Best TWAS P=1.38e-105 · Best GWAS P=6.69e-171 conditioned to 2.07e-70
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | MRPL42 | 0.21 | -0.01 | lasso | 2 | -0.01 | 6.0e-01 | 17.7 | -17.3 | 4.1e-67 | -0.47 | 0.05 | 0.05 | TRUE |
| 2 | GTEx | Muscle Skeletal | MRPL42 | 0.07 | 0.02 | lasso | 3 | 0.04 | 1.5e-04 | -9.2 | -8.4 | 5.6e-17 | -0.16 | 0.70 | 0.01 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | UBE2N | 0.09 | 0.07 | lasso | 2 | 0.06 | 1.6e-05 | 10.3 | 9.4 | 3.7e-21 | 0.16 | 0.91 | 0.00 | FALSE |
| 4 | GTEx | Small Intestine Terminal Ileum | MRPL42 | 0.49 | -0.01 | enet | 25 | 0.00 | 3.8e-01 | -2.5 | -5.4 | 5.6e-08 | -0.11 | 0.06 | 0.06 | TRUE |
| 5 | GTEx | Testis | MRPL42 | 0.35 | 0.17 | lasso | 3 | 0.24 | 3.3e-11 | -8.1 | -9.6 | 7.2e-22 | -0.14 | 1.00 | 0.00 | FALSE |
| 6 | NTR | Blood | SOCS2 | 0.04 | 0.02 | bslmm | 454 | 0.02 | 6.5e-08 | 19.4 | 13.9 | 4.5e-44 | -0.20 | 1.00 | 0.00 | TRUE |
| 7 | YFS | Blood | MRPL42 | 0.06 | 0.03 | lasso | 6 | 0.04 | 1.7e-14 | -8.2 | -6.7 | 2.0e-11 | -0.13 | 1.00 | 0.00 | FALSE |
| 8 | YFS | Blood | SOCS2 | 0.06 | 0.04 | bslmm | 444 | 0.04 | 1.7e-12 | 19.4 | 21.8 | 1.4e-105 | 0.08 | 1.00 | 0.00 | TRUE |
| 9 | YFS | Blood | UBE2N | 0.02 | 0.00 | bslmm | 424 | 0.01 | 3.6e-03 | 24.3 | 9.6 | 1.0e-21 | 0.38 | 0.06 | 0.32 | TRUE |
| 10 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | MRPL42 | 0.17 | 0.06 | enet | 6 | 0.05 | 3.5e-05 | -8.4 | 5.6 | 2.2e-08 | 0.03 | 0.18 | 0.49 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MRPL42 | 0.05 | 0.03 | blup | 49 | 0.04 | 3.9e-08 | -8.1 | 8.0 | 1.2e-15 | 0.09 | 0.67 | 0.29 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MRPL42 | 0.09 | 0.04 | enet | 10 | 0.06 | 5.9e-07 | -3.6 | 5.5 | 4.4e-08 | 0.05 | 0.24 | 0.04 | FALSE |
| 13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MRPL42 | 0.05 | 0.02 | blup | 49 | 0.03 | 5.1e-04 | 8.5 | 10.1 | 4.0e-24 | 0.15 | 0.06 | 0.18 | FALSE |
| 14 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MRPL42 | 0.11 | 0.06 | lasso | 2 | 0.09 | 7.1e-07 | -8.4 | 9.7 | 3.1e-22 | 0.15 | 0.02 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MRPL42 | 0.07 | 0.03 | blup | 49 | 0.03 | 1.4e-04 | -8.2 | 12.0 | 3.0e-33 | 0.21 | 0.25 | 0.66 | FALSE |
| 16 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MRPL42 | 0.12 | 0.01 | blup | 49 | 0.04 | 4.0e-04 | -8.2 | 10.3 | 1.1e-24 | 0.18 | 0.02 | 0.08 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | MRPL42 | 0.09 | 0.00 | enet | 8 | 0.03 | 9.4e-04 | -8.1 | 6.5 | 1.0e-10 | 0.02 | 0.04 | 0.04 | FALSE |