Hub : Genes

LIMS1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0750	0.0290	8.3e-04	0.005	0.024	0.011	0.021	0.011	7.1e-02	0.00056	0.01400	0.0011	1.4e-02
2	GTEx	Artery Aorta	0.1680	0.0540	6.2e-05	0.106	NA	0.038	NA	0.097	1.8e-06	NA	0.00370	NA	5.0e-06
3	GTEx	Esophagus Muscularis	0.1010	0.0490	4.7e-03	0.001	NA	-0.004	NA	0.002	2.9e-01	NA	0.70000	NA	2.4e-01
4	GTEx	Pancreas	0.1690	0.0620	1.9e-03	0.049	NA	0.089	NA	0.073	3.9e-03	NA	0.00014	NA	5.2e-04
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0203	0.0134	2.9e-03	0.009	0.017	0.012	NA	0.009	2.7e-02	0.00410	0.01400	NA	2.7e-02
6	TCGA	Prostate Adenocarcinoma	0.0278	0.0174	6.2e-04	0.013	0.029	0.023	NA	0.024	1.5e-02	0.00044	0.00160	NA	1.4e-03
7	TCGA	Thyroid Carcinoma	0.0720	0.0450	2.8e-04	0.036	0.032	0.032	NA	0.032	1.9e-04	0.00037	0.00043	NA	4.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	1.1	1.0	1.1	1.0	-0.1	-1.0	1.0	-0.6
Bipolar Disorder or Schizophrenia	0.7	1.7	3.4	0.3	1.9	0.9	0.8	-1.4	1.2	-1.8
Depressed Affect (Nagel 2018)	1.2	2.4	5.7	1.1	0.8	2.4	-2.1	-1.6	1.7	0.1
Depression (Nagel 2018)	0.6	1.0	2.3	0.6	0.4	1.4	-1.5	-0.8	0.9	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	-1.1	0.3	0.9	-1.2	-0.8	1.0	-0.0
Neuroticism (Nagel 2018)	0.8	1.9	4.4	0.7	0.3	1.9	-2.1	-1.2	1.6	0.7
Schizophrenia (2018)	0.6	1.3	3.3	-0.4	1.5	0.3	1.2	-1.0	0.8	-1.8
Schizophrenia vs Biploar Disorder	0.4	0.5	0.8	0.7	0.3	0.9	0.5	-0.7	0.6	-0.9
Worry (Nagel 2018)	0.1	0.2	0.4	0.2	0.3	0.2	-0.5	-0.3	0.6	0.4
Alzheimer’s Disease (in mother)	0.1	0.1	0.5	-0.3	0.1	-0.7	0.1	0.1	0.3	0.0
Alzheimer’s Disease (in father)	2.0	2.1	4.5	-1.3	-1.6	-0.6	-1.4	1.4	-1.4	2.1
Alzheimer’s Disease (including proxy)	1.6	2.4	4.3	-0.8	-1.8	-1.7	-0.7	1.8	-1.4	2.1
Crohns Disease (2017)	0.4	0.8	2.7	0.6	-0.7	0.7	-1.6	0.2	-0.4	1.3
Irritable Bowel Disease (IBD)	0.4	0.9	1.5	1.1	0.9	1.2	-1.2	-0.9	0.8	-0.0
Ulcerative Colitis (UC)	1.2	2.2	4.0	1.6	2.0	1.4	-0.4	-1.7	1.6	-1.2
Major Depression (MDD)	0.2	0.2	0.3	0.3	0.5	0.5	-0.5	-0.6	0.5	-0.2
Reaction Time	0.4	0.8	1.4	-0.4	-0.7	-1.2	0.1	1.2	-1.1	1.0
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.4	-0.1	1.0	1.2	-1.4	-1.2	1.5	-0.3
Breast Cancer	1.2	2.8	6.2	2.0	1.4	2.5	-0.3	-1.9	1.4	-1.2
Ovarian Cancer	0.7	0.9	2.0	-0.9	-1.4	-0.9	-0.6	0.9	-0.4	1.2
Prostate Cancer	0.8	1.1	2.7	-0.5	-0.8	-1.4	1.6	1.0	-1.0	-0.3
Age at First Birth	0.9	1.3	2.2	-1.3	-1.5	-0.9	0.3	1.3	-1.4	0.8
Bipolar Disorder (2011)	1.2	1.2	2.3	-1.5	1.4	-0.2	0.1	-1.0	1.0	-1.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	-0.0	-0.5	0.1	0.5	0.2	-0.4	0.3
Coronary Artery Disease (CAD)	0.4	0.5	2.2	0.6	-0.0	0.4	-1.5	-0.3	0.3	0.6
Crohns Disease (2012)	1.3	2.1	4.2	-0.1	-1.9	-0.9	-0.7	1.7	-1.7	2.0
Mean Putamen Volume	0.2	0.2	0.4	-0.2	-0.6	-0.3	0.3	0.5	-0.6	-0.0
Fasting Glucose	2.2	2.6	5.8	-1.2	-0.9	-2.4	1.9	1.8	-1.8	0.5
HbA1C	0.4	0.5	1.5	1.2	-0.4	-0.2	1.0	0.0	0.0	-0.7
HDL Cholesterol	0.2	0.3	0.9	-0.7	0.0	-0.9	1.0	0.2	-0.3	-0.2
LDL Cholesterol	4.2	6.7	18.7	-3.2	-0.3	-2.9	4.3	1.5	-1.9	-1.9
Lupus	0.2	0.3	1.0	-0.5	0.2	-0.6	1.0	0.1	-0.3	-0.7
Neuroticism (2016)	1.2	1.7	4.1	1.6	-0.0	2.0	-1.4	-1.2	1.3	0.5
Primary Biliary Cirrhosis	0.3	0.4	1.8	-1.3	0.3	-0.0	-0.6	-0.3	0.4	-0.5
Rheumatoid Arthritis	2.5	3.5	6.1	0.2	-2.4	-2.0	0.7	2.5	-2.4	1.7
Schizophrenia (2014)	0.9	2.0	5.1	-0.4	1.9	0.6	1.1	-1.4	1.2	-2.2
Triglycerides	0.1	0.1	0.4	-0.6	0.5	0.1	-0.3	-0.2	0.2	-0.1
Type 2 Diabetes (T2D) (2012)	1.3	1.5	5.4	0.6	0.3	1.5	-2.3	-0.8	0.9	0.9
Ulcerative Colitis	3.1	4.5	7.1	1.7	2.7	2.1	-0.7	-2.6	2.6	-1.8
Blood Eosinophil Count	0.5	3.6	12.0	0.6	-1.9	0.8	-2.8	0.7	-0.7	3.5
Blood Platelet Count	3.2	37.0	68.2	-1.7	-8.3	-5.5	1.6	7.7	-7.1	6.8
Blood Red Count	0.8	8.0	14.6	-2.3	-3.8	-2.0	0.1	3.2	-3.6	3.0
Blood White Count	0.3	2.0	7.3	-0.8	0.0	-1.1	2.7	0.7	-1.4	-1.6
Heel T-Score	0.6	4.4	9.2	-1.4	-1.5	-3.0	2.2	2.5	-2.5	0.4
BMI	0.6	3.6	6.6	-2.4	-2.0	-1.6	0.3	2.1	-2.6	1.2
Height	1.5	29.6	49.0	4.0	6.2	6.0	-4.1	-6.5	7.0	-3.0
Waist Hip Ratio (WHR)	0.2	1.1	5.2	0.3	-0.1	0.3	-2.3	0.1	0.1	1.6
Systolic Blood Pressure	0.2	0.9	2.2	1.0	0.8	1.5	-0.1	-1.2	0.6	-0.8
Smoking Status	1.0	2.5	5.5	1.9	1.0	2.4	-1.9	-1.5	1.0	0.2
Allergy or Eczema	0.2	0.5	0.9	-1.0	-0.9	-0.2	-0.1	0.7	-0.9	0.5
Cardiovascular Disease	0.3	1.0	2.2	-0.9	1.0	0.8	-0.5	-1.2	0.5	-1.5
Hypothyroidism (self reported)	0.9	2.1	3.4	1.6	0.8	1.8	-1.8	-1.2	1.7	0.3
Respiratory disease	0.3	0.7	2.6	0.2	-0.6	0.8	-1.6	-0.0	-0.1	1.1
Type 2 Diabetes (T2D) (2018)	1.9	3.5	7.6	-0.4	-2.7	-1.0	-1.2	2.0	-1.8	2.8
Lung FEV1/FVC ratio	0.4	1.8	4.5	0.5	0.8	1.3	-2.1	-1.5	1.8	-0.4
Lung FVC	0.8	4.0	6.2	-0.4	-2.3	-2.2	2.0	2.5	-2.5	1.3
Neuroticism	0.4	0.8	2.9	-0.0	-1.2	0.4	-1.0	0.5	-0.3	1.7
Chronotype (morning person)	0.7	1.7	4.0	-1.4	-0.7	-2.0	0.9	1.4	-1.6	-0.1
Hair Pigment	0.1	3.2	8.8	-0.6	-2.1	-0.1	-2.1	1.5	-1.5	3.0
Tanning	0.0	0.1	0.3	0.5	-0.3	0.0	-0.3	0.3	-0.5	0.5
Hand grip strength (left)	0.2	0.4	1.9	-1.4	0.2	-0.1	-0.2	-0.4	0.7	-0.5
Number of treatments/medications taken	4.6	8.3	16.3	0.7	4.0	2.5	-1.8	-3.6	3.4	-2.7
Average weekly spirits intake	0.6	0.7	1.7	-0.6	-0.9	-0.3	0.4	1.1	-1.3	0.7
Sensitivity / hurt feelings	0.8	1.4	2.4	0.5	1.2	1.5	-0.9	-1.6	1.6	-0.7
Frequency of depressed mood in last 2 weeks	1.9	2.6	6.4	1.5	0.5	2.0	-2.5	-1.3	1.7	0.9
Hearing difficulty/problems: Yes	0.5	0.7	1.9	-0.5	-1.3	-0.4	-0.4	0.8	-0.6	1.4
Relative age of first facial hair	1.0	2.1	5.7	-0.9	1.8	-0.0	1.9	-0.9	0.7	-2.4
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.6	-0.1	0.3	0.7	-0.6	-0.5	0.8	0.4
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.8	-0.4	0.9	0.2	-0.0	-0.4	0.4	-0.5
Ever had hysterectomy (womb removed)	1.3	1.5	2.5	-1.5	-1.0	-1.5	0.6	1.2	-1.6	0.8
Systolic blood pressure, automated reading	0.1	0.3	1.5	0.2	-0.2	0.2	1.2	0.1	-0.7	-0.6
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	7.0	2.6	0.7	2.0	-1.2	-1.2	1.2	0.2
Angina	2.2	2.8	5.0	1.0	1.6	2.2	-1.3	-2.1	2.2	-0.5
Medication for hormone replacement therapy	0.5	0.6	1.3	-1.0	1.1	-0.2	0.6	-0.3	0.3	-1.1
Vitamin and mineral supplements	1.0	1.3	2.3	0.1	-1.4	-1.3	-0.3	1.4	-1.1	1.5
Supplements: Zinc	0.2	0.3	0.7	-0.8	-0.1	-0.2	-0.8	0.4	-0.3	0.6
Medication: Co-codamol	1.1	1.3	2.8	0.9	0.7	1.4	-1.7	-1.1	1.3	0.3
Medication: Metformin	0.7	1.0	2.3	-1.5	-0.8	-0.5	-0.8	0.8	-0.7	1.3
Diabetes (father)	2.0	2.5	6.6	2.6	1.1	1.8	-1.4	-1.3	1.6	0.3
Diabetes (mother)	0.4	0.6	1.7	-0.5	0.8	0.2	-0.2	-1.0	1.3	-0.7
Severe depression (siblings)	0.3	0.4	1.7	-1.3	0.6	-0.5	0.3	-0.0	0.0	-0.5
Pack years adult smoking proportion	0.5	0.8	1.4	0.8	1.1	1.2	-0.1	-1.2	0.7	-0.8
Impedance of leg (right)	1.4	7.0	11.8	1.9	3.4	2.3	0.6	-3.1	3.0	-3.0
Leg fat-free mass (left)	0.1	0.6	3.1	-0.1	-0.5	0.3	-1.8	0.1	-0.2	0.8
Trunk fat percentage	0.1	0.3	1.0	-0.7	0.4	0.4	-1.0	-0.3	0.2	0.1
Hand grip strength (right)	0.4	1.2	3.1	-0.6	1.2	0.1	0.9	-1.0	1.2	-1.8
Townsend deprivation index at recruitment	1.2	1.6	4.0	2.0	0.2	2.0	-1.4	-1.0	0.8	0.3
Current tobacco smoking	3.4	5.5	13.4	2.8	1.6	3.7	-1.9	-2.5	2.1	-0.3
Average weekly fortified wine intake	0.5	0.6	0.9	-0.4	-0.9	-0.7	-0.9	0.8	-0.7	0.8
Maternal smoking around birth	1.3	1.8	2.9	1.4	1.0	1.7	-1.6	-1.4	1.5	-0.0
Fed-up feelings	2.1	3.7	9.2	1.8	0.6	3.0	-2.2	-2.0	2.1	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	4.4	1.4	-0.2	2.1	-2.0	-0.9	0.9	1.1
Relative age voice broke	0.7	1.0	3.4	-0.9	0.1	-1.0	1.8	0.6	-0.8	-1.1
Taking other prescription medications	2.3	3.5	5.2	1.3	2.3	2.0	-1.7	-2.2	2.0	-1.4
Age when periods started (menarche)	0.4	1.0	2.8	-0.5	1.2	0.2	0.9	-0.9	0.7	-1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	3.2	-1.8	-0.1	-1.5	1.2	0.8	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	4.9	-1.5	-1.8	-2.2	0.7	2.2	-2.0	1.1
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	4.5	2.1	0.8	1.3	-0.6	-0.9	0.8	-0.3
Qualifications: CSEs or equivalent	2.5	3.3	5.7	-0.4	-2.1	-2.0	1.5	2.4	-2.4	1.1
Serious illness, injury or assault to yourself	1.5	1.9	4.3	2.1	0.9	1.0	-1.9	-1.2	1.4	0.0
High blood pressure	0.2	0.6	1.2	-0.1	0.8	1.0	-0.5	-1.1	0.7	-0.7
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.7	0.2	-0.9	-0.0	-0.2	0.8	-0.8	0.9
Multivitamins +/- minerals	0.6	0.7	1.4	-0.3	1.2	0.9	0.4	-0.9	0.6	-1.2
Stomach or abdominal pain in last month	1.1	1.4	4.4	0.7	0.6	1.3	-2.1	-1.1	1.2	0.7
Supplements: Glucosamine	1.8	2.3	8.7	-3.0	-0.1	-1.4	1.6	0.9	-1.2	-0.8
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.8	-1.4	1.6	-0.6	1.3	-0.7	0.5	-2.4
Medication: Atenolol	2.4	3.0	6.4	0.5	1.5	1.9	-1.9	-2.2	2.5	-0.5
Medication: Levothyroxine sodium	0.6	1.1	3.1	1.8	0.0	0.7	-1.5	-0.2	0.6	1.2
Sitting height	0.8	5.7	9.1	2.6	1.6	2.7	-2.6	-2.7	3.0	-0.7
Chronic bronchitis/emphysema (father)	0.5	0.6	1.5	1.2	0.5	1.1	-0.5	-0.4	0.4	0.7
High blood pressure (mother)	0.4	0.6	1.2	-0.5	-1.0	-1.1	-0.4	0.7	-0.7	0.7
Body mass index (BMI)	0.3	1.1	2.8	-1.7	-0.9	-0.4	-0.8	0.9	-1.3	0.8
Impedance of leg (left)	0.9	4.3	6.7	2.0	2.6	2.0	0.2	-2.4	2.4	-1.9
Leg predicted mass (left)	0.1	0.6	3.1	-0.1	-0.5	0.3	-1.8	0.1	-0.1	0.8
Trunk fat mass	0.1	0.4	1.7	-0.5	0.4	0.7	-1.3	-0.5	0.3	0.0
Waist circumference	0.1	0.4	1.3	-1.2	0.1	0.3	-1.0	0.0	-0.3	0.3
Number of incorrect matches in round	0.8	1.3	2.9	-1.1	-1.0	-1.7	0.4	1.2	-1.1	0.9
Past tobacco smoking	0.4	0.6	1.9	1.4	0.5	0.6	0.5	-0.7	0.8	-0.8
Alcohol usually taken with meals	0.4	0.6	2.4	-1.5	0.6	-0.6	0.3	-0.2	0.5	-0.9
Nervous feelings	0.3	0.6	2.1	1.2	-0.6	0.1	-0.3	0.2	0.3	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.8	0.8	-1.1	0.7	-1.6	0.3	0.0	2.2
Hearing difficulty/problems with background noise	0.1	0.1	0.2	0.4	-0.3	0.3	0.5	0.1	-0.1	0.4
Hair/balding pattern: Pattern 2	0.5	0.6	3.8	-1.9	0.2	-0.4	-0.6	0.1	-0.1	-0.4
Had menopause	0.3	0.3	1.0	-0.0	-0.5	-0.6	-0.3	0.6	-0.5	1.0
Had other major operations	2.9	3.6	6.2	-0.2	2.4	1.6	-0.8	-2.4	1.9	-2.5
Forced vital capacity (FVC)	0.1	0.4	0.8	0.9	-0.5	-0.6	0.5	0.6	-0.6	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.5	2.5	-0.3	-1.4	-1.5	0.4	1.6	-1.5	0.9
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.5	0.5	1.5	1.8	-2.1	-1.5	1.6	0.2
Qualifications: None of the above	1.2	2.5	5.6	1.3	2.4	1.4	-0.1	-1.8	1.5	-1.6
Financial difficulties in last 2 years	2.3	3.1	7.0	2.6	-0.6	2.4	-2.4	-0.8	0.7	1.4
Mouth/teeth dental problems	0.1	0.2	0.5	0.1	-0.3	-0.1	0.3	0.5	-0.5	0.7
Heart attack	2.8	3.5	6.3	0.9	2.5	1.6	-1.2	-2.3	2.2	-1.9
Allergy	0.3	0.8	2.4	-0.7	0.4	-1.0	1.6	0.1	-0.0	-1.1
Pain all over the body in last month	0.6	0.6	1.9	0.3	-0.8	-0.1	-1.0	0.6	-0.6	1.4
Diabetes (self-reported)	1.1	1.7	5.2	0.0	-1.7	-0.1	-1.3	1.1	-1.0	2.3
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	0.9	0.2	0.9	0.9	-0.5	-0.6	0.7	-0.3
Medication: Ramipril	1.5	2.0	3.0	1.0	1.6	1.3	-1.4	-1.7	1.7	-0.8
Medication: Simvastatin	2.2	3.2	6.5	-1.0	2.5	0.9	0.1	-2.0	2.0	-2.4
Fluid intelligence score	0.1	0.2	0.8	-0.9	-0.1	0.0	-0.4	-0.1	0.3	-0.1
Illnesses of siblings	3.8	5.3	11.8	-2.3	-2.1	-3.4	1.7	2.6	-2.1	1.0
Neuroticism score	0.3	0.7	1.4	0.8	-0.2	0.9	-1.2	-0.5	0.8	0.9
Weight	0.1	0.5	2.4	-0.4	0.3	0.7	-1.5	-0.5	0.2	0.1
Impedance of arm (right)	0.5	2.1	4.4	1.2	1.8	1.1	0.1	-1.7	2.1	-1.3
Arm fat percentage (right)	0.1	0.4	2.5	-1.6	0.0	-0.1	-0.2	0.1	-0.4	-0.1
Trunk fat-free mass	0.2	1.4	2.8	0.7	0.9	1.5	-1.7	-1.3	1.0	-0.7
Hip circumference	0.1	0.3	1.2	-0.4	0.1	0.8	-1.1	-0.2	-0.2	0.2
Time employed in main current job	0.8	0.9	3.4	0.6	0.4	0.9	-1.9	-0.6	0.6	0.8
Alcohol intake versus 10 years previously	0.1	0.1	0.4	0.4	-0.6	-0.4	0.1	0.2	-0.4	-0.1
Father’s age at death	0.3	0.4	0.9	-0.2	-0.4	-0.7	1.0	0.7	-0.9	-0.3
Worrier / anxious feelings	0.5	0.9	3.3	0.2	-0.3	0.6	-1.8	-0.4	0.7	1.3
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.9	9.5	2.5	2.0	3.1	-2.6	-2.7	2.8	-0.2
Falls in the last year	0.4	0.5	1.5	-0.9	-0.6	-0.2	-0.6	0.5	-0.1	1.2
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	0.6	-0.2	0.4	-0.7	-0.3	0.3	0.4
Number of live births	1.4	2.0	4.2	-1.1	2.0	0.9	0.3	-1.4	1.3	-2.0
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.2	0.9	-1.1	-0.9	-0.0	0.8	-0.8	0.8
Pulse rate	0.1	0.2	1.0	1.0	-0.2	0.6	-0.2	-0.0	-0.5	-0.2
Happiness	3.0	3.6	8.4	2.2	0.8	2.9	-2.4	-1.6	1.6	0.7
Noisy workplace	0.3	0.4	1.2	1.1	-0.4	-0.0	0.8	0.6	-0.4	0.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.1	-0.2	0.3	-0.5	1.1	-0.1	0.3	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	0.8	-0.7	0.2	-0.2	0.3	-0.2	0.7
Mouth/teeth dental problems: Dentures	0.8	1.3	4.4	-1.4	0.2	-1.1	2.1	0.5	-0.6	-1.1
Asthma	0.2	0.5	1.2	-0.2	-0.8	0.0	-1.0	0.4	-0.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	2.9	3.6	5.3	1.8	1.9	2.3	-1.7	-2.3	1.9	-1.3
Medication: Cholesterol lowering	0.8	1.3	3.8	-0.3	1.9	0.5	0.1	-1.2	1.2	-1.4
Depression (self-reported)	0.2	0.2	0.4	-0.3	0.3	0.6	-0.1	-0.6	0.6	-0.2
Medication: Lansoprazole	1.5	1.7	3.7	0.0	1.9	1.1	-0.4	-1.6	1.5	-1.4
Prospective memory result	0.8	1.0	2.3	-1.3	-0.5	-1.2	1.5	0.6	-0.9	-0.6
Lung cancer (father)	1.5	1.8	5.4	-0.5	-0.9	-1.0	2.3	1.4	-1.7	0.2
Illnesses of mother	0.2	0.2	0.4	0.4	-0.2	0.5	0.6	0.4	-0.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	0.9	0.3	-0.9	-0.9	-0.4	0.7	-0.5	0.6
Pulse wave Arterial Stiffness index	0.3	0.4	0.9	-1.0	-0.4	-0.1	-0.4	0.6	-0.8	0.7
Impedance of arm (left)	0.5	2.5	5.2	1.9	1.7	1.4	-0.3	-1.8	2.3	-0.8
Arm fat mass (right)	0.1	0.3	1.4	-1.2	0.2	0.3	-0.9	-0.1	-0.3	-0.1
Trunk predicted mass	0.3	1.5	2.7	0.7	1.1	1.6	-1.6	-1.4	1.1	-0.8
Standing height	0.8	7.8	11.4	2.8	3.0	2.9	-1.9	-3.3	3.4	-1.8
Length of working week for main job	0.3	0.4	0.8	0.5	-0.9	-0.4	-0.8	0.5	-0.5	0.5
Exposure to tobacco smoke at home	1.2	1.4	2.4	0.8	1.5	1.2	0.1	-1.3	1.5	-0.9
Breastfed as a baby	1.1	1.3	2.6	0.4	1.6	0.9	-0.6	-1.4	1.1	-1.5
Tense / ‘highly strung’	0.1	0.2	0.4	-0.5	0.6	0.1	0.2	-0.4	0.5	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.9	-1.0	0.4	-0.6	-0.1	-0.0	0.2	-0.3
Hair/balding pattern: Pattern 4	2.4	5.8	10.2	-1.8	-1.9	-3.2	2.5	2.9	-3.0	0.5
Birth weight of first child	0.3	0.5	0.8	-0.9	-0.8	-0.5	-0.5	0.8	-0.8	0.7
Peak expiratory flow (PEF)	0.1	0.2	1.0	1.0	-0.5	-0.0	-0.0	0.1	-0.2	0.2
Pulse wave reflection index	0.5	0.6	2.9	-1.7	-0.4	-0.2	0.3	0.5	-0.6	0.4
Ever highly irritable/argumentative for 2 days	1.1	1.4	4.8	-0.1	-1.0	-0.0	-2.2	0.5	0.0	1.8
Loud music exposure frequency	1.2	1.3	2.4	0.3	1.5	1.3	-0.5	-1.4	1.4	-1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.6	-1.3	0.3	0.4	0.4	-0.6	0.5	-1.2
Mouth/teeth dental problems: Bleeding gums	1.0	1.2	2.5	-0.7	-1.6	-1.4	0.6	1.3	-1.0	0.9
Blood clot in the leg (DVT)	1.0	1.3	5.1	1.4	-0.1	1.0	-2.2	-0.6	0.5	0.8
Medication: Paracetamol	2.7	4.5	11.0	1.0	3.3	1.3	-0.3	-2.4	2.3	-2.5
Headache pain in last month	0.6	1.0	2.6	-1.6	0.6	-0.8	1.0	-0.3	0.3	-1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.1	0.4	-1.8	-0.8	0.0	1.4	-1.4	1.3
Glaucoma (self-reported)	0.6	0.7	1.3	-0.2	-1.2	-0.8	0.0	1.0	-0.8	1.0
Gout (self-reported)	0.1	0.2	0.5	0.3	-0.7	-0.5	0.2	0.5	-0.4	0.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	5.6	2.4	-0.0	1.1	-1.3	-0.3	0.7	0.9
Medication: Amlodipine	0.5	0.7	1.3	1.0	0.9	0.4	-0.1	-1.0	1.1	-0.7
Medication: Ventolin 100micrograms inhaler	0.7	1.0	2.8	0.1	-1.1	0.4	-1.3	0.7	-0.7	1.7
Birth weight	5.7	12.3	22.1	-1.9	-3.8	-3.7	3.1	4.4	-4.7	1.9
Chronic bronchitis/emphysema (mother)	3.2	3.7	6.2	2.4	1.0	2.5	-2.2	-1.8	2.2	0.4
High blood pressure (siblings)	2.4	3.4	6.7	1.2	2.1	2.6	-1.6	-2.2	1.8	-0.7
Forced vital capacity (FVC), Best measure	0.2	0.6	1.0	0.5	-1.0	-1.0	0.2	0.9	-0.9	0.6
Body fat percentage	0.1	0.2	0.8	-0.9	0.4	0.4	-0.6	-0.3	0.0	-0.1
Leg fat percentage (right)	0.1	0.3	0.9	-1.0	0.4	0.4	0.3	-0.2	-0.4	-0.6
Arm fat-free mass (right)	0.2	0.8	4.0	0.4	0.2	0.9	-2.0	-0.6	0.5	0.3
Exposure to tobacco smoke outside home	0.8	1.1	2.4	1.3	0.6	1.5	-1.0	-0.9	1.1	0.4
Comparative body size at age 10	1.3	3.5	6.7	1.0	-2.5	-0.4	0.1	2.1	-2.4	2.6
Number of full brothers	0.6	0.7	1.5	0.5	-0.9	1.1	-1.1	0.1	-0.3	1.2
Worry too long after embarrassment	0.4	0.7	2.3	0.5	-0.9	0.5	-0.9	0.0	0.3	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.5	-0.3	0.6	0.8	-1.1	-0.9	1.2	0.3
Wheeze or whistling in the chest in last year	0.5	0.9	2.1	-0.4	-0.9	-0.6	0.5	1.2	-1.4	0.9
Number of children fathered	2.0	2.3	5.6	-1.2	2.4	0.9	0.4	-1.5	1.5	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	-0.8	0.4	0.8	-0.2	-0.9	0.7	-0.8
Age at first live birth	0.3	0.5	1.9	-0.9	-0.5	-1.4	0.2	0.6	-0.4	0.2
Pulse wave peak to peak time	0.5	0.6	1.8	1.3	0.5	0.4	0.2	-0.7	1.0	-0.7
Health satisfaction	3.8	4.9	8.6	1.6	2.4	2.2	-2.9	-2.4	2.5	-0.6
Shortness of breath walking on level ground	0.7	0.9	2.0	0.4	0.7	1.4	-0.8	-1.2	1.0	-0.5
Qualifications: College or University degree	0.1	0.4	1.4	-0.5	-0.7	-1.2	0.4	0.7	-0.6	0.1
Eye problems/disorders: None of the above	0.5	0.6	1.0	-1.0	-0.5	-0.6	0.9	0.8	-0.9	0.7
Mouth/teeth dental problems: Loose teeth	0.5	0.5	2.2	0.3	0.1	1.0	-1.5	-0.6	0.2	0.2
Emphysema/chronic bronchitis	0.1	0.1	0.2	0.4	0.1	0.1	-0.4	0.1	-0.2	0.4
Medication for pain relief, constipation, heartburn	5.6	9.6	17.3	-1.6	-4.2	-3.1	1.4	3.8	-3.6	2.9
Neck or shoulder pain in last month	0.9	1.3	2.4	0.7	0.8	1.6	-1.2	-1.4	1.5	-0.1
Medication: Blood pressure	1.0	1.7	3.1	0.3	1.7	1.5	-0.2	-1.8	1.6	-1.2
Angina (self-reported)	1.8	2.4	4.5	0.7	1.4	2.1	-1.4	-1.9	1.9	-0.3
Migraine (self-reported)	0.6	0.7	2.8	0.8	-0.0	0.5	-1.7	-0.3	0.8	0.7
Medication: Ibuprofen	3.5	4.1	6.8	2.3	1.3	2.6	-2.5	-2.2	1.9	-0.6
Medication: Allopurinol	0.4	0.6	1.2	0.5	0.8	0.4	-0.5	-0.9	0.9	-1.1
Medication: Omeprazole	1.4	1.6	3.4	-0.4	1.8	0.8	-0.1	-1.6	1.7	-1.3
Medication: Seretide 50 evohaler	5.3	6.1	13.8	-0.1	3.7	1.8	0.4	-2.8	2.3	-3.4
Mean time to correctly identify matches	0.2	0.4	1.0	-0.3	-0.0	-1.0	0.2	0.8	-0.7	0.5
Heart disease (mother)	0.4	0.5	1.5	-0.7	0.4	-0.7	1.2	0.0	-0.2	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.6	-0.2	0.4	-0.4	0.5	-0.0	0.2	-0.8
Whole body fat mass	0.1	0.4	1.4	-0.8	0.3	0.6	-1.2	-0.3	0.0	0.1
Leg fat mass (right)	0.1	0.3	0.7	-0.9	0.3	0.6	-0.7	-0.3	-0.3	-0.1
Arm predicted mass (right)	0.2	0.8	4.4	0.3	0.2	0.8	-2.1	-0.5	0.4	0.4
Pulse rate, automated reading	0.1	0.3	1.8	1.4	0.0	0.4	-0.5	0.2	-0.4	0.0
Alcohol intake frequency.	0.2	0.5	1.0	1.0	-0.6	-0.3	-0.7	0.5	-0.5	1.0
Comparative height size at age 10	1.0	5.6	9.5	2.2	1.9	2.9	-3.1	-2.5	2.7	0.1
Number of full sisters	4.3	5.2	10.4	2.6	1.7	3.2	-2.5	-2.3	2.3	-0.1
Suffer from ‘nerves’	0.2	0.3	0.9	0.7	-0.5	-0.2	0.3	0.4	-0.2	1.0
Overall health rating	8.5	18.2	27.2	3.1	4.5	5.2	-3.5	-5.2	5.1	-2.3
Chest pain or discomfort	0.4	0.5	1.8	0.5	-0.4	1.3	-1.1	-0.3	0.2	0.7
Had major operations	2.0	2.3	5.5	1.3	0.5	2.0	-2.3	-1.4	1.5	0.6
Age at last live birth	0.9	1.3	4.1	-1.8	-0.2	-2.0	0.6	0.8	-0.7	-0.3
Family relationship satisfaction	1.2	1.5	4.2	1.8	0.3	2.0	-1.0	-1.1	1.0	0.1
Leg pain on walking	0.7	0.9	2.3	1.1	0.4	1.2	-1.5	-0.7	0.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.0	-0.5	-1.0	-0.8	0.1	0.7	-0.3	0.6
Commuting to job workplace: Car/motor vehicle	2.4	2.8	7.4	0.1	2.7	1.1	-0.2	-1.9	1.6	-2.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	2.3	-1.5	0.2	-0.7	0.7	0.4	-0.5	-0.6
Medication: Aspirin	1.2	1.6	2.7	0.3	1.4	1.6	-1.1	-1.5	1.4	-0.7
Supplements: Vitamin C	0.9	1.0	2.6	0.7	0.5	1.6	-1.0	-1.3	1.2	-0.1
Knee pain experienced in last month	0.2	0.4	0.7	0.3	0.8	0.7	-0.6	-0.7	0.5	-0.5
Hypertension (Self-reported)	0.4	1.2	2.5	-0.2	1.1	1.5	-0.8	-1.6	1.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	4.4	-2.1	0.3	-1.1	0.7	0.4	-0.2	-0.4
Illnesses of father: Heart disease	1.9	2.7	5.5	0.5	1.5	1.6	-2.0	-1.9	2.4	-0.6
Illnesses of siblings: Diabetes	2.3	2.8	6.5	2.0	-1.6	1.2	-2.2	0.2	-0.2	2.5
Smoking status: Previous	0.9	1.4	5.3	-2.3	-0.4	-1.5	0.4	1.0	-1.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.2	0.5	0.8	0.8	-1.1	-1.1	1.1	-0.5
Whole body fat-free mass	0.1	0.8	3.6	0.4	0.3	1.0	-1.9	-0.7	0.5	0.1
Leg fat-free mass (right)	0.2	1.2	4.3	0.1	-1.0	0.2	-2.1	0.4	-0.4	1.5
Arm fat percentage (left)	0.1	0.3	1.7	-1.3	-0.2	-0.1	-0.5	0.2	-0.5	0.3
Average weekly red wine intake	1.3	1.9	3.0	-1.6	-0.7	-1.7	1.3	1.5	-1.6	0.0
Handedness (chirality/laterality): Left-handed	2.0	2.4	9.5	0.9	0.2	1.7	-3.1	-1.3	1.4	0.5
Mood swings	1.3	2.3	4.8	1.4	0.9	1.9	-2.2	-1.5	1.5	0.2
Loneliness, isolation	4.5	6.2	10.4	1.9	1.7	3.2	-3.2	-2.7	3.0	0.1
Long-standing illness, disability or infirmity	3.7	5.6	8.7	1.6	2.7	3.0	-2.2	-2.8	2.6	-1.2
Ever had bowel cancer screening	0.1	0.2	0.5	0.5	0.0	0.1	0.7	-0.0	-0.3	-0.5
Diabetes diagnosed by doctor	0.9	1.4	4.8	0.3	-1.2	0.0	-1.7	0.7	-0.4	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	4.0	-0.7	1.4	1.3	-0.7	-1.8	2.0	-1.2
Friendships satisfaction	0.6	0.7	1.4	0.7	0.7	0.9	-1.0	-1.0	1.2	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.4	-0.5	0.6	-0.5	0.1	-0.0	0.1	-0.6
Commuting to job workplace: Walk	0.5	0.6	1.4	0.4	-1.0	0.4	-1.1	0.1	-0.0	1.2
Eye problems/disorders: Cataract	0.3	0.4	0.7	-0.4	0.3	0.6	-0.6	-0.7	0.7	-0.8
Mouth/teeth dental problems: Mouth ulcers	3.1	5.0	7.8	1.5	2.6	2.1	-1.7	-2.7	2.8	-1.8
Medication for cholesterol	3.7	5.6	8.8	0.6	-3.0	-2.1	1.9	3.0	-2.8	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.7	0.9	0.7	1.3	-0.3	-0.9	0.7	-0.4
Back pain experienced in last month	1.6	2.3	3.5	1.8	1.2	1.9	-1.5	-1.7	1.5	-0.7
Mineral and other dietary supplements	2.4	3.2	6.5	2.5	-1.8	0.8	-2.3	0.6	-0.5	2.5
Breast cancer (self-reported)	0.7	0.9	2.2	-1.2	1.0	0.2	0.2	-1.0	0.7	-1.5
Asthma (self-reported)	0.2	0.4	1.2	-0.1	-0.6	0.1	-1.1	0.4	-0.4	1.1
Osteoporosis (self-reported)	0.3	0.3	0.9	-0.1	0.1	0.8	-1.0	-0.5	0.5	0.4
Osteoarthritis (self-reported)	1.6	2.0	4.0	-0.1	2.0	1.7	0.1	-1.6	1.4	-1.7
Medication: Aspirin	1.2	1.6	2.6	0.0	1.5	1.6	-1.1	-1.6	1.5	-0.8
Medication: Gliclazide	2.1	2.3	4.1	-2.0	-1.1	-1.8	0.2	1.8	-1.7	1.3
Illnesses of father: None of the above (group 1)	1.7	2.1	4.7	-1.8	-0.7	-2.2	1.6	1.3	-1.4	-0.5
Smoking status: Current	3.2	5.0	12.2	2.9	1.6	3.5	-1.7	-2.4	2.0	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	3.9	-0.0	-2.0	-1.6	0.3	1.4	-1.2	0.9
Whole body water mass	0.1	0.8	3.6	0.5	0.2	1.0	-1.9	-0.7	0.5	0.1
Leg predicted mass (right)	0.2	1.2	4.7	0.1	-1.0	0.2	-2.2	0.4	-0.4	1.5
Arm fat mass (left)	0.1	0.3	1.1	-1.1	-0.0	0.2	-1.0	-0.0	-0.3	0.2
Number of self-reported non-cancer illnesses	3.1	5.4	8.8	0.6	3.0	2.5	-1.7	-2.9	2.9	-1.7
Average weekly champagne plus white wine intake	0.3	0.5	0.9	0.6	-0.2	0.8	-0.9	-0.5	1.0	0.1
Miserableness	0.5	0.8	2.0	0.8	-0.2	1.1	-1.4	-0.7	1.0	0.3
Guilty feelings	1.3	2.0	4.7	1.4	0.3	1.7	-2.2	-1.1	1.5	0.9
Wears glasses or contact lenses	1.9	2.2	3.9	0.1	1.9	1.5	-0.5	-1.9	2.0	-1.5
Ever taken oral contraceptive pill	1.1	1.2	3.7	-0.6	0.9	0.0	1.7	-0.6	0.4	-1.9
Hearing aid user	0.4	0.5	1.2	-0.3	0.7	0.6	0.6	-0.7	1.1	-0.7
Mother’s age at death	0.0	0.1	0.1	0.3	-0.1	-0.4	0.2	0.3	-0.1	0.1
Financial situation satisfaction	4.1	5.1	10.5	3.2	1.1	3.1	-2.6	-2.0	1.8	0.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.2	1.8	-0.8	0.3	-1.5	0.5	-0.2	2.1
Commuting to job workplace: Public transport	0.9	1.1	2.8	-0.9	-1.7	-0.3	-0.2	1.0	-0.9	1.3
Eye problems/disorders: Glaucoma	0.3	0.4	0.7	-0.1	-0.8	-0.5	0.1	0.8	-0.7	0.7
Medication: Blood pressure	0.7	1.3	3.9	0.1	0.8	1.2	-2.0	-1.3	1.2	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.1	1.1	-0.5	0.6	-1.0	0.0	-0.1	0.7
Supplements: Fish oil (including cod liver oil)	1.9	2.5	5.8	-1.4	2.1	-0.2	1.5	-1.2	1.3	-2.4
High cholesterol (Self-reported)	1.1	1.9	5.3	-1.2	2.0	-0.5	1.1	-0.9	0.8	-2.3
Medication: Bendroflumethiazide	0.4	0.6	2.2	-0.6	0.7	-0.2	0.9	-0.4	-0.1	-1.5
Medication: Paracetamol	2.6	4.0	9.2	1.5	3.0	1.3	-0.7	-2.2	2.1	-2.3
Medication: Lisinopril	0.1	0.2	0.8	0.2	-0.0	0.4	-0.9	-0.2	0.2	0.2
Medication: Atorvastatin	0.4	0.5	2.4	-1.6	-0.4	-0.6	-0.3	0.4	-0.4	0.4
Illnesses of father: High blood pressure	1.4	1.7	4.8	1.8	-1.4	0.7	-1.2	0.4	0.0	2.2
Alcohol drinker status: Never	0.5	0.6	2.3	1.5	0.6	0.3	0.3	-0.6	0.8	-0.8
Ever smoked	0.4	0.7	2.7	-0.6	-0.3	0.6	-1.6	0.1	-0.3	1.1
Basal metabolic rate	0.1	0.7	3.2	0.2	0.2	0.9	-1.8	-0.6	0.4	0.1
Leg fat percentage (left)	0.1	0.2	0.8	-0.9	0.1	0.3	0.0	0.0	-0.6	-0.2
Arm fat-free mass (left)	0.2	1.0	3.6	0.1	0.8	1.1	-1.9	-1.0	0.8	-0.4
Number of operations (self-reported)	3.6	5.4	9.0	1.0	2.2	2.8	-2.3	-2.9	3.0	-1.2
Average weekly beer plus cider intake	4.3	6.2	9.7	-2.5	-2.5	-2.8	1.5	2.9	-3.1	1.7
Irritability	0.4	0.7	1.8	0.2	-1.3	0.3	-0.9	0.5	-0.5	1.3
Risk taking	0.6	0.8	2.0	0.5	-1.4	-0.4	-0.1	0.9	-0.9	1.3
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.4	1.0	0.8	1.2	-0.7	-0.9	0.8	-0.5
Fractured/broken bones in last 5 years	1.3	1.7	2.7	1.4	1.6	1.4	0.9	-1.4	0.7	-1.5
Age started oral contraceptive pill	0.6	0.7	1.5	-1.2	0.4	-1.1	1.2	0.3	-0.3	-0.7
Diastolic blood pressure, automated reading	0.2	0.5	1.5	0.6	-1.2	0.5	0.1	0.4	-1.0	0.4
Ever depressed for a whole week	0.4	0.5	2.0	-0.3	0.7	0.4	-1.4	-0.5	0.6	0.4
Unable to work because of sickness or disability	0.8	1.1	1.7	-0.8	-1.3	-1.1	0.6	1.2	-1.3	0.6
Commuting to job workplace: Cycle	2.6	3.2	4.5	-1.9	-2.1	-2.0	0.9	2.1	-2.1	0.9
Myopia	0.2	0.3	1.2	0.1	-1.1	-0.4	-0.3	0.4	-0.3	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.9	2.0	-0.1	-0.9	-1.3	0.8	1.4	-1.0	0.6
Cholesterol lowering medication	3.6	5.2	8.4	-0.4	2.7	2.4	-1.8	-2.9	2.9	-1.9
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.6	-0.9	1.3	0.2	0.4	-0.8	0.9	-1.0
Pain experienced in last month	0.2	0.4	0.6	-0.3	-0.4	-0.8	0.8	0.7	-0.7	-0.1
Supplements: Calcium	0.5	0.5	1.7	-1.0	0.6	-0.2	0.6	-0.2	0.1	-1.3
Basal cell carcinoma (self-reported)	0.5	0.5	1.4	0.8	0.6	0.0	0.7	-0.6	0.7	-1.2
Heart attack/myocardial infarction (self-reported)	2.7	3.5	6.7	0.8	2.6	1.5	-1.2	-2.3	2.2	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	5.3	1.4	-0.1	1.0	-2.3	-0.6	0.5	0.9
Heart disease (siblings)	0.6	0.8	2.3	-0.8	1.2	0.5	0.5	-0.8	0.4	-1.5
Alcohol drinker status: Previous	1.4	1.6	2.6	-1.1	-1.2	-1.5	1.0	1.6	-1.4	0.9
Pack years of smoking	0.7	1.0	1.9	0.6	1.4	1.1	0.2	-1.3	0.7	-1.1
Impedance of whole body	0.8	4.0	7.1	1.9	2.6	1.6	-0.0	-2.3	2.7	-1.7
Leg fat mass (left)	0.1	0.3	0.9	-0.9	0.1	0.4	-0.8	-0.1	-0.4	0.0
Arm predicted mass (left)	0.2	0.9	3.1	0.0	0.7	1.1	-1.8	-1.0	0.6	-0.4