Best TWAS P=1.94e-12 · Best GWAS P=2.2e-21 conditioned to 1.36e-05
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | PRR13 | 0.23 | 0.28 | enet | 39 | 0.30 | 4.3e-17 | 2.4 | -5.3 | 9.5e-08 | -0.02 | 1.00 | 0.00 | FALSE |
2 | GTEx | Artery Coronary | SP1 | 0.17 | 0.12 | lasso | 4 | 0.12 | 8.6e-05 | 4.8 | 7.0 | 3.4e-12 | 0.23 | 0.20 | 0.51 | FALSE |
3 | GTEx | Brain Hippocampus | AAAS | 0.32 | 0.04 | enet | 23 | 0.04 | 4.6e-02 | -4.3 | -7.0 | 3.3e-12 | -0.08 | 0.08 | 0.08 | TRUE |
4 | GTEx | Breast Mammary Tissue | SP1 | 0.12 | 0.13 | lasso | 5 | 0.08 | 9.5e-05 | 4.0 | 6.1 | 8.3e-10 | 0.17 | 0.77 | 0.18 | TRUE |
5 | GTEx | Heart Left Ventricle | RP11-793H13.11 | 0.12 | 0.00 | enet | 17 | 0.05 | 1.6e-03 | -4.2 | 5.6 | 1.8e-08 | 0.05 | 0.25 | 0.12 | TRUE |
6 | GTEx | Thyroid | PRR13 | 0.22 | 0.18 | lasso | 9 | 0.24 | 4.8e-18 | 4.7 | -5.1 | 2.9e-07 | 0.00 | 1.00 | 0.00 | FALSE |
7 | METSIM | Adipose | SOAT2 | 0.03 | 0.06 | lasso | 1 | 0.05 | 1.5e-08 | 5.7 | -5.7 | 1.3e-08 | -0.36 | 1.00 | 0.00 | FALSE |
8 | METSIM | Adipose | SP7 | 0.03 | 0.02 | lasso | 2 | 0.01 | 6.1e-03 | 5.7 | -7.0 | 1.9e-12 | -0.47 | 0.23 | 0.09 | TRUE |
9 | METSIM | Adipose | SPRYD3 | 0.15 | 0.06 | lasso | 10 | 0.05 | 8.8e-08 | 4.7 | 6.5 | 9.7e-11 | 0.69 | 0.03 | 0.97 | FALSE |
10 | YFS | Blood | SP1 | 0.22 | 0.17 | bslmm | 398 | 0.18 | 1.4e-56 | 4.9 | 5.3 | 1.1e-07 | 0.06 | 1.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PRR13 | 0.13 | 0.04 | blup | 28 | 0.07 | 3.3e-06 | 4.8 | -6.1 | 8.3e-10 | -0.03 | 0.08 | 0.34 | FALSE |
12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PRR13 | 0.03 | 0.03 | blup | 28 | 0.04 | 4.6e-05 | 4.7 | -5.4 | 6.6e-08 | 0.01 | 0.44 | 0.09 | FALSE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PRR13 | 0.08 | 0.05 | blup | 28 | 0.07 | 6.3e-08 | 4.6 | -5.5 | 3.0e-08 | -0.01 | 0.96 | 0.03 | FALSE |
14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PRR13 | 0.07 | 0.04 | blup | 28 | 0.05 | 4.7e-06 | 2.4 | -5.7 | 1.2e-08 | -0.04 | 0.48 | 0.06 | FALSE |