Best TWAS P=1.83e-14 · Best GWAS P=1.24e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | ARAP1 | 0.27 | 0.25 | lasso | 5 | 0.26 | 2.6e-17 | 5.2 | 5.6 | 2.1e-08 | 0.54 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Esophagus Mucosa | ARAP1-AS2 | 0.12 | 0.08 | lasso | 6 | 0.08 | 3.1e-06 | 5.2 | 5.5 | 3.0e-08 | 0.53 | 0.42 | 0.22 | FALSE |
| 3 | GTEx | Esophagus Mucosa | ARAP1-AS1 | 0.15 | 0.12 | enet | 7 | 0.13 | 4.1e-09 | 5.2 | 5.4 | 7.7e-08 | 0.52 | 0.99 | 0.00 | FALSE |
| 4 | GTEx | Pituitary | PDE2A | 0.25 | 0.19 | lasso | 5 | 0.17 | 4.1e-05 | 7.6 | 7.6 | 4.2e-14 | 0.99 | 0.00 | 0.96 | FALSE |
| 5 | GTEx | Pituitary | RP11-169D4.2 | 0.19 | 0.20 | lasso | 2 | 0.16 | 7.3e-05 | 7.6 | 7.7 | 1.8e-14 | 0.99 | 0.01 | 0.95 | TRUE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | ARAP1 | 0.24 | 0.20 | lasso | 4 | 0.16 | 3.6e-09 | 5.2 | 5.5 | 3.4e-08 | 0.55 | 0.99 | 0.00 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | ARAP1-AS2 | 0.20 | 0.08 | lasso | 5 | 0.05 | 1.5e-03 | 4.4 | 5.2 | 2.2e-07 | 0.59 | 0.37 | 0.40 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | ARAP1-AS1 | 0.14 | 0.13 | lasso | 4 | 0.07 | 9.1e-05 | 5.2 | 5.2 | 1.7e-07 | 0.60 | 0.36 | 0.61 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | ARAP1 | 0.21 | 0.13 | lasso | 7 | 0.13 | 1.2e-10 | 5.2 | 5.6 | 2.8e-08 | 0.51 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | ARAP1-AS1 | 0.18 | 0.07 | lasso | 7 | 0.06 | 1.0e-05 | 5.2 | 5.4 | 6.8e-08 | 0.52 | 0.84 | 0.01 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PDE2A | 0.02 | 0.02 | lasso | 2 | 0.02 | 2.0e-04 | 7.6 | -7.6 | 2.3e-14 | -0.99 | 0.00 | 0.99 | FALSE |