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chr11:84,642,072-86,688,920

Best TWAS P=5.69e-17 · Best GWAS P=8.84e-18 conditioned to 0.0319

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TMEM126B	0.03	0.02	bslmm	349	0.02	8.1e-04	6.7	-5.5	4.3e-08	0.52	0.45	0.08	FALSE
2	GTEx	Artery Aorta	TMEM126A	0.13	0.11	lasso	7	0.13	1.4e-07	-6.7	5.6	2.6e-08	-0.42	0.92	0.01	FALSE
3	GTEx	Artery Tibial	SYTL2	0.08	0.00	enet	17	0.00	4.2e-01	-6.1	6.2	4.4e-10	-0.51	0.16	0.04	FALSE
4	GTEx	Cells Transformed fibroblasts	SYTL2	0.14	0.03	lasso	5	0.05	1.1e-04	-8.6	8.4	5.7e-17	-0.94	0.01	0.99	TRUE
5	GTEx	Cells Transformed fibroblasts	CCDC89	0.06	0.07	lasso	4	0.05	8.3e-05	-7.2	-6.7	1.7e-11	0.76	0.45	0.40	FALSE
6	GTEx	Muscle Skeletal	SYTL2	0.10	0.11	lasso	5	0.10	2.2e-10	-6.8	7.6	3.0e-14	-0.80	0.86	0.14	FALSE
7	GTEx	Nerve Tibial	SYTL2	0.05	0.03	enet	9	0.02	2.4e-02	-7.9	7.7	1.1e-14	-0.90	0.02	0.96	FALSE
8	METSIM	Adipose	PICALM	0.06	0.04	enet	26	0.05	1.7e-07	-4.8	-5.5	4.5e-08	0.51	0.94	0.06	FALSE
9	NTR	Blood	PICALM	0.02	0.01	blup	501	0.01	3.2e-05	-5.2	-5.6	1.8e-08	0.46	0.96	0.01	FALSE
10	YFS	Blood	EED	0.07	0.09	enet	16	0.09	4.1e-27	-5.7	-5.9	4.6e-09	-0.05	1.00	0.00	TRUE
11	YFS	Blood	SYTL2	0.36	0.27	bslmm	411	0.32	2.1e-107	-7.4	6.7	2.1e-11	-0.76	0.93	0.07	FALSE
12	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SYTL2	0.04	0.03	lasso	4	0.03	1.9e-04	-7.9	8.0	8.7e-16	-0.90	0.02	0.98	FALSE
13	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf73	0.04	0.00	blup	65	0.01	4.9e-02	4.2	-5.5	3.1e-08	-0.05	0.01	0.51	FALSE
14	The Cancer Genome Atlas	Brain Lower Grade Glioma	PICALM	0.04	0.01	blup	87	0.02	1.9e-03	4.7	6.0	2.1e-09	-0.29	0.04	0.76	TRUE
15	The Cancer Genome Atlas	Lung Adenocarcinoma	SYTL2	0.01	0.03	lasso	3	0.02	6.3e-04	-7.5	7.5	4.8e-14	-0.79	0.08	0.61	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	CCDC83	0.06	0.00	blup	79	0.03	4.0e-04	-3.1	-7.5	9.2e-14	0.60	0.01	0.33	FALSE