE |
| 5 | GTEx | Artery Aorta | METTL10 | 0.11 | 0.04 | enet | 18 | 0.12 | 3.9e-07 | 1.42 | -5.5 | 3.6e-08 | -0.32 | 0.58 | 0.09 | FALSE |
| 6 | GTEx | Artery Tibial | LHPP | 0.21 | 0.03 | enet | 64 | 0.11 | 1.1e-08 | -3.01 | -5.7 | 1.6e-08 | -0.04 | 0.45 | 0.03 | TRUE |
| 7 | GTEx | Brain Caudate basal ganglia | METTL10 | 0.33 | 0.16 | lasso | 3 | 0.18 | 7.6e-06 | 11.44 | -11.9 | 8.6e-33 | -0.68 | 0.26 | 0.54 | FALSE |
| 8 | GTEx | Brain Cerebellum | LHPP | 0.41 | 0.03 | enet | 34 | 0.11 | 4.1e-04 | 5.92 | 5.9 | 3.2e-09 | 0.35 | 0.09 | 0.59 | FALSE |
| 9 | GTEx | Brain Frontal Cortex BA9 | METTL10 | 0.24 | 0.00 | lasso | 3 | 0.02 | 9.3e-02 | -7.57 | -12.0 | 4.7e-33 | -0.72 | 0.08 | 0.24 | TRUE |
| 10 | GTEx | Brain Hippocampus | LHPP | 0.35 | 0.01 | lasso | 7 | 0.08 | 5.2e-03 | -0.35 | 7.6 | 2.3e-14 | 0.51 | 0.03 | 0.72 | FALSE |
| 11 | GTEx | Breast Mammary Tissue | METTL10 | 0.13 | 0.08 | enet | 19 | 0.13 | 4.8e-07 | -7.66 | -9.9 | 3.9e-23 | -0.48 | 0.82 | 0.16 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Female) | METTL10 | 0.27 | 0.00 | lasso | 5 | 0.04 | 1.8e-02 | -7.66 | -8.5 | 1.6e-17 | -0.60 | 0.09 | 0.58 | TRUE |
| 13 | GTEx | Cells Transformed fibroblasts | OAT | 0.16 | 0.00 | enet | 23 | 0.02 | 7.4e-03 | 2.88 | -5.7 | 1.6e-08 | -0.34 | 0.08 | 0.04 | FALSE |
| 14 | GTEx | Cells Transformed fibroblasts | FAM53B | 0.22 | 0.08 | lasso | 8 | 0.07 | 3.7e-06 | -7.69 | 7.4 | 1.1e-13 | 0.48 | 0.90 | 0.02 | FALSE |
| 15 | GTEx | Cells Transformed fibroblasts | METTL10 | 0.17 | 0.14 | lasso | 8 | 0.17 | 6.8e-13 | -9.20 | -8.8 | 1.1e-18 | -0.48 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Colon Transverse | METTL10 | 0.18 | 0.01 | enet | 17 | 0.07 | 2.2e-04 | 9.39 | -8.6 | 9.2e-18 | -0.49 | 0.17 | 0.10 | FALSE |
| 17 | GTEx | Esophagus Mucosa | METTL10 | 0.06 | 0.03 | enet | 11 | 0.01 | 5.1e-02 | 3.81 | -6.3 | 3.9e-10 | -0.41 | 0.28 | 0.10 | FALSE |
| 18 | GTEx | Heart Atrial Appendage | METTL10 | 0.14 | 0.00 | lasso | 6 | 0.00 | 2.7e-01 | -3.67 | -6.8 | 1.0e-11 | -0.46 | 0.08 | 0.24 | FALSE |
| 19 | GTEx | Lung | METTL10 | 0.11 | 0.06 | enet | 6 | 0.05 | 1.7e-04 | -7.93 | -8.9 | 8.0e-19 | -0.40 | 0.88 | 0.04 | FALSE |
| 20 | GTEx | Nerve Tibial | LHPP | 0.18 | 0.05 | lasso | 5 | 0.09 | 4.1e-07 | -1.73 | 6.4 | 2.0e-10 | 0.49 | 0.58 | 0.36 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | METTL10 | 0.05 | 0.04 | enet | 8 | 0.04 | 2.1e-04 | -7.57 | -7.4 | 1.7e-13 | -0.40 | 0.56 | 0.09 | TRUE |
| 22 | GTEx | Testis | METTL10 | 0.26 | 0.14 | lasso | 9 | 0.08 | 2.3e-04 | -7.93 | -8.2 | 3.1e-16 | -0.36 | 0.90 | 0.01 | FALSE |
| 23 | GTEx | Thyroid | METTL10 | 0.19 | 0.09 | enet | 33 | 0.10 | 3.0e-08 | -7.93 | -6.7 | 2.1e-11 | -0.34 | 0.99 | 0.00 | FALSE |
| 24 | METSIM | Adipose | METTL10 | 0.12 | 0.15 | enet | 27 | 0.15 | 1.1e-21 | -7.93 | -8.9 | 6.0e-19 | -0.45 | 1.00 | 0.00 | FALSE |
| 25 | NTR | Blood | LHPP | 0.04 | 0.01 | bslmm | 604 | 0.01 | 5.7e-04 | -2.96 | -5.7 | 1.1e-08 | 0.04 | 0.49 | 0.01 | FALSE |
| 26 | ROSMAP | Brain Pre-frontal Cortex | ZRANB1 | 0.09 | 0.07 | lasso | 4 | 0.06 | 1.3e-08 | 5.18 | -6.3 | 2.7e-10 | 0.07 | 1.00 | 0.00 | TRUE |
| 27 | ROSMAP | Brain Pre-frontal Cortex | LHPP | 0.22 | 0.07 | bslmm | 582 | 0.16 | 1.8e-19 | 8.30 | 5.9 | 4.2e-09 | 0.40 | 1.00 | 0.00 | FALSE |
| 28 | ROSMAP | Brain Pre-frontal Cortex | FAM53B | 0.07 | 0.01 | blup | 592 | 0.03 | 2.0e-04 | -9.20 | 5.7 | 1.2e-08 | 0.57 | 0.07 | 0.89 | FALSE |
| 29 | ROSMAP | Brain Pre-frontal Cortex | METTL10 | 0.14 | 0.16 | lasso | 7 | 0.18 | 5.5e-22 | -9.20 | -9.1 | 8.0e-20 | -0.46 | 1.00 | 0.00 | FALSE |
| 30 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | METTL10 | 0.09 | 0.08 | blup | 43 | 0.11 | 1.2e-09 | -7.93 | -7.7 | 1.6e-14 | -0.27 | 1.00 | 0.00 | FALSE |
| 31 | The Cancer Genome Atlas | Breast Invasive Carcinoma | METTL10 | 0.06 | 0.13 | lasso | 7 | 0.13 | 1.1e-25 | -7.69 | -8.1 | 6.6e-16 | -0.30 | 1.00 | 0.00 | FALSE |
| 32 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | METTL10 | 0.08 | 0.05 | blup | 43 | 0.07 | 1.9e-04 | -9.20 | -8.5 | 2.1e-17 | -0.45 | 0.70 | 0.05 | FALSE |
| 33 | The Cancer Genome Atlas | Colon Adenocarcinoma | METTL10 | 0.09 | 0.14 | lasso | 9 | 0.12 | 3.1e-07 | -6.75 | -7.4 | 1.4e-13 | -0.27 | 0.90 | 0.09 | FALSE |
| 34 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | METTL10 | 0.10 | 0.14 | blup | 43 | 0.14 | 7.4e-16 | -7.93 | -6.2 | 7.0e-10 | -0.13 | 1.00 | 0.00 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LHPP | 0.11 | 0.04 | enet | 20 | 0.04 | 9.9e-06 | 3.54 | -5.7 | 1.6e-08 | -0.09 | 0.20 | 0.02 | TRUE |
| 36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | METTL10 | 0.10 | 0.16 | lasso | 7 | 0.17 | 1.0e-18 | -7.95 | -8.8 | 8.7e-19 | -0.38 | 1.00 | 0.00 | FALSE |
| 37 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | METTL10 | 0.11 | 0.12 | lasso | 5 | 0.13 | 8.4e-08 | -7.93 | -8.5 | 2.4e-17 | -0.37 | 0.99 | 0.01 | FALSE |
| 38 | The Cancer Genome Atlas | Brain Lower Grade Glioma | METTL10 | 0.13 | 0.16 | blup | 43 | 0.18 | 1.8e-20 | -7.93 | -9.6 | 5.4e-22 | -0.48 | 1.00 | 0.00 | FALSE |
| 39 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | METTL10 | 0.11 | 0.08 | blup | 43 | 0.12 | 4.8e-06 | -7.57 | -9.9 | 3.2e-23 | -0.46 | 0.83 | 0.15 | FALSE |
| 40 | The Cancer Genome Atlas | Lung Adenocarcinoma | METTL10 | 0.11 | 0.19 | lasso | 6 | 0.19 | 7.3e-22 | -7.92 | -7.9 | 2.8e-15 | -0.26 | 1.00 | 0.00 | FALSE |
| 41 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | METTL10 | 0.05 | 0.06 | blup | 43 | 0.07 | 4.6e-08 | -7.53 | -9.6 | 9.1e-22 | -0.44 | 0.70 | 0.30 | FALSE |
| 42 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | METTL10 | 0.05 | 0.06 | lasso | 4 | 0.06 | 9.2e-05 | -6.98 | -7.4 | 1.2e-13 | -0.40 | 0.36 | 0.19 | FALSE |
| 43 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | METTL10 | 0.18 | 0.13 | enet | 12 | 0.11 | 2.4e-05 | -7.69 | -6.2 | 5.2e-10 | -0.17 | 0.32 | 0.55 | FALSE |
| 44 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | METTL10 | 0.09 | 0.10 | lasso | 2 | 0.06 | 1.5e-03 | -6.75 | -6.8 | 7.9e-12 | -0.28 | 0.20 | 0.19 | TRUE |
| 45 | The Cancer Genome Atlas | Prostate Adenocarcinoma | METTL10 | 0.10 | 0.17 | blup | 43 | 0.18 | 1.9e-18 | -7.69 | -10.2 | 1.6e-24 | -0.51 | 1.00 | 0.00 | TRUE |
| 46 | The Cancer Genome Atlas | Rectum Adenocarcinoma | METTL10 | 0.25 | 0.11 | lasso | 4 | 0.23 | 3.8e-06 | -7.69 | -8.7 | 2.5e-18 | -0.37 | 0.10 | 0.46 | TRUE |
| 47 | The Cancer Genome Atlas | Soft Tissue Sarcoma | METTL10 | 0.05 | 0.05 | blup | 43 | 0.05 | 4.4e-04 | -7.69 | -8.3 | 1.3e-16 | -0.36 | 0.25 | 0.13 | FALSE |
| 48 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | METTL10 | 0.39 | 0.21 | lasso | 5 | 0.21 | 2.9e-06 | -6.98 | -7.5 | 5.5e-14 | -0.46 | 0.55 | 0.16 | TRUE |
| 49 | The Cancer Genome Atlas | Stomach Adenocarcinoma | METTL10 | 0.07 | 0.07 | lasso | 4 | 0.07 | 6.2e-06 | -9.20 | -8.9 | 5.9e-19 | -0.46 | 0.97 | 0.02 | FALSE |
| 50 | The Cancer Genome Atlas | Thyroid Carcinoma | METTL10 | 0.25 | 0.35 | lasso | 5 | 0.36 | 5.9e-36 | -7.93 | -8.1 | 4.3e-16 | -0.33 | 1.00 | 0.00 | FALSE |
| 51 | The Cancer Genome Atlas | Thyroid Carcinoma | ZRANB1 | 0.03 | 0.00 | blup | 87 | 0.01 | 6.0e-02 | 5.04 | 5.3 | 9.1e-08 | -0.06 | 0.03 | 0.52 | FALSE |
| 52 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | METTL10 | 0.13 | 0.08 | blup | 43 | 0.12 | 2.4e-04 | -7.93 | -7.5 | 6.3e-14 | -0.28 | 0.17 | 0.18 | FALSE |