TWAS hub - INTS7

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Thyroid	0.224	0.060	8.2e-05	0.104	NA	0.058	NA	0.075	2.5e-08	NA	3.1e-05	NA	2.4e-06
2	TCGA	Liver Hepatocellular Carcinoma	0.072	0.038	4.1e-03	0.005	0.005	0.002	NA	0.003	1.9e-01	0.19	2.5e-01	NA	2.1e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Eye problems/disorders: Cataract	5.0	5.8	8.4	2.9	1.8
Hand grip strength (left)	3.8	10.1	20.0	-0.5	4.5
Reason for reducing amount of alcohol drunk: Health precaution	3.5	4.1	4.2	-2.0	-2.1
Trunk fat-free mass	3.4	19.7	37.2	-1.5	6.1
Illnesses of mother	3.4	4.2	5.3	2.3	1.7
Trunk predicted mass	3.4	19.6	37.0	-1.5	6.1
Whole body water mass	3.4	19.5	36.0	-1.8	6.0
Hand grip strength (right)	3.3	8.9	17.6	-0.4	4.2
Prospective memory result	3.3	4.1	6.4	-1.4	-2.5
Whole body fat-free mass	3.3	19.1	35.6	-1.6	6.0
Had menopause	3.2	4.0	6.4	-1.3	-2.5
Leg fat-free mass (right)	3.2	17.0	31.4	-1.6	5.6
Leg predicted mass (right)	3.2	17.1	31.6	-1.6	5.6
Arm fat-free mass (right)	3.1	15.8	26.0	-2.4	5.1
Arm predicted mass (right)	3.1	16.1	28.3	-2.0	5.3
Leg fat-free mass (left)	3.0	16.0	29.9	-1.4	5.5
Leg predicted mass (left)	3.0	16.1	29.7	-1.6	5.5
Mouth/teeth dental problems: Bleeding gums	3.0	3.8	4.8	-1.7	-2.2
Basal metabolic rate	3.0	16.8	30.6	-1.7	5.5
Arm predicted mass (left)	2.9	14.7	25.6	-1.9	5.1
Arm fat-free mass (left)	2.8	14.3	24.6	-2.0	5.0
Ever had stillbirth, spontaneous miscarriage or termination	2.7	2.9	5.2	-2.3	-0.7
Smoking Status	2.4	5.7	6.6	-2.2	-2.6
Medication: Levothyroxine sodium	2.3	3.9	6.2	2.5	1.2
Medication: Co-codamol	2.2	2.6	5.2	-2.3	-0.0
Comparative height size at age 10	2.2	12.1	24.1	-0.4	4.9
Ever had hysterectomy (womb removed)	2.1	2.4	2.7	1.6	1.4
Standing height	2.1	21.1	42.1	-0.2	6.5
Pulse wave peak to peak time	2.1	2.4	4.9	-0.0	2.2
Breast cancer (self-reported)	2.1	2.5	5.0	0.2	2.2
Basal cell carcinoma (self-reported)	2.1	2.5	2.9	-1.5	-1.7
Stomach or abdominal pain in last month	2.0	2.5	3.1	1.4	1.8
Illnesses of father: Heart disease	2.0	2.8	5.6	-0.2	-2.4
Osteoarthritis (self-reported)	2.0	2.6	5.0	2.2	0.4
Ever depressed for a whole week	2.0	2.5	4.8	0.4	-2.2
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	2.9	1.7	1.4
Pack years adult smoking proportion	1.9	3.0	4.1	2.0	-1.3
Shortness of breath walking on level ground	1.9	2.3	3.0	1.7	1.3
Long-standing illness, disability or infirmity	1.9	2.9	4.5	2.1	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.3	4.6	-2.1	-0.1
Pack years of smoking	1.9	2.9	3.2	1.8	-1.6
Other serious medical condition/disability diagnosed by doctor	1.8	2.4	4.1	2.0	0.8
Medication: Paracetamol	1.8	2.9	4.5	-1.1	2.1
Neuroticism (2016)	1.7	2.5	4.0	-2.0	-0.9
Bilateral oophorectomy (both ovaries removed)	1.7	1.9	3.3	0.7	1.8
Pain all over the body in last month	1.7	1.8	2.6	-1.6	-1.0
Exposure to tobacco smoke at home	1.7	1.9	3.8	1.9	0.1
Birth weight	1.7	3.8	7.5	-2.7	-0.3
Eye problems/disorders: None of the above	1.7	2.0	2.2	-1.3	-1.5
Mean time to correctly identify matches	1.7	3.2	4.8	1.3	-2.2
Medication: Gliclazide	1.7	1.9	2.7	1.6	1.0
Tinnitus: Yes, now most or all of the time	1.7	2.0	3.2	-0.9	1.8
Risk taking	1.7	2.5	2.8	-1.7	-1.5
Ulcerative Colitis	1.6	2.3	4.7	-2.2	-0.1
Height	1.6	30.4	60.1	0.8	7.8
Hypothyroidism (self reported)	1.6	3.6	7.0	2.6	0.4
Hypothyroidism/myxoedema (self-reported)	1.6	3.1	5.9	2.4	0.5
Medication: Lisinopril	1.6	2.1	4.2	2.0	0.3
Age started oral contraceptive pill	1.6	2.0	3.9	0.0	-2.0
Chronotype (morning person)	1.5	3.4	6.7	-0.4	2.6
Medication: Ramipril	1.5	1.9	2.1	-1.3	-1.4
Weight	1.5	7.4	11.6	-1.8	3.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.7	-0.2	1.9
Pulse wave Arterial Stiffness index	1.5	1.7	3.4	-0.0	-1.9
Headache pain in last month	1.5	2.5	3.3	-1.3	1.8
Medication for pain relief, constipation, heartburn	1.5	2.6	3.5	1.3	-1.9
Number of full sisters	1.5	1.9	3.1	-1.8	-0.8
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	3.4	-1.9	-0.5
Medication: Atorvastatin	1.5	1.8	2.0	1.4	1.3
Impedance of whole body	1.5	7.5	10.7	2.1	-3.3
Blood Platelet Count	1.4	16.0	24.9	5.0	2.7
Impedance of leg (right)	1.4	6.7	11.3	1.4	-3.4
Sitting height	1.4	9.7	19.3	-0.4	4.4
Impedance of arm (right)	1.4	6.5	6.9	2.5	-2.6
Medication: Ventolin 100micrograms inhaler	1.4	1.8	2.3	-1.5	1.1
Forced vital capacity (FVC), Best measure	1.4	4.9	9.4	-0.7	3.1
Medication: Ibuprofen	1.4	1.6	3.0	-0.6	1.7
Medication: Omeprazole	1.4	1.7	2.8	1.7	0.8
Pain type(s) experienced in last month: Hip pain	1.4	1.7	3.3	1.8	0.4
Age at First Birth	1.3	2.0	3.0	1.0	1.7
Severe depression (siblings)	1.3	1.4	2.4	1.6	0.6
Townsend deprivation index at recruitment	1.3	1.8	3.4	-0.4	-1.9
Impedance of leg (left)	1.3	6.4	11.6	1.1	-3.4
Impedance of arm (left)	1.3	5.8	6.2	2.3	-2.5
Migraine (self-reported)	1.3	1.6	3.1	-0.2	1.8
Friendships satisfaction	1.3	1.6	2.7	0.7	1.6
Alzheimer’s Disease (in mother)	1.2	1.4	1.9	-1.0	-1.4
Systolic Blood Pressure	1.2	6.0	10.5	-3.2	-1.2
Hearing difficulty/problems: Yes	1.2	1.8	2.9	1.7	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.9	7.7	-0.1	2.8
Peak expiratory flow (PEF)	1.2	2.8	5.7	-0.0	2.4
Suffer from ‘nerves’	1.2	1.9	3.4	0.6	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	5.0	-0.1	2.2
Commuting to job workplace: Walk	1.2	1.3	1.5	-1.2	-1.0
Schizophrenia vs Biploar Disorder	1.1	1.4	2.9	-0.1	-1.7
Major Depression (MDD)	1.1	1.3	2.6	-1.6	-0.1
Forced vital capacity (FVC)	1.1	4.2	8.2	-0.4	2.9
Financial situation satisfaction	1.1	1.3	2.3	-1.5	-0.5
Prostate Cancer	1.0	1.4	2.3	1.5	0.7
Nervous feelings	1.0	1.9	2.6	1.6	1.1
Forced expiratory volume in 1-second (FEV1)	1.0	3.2	6.4	-0.0	2.5
Depression (self-reported)	1.0	1.2	2.2	1.5	-0.3
Medication: Seretide 50 evohaler	1.0	1.1	2.1	-1.5	0.4
Supplements: Vitamin C	1.0	1.2	2.1	-1.4	-0.5
Osteoporosis (self-reported)	1.0	1.2	2.4	-1.6	-0.2
Sensitivity / hurt feelings	0.9	1.5	1.7	1.3	1.2
Average weekly fortified wine intake	0.9	1.0	2.0	-0.2	1.4
Medication: Simvastatin	0.9	1.3	2.3	1.5	0.5
Hip circumference	0.9	4.0	5.3	-1.6	2.3
Pulse rate	0.9	1.5	2.6	1.6	0.6
Age at first live birth	0.9	1.6	2.9	-0.6	1.7
Family relationship satisfaction	0.9	1.1	2.1	-0.4	1.4
Smoking status: Current	0.9	1.4	1.6	-1.3	-1.0
High cholesterol (Self-reported)	0.9	1.6	2.8	-0.6	-1.7
Alcohol drinker status: Never	0.9	1.1	1.8	1.3	-0.6
Diastolic blood pressure, automated reading	0.9	2.6	3.1	-1.5	1.8
Mean Putamen Volume	0.8	0.9	1.7	-0.3	-1.3
HDL Cholesterol	0.8	1.3	2.6	-1.6	-0.2
Type 2 Diabetes (T2D) (2018)	0.8	1.6	2.2	1.5	-1.0
Relative age of first facial hair	0.8	1.5	3.0	-1.7	0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.6	0.4	-1.2
High blood pressure (mother)	0.8	1.2	2.1	-1.4	-0.5
Number of live births	0.8	1.1	2.0	-0.5	-1.4
Noisy workplace	0.8	1.0	1.4	-0.7	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	1.3	-0.8	-1.1
Number of children fathered	0.8	0.9	1.4	1.2	0.6
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.6	1.3	-0.5
Pulse rate, automated reading	0.8	2.7	5.2	2.3	-0.5
Illnesses of siblings: Diabetes	0.8	1.0	2.0	1.4	0.0
Commuting to job workplace: Public transport	0.8	1.0	1.3	-0.8	-1.2
Number of operations (self-reported)	0.8	1.2	1.5	1.2	1.0
Alzheimer’s Disease (in father)	0.7	0.7	0.9	1.0	0.7
HbA1C	0.7	0.7	1.2	-1.1	0.5
Lupus	0.7	1.1	1.1	1.0	-1.0
Primary Biliary Cirrhosis	0.7	1.0	1.8	0.4	1.3
Waist Hip Ratio (WHR)	0.7	3.0	4.7	2.2	-1.2
Diabetes (father)	0.7	0.8	1.6	-0.2	-1.3
Taking other prescription medications	0.7	1.0	1.1	0.9	1.1
Diabetes (self-reported)	0.7	1.1	1.5	0.8	-1.2
Happiness	0.7	0.9	1.7	-1.3	0.1
Medication: Aspirin	0.7	0.8	1.0	-1.0	0.9
Average weekly champagne plus white wine intake	0.7	1.0	1.5	-1.2	0.8
Supplements: Calcium	0.7	0.8	1.4	-1.2	-0.4
Depression (Nagel 2018)	0.6	0.9	1.9	-0.2	-1.4
Schizophrenia (2018)	0.6	1.2	1.3	1.0	1.1
Ulcerative Colitis (UC)	0.6	1.1	2.2	-1.5	0.2
Crohns Disease (2012)	0.6	1.0	1.7	-0.6	-1.3
Fasting Glucose	0.6	0.7	1.3	-1.1	-0.3
Current tobacco smoking	0.6	1.0	1.0	-1.0	-1.0
Multivitamins +/- minerals	0.6	0.7	0.9	-1.0	-0.7
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	-0.1	-1.2
Heart attack	0.6	0.8	0.8	0.9	-0.9
Alcohol intake versus 10 years previously	0.6	0.9	1.7	0.3	-1.3
Medication: Lansoprazole	0.6	0.7	1.3	1.1	0.3
Breastfed as a baby	0.6	0.7	1.3	-0.4	1.2
Tense / ‘highly strung’	0.6	1.0	1.8	1.3	-0.5
Gout (self-reported)	0.6	0.8	1.3	-0.6	1.1
Medication: Blood pressure	0.6	1.1	2.0	1.4	-0.5
Heart disease (mother)	0.6	0.8	1.5	-0.3	-1.2
Had major operations	0.6	0.8	0.9	0.9	0.8
Age at last live birth	0.6	0.9	1.4	-1.2	0.6
Ever had bowel cancer screening	0.6	0.7	1.0	0.6	-1.0
Diabetes diagnosed by doctor	0.6	0.9	1.0	0.9	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.2	1.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	2.0	0.6	1.4
Medication: Paracetamol	0.6	1.0	1.9	-0.3	1.4
Alcohol drinker status: Previous	0.6	0.7	1.1	-1.1	-0.5
Cardiovascular Disease	0.5	1.6	2.7	-1.6	-0.7
Number of treatments/medications taken	0.5	0.9	1.8	-0.1	1.4
Fed-up feelings	0.5	1.0	1.3	0.8	1.1
Qualifications: CSEs or equivalent	0.5	0.7	1.1	0.5	1.1
Fluid intelligence score	0.5	0.9	0.9	1.0	1.0
Illnesses of siblings	0.5	0.6	0.8	-0.7	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.7	1.1	1.1	0.5
Hair/balding pattern: Pattern 4	0.5	1.2	2.3	1.5	0.4
Worry too long after embarrassment	0.5	0.8	1.4	1.2	-0.3
Medication: Allopurinol	0.5	0.7	1.3	-1.2	-0.2
Leg pain on walking	0.5	0.7	1.3	-0.0	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	0.8	0.5	0.9
Qualifications: nursing, teaching	0.5	0.8	1.5	0.4	-1.2
Ever smoked	0.5	0.9	1.7	-1.3	0.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	0.2	1.1
Worry (Nagel 2018)	0.4	0.9	1.7	-1.3	-0.0
Alzheimer’s Disease (including proxy)	0.4	0.5	0.9	-0.3	-1.0
Breast Cancer	0.4	1.0	2.0	0.2	-1.4
Coronary Artery Disease (CAD)	0.4	0.5	1.0	-0.1	1.0
LDL Cholesterol	0.4	0.6	1.1	0.4	-1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.6	-0.8	-0.6
Lung FEV1/FVC ratio	0.4	1.8	3.1	-0.8	-1.8
Frequency of depressed mood in last 2 weeks	0.4	0.6	0.9	0.5	-0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	0.3	-1.0
Vitamin and mineral supplements	0.4	0.6	0.6	0.8	0.7
Supplements: Glucosamine	0.4	0.5	1.0	0.2	1.0
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	0.8	-0.2	-0.9
Body mass index (BMI)	0.4	1.7	3.1	-1.8	0.6
Hair/balding pattern: Pattern 2	0.4	0.6	0.6	-0.8	0.7
Medication: Cholesterol lowering	0.4	0.6	0.8	0.9	0.6
Arm fat mass (right)	0.4	1.7	1.8	-1.4	1.3
Length of working week for main job	0.4	0.4	0.6	0.5	0.8
Pulse wave reflection index	0.4	0.5	0.8	0.5	-0.9
Comparative body size at age 10	0.4	1.2	2.4	-1.6	-0.1
Leg fat mass (right)	0.4	1.4	1.4	-1.2	1.1
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	-0.1	1.0
Knee pain experienced in last month	0.4	0.7	1.0	1.0	0.6
Arm fat mass (left)	0.4	1.8	1.9	-1.4	1.3
Wears glasses or contact lenses	0.4	0.4	0.6	-0.8	-0.5
Mother’s age at death	0.4	0.5	0.7	-0.5	-0.9
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.9	-0.5
Commuting to job workplace: Cycle	0.4	0.4	0.6	0.5	0.8
Cholesterol lowering medication	0.4	0.6	1.0	1.0	-0.4
Pain experienced in last month	0.4	0.7	0.9	0.7	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-1.0	0.1
Leg fat mass (left)	0.4	1.4	2.0	-1.4	0.9
Irritable Bowel Disease (IBD)	0.3	0.6	1.3	-1.1	-0.1
Ovarian Cancer	0.3	0.5	0.6	-0.6	-0.8
Allergy or Eczema	0.3	0.8	1.5	1.2	0.2
Lung FVC	0.3	1.6	2.3	-1.0	-1.5
Supplements: Zinc	0.3	0.4	0.4	-0.7	0.6
Diabetes (mother)	0.3	0.4	0.8	0.9	0.1
Past tobacco smoking	0.3	0.6	0.9	0.9	0.5
Mouth/teeth dental problems	0.3	0.4	0.5	0.7	0.6
Falls in the last year	0.3	0.4	0.7	-0.8	-0.1
Birth weight of first child	0.3	0.5	1.0	-1.0	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.4	0.6	0.5
Blood clot in the leg (DVT)	0.3	0.3	0.7	-0.8	-0.1
Exposure to tobacco smoke outside home	0.3	0.5	0.9	0.0	-1.0
Whole body fat mass	0.3	1.1	1.3	-1.1	1.0
Overall health rating	0.3	0.6	1.1	1.0	-0.3
Medication: Aspirin	0.3	0.3	0.6	-0.2	0.8
Smoking status: Previous	0.3	0.5	0.7	-0.6	-0.8
Illnesses of father: None of the above (group 1)	0.3	0.4	0.6	-0.8	0.4
Guilty feelings	0.3	0.5	1.0	-1.0	0.2
Medication: Blood pressure	0.3	0.5	1.0	-0.3	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.5	-0.7	-0.6
Leg fat percentage (left)	0.3	1.1	1.3	-1.1	-1.0
Irritability	0.3	0.5	0.9	0.1	1.0
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.8	-0.5
Bipolar Disorder or Schizophrenia	0.2	0.6	0.8	0.9	0.6
Crohns Disease (2017)	0.2	0.4	0.8	-0.2	-0.9
Reaction Time	0.2	0.5	0.8	0.9	-0.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.1	0.3	-1.0
Triglycerides	0.2	0.3	0.4	0.6	0.4
Hair Pigment	0.2	4.7	8.5	0.9	2.9
Systolic blood pressure, automated reading	0.2	0.5	1.0	-1.0	0.2
Trunk fat percentage	0.2	0.7	0.8	-0.8	-0.9
Relative age voice broke	0.2	0.3	0.5	-0.7	0.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.5	0.0	-0.7
Serious illness, injury or assault to yourself	0.2	0.3	0.3	0.6	-0.4
Medication: Atenolol	0.2	0.2	0.4	0.3	-0.6
Trunk fat mass	0.2	1.0	1.4	-1.2	0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.3	-0.5	-0.6
Time employed in main current job	0.2	0.3	0.5	0.1	-0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.8	0.1
Lung cancer (father)	0.2	0.2	0.2	0.4	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.6	-0.8	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.4	-0.7	0.5
Glaucoma (self-reported)	0.2	0.2	0.3	-0.6	0.3
Medication: Amlodipine	0.2	0.3	0.4	-0.6	-0.4
Body fat percentage	0.2	0.7	0.7	-0.9	-0.8
Leg fat percentage (right)	0.2	0.6	0.7	-0.7	-0.8
Health satisfaction	0.2	0.2	0.4	-0.1	0.6
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.3	-0.7
Chest pain or discomfort	0.2	0.4	0.7	0.8	-0.3
Average weekly red wine intake	0.2	0.4	0.4	-0.6	0.6
Back pain experienced in last month	0.2	0.4	0.7	0.1	0.8
Asthma (self-reported)	0.2	0.4	0.6	-0.6	0.7
Miserableness	0.2	0.4	0.8	-0.9	-0.0
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.6	0.5
Medication: Bendroflumethiazide	0.2	0.2	0.3	0.6	-0.4
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.2	0.7
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.4	-0.3	-0.6
Neuroticism (Nagel 2018)	0.1	0.2	0.2	-0.3	0.5
Bipolar Disorder (2011)	0.1	0.1	0.2	0.4	0.2
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	0.3
Schizophrenia (2014)	0.1	0.1	0.3	0.1	0.5
Blood Eosinophil Count	0.1	1.0	1.0	-1.0	-1.0
Blood White Count	0.1	0.5	0.6	-0.7	-0.7
Heel T-Score	0.1	1.1	2.1	-0.4	-1.4
BMI	0.1	0.8	1.6	-1.2	0.2
Respiratory disease	0.1	0.2	0.4	0.3	0.6
Angina	0.1	0.1	0.2	0.2	-0.5
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.4	0.1
Maternal smoking around birth	0.1	0.2	0.2	-0.5	0.3
Age when periods started (menarche)	0.1	0.3	0.7	-0.1	0.8
Waist circumference	0.1	0.4	0.6	-0.5	0.8
Number of incorrect matches in round	0.1	0.1	0.2	-0.5	-0.0
Alcohol usually taken with meals	0.1	0.1	0.2	0.2	0.4
Hearing difficulty/problems with background noise	0.1	0.2	0.4	0.2	-0.6
Had other major operations	0.1	0.1	0.1	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.5	-0.4
Qualifications: None of the above	0.1	0.3	0.3	0.6	-0.4
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.1	-0.2	-0.3
Neuroticism score	0.1	0.2	0.4	0.2	0.6
Arm fat percentage (right)	0.1	0.3	0.6	-0.8	-0.3
Worrier / anxious feelings	0.1	0.3	0.5	-0.7	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	0.4	-0.4
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	-0.3	0.5
Asthma	0.1	0.2	0.3	-0.4	0.5
Loud music exposure frequency	0.1	0.1	0.2	0.4	0.2
High blood pressure (siblings)	0.1	0.2	0.2	-0.4	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.1	-0.3	-0.3
Qualifications: College or University degree	0.1	0.2	0.3	0.5	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.5	0.3
Angina (self-reported)	0.1	0.1	0.2	0.5	-0.2
Alcohol intake frequency.	0.1	0.1	0.2	-0.2	-0.4
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.2	-0.4	0.2
Hypertension (Self-reported)	0.1	0.2	0.4	0.3	-0.6
Arm fat percentage (left)	0.1	0.3	0.6	-0.8	-0.2
Mood swings	0.1	0.2	0.4	-0.6	0.1
Loneliness, isolation	0.1	0.1	0.2	0.4	0.1
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	0.5	0.1
Average weekly beer plus cider intake	0.1	0.1	0.2	0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.1	0.3	0.6	0.1	0.8
Heart disease (siblings)	0.1	0.1	0.1	-0.3	-0.3
Bipolar Disorder (2018)	0.0	0.1	0.1	0.1	-0.4
Body Mass Index (BMI) (2010)	0.0	0.0	0.0	0.2	-0.0
Blood Red Count	0.0	0.3	0.6	0.2	0.8
Neuroticism	0.0	0.1	0.2	-0.1	0.4
Tanning	0.0	0.0	0.1	-0.3	-0.1
Average weekly spirits intake	0.0	0.0	0.0	-0.1	0.2
Medication: Metformin	0.0	0.0	0.1	-0.0	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.1	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	0.2	-0.4
High blood pressure	0.0	0.1	0.1	0.2	-0.3
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.2	0.4	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	0.1
Financial difficulties in last 2 years	0.0	0.0	0.0	-0.0	-0.1
Allergy	0.0	0.0	0.0	-0.0	-0.2
Father’s age at death	0.0	0.0	0.0	-0.1	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	0.1	0.1
Number of full brothers	0.0	0.0	0.1	0.0	-0.3
Wheeze or whistling in the chest in last year	0.0	0.0	0.1	-0.1	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.2	0.0
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	-0.2	-0.0
Medication for cholesterol	0.0	0.0	0.0	0.0	0.1
Mineral and other dietary supplements	0.0	0.0	0.0	-0.1	0.1
Ever taken oral contraceptive pill	0.0	0.0	0.0	0.2	-0.1
Hearing aid user	0.0	0.1	0.1	-0.3	0.2
Illnesses of father: High blood pressure	0.0	0.0	0.0	0.1	0.2
Unable to work because of sickness or disability	0.0	0.1	0.1	0.3	0.1
Myopia	0.0	0.1	0.1	-0.3	-0.1

Hub : Genes

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Trait associations