Hub : Genes

TMEM126B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.033 0.016 0.0043 0.022 0.022 0.022 0.022 0.019 0.00082 0.00088 0.00097 0.00081 0.0021
2 TCGA Testicular Germ Cell Tumors 0.188 0.112 0.0046 0.056 0.071 0.031 NA 0.038 0.00470 0.00170 0.02900 NA 0.0170

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.9 1.4 2.4 -1.5 -0.7
Bipolar Disorder or Schizophrenia 0.6 1.5 3.1 -1.8 0.0
Depressed Affect (Nagel 2018) 0.6 1.2 2.0 -0.6 -1.4
Depression (Nagel 2018) 0.8 1.2 2.3 -1.5 -0.1
Intelligence (Savage-Jansen 2018) 0.4 1.1 1.8 1.3 -0.6
Neuroticism (Nagel 2018) 0.9 2.0 4.1 -0.1 -2.0
Schizophrenia (2018) 0.3 0.7 1.0 -1.0 0.5
Schizophrenia vs Biploar Disorder 2.0 2.7 5.1 2.3 -0.4
Worry (Nagel 2018) 0.8 1.6 1.8 1.2 -1.3
Alzheimer’s Disease (in mother) 0.1 0.1 0.1 -0.4 0.2
Alzheimer’s Disease (in father) 0.9 1.0 1.5 -1.2 -0.7
Alzheimer’s Disease (including proxy) 0.5 0.7 0.8 -0.9 -0.8
Crohns Disease (2017) 0.2 0.5 0.6 -0.8 0.6
Irritable Bowel Disease (IBD) 0.3 0.7 1.3 0.4 -1.2
Ulcerative Colitis (UC) 1.8 3.3 5.3 1.1 -2.3
Major Depression (MDD) 2.6 3.2 6.4 -0.1 -2.5
Reaction Time 0.6 1.2 2.4 1.6 -0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.6 0.1 -1.3
Breast Cancer 0.7 1.8 3.0 -1.7 0.7
Ovarian Cancer 0.8 1.0 2.0 0.0 1.4
Prostate Cancer 0.1 0.1 0.2 0.4 -0.4
Age at First Birth 4.7 6.8 10.2 3.2 -1.8
Bipolar Disorder (2011) 0.9 0.9 1.8 -1.3 -0.0
Body Mass Index (BMI) (2010) 0.3 0.3 0.7 0.2 0.8
Coronary Artery Disease (CAD) 0.8 0.9 1.4 -1.2 0.7
Crohns Disease (2012) 0.3 0.5 0.7 0.5 0.9
Mean Putamen Volume 0.9 1.0 1.1 -1.1 -1.0
Fasting Glucose 1.7 2.1 2.8 1.7 -1.2
HbA1C 0.4 0.4 0.8 -0.9 0.3
HDL Cholesterol 0.3 0.4 0.5 0.7 -0.6
LDL Cholesterol 0.2 0.3 0.4 -0.4 0.6
Lupus 0.1 0.1 0.2 -0.4 0.2
Neuroticism (2016) 0.4 0.6 1.1 0.3 -1.0
Primary Biliary Cirrhosis 0.3 0.5 0.8 -0.5 -0.9
Rheumatoid Arthritis 1.1 1.6 2.6 -1.6 0.7
Schizophrenia (2014) 0.1 0.1 0.3 -0.1 -0.5
Triglycerides 0.4 0.7 1.3 1.1 -0.4
Type 2 Diabetes (T2D) (2012) 0.1 0.1 0.2 0.1 0.4
Ulcerative Colitis 1.7 2.5 3.4 1.3 -1.8
Blood Eosinophil Count 0.1 0.4 0.5 0.7 0.7
Blood Platelet Count 0.4 4.4 7.5 1.1 -2.7
Blood Red Count 0.1 0.9 1.1 1.1 -0.9
Blood White Count 0.3 2.2 3.4 -1.0 1.8
Heel T-Score 1.0 7.6 12.3 3.5 -1.7
BMI 0.7 4.0 4.8 -2.2 1.8
Height 1.1 21.7 30.0 -5.5 3.6
Waist Hip Ratio (WHR) 0.2 0.9 1.0 -0.8 1.0
Systolic Blood Pressure 1.0 5.0 6.7 2.6 -1.8
Smoking Status 0.6 1.5 2.9 0.3 -1.7
Allergy or Eczema 1.0 2.5 4.7 0.6 2.2
Cardiovascular Disease 0.2 0.7 1.1 1.0 -0.5
Hypothyroidism (self reported) 1.0 2.3 2.6 1.4 -1.6
Respiratory disease 1.7 3.9 4.3 2.1 -1.9
Type 2 Diabetes (T2D) (2018) 1.4 2.6 4.2 2.1 1.0
Lung FEV1/FVC ratio 0.6 2.9 3.8 -2.0 1.4
Lung FVC 0.2 1.0 1.5 0.8 -1.2
Neuroticism 0.4 0.9 1.7 -0.4 -1.3
Chronotype (morning person) 2.6 6.1 7.2 -2.7 2.2
Hair Pigment 0.0 0.6 1.1 1.0 0.3
Tanning 0.2 2.7 3.2 1.8 -1.5
Hand grip strength (left) 0.0 0.1 0.1 -0.2 0.3
Number of treatments/medications taken 2.7 4.9 6.3 2.5 -1.9
Average weekly spirits intake 1.1 1.3 1.9 -0.9 1.4
Sensitivity / hurt feelings 0.4 0.8 1.4 0.4 -1.2
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.0 0.0 -1.0
Hearing difficulty/problems: Yes 1.3 2.1 2.4 1.3 -1.6
Relative age of first facial hair 1.7 3.6 5.1 2.3 -1.4
Other serious medical condition/disability diagnosed by doctor 1.1 1.5 2.6 0.6 -1.6
Ever used hormone-replacement therapy (HRT) 1.6 2.0 3.1 -1.0 -1.8
Ever had hysterectomy (womb removed) 0.1 0.2 0.2 0.4 0.3
Systolic blood pressure, automated reading 0.4 1.0 2.0 0.3 -1.4
Eye problems/disorders: Diabetes related eye disease 2.1 2.3 4.0 -0.8 2.0
Angina 1.6 2.0 2.9 1.1 -1.7
Medication for hormone replacement therapy 3.1 3.5 6.6 -2.6 0.6
Vitamin and mineral supplements 2.6 3.6 4.1 -2.0 1.8
Supplements: Zinc 2.1 2.3 3.3 1.1 -1.8
Medication: Co-codamol 0.4 0.5 1.0 0.2 -1.0
Medication: Metformin 1.1 1.5 2.1 1.5 1.0
Diabetes (father) 0.4 0.5 0.8 -0.3 -0.9
Diabetes (mother) 0.7 0.9 0.9 0.9 -0.9
Severe depression (siblings) 0.2 0.3 0.5 0.7 -0.2
Pack years adult smoking proportion 0.5 0.8 0.9 -0.9 0.8
Impedance of leg (right) 0.0 0.1 0.2 0.1 0.5
Leg fat-free mass (left) 1.2 6.6 9.5 -3.1 1.9
Trunk fat percentage 1.8 7.2 8.5 -2.9 2.4
Hand grip strength (right) 0.1 0.3 0.5 -0.0 0.7
Townsend deprivation index at recruitment 1.2 1.7 2.7 1.6 -0.8
Current tobacco smoking 0.2 0.4 0.8 -0.9 -0.0
Average weekly fortified wine intake 2.0 2.3 2.9 -1.7 1.3
Maternal smoking around birth 0.2 0.3 0.5 -0.7 0.4
Fed-up feelings 0.7 1.2 1.4 -1.2 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.3 -1.2 -0.0
Relative age voice broke 2.7 4.2 7.6 2.8 -0.9
Taking other prescription medications 0.8 1.2 2.3 1.5 -0.4
Age when periods started (menarche) 0.7 1.8 2.8 0.8 -1.7
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 1.0 -1.0 0.4
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.5 2.2 1.5 -0.9
Tinnitus: Yes, but not now, but have in the past 2.3 2.4 3.5 -1.9 1.2
Qualifications: CSEs or equivalent 3.2 4.3 6.2 -2.5 1.5
Serious illness, injury or assault to yourself 0.1 0.1 0.3 0.5 0.0
High blood pressure 0.0 0.1 0.2 0.5 -0.2
Hayfever, allergic rhinitis or eczema 0.6 1.3 1.8 0.9 1.3
Multivitamins +/- minerals 1.2 1.5 1.6 1.2 -1.3
Stomach or abdominal pain in last month 0.6 0.7 0.9 0.7 0.9
Supplements: Glucosamine 4.6 6.0 11.0 3.3 -1.1
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 0.6 0.6 -0.8
Medication: Atenolol 0.6 0.8 1.4 1.2 -0.4
Medication: Levothyroxine sodium 0.8 1.4 1.9 1.0 -1.4
Sitting height 0.7 5.1 5.6 -2.4 2.1
Chronic bronchitis/emphysema (father) 2.8 3.3 4.9 -1.3 2.2
High blood pressure (mother) 0.9 1.2 2.1 0.6 -1.5
Body mass index (BMI) 0.5 2.1 3.0 -1.7 1.1
Impedance of leg (left) 0.0 0.2 0.4 -0.3 0.6
Leg predicted mass (left) 1.2 6.6 9.7 -3.1 1.9
Trunk fat mass 2.0 8.7 10.9 -3.3 2.5
Waist circumference 0.7 2.7 3.8 -2.0 1.3
Number of incorrect matches in round 4.1 6.8 10.0 3.2 -1.9
Past tobacco smoking 3.2 5.9 9.4 -1.5 3.1
Alcohol usually taken with meals 0.1 0.1 0.2 -0.4 -0.0
Nervous feelings 0.5 0.9 1.8 1.3 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.4 0.7 0.4 -0.9
Hearing difficulty/problems with background noise 0.7 1.1 1.8 1.4 -0.7
Hair/balding pattern: Pattern 2 0.4 0.5 1.0 -1.0 -0.3
Had menopause 0.2 0.2 0.5 -0.7 -0.1
Had other major operations 0.9 1.1 1.9 0.6 1.4
Forced vital capacity (FVC) 0.0 0.0 0.0 0.1 0.1
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 2.8 1.7 -1.4
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.1 1.0 -0.3
Qualifications: None of the above 1.1 2.3 2.6 -1.6 1.4
Financial difficulties in last 2 years 0.4 0.5 1.0 1.0 -0.1
Mouth/teeth dental problems 0.7 1.1 2.1 0.2 1.5
Heart attack 1.5 1.9 2.2 1.2 -1.5
Allergy 0.1 0.3 0.6 -0.8 -0.2
Pain all over the body in last month 0.7 0.7 1.3 -1.1 0.4
Diabetes (self-reported) 0.4 0.6 0.9 1.0 0.6
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 0.8 0.8 0.9
Medication: Ramipril 0.1 0.1 0.1 0.1 0.4
Medication: Simvastatin 0.6 0.9 1.5 1.2 0.6
Fluid intelligence score 0.1 0.3 0.5 0.1 -0.7
Illnesses of siblings 0.1 0.2 0.3 0.5 -0.2
Neuroticism score 0.8 1.7 3.2 -0.5 -1.8
Weight 1.8 9.0 12.8 -3.6 2.3
Impedance of arm (right) 0.1 0.3 0.4 0.6 -0.5
Arm fat percentage (right) 0.5 1.9 2.2 -1.5 1.2
Trunk fat-free mass 0.8 4.4 6.4 -2.5 1.6
Hip circumference 0.8 3.4 5.0 -2.2 1.4
Time employed in main current job 0.2 0.3 0.5 0.1 0.7
Alcohol intake versus 10 years previously 1.8 2.7 3.6 -1.3 1.9
Father’s age at death 0.3 0.3 0.7 0.8 -0.1
Worrier / anxious feelings 1.1 2.0 2.7 -1.1 -1.6
Frequency of tiredness / lethargy in last 2 weeks 0.6 0.9 1.8 -1.4 -0.1
Falls in the last year 1.5 2.0 3.9 -2.0 -0.1
Hair/balding pattern: Pattern 3 0.9 1.3 1.4 1.2 -1.1
Number of live births 0.5 0.7 1.0 0.6 -1.0
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 1.0 -0.6 1.0
Pulse rate 0.0 0.1 0.1 0.4 0.2
Happiness 0.1 0.2 0.3 -0.5 -0.2
Noisy workplace 0.0 0.0 0.0 0.1 -0.2
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.0 1.0 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.1 0.2 0.3 -0.4
Mouth/teeth dental problems: Dentures 0.4 0.7 1.4 -0.2 -1.2
Asthma 2.4 4.7 5.5 2.4 -1.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.6 0.2 -1.2
Medication: Cholesterol lowering 0.4 0.6 0.7 0.8 -0.6
Depression (self-reported) 0.7 0.8 1.6 -0.0 -1.3
Medication: Lansoprazole 0.7 0.8 1.0 1.0 -0.7
Prospective memory result 0.5 0.6 1.1 0.3 1.0
Lung cancer (father) 0.7 0.8 1.1 -0.6 1.1
Illnesses of mother 0.5 0.6 1.2 -0.1 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.4 0.5 -0.7 0.6
Pulse wave Arterial Stiffness index 1.9 2.2 4.3 -2.1 0.4
Impedance of arm (left) 0.1 0.3 0.4 0.7 -0.3
Arm fat mass (right) 1.1 4.6 6.2 -2.5 1.7
Trunk predicted mass 0.8 4.5 6.5 -2.5 1.6
Standing height 1.3 13.4 18.0 -4.2 3.0
Length of working week for main job 6.7 7.4 12.0 -1.7 3.5
Exposure to tobacco smoke at home 1.0 1.1 1.7 1.3 -0.7
Breastfed as a baby 0.3 0.4 0.5 -0.7 0.5
Tense / ‘highly strung’ 2.1 3.5 6.5 0.8 -2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 1.0 1.3 0.8 -1.1
Hair/balding pattern: Pattern 4 0.2 0.5 0.6 -0.8 0.6
Birth weight of first child 0.1 0.1 0.1 0.4 -0.2
Peak expiratory flow (PEF) 0.2 0.4 0.6 0.3 0.8
Pulse wave reflection index 0.6 0.7 0.8 -0.8 -0.9
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.4 -0.2 -0.6
Loud music exposure frequency 0.4 0.5 0.9 0.9 0.2
Qualifications: O levels/GCSEs or equivalent 0.1 0.2 0.3 0.6 -0.1
Mouth/teeth dental problems: Bleeding gums 2.3 2.9 5.6 -2.4 0.5
Blood clot in the leg (DVT) 1.4 1.8 2.8 -1.7 0.9
Medication: Paracetamol 0.5 0.8 1.5 -0.3 -1.2
Headache pain in last month 0.8 1.4 2.9 1.7 -0.0
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 2.1 -1.1 1.5
Glaucoma (self-reported) 1.3 1.5 2.9 0.3 1.7
Gout (self-reported) 0.2 0.3 0.3 0.5 -0.5
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 1.4 1.2 -1.2
Medication: Amlodipine 3.1 4.3 4.4 2.1 -2.1
Medication: Ventolin 100micrograms inhaler 0.6 0.7 0.8 0.8 -0.9
Birth weight 2.7 5.9 7.0 -2.6 2.2
Chronic bronchitis/emphysema (mother) 0.0 0.1 0.1 -0.0 0.3
High blood pressure (siblings) 0.0 0.0 0.0 -0.1 -0.2
Forced vital capacity (FVC), Best measure 0.0 0.2 0.3 -0.2 0.5
Body fat percentage 1.3 5.3 6.2 -2.5 2.1
Leg fat percentage (right) 0.7 2.6 2.6 -1.6 1.6
Arm fat-free mass (right) 1.6 8.3 12.2 -3.5 2.1
Exposure to tobacco smoke outside home 0.3 0.3 0.6 0.2 -0.8
Comparative body size at age 10 0.2 0.4 0.8 -0.9 -0.1
Number of full brothers 0.0 0.0 0.0 0.0 -0.0
Worry too long after embarrassment 1.0 1.7 3.3 -1.8 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.0 0.0 0.0 -0.2 0.2
Wheeze or whistling in the chest in last year 0.9 1.6 3.0 0.4 -1.7
Number of children fathered 0.0 0.0 0.1 -0.3 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 0.9 0.9 0.9
Age at first live birth 0.9 1.6 2.5 0.8 -1.6
Pulse wave peak to peak time 1.0 1.2 2.4 1.5 -0.1
Health satisfaction 0.8 1.0 1.8 1.3 0.5
Shortness of breath walking on level ground 0.7 0.8 1.5 0.4 -1.2
Qualifications: College or University degree 2.3 7.4 7.5 2.7 -2.7
Eye problems/disorders: None of the above 0.0 0.0 0.0 0.0 0.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 0.9 -0.9 0.3
Emphysema/chronic bronchitis 0.3 0.4 0.5 -0.7 0.5
Medication for pain relief, constipation, heartburn 0.2 0.3 0.5 0.1 0.7
Neck or shoulder pain in last month 0.1 0.1 0.2 0.4 0.0
Medication: Blood pressure 2.4 4.2 5.1 2.3 -1.8
Angina (self-reported) 1.2 1.6 2.4 0.9 -1.5
Migraine (self-reported) 0.3 0.4 0.6 -0.8 0.5
Medication: Ibuprofen 3.3 3.9 6.2 1.3 -2.5
Medication: Allopurinol 0.5 0.7 1.0 0.6 -1.0
Medication: Omeprazole 0.1 0.1 0.1 -0.2 0.3
Medication: Seretide 50 evohaler 0.4 0.5 0.6 0.6 -0.8
Mean time to correctly identify matches 0.2 0.4 0.7 0.8 -0.2
Heart disease (mother) 0.5 0.6 1.2 -0.1 -1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.7 5.6 10.1 3.2 -1.1
Whole body fat mass 2.0 8.4 10.8 -3.3 2.4
Leg fat mass (right) 1.8 7.0 9.2 -3.0 2.2
Arm predicted mass (right) 1.4 7.3 10.4 -3.2 2.1
Pulse rate, automated reading 0.2 0.6 1.0 -1.0 0.4
Alcohol intake frequency. 0.5 1.1 1.8 -1.4 0.7
Comparative height size at age 10 2.9 15.7 25.1 -5.0 2.5
Number of full sisters 0.7 0.8 0.9 -1.0 0.8
Suffer from ‘nerves’ 0.1 0.1 0.2 0.4 0.3
Overall health rating 0.2 0.5 0.7 -0.8 0.5
Chest pain or discomfort 0.5 0.7 1.4 0.3 -1.2
Had major operations 0.3 0.3 0.6 -0.8 0.0
Age at last live birth 4.6 6.7 7.3 2.5 -2.7
Family relationship satisfaction 0.5 0.6 0.8 0.6 -0.9
Leg pain on walking 0.2 0.3 0.4 0.7 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.1 -1.0 0.7
Commuting to job workplace: Car/motor vehicle 0.0 0.0 0.0 -0.2 0.2
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.4 0.2
Medication: Aspirin 1.3 1.7 2.7 0.8 -1.6
Supplements: Vitamin C 1.8 2.1 3.3 1.8 -0.9
Knee pain experienced in last month 0.1 0.1 0.2 -0.5 0.2
Hypertension (Self-reported) 0.1 0.3 0.4 0.4 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.1 -0.1 1.1
Illnesses of father: Heart disease 0.8 1.1 2.1 -0.1 -1.5
Illnesses of siblings: Diabetes 0.4 0.5 0.7 -0.5 0.8
Smoking status: Previous 5.1 7.7 11.0 2.1 -3.3
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 2.0 -1.3 1.4
Whole body fat-free mass 1.0 5.7 8.4 -2.9 1.7
Leg fat-free mass (right) 1.3 7.1 10.7 -3.3 1.9
Arm fat percentage (left) 0.5 2.0 2.2 -1.5 1.3
Average weekly red wine intake 2.7 4.0 7.7 2.8 -0.5
Handedness (chirality/laterality): Left-handed 2.5 3.0 5.4 2.3 -0.8
Mood swings 1.4 2.5 5.0 -0.2 -2.2
Loneliness, isolation 0.1 0.1 0.2 -0.5 -0.3
Long-standing illness, disability or infirmity 0.3 0.5 0.6 -0.6 -0.8
Ever had bowel cancer screening 2.4 2.8 4.9 2.2 -0.9
Diabetes diagnosed by doctor 1.4 2.2 4.1 2.0 0.6
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.0 1.0 -0.9
Friendships satisfaction 0.2 0.2 0.4 -0.6 0.0
Qualifications: nursing, teaching 1.0 1.6 2.5 0.8 -1.6
Commuting to job workplace: Walk 0.4 0.4 0.8 -0.9 -0.2
Eye problems/disorders: Cataract 0.2 0.3 0.4 0.4 -0.6
Mouth/teeth dental problems: Mouth ulcers 2.3 3.7 6.0 2.4 -1.2
Medication for cholesterol 1.1 1.6 2.8 -1.7 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 1.8 -0.9 1.4
Back pain experienced in last month 0.6 0.9 1.7 -0.4 1.3
Mineral and other dietary supplements 2.9 3.9 5.7 -2.4 1.5
Breast cancer (self-reported) 1.2 1.4 2.3 -1.5 0.7
Asthma (self-reported) 2.3 4.6 4.8 2.2 -2.1
Osteoporosis (self-reported) 0.0 0.0 0.0 -0.0 0.1
Osteoarthritis (self-reported) 0.0 0.0 0.0 0.1 0.1
Medication: Aspirin 1.7 2.3 3.2 1.1 -1.8
Medication: Gliclazide 1.0 1.2 2.1 0.5 1.4
Illnesses of father: None of the above (group 1) 0.5 0.7 0.8 0.9 0.7
Smoking status: Current 0.2 0.4 0.8 -0.9 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 0.8 0.1 0.9
Whole body water mass 1.1 6.5 9.2 -3.0 1.9
Leg predicted mass (right) 1.3 7.0 10.6 -3.3 1.8
Arm fat mass (left) 1.1 4.6 6.2 -2.5 1.7
Number of self-reported non-cancer illnesses 0.2 0.4 0.6 0.8 -0.3
Average weekly champagne plus white wine intake 1.0 1.3 2.2 1.5 -0.7
Miserableness 1.8 3.1 6.2 0.4 -2.5
Guilty feelings 0.3 0.5 0.7 -0.5 -0.8
Wears glasses or contact lenses 1.3 1.5 3.0 1.7 0.2
Ever taken oral contraceptive pill 0.9 1.0 1.7 1.3 -0.5
Hearing aid user 2.0 2.2 4.4 -0.1 -2.1
Mother’s age at death 2.8 3.6 4.9 1.5 -2.2
Financial situation satisfaction 0.1 0.2 0.2 -0.4 -0.4
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.2 -0.4
Commuting to job workplace: Public transport 1.3 1.5 1.8 1.1 -1.4
Eye problems/disorders: Glaucoma 0.9 1.1 2.2 -0.1 1.5
Medication: Blood pressure 1.1 2.0 2.2 1.4 -1.5
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.8 -0.1
Supplements: Fish oil (including cod liver oil) 1.0 1.3 2.1 1.4 -0.8
High cholesterol (Self-reported) 0.5 1.0 1.9 1.4 -0.2
Medication: Bendroflumethiazide 3.9 5.9 6.8 2.3 -2.6
Medication: Paracetamol 1.1 1.7 3.0 0.6 -1.7
Medication: Lisinopril 1.2 1.6 2.9 -0.5 1.7
Medication: Atorvastatin 3.5 4.3 5.4 2.3 -1.8
Illnesses of father: High blood pressure 0.2 0.3 0.4 -0.6 0.5
Alcohol drinker status: Never 0.1 0.2 0.3 -0.2 -0.5
Ever smoked 1.4 2.4 3.5 1.1 -1.9
Basal metabolic rate 1.3 7.0 10.3 -3.2 1.9
Leg fat percentage (left) 0.9 3.3 3.4 -1.9 1.8
Arm fat-free mass (left) 2.0 9.9 14.1 -3.8 2.4
Number of operations (self-reported) 0.0 0.0 0.0 0.1 0.0
Average weekly beer plus cider intake 0.0 0.0 0.0 0.2 0.1
Irritability 1.7 2.8 5.4 -0.5 -2.3
Risk taking 0.0 0.0 0.1 -0.3 0.1
Ever had prostate specific antigen (PSA) test 1.2 1.3 2.7 1.6 0.1
Fractured/broken bones in last 5 years 0.9 1.1 1.7 -0.8 1.3
Age started oral contraceptive pill 0.5 0.6 1.1 0.2 -1.1
Diastolic blood pressure, automated reading 0.2 0.6 1.1 -0.4 -1.0
Ever depressed for a whole week 0.4 0.5 0.9 1.0 0.4
Unable to work because of sickness or disability 0.1 0.1 0.2 0.3 -0.4
Commuting to job workplace: Cycle 1.0 1.2 2.3 0.4 -1.5
Myopia 4.6 6.6 8.1 2.9 -2.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.3 -0.6 0.4
Cholesterol lowering medication 1.3 1.9 3.9 2.0 0.1
Medication: Omeprazole (e.g. Zanprol) 0.1 0.1 0.2 0.1 0.5
Pain experienced in last month 0.2 0.4 0.7 -0.4 -0.8
Supplements: Calcium 0.0 0.0 0.0 0.2 -0.1
Basal cell carcinoma (self-reported) 0.1 0.1 0.2 0.2 0.5
Heart attack/myocardial infarction (self-reported) 1.8 2.3 2.8 1.3 -1.7
Deep venous thrombosis (DVT) (self-reported) 1.8 2.3 3.5 -1.9 1.1
Heart disease (siblings) 0.4 0.5 0.6 0.8 -0.7
Alcohol drinker status: Previous 0.0 0.0 0.0 0.1 -0.1
Pack years of smoking 0.2 0.3 0.3 -0.6 0.4
Impedance of whole body 0.0 0.0 0.1 0.0 0.2
Leg fat mass (left) 1.9 7.3 9.4 -3.1 2.3
Arm predicted mass (left) 1.8 9.4 13.4 -3.7 2.3