Best TWAS P=9.71e-25 · Best GWAS P=3.1e-21 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IL1R1 | 0.14 | 0.09 | lasso | 3 | 0.10 | 4.0e-12 | -6.0 | 6.0 | 1.5e-09 | -0.16 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | IL1R1 | 0.13 | 0.04 | enet | 26 | 0.06 | 9.8e-04 | -3.7 | -7.0 | 2.3e-12 | 0.53 | 0.19 | 0.07 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | IL18R1 | 0.05 | 0.02 | lasso | 6 | 0.02 | 7.4e-03 | -4.8 | -5.2 | 1.8e-07 | 0.47 | 0.46 | 0.03 | FALSE |
| 4 | NTR | Blood | IL18RAP | 0.14 | 0.16 | lasso | 7 | 0.19 | 1.1e-59 | -4.8 | 5.6 | 1.9e-08 | -0.35 | 1.00 | 0.00 | FALSE |
| 5 | NTR | Blood | IL1RL1 | 0.04 | 0.04 | lasso | 6 | 0.04 | 7.7e-13 | -4.9 | 6.2 | 6.6e-10 | -0.56 | 1.00 | 0.00 | FALSE |
| 6 | YFS | Blood | IL18R1 | 0.19 | 0.10 | blup | 573 | 0.17 | 7.9e-53 | -8.3 | 10.3 | 9.7e-25 | -0.71 | 0.99 | 0.01 | TRUE |
| 7 | YFS | Blood | IL18RAP | 0.41 | 0.55 | bslmm | 562 | 0.62 | 4.2e-269 | -4.8 | 5.8 | 5.8e-09 | -0.38 | 1.00 | 0.00 | FALSE |
| 8 | YFS | Blood | IL1R1 | 0.06 | 0.02 | enet | 29 | 0.04 | 1.1e-13 | 1.3 | 5.5 | 3.3e-08 | -0.30 | 1.00 | 0.00 | TRUE |
| 9 | The Cancer Genome Atlas | Colon Adenocarcinoma | IL1R2 | 0.10 | 0.04 | lasso | 6 | 0.04 | 3.2e-03 | 5.4 | -5.3 | 1.2e-07 | 0.16 | 0.08 | 0.52 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IL1R2 | 0.03 | 0.01 | blup | 87 | 0.02 | 2.5e-03 | 2.2 | -5.3 | 1.0e-07 | 0.15 | 0.04 | 0.45 | TRUE |
| 11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IL18RAP | 0.03 | 0.02 | blup | 94 | 0.02 | 1.2e-03 | 2.7 | -6.4 | 1.8e-10 | 0.45 | 0.07 | 0.11 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IL18R1 | 0.25 | 0.29 | blup | 108 | 0.31 | 1.6e-35 | 3.6 | -5.3 | 1.2e-07 | 0.43 | 0.93 | 0.02 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | IL18RAP | 0.03 | 0.03 | lasso | 3 | 0.01 | 7.7e-03 | -4.8 | 5.6 | 2.6e-08 | -0.47 | 0.14 | 0.10 | FALSE |
| 14 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | IL1R2 | 0.32 | 0.08 | enet | 10 | 0.20 | 1.3e-08 | 5.8 | -5.8 | 8.2e-09 | 0.19 | 0.05 | 0.94 | TRUE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | IL1R2 | 0.07 | 0.05 | lasso | 3 | 0.06 | 2.5e-05 | 5.9 | -6.3 | 3.2e-10 | 0.16 | 0.02 | 0.98 | TRUE |