Best TWAS P=1.21e-15 · Best GWAS P=1.25e-25 conditioned to 0.00033
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FAM198A | 0.15 | 0.10 | bslmm | 423 | 0.11 | 7.2e-13 | -9.4 | 8.0 | 1.2e-15 | -0.85 | 0.06 | 0.94 | TRUE |
| 2 | GTEx | Brain Caudate basal ganglia | POMGNT2 | 0.21 | 0.16 | lasso | 5 | 0.16 | 2.3e-05 | 5.7 | 5.7 | 1.3e-08 | -0.30 | 0.37 | 0.06 | FALSE |
| 3 | GTEx | Brain Cortex | POMGNT2 | 0.22 | 0.22 | lasso | 6 | 0.13 | 2.1e-04 | 5.8 | 6.3 | 3.2e-10 | -0.37 | 0.26 | 0.14 | TRUE |
| 4 | GTEx | Brain Nucleus accumbens basal ganglia | POMGNT2 | 0.36 | 0.28 | lasso | 3 | 0.28 | 4.7e-08 | 5.8 | 6.0 | 1.4e-09 | -0.37 | 0.64 | 0.14 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | POMGNT2 | 0.21 | 0.18 | lasso | 4 | 0.18 | 5.9e-22 | 5.8 | 5.7 | 1.2e-08 | -0.34 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Colon Adenocarcinoma | C3orf39 | 0.11 | 0.07 | lasso | 3 | 0.07 | 7.5e-05 | 5.2 | -5.3 | 8.9e-08 | 0.28 | 0.19 | 0.03 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf39 | 0.03 | 0.02 | blup | 50 | 0.03 | 9.7e-05 | 5.5 | -7.0 | 3.3e-12 | 0.44 | 0.73 | 0.03 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C3orf39 | 0.03 | 0.05 | lasso | 2 | 0.04 | 1.9e-05 | 5.4 | -5.7 | 1.4e-08 | 0.36 | 0.77 | 0.04 | FALSE |