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chr12:11,585,380-15,743,444

Best TWAS P=1.53e-24 · Best GWAS P=1.35e-73 conditioned to 2.86e-83

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C12orf60	0.28	0.25	lasso	4	0.24	2.0e-29	9.2	9.7	4.1e-22	-0.04	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DUSP16	0.09	0.01	bslmm	553	0.02	6.7e-04	4.6	7.6	2.8e-14	0.04	0.45	0.02	TRUE
3	CommonMind	Brain Pre-frontal Cortex	LOH12CR1	0.17	0.12	enet	39	0.12	1.5e-14	3.7	5.8	5.4e-09	0.04	1.00	0.00	TRUE
4	CommonMind	Brain Pre-frontal Cortex	PLBD1	0.05	0.00	bslmm	365	0.01	4.9e-02	-2.1	5.3	1.2e-07	-0.01	0.04	0.06	FALSE
5	GTEx	Adipose Subcutaneous	KIAA1467	0.21	0.07	enet	17	0.06	1.5e-05	-6.9	-7.7	1.5e-14	0.04	0.98	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	WBP11	0.15	0.11	lasso	4	0.12	8.7e-07	-8.1	9.6	6.9e-22	-0.05	0.26	0.25	FALSE
7	GTEx	Artery Aorta	KIAA1467	0.31	0.03	enet	27	0.08	5.3e-05	-6.2	-7.2	4.5e-13	0.04	0.89	0.00	FALSE
8	GTEx	Artery Aorta	C12orf60	0.16	0.10	lasso	6	0.13	1.4e-07	5.7	6.5	9.4e-11	-0.01	0.94	0.00	FALSE
9	GTEx	Artery Tibial	KIAA1467	0.21	0.12	lasso	4	0.15	5.3e-12	-6.7	-7.4	1.9e-13	0.05	1.00	0.00	FALSE
10	GTEx	Artery Tibial	WBP11	0.09	0.06	lasso	2	0.06	3.8e-05	-8.4	9.1	1.2e-19	-0.06	0.93	0.00	FALSE
11	GTEx	Artery Tibial	HTR7P1	0.10	0.02	enet	15	0.03	1.6e-03	-4.0	-5.5	3.1e-08	0.02	0.33	0.03	FALSE
12	GTEx	Brain Caudate basal ganglia	C12orf60	0.39	0.34	lasso	3	0.32	5.4e-10	9.2	9.1	5.8e-20	-0.03	0.97	0.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	C12orf60	0.36	0.27	lasso	5	0.33	3.8e-09	9.2	7.9	2.8e-15	-0.02	0.88	0.01	FALSE
14	GTEx	Brain Cerebellum	C12orf60	0.19	0.17	lasso	3	0.13	1.2e-04	9.2	8.3	7.0e-17	-0.01	0.18	0.05	FALSE
15	GTEx	Brain Cortex	C12orf60	0.44	0.28	lasso	3	0.29	1.2e-08	9.1	9.7	3.2e-22	-0.02	0.79	0.02	FALSE
16	GTEx	Brain Cortex	RP11-695J4.2	0.41	0.04	lasso	14	0.09	1.7e-03	3.6	9.2	4.4e-20	-0.05	0.05	0.08	FALSE
17	GTEx	Brain Hypothalamus	C12orf60	0.28	0.27	lasso	4	0.19	3.8e-05	9.2	8.9	4.5e-19	-0.03	0.25	0.05	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	RP11-174G6.5	0.23	0.13	lasso	4	0.11	8.9e-04	-9.0	8.6	1.1e-17	-0.02	0.21	0.10	FALSE
19	GTEx	Brain Putamen basal ganglia	C12orf60	0.33	0.32	lasso	3	0.29	1.5e-07	9.2	9.3	1.5e-20	-0.02	0.41	0.04	FALSE
20	GTEx	Breast Mammary Tissue	MGP	0.24	-0.01	lasso	6	-0.01	8.1e-01	1.6	6.8	1.2e-11	-0.08	0.04	0.15	FALSE
21	GTEx	Breast Mammary Tissue	HTR7P1	0.19	0.10	lasso	3	0.12	1.2e-06	-6.6	-6.6	5.1e-11	0.02	0.31	0.04	FALSE
22	GTEx	Breast Mammary Tissue (Male)	KIAA1467	0.21	0.02	lasso	7	0.00	3.3e-01	-6.8	7.8	6.9e-15	-0.06	0.07	0.05	FALSE
23	GTEx	Breast Mammary Tissue (Female)	MGP	0.27	0.03	lasso	6	0.06	5.5e-03	5.2	5.2	1.6e-07	-0.05	0.06	0.07	FALSE
24	GTEx	Breast Mammary Tissue (Female)	C12orf60	0.19	0.17	lasso	3	0.12	2.6e-04	9.2	9.2	2.4e-20	-0.02	0.16	0.08	FALSE
25	GTEx	Cells Transformed fibroblasts	HEBP1	0.19	0.13	lasso	5	0.13	5.5e-10	-5.7	6.2	6.2e-10	-0.01	1.00	0.00	FALSE
26	GTEx	Cells Transformed fibroblasts	LRP6	0.27	0.15	enet	16	0.20	5.5e-15	4.4	6.2	5.2e-10	-0.03	1.00	0.00	TRUE
27	GTEx	Cells Transformed fibroblasts	KIAA1467	0.21	0.09	lasso	7	0.18	1.3e-13	-6.7	-8.1	4.1e-16	0.05	1.00	0.00	TRUE
28	GTEx	Cells Transformed fibroblasts	C12orf60	0.10	0.10	lasso	2	0.09	1.8e-07	9.3	9.6	5.4e-22	-0.03	1.00	0.00	FALSE
29	GTEx	Cells Transformed fibroblasts	HTR7P1	0.45	0.33	enet	29	0.40	2.2e-31	-6.6	5.6	2.2e-08	-0.02	1.00	0.00	FALSE
30	GTEx	Colon Sigmoid	HEBP1	0.19	0.07	enet	34	0.13	2.6e-05	-6.6	-6.6	3.9e-11	-0.01	0.36	0.08	FALSE
31	GTEx	Colon Transverse	HEBP1	0.35	0.31	lasso	6	0.32	1.2e-15	-6.2	-6.1	9.4e-10	0.01	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	HEBP1	0.26	0.16	enet	32	0.20	1.7e-12	-5.7	-6.4	1.3e-10	0.00	1.00	0.00	FALSE
33	GTEx	Heart Left Ventricle	KIAA1467	0.45	0.21	lasso	6	0.23	1.1e-12	-6.7	-7.1	1.3e-12	0.04	1.00	0.00	FALSE
34	GTEx	Heart Left Ventricle	C12orf60	0.24	0.23	lasso	5	0.26	7.1e-14	9.2	9.3	1.2e-20	-0.04	1.00	0.00	FALSE
35	GTEx	Heart Left Ventricle	H2AFJ	0.16	0.07	lasso	8	0.05	1.1e-03	-6.8	-6.7	2.4e-11	0.06	0.90	0.00	FALSE
36	GTEx	Liver	H2AFJ	0.18	0.11	lasso	8	0.04	2.7e-02	-6.8	-6.5	6.7e-11	0.05	0.15	0.05	FALSE
37	GTEx	Lung	KIAA1467	0.15	0.06	lasso	5	0.08	8.6e-07	-5.5	-7.8	6.1e-15	0.02	0.81	0.02	FALSE
38	GTEx	Muscle Skeletal	WBP11	0.08	0.08	lasso	5	0.08	2.4e-08	-8.1	8.6	7.3e-18	-0.07	0.98	0.00	FALSE
39	GTEx	Muscle Skeletal	C12orf60	0.23	0.10	lasso	4	0.12	1.1e-11	9.2	9.8	8.0e-23	-0.01	1.00	0.00	FALSE
40	GTEx	Nerve Tibial	KIAA1467	0.14	0.07	enet	14	0.06	2.3e-05	-6.8	-7.7	1.6e-14	0.04	1.00	0.00	FALSE
41	GTEx	Nerve Tibial	WBP11	0.11	0.10	lasso	3	0.09	1.0e-06	-8.4	7.7	1.7e-14	-0.07	0.96	0.00	FALSE
42	GTEx	Nerve Tibial	C12orf60	0.39	0.27	enet	11	0.30	9.6e-22	9.2	9.4	4.3e-21	-0.03	1.00	0.00	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	C12orf60	0.15	0.16	lasso	2	0.13	1.6e-07	9.1	9.5	1.8e-21	-0.03	0.98	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	KIAA1467	0.18	0.10	lasso	4	0.08	4.4e-07	-6.8	5.7	1.0e-08	-0.04	1.00	0.00	FALSE
45	GTEx	Skin Sun Exposed Lower leg	C12orf60	0.09	0.06	enet	11	0.05	4.0e-05	9.2	10.0	2.2e-23	-0.06	0.94	0.00	FALSE
46	GTEx	Stomach	KIAA1467	0.30	0.12	lasso	11	0.12	2.8e-06	-6.8	-8.0	1.0e-15	0.04	0.95	0.00	FALSE
47	GTEx	Testis	KIAA1467	0.25	0.11	lasso	9	0.08	2.4e-04	-6.8	-6.9	6.7e-12	0.04	0.84	0.02	FALSE
48	GTEx	Thyroid	KIAA1467	0.15	0.03	enet	17	0.08	8.4e-07	-6.1	-7.7	1.5e-14	0.05	0.99	0.00	FALSE
49	GTEx	Thyroid	C12orf60	0.16	0.10	enet	9	0.12	8.1e-10	9.3	9.4	7.6e-21	-0.02	1.00	0.00	FALSE
50	GTEx	Thyroid	HTR7P1	0.14	0.14	enet	9	0.15	8.4e-12	-6.6	6.3	3.2e-10	-0.02	1.00	0.00	FALSE
51	METSIM	Adipose	C12orf60	0.14	0.10	lasso	4	0.08	1.2e-12	9.2	9.2	4.0e-20	-0.03	1.00	0.00	FALSE
52	METSIM	Adipose	HEBP1	0.05	0.03	lasso	13	0.03	9.2e-05	-6.5	6.6	3.2e-11	-0.02	0.99	0.00	FALSE
53	METSIM	Adipose	MGP	0.04	0.04	bslmm	359	0.04	6.2e-07	-4.5	7.2	5.9e-13	-0.01	1.00	0.00	FALSE
54	NTR	Blood	HEBP1	0.13	0.17	lasso	3	0.16	5.6e-51	-5.7	5.9	4.1e-09	0.00	1.00	0.00	FALSE
55	NTR	Blood	LOH12CR1	0.06	0.02	bslmm	590	0.02	1.4e-07	5.3	7.0	2.6e-12	0.02	1.00	0.00	FALSE
56	NTR	Blood	PLBD1	0.09	0.08	enet	22	0.11	1.8e-33	-9.6	8.9	4.5e-19	-0.04	0.25	0.75	TRUE
57	ROSMAP	Brain Pre-frontal Cortex	HEBP1	0.10	0.09	lasso	3	0.09	2.2e-11	-6.5	-6.5	8.9e-11	0.02	1.00	0.00	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	WBP11	0.10	0.05	lasso	4	0.06	1.2e-08	-8.4	9.5	2.2e-21	-0.09	1.00	0.00	FALSE
59	ROSMAP	Brain Pre-frontal Cortex	C12orf60	0.26	0.29	lasso	5	0.29	1.9e-37	9.1	9.1	1.0e-19	-0.02	1.00	0.00	FALSE
60	YFS	Blood	CDKN1B	0.03	0.03	enet	15	0.03	2.1e-10	-9.9	7.2	6.3e-13	0.03	1.00	0.00	TRUE
61	YFS	Blood	H2AFJ	0.05	0.02	bslmm	360	0.03	2.9e-10	-6.8	-8.7	2.4e-18	0.06	1.00	0.00	FALSE
62	YFS	Blood	HEBP1	0.34	0.49	enet	48	0.49	9.8e-188	-5.7	6.3	3.2e-10	-0.01	1.00	0.00	FALSE
63	YFS	Blood	KIAA1467	0.04	0.01	enet	21	0.03	1.7e-09	-6.3	-6.8	9.8e-12	0.04	0.98	0.00	FALSE
64	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C12orf60	0.17	0.03	blup	56	0.07	2.9e-06	9.3	8.4	3.0e-17	-0.06	0.00	0.99	FALSE
65	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HTR7P1	0.10	0.03	blup	62	0.05	3.2e-05	-6.6	5.7	1.4e-08	-0.03	0.07	0.87	FALSE
66	The Cancer Genome Atlas	Breast Invasive Carcinoma	C12orf60	0.05	0.04	enet	4	0.04	7.3e-09	9.1	8.6	7.3e-18	-0.02	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Breast Invasive Carcinoma	HEBP1	0.03	0.02	lasso	3	0.01	1.8e-03	-6.8	7.1	1.0e-12	-0.05	0.00	0.99	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	HTR7P1	0.07	0.03	blup	62	0.06	2.8e-12	-6.6	7.7	1.0e-14	-0.02	0.06	0.94	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	KIAA1467	0.02	0.01	blup	51	0.01	2.3e-02	-6.9	5.2	1.6e-07	-0.06	0.01	0.97	FALSE
70	The Cancer Genome Atlas	Colon Adenocarcinoma	HEBP1	0.19	0.21	blup	67	0.22	1.1e-12	-6.1	-6.7	2.1e-11	0.01	0.14	0.86	FALSE
71	The Cancer Genome Atlas	Glioblastoma Multiforme	C12orf60	0.24	0.09	enet	11	0.13	1.2e-04	9.1	8.3	9.1e-17	-0.05	0.01	0.82	FALSE
72	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf60	0.10	0.04	enet	7	0.05	2.0e-06	-7.5	8.0	1.3e-15	-0.04	0.02	0.96	FALSE
73	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf60	0.07	0.08	lasso	3	0.07	1.1e-08	9.1	8.9	8.0e-19	-0.02	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	GPR19	0.07	0.04	enet	14	0.04	4.1e-05	-5.8	-5.6	2.5e-08	0.02	0.10	0.58	FALSE
75	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C12orf60	0.12	0.07	enet	8	0.07	5.4e-05	9.1	9.8	1.3e-22	-0.06	0.01	0.97	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf60	0.14	0.14	lasso	4	0.13	2.2e-14	9.1	9.4	4.7e-21	-0.03	0.01	0.99	FALSE
77	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP11	0.03	0.03	blup	57	0.02	2.3e-03	-6.8	7.2	6.8e-13	-0.07	0.12	0.16	FALSE
78	The Cancer Genome Atlas	Lung Adenocarcinoma	C12orf60	0.07	0.05	enet	7	0.05	1.5e-06	9.1	9.1	5.9e-20	-0.05	0.01	0.99	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	GPR19	0.06	0.00	blup	65	0.01	8.6e-03	-12.2	-6.4	1.9e-10	0.04	0.00	0.97	TRUE
80	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C12orf60	0.05	0.05	lasso	3	0.04	1.1e-05	9.1	9.3	1.7e-20	-0.04	0.01	0.99	FALSE
81	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HTR7P1	0.03	0.04	lasso	1	0.03	1.4e-04	-6.5	6.5	5.8e-11	-0.02	0.07	0.88	FALSE
82	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1467	0.03	0.01	blup	51	0.01	7.6e-03	-2.5	5.6	2.2e-08	-0.07	0.01	0.83	FALSE
83	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C12orf60	0.10	0.01	blup	56	0.07	1.6e-05	9.3	7.4	1.1e-13	-0.04	0.01	0.90	FALSE
84	The Cancer Genome Atlas	Prostate Adenocarcinoma	C12orf60	0.05	0.03	lasso	1	0.01	1.2e-02	9.2	9.2	4.7e-20	-0.02	0.01	0.92	FALSE
85	The Cancer Genome Atlas	Prostate Adenocarcinoma	KIAA1467	0.03	0.02	blup	49	0.01	3.9e-02	-6.6	-7.3	3.9e-13	0.03	0.03	0.34	FALSE
86	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HEBP1	0.17	0.08	blup	68	0.09	3.6e-04	-5.9	-7.2	7.7e-13	0.03	0.08	0.53	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf60	0.16	0.16	enet	10	0.18	1.3e-17	9.1	10.2	1.5e-24	-0.05	0.01	0.99	TRUE
88	The Cancer Genome Atlas	Thyroid Carcinoma	HTR7P1	0.16	0.04	enet	5	0.09	1.1e-08	-3.7	5.6	1.8e-08	0.01	0.38	0.62	FALSE