TWAS hub - PICALM

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.1217	0.0461	1.5e-03	0.075	NA	0.095	NA	0.087	5.3e-06	NA	3.2e-07	NA	1.0e-06
2	GTEx	Skin Not Sun Exposed Suprapubic	0.1010	0.0450	4.6e-03	0.022	NA	0.014	NA	0.001	2.1e-02	NA	5.5e-02	NA	2.6e-01
3	GTEx	Skin Sun Exposed Lower leg	0.1010	0.0380	6.0e-04	0.057	NA	0.056	NA	0.075	1.6e-05	NA	1.9e-05	NA	8.2e-07
4	METSIM	Adipose	0.0617	0.0203	1.1e-06	0.039	0.042	0.046	0.044	0.044	1.5e-06	6.1e-07	1.7e-07	3.0e-07	3.3e-07
5	NTR	Blood	0.0173	0.0069	9.5e-04	0.011	0.013	0.012	0.012	0.013	1.4e-04	3.3e-05	4.6e-05	5.8e-05	3.9e-05
6	TCGA	Brain Lower Grade Glioma	0.0376	0.0202	1.3e-03	0.007	0.021	0.010	NA	0.010	5.1e-02	1.9e-03	2.3e-02	NA	2.1e-02
7	TCGA	Lung Adenocarcinoma	0.0516	0.0313	5.7e-03	0.003	0.007	0.000	NA	-0.002	1.3e-01	5.0e-02	3.5e-01	NA	5.8e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Alzheimer’s Disease (including proxy)	18.4	26.7	93.3	3.1	3.9	3.3	0.8	7.5	-9.7	-1.1
Alzheimer’s Disease (in father)	11.7	12.7	35.8	2.6	3.6	2.7	1.6	4.6	-6.0	-1.5
Breastfed as a baby	5.3	6.6	8.3	-2.5	-2.7	-2.5	-2.9	-2.7	2.2	2.5
Knee pain experienced in last month	4.8	7.4	13.6	2.6	2.8	2.6	2.1	3.1	-3.7	-1.7
Medication: Aspirin	3.9	5.1	17.7	-0.1	4.2	-0.0	0.9	3.4	-2.4	-0.0
Blood Platelet Count	3.8	43.8	88.0	5.0	7.2	4.8	3.8	7.8	-9.4	-6.5
Hand grip strength (right)	3.8	10.4	13.5	-3.1	-1.9	-3.0	-3.4	-3.7	3.6	3.5
Alzheimer’s Disease (in mother)	3.7	4.3	15.2	1.8	1.0	1.6	0.2	2.8	-3.9	-0.5
Angina	3.6	4.7	8.6	1.0	2.9	1.0	1.9	2.6	-2.4	-2.4
Serious illness, injury or assault to yourself	3.6	4.3	8.0	2.8	1.7	2.3	1.9	1.9	-2.1	-1.5
Chronic bronchitis/emphysema (father)	3.4	4.0	9.5	-1.3	-2.0	-1.1	-1.0	-3.1	3.1	1.3
Angina (self-reported)	3.4	4.4	8.5	0.9	2.9	1.0	1.8	2.6	-2.4	-2.2
Medication: Aspirin	3.4	4.4	16.4	0.5	4.0	0.3	1.1	3.0	-2.0	-0.1
Hand grip strength (left)	3.3	8.7	13.2	-2.6	-2.3	-2.4	-2.7	-3.5	3.6	3.3
Supplements: Glucosamine	3.3	4.3	9.2	2.2	1.4	2.6	3.0	2.4	-1.3	-0.4
Medication for pain relief, constipation, heartburn	3.3	5.6	18.9	-1.3	-4.3	-1.4	-1.5	-3.0	2.3	0.3
Illnesses of siblings	3.2	4.6	10.0	-2.5	-3.2	-2.2	-1.8	-1.4	1.9	1.4
Falls in the last year	3.2	4.3	7.9	2.8	2.7	2.3	1.2	2.1	-1.9	-0.2
Relative age voice broke	3.1	4.8	7.8	-2.4	-2.4	-2.5	-1.3	-2.5	2.8	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.1	3.6	8.2	1.6	2.9	1.5	0.8	1.8	-2.6	-1.3
Relative age of first facial hair	3.0	6.2	12.2	-2.3	-2.4	-2.9	-1.9	-2.8	3.5	-0.0
Sitting height	2.8	19.6	30.1	-4.0	-4.3	-4.6	-5.5	-4.8	4.4	3.1
Depression (self-reported)	2.8	3.4	6.0	2.1	1.7	2.1	2.1	2.4	-1.1	0.2
Leg pain on walking	2.8	3.5	5.3	1.9	2.2	1.4	1.6	2.0	-2.3	-1.6
Number of treatments/medications taken	2.6	4.7	12.3	1.0	3.5	1.0	2.0	3.0	-1.7	-1.5
Average weekly red wine intake	2.6	3.8	8.1	-2.4	-1.4	-2.2	-1.2	-1.9	2.8	1.0
Verbal and Numeric Reasoning (VNR)	2.5	6.1	8.6	2.4	1.9	2.6	2.9	2.7	-2.7	-1.7
Ever unenthusiastic/disinterested for a whole week	2.5	3.0	9.2	1.4	3.0	1.2	1.0	1.9	-1.8	-1.0
Time employed in main current job	2.5	2.9	6.9	-1.2	-2.6	-1.3	-0.7	-2.2	2.2	-0.3
Mean time to correctly identify matches	2.5	4.8	13.2	2.3	1.6	2.2	3.6	1.6	-0.6	-2.3
Medication: Cholesterol lowering	2.4	3.7	9.9	0.7	3.1	0.3	1.2	1.3	-2.0	-2.9
Medication: Paracetamol	2.3	3.6	7.5	1.5	2.7	1.5	1.7	2.4	-1.6	-1.4
Waist Hip Ratio (WHR)	2.2	10.1	16.5	3.0	4.1	3.2	3.3	2.5	-3.4	-2.4
Depression (Nagel 2018)	2.1	3.2	7.2	1.8	1.9	2.2	2.7	1.5	-1.1	-0.5
Body Mass Index (BMI) (2010)	2.1	2.9	6.7	-1.6	-1.1	-2.0	-1.4	-2.6	1.9	-0.5
HbA1C	2.1	2.4	8.8	0.6	3.0	1.1	0.5	1.3	-2.0	-0.5
Chronic bronchitis/emphysema (mother)	2.0	2.3	4.0	-2.0	-0.4	-1.8	-1.4	-1.3	1.2	1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	5.2	-2.3	-1.4	-2.1	-1.3	-0.7	1.5	0.7
Lupus	1.9	2.8	5.9	1.4	2.4	1.5	0.9	1.0	-2.1	-1.9
Ever used hormone-replacement therapy (HRT)	1.9	2.4	8.3	-0.1	2.9	0.2	0.8	1.8	-0.9	1.9
Medication: Simvastatin	1.9	2.8	7.8	1.6	2.0	1.0	0.9	0.9	-1.6	-2.8
High blood pressure (siblings)	1.9	2.7	5.4	1.9	2.3	1.7	2.0	1.3	-0.9	-0.9
Medication: Atorvastatin	1.9	2.4	7.6	-2.7	-0.0	-2.6	-1.3	-0.1	0.1	0.6
Alcohol drinker status: Never	1.9	2.3	4.2	1.2	1.5	1.4	1.3	1.7	-2.0	-1.2
Average weekly fortified wine intake	1.8	2.1	5.5	1.8	0.4	1.9	-0.2	1.2	-2.3	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.8	3.0	5.8	1.1	2.4	1.5	1.9	2.4	-1.6	-0.1
Health satisfaction	1.8	2.4	8.0	1.3	1.1	0.8	1.8	0.8	-1.2	-2.8
High cholesterol (Self-reported)	1.8	3.3	11.9	0.9	3.5	0.8	0.9	1.5	-1.9	-1.7
Illnesses of father: Heart disease	1.7	2.3	4.9	1.3	2.2	1.9	1.7	0.7	-0.2	-1.5
Eye problems/disorders: Glaucoma	1.7	2.0	5.9	-0.9	-1.3	-1.1	-2.4	0.1	-1.9	-0.9
Age started oral contraceptive pill	1.7	2.2	4.5	2.1	1.7	1.7	1.4	1.5	-0.5	-0.6
Mean Putamen Volume	1.6	1.9	6.2	0.4	2.5	0.7	1.9	1.4	-0.8	0.4
Tinnitus: Yes, but not now, but have in the past	1.6	1.7	3.9	-1.2	-0.4	-1.7	-2.0	-1.9	0.4	0.2
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.9	-0.1	1.9	0.4	0.1	2.4	-1.5	1.4
Mouth/teeth dental problems: Loose teeth	1.6	1.9	5.4	-1.6	0.5	-1.9	-2.3	-0.1	-1.2	-0.0
Supplements: Fish oil (including cod liver oil)	1.6	2.1	6.9	-0.8	-0.2	-0.7	0.2	-1.0	2.6	2.3
Heart disease (siblings)	1.6	2.0	5.1	1.1	2.2	1.0	0.8	1.2	-1.7	-1.3
Ever had hysterectomy (womb removed)	1.5	1.7	2.4	1.6	1.4	1.2	1.0	1.1	-1.2	-1.5
Medication: Metformin	1.5	2.2	5.1	-2.3	-0.5	-2.2	-1.3	-1.3	0.8	-0.8
Neuroticism score	1.5	3.1	4.9	1.9	1.7	1.9	2.2	1.4	0.4	2.1
Standing height	1.5	14.6	24.0	-3.0	-3.1	-3.8	-4.9	-4.3	3.8	3.5
Peak expiratory flow (PEF)	1.5	3.6	11.7	-1.4	-2.5	-1.9	-3.4	-1.2	0.3	-0.2
Medication: Ibuprofen	1.5	1.8	5.6	0.1	1.8	0.6	0.6	2.4	-1.5	0.9
Unable to work because of sickness or disability	1.5	2.0	5.1	1.6	0.4	1.4	1.6	2.2	-1.1	0.6
Chronotype (morning person)	1.4	3.1	8.1	-1.4	-0.4	-2.0	-2.6	-2.8	0.9	-0.1
Severe depression (siblings)	1.4	1.5	4.4	0.9	2.1	1.0	1.8	1.0	-0.1	0.2
Arm fat percentage (right)	1.4	5.4	12.9	1.9	3.2	1.0	1.7	0.5	-2.7	-3.6
Pulse rate	1.4	2.3	4.2	1.3	0.8	1.2	1.7	1.4	-1.8	-2.1
Loud music exposure frequency	1.4	1.6	2.9	-1.2	-1.7	-1.2	-0.3	-1.7	1.5	-0.2
Comparative height size at age 10	1.4	7.7	12.6	-2.2	-1.5	-2.8	-3.5	-3.1	2.4	3.3
Alcohol drinker status: Previous	1.4	1.6	5.1	-1.1	0.3	-1.9	-2.3	0.0	-0.7	0.8
Major Depression (MDD)	1.3	1.6	6.1	0.8	1.3	0.8	2.5	0.8	1.0	0.0
Coronary Artery Disease (CAD)	1.3	1.6	5.6	0.7	2.4	0.7	0.7	0.0	-1.8	-0.6
Blood Red Count	1.3	12.1	25.7	4.2	2.5	3.5	2.9	2.1	-3.2	-5.1
Neuroticism	1.3	3.2	5.1	2.1	1.9	2.0	2.3	1.0	0.7	2.0
Forced vital capacity (FVC), Best measure	1.3	4.7	7.2	-2.2	-1.3	-2.3	-2.7	-1.8	2.4	2.2
Emphysema/chronic bronchitis	1.3	1.5	6.0	-0.1	-0.5	-0.3	0.7	-0.9	2.4	1.6
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	5.7	-0.7	-0.9	-0.7	0.0	-1.9	2.4	-0.3
Arm fat percentage (left)	1.3	5.2	13.3	1.9	2.9	1.1	1.6	0.4	-2.7	-3.6
Mood swings	1.3	2.3	6.1	0.9	2.1	1.3	2.5	0.7	0.7	1.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	-2.0	-0.9	-1.4	-0.5	-1.0	0.8	0.9
Neuroticism (Nagel 2018)	1.2	2.8	6.8	1.9	1.9	1.9	2.6	1.0	0.7	1.1
Worry (Nagel 2018)	1.2	2.6	5.4	1.2	0.3	1.4	2.0	0.1	2.3	2.3
Height	1.2	22.5	35.9	-2.8	-4.1	-4.0	-5.5	-5.6	6.0	4.4
Hypothyroidism (self reported)	1.2	2.8	7.7	-1.4	2.8	-1.1	-0.6	2.5	-1.5	0.2
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	5.7	0.3	1.6	0.3	1.0	2.4	-1.3	-0.1
Fluid intelligence score	1.2	2.4	4.9	1.4	1.4	1.8	2.2	1.7	-1.1	-0.6
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	8.5	0.1	-2.9	0.2	-1.2	-1.1	0.5	1.6
Hypothyroidism/myxoedema (self-reported)	1.2	2.3	6.7	-1.4	2.6	-1.1	-0.5	2.3	-0.8	0.4
Birth weight	1.2	2.5	6.1	-0.7	-1.0	-1.3	-2.5	-2.2	1.1	1.5
Medication: Seretide 50 evohaler	1.2	1.3	4.3	-0.1	2.1	0.0	0.9	1.0	-1.3	-1.3
Alcohol intake frequency.	1.2	2.8	5.6	-0.7	1.6	-1.3	-2.4	1.6	-2.4	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	2.9	1.1	1.7	1.5	1.6	0.9	-0.9	0.1
Mineral and other dietary supplements	1.2	1.7	3.7	-0.9	-0.4	-1.0	-1.9	-0.7	-1.8	-1.5
Ever taken oral contraceptive pill	1.2	1.3	3.1	-1.8	-0.0	-1.4	-1.3	0.8	-1.3	-0.0
Depressed Affect (Nagel 2018)	1.1	2.4	5.2	1.7	2.3	1.6	2.0	1.2	-0.4	-0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	4.9	0.9	0.3	0.9	0.7	-0.8	-0.8	-2.2
Supplements: Zinc	1.1	1.2	2.6	-0.0	1.2	0.1	0.8	1.1	1.6	1.6
Fed-up feelings	1.1	1.9	4.4	1.6	2.1	1.2	1.1	1.6	-1.0	0.1
Taking other prescription medications	1.1	1.6	5.2	0.1	1.8	-0.2	0.5	2.3	-1.3	-0.9
Medication: Levothyroxine sodium	1.1	1.9	6.4	-0.4	2.5	-0.3	0.1	2.3	-1.1	0.1
Had menopause	1.1	1.4	4.4	1.1	2.1	0.7	0.9	1.3	-1.1	0.3
Financial difficulties in last 2 years	1.1	1.5	5.6	0.4	0.8	0.3	0.0	1.7	-2.4	-0.9
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.8	0.8	0.9	1.5	1.7	1.6	-0.8	-0.7
Trunk fat-free mass	1.1	6.4	10.6	-2.5	-0.9	-3.0	-2.8	-3.2	2.4	2.1
Alcohol intake versus 10 years previously	1.1	1.7	3.6	-1.5	0.8	-1.9	-1.9	0.2	-0.7	1.0
Trunk predicted mass	1.1	6.2	10.2	-2.4	-0.9	-3.0	-2.8	-3.2	2.3	2.1
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.4	-1.1	1.6	-1.2	-1.4	0.1	-1.2	-0.4
Glaucoma (self-reported)	1.1	1.3	3.0	0.4	-1.6	0.0	-1.2	0.5	-1.4	-1.7
Pulse wave peak to peak time	1.1	1.3	2.3	-1.5	-1.2	-1.4	-1.3	-0.5	1.2	-0.2
Pulse rate, automated reading	1.1	3.5	7.3	2.7	0.3	2.4	1.8	1.5	-1.9	-1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.9	1.2	0.7	1.6	1.7	1.1	-0.3	0.1
Diabetes diagnosed by doctor	1.1	1.8	3.0	-1.7	-0.6	-1.7	0.1	-1.6	1.1	-1.7
Ever smoked	1.1	1.9	6.2	-0.8	-0.8	-0.7	1.4	-1.4	2.5	1.1
Arm fat-free mass (left)	1.1	5.5	10.8	-2.2	-0.1	-3.0	-2.9	-3.3	1.6	1.7
Average weekly beer plus cider intake	1.1	1.5	6.8	-0.4	-2.6	-0.4	-0.4	-0.7	1.5	0.9
Irritability	1.1	1.9	5.1	1.0	1.8	0.8	1.5	0.8	0.8	2.3
Fasting Glucose	1.0	1.2	3.0	0.6	0.3	0.9	1.7	0.7	-0.8	-1.7
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.6	0.8	0.9	1.3	1.4	1.9	-0.6	1.1
Medication: Co-codamol	1.0	1.1	2.9	0.8	1.7	1.1	1.2	1.1	-0.6	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	4.4	0.4	2.1	0.3	0.6	1.2	-1.6	0.2
Hayfever, allergic rhinitis or eczema	1.0	2.2	3.4	1.4	0.8	1.7	1.8	1.2	-1.8	-1.5
Nervous feelings	1.0	1.8	4.4	1.7	0.0	1.7	2.1	-0.0	1.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	4.6	0.3	1.6	0.2	0.7	2.1	-1.7	-0.2
Mouth/teeth dental problems	1.0	1.5	2.1	-1.1	-1.5	-1.1	-1.4	-0.6	1.2	1.4
Lung cancer (father)	1.0	1.1	3.2	1.8	0.0	1.6	1.2	-0.0	-0.9	-0.4
Arm fat-free mass (right)	1.0	5.0	9.3	-2.0	-0.3	-2.7	-2.9	-3.0	1.6	2.0
Neck or shoulder pain in last month	1.0	1.4	2.9	-0.0	1.6	0.1	0.2	1.1	-1.7	-1.6
Mouth/teeth dental problems: Mouth ulcers	1.0	1.6	2.5	1.4	0.1	1.3	1.3	1.5	-1.0	-1.6
Supplements: Calcium	1.0	1.2	3.1	0.9	0.3	0.7	1.8	0.4	1.2	1.4
Arm predicted mass (left)	1.0	4.9	9.7	-2.1	0.0	-2.9	-2.8	-3.1	1.4	1.6
Bipolar Disorder (2018)	0.9	1.4	5.9	-0.8	-0.0	-0.1	0.4	-0.3	1.7	2.4
Intelligence (Savage-Jansen 2018)	0.9	2.7	4.4	1.6	0.4	1.6	2.1	1.8	-1.6	-1.8
Reaction Time	0.9	1.7	4.8	1.1	0.2	1.0	2.2	0.8	0.1	-2.0
Allergy or Eczema	0.9	2.3	4.5	0.8	1.7	1.5	1.8	1.2	-2.1	-1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	4.2	0.4	2.0	0.2	-0.1	1.0	-1.3	0.5
Pain all over the body in last month	0.9	0.9	2.4	-0.1	1.6	0.5	1.0	0.8	0.1	1.5
Medication: Ramipril	0.9	1.1	1.9	-0.9	-0.3	-1.3	-1.4	-1.3	0.0	-1.4
Worrier / anxious feelings	0.9	1.6	3.0	1.5	1.1	1.4	1.4	0.7	0.6	1.7
Tense / ‘highly strung’	0.9	1.5	3.8	0.6	1.0	0.7	1.6	0.7	1.2	2.0
Exposure to tobacco smoke outside home	0.9	1.2	2.7	-1.6	-1.0	-1.6	-1.1	-0.4	0.9	0.4
Arm predicted mass (right)	0.9	4.7	8.2	-2.0	-0.1	-2.6	-2.7	-2.9	1.6	2.0
Smoking status: Previous	0.9	1.4	3.7	-1.9	1.2	-1.6	0.4	0.1	0.8	0.9
Risk taking	0.9	1.2	2.5	-1.6	0.6	-1.5	-1.5	-0.1	-0.2	1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.2	3.8	-2.0	0.7	-1.7	-0.6	0.8	-0.4	0.1
Prostate Cancer	0.8	1.1	3.5	-0.8	-1.0	-0.4	-0.6	-1.4	1.9	0.3
Trunk fat percentage	0.8	3.4	7.5	1.4	2.7	0.4	0.4	-0.1	-2.5	-2.7
Diabetes (self-reported)	0.8	1.2	3.0	-1.7	-0.4	-1.6	-0.2	-1.1	0.9	-0.8
Father’s age at death	0.8	1.1	1.9	-1.2	-1.4	-1.0	-0.2	-1.1	1.3	-0.8
Hair/balding pattern: Pattern 3	0.8	1.1	2.9	1.1	-1.3	0.8	1.1	-0.2	0.6	-1.7
Pulse wave Arterial Stiffness index	0.8	1.0	1.6	1.3	1.2	1.1	1.0	0.2	-1.0	0.5
Exposure to tobacco smoke at home	0.8	0.9	2.3	-1.1	-1.0	-1.5	-1.1	-0.5	-0.2	-0.4
Medication: Paracetamol	0.8	1.3	4.2	0.8	2.1	0.6	0.6	1.5	-0.8	-0.7
Body fat percentage	0.8	3.4	9.7	1.3	3.1	0.4	0.8	-0.0	-2.3	-2.5
Number of full brothers	0.8	1.0	3.9	-0.2	-0.2	-0.5	-1.4	-0.0	0.6	2.0
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.6	-0.3	0.7	-0.3	-0.7	1.1	-1.9	-0.6
Whole body fat-free mass	0.8	4.5	9.9	-1.8	-0.6	-2.6	-2.4	-3.1	1.9	1.4
Ever had bowel cancer screening	0.8	1.0	3.2	-1.0	-0.4	-1.8	-0.9	-0.0	0.8	1.1
Eye problems/disorders: Cataract	0.8	0.9	2.8	1.0	1.7	0.8	0.8	0.9	-0.2	-0.6
Medication for cholesterol	0.8	1.3	3.2	1.5	-0.9	1.8	0.9	-1.1	0.7	-0.2
Osteoporosis (self-reported)	0.8	1.0	1.9	1.4	0.8	0.7	0.8	1.1	-0.9	-1.3
Whole body water mass	0.8	4.3	10.0	-1.8	-0.6	-2.5	-2.4	-3.2	1.7	1.3
Average weekly champagne plus white wine intake	0.8	1.1	4.2	-0.6	0.5	-0.9	-0.9	0.1	-1.0	-2.0
Commuting to job workplace: Public transport	0.8	1.0	3.1	0.0	-1.1	-0.1	0.1	-0.8	1.8	1.4
Commuting to job workplace: Cycle	0.8	1.0	2.5	0.7	1.6	0.9	0.9	1.0	0.2	1.2
Crohns Disease (2017)	0.7	1.5	2.7	1.2	1.4	1.6	1.5	1.0	-0.4	0.7
Bipolar Disorder (2011)	0.7	0.6	1.7	0.8	1.0	1.3	0.7	0.3	-0.1	0.7
Schizophrenia (2014)	0.7	1.5	4.3	1.0	0.6	1.5	2.1	0.0	1.5	0.9
Average weekly spirits intake	0.7	0.8	1.6	-1.3	-0.3	-0.9	-0.4	-0.9	-0.9	-1.2
Medication for hormone replacement therapy	0.7	0.7	2.5	-0.6	1.6	-0.0	0.1	0.4	-1.2	0.8
Qualifications: CSEs or equivalent	0.7	0.9	2.0	1.3	0.5	1.3	-0.3	0.1	-1.4	0.5
Past tobacco smoking	0.7	1.2	2.1	1.4	-1.0	1.1	-1.3	0.1	-1.2	-1.2
Heart attack	0.7	0.9	3.0	-1.7	0.4	-1.6	-0.7	0.6	-0.3	-0.1
Medication: Amlodipine	0.7	1.0	2.3	-0.9	1.3	-1.2	-0.8	1.5	-0.6	-0.1
Comparative body size at age 10	0.7	1.9	2.6	1.5	1.1	1.1	1.2	-1.6	1.4	-1.6
Number of children fathered	0.7	0.8	2.2	-1.1	0.8	-0.7	-1.5	-0.4	-0.6	0.6
Illnesses of siblings: Diabetes	0.7	0.9	2.5	1.6	0.8	1.3	0.8	-0.3	-0.2	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	3.6	-1.2	-1.2	-1.2	-1.9	-1.4	0.6	0.6
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.3	0.7	0.2	0.8	0.6	0.8	-1.1	-1.5
Back pain experienced in last month	0.7	1.0	3.0	-0.5	-0.3	-0.6	-1.0	-1.7	1.2	0.7
Breast cancer (self-reported)	0.7	0.8	1.8	1.4	0.9	1.0	0.6	1.2	-0.3	-0.3
Guilty feelings	0.7	1.0	2.6	1.1	0.3	1.0	1.5	-0.2	1.6	0.5
Tinnitus: Yes, now most or all of the time	0.7	0.8	3.0	0.4	-1.4	0.3	0.3	-0.1	-0.5	-1.7
Medication: Blood pressure	0.7	1.2	4.3	-1.2	-0.4	-2.1	-1.5	-0.1	0.6	0.0
Illnesses of father: High blood pressure	0.7	0.8	3.8	0.4	-0.1	0.1	0.1	-1.0	1.9	0.9
Leg fat percentage (left)	0.7	2.4	9.7	0.8	3.1	0.2	0.8	-0.0	-1.8	-1.6
Bipolar Disorder or Schizophrenia	0.6	1.6	4.3	0.1	0.3	0.9	1.4	-0.3	1.9	2.1
Respiratory disease	0.6	1.3	4.9	-0.4	-0.3	-0.0	1.3	-1.3	2.2	0.4
Vitamin and mineral supplements	0.6	0.8	2.4	1.1	0.4	0.7	-0.0	-1.5	-0.2	-1.1
Maternal smoking around birth	0.6	0.8	2.3	-0.5	1.5	-0.6	-0.9	0.2	-0.8	1.2
Medication: Lansoprazole	0.6	0.7	1.8	-0.4	-1.2	-0.5	-0.1	-0.9	1.3	-0.1
Birth weight of first child	0.6	1.2	2.1	1.2	0.3	1.3	1.3	0.8	-0.7	-1.4
Medication: Omeprazole	0.6	0.7	1.3	1.1	0.8	0.9	1.1	0.4	0.5	1.0
Suffer from ‘nerves’	0.6	1.0	3.3	0.3	-0.2	0.8	1.2	0.2	1.1	1.8
Family relationship satisfaction	0.6	0.8	1.8	-1.3	-0.1	-1.2	-0.9	-0.7	0.9	-0.3
Smoking status: Current	0.6	0.9	3.5	0.5	1.0	0.8	1.9	0.8	-0.6	0.5
Miserableness	0.6	1.1	2.4	1.1	1.5	0.6	0.8	1.3	-1.0	-0.9
Hearing aid user	0.6	0.7	1.4	0.1	1.0	0.4	0.6	1.2	-0.8	1.0
Medication: Bendroflumethiazide	0.6	1.0	1.9	-1.1	0.3	-1.4	-0.3	0.6	1.3	1.1
Basal metabolic rate	0.6	3.4	9.0	-1.5	-0.1	-2.4	-2.2	-3.0	1.3	0.8
Number of operations (self-reported)	0.6	0.9	2.5	-0.5	0.9	-0.3	0.0	1.6	-0.9	1.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	2.6	0.5	0.7	0.4	0.7	-0.0	1.2	1.6
Age at First Birth	0.5	0.7	2.8	0.7	-1.7	0.1	-0.4	0.9	-0.2	-0.7
Crohns Disease (2012)	0.5	0.8	2.4	1.0	0.4	1.5	1.3	0.2	-0.1	-0.3
BMI	0.5	2.7	8.6	0.8	2.9	0.1	0.4	-0.1	-2.3	-2.1
Cardiovascular Disease	0.5	1.5	5.6	1.0	2.4	0.6	1.7	0.9	-0.1	-0.2
Type 2 Diabetes (T2D) (2018)	0.5	0.9	5.1	-0.5	0.4	-0.4	0.8	-0.4	-0.4	-2.3
Townsend deprivation index at recruitment	0.5	0.7	1.9	0.7	0.7	0.1	0.6	1.0	-0.7	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	4.8	0.1	-0.2	0.7	1.2	1.1	0.2	2.2
Multivitamins +/- minerals	0.5	0.7	2.3	-0.7	-0.8	-0.3	0.2	0.8	0.7	1.5
Stomach or abdominal pain in last month	0.5	0.6	1.2	0.8	0.5	1.0	0.8	-0.5	0.4	-1.1
High blood pressure (mother)	0.5	0.7	3.0	0.2	-0.8	-0.0	0.6	-0.6	1.7	0.6
Body mass index (BMI)	0.5	2.0	6.2	0.5	2.5	-0.2	0.5	-0.5	-1.7	-2.1
Trunk fat mass	0.5	2.0	5.4	0.7	2.3	-0.4	-0.3	-0.9	-1.8	-2.1
Waist circumference	0.5	1.7	6.5	0.4	2.5	-0.2	0.7	-0.4	-1.5	-1.7
Number of incorrect matches in round	0.5	0.8	2.2	-0.6	1.0	-0.3	1.5	1.3	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	4.2	-0.1	0.4	0.5	1.2	1.4	-0.3	2.0
Number of live births	0.5	0.7	1.5	-1.2	0.1	-1.2	-0.8	0.3	-1.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	5.2	-1.0	-0.7	-1.3	-2.3	-0.7	0.7	1.4
Arm fat mass (right)	0.5	2.0	5.4	0.6	2.1	-0.4	0.0	-0.8	-1.7	-2.3
Leg fat percentage (right)	0.5	1.9	8.4	0.6	2.9	0.1	0.8	-0.2	-1.5	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.1	0.5	1.0	0.3	1.5	0.6	0.2	0.8
Age at first live birth	0.5	0.9	2.9	-0.4	-1.4	-0.0	0.3	-0.9	1.7	-0.7
Medication: Blood pressure	0.5	0.9	3.6	-0.8	1.9	-0.8	0.5	0.8	0.5	-0.4
Number of full sisters	0.5	0.7	2.2	-0.0	-1.5	-0.4	-1.1	-0.8	0.2	0.6
Overall health rating	0.5	1.1	3.8	0.9	2.0	0.6	1.1	1.2	-0.6	0.2
Had major operations	0.5	0.6	1.2	0.7	0.4	0.9	0.8	1.1	-0.8	0.5
Pain type(s) experienced in last month: Hip pain	0.5	0.6	2.8	0.4	1.7	-0.0	0.1	0.6	-0.4	0.8
Myopia	0.5	0.7	2.2	1.1	0.2	1.1	0.6	1.5	-0.0	-0.1
Pain experienced in last month	0.5	0.8	3.0	-0.9	-1.7	-0.8	-0.1	-0.8	0.5	-0.4
Pack years of smoking	0.5	0.7	1.5	1.2	0.3	0.8	0.9	0.8	-0.9	-0.5
Schizophrenia (2018)	0.4	0.9	2.1	0.8	0.5	1.2	1.4	-0.2	1.1	0.7
Ovarian Cancer	0.4	0.5	1.2	-0.8	0.3	-0.8	-0.7	-0.8	-0.4	-1.1
Primary Biliary Cirrhosis	0.4	0.6	1.7	0.4	0.1	0.3	-0.4	1.3	-1.0	0.8
Smoking Status	0.4	1.0	3.2	-0.5	1.8	-0.3	1.8	0.2	-0.6	-0.2
Lung FEV1/FVC ratio	0.4	2.1	6.6	1.8	0.3	0.6	-1.2	1.2	-2.6	-1.2
Sensitivity / hurt feelings	0.4	0.8	2.4	0.3	1.5	0.4	0.4	1.3	-0.5	0.7
Leg fat-free mass (left)	0.4	1.9	7.3	-0.6	-0.2	-1.5	-1.5	-2.7	0.8	-0.1
Current tobacco smoking	0.4	0.7	2.6	0.4	1.0	0.5	1.6	0.6	-0.6	0.1
Medication: Atenolol	0.4	0.5	1.2	-1.1	0.6	-1.1	-0.7	0.4	-0.4	-0.0
Forced vital capacity (FVC)	0.4	1.7	3.3	-1.3	-0.4	-1.3	-1.8	-0.5	1.4	1.8
Qualifications: None of the above	0.4	0.8	1.6	-1.1	0.2	-1.3	-1.2	-0.5	-0.3	1.1
Weight	0.4	1.7	5.3	-0.6	1.1	-1.6	-1.4	-2.3	-0.1	-0.6
Asthma	0.4	0.8	2.3	-0.7	-0.9	-0.5	0.6	-1.3	1.5	-0.2
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.4	0.1	0.9	-0.2	-0.3	-1.0	0.0	-1.2
Wheeze or whistling in the chest in last year	0.4	0.6	2.2	1.0	0.8	0.3	1.5	0.6	0.2	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.5	-0.1	-1.2	-0.0	-0.0	0.2	0.1	-1.2
Shortness of breath walking on level ground	0.4	0.5	2.0	0.1	1.0	-0.3	0.6	0.0	-0.1	-1.4
Qualifications: College or University degree	0.4	1.3	5.3	-0.5	-1.6	-0.6	0.3	-0.5	2.3	0.2
Eye problems/disorders: None of the above	0.4	0.5	2.1	-0.4	-0.7	-0.3	-0.5	-0.5	0.3	1.5
Heart disease (mother)	0.4	0.4	1.0	1.0	0.6	0.8	1.0	0.4	0.2	0.3
Whole body fat mass	0.4	1.8	6.2	0.6	2.5	-0.4	-0.2	-0.9	-1.6	-1.7
Leg fat mass (right)	0.4	1.5	6.2	0.5	2.5	-0.3	0.1	-1.0	-1.3	-1.1
Chest pain or discomfort	0.4	0.6	1.0	1.0	1.0	0.1	0.3	1.0	-0.8	-0.6
Supplements: Vitamin C	0.4	0.5	1.3	-1.1	0.2	-0.6	-0.0	1.2	-0.6	-0.2
Long-standing illness, disability or infirmity	0.4	0.6	1.1	-0.6	1.1	-0.6	0.2	1.0	-0.7	0.8
Medication: Gliclazide	0.4	0.5	0.9	-1.0	-0.6	-0.9	-0.8	-0.2	-0.6	-0.5
Leg predicted mass (right)	0.4	1.9	6.6	-0.6	-0.1	-1.6	-1.8	-2.6	0.7	-0.2
Arm fat mass (left)	0.4	1.8	4.9	0.5	2.1	-0.5	-0.1	-0.8	-1.6	-2.2
Wears glasses or contact lenses	0.4	0.5	1.5	-0.5	1.2	-0.7	-0.6	0.6	-0.7	0.0
Mother’s age at death	0.4	0.5	1.3	-0.3	-1.0	0.2	0.7	0.3	0.8	1.1
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.9	0.4	-0.7	-0.8	-1.0	0.2	0.6
Leg fat mass (left)	0.4	1.6	6.2	0.6	2.5	-0.3	0.0	-1.0	-1.4	-1.3
Neuroticism (2016)	0.3	0.5	1.6	-0.0	1.3	0.2	0.8	0.6	0.4	0.8
Triglycerides	0.3	0.5	1.2	-0.0	-0.3	-0.1	1.1	-0.9	1.0	-0.4
Diabetes (father)	0.3	0.4	0.6	0.7	0.8	0.4	0.8	0.6	-0.3	-0.8
Diabetes (mother)	0.3	0.4	0.8	0.5	-0.1	0.4	0.9	0.8	0.5	0.6
Impedance of leg (right)	0.3	1.3	4.5	-1.4	-0.6	-0.7	-1.0	0.2	0.8	2.1
Age when periods started (menarche)	0.3	0.7	2.2	-0.3	-1.5	-0.5	-0.4	-0.9	0.5	-1.0
Leg predicted mass (left)	0.3	1.8	6.8	-0.6	-0.1	-1.5	-1.6	-2.6	0.7	-0.1
Alcohol usually taken with meals	0.3	0.5	2.2	-0.3	0.3	-0.5	-1.5	0.1	-0.7	0.5
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	0.2	0.6	0.5	0.0	0.9	-0.4	1.0
Hip circumference	0.3	1.4	2.8	-1.0	1.1	-1.7	-1.3	-1.6	-0.2	-0.9
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	4.8	-0.1	-0.6	-0.7	-2.2	-0.0	-0.1	0.8
Noisy workplace	0.3	0.3	1.0	-0.3	0.3	-0.5	-1.0	-0.1	0.3	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	0.7	-0.0	0.7	0.7	-0.1	-0.6	-0.5
Mouth/teeth dental problems: Dentures	0.3	0.5	1.1	0.5	1.0	0.8	1.0	0.1	-0.7	0.2
Illnesses of mother	0.3	0.3	0.7	-0.6	-0.5	-0.5	-0.3	-0.8	0.7	-0.3
Impedance of arm (left)	0.3	1.4	2.3	1.3	-0.9	1.2	0.4	1.4	-1.1	-1.5
Length of working week for main job	0.3	0.3	0.9	-0.1	0.6	0.3	0.0	-0.3	-0.8	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	-0.4	0.5	-0.4	0.5	0.8	0.3	1.2
Hair/balding pattern: Pattern 4	0.3	0.7	2.8	-0.2	-1.7	-0.1	-0.8	-0.9	0.4	0.7
Pulse wave reflection index	0.3	0.4	1.5	0.5	0.3	0.7	0.7	0.2	-0.3	1.2
Worry too long after embarrassment	0.3	0.6	1.0	0.8	0.3	0.9	0.4	-0.4	1.0	1.0
Age at last live birth	0.3	0.4	1.1	-0.5	-1.0	-0.4	0.5	0.2	0.6	-0.8
Hypertension (Self-reported)	0.3	0.8	1.9	-0.6	1.4	-1.0	-0.2	-0.2	1.2	0.7
Leg fat-free mass (right)	0.3	1.9	6.7	-0.6	-0.2	-1.6	-1.7	-2.6	0.7	-0.2
Friendships satisfaction	0.3	0.3	0.8	-0.6	0.9	-0.2	-0.3	-0.5	0.7	0.5
Asthma (self-reported)	0.3	0.7	2.1	-0.4	-0.7	-0.2	1.0	-1.0	1.4	0.1
Osteoarthritis (self-reported)	0.3	0.4	1.0	0.9	-0.1	0.8	1.0	0.0	0.2	0.1
Number of self-reported non-cancer illnesses	0.3	0.6	2.5	-0.3	1.6	-0.7	0.4	0.4	0.7	-0.0
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.1	-0.1	-0.4	-0.2	-0.1	-1.0	0.6	-0.6
Ever depressed for a whole week	0.3	0.3	1.3	-0.6	0.2	-0.6	0.3	-0.5	1.1	0.3
Cholesterol lowering medication	0.3	0.4	1.1	-0.2	1.1	-0.3	0.1	1.0	-0.5	0.0
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	1.2	-0.2	0.9	-0.2	-0.6	0.5	-1.1	-0.5
Irritable Bowel Disease (IBD)	0.2	0.5	1.2	0.5	0.4	1.0	1.1	0.7	0.2	0.7
LDL Cholesterol	0.2	0.4	0.8	0.9	0.6	0.5	0.2	-0.1	-0.9	-0.6
Rheumatoid Arthritis	0.2	0.3	0.8	0.7	0.2	0.5	0.9	0.6	-0.4	0.4
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.7	-0.0	0.1	0.5	0.8	-0.1	-0.3	-0.4
Ulcerative Colitis	0.2	0.3	1.2	-0.4	-1.1	-0.0	-0.4	0.3	0.1	0.3
Blood White Count	0.2	1.4	3.3	0.1	-0.7	-0.8	-1.5	-0.8	-1.6	-1.8
Heel T-Score	0.2	1.8	4.7	-2.2	-0.9	-1.2	-0.8	0.7	0.0	2.1
Systolic Blood Pressure	0.2	0.9	3.8	-0.6	-1.0	-0.6	0.2	-0.8	2.0	-0.1
Lung FVC	0.2	1.2	3.6	-0.2	1.9	0.4	0.4	1.5	0.1	1.6
Systolic blood pressure, automated reading	0.2	0.5	1.0	-0.5	1.0	-0.8	-0.2	-0.5	1.0	0.7
Pack years adult smoking proportion	0.2	0.3	0.6	0.8	-0.1	0.3	0.5	0.1	-0.7	-0.7
High blood pressure	0.2	0.5	1.5	-0.2	1.1	-0.8	-0.2	-0.3	1.2	0.4
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.5	-0.6	0.1	-0.3	-0.5	0.6	0.2
Impedance of leg (left)	0.2	1.1	3.6	-1.3	-0.2	-0.6	-1.3	0.5	0.3	1.9
Had other major operations	0.2	0.2	0.5	-0.3	0.3	-0.6	-0.4	0.2	-0.4	0.7
Allergy	0.2	0.4	1.5	-0.5	0.1	-0.6	-1.2	0.1	0.3	0.7
Impedance of arm (right)	0.2	1.1	2.5	1.0	-0.7	0.9	0.4	1.3	-1.0	-1.6
Happiness	0.2	0.2	0.5	-0.5	-0.5	-0.3	-0.1	-0.6	0.7	-0.2
Prospective memory result	0.2	0.3	0.5	0.4	0.5	0.5	0.3	0.6	-0.7	0.6
Blood clot in the leg (DVT)	0.2	0.2	0.5	-0.2	0.6	-0.2	-0.5	0.2	-0.7	-0.4
Gout (self-reported)	0.2	0.3	1.7	-0.2	0.4	-0.3	0.5	-0.2	0.4	-1.3
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	-0.9	0.2	-0.7	0.4	-0.4	0.2	-0.5
Migraine (self-reported)	0.2	0.3	1.1	-0.2	0.4	0.1	0.2	1.0	-0.8	0.2
Loneliness, isolation	0.2	0.3	1.2	0.1	1.1	0.1	0.9	0.1	0.2	0.3
Commuting to job workplace: Walk	0.2	0.2	0.9	0.4	-0.9	0.3	0.1	-0.0	0.6	0.4
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	-0.0	-0.4	-0.2	-0.4	0.5	-1.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	1.2	1.1	0.4	0.9	-0.3	-0.1	0.0	0.4
Financial situation satisfaction	0.2	0.3	1.2	0.2	0.8	0.2	0.2	0.1	0.0	1.1
Medication: Lisinopril	0.2	0.3	0.7	0.5	0.5	0.5	0.8	-0.4	0.1	-0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.7	0.5	0.4	0.1	-0.5	-0.8	0.0	0.6
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	-0.3	0.1	-0.4	0.0	0.7	-0.7	-0.2
Ulcerative Colitis (UC)	0.1	0.3	0.8	-0.0	0.3	0.4	0.9	0.7	0.4	0.2
Breast Cancer	0.1	0.3	1.5	0.1	0.8	0.2	-0.0	0.1	0.2	1.2
HDL Cholesterol	0.1	0.2	0.9	0.1	-0.3	0.4	-0.2	0.1	0.6	1.0
Blood Eosinophil Count	0.1	1.0	2.4	-0.8	-1.0	-1.0	-0.6	0.1	-1.1	-1.6
Hearing difficulty/problems: Yes	0.1	0.2	0.6	-0.2	-0.8	-0.4	-0.2	0.3	-0.1	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.7	0.1	-0.8	0.7	0.7	0.3	0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.5	-0.1	-0.7	0.1	-0.0	0.1	-0.2	-0.0
Headache pain in last month	0.1	0.2	0.6	-0.1	0.2	-0.3	-0.3	0.7	-0.6	-0.8
Medication: Allopurinol	0.1	0.2	1.1	0.2	0.4	0.0	0.1	0.0	-0.3	-1.1
Qualifications: nursing, teaching	0.1	0.2	0.5	-0.0	-0.7	0.0	-0.6	0.5	-0.1	0.4
Diastolic blood pressure, automated reading	0.1	0.5	1.0	-0.3	-0.4	-0.8	-1.0	-0.4	0.3	1.0
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.9	-0.2	-1.4	0.4	-0.2	-0.2	-0.4	0.5
Impedance of whole body	0.1	0.3	0.9	0.2	-0.6	0.4	-0.5	1.0	-0.4	-0.0
Hair Pigment	0.0	1.2	2.8	-1.4	-0.4	-1.2	-0.4	-1.3	0.4	-1.7
Tanning	0.0	0.6	1.0	0.3	1.0	0.5	0.9	1.0	-0.9	-0.2
Hearing difficulty/problems with background noise	0.0	0.1	0.2	-0.1	-0.1	-0.3	0.4	0.1	0.3	-0.4

Hub : Genes

PICALM

Models

Trait associations