Best TWAS P=2.63e-12 · Best GWAS P=2.03e-11 conditioned to 0.389
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GCC2 | 0.12 | 0.17 | enet | 30 | 0.18 | 5.1e-21 | 6.2 | 5.9 | 3.9e-09 | 0.91 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | GCC2 | 0.36 | 0.46 | enet | 23 | 0.45 | 5.8e-40 | -5.9 | 5.2 | 2.2e-07 | 0.61 | 0.48 | 0.52 | FALSE |
3 | GTEx | Adipose Visceral Omentum | GCC2 | 0.25 | 0.27 | lasso | 11 | 0.22 | 9.8e-12 | -5.7 | 5.7 | 1.4e-08 | 0.69 | 0.67 | 0.33 | FALSE |
4 | GTEx | Artery Aorta | GCC2 | 0.09 | 0.03 | lasso | 11 | 0.02 | 3.3e-02 | -5.9 | 5.9 | 3.8e-09 | 0.65 | 0.16 | 0.53 | FALSE |
5 | GTEx | Artery Aorta | LIMS1 | 0.17 | 0.11 | lasso | 4 | 0.10 | 5.0e-06 | -5.6 | 6.2 | 5.1e-10 | 0.68 | 0.36 | 0.56 | FALSE |
6 | GTEx | Artery Coronary | GCC2 | 0.31 | 0.26 | lasso | 4 | 0.18 | 8.8e-07 | -5.9 | 5.8 | 8.0e-09 | 0.67 | 0.56 | 0.44 | FALSE |
7 | GTEx | Artery Tibial | AC012487.2 | 0.06 | 0.03 | enet | 21 | 0.01 | 2.5e-02 | 6.4 | 6.2 | 5.1e-10 | 0.67 | 0.05 | 0.80 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | GCC2 | 0.22 | -0.01 | lasso | 7 | -0.01 | 8.2e-01 | 6.2 | -5.8 | 6.2e-09 | -0.83 | 0.03 | 0.76 | FALSE |
9 | GTEx | Brain Cerebellum | GCC2 | 0.17 | 0.10 | enet | 16 | 0.08 | 2.4e-03 | 6.4 | 6.5 | 1.0e-10 | 0.94 | 0.03 | 0.93 | FALSE |
10 | GTEx | Breast Mammary Tissue | GCC2 | 0.31 | 0.32 | lasso | 8 | 0.31 | 1.6e-16 | -5.7 | 5.5 | 2.9e-08 | 0.65 | 0.68 | 0.32 | FALSE |
11 | GTEx | Breast Mammary Tissue (Female) | GCC2 | 0.28 | 0.31 | lasso | 10 | 0.28 | 6.4e-09 | -5.7 | 5.7 | 1.2e-08 | 0.68 | 0.64 | 0.36 | FALSE |
12 | GTEx | Cells Transformed fibroblasts | GCC2 | 0.19 | 0.16 | enet | 14 | 0.18 | 3.4e-13 | -5.7 | 5.7 | 1.5e-08 | 0.67 | 0.66 | 0.34 | FALSE |
13 | GTEx | Esophagus Gastroesophageal Junction | GCC2 | 0.16 | 0.14 | lasso | 9 | 0.12 | 5.8e-05 | -5.7 | 5.7 | 9.9e-09 | 0.68 | 0.47 | 0.41 | FALSE |
14 | GTEx | Esophagus Gastroesophageal Junction | AC012487.2 | 0.14 | 0.01 | enet | 14 | 0.07 | 1.7e-03 | 6.7 | 5.9 | 3.4e-09 | 0.74 | 0.03 | 0.79 | FALSE |
15 | GTEx | Esophagus Mucosa | GCC2 | 0.24 | 0.28 | enet | 22 | 0.28 | 3.0e-19 | -5.2 | 6.0 | 2.4e-09 | 0.67 | 0.65 | 0.35 | FALSE |
16 | GTEx | Esophagus Muscularis | GCC2 | 0.18 | 0.18 | lasso | 3 | 0.20 | 3.8e-12 | -5.9 | 6.1 | 1.3e-09 | 0.66 | 0.59 | 0.41 | FALSE |
17 | GTEx | Esophagus Muscularis | LIMS1 | 0.10 | 0.00 | lasso | 3 | 0.00 | 2.4e-01 | 6.0 | 6.0 | 2.4e-09 | 0.87 | 0.06 | 0.81 | FALSE |
18 | GTEx | Heart Atrial Appendage | GCC2 | 0.14 | 0.14 | lasso | 1 | 0.11 | 1.5e-05 | -5.9 | 5.9 | 3.2e-09 | 0.68 | 0.43 | 0.50 | FALSE |
19 | GTEx | Lung | GCC2 | 0.21 | 0.29 | lasso | 3 | 0.29 | 3.7e-22 | -5.6 | 5.6 | 1.9e-08 | 0.67 | 0.66 | 0.34 | FALSE |
20 | GTEx | Muscle Skeletal | GCC2 | 0.05 | 0.04 | lasso | 9 | 0.03 | 1.2e-03 | -5.9 | 5.6 | 2.0e-08 | 0.67 | 0.41 | 0.30 | FALSE |
21 | GTEx | Nerve Tibial | GCC2 | 0.27 | 0.28 | lasso | 10 | 0.27 | 2.8e-19 | -5.1 | 6.1 | 8.1e-10 | 0.76 | 0.63 | 0.37 | FALSE |
22 | GTEx | Skin Not Sun Exposed Suprapubic | GCC2 | 0.21 | 0.30 | lasso | 4 | 0.28 | 8.8e-16 | -5.9 | 6.0 | 1.6e-09 | 0.67 | 0.53 | 0.47 | FALSE |
23 | GTEx | Skin Sun Exposed Lower leg | GCC2 | 0.30 | 0.29 | lasso | 10 | 0.32 | 3.2e-27 | -5.9 | 5.8 | 9.2e-09 | 0.67 | 0.54 | 0.46 | FALSE |
24 | GTEx | Spleen | GCC2 | 0.41 | 0.33 | lasso | 7 | 0.31 | 9.9e-09 | -5.7 | 5.7 | 9.2e-09 | 0.69 | 0.63 | 0.35 | FALSE |
25 | GTEx | Stomach | GCC2 | 0.17 | 0.21 | lasso | 11 | 0.22 | 5.6e-11 | -5.7 | 5.7 | 1.4e-08 | 0.69 | 0.48 | 0.52 | FALSE |
26 | GTEx | Stomach | AC012487.2 | 0.08 | 0.02 | enet | 19 | 0.05 | 2.2e-03 | -5.2 | 6.9 | 6.0e-12 | 0.82 | 0.04 | 0.93 | FALSE |
27 | GTEx | Thyroid | GCC2 | 0.24 | 0.19 | enet | 27 | 0.19 | 3.1e-14 | -5.7 | 5.1 | 2.9e-07 | 0.63 | 0.67 | 0.33 | FALSE |
28 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LIMS1 | 0.02 | 0.01 | blup | 54 | 0.02 | 4.1e-03 | -5.8 | -6.5 | 9.9e-11 | -0.87 | 0.03 | 0.77 | FALSE |
29 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LIMS1 | 0.03 | 0.01 | blup | 54 | 0.03 | 4.4e-04 | 6.7 | 7.0 | 2.6e-12 | 0.91 | 0.02 | 0.95 | TRUE |