Best TWAS P=2.43e-09 · Best GWAS P=1.7e-13 conditioned to 2.56e-09
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PDCD5 | 0.26 | 0.13 | bslmm | 403 | 0.22 | 9.5e-26 | -5.0 | -5.8 | 4.8e-09 | -0.23 | 0.91 | 0.09 | FALSE |
2 | GTEx | Adipose Subcutaneous | PDCD5 | 0.16 | 0.03 | enet | 25 | 0.11 | 3.7e-09 | 1.0 | -5.6 | 1.9e-08 | -0.07 | 0.37 | 0.06 | FALSE |
3 | GTEx | Adipose Visceral Omentum | PDCD5 | 0.16 | 0.04 | enet | 33 | 0.10 | 7.9e-06 | 4.5 | -5.2 | 1.7e-07 | 0.02 | 0.08 | 0.04 | FALSE |
4 | GTEx | Brain Cerebellar Hemisphere | PDCD5 | 0.33 | -0.01 | enet | 39 | 0.00 | 4.4e-01 | 3.8 | -5.3 | 1.4e-07 | -0.23 | 0.04 | 0.14 | FALSE |
5 | GTEx | Brain Hippocampus | PDCD5 | 0.36 | 0.04 | enet | 16 | 0.14 | 3.9e-04 | -4.1 | -5.2 | 2.5e-07 | -0.21 | 0.14 | 0.09 | FALSE |
6 | GTEx | Cells Transformed fibroblasts | PDCD5 | 0.23 | 0.08 | lasso | 7 | 0.17 | 6.5e-13 | -5.0 | -5.5 | 3.7e-08 | -0.07 | 0.97 | 0.02 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | RHPN2 | 0.08 | 0.00 | enet | 12 | 0.01 | 1.2e-01 | 3.8 | -5.3 | 1.2e-07 | -0.07 | 0.18 | 0.04 | FALSE |
8 | GTEx | Esophagus Mucosa | PDCD5 | 0.09 | 0.00 | enet | 13 | 0.01 | 5.0e-02 | -5.0 | -5.2 | 2.4e-07 | -0.07 | 0.10 | 0.04 | FALSE |
9 | GTEx | Testis | PDCD5 | 0.18 | 0.08 | lasso | 5 | 0.12 | 6.0e-06 | 6.4 | -6.0 | 2.4e-09 | -0.07 | 0.21 | 0.12 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DPY19L3 | 0.04 | 0.03 | blup | 60 | 0.02 | 2.2e-03 | -3.3 | -5.1 | 2.7e-07 | -0.23 | 0.19 | 0.04 | TRUE |
11 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PDCD5 | 0.09 | 0.04 | blup | 59 | 0.07 | 1.0e-08 | -5.0 | -5.2 | 2.5e-07 | -0.14 | 0.13 | 0.85 | FALSE |
12 | The Cancer Genome Atlas | Lung Adenocarcinoma | PDCD5 | 0.04 | 0.00 | enet | 8 | 0.01 | 9.2e-03 | -5.0 | -5.3 | 1.0e-07 | -0.07 | 0.01 | 0.48 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PDCD5 | 0.12 | 0.07 | enet | 12 | 0.09 | 1.6e-09 | -5.0 | -5.2 | 2.0e-07 | -0.08 | 0.03 | 0.97 | FALSE |