Best TWAS P=2.36e-24 · Best GWAS P=5.24e-18 conditioned to 1.42e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C2orf40 | 0.20 | 0.11 | bslmm | 483 | 0.13 | 7.8e-16 | 5.6 | -10.2 | 2.4e-24 | 0.02 | 0.95 | 0.05 | TRUE |
| 2 | GTEx | Muscle Skeletal | C2orf40 | 0.30 | 0.05 | lasso | 6 | 0.14 | 6.2e-14 | -4.4 | -6.9 | 5.3e-12 | 0.05 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Nerve Tibial | C2orf40 | 0.34 | 0.01 | enet | 27 | 0.11 | 1.9e-08 | 5.6 | -7.2 | 4.4e-13 | 0.03 | 0.45 | 0.29 | FALSE |
| 4 | METSIM | Adipose | C2orf40 | 0.17 | 0.04 | blup | 472 | 0.09 | 1.3e-13 | 4.9 | -6.5 | 6.5e-11 | 0.00 | 0.19 | 0.81 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C2orf40 | 0.06 | 0.02 | blup | 79 | 0.02 | 1.3e-05 | 5.7 | -5.7 | 1.3e-08 | 0.00 | 0.12 | 0.06 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2orf40 | 0.06 | 0.01 | blup | 79 | 0.04 | 3.1e-05 | 4.6 | -5.4 | 8.0e-08 | 0.06 | 0.06 | 0.13 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | UXS1 | 0.06 | 0.01 | lasso | 3 | 0.01 | 7.3e-03 | -4.5 | -6.2 | 8.0e-10 | -0.05 | 0.02 | 0.04 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf40 | 0.08 | 0.00 | blup | 79 | 0.02 | 4.7e-03 | 2.0 | -6.8 | 1.0e-11 | -0.01 | 0.01 | 0.47 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UXS1 | 0.04 | 0.03 | enet | 4 | 0.02 | 1.1e-03 | -5.3 | -8.2 | 1.7e-16 | 0.01 | 0.03 | 0.23 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TGFBRAP1 | 0.03 | 0.01 | blup | 91 | 0.02 | 7.4e-03 | 5.9 | -5.4 | 8.0e-08 | -0.66 | 0.01 | 0.80 | TRUE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | C2orf40 | 0.11 | 0.02 | blup | 79 | 0.05 | 8.9e-06 | 5.6 | -6.6 | 4.0e-11 | 0.06 | 0.23 | 0.06 | FALSE |