TWAS hub - PPP2R2D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1180	0.0360	3.3e-04	0.005	0.054	0.013	0.051	0.007	7.3e-02	3.4e-07	9.9e-03	7.4e-07	4.0e-02
2	GTEx	Adipose Subcutaneous	0.1720	0.0450	5.7e-05	0.071	NA	0.097	NA	0.097	2.1e-06	NA	2.6e-08	NA	2.6e-08
3	GTEx	Artery Aorta	0.2090	0.0640	1.3e-03	0.207	NA	0.198	NA	0.203	1.2e-11	NA	3.7e-11	NA	2.1e-11
4	GTEx	Artery Tibial	0.3210	0.0519	1.0e-10	0.223	NA	0.266	NA	0.250	2.3e-17	NA	6.0e-21	NA	1.3e-19
5	GTEx	Brain Cerebellar Hemisphere	0.4160	0.1350	3.1e-03	0.182	NA	0.112	NA	0.160	2.0e-05	NA	8.2e-04	NA	6.7e-05
6	GTEx	Breast Mammary Tissue	0.1900	0.0690	4.8e-03	0.053	NA	0.069	NA	0.092	1.1e-03	NA	2.1e-04	NA	1.9e-05
7	GTEx	Breast Mammary Tissue (Male)	0.2247	0.1573	1.2e-01	0.088	NA	0.124	NA	0.131	4.6e-03	NA	8.4e-04	NA	6.1e-04
8	GTEx	Breast Mammary Tissue (Female)	0.0800	0.0816	2.2e-01	0.015	NA	-0.003	NA	0.019	1.1e-01	NA	4.0e-01	NA	8.9e-02
9	GTEx	Colon Transverse	0.3360	0.0810	7.7e-05	0.193	NA	0.233	NA	0.231	1.5e-09	NA	2.0e-11	NA	2.5e-11
10	GTEx	Esophagus Mucosa	0.3150	0.0540	5.2e-10	0.230	NA	0.233	NA	0.255	2.1e-15	NA	1.3e-15	NA	3.7e-17
11	GTEx	Lung	0.1808	0.0462	2.6e-05	0.059	NA	0.103	NA	0.096	2.7e-05	NA	2.6e-08	NA	8.6e-08
12	GTEx	Nerve Tibial	0.2404	0.0564	2.5e-05	0.116	NA	0.143	NA	0.138	1.4e-08	NA	2.6e-10	NA	5.5e-10
13	GTEx	Skin Not Sun Exposed Suprapubic	0.1990	0.0640	1.2e-03	0.081	NA	0.093	NA	0.106	3.2e-05	NA	8.3e-06	NA	2.1e-06
14	GTEx	Skin Sun Exposed Lower leg	0.1930	0.0450	4.8e-07	0.141	NA	0.171	NA	0.170	9.2e-12	NA	4.6e-14	NA	5.5e-14
15	GTEx	Small Intestine Terminal Ileum	0.4370	0.1130	6.6e-04	0.002	NA	0.022	NA	0.018	2.9e-01	NA	1.1e-01	NA	1.3e-01
16	ROSMAP	Brain Pre-frontal Cortex	0.1830	0.0408	1.2e-06	0.149	0.057	0.167	0.160	0.166	1.2e-18	7.0e-08	6.4e-21	4.2e-20	9.5e-21
17	TCGA	Prostate Adenocarcinoma	0.0541	0.0281	2.0e-03	0.022	0.026	0.022	NA	0.016	2.1e-03	8.7e-04	2.1e-03	NA	8.0e-03
18	TCGA	Thyroid Carcinoma	0.0870	0.0340	2.3e-06	0.048	0.055	0.057	NA	0.065	1.8e-05	4.7e-06	3.0e-06	NA	6.7e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18
Number of treatments/medications taken	5.8	10.4	27.7	-2.0	-3.1	-4.5	-3.6	-0.3	-1.4	-4.6	0.3	-3.1	-1.0	-3.4	-2.2	-3.0	-3.5	-4.4	-5.3	-3.2	-3.4
Qualifications: None of the above	5.8	12.4	37.8	-4.2	-1.9	-4.4	-3.8	-1.4	0.2	-4.5	2.2	-3.4	0.8	-2.2	-3.5	-2.6	-3.6	-5.0	-6.2	-4.0	-3.4
Bipolar Disorder (2011)	5.7	5.5	10.6	1.0	2.5	2.7	2.8	-1.9	2.6	3.0	2.2	2.1	2.5	2.7	2.5	3.3	2.1	3.1	0.0	1.9	0.0
Unable to work because of sickness or disability	4.6	6.0	20.5	-4.5	-2.5	-2.7	-2.3	2.5	-2.0	-2.2	-1.5	-3.2	-1.9	-2.4	-2.2	-2.3	-2.9	-1.9	-3.0	-0.9	0.3
Qualifications: O levels/GCSEs or equivalent	4.5	7.1	16.1	3.3	2.0	3.5	3.6	1.3	0.9	3.1	-0.6	2.9	0.3	1.9	3.0	2.5	3.1	3.5	4.0	2.4	2.1
High blood pressure (siblings)	4.2	6.1	13.7	-3.7	-2.1	-2.7	-2.7	1.8	-1.6	-2.5	-0.9	-2.4	-1.3	-2.1	-2.3	-2.4	-2.1	-2.3	-3.7	-3.3	-2.8
Ever highly irritable/argumentative for 2 days	4.1	4.9	7.9	-1.3	-2.5	-2.6	-2.6	1.9	-2.2	-2.5	-1.8	-1.9	-2.0	-2.4	-1.8	-2.6	-2.2	-0.6	-2.3	-2.7	-2.8
Bipolar Disorder (2018)	4.0	6.3	12.2	0.3	2.9	3.2	3.4	-0.4	2.4	3.5	1.3	2.7	1.8	2.5	3.3	3.1	2.1	2.7	2.7	1.2	2.2
Systolic Blood Pressure	4.0	20.3	34.1	-1.5	-4.9	-5.8	-4.3	2.6	-4.8	-5.8	-3.3	-4.3	-3.9	-5.2	-3.5	-5.3	-5.1	-2.8	-4.3	-5.4	-5.4
Illnesses of siblings	3.9	5.4	8.4	2.6	2.3	2.7	2.8	-2.0	2.0	2.7	1.4	2.2	1.7	2.2	2.0	2.7	2.1	1.5	2.9	2.6	2.6
Qualifications: College or University degree	3.9	12.2	35.8	4.4	2.1	4.8	3.8	1.0	0.2	4.8	-2.0	3.7	-0.5	2.3	3.0	2.9	3.5	3.6	6.0	4.2	3.9
Serious illness, injury or assault of a close relative in last 2 years	3.6	4.2	10.5	-0.5	-2.4	-1.7	-2.1	2.9	-2.9	-1.0	-3.2	-1.8	-3.0	-2.2	-1.9	-2.6	-2.1	0.8	-0.8	-0.0	0.1
Fed-up feelings	3.2	5.8	9.7	-1.2	-2.8	-3.1	-2.9	2.0	-2.1	-2.8	-1.5	-2.6	-2.0	-3.0	-2.3	-3.1	-3.0	-1.7	-2.7	-1.3	-1.8
Qualifications: A levels/AS levels or equivalent	3.1	6.9	15.5	3.6	2.0	3.6	3.4	1.2	0.3	3.2	-0.9	3.3	0.4	2.1	3.2	2.5	3.1	2.3	3.9	2.1	1.7
Vascular/heart problems diagnosed by doctor	3.1	8.3	15.6	2.5	3.3	3.6	3.7	-0.6	1.8	3.6	1.2	3.4	1.9	3.5	2.5	3.1	3.7	3.1	3.9	1.1	1.9
Systolic blood pressure, automated reading	2.9	8.5	16.1	-1.7	-2.9	-3.9	-2.8	0.6	-2.5	-3.8	-1.6	-3.1	-2.1	-3.2	-2.5	-3.4	-4.0	-2.2	-3.0	-3.6	-3.4
Seen doctor (GP) for nerves, anxiety, tension or depression	2.9	4.4	8.3	-1.9	-2.7	-2.1	-2.5	2.9	-1.8	-2.0	-1.9	-2.7	-2.2	-2.6	-0.8	-2.3	-2.4	-1.5	-2.3	0.9	0.4
Medication: Aspirin	2.8	3.7	11.6	-0.3	-2.2	-2.7	-2.2	0.5	-1.4	-2.1	-0.9	-2.1	-1.5	-2.2	-1.6	-2.2	-1.8	-3.4	-2.6	-0.4	-0.8
Forced expiratory volume in 1-second (FEV1)	2.7	9.3	21.2	3.0	2.9	3.8	3.7	-1.0	1.2	4.1	-0.0	3.6	1.2	2.6	2.3	2.9	4.1	3.7	4.6	2.7	2.9
Overall health rating	2.5	5.5	16.6	-1.4	-1.9	-3.4	-2.3	-1.0	-0.4	-3.2	1.0	-1.8	-0.1	-2.2	-1.6	-2.0	-3.0	-2.2	-4.1	-3.1	-2.9
Average weekly champagne plus white wine intake	2.5	3.5	5.8	1.1	2.0	2.4	2.4	-2.3	1.8	1.9	1.6	1.9	1.9	2.0	1.4	2.4	1.6	0.5	1.7	1.4	2.1
Tinnitus: Yes, but not now, but have in the past	2.3	2.4	4.0	-1.1	-1.8	-2.0	-1.7	0.8	-1.7	-1.7	-1.3	-1.9	-1.6	-1.4	-1.8	-2.0	-1.6	-0.4	-1.5	-1.2	-1.4
Forced vital capacity (FVC)	2.3	8.9	17.9	3.4	2.6	3.8	3.5	-0.8	1.3	4.0	0.0	3.0	1.2	2.5	2.0	2.9	3.8	3.6	4.2	3.2	3.3
Prospective memory result	2.3	2.8	7.8	-2.8	-1.5	-2.0	-2.1	0.8	-1.2	-2.0	-0.7	-1.2	-1.0	-1.2	-1.2	-1.8	-1.0	-1.0	-2.0	-2.6	-2.1
Medication for cholesterol	2.3	3.4	6.6	0.1	2.1	2.0	1.9	-1.1	1.7	2.2	1.3	2.1	1.5	1.9	2.3	1.8	2.2	1.8	2.6	1.2	1.7
Medication: Aspirin	2.2	3.0	7.4	-0.4	-2.0	-2.5	-2.0	0.6	-1.3	-1.8	-0.7	-2.0	-1.2	-1.9	-1.5	-2.0	-1.7	-2.7	-2.5	-0.7	-0.8
Intelligence (Savage-Jansen 2018)	2.1	6.3	21.2	4.0	0.7	2.4	2.3	1.3	-0.9	3.1	-2.6	1.9	-1.6	0.8	1.3	1.1	1.7	4.2	4.6	3.4	2.0
Medication: Simvastatin	2.1	3.0	7.0	-0.9	-2.0	-2.7	-2.4	0.7	-1.4	-2.5	-0.2	-1.5	-1.0	-1.7	-1.4	-2.0	-1.5	-1.9	-2.6	-0.7	-1.9
Birth weight of first child	2.1	3.8	7.3	0.1	2.5	2.2	2.0	-2.3	2.4	2.1	2.5	1.8	2.7	2.6	1.9	2.3	1.6	1.4	0.8	0.3	0.9
Medication: Amlodipine	2.1	3.0	5.3	-1.3	-2.1	-2.3	-2.2	0.1	-1.5	-2.3	-0.9	-1.9	-1.4	-2.2	-2.0	-2.2	-1.9	-0.6	-2.0	-0.4	-1.3
Medication: Blood pressure	2.1	3.8	7.8	-2.5	-1.6	-2.5	-2.1	-1.0	-0.4	-2.8	0.4	-1.4	-0.3	-2.1	-1.0	-1.6	-2.1	-2.8	-2.8	-2.0	-2.2
Maternal smoking around birth	2.0	3.0	9.4	-0.4	-1.0	-2.7	-1.2	-0.9	0.3	-2.6	1.5	-0.9	0.4	-1.0	-0.8	-1.1	-2.1	-0.6	-3.1	-2.7	-2.8
High blood pressure	2.0	5.7	11.4	-1.9	-2.8	-3.0	-3.0	0.1	-1.4	-3.0	-0.9	-2.9	-1.5	-3.0	-2.1	-2.5	-3.3	-2.3	-3.4	-1.1	-1.8
Happiness	2.0	2.5	10.7	-0.3	-1.5	-0.2	-0.3	3.3	-2.1	0.3	-3.0	-1.2	-2.4	-1.0	-1.0	-1.3	-1.6	-0.9	0.5	1.5	1.2
Peak expiratory flow (PEF)	1.9	4.5	9.4	2.1	2.0	2.3	2.4	-1.4	1.1	2.8	0.6	2.6	1.2	1.5	1.6	2.2	3.1	2.5	2.6	2.1	2.2
Illnesses of father: Heart disease	1.9	2.7	6.4	-2.5	-1.9	-2.2	-1.8	1.3	-1.5	-2.1	-1.0	-1.7	-1.5	-1.7	-0.9	-1.8	-1.4	-1.0	-2.0	-0.9	-1.3
Medication: Blood pressure	1.9	3.6	6.4	-0.6	-2.3	-1.9	-2.1	1.7	-1.8	-1.7	-1.8	-2.2	-1.9	-2.1	-2.3	-2.1	-2.5	-1.4	-2.0	-0.4	-1.5
Number of live births	1.8	2.5	7.2	-0.5	1.9	0.6	1.5	-2.4	2.4	0.3	2.7	1.6	2.3	1.7	0.9	1.5	1.1	-1.7	-0.3	-1.1	-0.8
Depression (self-reported)	1.8	2.2	6.9	-2.6	-1.7	-1.5	-0.7	1.9	-1.3	-1.4	-1.4	-1.7	-1.5	-1.6	-0.6	-1.5	-1.7	-0.8	-1.4	-1.0	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.8	5.6	13.8	2.7	2.1	2.7	2.8	-0.7	0.5	3.1	-0.5	2.8	0.5	1.7	1.9	2.0	3.0	3.4	3.7	2.4	2.1
Qualifications: nursing, teaching	1.8	2.8	8.1	2.8	0.2	1.4	1.2	1.9	-1.1	1.7	-1.9	1.2	-1.2	0.6	1.0	0.5	1.6	2.8	2.5	1.8	1.4
Commuting to job workplace: Walk	1.8	2.0	4.7	1.6	1.3	1.4	1.2	-1.4	1.5	1.1	1.4	1.9	1.3	1.1	1.6	1.8	2.2	1.3	0.9	0.8	0.3
Average weekly spirits intake	1.7	2.1	6.3	-0.0	-1.4	-1.6	-1.7	1.0	-1.4	-1.4	-1.1	-1.3	-1.3	-1.1	-2.5	-1.8	-1.0	-1.1	-1.4	-1.7	-1.9
Heart attack	1.7	2.1	6.3	-1.0	-1.3	-2.3	-1.7	-0.0	-0.7	-2.5	0.1	-1.2	-0.4	-1.3	-1.4	-1.6	-0.9	-2.1	-2.3	-0.6	-1.4
Shortness of breath walking on level ground	1.7	2.0	4.0	-0.4	-1.7	-2.0	-1.5	0.4	-1.3	-1.5	-1.0	-1.4	-1.2	-1.8	-1.1	-1.7	-1.7	-1.6	-1.4	-1.2	-1.6
Hypertension (Self-reported)	1.7	4.8	10.5	-1.9	-2.6	-2.8	-2.7	0.2	-1.3	-2.6	-0.9	-2.6	-1.4	-2.8	-1.6	-2.2	-2.9	-2.3	-3.2	-1.1	-1.5
Wears glasses or contact lenses	1.7	2.0	5.7	-0.3	-1.4	-1.5	-2.1	0.7	-1.1	-1.1	-0.8	-1.0	-1.0	-1.3	-1.1	-1.9	-1.6	-2.1	-0.9	-1.5	-2.4
High cholesterol (Self-reported)	1.7	2.9	6.4	0.3	-2.3	-2.3	-1.9	0.9	-2.1	-2.5	-1.5	-1.8	-1.8	-1.9	-1.6	-2.0	-1.3	-0.5	-1.9	-0.3	-1.4
Medication: Bendroflumethiazide	1.7	2.6	5.7	-0.8	-2.0	-1.7	-1.5	1.0	-1.6	-1.8	-1.5	-2.0	-1.7	-1.9	-1.2	-1.7	-1.4	-2.4	-1.8	-0.5	-1.2
Medication: Paracetamol	1.7	2.6	9.9	-0.8	0.0	-1.8	-0.3	-1.8	0.9	-1.6	2.1	0.5	1.3	-0.7	0.7	-0.5	-0.8	-1.7	-2.2	-3.1	-3.1
Average weekly red wine intake	1.6	2.4	6.7	2.4	1.1	1.7	1.5	-0.2	0.7	1.8	0.1	1.6	0.6	0.7	1.8	1.6	1.4	2.6	1.7	1.8	1.8
Illnesses of father: High blood pressure	1.6	2.0	4.8	0.0	-2.0	-1.5	-1.0	0.6	-1.6	-1.0	-1.8	-1.5	-2.1	-2.2	-1.5	-1.2	-1.8	0.3	-1.7	-0.1	-0.9
Schizophrenia vs Biploar Disorder	1.5	2.0	3.8	0.9	-1.7	-1.3	-1.5	1.2	-1.9	-1.5	-1.7	-1.3	-1.8	-1.4	-1.5	-1.8	-1.6	-1.2	-1.0	-0.3	-0.4
Taking other prescription medications	1.5	2.3	10.0	-1.9	-1.1	-2.1	-1.5	-0.4	0.1	-2.0	0.9	-1.2	0.1	-1.2	-0.5	-1.0	-0.9	-1.8	-3.2	-2.1	-1.6
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.9	0.1	1.4	1.0	1.7	-1.3	1.6	0.8	1.7	1.2	1.6	1.7	2.0	1.8	1.9	0.7	0.5	1.2	1.4
Medication: Lansoprazole	1.5	1.7	6.5	-1.0	-0.7	-1.4	-0.8	-0.7	-0.1	-1.6	0.5	-0.8	0.1	-0.8	-0.6	-0.7	-1.2	-1.9	-2.5	-2.6	-1.9
Forced vital capacity (FVC), Best measure	1.5	5.5	10.4	3.1	2.1	2.8	2.8	-0.8	1.0	3.0	0.0	2.5	0.9	1.8	1.8	2.2	2.9	3.1	3.2	2.8	2.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	6.6	-1.4	-0.0	-1.2	-0.8	-1.8	1.3	-1.4	1.8	-0.9	1.3	-0.7	-1.4	-0.2	-0.2	-2.6	-2.1	-1.0	-0.8
Leg fat-free mass (right)	1.5	8.1	17.5	-0.1	3.0	3.6	3.4	-1.9	2.3	3.4	1.1	3.9	1.9	2.0	4.2	3.2	2.7	2.3	4.0	2.5	2.3
Leg predicted mass (right)	1.5	8.1	17.7	-0.0	3.0	3.6	3.4	-1.8	2.3	3.4	1.0	3.9	1.9	2.0	4.2	3.2	2.7	2.3	4.1	2.6	2.3
Pain type(s) experienced in last month: Hip pain	1.5	1.9	8.3	-2.1	-0.9	-1.8	-1.2	-0.3	0.2	-1.7	0.9	-1.5	0.3	-1.1	-0.0	-0.9	-0.8	-2.9	-2.3	-1.1	-1.2
Cardiovascular Disease	1.4	4.7	11.6	-1.6	-2.5	-3.0	-2.5	-0.1	-1.3	-2.9	-0.6	-2.3	-1.2	-2.7	-1.2	-2.1	-2.3	-3.0	-3.4	-1.3	-1.7
Angina	1.4	1.8	11.0	-3.3	0.3	-0.8	-0.5	-1.2	1.0	-0.8	1.5	-0.4	1.3	0.3	-0.6	0.0	-0.5	-2.4	-2.0	-1.3	-0.9
Qualifications: CSEs or equivalent	1.4	1.8	3.7	0.1	1.4	1.6	1.3	-1.2	1.5	1.5	1.2	1.2	1.4	1.0	1.4	1.6	1.6	0.5	1.1	1.9	1.5
Alcohol usually taken with meals	1.4	2.2	8.5	2.9	1.2	1.6	1.6	-1.9	0.9	1.0	0.6	1.9	0.9	1.3	0.6	1.5	1.7	1.4	1.9	1.4	0.8
Alcohol intake versus 10 years previously	1.4	2.1	8.6	-2.1	1.6	0.5	-0.0	-1.4	2.6	0.3	2.9	0.5	2.6	1.5	0.6	1.2	1.1	-0.5	-0.7	0.5	0.9
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	7.1	1.8	1.3	2.1	1.7	0.7	0.5	2.1	-0.2	1.1	0.4	1.8	0.8	1.4	1.6	2.7	2.0	1.0	1.5
Medication for pain relief, constipation, heartburn	1.4	2.3	9.2	0.9	0.9	2.0	1.3	1.2	-0.4	1.8	-1.2	0.8	-0.4	1.5	0.3	1.0	1.6	3.0	2.2	1.9	2.1
Supplements: Vitamin C	1.4	1.7	7.6	-0.7	-1.2	-1.6	-1.3	0.8	-0.6	-1.9	-0.4	-1.1	-0.8	-1.8	-0.8	-1.5	-1.2	-2.8	-0.9	-1.0	-0.5
Had other major operations	1.3	1.6	6.6	0.3	1.3	-0.2	0.2	-2.0	1.7	0.0	2.6	1.1	2.0	1.3	0.4	0.5	0.3	-0.1	-1.0	-2.2	-1.0
Neuroticism score	1.3	2.6	7.8	-0.0	-1.4	-2.5	-1.8	-0.2	-0.6	-2.7	0.5	-1.7	-0.3	-1.6	-1.8	-1.8	-1.5	-0.8	-2.8	-1.9	-1.3
Medication: Paracetamol	1.3	2.1	7.5	-0.4	0.4	-1.5	0.2	-1.9	1.4	-1.4	2.4	0.8	1.7	-0.3	1.1	-0.1	-0.3	-0.8	-1.5	-2.7	-2.7
Leg fat percentage (right)	1.3	4.7	19.6	-4.4	0.0	-2.1	-1.3	-2.2	1.6	-1.9	2.5	-0.6	1.5	-1.2	0.8	-0.6	-2.2	-3.0	-2.6	-3.0	-2.5
Exposure to tobacco smoke outside home	1.3	1.7	5.3	-1.0	1.4	0.7	1.4	-2.0	1.9	0.1	2.3	0.8	2.1	1.4	1.0	1.4	1.2	0.8	0.8	-0.2	-0.0
Wheeze or whistling in the chest in last year	1.3	2.2	8.2	-1.8	-1.2	-1.8	-2.0	-0.1	0.3	-1.6	0.6	-1.6	0.1	-1.9	-1.0	-1.2	-2.1	-2.9	-1.8	-0.2	-0.7
Mineral and other dietary supplements	1.3	1.8	4.1	1.2	-1.6	-0.9	-1.0	0.9	-2.0	-1.0	-2.0	-1.6	-1.9	-1.7	-1.4	-1.3	-1.4	-0.4	-0.5	0.3	0.1
Diastolic blood pressure, automated reading	1.3	4.0	8.8	-1.8	-1.6	-2.4	-1.7	-0.9	-0.9	-3.0	-0.2	-2.0	-0.7	-2.2	-1.5	-2.0	-3.0	-2.6	-2.0	-2.4	-2.4
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	12.0	-3.5	-0.9	-1.0	-1.1	1.1	-0.5	-1.3	-0.4	-1.1	-0.6	-0.8	-1.0	-1.1	-0.8	-1.6	-1.3	-1.1	-0.7
Pain experienced in last month	1.3	2.2	6.4	1.4	-1.2	-0.1	-0.9	2.5	-2.0	-0.0	-2.5	-1.1	-2.2	-0.7	-1.7	-1.1	0.4	2.0	1.0	1.3	0.9
Rheumatoid Arthritis	1.2	1.6	3.6	1.2	1.4	1.4	1.6	-0.8	0.8	1.0	0.9	1.4	0.9	1.4	1.8	1.4	1.5	1.9	1.4	-0.1	0.6
Lung FVC	1.2	6.0	21.0	4.6	2.3	2.5	1.8	-1.8	1.9	2.6	1.4	2.1	1.6	2.3	1.0	2.2	2.4	3.0	2.9	3.0	2.7
Pack years adult smoking proportion	1.2	1.8	5.9	-2.1	0.5	-0.7	0.1	-2.4	1.4	-1.7	2.4	0.1	1.8	-0.2	1.5	0.5	-0.2	-1.9	-1.3	-0.6	-0.6
Leg fat-free mass (left)	1.2	6.2	16.0	-0.6	2.6	3.1	3.0	-1.3	2.0	3.0	0.8	3.5	1.6	1.7	4.0	2.7	2.3	1.9	3.7	2.0	1.7
Sitting height	1.2	8.4	25.2	2.6	2.3	4.4	3.8	0.7	0.6	3.9	-1.3	3.8	0.3	2.1	3.6	2.9	3.4	2.3	5.0	1.7	1.7
Leg predicted mass (left)	1.2	6.5	16.1	-0.7	2.7	3.2	3.1	-1.3	2.1	3.1	0.8	3.5	1.6	1.7	4.0	2.8	2.4	2.0	3.8	2.1	1.8
Fluid intelligence score	1.2	2.5	11.2	3.3	-0.9	0.5	0.4	1.4	-1.8	0.7	-2.8	0.1	-2.1	-0.9	-0.0	-0.5	0.3	1.8	2.0	2.2	0.9
Medication: Cholesterol lowering	1.2	1.8	4.1	-1.6	-1.4	-2.0	-1.7	0.9	-1.2	-1.7	-0.6	-1.0	-1.0	-1.5	-0.3	-1.6	-1.5	-1.8	-1.5	-0.4	-1.0
Illnesses of mother	1.2	1.5	6.1	1.8	1.4	1.5	1.3	0.3	0.7	1.5	0.2	1.7	0.6	1.0	1.1	1.2	1.1	2.5	1.1	-0.2	0.5
Angina (self-reported)	1.2	1.5	9.4	-3.1	0.6	-0.3	-0.1	-1.2	1.3	-0.3	1.7	-0.1	1.5	0.7	-0.3	0.5	-0.1	-2.1	-1.7	-1.0	-0.5
Heart disease (mother)	1.2	1.5	3.6	-1.5	1.3	1.0	0.9	-0.6	1.9	1.1	1.9	0.9	1.9	1.7	0.9	1.2	0.9	-0.8	0.3	0.3	0.7
Breast cancer (self-reported)	1.2	1.4	3.8	1.9	1.5	0.4	0.8	-1.6	1.4	0.6	1.7	1.7	1.5	1.2	1.0	0.8	0.6	1.1	0.7	-1.1	-0.4
Number of self-reported non-cancer illnesses	1.2	2.0	8.2	-1.7	-0.6	-1.9	-1.1	-1.3	0.9	-2.0	1.9	-1.0	1.1	-0.6	-0.2	-0.5	-0.4	-1.8	-2.9	-1.4	-1.2
Ever smoked	1.2	2.1	6.4	-1.8	1.7	0.6	0.8	-1.6	2.3	0.9	2.5	1.8	2.4	1.0	1.1	1.2	0.9	-0.9	0.1	-1.0	-1.0
Leg fat percentage (left)	1.2	4.3	17.0	-4.1	0.8	-1.3	-0.6	-3.0	2.4	-1.2	3.1	0.0	2.3	-0.6	1.4	0.2	-1.6	-2.7	-2.2	-2.6	-1.9
Basal cell carcinoma (self-reported)	1.2	1.4	5.6	-0.7	-1.0	-0.8	-0.7	1.9	-1.8	-0.5	-2.4	-0.1	-2.0	-0.9	-0.9	-1.4	-0.5	-1.1	1.2	-0.2	-0.0
Pack years of smoking	1.2	1.7	7.0	-1.6	0.4	-0.7	-0.2	-2.6	1.2	-1.7	2.4	-0.1	1.7	-0.2	1.3	0.4	-0.0	-1.7	-1.6	-0.5	-0.6
Verbal and Numeric Reasoning (VNR)	1.1	2.7	9.2	2.6	0.5	1.5	1.4	0.6	-0.5	1.5	-1.6	1.6	-1.0	0.4	1.4	0.6	1.0	2.8	3.0	2.7	1.2
Pain all over the body in last month	1.1	1.2	4.1	-2.0	0.5	-0.7	0.0	-1.3	0.9	-0.9	1.7	-0.0	1.3	-0.1	0.5	-0.1	0.1	-1.5	-1.4	-1.7	-1.0
Pulse wave reflection index	1.1	1.3	6.8	-0.9	0.8	1.3	1.1	-0.2	1.2	1.4	0.5	0.2	0.8	1.2	0.1	1.2	1.5	1.1	0.5	1.6	2.6
Arm predicted mass (right)	1.1	5.6	12.5	-1.3	2.8	2.8	2.8	-2.1	2.6	2.6	1.8	3.1	2.4	1.9	3.5	2.8	1.8	0.9	2.8	1.3	1.3
Loneliness, isolation	1.1	1.5	3.7	-1.6	-1.3	-1.6	-1.9	0.6	-0.7	-1.6	-0.4	-0.9	-0.8	-1.4	-0.5	-1.7	-1.9	-1.2	-0.9	-0.7	-0.5
Long-standing illness, disability or infirmity	1.1	1.7	6.9	0.1	-1.3	-1.9	-1.3	-1.1	-0.1	-1.8	0.6	-1.1	-0.0	-1.3	-1.1	-0.8	-1.5	-1.3	-2.6	-1.2	-1.0
Ever had bowel cancer screening	1.1	1.3	6.7	0.7	0.8	-0.3	0.1	-1.9	1.6	-0.2	2.6	0.7	1.9	0.8	0.2	0.8	0.7	0.4	-0.6	-1.2	-0.9
Friendships satisfaction	1.1	1.3	6.6	-1.4	0.3	1.5	0.6	2.6	-0.5	1.6	-1.6	0.6	-0.9	0.2	0.3	0.4	0.2	-0.9	0.9	1.1	1.7
Illnesses of father: None of the above (group 1)	1.1	1.3	4.1	1.0	1.3	1.6	1.3	0.5	0.6	2.0	0.2	1.0	0.9	1.6	0.7	1.1	1.5	0.9	1.5	0.2	0.8
Average weekly beer plus cider intake	1.1	1.6	4.3	-0.8	1.5	0.1	1.4	-1.3	1.6	0.7	1.8	1.5	1.5	1.4	1.5	0.9	0.5	0.3	0.1	-2.1	-1.4
Heart attack/myocardial infarction (self-reported)	1.1	1.4	4.7	-1.1	-1.1	-1.9	-1.2	-0.2	-0.5	-2.2	0.2	-0.9	-0.2	-1.1	-1.0	-1.2	-0.7	-1.5	-2.1	-0.5	-1.3
Bipolar Disorder or Schizophrenia	1.0	2.5	6.0	1.8	1.7	1.8	2.4	0.2	1.2	2.3	0.1	1.7	0.7	1.4	2.3	1.7	1.0	0.9	1.9	0.8	1.4
Hand grip strength (left)	1.0	2.6	6.0	0.9	1.5	2.0	1.7	-2.4	1.2	2.3	0.8	1.3	1.2	1.6	1.0	2.0	1.7	2.2	1.2	1.5	0.6
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.9	-0.9	-0.2	-1.5	-1.4	-1.9	0.5	-1.5	1.7	-0.7	0.9	-0.3	-1.1	-0.6	-0.8	-0.4	-2.0	-1.3	-0.6
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	3.3	0.8	-0.9	-1.1	-1.1	-0.7	-0.6	-1.5	-0.1	-1.1	-0.4	-0.6	-1.5	-1.1	-0.9	-1.8	-1.4	-1.1	-1.5
Supplements: Glucosamine	1.0	1.3	3.7	-0.4	1.2	1.0	1.6	-0.8	1.1	0.9	0.6	1.5	0.8	0.9	1.6	1.3	1.9	1.4	0.9	0.3	-0.3
Arm fat-free mass (right)	1.0	5.4	11.9	-1.2	2.8	2.8	2.8	-2.0	2.5	2.6	1.8	3.0	2.3	1.8	3.5	2.8	1.6	1.1	2.7	1.1	1.2
Comparative body size at age 10	1.0	2.8	5.6	1.8	1.9	1.6	1.7	-1.9	1.9	1.4	1.8	2.3	1.8	1.4	2.4	1.8	1.1	0.8	1.7	0.9	1.4
Emphysema/chronic bronchitis	1.0	1.1	2.3	-0.8	-1.2	-1.3	-1.0	1.0	-0.9	-1.2	-0.9	-1.5	-0.9	-1.2	-0.8	-1.2	-1.2	-1.4	-0.9	0.5	0.0
Migraine (self-reported)	1.0	1.3	5.9	1.4	-0.8	0.1	-0.0	1.6	-0.8	0.3	-1.5	-1.1	-1.2	-0.7	-0.5	-0.3	-0.1	1.3	0.3	2.4	1.9
Whole body fat-free mass	1.0	5.7	13.5	-0.4	2.6	3.1	3.0	-1.5	1.9	2.8	0.7	3.4	1.6	1.6	3.7	2.7	2.0	1.8	3.6	1.7	1.5
Whole body water mass	1.0	5.6	13.6	-0.4	2.6	3.1	3.0	-1.4	1.9	2.8	0.7	3.4	1.6	1.6	3.7	2.7	2.1	1.7	3.6	1.6	1.4
Ever taken oral contraceptive pill	1.0	1.1	2.3	-0.7	-1.3	-1.0	-1.0	1.2	-1.2	-1.0	-1.4	-0.8	-1.4	-1.5	-1.0	-1.1	-1.2	-0.7	-0.4	-0.3	-0.3
Medication: Lisinopril	1.0	1.3	3.2	0.3	-1.8	-1.3	-1.5	0.2	-1.3	-1.2	-1.0	-1.4	-1.2	-1.3	-1.4	-1.1	-1.3	-0.2	-1.1	0.2	-0.7
Basal metabolic rate	1.0	5.4	15.1	-0.9	2.6	2.9	2.9	-1.6	2.1	2.7	1.0	3.3	1.7	1.5	3.9	2.7	1.9	1.4	3.3	1.4	1.3
Age started oral contraceptive pill	1.0	1.3	3.9	1.9	-0.8	-0.8	-0.7	0.9	-1.4	-0.0	-1.3	-0.9	-1.3	-0.7	-2.0	-1.2	-0.5	1.8	0.4	-0.1	-1.1
Breast Cancer	0.9	2.3	7.6	1.9	0.9	1.7	1.4	-0.3	0.9	1.5	0.1	1.0	0.3	1.0	0.7	1.2	1.1	2.4	2.1	2.3	2.8
Allergy or Eczema	0.9	2.4	4.8	0.9	1.8	1.9	1.7	-0.8	1.4	2.1	1.3	2.0	1.7	1.7	2.2	2.0	2.0	0.8	1.3	-0.3	0.1
Type 2 Diabetes (T2D) (2018)	0.9	1.6	3.3	1.2	1.3	1.3	1.5	-1.4	1.3	1.7	0.8	1.6	0.9	1.0	1.8	1.3	1.4	0.8	1.3	1.0	1.1
Neuroticism	0.9	2.2	7.9	1.0	-0.9	-2.1	-1.6	-0.6	-0.4	-2.3	0.7	-1.0	-0.1	-1.2	-1.5	-1.6	-1.2	-1.0	-2.8	-2.3	-1.4
Frequency of depressed mood in last 2 weeks	0.9	1.2	12.6	-3.6	-0.5	-0.7	-0.5	1.3	-0.0	-0.5	-0.1	-0.6	-0.3	-0.9	0.7	-0.7	-1.5	-1.1	-0.3	-0.2	0.3
Diabetes (father)	0.9	1.1	2.9	-0.1	-1.1	-1.2	-1.5	1.0	-1.1	-1.0	-0.9	-0.5	-1.2	-1.7	-0.6	-1.3	-1.4	-0.3	-0.4	-0.7	-1.1
Number of incorrect matches in round	0.9	1.5	4.9	2.2	-1.0	-1.6	-0.9	0.4	-0.8	-1.6	-0.4	-0.1	-0.6	-0.9	-1.2	-1.1	-0.6	-1.1	-1.4	-1.8	-1.8
Standing height	0.9	8.6	27.8	2.2	2.2	4.3	3.7	0.9	0.3	4.0	-1.7	3.7	0.0	2.1	3.6	2.7	3.1	2.7	5.3	2.3	2.1
Number of full brothers	0.9	1.2	3.4	-1.5	1.2	0.7	0.2	-0.7	1.4	0.1	1.3	0.7	1.3	1.2	1.1	0.6	-0.2	-1.9	0.3	-1.4	-1.2
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	4.5	-0.3	0.7	-0.3	-0.1	-2.0	1.4	-0.0	2.1	0.2	1.7	0.8	0.6	0.4	0.3	-1.5	-0.8	-1.3	-0.6
Eye problems/disorders: Cataract	0.9	1.1	5.3	-0.3	-0.0	-0.8	-0.8	-1.3	0.8	-1.1	1.6	-0.6	1.2	-0.0	-0.3	0.0	0.3	-1.1	-2.3	-1.5	-1.0
Ever had prostate specific antigen (PSA) test	0.9	1.0	4.7	0.9	0.8	-0.2	0.4	-2.2	1.2	-0.4	1.9	0.6	1.6	0.6	0.5	0.6	0.9	0.9	-0.6	-0.7	-0.9
Supplements: Calcium	0.9	0.9	6.0	-2.4	-0.7	-0.6	-0.9	1.6	-0.8	-0.2	-0.9	-0.6	-1.0	-0.3	-0.5	-1.1	-0.6	-0.8	0.6	0.6	0.8
Mean Putamen Volume	0.8	1.0	4.5	-1.7	-0.7	-0.3	-0.1	2.1	-0.9	-0.2	-1.3	-0.7	-1.3	-0.8	-0.4	-0.7	-1.4	-1.1	0.2	-0.3	0.3
BMI	0.8	4.8	14.1	-2.9	2.1	0.9	1.7	-3.8	3.1	0.8	3.4	2.3	3.1	0.8	3.1	2.1	0.7	-0.7	-0.1	-1.5	-1.0
Height	0.8	16.0	47.9	2.6	3.5	5.3	4.8	0.1	1.5	5.6	-0.9	4.6	1.0	3.3	4.7	3.7	4.1	4.2	6.9	4.3	3.8
Sensitivity / hurt feelings	0.8	1.3	5.4	-0.3	0.8	-0.8	-0.4	-1.7	1.2	-1.3	1.9	0.8	1.2	0.0	-0.4	-0.3	-0.3	-1.5	-1.2	-2.3	-1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.5	-0.7	-1.1	-1.0	-0.7	0.7	-1.4	-0.2	-1.6	-0.7	-1.6	-1.1	-0.3	-1.1	-0.7	-0.3	-0.3	-0.2	-0.6
Impedance of leg (right)	0.8	4.0	8.3	-0.7	-2.1	-2.3	-2.0	1.9	-1.5	-2.2	-0.8	-2.7	-1.3	-1.4	-2.2	-2.0	-1.9	-2.3	-2.9	-2.5	-1.8
Current tobacco smoking	0.8	1.3	6.3	-2.4	-0.5	-1.0	-0.9	1.1	-0.2	-1.0	0.1	-0.3	-0.2	-0.8	0.1	-0.9	-1.6	-2.5	-0.5	-1.3	-0.9
Hayfever, allergic rhinitis or eczema	0.8	1.6	3.9	0.1	1.5	1.4	1.6	-0.9	1.4	1.4	1.3	1.6	1.4	1.4	2.0	1.6	1.3	0.3	0.4	-1.0	-0.1
Allergy	0.8	1.8	5.8	1.7	-1.1	-0.0	-1.0	1.7	-1.9	-0.1	-2.4	-0.6	-2.0	-1.0	-1.2	-1.2	-0.9	1.2	1.3	1.3	1.0
Trunk fat-free mass	0.8	4.4	12.0	-0.1	2.2	2.8	2.8	-1.0	1.4	2.5	0.2	3.1	1.2	1.4	3.3	2.3	1.7	1.6	3.5	1.2	1.0
Falls in the last year	0.8	1.0	8.0	-2.8	-0.7	-0.9	-0.4	-0.5	0.0	-1.3	0.3	-1.0	-0.1	-0.7	-0.4	-0.5	-0.4	-1.5	-1.5	-0.5	-0.3
Trunk predicted mass	0.8	4.4	12.0	-0.2	2.2	2.8	2.8	-1.0	1.5	2.5	0.3	3.1	1.2	1.4	3.3	2.3	1.7	1.6	3.5	1.3	1.0
Exposure to tobacco smoke at home	0.8	0.9	4.4	-2.1	-0.2	-0.9	-0.5	-0.0	0.1	-1.2	0.7	-0.4	0.6	-0.0	-0.4	-0.5	-0.9	-0.4	-1.3	-1.8	-1.2
Gout (self-reported)	0.8	1.1	14.0	-3.7	-0.2	0.5	-0.3	0.2	0.2	0.5	-0.1	-0.5	-0.0	-0.0	-0.2	0.3	-0.7	1.2	-1.3	-0.8	-0.6
Alcohol intake frequency.	0.8	1.9	8.2	-2.9	0.1	-1.0	-1.1	-1.4	1.6	-1.1	2.5	-1.2	1.7	-0.1	0.1	0.2	-0.4	-1.1	-2.0	1.0	1.1
Number of full sisters	0.8	1.0	2.6	-1.2	0.7	1.3	0.7	0.5	0.7	1.5	-0.3	0.8	-0.1	0.4	1.4	1.0	1.3	-1.6	1.3	0.8	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.5	0.4	0.8	0.8	0.4	-0.8	1.0	0.9	0.9	1.5	1.0	0.7	1.0	1.0	1.2	-0.8	0.3	-1.6	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	12.7	3.6	0.6	0.8	0.1	-0.5	-0.4	1.2	-0.5	0.9	-0.1	0.3	-0.3	0.4	2.0	1.7	1.6	2.0	1.2
Arm fat mass (left)	0.8	3.2	10.6	-2.7	1.9	1.0	1.5	-2.5	2.5	1.0	2.4	1.9	2.2	0.6	3.2	1.7	0.5	-0.7	0.9	-0.5	-0.4
Myopia	0.8	1.2	5.0	-0.4	-0.5	0.7	-0.4	1.9	-1.2	0.6	-2.2	0.2	-1.6	-1.0	-1.4	-0.4	0.9	0.1	1.4	1.1	0.1
Depressed Affect (Nagel 2018)	0.7	1.5	4.4	-1.6	-0.9	-1.5	-1.5	0.4	-0.1	-1.8	0.2	-0.6	-0.2	-1.3	-0.3	-1.2	-1.6	-1.6	-2.1	-0.8	-1.0
Alzheimer’s Disease (in father)	0.7	0.7	2.6	0.4	1.0	0.2	0.4	-1.6	1.2	0.0	1.5	0.9	1.4	0.8	0.4	0.7	0.9	0.4	0.2	0.5	-0.2
Major Depression (MDD)	0.7	0.9	5.2	-2.3	0.4	1.0	0.5	1.3	0.8	1.0	0.5	-0.2	0.6	0.3	1.1	0.7	0.2	-0.6	-0.4	0.9	1.4
HbA1C	0.7	0.7	2.9	-0.1	-0.6	-1.0	-0.5	1.1	-0.7	-0.7	-0.7	-0.3	-1.2	-0.7	0.2	-1.1	-1.2	-0.2	0.1	-1.2	-1.7
Type 2 Diabetes (T2D) (2012)	0.7	0.8	5.3	-0.8	-0.4	0.2	0.5	2.3	-1.0	0.4	-1.6	0.3	-1.2	-0.1	0.1	-0.3	-0.5	-1.1	0.9	-0.6	0.1
Blood White Count	0.7	5.4	20.3	-1.1	-0.1	-2.2	-0.9	-3.5	1.1	-2.5	3.1	0.4	2.0	-1.1	0.0	-0.4	-1.6	-3.6	-2.9	-4.5	-3.4
Supplements: Zinc	0.7	0.7	2.6	-0.3	-0.1	1.0	0.4	1.4	-0.3	0.6	-1.3	0.1	-0.8	-0.1	0.8	0.2	-0.2	0.4	1.4	1.3	1.6
Medication: Metformin	0.7	1.0	5.2	0.8	0.7	0.0	0.8	-2.3	1.3	0.2	1.6	0.9	1.4	0.6	1.4	0.8	0.7	0.3	-0.5	-0.1	-0.2
Age when periods started (menarche)	0.7	1.8	7.3	-0.1	1.4	0.3	0.5	-2.2	2.0	0.5	2.7	0.6	2.5	1.6	0.6	1.0	1.5	0.1	-0.5	-0.4	0.0
Trunk fat mass	0.7	3.1	10.6	-3.1	1.8	0.9	1.3	-2.4	2.4	0.9	2.2	1.7	2.1	0.5	3.2	1.6	0.3	-0.8	0.6	-0.8	-0.3
Waist circumference	0.7	2.4	10.2	-3.2	1.4	0.0	0.6	-2.7	2.2	0.2	2.3	1.2	1.9	0.0	2.2	0.9	-0.7	-0.8	-0.1	-1.3	-0.7
Past tobacco smoking	0.7	1.3	3.8	1.5	-1.2	0.1	-0.4	1.6	-1.9	-0.5	-2.0	-1.1	-1.8	-0.5	-0.3	-0.5	-0.2	0.7	0.1	1.3	1.3
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.3	-1.2	-1.2	-0.6	-1.1	1.6	-0.7	-1.0	-1.1	-1.3	-1.1	-1.2	-1.0	-1.2	-1.8	-0.2	-0.7	-0.5	0.2
Weight	0.7	3.3	11.9	-2.2	2.1	1.7	1.9	-2.0	2.1	1.7	1.4	2.5	1.8	0.8	3.5	1.9	0.8	-0.0	1.9	0.3	0.4
Noisy workplace	0.7	0.9	3.2	-1.1	-0.1	-0.8	-1.2	-1.8	0.7	-1.1	1.5	-0.8	1.0	-0.4	-0.2	-0.2	-0.8	-0.6	-1.5	-0.7	-0.6
Arm fat mass (right)	0.7	2.9	9.1	-2.9	1.7	0.7	1.2	-2.4	2.4	0.7	2.3	1.8	2.1	0.4	3.0	1.5	0.3	-0.9	0.6	-0.7	-0.5
Tense / ‘highly strung’	0.7	1.2	4.1	-0.0	-1.1	-1.4	-1.1	-0.3	-0.4	-1.9	0.1	-1.6	-0.3	-1.4	-0.9	-1.0	-1.4	0.3	-2.0	-0.4	0.0
Blood clot in the leg (DVT)	0.7	0.9	3.7	-1.9	0.3	-0.6	0.2	-1.1	1.1	-0.7	1.9	0.0	1.4	0.3	0.1	0.2	-0.1	-1.4	-1.2	-0.6	-0.4
Body fat percentage	0.7	2.6	12.8	-3.6	0.9	-0.4	0.1	-2.2	2.1	-0.3	2.5	0.6	1.9	-0.2	2.3	0.7	-0.7	-1.9	-0.9	-1.5	-1.1
Mean time to correctly identify matches	0.7	1.3	4.9	-0.6	-0.4	-1.5	-0.9	-0.1	-0.1	-1.5	0.0	-0.5	-0.2	-1.0	-0.7	-1.1	-1.2	-2.1	-1.2	-2.2	-1.5
Whole body fat mass	0.7	2.8	10.3	-3.2	1.6	0.7	1.0	-2.3	2.4	0.7	2.3	1.6	2.1	0.3	3.1	1.4	0.0	-1.0	0.4	-0.8	-0.5
Leg fat mass (right)	0.7	2.7	16.2	-4.0	0.8	-0.6	-0.0	-2.2	1.8	-0.5	2.2	0.6	1.7	-0.5	2.0	0.4	-1.0	-2.0	-1.0	-1.8	-1.4
Leg pain on walking	0.7	0.9	2.5	-1.5	-0.8	-1.1	-1.6	1.1	-0.5	-0.8	-0.2	-0.6	-0.4	-0.4	-0.8	-1.0	-0.0	-0.6	-1.0	-1.4	-1.5
Knee pain experienced in last month	0.7	1.1	4.4	-2.1	0.6	0.0	0.2	-1.0	1.0	0.1	1.3	0.2	1.2	0.5	0.7	0.3	-1.5	-1.2	-1.1	-2.1	-0.4
Illnesses of siblings: Diabetes	0.7	0.9	3.1	0.0	-1.0	-1.4	-1.0	-0.3	-0.8	-1.8	-0.4	-0.6	-0.6	-1.4	-0.2	-1.1	-0.9	-1.2	-0.6	-0.5	-1.0
Smoking status: Previous	0.7	1.0	3.6	-0.8	1.1	-0.1	0.4	-1.9	1.8	0.4	1.8	0.9	1.6	0.7	-0.1	0.5	0.5	-0.6	-0.3	-1.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.6	4.6	-0.1	1.4	1.7	1.9	0.5	0.8	1.7	0.1	1.7	0.8	1.1	2.1	1.3	1.4	0.0	1.6	0.0	0.4
Asthma (self-reported)	0.7	1.4	11.4	-3.4	-0.7	-1.3	-0.6	0.2	0.3	-1.2	0.1	-1.1	-0.2	-1.1	-0.6	-0.6	-0.6	-1.8	-1.4	-0.7	-1.2
Osteoporosis (self-reported)	0.7	0.8	3.7	-0.9	0.5	0.8	0.6	-0.1	0.1	1.1	0.0	1.0	0.2	0.7	1.9	0.5	1.5	-0.7	1.4	1.2	0.6
Smoking status: Current	0.7	1.1	3.4	-1.8	-0.7	-1.0	-0.9	1.5	-0.6	-0.9	-0.5	-0.2	-0.6	-1.0	0.0	-1.0	-1.6	-1.6	-0.2	-1.3	-1.2
Arm fat-free mass (left)	0.7	3.5	9.7	-1.2	2.2	2.3	2.2	-1.7	1.9	2.0	1.3	2.6	1.8	1.2	3.1	2.2	1.2	0.7	2.2	0.8	0.8
Cholesterol lowering medication	0.7	1.0	4.2	0.9	-1.1	-1.3	-0.9	-0.2	-0.7	-1.6	0.1	-0.9	-0.3	-0.4	-1.6	-0.7	-0.7	-0.6	-2.1	-0.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	5.0	-2.2	0.3	-0.5	0.2	-1.1	1.0	-0.6	1.8	0.1	1.4	0.4	0.1	0.2	0.0	-1.2	-1.1	-0.5	-0.2
Leg fat mass (left)	0.7	2.9	14.4	-3.8	1.2	-0.2	0.4	-2.6	2.2	-0.1	2.5	0.9	2.1	-0.1	2.2	0.9	-0.6	-1.8	-0.6	-1.4	-1.1
Arm predicted mass (left)	0.7	3.5	10.0	-1.1	2.2	2.2	2.2	-1.8	1.9	2.0	1.2	2.6	1.8	1.2	3.2	2.2	1.2	0.7	2.2	0.8	0.8
Body Mass Index (BMI) (2010)	0.6	0.9	5.5	-1.0	0.2	-0.5	0.2	-0.7	0.3	-0.6	0.8	1.0	0.6	-0.1	0.9	0.1	-0.5	-1.3	-0.3	-1.7	-2.3
LDL Cholesterol	0.6	1.0	2.1	0.7	-1.4	-0.7	-1.1	1.5	-1.2	-0.9	-1.0	-0.9	-1.1	-1.0	0.4	-0.8	-1.0	-1.0	-0.8	-0.2	-1.2
Neuroticism (2016)	0.6	0.9	4.0	-0.4	-0.6	-1.0	-1.5	0.4	0.1	-1.1	0.7	-1.1	0.4	-0.4	-0.6	-0.7	-0.9	-1.5	-2.0	-0.8	-0.4
Schizophrenia (2014)	0.6	1.4	4.6	2.2	1.2	1.4	1.7	0.1	0.5	1.7	-0.3	1.2	0.4	1.0	1.4	1.2	0.2	-0.3	1.6	0.5	1.3
Diabetes (mother)	0.6	0.8	4.0	-1.1	-0.6	-0.1	-0.4	-0.9	0.1	-0.1	0.3	-1.1	0.0	-0.6	-0.3	0.2	-0.7	-2.0	-0.7	2.0	1.1
Severe depression (siblings)	0.6	0.7	4.1	1.0	0.0	-0.3	-0.5	-1.3	1.0	-0.4	1.2	-0.4	0.8	0.0	-0.6	0.0	-0.5	-2.0	-0.7	-0.5	0.0
Trunk fat percentage	0.6	2.6	10.1	-3.2	1.3	0.3	0.7	-2.3	2.3	0.3	2.4	1.1	2.0	0.3	2.7	1.2	0.1	-1.3	-0.2	-1.1	-0.5
Serious illness, injury or assault to yourself	0.6	0.7	2.6	-0.5	0.5	-0.0	-0.1	-1.0	0.9	-0.3	1.6	0.6	1.4	0.6	1.5	0.6	0.5	-0.9	-0.8	-0.1	0.1
Multivitamins +/- minerals	0.6	0.7	2.2	-0.1	0.5	1.2	0.6	0.4	0.5	1.1	0.1	0.7	0.4	0.4	1.5	1.0	0.9	-0.5	0.4	1.4	1.4
Body mass index (BMI)	0.6	2.5	9.9	-3.1	1.4	0.0	0.5	-2.7	2.3	0.2	2.5	1.2	2.1	0.1	2.2	1.0	-0.3	-1.1	-0.3	-0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.8	-1.7	-0.4	0.5	-0.1	2.0	-0.4	0.4	-1.0	-0.1	-0.7	-0.2	1.6	-0.1	-0.1	0.4	0.8	0.4	0.6
Hair/balding pattern: Pattern 3	0.6	0.8	7.8	1.3	0.4	0.8	0.8	-0.8	0.6	0.6	0.3	0.7	0.2	0.4	0.5	0.8	0.4	2.8	0.6	0.2	0.6
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.8	-1.1	-0.9	-1.0	-1.0	0.6	-0.5	-1.0	-0.1	-1.2	-0.3	-0.7	-0.8	-0.7	-0.7	-1.7	-1.2	-0.1	-0.6
Neck or shoulder pain in last month	0.6	0.8	3.8	0.9	0.3	-0.5	0.3	-1.9	1.2	-0.6	1.8	0.1	1.2	0.4	-0.1	0.5	-0.2	-0.9	-1.3	0.1	-0.6
Medication: Omeprazole	0.6	0.7	6.2	-2.5	-0.7	-0.5	-0.7	0.8	-0.5	-0.7	-0.5	-0.7	-0.5	-0.7	-0.4	-0.8	-0.3	-1.1	-0.6	-0.4	-0.4
Arm fat percentage (left)	0.6	2.6	8.5	-2.9	1.5	0.2	0.9	-2.3	2.3	0.4	2.4	1.4	2.0	0.2	2.8	1.2	-0.0	-1.0	0.3	-1.0	-0.7
Osteoarthritis (self-reported)	0.6	0.8	2.8	-0.3	-0.8	-1.6	-0.7	-0.5	-0.1	-1.7	0.5	-0.5	-0.0	-0.9	-0.2	-0.8	-0.8	-0.2	-1.6	-1.1	-1.3
Medication: Gliclazide	0.6	0.6	2.3	1.1	0.5	0.2	0.2	-1.5	1.0	0.1	1.3	0.8	1.0	0.2	1.2	0.6	0.6	-0.9	-0.5	-0.4	-0.5
Mother’s age at death	0.6	0.7	2.7	0.0	0.9	1.0	0.4	-0.5	0.6	1.1	0.4	0.9	0.5	0.5	0.6	0.5	0.7	0.1	1.6	1.6	1.1
Commuting to job workplace: Public transport	0.6	0.8	2.6	1.2	0.6	0.6	0.9	-0.2	0.4	1.0	0.6	1.3	0.6	0.8	1.6	0.6	1.4	0.3	0.7	0.6	0.7
Eye problems/disorders: Glaucoma	0.6	0.7	1.9	-0.2	-0.9	-0.5	-1.4	1.1	-0.7	-0.2	-0.9	-1.2	-0.6	-1.0	-0.4	-0.8	-1.0	-1.2	-1.2	-0.0	0.0
Supplements: Fish oil (including cod liver oil)	0.6	0.8	3.6	-0.3	0.5	-0.6	-0.5	-0.6	1.4	-0.6	1.9	0.7	1.4	0.7	0.8	0.0	0.1	-1.1	-0.6	-0.7	-0.9
Alcohol drinker status: Never	0.6	0.8	2.9	0.5	0.6	-0.3	0.1	-1.3	1.0	-0.6	1.7	0.5	1.4	0.4	1.3	0.3	-0.4	1.5	-0.3	-0.6	-0.5
Number of operations (self-reported)	0.6	0.9	3.5	-0.7	-0.6	-1.0	-1.1	-0.4	-0.2	-1.2	0.6	-0.6	0.1	-0.4	-0.2	-0.8	-0.0	-1.8	-1.9	-1.2	-1.2
Risk taking	0.6	0.9	4.8	-2.2	0.9	1.2	1.0	0.8	1.0	0.7	-0.1	1.1	0.4	0.8	1.4	0.9	1.0	-0.3	0.9	0.3	-0.2
Heart disease (siblings)	0.6	0.7	2.2	-1.5	-0.5	-0.9	-1.3	0.7	-0.3	-1.0	0.0	-1.1	-0.2	-0.4	-1.3	-1.0	-0.8	-1.2	-0.7	-0.0	0.2
Depression (Nagel 2018)	0.5	0.8	5.5	-2.3	-0.6	-0.7	-0.3	1.0	-0.1	-1.0	0.2	-0.7	0.1	-0.4	0.6	-0.4	-1.1	-1.1	-1.2	-0.4	0.0
Coronary Artery Disease (CAD)	0.5	0.6	1.9	1.2	-0.7	-0.6	-0.9	-1.0	-0.2	-0.9	0.1	-0.8	-0.1	-0.6	-1.4	-0.3	-0.7	-0.2	-1.1	0.9	0.9
Crohns Disease (2012)	0.5	0.8	3.1	0.0	0.2	1.3	1.2	0.7	0.0	1.2	-0.5	0.5	-0.2	0.1	1.5	1.2	0.6	1.8	1.1	1.0	0.0
HDL Cholesterol	0.5	0.9	2.8	-0.3	-1.1	-0.7	-0.7	0.7	-1.4	-0.5	-1.4	-1.2	-1.3	-1.4	-1.7	-0.7	-0.5	-0.0	-0.6	-0.2	-0.7
Smoking Status	0.5	1.1	5.0	-2.1	-0.2	-0.7	-0.5	0.4	0.0	-0.7	0.1	0.4	0.0	-0.6	0.3	-0.7	-1.1	-1.8	-0.4	-2.2	-1.7
Hearing difficulty/problems: Yes	0.5	0.8	4.1	-2.0	-0.6	0.1	-0.5	0.1	-0.2	0.1	-0.5	-1.4	-0.3	-0.5	-1.0	-0.3	-0.9	0.5	-1.2	1.5	1.2
Stomach or abdominal pain in last month	0.5	0.6	2.7	0.3	-0.2	-0.8	-0.7	-0.9	0.4	-1.1	1.1	-0.2	0.7	-0.2	-0.2	-0.3	-0.8	0.4	-1.6	-1.3	-0.5
Impedance of leg (left)	0.5	2.5	7.9	-0.3	-1.5	-1.7	-1.6	0.8	-0.8	-1.8	0.0	-2.2	-0.5	-1.0	-1.7	-1.3	-1.5	-2.4	-2.8	-2.2	-1.2
Had menopause	0.5	0.6	1.5	-0.1	-0.3	-0.3	-0.7	1.1	-0.9	-0.3	-1.0	-0.4	-1.0	-0.2	-1.1	-1.0	-0.8	-0.4	0.2	-1.2	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.5	-1.1	-0.7	-0.1	-1.0	0.6	-0.1	0.5	-0.1	-1.3	-0.1	-0.7	-1.0	0.0	-1.5	-1.3	-1.6	2.1	2.0
Financial difficulties in last 2 years	0.5	0.7	4.5	-2.1	0.6	0.3	0.6	0.7	0.8	0.4	0.3	0.6	0.4	0.1	1.4	0.3	0.0	-1.2	1.0	-1.0	0.1
Arm fat percentage (right)	0.5	2.1	7.5	-2.7	1.2	-0.1	0.6	-2.2	2.1	0.1	2.2	1.1	1.8	-0.1	2.4	0.9	-0.3	-1.3	-0.0	-1.2	-0.9
Worrier / anxious feelings	0.5	1.0	3.4	1.5	-0.8	-1.0	-1.4	-0.5	-0.7	-1.6	0.2	-1.2	-0.1	-0.7	-1.3	-0.9	-1.0	0.4	-1.8	-0.9	0.0
Asthma	0.5	1.0	9.9	-3.1	-0.4	-0.9	-0.4	-0.2	0.6	-0.8	0.3	-0.8	0.1	-0.8	-0.3	-0.3	-0.3	-1.7	-1.2	-0.2	-0.9
Pulse wave Arterial Stiffness index	0.5	0.6	3.0	-1.7	0.4	0.7	0.5	-0.2	0.9	0.9	0.5	0.4	0.6	0.7	0.6	0.7	1.0	0.1	-0.2	1.1	1.2
Breastfed as a baby	0.5	0.6	3.4	0.5	0.0	0.8	0.2	0.9	-0.4	0.8	-1.0	0.3	-0.8	0.1	-0.3	0.3	0.1	0.2	1.4	1.8	1.3
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	3.3	-0.2	0.8	1.3	1.8	-0.1	0.3	0.9	-0.2	0.9	0.2	0.5	0.9	1.3	0.8	0.7	1.2	-0.3	0.2
Glaucoma (self-reported)	0.5	0.6	2.2	-0.6	-0.7	-0.4	-1.0	1.5	-0.4	-0.1	-0.6	-0.9	-0.4	-0.7	-0.4	-0.5	-0.5	-1.4	-1.1	-0.1	-0.5
Worry too long after embarrassment	0.5	0.9	3.6	1.6	-0.3	-1.0	-0.9	-1.9	0.3	-0.9	1.1	-0.7	0.4	-0.4	-1.0	-0.5	-0.1	0.5	-1.8	-0.8	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	4.8	2.2	-0.6	0.1	-0.5	0.2	-0.9	-0.1	-1.0	-0.3	-0.9	-0.2	-1.4	-0.5	-0.2	0.8	-0.1	-0.4	-0.3
Age at first live birth	0.5	0.8	6.5	2.5	-0.0	-0.0	0.2	-0.7	-0.7	-0.3	-0.6	0.5	-0.4	-0.1	-0.6	-0.1	-0.0	2.3	0.4	-0.6	-0.5
Pulse wave peak to peak time	0.5	0.6	3.3	1.8	-0.3	-0.5	-0.3	0.2	-0.9	-0.7	-0.7	-0.2	-0.7	-0.6	-0.3	-0.6	-0.9	-0.2	0.4	-1.0	-1.1
Mouth/teeth dental problems: Loose teeth	0.5	0.6	3.9	-1.6	-0.1	-0.2	-0.4	0.4	0.2	-0.5	0.1	-0.5	0.1	-0.5	-0.5	-0.2	-0.9	-2.0	-1.5	-0.9	0.2
Medication: Ibuprofen	0.5	0.6	2.4	0.3	-0.6	-0.6	-0.5	0.0	-0.4	-0.4	-0.7	-0.3	-0.9	-1.3	0.5	-0.6	-1.4	-1.6	-0.0	-0.3	-1.0
Suffer from ‘nerves’	0.5	0.8	4.1	-0.8	-0.7	-0.9	-0.2	0.7	-0.7	-0.6	-0.4	-1.2	-0.5	-0.7	-1.0	-0.7	-0.4	2.0	-1.2	-1.0	-1.0
Chest pain or discomfort	0.5	0.8	2.1	-0.9	-0.4	-1.0	-0.8	-1.2	0.4	-1.1	0.9	-0.8	0.6	-0.7	-0.5	-0.4	-0.1	-0.9	-1.5	-1.0	-1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.0	-1.4	-0.6	-0.5	-0.8	0.3	-0.5	-0.7	-0.7	-1.2	-0.7	-0.8	-0.8	-0.6	-1.3	-0.7	-0.5	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	5.7	2.4	-0.3	0.1	-0.2	-0.6	-0.5	-0.0	-0.6	-0.5	-0.5	-0.1	-1.4	-0.1	0.2	1.1	-0.3	0.8	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.7	1.3	0.2	0.3	0.6	-0.9	1.1	0.2	1.1	-0.1	0.7	0.4	0.4	1.2	0.4	0.1	-0.9	0.9	1.0
Back pain experienced in last month	0.5	0.7	3.7	-1.9	0.4	0.0	-0.2	-0.9	1.0	0.1	1.1	0.5	1.0	0.2	0.9	0.3	-0.4	-1.6	0.1	0.3	-0.1
Hearing aid user	0.5	0.6	1.3	0.0	-0.9	-0.7	-1.0	0.2	-0.4	-0.4	-0.4	-1.1	-0.5	-0.6	-1.1	-0.7	-0.5	-0.8	-0.9	0.8	1.0
Commuting to job workplace: Cycle	0.5	0.6	3.0	1.0	-0.2	0.9	-0.3	1.7	-0.5	0.3	-0.9	-0.2	-0.6	0.2	-0.3	0.1	-0.3	1.0	0.2	1.5	1.1
Neuroticism (Nagel 2018)	0.4	1.0	4.8	0.3	-0.3	-1.3	-1.1	-1.0	0.5	-1.6	1.1	-0.5	0.5	-0.8	-0.9	-0.8	-1.0	-0.7	-2.2	-1.0	-0.4
Worry (Nagel 2018)	0.4	0.8	3.0	1.7	-0.2	-0.9	-0.9	-0.6	-0.1	-0.8	0.5	-1.1	0.0	-0.5	-1.7	-0.7	-0.8	0.7	-1.4	-0.4	0.3
Reaction Time	0.4	0.8	5.8	0.4	-0.2	-0.9	-0.1	-0.3	0.1	-1.1	0.0	-0.0	-0.1	-0.7	-0.3	-0.5	-0.9	-2.4	-1.1	-1.7	-0.7
Prostate Cancer	0.4	0.5	1.9	0.1	0.6	-0.1	1.0	-1.3	0.5	-0.0	0.9	0.6	0.7	0.6	0.8	0.6	-0.2	-0.5	-0.3	-1.4	-0.4
Age at First Birth	0.4	0.6	1.6	0.8	-0.0	0.6	0.2	0.2	-0.9	0.6	-1.3	0.3	-0.8	0.6	-1.1	-0.1	0.8	0.3	1.2	1.0	1.0
Triglycerides	0.4	0.7	3.4	-0.4	-0.5	0.5	-0.5	1.9	-0.7	0.5	-1.6	-0.4	-1.0	-0.3	-0.1	-0.6	-0.6	-0.2	1.0	0.9	0.4
Blood Eosinophil Count	0.4	3.2	12.7	-0.4	-1.5	0.1	-1.1	3.3	-1.8	0.2	-3.6	-0.8	-2.8	-2.0	-1.3	-1.2	-0.9	-0.9	1.6	2.6	1.2
Respiratory disease	0.4	0.8	4.5	-2.1	-0.7	-0.9	-0.8	0.5	0.2	-0.5	-0.2	-1.4	-0.3	-0.7	-1.3	-0.6	-0.2	-1.0	-1.1	0.2	-0.7
Chronotype (morning person)	0.4	1.0	5.2	-1.5	-0.6	-0.6	-0.5	-0.5	0.2	-1.0	0.8	-1.7	0.7	0.1	-0.6	0.0	-1.5	-2.3	-1.6	-0.1	0.2
Ever had hysterectomy (womb removed)	0.4	0.4	4.2	-2.0	0.4	0.2	-0.3	0.7	0.1	-0.1	0.2	0.2	0.1	0.1	0.1	-0.1	0.0	-1.2	-0.3	-1.0	-0.1
Vitamin and mineral supplements	0.4	0.5	4.2	1.5	0.2	-0.2	0.5	-1.0	-0.1	-0.1	-0.0	0.6	-0.1	0.3	-0.3	-0.1	0.1	2.1	0.4	-0.5	-0.9
Hand grip strength (right)	0.4	1.2	5.4	0.7	0.4	1.5	0.8	-1.3	0.3	1.4	-0.2	-0.0	0.3	0.6	0.2	1.3	0.8	1.8	0.7	2.3	1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	7.1	-0.8	-0.2	0.7	0.1	0.2	0.2	1.2	-0.2	-0.5	0.1	-0.2	-0.2	0.7	-0.7	-0.6	-0.7	2.7	2.5
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	-0.5	-0.4	-0.7	-1.0	-1.1	-0.1	-0.6	-0.0	-0.5	-0.4	-1.1	-0.9	-0.6	-1.0	0.1	-0.3	0.7	0.3
Medication: Atenolol	0.4	0.4	1.4	0.8	-0.2	-0.9	-0.6	-1.1	0.7	-0.7	1.2	-0.3	0.6	-0.3	-0.0	-0.0	-0.3	-0.6	-1.1	-0.4	-0.5
Medication: Levothyroxine sodium	0.4	0.7	8.5	-1.2	-0.4	-0.5	-0.7	0.3	-0.1	-0.4	-0.2	-0.3	-0.3	-0.7	0.3	-0.4	-0.3	-2.9	-0.2	0.5	0.1
High blood pressure (mother)	0.4	0.6	8.0	-0.6	-0.5	-0.3	-0.3	-0.8	-0.1	-0.7	0.1	-0.5	0.1	-0.2	-0.0	-0.2	-0.2	-2.8	-0.6	0.2	0.4
Diabetes (self-reported)	0.4	0.6	1.6	0.3	-1.1	-1.1	-1.0	-0.2	-0.6	-0.8	-0.3	-1.0	-0.6	-1.2	-0.1	-0.8	-0.7	-0.1	-1.3	0.5	0.2
Medication: Ramipril	0.4	0.6	1.9	-0.8	-0.2	-1.0	-0.7	-0.0	0.4	-0.9	0.7	0.2	0.2	-0.8	0.2	-0.3	-0.1	-1.4	-1.2	-1.1	-1.2
Length of working week for main job	0.4	0.4	1.4	0.7	0.0	0.5	0.6	-0.3	-0.1	0.4	-0.5	0.2	-0.4	-0.7	0.2	0.3	0.6	1.2	1.2	1.1	0.5
Hair/balding pattern: Pattern 4	0.4	1.1	3.0	-0.1	-1.2	-1.1	-0.9	1.7	-1.4	-0.7	-1.5	-1.3	-1.6	-1.0	-0.4	-1.2	-0.1	-0.8	-0.3	0.5	-0.5
Loud music exposure frequency	0.4	0.4	1.6	0.8	0.7	0.9	0.7	0.1	0.7	0.6	0.2	0.5	0.4	0.4	-0.1	0.7	0.5	-0.4	0.8	0.8	1.3
Headache pain in last month	0.4	0.6	2.2	-0.0	-0.8	-1.4	-0.7	-0.0	-0.6	-0.7	-0.5	-0.7	-0.8	-1.5	-0.2	-0.9	-1.2	-0.4	-0.9	-0.9	-0.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.6	-1.2	-0.5	0.2	-0.2	0.1	0.2	0.4	-0.4	-1.1	-0.5	-0.1	-0.5	0.1	-0.5	0.4	0.3	1.6	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.0	-0.8	-0.7	-0.1	-0.5	1.0	-0.1	0.0	-0.7	-0.7	-0.6	-0.5	-0.3	-0.3	-0.7	-1.4	-0.3	1.2	0.2
Number of children fathered	0.4	0.5	3.0	-1.7	-0.2	-0.5	-0.2	0.2	0.4	-0.6	0.5	-0.8	0.5	0.4	-1.1	-0.2	0.1	-0.8	-1.2	-0.3	-0.2
Health satisfaction	0.4	0.5	1.6	-0.5	0.4	0.5	0.4	-1.3	0.8	0.4	0.9	0.4	0.9	0.4	0.4	0.7	0.3	-1.1	-0.6	0.7	0.6
Medication: Seretide 50 evohaler	0.4	0.5	2.9	-0.7	-0.5	-0.4	-0.8	-0.0	-0.1	-0.7	-0.4	-0.8	-0.4	-0.9	-0.1	-0.6	-0.9	-1.7	-0.9	-0.3	-0.2
Had major operations	0.4	0.5	2.4	-1.6	-0.7	-0.4	-0.9	0.7	-0.7	-0.5	-0.5	-0.4	-0.6	-0.9	0.1	-0.5	0.2	-0.5	-0.1	0.9	0.4
Family relationship satisfaction	0.4	0.5	2.4	0.1	-0.2	0.5	0.4	1.2	-0.9	0.5	-1.6	0.4	-1.1	0.0	0.0	-0.2	0.2	-1.4	0.9	0.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.1	-0.1	-0.2	-1.0	-0.7	-0.8	0.3	-0.9	0.6	0.2	0.2	-0.6	0.5	-0.4	-0.4	0.3	-1.0	-1.4	-1.4
Miserableness	0.4	0.7	3.4	-1.9	-0.6	-1.1	-0.7	0.1	0.4	-1.1	0.8	-0.7	0.3	-0.8	0.5	-0.4	-0.5	-0.9	-1.3	-0.5	-0.4
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.9	-0.7	0.5	0.9	0.4	0.6	0.7	1.0	0.5	0.7	0.5	0.9	0.6	0.6	0.7	0.3	0.7	0.6	0.4
Medication: Atorvastatin	0.4	0.6	2.7	0.6	-0.9	-0.9	-0.2	-0.1	-0.9	-0.9	-0.7	-0.4	-0.8	-1.0	0.4	-0.6	0.1	1.6	-0.8	-0.0	-0.6
Alcohol drinker status: Previous	0.4	0.4	2.5	-0.9	0.1	-0.4	0.3	-0.3	0.8	-0.2	1.0	-0.2	0.7	0.6	-0.3	0.2	-0.0	-1.6	-0.9	-0.2	0.2
Ulcerative Colitis (UC)	0.3	0.5	1.7	-0.7	-0.7	-0.3	-0.5	-0.3	-0.1	-0.4	0.3	-1.3	0.0	-0.0	-1.1	-0.1	-0.9	1.2	-1.3	0.8	0.8
Fasting Glucose	0.3	0.4	2.6	0.1	0.1	0.9	0.5	-0.8	0.4	0.5	0.2	-0.2	0.1	-0.2	0.0	0.8	0.6	0.3	0.3	1.6	0.5
Lupus	0.3	0.4	2.1	1.3	0.1	0.4	0.3	0.0	-0.5	0.3	-0.9	0.4	-0.5	-0.0	0.6	-0.1	-0.5	-0.7	1.4	0.1	0.4
Primary Biliary Cirrhosis	0.3	0.4	2.0	1.4	0.1	-0.1	0.7	-1.3	0.2	-0.6	0.2	0.0	0.3	0.0	-0.6	0.1	0.7	-0.7	-0.4	-0.7	-0.8
Ulcerative Colitis	0.3	0.4	1.7	0.3	-0.0	0.7	0.7	-0.4	0.2	0.5	0.2	-0.6	0.2	0.5	-0.4	0.8	0.3	1.3	-0.3	1.3	1.2
Heel T-Score	0.3	2.2	12.0	-3.0	0.5	1.1	0.2	0.2	0.6	1.4	-0.3	-1.1	0.7	0.2	-1.0	1.1	-1.2	-0.3	-0.1	3.1	3.5
Lung FEV1/FVC ratio	0.3	1.3	5.4	0.9	0.3	0.2	0.3	0.3	-1.6	0.7	-1.5	1.5	-1.0	-0.1	0.5	-0.6	0.9	2.3	2.1	-0.9	-1.1
Medication: Co-codamol	0.3	0.4	1.0	-0.1	0.4	-0.4	0.6	-1.0	0.8	-0.3	0.9	-0.2	0.8	0.4	-0.5	0.3	0.7	0.2	-1.0	-0.6	-0.4
Townsend deprivation index at recruitment	0.3	0.4	3.0	-1.7	-0.2	-0.3	-0.4	-1.2	0.6	-0.4	0.7	-0.7	0.4	-0.5	-0.0	0.1	0.6	-0.4	-0.5	0.6	0.3
Average weekly fortified wine intake	0.3	0.4	1.2	-0.5	-0.8	0.3	-0.4	1.1	-0.7	-0.2	-1.0	-0.7	-0.8	-0.1	-0.4	-0.1	-0.7	-0.2	-0.7	0.6	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.3	2.2	-1.5	-0.6	-0.3	-0.1	0.8	-0.4	-0.4	-0.6	-0.6	-0.5	-0.7	-0.4	-0.5	-0.7	-0.4	-0.1	0.2	0.1
Relative age voice broke	0.3	0.5	2.0	-1.4	-0.3	-0.6	-1.1	-0.1	-0.1	-0.5	0.4	-0.8	0.1	-0.4	-1.2	-0.5	-0.5	-1.1	-0.7	-0.0	-0.5
Chronic bronchitis/emphysema (father)	0.3	0.3	1.8	-0.4	-0.0	-0.1	-0.5	-0.7	0.5	-0.7	0.6	0.2	0.5	-0.4	1.0	-0.0	-0.7	-1.3	-0.2	-0.3	-0.6
Nervous feelings	0.3	0.5	5.6	2.4	0.3	0.2	0.4	-0.8	0.3	0.3	0.4	-0.0	0.2	0.2	-0.3	0.3	0.0	1.3	0.1	-0.0	0.7
Hip circumference	0.3	1.2	5.6	-2.4	1.0	0.3	0.6	-1.7	1.4	0.3	1.2	1.0	1.1	-0.2	1.9	0.7	-0.7	-1.1	0.2	-0.6	-0.2
Time employed in main current job	0.3	0.4	1.5	-1.2	-0.3	0.2	-0.1	0.5	-0.4	0.4	-0.7	-0.8	-0.6	-0.5	-0.9	-0.4	-0.1	0.6	0.4	0.9	0.9
Father’s age at death	0.3	0.3	0.6	0.1	0.7	0.4	0.6	-0.7	0.6	0.3	0.8	0.8	0.8	0.4	0.7	0.5	0.5	0.8	0.6	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.5	-0.2	-1.0	-1.2	-0.6	0.0	-0.6	-0.9	-0.3	-0.5	-0.7	-1.2	-0.3	-0.9	-0.9	-0.6	-0.4	0.1	-0.3
Pulse rate	0.3	0.5	3.2	0.2	-0.3	-0.8	-1.0	0.7	-0.5	-0.7	0.1	0.2	-0.2	-0.7	-0.1	-0.7	0.1	-1.2	-0.4	-0.7	-1.8
Mouth/teeth dental problems: Dentures	0.3	0.6	1.9	-1.1	-0.0	-0.8	-1.1	-0.2	0.1	-0.2	0.7	-0.5	0.5	-0.4	-0.1	-0.5	-0.3	-0.8	-1.3	-1.4	-1.2
Lung cancer (father)	0.3	0.3	1.8	-0.3	-0.0	-0.3	0.7	-0.1	-0.5	-0.7	-0.3	-0.0	-0.1	-0.1	-0.5	0.1	-0.3	-0.2	-0.9	-1.4	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	4.9	-0.9	-0.6	-0.7	-1.2	0.4	-0.1	-0.4	-0.2	-0.4	-0.4	-1.0	-0.2	-0.5	-0.1	-2.2	-0.4	0.4	0.3
Medication: Allopurinol	0.3	0.5	3.8	-2.0	-0.3	0.6	-0.3	0.2	-0.4	0.6	-0.8	-0.5	-0.6	-0.2	-0.5	0.2	0.1	1.3	-0.3	0.1	0.1
Pulse rate, automated reading	0.3	1.0	2.3	1.3	-0.9	-0.8	-0.9	1.0	-1.5	-0.7	-1.2	-0.6	-1.2	-1.0	-0.8	-1.2	-0.5	-0.6	-0.2	-0.6	-1.5
Comparative height size at age 10	0.3	1.7	8.6	-0.1	-1.0	0.4	-0.1	2.4	-1.9	0.2	-2.9	-0.0	-2.1	-1.1	0.9	-0.7	-0.3	0.6	1.8	0.9	0.4
Age at last live birth	0.3	0.5	3.0	1.7	0.4	0.1	0.7	-0.8	-0.2	-0.0	-0.1	0.9	0.1	0.2	-0.7	0.1	0.7	1.3	0.1	-0.9	-0.5
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.1	0.4	0.4	0.3	0.5	0.9	-0.2	0.6	-0.5	0.9	-0.2	0.3	0.9	-0.2	0.2	0.2	1.1	-0.5	-0.3
Mood swings	0.3	0.6	1.8	-1.2	-0.9	-1.0	-0.4	0.7	-0.4	-0.9	-0.3	-0.8	-0.6	-1.2	-0.2	-0.6	-0.7	-0.5	-1.3	-0.5	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	3.0	-0.2	-0.1	0.4	-0.1	0.6	0.3	0.9	-0.1	0.0	0.0	0.0	0.4	0.3	0.3	0.8	0.3	1.6	1.7
Guilty feelings	0.3	0.5	1.2	-0.6	-0.4	-1.1	-0.6	-0.5	0.0	-1.0	0.3	-0.1	-0.1	-0.8	0.2	-0.9	-0.6	-0.9	-0.8	-1.1	-1.0
Ever depressed for a whole week	0.3	0.4	2.7	-0.8	0.2	0.8	0.3	0.9	0.2	0.8	-0.2	0.5	-0.0	0.3	1.6	0.3	-0.1	-0.1	0.3	-0.0	0.5
Schizophrenia (2018)	0.2	0.4	3.7	1.9	-0.1	-0.2	0.5	0.6	-0.4	0.2	-0.9	0.1	-0.6	-0.3	0.5	-0.3	-0.4	-1.0	0.3	-0.0	0.0
Alzheimer’s Disease (in mother)	0.2	0.2	1.0	-0.9	-0.3	-0.5	-0.4	-0.7	0.0	-1.0	0.5	-0.3	0.1	0.2	0.3	-0.3	-0.2	0.8	-0.5	-0.3	-0.2
Alzheimer’s Disease (including proxy)	0.2	0.3	1.3	-0.7	0.2	-0.2	-0.3	-1.1	0.6	-0.9	1.1	0.1	0.8	0.5	0.5	0.1	0.3	0.1	-0.3	-0.0	-0.2
Crohns Disease (2017)	0.2	0.5	3.8	-0.5	-0.0	0.8	0.5	0.7	-0.4	0.9	-0.9	-0.1	-0.7	-0.4	0.2	0.4	0.1	1.9	1.1	0.6	-0.0
Blood Platelet Count	0.2	2.0	5.7	-2.4	-1.3	-1.5	-1.5	-0.4	-0.6	-1.8	0.1	-2.1	-0.4	-1.5	-1.6	-1.0	-1.4	-1.8	-1.8	-1.0	-0.5
Blood Red Count	0.2	1.9	5.9	-1.1	1.7	0.7	1.1	-1.9	2.0	0.6	2.4	1.3	2.2	1.4	0.8	1.5	0.5	-0.1	-0.3	-1.0	-1.3
Hypothyroidism (self reported)	0.2	0.4	3.4	-1.0	-0.3	-0.1	-0.5	0.1	-0.1	0.1	-0.2	-0.1	-0.1	-0.7	0.3	0.1	1.0	-1.9	-0.1	0.3	0.3
Tanning	0.2	2.0	7.9	0.1	-0.8	-1.7	-0.8	0.5	-0.8	-1.9	-0.1	-1.1	-0.3	-0.8	-2.8	-1.1	-1.2	-0.6	-2.1	-2.5	-1.9
Medication for hormone replacement therapy	0.2	0.3	1.3	0.1	-0.1	-0.5	-0.3	-0.5	0.2	-0.8	0.6	-0.0	0.3	-0.4	0.5	0.1	-0.2	-0.3	-0.9	-1.1	-0.7
Mouth/teeth dental problems	0.2	0.4	2.0	1.4	0.3	0.5	0.5	-0.2	0.2	0.4	0.0	0.7	0.1	0.6	0.6	0.3	0.5	0.1	1.3	0.7	-0.1
Impedance of arm (right)	0.2	1.1	3.8	1.9	-1.1	-0.3	-0.3	2.0	-1.5	-0.4	-1.8	-0.5	-1.7	-0.5	-0.5	-0.8	0.3	-0.0	0.3	-0.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.3	0.3	-0.2	-0.5	-0.0	-0.6	0.3	-0.3	0.2	0.1	-0.1	-0.9	1.1	-0.2	-1.0	-0.9	0.2	-0.3	-0.8
Eye problems/disorders: None of the above	0.2	0.3	0.8	0.5	-0.1	-0.4	0.4	0.9	-0.6	-0.5	-0.8	0.2	-0.7	-0.2	-0.3	-0.7	-0.3	0.6	0.9	0.2	-0.1
Diabetes diagnosed by doctor	0.2	0.3	1.0	0.3	-0.8	-0.8	-0.5	-0.2	-0.5	-0.4	-0.4	-0.7	-0.6	-0.9	-0.1	-0.6	-0.3	0.0	-1.0	0.6	0.4
Irritability	0.2	0.3	2.0	-0.1	0.1	-0.2	0.5	-1.4	0.7	-0.5	0.7	0.3	0.6	-0.1	-0.0	0.4	0.0	0.6	-0.2	0.6	0.1
Fractured/broken bones in last 5 years	0.2	0.3	1.3	0.0	-0.2	0.1	0.5	0.6	-0.4	-0.1	-0.4	0.1	-0.3	0.4	0.1	0.1	1.0	1.0	0.7	-0.2	-1.1
Irritable Bowel Disease (IBD)	0.1	0.4	2.7	-0.8	-0.3	0.5	0.2	0.1	-0.2	0.5	-0.3	-0.8	-0.2	0.1	-0.4	0.5	-0.4	1.6	-0.2	0.9	0.5
Ovarian Cancer	0.1	0.2	1.1	0.4	0.3	0.2	0.8	-0.2	0.4	0.4	0.3	0.2	0.3	0.4	-0.1	0.5	0.2	1.0	0.2	-0.3	0.7
Waist Hip Ratio (WHR)	0.1	0.3	1.7	-0.6	-0.4	-0.6	-0.3	0.1	-0.1	-0.2	0.1	-0.4	-0.2	-0.2	-0.1	-0.4	-0.5	0.9	-0.3	-1.3	-0.6
Relative age of first facial hair	0.1	0.3	1.6	-0.6	0.0	-0.2	-0.3	0.6	-0.5	0.2	-0.3	-0.1	-0.4	-0.1	-1.3	-0.3	-0.3	-0.4	-0.1	-0.9	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.1	1.0	0.3	0.0	-0.2	-0.1	0.1	-0.1	-0.1	-0.1	0.1	-0.2	0.0	-0.4	-0.1	0.2	-1.0	0.3	0.1	-0.2
Hearing difficulty/problems with background noise	0.1	0.2	1.6	-1.3	0.1	0.1	0.2	-0.8	0.6	0.3	0.3	0.2	0.2	-0.4	0.4	0.2	-0.3	0.5	-0.3	0.2	-0.3
Hair/balding pattern: Pattern 2	0.1	0.2	0.7	-0.4	0.5	0.4	0.2	-0.2	0.2	0.4	0.4	0.0	0.6	0.8	-0.4	0.2	-0.2	-0.5	-0.2	-0.6	0.0
Impedance of arm (left)	0.1	0.7	2.8	1.7	-0.7	0.2	0.1	1.7	-1.0	0.2	-1.4	-0.2	-1.2	-0.0	-0.2	-0.3	0.8	0.7	0.6	-0.0	0.1
Birth weight	0.1	0.2	1.2	1.1	0.3	0.2	0.0	-0.3	0.1	0.1	0.2	0.6	0.0	0.2	0.7	0.2	-0.4	0.3	-0.1	0.2	0.7
Financial situation satisfaction	0.1	0.1	0.4	-0.6	-0.1	-0.0	0.2	0.6	0.1	0.6	-0.1	-0.0	-0.0	-0.2	-0.1	-0.0	-0.1	-0.4	-0.5	0.0	-0.5
Impedance of whole body	0.1	0.8	2.2	0.8	-1.1	-0.6	-0.7	1.5	-1.0	-0.6	-0.9	-1.3	-1.0	-0.3	-1.1	-0.8	-0.2	-0.4	-1.0	-0.8	-0.2
Hair Pigment	0.0	0.3	1.5	-0.3	0.2	-0.4	-0.4	-0.4	0.6	-0.3	1.0	0.3	0.7	0.3	-0.3	-0.1	-0.6	-1.2	-0.5	-0.4	-0.9

Hub : Genes

PPP2R2D

Models

Trait associations