Best TWAS P=3.9e-09 · Best GWAS P=2.34e-09 conditioned to 2.18e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | RP4-761J14.8 | 0.11 | 0.02 | lasso | 2 | 0.00 | 1.7e-01 | -5.7 | -5.8 | 7.5e-09 | -0.09 | 0.02 | 0.89 | FALSE |
2 | GTEx | Brain Cerebellum | VAMP1 | 0.22 | 0.16 | enet | 27 | 0.20 | 1.5e-06 | 4.9 | 5.3 | 1.0e-07 | 0.02 | 0.04 | 0.94 | FALSE |
3 | GTEx | Skin Sun Exposed Lower leg | ZNF384 | 0.07 | 0.00 | enet | 14 | 0.00 | 2.2e-01 | 3.5 | -5.3 | 1.3e-07 | -0.11 | 0.05 | 0.22 | FALSE |
4 | METSIM | Adipose | ZNF384 | 0.08 | 0.02 | bslmm | 286 | 0.04 | 2.6e-07 | -4.3 | -5.9 | 3.9e-09 | 0.23 | 0.69 | 0.19 | TRUE |
5 | The Cancer Genome Atlas | Glioblastoma Multiforme | VAMP1 | 0.13 | 0.07 | blup | 78 | 0.10 | 5.6e-04 | 4.9 | 5.2 | 2.4e-07 | 0.06 | 0.01 | 0.91 | FALSE |
6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | VAMP1 | 0.09 | 0.12 | lasso | 3 | 0.10 | 5.5e-11 | 5.0 | 5.3 | 1.1e-07 | 0.00 | 0.06 | 0.93 | FALSE |
7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | VAMP1 | 0.21 | 0.30 | lasso | 6 | 0.32 | 1.6e-34 | 4.2 | 5.3 | 1.3e-07 | 0.02 | 0.08 | 0.91 | FALSE |
8 | The Cancer Genome Atlas | Stomach Adenocarcinoma | VAMP1 | 0.14 | 0.13 | blup | 77 | 0.15 | 8.9e-11 | 4.1 | 5.1 | 2.9e-07 | 0.02 | 0.24 | 0.74 | FALSE |