Best TWAS P=1.65e-13 · Best GWAS P=5.07e-83 conditioned to 4.68e-80
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | BET1L | 0.12 | 0.08 | lasso | 2 | 0.07 | 7.3e-06 | -5.29 | -5.6 | 1.9e-08 | -0.03 | 0.12 | 0.76 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | MRPL23-AS1 | 0.36 | 0.23 | lasso | 3 | 0.21 | 3.8e-06 | -5.48 | -5.8 | 7.9e-09 | 0.03 | 0.46 | 0.05 | FALSE |
| 3 | GTEx | Brain Hippocampus | AP006621.5 | 0.26 | 0.22 | enet | 20 | 0.15 | 2.1e-04 | -3.71 | -5.2 | 1.6e-07 | 0.04 | 0.14 | 0.15 | FALSE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | MRPL23-AS1 | 0.25 | 0.07 | lasso | 5 | 0.03 | 6.8e-02 | -5.31 | -5.1 | 3.1e-07 | 0.06 | 0.11 | 0.08 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | BET1L | 0.15 | 0.09 | lasso | 5 | 0.04 | 2.3e-03 | -5.29 | -5.3 | 1.0e-07 | -0.03 | 0.09 | 0.60 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | BET1L | 0.11 | 0.04 | lasso | 2 | 0.01 | 1.9e-01 | -5.29 | -5.6 | 2.5e-08 | -0.07 | 0.03 | 0.17 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | LSP1 | 0.21 | 0.04 | enet | 28 | 0.06 | 3.4e-05 | -5.27 | -6.7 | 2.8e-11 | -0.01 | 0.66 | 0.02 | FALSE |
| 8 | GTEx | Colon Transverse | MRPL23-AS1 | 0.13 | 0.03 | enet | 19 | 0.03 | 1.0e-02 | -6.54 | -6.1 | 1.2e-09 | 0.02 | 0.12 | 0.14 | FALSE |
| 9 | GTEx | Esophagus Gastroesophageal Junction | PTDSS2 | 0.30 | 0.18 | enet | 18 | 0.17 | 8.8e-07 | -3.37 | 5.7 | 1.2e-08 | 0.09 | 0.81 | 0.03 | FALSE |
| 10 | GTEx | Esophagus Mucosa | BET1L | 0.21 | 0.12 | lasso | 2 | 0.13 | 4.8e-09 | -5.29 | -6.1 | 8.1e-10 | -0.01 | 0.13 | 0.86 | FALSE |
| 11 | GTEx | Esophagus Mucosa | MIR210HG | 0.10 | 0.00 | enet | 29 | 0.00 | 4.0e-01 | 2.12 | -5.8 | 5.0e-09 | 0.01 | 0.08 | 0.06 | TRUE |
| 12 | GTEx | Heart Left Ventricle | PTDSS2 | 0.18 | 0.02 | enet | 42 | 0.04 | 2.4e-03 | -3.37 | 6.9 | 6.0e-12 | 0.04 | 0.26 | 0.29 | TRUE |
| 13 | GTEx | Heart Left Ventricle | CHID1 | 0.24 | 0.01 | enet | 20 | 0.05 | 1.9e-03 | -2.07 | 6.3 | 3.5e-10 | 0.01 | 0.07 | 0.33 | FALSE |
| 14 | GTEx | Heart Left Ventricle | RP11-304M2.5 | 0.11 | 0.07 | lasso | 4 | 0.06 | 5.0e-04 | 4.34 | 5.8 | 8.0e-09 | 0.02 | 0.13 | 0.14 | FALSE |
| 15 | GTEx | Muscle Skeletal | HRAS | 0.09 | 0.05 | enet | 14 | 0.04 | 3.2e-05 | -3.07 | 5.3 | 1.1e-07 | 0.05 | 0.68 | 0.02 | FALSE |
| 16 | GTEx | Muscle Skeletal | BET1L | 0.15 | 0.07 | lasso | 7 | 0.04 | 4.5e-05 | -4.86 | -5.2 | 2.0e-07 | -0.05 | 0.58 | 0.42 | FALSE |
| 17 | GTEx | Ovary | TSPAN4 | 0.38 | 0.05 | enet | 55 | 0.13 | 4.9e-04 | 0.54 | -5.1 | 3.0e-07 | -0.07 | 0.05 | 0.08 | FALSE |
| 18 | GTEx | Pancreas | PSMD13 | 0.19 | 0.01 | lasso | 10 | 0.03 | 1.6e-02 | 6.15 | 6.6 | 4.2e-11 | 0.04 | 0.16 | 0.20 | TRUE |
| 19 | GTEx | Skin Not Sun Exposed Suprapubic | MRPL23-AS1 | 0.33 | 0.19 | enet | 30 | 0.21 | 9.5e-12 | -5.87 | -7.2 | 5.5e-13 | 0.07 | 1.00 | 0.00 | TRUE |
| 20 | GTEx | Skin Sun Exposed Lower leg | BET1L | 0.16 | 0.17 | enet | 7 | 0.16 | 5.3e-13 | -5.29 | -5.4 | 8.5e-08 | -0.03 | 0.12 | 0.88 | FALSE |
| 21 | GTEx | Skin Sun Exposed Lower leg | NAP1L4 | 0.13 | 0.05 | lasso | 6 | 0.03 | 1.4e-03 | 5.19 | 5.1 | 3.0e-07 | -0.02 | 0.71 | 0.02 | FALSE |
| 22 | METSIM | Adipose | CARS | 0.09 | 0.07 | enet | 11 | 0.10 | 1.4e-14 | 3.38 | 5.9 | 4.5e-09 | 0.05 | 1.00 | 0.00 | TRUE |
| 23 | METSIM | Adipose | NAP1L4 | 0.09 | 0.09 | lasso | 5 | 0.08 | 1.4e-12 | 5.18 | 5.2 | 2.7e-07 | -0.02 | 1.00 | 0.00 | FALSE |
| 24 | METSIM | Adipose | PSMD13 | 0.05 | 0.02 | lasso | 4 | 0.02 | 2.1e-03 | 6.15 | 6.1 | 8.4e-10 | 0.07 | 0.10 | 0.50 | FALSE |
| 25 | ROSMAP | Brain Pre-frontal Cortex | SIRT3 | 0.10 | 0.09 | lasso | 1 | 0.08 | 2.6e-10 | 6.15 | 6.2 | 7.5e-10 | 0.07 | 0.10 | 0.90 | FALSE |
| 26 | ROSMAP | Brain Pre-frontal Cortex | BET1L | 0.21 | 0.12 | bslmm | 272 | 0.16 | 1.5e-19 | -1.83 | 5.2 | 2.4e-07 | 0.08 | 1.00 | 0.00 | FALSE |
| 27 | The Cancer Genome Atlas | Breast Invasive Carcinoma | IGF2AS | 0.04 | 0.01 | lasso | 2 | 0.01 | 1.4e-03 | 3.09 | -7.4 | 1.7e-13 | -0.02 | 0.06 | 0.02 | TRUE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TH | 0.02 | 0.01 | enet | 11 | 0.01 | 9.8e-04 | -1.55 | -7.1 | 9.8e-13 | 0.01 | 0.15 | 0.04 | TRUE |
| 29 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LOC338651 | 0.16 | 0.06 | blup | 73 | 0.07 | 1.5e-04 | -4.42 | -5.7 | 1.4e-08 | 0.00 | 0.06 | 0.89 | FALSE |
| 30 | The Cancer Genome Atlas | Esophageal Carcinoma | MOB2 | 0.16 | 0.05 | lasso | 4 | 0.03 | 3.5e-02 | -5.80 | -5.5 | 3.9e-08 | -0.01 | 0.01 | 0.64 | FALSE |
| 31 | The Cancer Genome Atlas | Glioblastoma Multiforme | LOC338651 | 0.24 | 0.05 | blup | 73 | 0.04 | 2.9e-02 | -4.37 | -5.7 | 1.4e-08 | -0.04 | 0.01 | 0.71 | FALSE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LSP1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 5.0e-11 | 5.97 | 7.2 | 7.1e-13 | -0.03 | 0.00 | 1.00 | TRUE |
| 33 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ATHL1 | 0.08 | 0.01 | lasso | 4 | 0.02 | 4.3e-02 | 6.15 | 5.3 | 1.1e-07 | 0.08 | 0.00 | 0.51 | FALSE |
| 34 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | TMEM80 | 0.12 | 0.02 | lasso | 4 | 0.06 | 8.9e-04 | -2.07 | -5.2 | 2.6e-07 | -0.04 | 0.02 | 0.47 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Adenocarcinoma | MOB2 | 0.02 | 0.01 | blup | 35 | 0.02 | 2.9e-03 | -5.80 | -5.3 | 1.1e-07 | -0.01 | 0.00 | 0.95 | FALSE |
| 36 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MOB2 | 0.08 | 0.05 | blup | 35 | 0.10 | 1.1e-10 | -4.86 | 5.7 | 1.2e-08 | 0.00 | 0.01 | 0.99 | TRUE |
| 37 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | MUC6 | 0.26 | 0.00 | enet | 9 | 0.03 | 5.1e-02 | 2.35 | -5.3 | 1.4e-07 | -0.03 | 0.01 | 0.42 | TRUE |