Best TWAS P=4.64e-12 · Best GWAS P=1.47e-10 conditioned to 0.0191
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | PPP2R2D | 0.21 | 0.21 | lasso | 4 | 0.20 | 2.1e-11 | -5.6 | 5.3 | 1.4e-07 | 0.37 | 0.15 | 0.85 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | PPP2R2D | 0.22 | 0.09 | lasso | 5 | 0.13 | 6.1e-04 | -5.5 | 5.6 | 1.8e-08 | 0.42 | 0.03 | 0.58 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | PPP2R2D | 0.18 | 0.15 | enet | 6 | 0.17 | 6.4e-21 | -5.5 | 6.9 | 4.6e-12 | 0.65 | 0.03 | 0.97 | TRUE |
| 4 | The Cancer Genome Atlas | Thyroid Carcinoma | C10orf91 | 0.17 | 0.07 | enet | 14 | 0.12 | 1.2e-11 | 3.9 | -5.1 | 2.7e-07 | -0.02 | 0.38 | 0.37 | TRUE |