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chr12:191,619-4,681,330

Best TWAS P=1.76e-64 · Best GWAS P=9.61e-57 conditioned to 0.196

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TULP3	0.17	0.18	enet	13	0.17	2.5e-20	5.8	-6.1	9.8e-10	0.04	1.00	0.00	FALSE
2	GTEx	Adrenal Gland	TULP3	0.22	0.20	lasso	3	0.19	2.4e-07	5.9	6.4	1.6e-10	-0.03	0.78	0.02	TRUE
3	GTEx	Artery Aorta	B4GALNT3	0.36	0.17	enet	27	0.25	6.3e-14	14.9	-12.4	4.5e-35	-0.74	0.08	0.92	FALSE
4	GTEx	Artery Tibial	TSPAN9	0.12	0.00	enet	25	0.04	2.9e-04	4.1	5.6	2.2e-08	-0.07	0.12	0.07	TRUE
5	GTEx	Artery Tibial	B4GALNT3	0.49	0.24	enet	24	0.34	6.5e-28	15.9	-17.0	1.8e-64	-0.91	0.00	1.00	TRUE
6	GTEx	Brain Nucleus accumbens basal ganglia	KDM5A	0.24	0.01	lasso	3	0.01	1.8e-01	8.0	12.0	4.3e-33	0.28	0.08	0.05	TRUE
7	GTEx	Brain Putamen basal ganglia	NRIP2	0.48	0.07	enet	22	0.21	8.8e-06	5.0	-5.3	1.4e-07	0.08	0.23	0.05	FALSE
8	GTEx	Brain Putamen basal ganglia	CCDC77	0.25	0.00	enet	13	0.06	1.8e-02	-1.4	6.2	7.2e-10	0.09	0.10	0.06	FALSE
9	GTEx	Breast Mammary Tissue	CCDC77	0.10	0.01	enet	12	0.02	2.1e-02	-2.7	5.8	5.6e-09	0.14	0.08	0.04	FALSE
10	GTEx	Breast Mammary Tissue	RHNO1	0.13	0.10	lasso	3	0.09	3.6e-05	5.8	-6.1	1.1e-09	0.05	0.98	0.00	FALSE
11	GTEx	Breast Mammary Tissue (Female)	CCDC77	0.16	0.01	lasso	2	0.00	2.4e-01	-5.5	7.2	6.8e-13	0.16	0.05	0.05	TRUE
12	GTEx	Cells Transformed fibroblasts	TULP3	0.19	0.08	enet	22	0.11	1.4e-08	5.9	-5.6	2.5e-08	0.05	0.99	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	RHNO1	0.32	0.20	lasso	7	0.19	4.6e-14	5.0	-5.3	1.5e-07	0.09	1.00	0.00	FALSE
14	GTEx	Esophagus Mucosa	RHNO1	0.33	0.26	enet	12	0.26	3.7e-17	5.0	-5.5	5.0e-08	0.09	1.00	0.00	FALSE
15	GTEx	Esophagus Muscularis	TULP3	0.13	0.05	lasso	4	0.05	5.4e-04	5.6	6.3	2.6e-10	-0.05	0.91	0.00	FALSE
16	GTEx	Heart Atrial Appendage	CCDC77	0.15	0.10	lasso	2	0.11	8.8e-06	-5.4	5.7	1.2e-08	0.17	0.67	0.03	FALSE
17	GTEx	Nerve Tibial	TULP3	0.13	0.05	lasso	2	0.06	6.0e-05	5.9	-5.9	2.8e-09	0.04	0.94	0.01	FALSE
18	GTEx	Nerve Tibial	RHNO1	0.20	0.07	enet	37	0.10	1.4e-07	5.2	-6.1	1.4e-09	0.05	1.00	0.00	FALSE
19	GTEx	Nerve Tibial	RP11-253E3.3	0.13	0.00	lasso	3	0.00	5.3e-01	5.8	-5.6	2.3e-08	0.06	0.08	0.07	FALSE
20	GTEx	Pituitary	PARP11	0.45	0.16	lasso	11	0.19	1.3e-05	-4.1	6.7	1.7e-11	-0.02	0.20	0.06	TRUE
21	GTEx	Prostate	NINJ2	0.48	0.00	enet	25	0.01	1.6e-01	1.2	7.1	1.2e-12	0.18	0.04	0.16	TRUE
22	GTEx	Skin Not Sun Exposed Suprapubic	CCDC77	0.12	0.07	enet	17	0.10	2.8e-06	-4.1	5.9	4.6e-09	0.14	0.85	0.01	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	RHNO1	0.21	0.04	enet	53	0.06	4.9e-04	5.9	-6.2	4.2e-10	0.03	0.60	0.02	FALSE
24	GTEx	Skin Sun Exposed Lower leg	TULP3	0.36	0.35	lasso	7	0.35	3.5e-30	5.9	-5.9	4.6e-09	0.04	1.00	0.00	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RHNO1	0.22	0.14	enet	18	0.16	1.4e-13	5.0	-6.0	1.5e-09	0.09	1.00	0.00	FALSE
26	GTEx	Testis	PARP11	0.25	0.11	lasso	6	0.13	2.5e-06	-5.3	5.7	9.5e-09	0.01	0.93	0.00	FALSE
27	METSIM	Adipose	ERC1	0.08	0.05	enet	25	0.04	9.3e-07	-3.1	-6.6	4.8e-11	-0.04	0.97	0.00	FALSE
28	METSIM	Adipose	SLC6A12	0.07	0.01	bslmm	323	0.02	4.5e-04	-14.4	6.6	3.5e-11	0.29	0.51	0.09	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	TULP3	0.32	0.38	lasso	6	0.40	5.0e-56	5.9	-5.3	9.0e-08	0.04	1.00	0.00	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	PARP11	0.25	0.21	enet	26	0.28	2.8e-36	-4.8	5.3	1.2e-07	0.02	1.00	0.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	B4GALNT3	0.05	0.04	lasso	3	0.03	7.4e-05	-6.7	-8.2	2.8e-16	-0.17	0.44	0.18	FALSE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TULP3	0.04	0.02	blup	70	0.02	6.2e-03	3.8	-5.4	7.8e-08	0.07	0.25	0.04	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC6A12	0.03	0.02	enet	8	0.02	1.1e-04	7.0	-6.3	3.1e-10	0.05	0.76	0.01	FALSE
34	The Cancer Genome Atlas	Esophageal Carcinoma	RAD52	0.25	0.13	blup	66	0.19	1.1e-06	4.6	-6.1	1.0e-09	-0.01	0.01	0.97	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C12orf32	0.04	0.03	enet	10	0.05	5.4e-06	5.0	-5.2	1.7e-07	0.07	0.55	0.02	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	B4GALNT3	0.07	0.02	blup	119	0.06	3.4e-07	12.0	9.4	5.3e-21	0.57	0.00	0.98	FALSE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C12orf32	0.05	0.06	blup	47	0.05	4.2e-06	5.2	-6.0	2.1e-09	0.08	0.98	0.01	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERC1	0.10	0.02	blup	219	0.06	7.6e-07	-3.2	-8.8	1.4e-18	0.02	0.30	0.03	TRUE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TULP3	0.03	0.01	blup	70	0.01	3.8e-02	5.9	6.4	1.7e-10	-0.04	0.03	0.04	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	C12orf32	0.02	0.03	lasso	3	0.02	6.9e-04	5.2	-5.3	1.5e-07	0.08	0.08	0.04	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	TULP3	0.08	0.11	lasso	5	0.10	1.0e-11	5.9	-5.8	7.5e-09	0.04	0.92	0.08	FALSE
42	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC6A12	0.06	0.02	blup	58	0.04	5.1e-05	-4.8	-6.5	1.1e-10	-0.04	0.45	0.05	TRUE
43	The Cancer Genome Atlas	Stomach Adenocarcinoma	C12orf32	0.03	0.00	blup	47	0.02	2.6e-02	4.3	-5.4	8.4e-08	0.06	0.06	0.04	FALSE
44	The Cancer Genome Atlas	Stomach Adenocarcinoma	ERC1	0.12	0.00	blup	218	0.05	8.9e-05	-1.9	-6.9	7.1e-12	0.02	0.03	0.08	FALSE
45	The Cancer Genome Atlas	Thyroid Carcinoma	C12orf32	0.04	0.02	enet	4	0.03	2.5e-04	3.9	-6.0	2.1e-09	0.05	0.21	0.06	FALSE