Best TWAS P=3.69e-16 · Best GWAS P=2.68e-22 conditioned to 5.33e-06
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PPP2R5A | 0.09 | 0.05 | enet | 11 | 0.06 | 1.9e-07 | 8.0 | 7.7 | 1.2e-14 | 0.55 | 1.00 | 0.00 | FALSE |
2 | GTEx | Brain Cerebellum | RP11-318L16.6 | 0.21 | 0.15 | lasso | 1 | 0.08 | 2.9e-03 | 8.1 | -8.2 | 3.7e-16 | 0.05 | 0.00 | 0.97 | TRUE |
3 | GTEx | Esophagus Mucosa | TMEM206 | 0.28 | 0.27 | lasso | 10 | 0.27 | 3.2e-18 | -7.0 | 7.8 | 7.6e-15 | 0.67 | 1.00 | 0.00 | TRUE |
4 | GTEx | Skin Sun Exposed Lower leg | NENF | 0.11 | 0.08 | lasso | 4 | 0.07 | 1.7e-06 | -6.4 | 6.1 | 9.5e-10 | 0.55 | 0.96 | 0.01 | FALSE |
5 | GTEx | Testis | TMEM206 | 0.13 | 0.04 | lasso | 7 | 0.03 | 1.2e-02 | -4.8 | 6.2 | 6.9e-10 | 0.59 | 0.13 | 0.37 | FALSE |
6 | METSIM | Adipose | PPP2R5A | 0.05 | 0.02 | blup | 456 | 0.03 | 1.8e-05 | 9.7 | -5.8 | 6.1e-09 | -0.65 | 0.00 | 1.00 | TRUE |
7 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TMEM206 | 0.06 | 0.06 | blup | 64 | 0.06 | 1.8e-05 | -7.0 | 6.0 | 2.1e-09 | 0.46 | 0.52 | 0.24 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMEM206 | 0.14 | 0.01 | lasso | 5 | 0.03 | 7.5e-03 | -7.0 | 6.2 | 7.5e-10 | 0.45 | 0.10 | 0.36 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM206 | 0.07 | 0.05 | blup | 64 | 0.06 | 8.0e-07 | -7.0 | 5.8 | 6.1e-09 | 0.39 | 0.73 | 0.23 | FALSE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM206 | 0.09 | 0.02 | lasso | 4 | 0.06 | 2.8e-07 | -6.9 | -6.6 | 4.2e-11 | -0.57 | 0.88 | 0.10 | FALSE |
11 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | INTS7 | 0.07 | 0.00 | blup | 70 | 0.00 | 1.9e-01 | 3.5 | 7.8 | 9.1e-15 | -0.09 | 0.02 | 0.59 | TRUE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | TMEM206 | 0.05 | 0.04 | lasso | 4 | 0.04 | 4.7e-05 | -7.0 | 6.8 | 1.5e-11 | 0.56 | 0.26 | 0.12 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PPP2R5A | 0.05 | 0.03 | lasso | 2 | 0.04 | 2.5e-05 | -2.6 | -7.4 | 1.8e-13 | -0.83 | 0.00 | 0.97 | FALSE |
14 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TMEM206 | 0.25 | 0.07 | enet | 12 | 0.18 | 5.7e-07 | -7.0 | 6.2 | 7.9e-10 | 0.47 | 0.35 | 0.22 | FALSE |