Best TWAS P=3.35e-53 · Best GWAS P=1.8e-43 conditioned to 0.322
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PLEKHA1 | 0.07 | 0.02 | enet | 18 | 0.06 | 2.0e-07 | -1.9 | 7.6 | 2.2e-14 | -0.19 | 0.12 | 0.85 | FALSE |
2 | GTEx | Adipose Subcutaneous | PLEKHA1 | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.4e-03 | 13.6 | -13.6 | 2.9e-42 | 0.50 | 0.03 | 0.96 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RP11-500G22.2 | 0.29 | 0.00 | enet | 32 | 0.01 | 7.5e-02 | -3.5 | 5.6 | 1.8e-08 | -0.08 | 0.10 | 0.06 | FALSE |
4 | GTEx | Artery Tibial | PLEKHA1 | 0.16 | 0.06 | enet | 18 | 0.08 | 1.3e-06 | 13.6 | -8.9 | 4.8e-19 | 0.42 | 0.03 | 0.97 | FALSE |
5 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-500G22.2 | 0.73 | 0.36 | lasso | 20 | 0.27 | 5.8e-08 | -3.5 | 5.5 | 3.4e-08 | -0.06 | 0.90 | 0.01 | FALSE |
6 | GTEx | Brain Putamen basal ganglia | RP11-500G22.2 | 0.40 | 0.16 | enet | 27 | 0.24 | 2.4e-06 | -1.6 | 6.3 | 2.2e-10 | -0.19 | 0.11 | 0.09 | TRUE |
7 | GTEx | Breast Mammary Tissue | PLEKHA1 | 0.30 | 0.05 | enet | 38 | 0.01 | 8.6e-02 | 13.6 | -7.7 | 1.1e-14 | 0.27 | 0.03 | 0.77 | FALSE |
8 | GTEx | Colon Sigmoid | RP11-500G22.2 | 0.54 | 0.00 | lasso | 20 | 0.08 | 1.0e-03 | 3.1 | 6.2 | 4.2e-10 | -0.11 | 0.18 | 0.05 | FALSE |
9 | GTEx | Esophagus Gastroesophageal Junction | RP11-500G22.2 | 0.22 | 0.05 | lasso | 4 | 0.12 | 5.1e-05 | -4.0 | 5.4 | 7.8e-08 | -0.05 | 0.46 | 0.03 | FALSE |
10 | GTEx | Esophagus Mucosa | RP11-500G22.2 | 0.23 | 0.03 | lasso | 10 | 0.02 | 1.4e-02 | -3.5 | 5.7 | 1.1e-08 | 0.01 | 0.42 | 0.05 | FALSE |
11 | GTEx | Muscle Skeletal | PLEKHA1 | 0.10 | 0.04 | lasso | 3 | 0.04 | 8.2e-05 | -13.6 | -12.5 | 7.7e-36 | 0.83 | 0.04 | 0.95 | FALSE |
12 | GTEx | Nerve Tibial | PLEKHA1 | 0.22 | 0.23 | enet | 17 | 0.19 | 1.1e-13 | 13.6 | -12.4 | 2.6e-35 | 0.41 | 0.03 | 0.97 | FALSE |
13 | GTEx | Pancreas | PLEKHA1 | 0.29 | 0.05 | lasso | 11 | 0.07 | 4.7e-04 | -8.3 | -9.2 | 2.5e-20 | 0.77 | 0.06 | 0.78 | FALSE |
14 | GTEx | Pancreas | TACC2 | 0.22 | 0.02 | lasso | 4 | 0.04 | 7.2e-03 | -5.9 | -6.6 | 3.1e-11 | 0.52 | 0.10 | 0.17 | FALSE |
15 | GTEx | Skin Sun Exposed Lower leg | PLEKHA1 | 0.16 | 0.02 | lasso | 5 | 0.01 | 4.0e-02 | -13.8 | -14.2 | 8.6e-46 | 0.96 | 0.01 | 0.98 | FALSE |
16 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 13.6 | -15.4 | 3.3e-53 | 0.85 | 0.01 | 0.99 | TRUE |
17 | ROSMAP | Brain Pre-frontal Cortex | PLEKHA1 | 0.06 | 0.05 | lasso | 4 | 0.05 | 1.3e-06 | -13.6 | -13.6 | 2.8e-42 | 0.65 | 0.07 | 0.93 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLEKHA1 | 0.04 | 0.05 | lasso | 2 | 0.04 | 4.3e-05 | 13.6 | -13.5 | 9.8e-42 | 0.49 | 0.02 | 0.98 | FALSE |
19 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ARMS2 | 0.23 | 0.20 | lasso | 2 | 0.21 | 7.0e-09 | -7.2 | -8.0 | 9.0e-16 | 0.12 | 0.93 | 0.01 | FALSE |
20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PLEKHA1 | 0.08 | 0.06 | blup | 103 | 0.02 | 4.0e-02 | 13.6 | -12.3 | 8.7e-35 | 0.56 | 0.02 | 0.78 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARMS2 | 0.06 | 0.04 | blup | 71 | 0.05 | 4.9e-06 | -13.6 | -10.8 | 2.3e-27 | 0.28 | 0.02 | 0.97 | FALSE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHA1 | 0.08 | 0.10 | lasso | 1 | 0.09 | 3.5e-09 | 13.6 | -13.6 | 7.4e-42 | 0.50 | 0.04 | 0.96 | FALSE |