Hub : Genes

POMGNT2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Caudate basal ganglia 0.212 0.075 7.3e-04 0.160 NA 0.092 NA 0.161 2.5e-05 NA 1.3e-03 NA 2.3e-05
2 GTEx Brain Cortex 0.221 0.075 7.4e-04 0.219 NA 0.095 NA 0.129 1.0e-06 NA 1.4e-03 NA 2.1e-04
3 GTEx Brain Nucleus accumbens basal ganglia 0.357 0.108 6.3e-04 0.277 NA 0.125 NA 0.276 4.3e-08 NA 3.2e-04 NA 4.7e-08
4 GTEx Cells EBV-transformed lymphocytes 0.176 0.075 7.9e-03 0.020 NA -0.008 NA 0.001 7.2e-02 NA 7.0e-01 NA 3.0e-01
5 GTEx Liver 0.465 0.126 7.6e-03 -0.010 NA 0.003 NA 0.004 7.6e-01 NA 2.6e-01 NA 2.4e-01
6 GTEx Pancreas 0.193 0.073 5.2e-04 0.179 NA 0.207 NA 0.196 4.9e-08 NA 3.8e-09 NA 1.0e-08
7 ROSMAP Brain Pre-frontal Cortex 0.209 0.044 1.7e-13 0.184 0.128 0.169 0.175 0.175 4.7e-23 4.5e-16 3.3e-21 6.1e-22 5.9e-22

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.8 1.3 -1.1 -1.1 -1.1 -0.1 0.2 1.0 -1.1
Bipolar Disorder or Schizophrenia 0.2 0.6 2.5 -0.3 -0.2 -0.5 -1.6 0.9 0.5 -0.2
Depressed Affect (Nagel 2018) 1.7 3.6 5.5 -2.3 -2.3 -2.2 -0.0 1.3 1.9 -2.1
Depression (Nagel 2018) 1.6 2.3 5.1 -1.8 -1.5 -1.1 1.3 2.3 0.9 -1.5
Intelligence (Savage-Jansen 2018) 0.3 1.1 5.6 0.1 -0.2 0.2 1.1 -2.4 -0.6 -0.3
Neuroticism (Nagel 2018) 0.2 0.4 0.8 -0.9 -0.8 -0.6 -0.5 0.6 0.6 -0.4
Schizophrenia (2018) 0.4 0.9 3.9 0.5 0.7 0.3 -2.0 1.0 -0.1 0.6
Schizophrenia vs Biploar Disorder 0.4 0.5 1.6 0.9 0.5 0.6 -1.3 0.7 -0.1 0.3
Worry (Nagel 2018) 0.1 0.1 0.6 0.1 0.2 0.3 -0.1 -0.7 0.1 0.4
Alzheimer’s Disease (in mother) 0.4 0.4 1.0 -1.0 -0.8 -0.7 -0.6 -0.3 0.5 -0.5
Alzheimer’s Disease (in father) 0.8 0.9 1.9 -1.2 -1.2 -0.8 1.4 0.2 0.4 -0.8
Alzheimer’s Disease (including proxy) 0.7 1.1 2.3 -1.5 -1.5 -0.9 0.8 -0.6 0.5 -1.0
Crohns Disease (2017) 0.9 1.9 2.8 1.2 1.6 1.6 -0.6 -1.0 -1.7 1.6
Irritable Bowel Disease (IBD) 1.3 3.1 5.3 1.6 1.8 1.8 0.2 -2.3 -2.0 1.8
Ulcerative Colitis (UC) 1.0 1.9 4.4 1.1 1.4 1.3 0.6 -2.1 -1.5 1.2
Major Depression (MDD) 2.1 2.5 6.5 1.2 1.2 1.3 -1.8 2.5 -1.4 1.3
Reaction Time 1.3 2.4 6.6 1.7 1.4 1.5 -0.2 -2.6 -1.2 1.2
Verbal and Numeric Reasoning (VNR) 0.6 1.4 6.7 -0.7 -0.8 -0.4 1.2 -2.6 -0.5 -0.6
Breast Cancer 0.2 0.5 2.0 0.0 -0.3 -0.2 -1.4 1.0 0.4 -0.2
Ovarian Cancer 0.1 0.1 0.4 0.2 0.1 -0.1 0.6 -0.4 -0.1 -0.2
Prostate Cancer 0.6 0.8 3.6 0.4 0.4 0.6 0.9 -1.9 -0.6 0.5
Age at First Birth 3.9 5.7 8.6 2.8 2.5 2.9 -0.2 -1.4 -2.9 2.6
Bipolar Disorder (2011) 0.5 0.5 0.8 0.4 0.8 0.5 -0.5 0.7 -0.9 0.8
Body Mass Index (BMI) (2010) 0.4 0.6 1.0 -0.8 -1.0 -0.8 0.7 0.9 -0.1 -0.5
Coronary Artery Disease (CAD) 1.0 1.2 4.1 -0.8 -0.9 -1.1 -0.1 2.0 0.8 -0.9
Crohns Disease (2012) 0.5 0.9 3.1 0.2 0.7 0.6 -1.8 0.9 -0.7 0.8
Mean Putamen Volume 1.7 1.9 3.2 -1.4 -1.5 -1.5 1.8 0.5 1.3 -1.4
Fasting Glucose 1.1 1.3 5.2 -0.4 -0.1 -0.3 -1.7 2.3 0.6 -0.2
HbA1C 0.8 0.9 1.5 0.6 1.1 1.1 -0.9 0.3 -1.1 1.2
HDL Cholesterol 1.2 2.0 13.9 -0.1 -0.1 -0.1 0.3 -3.7 0.1 -0.2
LDL Cholesterol 1.8 2.9 4.3 -1.9 -1.9 -1.7 2.1 1.3 1.4 -1.6
Lupus 0.1 0.1 0.3 -0.3 -0.0 0.0 -0.5 -0.5 -0.4 0.3
Neuroticism (2016) 0.9 1.2 3.8 0.5 0.8 0.6 -1.7 1.9 0.1 0.8
Primary Biliary Cirrhosis 0.6 0.9 1.3 0.5 0.9 0.8 -1.1 1.1 -1.0 1.0
Rheumatoid Arthritis 0.8 1.0 2.0 0.9 1.1 1.0 -0.5 -1.4 -1.0 1.0
Schizophrenia (2014) 0.3 0.6 3.0 -0.2 -0.3 -0.3 -1.7 0.4 0.9 -0.3
Triglycerides 1.8 3.0 11.0 -1.6 -1.4 -1.4 0.5 3.3 1.2 -1.2
Type 2 Diabetes (T2D) (2012) 0.7 0.8 1.9 0.4 0.8 0.8 0.3 -0.4 -1.4 1.4
Ulcerative Colitis 0.4 0.6 2.9 -0.6 -0.2 -0.3 1.7 -1.0 0.2 -0.2
Blood Eosinophil Count 0.8 6.5 10.1 -3.2 -2.5 -2.9 0.6 2.3 3.0 -2.5
Blood Platelet Count 0.1 1.2 4.0 -0.4 -1.1 -0.9 -0.1 0.2 2.0 -1.5
Blood Red Count 0.1 0.6 2.1 -0.6 -0.8 -0.6 0.9 -1.4 -0.1 -0.4
Blood White Count 2.7 19.7 27.7 -5.2 -5.0 -5.3 3.4 0.4 4.6 -5.0
Heel T-Score 0.1 0.7 1.2 -0.9 -0.8 -1.1 0.5 0.9 0.7 -1.1
BMI 0.2 1.0 3.2 0.5 1.0 0.8 -0.7 0.4 -1.8 1.1
Height 1.4 26.5 39.6 5.7 6.3 6.0 -1.2 -4.4 -4.8 5.7
Waist Hip Ratio (WHR) 0.8 3.7 16.8 0.0 -0.2 -0.8 -2.0 4.1 1.9 -1.0
Systolic Blood Pressure 0.3 1.3 6.4 0.2 -0.3 -0.6 0.5 -2.5 1.2 -0.9
Smoking Status 1.0 2.4 7.0 -0.9 -1.0 -1.1 -1.8 2.6 1.5 -1.0
Allergy or Eczema 0.1 0.2 0.7 0.2 0.0 0.2 0.8 0.7 0.1 0.0
Cardiovascular Disease 0.8 2.6 4.3 -2.1 -1.9 -2.0 -0.8 0.1 1.6 -1.8
Hypothyroidism (self reported) 0.3 0.6 1.2 0.3 0.7 0.9 -0.4 0.7 -1.1 1.0
Respiratory disease 0.2 0.4 0.7 -0.3 -0.7 -0.7 0.6 0.1 0.7 -0.8
Type 2 Diabetes (T2D) (2018) 0.7 1.2 1.9 0.8 1.1 1.1 -1.3 1.4 -1.2 0.8
Lung FEV1/FVC ratio 0.1 0.5 2.4 -0.1 -0.0 -0.0 1.5 -0.8 -0.8 0.1
Lung FVC 0.3 1.5 5.2 0.8 0.6 1.0 -1.0 -2.3 -1.1 1.0
Neuroticism 0.2 0.5 1.7 -0.4 -0.3 -0.3 -1.3 0.5 0.9 -0.2
Chronotype (morning person) 0.2 0.4 2.1 0.1 -0.1 -0.1 0.4 1.4 0.8 -0.2
Hair Pigment 0.0 0.2 0.8 -0.1 -0.1 -0.4 -0.8 -0.9 -0.0 0.0
Tanning 0.1 0.7 1.9 -0.1 -0.8 -0.5 1.4 -0.1 1.0 -0.9
Hand grip strength (left) 0.3 0.7 1.7 -1.3 -0.9 -0.6 0.4 -1.0 0.8 -0.7
Number of treatments/medications taken 0.5 0.9 2.6 -0.2 -0.3 -0.5 -1.6 1.6 0.5 -0.5
Average weekly spirits intake 1.9 2.4 3.5 -1.6 -1.9 -1.6 1.4 0.7 1.4 -1.8
Sensitivity / hurt feelings 0.5 0.9 2.1 -1.1 -0.9 -0.7 -1.4 1.0 0.7 -0.4
Frequency of depressed mood in last 2 weeks 1.2 1.6 2.9 -1.7 -1.3 -1.2 1.0 1.2 1.1 -1.4
Hearing difficulty/problems: Yes 0.2 0.3 0.7 0.6 0.5 0.4 0.8 -0.4 -0.3 0.3
Relative age of first facial hair 1.8 3.7 5.8 -1.9 -2.4 -2.2 1.4 0.0 2.2 -2.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 1.4 0.7 1.1 1.2 -0.1 0.2 -1.1 1.1
Ever used hormone-replacement therapy (HRT) 1.4 1.8 3.2 -1.3 -1.3 -1.3 0.9 0.9 1.8 -1.6
Ever had hysterectomy (womb removed) 2.3 2.6 3.6 -1.8 -1.9 -1.8 -0.4 1.6 1.6 -1.7
Systolic blood pressure, automated reading 0.3 0.8 3.4 1.2 0.4 0.1 0.2 -1.8 0.5 -0.3
Eye problems/disorders: Diabetes related eye disease 0.1 0.1 0.3 0.5 0.5 0.3 -0.3 -0.2 0.1 0.1
Angina 0.7 0.9 1.4 -1.2 -1.1 -1.1 0.6 -0.8 0.5 -1.2
Medication for hormone replacement therapy 0.7 0.8 1.6 -0.8 -1.0 -1.0 0.8 -0.1 0.7 -1.2
Vitamin and mineral supplements 0.2 0.3 0.9 -0.6 -0.1 -0.2 1.0 -0.8 0.1 -0.2
Supplements: Zinc 0.9 0.9 2.6 0.0 0.4 0.6 1.6 -1.2 -1.0 0.9
Medication: Co-codamol 1.5 1.7 3.3 -0.9 -1.5 -1.6 0.4 -0.2 1.8 -1.6
Medication: Metformin 0.8 1.2 1.7 1.3 1.2 1.2 -0.8 0.6 -1.3 1.0
Diabetes (father) 0.2 0.2 0.7 0.5 0.4 0.4 0.4 0.3 -0.9 0.2
Diabetes (mother) 2.2 2.8 3.7 1.9 1.9 1.8 -1.3 0.5 -1.9 1.8
Severe depression (siblings) 0.4 0.4 1.2 0.5 0.3 0.5 0.2 0.9 -1.1 0.3
Pack years adult smoking proportion 1.3 1.9 2.8 -1.6 -1.2 -1.7 1.5 0.9 1.3 -1.4
Impedance of leg (right) 0.4 1.7 2.8 -0.4 -1.2 -1.4 1.4 -1.1 1.7 -1.5
Leg fat-free mass (left) 0.9 4.6 7.7 1.6 2.8 2.5 -0.7 -1.2 -2.3 2.8
Trunk fat percentage 0.6 2.2 4.1 1.3 2.0 1.5 0.4 -0.7 -1.9 1.9
Hand grip strength (right) 1.4 3.9 7.2 -2.7 -2.2 -2.0 1.1 -1.6 1.9 -1.9
Townsend deprivation index at recruitment 0.8 1.1 4.0 0.7 1.0 0.9 -0.3 2.0 -0.7 1.0
Current tobacco smoking 2.0 3.2 5.2 -1.2 -1.8 -2.1 1.1 1.5 2.2 -2.3
Average weekly fortified wine intake 0.1 0.1 0.3 -0.0 0.1 -0.0 -0.1 0.6 -0.3 0.2
Maternal smoking around birth 0.3 0.4 2.5 0.0 -0.0 -0.0 -0.5 1.6 0.0 -0.1
Fed-up feelings 0.6 1.1 2.2 -1.5 -1.2 -1.2 -0.2 0.2 1.3 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 5.6 -2.0 -1.5 -1.3 0.6 2.4 0.7 -1.2
Relative age voice broke 0.4 0.6 1.0 -0.7 -1.0 -0.6 -0.6 0.7 0.9 -0.7
Taking other prescription medications 0.8 1.2 5.1 -0.7 -0.6 -0.8 -0.9 2.3 0.5 -0.7
Age when periods started (menarche) 0.7 1.7 3.2 -1.2 -1.6 -1.6 0.3 -0.1 1.8 -1.5
Bilateral oophorectomy (both ovaries removed) 2.5 2.9 4.3 -1.8 -1.9 -2.0 1.2 0.0 2.1 -1.9
Heel bone mineral density (BMD) T-score, automated (left) 0.4 1.0 4.8 -0.4 0.3 0.1 2.2 -0.9 -1.0 0.5
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 5.2 -1.4 -1.2 -1.4 -0.7 -0.5 2.3 -1.4
Qualifications: CSEs or equivalent 0.1 0.2 0.4 0.2 0.4 0.2 -0.1 0.3 -0.7 0.5
Serious illness, injury or assault to yourself 0.9 1.1 2.0 -1.1 -1.0 -1.3 1.4 0.4 0.8 -1.2
High blood pressure 0.5 1.5 2.2 -1.3 -1.4 -1.4 -0.6 0.3 1.5 -1.4
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.2 0.9 0.9 1.1 0.2 0.4 -1.0 1.1
Multivitamins +/- minerals 0.3 0.4 0.7 0.9 0.3 0.6 -0.6 0.8 -0.7 0.6
Stomach or abdominal pain in last month 0.4 0.5 1.8 -0.5 -0.4 -0.8 0.4 1.3 0.4 -0.7
Supplements: Glucosamine 2.8 3.7 8.0 -1.2 -2.2 -2.1 0.9 -0.0 2.8 -2.4
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 1.2 1.1 1.1 0.9 -0.4 0.1 -0.6 1.0
Medication: Atenolol 1.0 1.2 1.8 -1.1 -1.0 -1.2 1.4 -0.7 1.1 -1.1
Medication: Levothyroxine sodium 0.8 1.4 4.3 0.8 0.8 0.8 -2.1 1.5 -0.9 0.8
Sitting height 1.8 13.0 20.3 3.3 4.2 4.0 -0.6 -4.5 -3.2 4.0
Chronic bronchitis/emphysema (father) 1.0 1.2 3.1 -1.1 -0.8 -1.0 0.0 1.8 1.1 -1.0
High blood pressure (mother) 0.2 0.3 1.3 0.2 0.6 0.1 -0.5 -1.2 -0.1 0.2
Body mass index (BMI) 0.1 0.3 0.9 -0.4 0.2 0.0 0.2 0.9 -0.7 0.5
Impedance of leg (left) 0.4 1.7 2.7 -0.6 -1.4 -1.5 1.3 -0.8 1.5 -1.6
Leg predicted mass (left) 0.9 4.9 8.2 1.7 2.9 2.6 -0.8 -1.3 -2.4 2.9
Trunk fat mass 0.7 2.8 5.0 1.4 2.2 1.8 0.2 -1.0 -2.0 2.1
Waist circumference 0.1 0.5 2.2 0.1 0.7 0.3 -0.1 1.5 -0.4 0.6
Number of incorrect matches in round 0.0 0.1 0.1 0.3 0.3 0.2 0.1 0.2 0.2 0.3
Past tobacco smoking 1.3 2.4 8.9 1.0 0.7 0.7 2.2 -3.0 -0.8 0.2
Alcohol usually taken with meals 1.6 2.6 5.8 2.4 1.7 1.7 -0.3 -1.8 -1.4 1.3
Nervous feelings 0.1 0.1 0.6 -0.2 -0.0 -0.0 -0.8 0.3 -0.1 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.5 -1.9 -0.8 -0.7 0.3 1.1 0.0 -0.4
Hearing difficulty/problems with background noise 0.6 1.0 3.2 -0.7 -1.0 -0.9 0.3 1.8 1.0 -0.8
Hair/balding pattern: Pattern 2 6.5 8.2 11.0 3.1 3.1 3.2 -2.6 -0.7 -3.3 3.2
Had menopause 0.5 0.6 1.5 -0.1 -0.4 -0.4 1.1 1.2 0.8 -0.7
Had other major operations 1.1 1.3 2.6 -1.6 -1.3 -1.2 0.1 0.9 0.9 -1.3
Forced vital capacity (FVC) 0.9 3.5 5.0 1.9 1.9 2.1 -1.3 -2.2 -1.4 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.7 -0.6 0.2 -0.2 1.3 -0.5 -0.5 0.2
Ever unenthusiastic/disinterested for a whole week 1.6 2.0 2.7 1.5 1.2 1.5 -1.6 1.3 -1.6 1.1
Qualifications: None of the above 0.8 1.7 6.3 -1.0 -1.0 -1.1 -0.3 2.5 1.3 -0.9
Financial difficulties in last 2 years 3.8 5.1 12.0 -3.5 -2.2 -2.4 1.4 1.9 1.8 -2.0
Mouth/teeth dental problems 0.5 0.8 2.1 1.3 0.0 0.1 1.2 -1.5 0.3 -0.5
Heart attack 0.3 0.3 0.6 -0.8 -0.5 -0.8 0.2 0.6 0.5 -0.5
Allergy 0.1 0.2 1.6 0.3 0.2 0.1 -0.1 -1.3 -0.2 -0.0
Pain all over the body in last month 0.3 0.4 1.4 -0.1 -0.3 -0.3 -1.2 0.6 0.7 -0.4
Diabetes (self-reported) 1.3 1.9 2.5 1.4 1.5 1.6 -1.6 0.6 -1.5 1.2
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 1.9 0.1 -0.1 -0.2 1.2 1.4 0.4 -0.5
Medication: Ramipril 0.3 0.3 0.5 -0.6 -0.7 -0.7 -0.2 -0.4 0.7 -0.6
Medication: Simvastatin 1.0 1.4 3.0 0.4 1.1 1.4 -1.0 -0.8 -1.7 1.6
Fluid intelligence score 0.7 1.4 6.6 0.4 0.2 0.5 1.3 -2.6 -1.0 0.0
Illnesses of siblings 0.1 0.2 0.4 -0.3 -0.1 -0.3 0.5 -0.6 -0.5 -0.0
Neuroticism score 0.3 0.7 1.3 -0.9 -0.7 -0.8 -1.1 0.5 1.0 -0.6
Weight 0.5 2.2 3.8 1.0 1.9 1.6 0.0 -1.0 -1.9 2.0
Impedance of arm (right) 1.3 6.0 11.0 2.9 3.3 2.8 -0.4 -1.2 -2.1 2.8
Arm fat percentage (right) 0.6 2.3 4.1 1.2 2.0 1.6 -0.0 0.1 -2.0 2.0
Trunk fat-free mass 0.2 0.9 1.7 0.4 1.0 1.0 0.1 -1.3 -0.9 1.2
Hip circumference 0.6 2.5 5.3 1.1 1.8 1.5 0.7 -1.1 -2.3 1.9
Time employed in main current job 1.6 1.8 3.3 1.8 1.5 1.5 0.0 -1.1 -1.3 1.4
Alcohol intake versus 10 years previously 0.1 0.1 0.6 -0.2 0.1 0.0 0.5 0.8 -0.3 0.2
Father’s age at death 0.6 0.8 1.6 0.9 0.6 1.3 0.3 -1.1 -0.9 0.8
Worrier / anxious feelings 0.2 0.4 0.9 0.5 0.4 0.7 -0.9 -0.8 -0.2 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.9 2.9 -1.3 -0.8 -0.8 -0.2 1.7 0.0 -0.5
Falls in the last year 0.4 0.6 2.7 -0.8 -0.5 -0.6 -0.3 1.6 0.0 -0.4
Hair/balding pattern: Pattern 3 0.7 1.0 2.2 -1.0 -1.1 -1.1 0.3 1.5 0.9 -0.9
Number of live births 0.8 1.1 4.2 -1.1 -1.0 -0.7 0.4 2.1 0.6 -0.5
Forced expiratory volume in 1-second (FEV1) 1.5 5.1 7.0 2.3 2.4 2.6 -1.1 -2.2 -2.3 2.5
Pulse rate 0.1 0.1 0.3 -0.4 -0.1 -0.1 0.5 0.4 -0.1 -0.0
Happiness 0.2 0.3 0.9 -0.2 -0.5 -0.6 -0.1 0.2 0.9 -0.7
Noisy workplace 0.3 0.4 2.0 -0.4 -0.4 -0.2 0.2 1.4 0.5 -0.2
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.3 0.2 0.7 1.0 0.9 -1.8 -1.3 1.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 3.0 -0.1 0.3 0.4 0.9 -1.7 -0.7 0.2
Mouth/teeth dental problems: Dentures 0.7 1.1 1.8 0.5 1.2 1.3 -0.9 1.2 -0.7 1.4
Asthma 0.1 0.3 1.4 -0.1 -0.4 -0.4 0.1 1.2 0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 3.5 0.2 0.2 0.1 -1.3 1.9 -0.1 0.2
Medication: Cholesterol lowering 0.3 0.5 1.1 0.2 0.6 0.7 -1.1 -0.7 -0.8 0.7
Depression (self-reported) 2.1 2.5 11.2 -1.9 -1.0 -1.0 -0.4 3.3 0.5 -0.5
Medication: Lansoprazole 1.0 1.1 1.6 -1.2 -1.1 -1.3 0.3 1.2 0.9 -1.1
Prospective memory result 0.7 0.8 2.2 -0.4 -0.6 -0.6 -0.9 1.5 1.1 -0.9
Lung cancer (father) 0.7 0.8 1.3 -1.0 -0.9 -0.9 1.1 0.7 0.4 -1.0
Illnesses of mother 1.4 1.8 3.5 -1.0 -1.6 -1.3 0.1 0.8 1.9 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.3 7.0 2.1 2.4 2.6 -0.9 -2.4 -2.6 2.6
Pulse wave Arterial Stiffness index 0.4 0.5 0.9 0.7 0.6 0.7 -0.9 0.1 -1.0 0.8
Impedance of arm (left) 1.6 7.2 12.7 3.1 3.6 3.0 -0.9 -1.8 -2.5 3.0
Arm fat mass (right) 0.5 1.9 3.5 1.0 1.8 1.5 -0.3 0.1 -1.9 1.9
Trunk predicted mass 0.1 0.7 1.4 0.3 0.9 0.9 0.1 -1.2 -0.8 1.1
Standing height 1.2 11.6 18.1 3.3 4.0 3.7 -0.7 -4.3 -2.8 3.7
Length of working week for main job 0.3 0.4 0.9 0.2 0.9 0.3 -0.4 0.9 -0.3 0.7
Exposure to tobacco smoke at home 0.3 0.3 1.3 0.2 0.1 -0.1 1.1 -0.8 0.4 -0.1
Breastfed as a baby 0.3 0.4 1.1 -0.6 -0.7 -0.6 1.0 -0.1 0.4 -0.5
Tense / ‘highly strung’ 0.1 0.2 0.6 -0.7 0.0 -0.2 -0.0 0.6 0.3 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 4.5 -1.0 -0.7 -1.0 -0.4 2.1 0.6 -0.9
Hair/balding pattern: Pattern 4 0.2 0.6 1.3 0.3 0.7 0.8 1.1 -0.5 -1.1 0.5
Birth weight of first child 2.5 4.5 6.0 2.4 2.2 2.4 0.7 -2.4 -2.0 2.2
Peak expiratory flow (PEF) 0.0 0.1 0.2 0.2 0.2 0.3 -0.5 -0.1 0.2 0.2
Pulse wave reflection index 0.3 0.3 2.0 0.0 -0.3 -0.2 -0.3 1.4 -0.1 -0.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.6 -0.9 -0.1 0.2 -1.6 1.9 -0.5 0.5
Loud music exposure frequency 1.8 1.9 3.2 -1.2 -1.8 -1.5 -1.1 1.2 0.8 -1.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 3.7 -0.8 -1.1 -0.8 1.9 -1.2 0.8 -1.0
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.0 -1.0 -0.3 -0.2 -0.7 -0.3 -0.1 0.3
Blood clot in the leg (DVT) 1.1 1.4 3.7 -1.5 -0.9 -1.2 0.4 0.3 1.9 -0.9
Medication: Paracetamol 0.2 0.3 0.9 -0.5 -0.3 -0.6 -0.9 0.1 0.7 -0.4
Headache pain in last month 1.2 2.1 4.0 1.1 1.7 1.5 -0.6 0.6 -2.0 1.9
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 0.4 0.4 0.2 0.3 0.2 0.2 0.1
Glaucoma (self-reported) 0.5 0.6 1.6 0.8 0.6 0.7 0.2 1.3 -0.3 0.7
Gout (self-reported) 1.3 1.8 4.7 1.5 1.1 1.3 -2.2 -0.2 -1.0 1.1
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 2.5 0.7 0.9 1.1 -1.6 1.0 -1.0 1.1
Medication: Amlodipine 0.4 0.5 1.0 -0.3 -1.0 -0.6 -0.5 -0.2 1.0 -1.0
Medication: Ventolin 100micrograms inhaler 1.5 1.9 3.1 -1.2 -1.4 -1.6 0.3 1.8 1.3 -1.6
Birth weight 0.5 1.1 4.4 0.4 0.6 0.8 -2.1 0.6 -0.9 0.9
Chronic bronchitis/emphysema (mother) 0.2 0.3 1.4 -0.3 -0.2 0.0 1.2 0.1 -0.6 -0.0
High blood pressure (siblings) 1.1 1.5 3.6 -1.0 -1.4 -1.0 0.0 1.3 1.9 -1.2
Forced vital capacity (FVC), Best measure 1.4 5.1 6.2 2.3 2.4 2.5 -1.2 -2.5 -2.2 2.5
Body fat percentage 0.3 1.2 2.2 0.8 1.5 1.0 0.5 -0.2 -1.5 1.4
Leg fat percentage (right) 0.1 0.3 1.5 -0.5 -0.3 -0.5 1.2 0.4 -0.1 -0.2
Arm fat-free mass (right) 0.1 0.5 1.3 0.1 0.7 0.6 -0.1 -1.1 -0.8 0.9
Exposure to tobacco smoke outside home 0.6 0.8 2.2 -1.0 -0.8 -1.0 0.1 0.7 1.5 -0.7
Comparative body size at age 10 0.3 0.8 3.5 -0.6 -0.6 -0.6 -0.5 1.9 0.5 -0.5
Number of full brothers 1.0 1.3 2.4 -0.5 -1.0 -1.2 -0.2 1.0 1.5 -1.6
Worry too long after embarrassment 0.5 0.8 2.7 0.7 0.6 0.9 0.0 -1.6 -0.9 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.7 0.2 0.4 0.4 -1.1 1.9 -0.0 0.3
Wheeze or whistling in the chest in last year 0.7 1.2 2.2 -1.0 -1.0 -0.9 1.5 1.4 0.6 -1.0
Number of children fathered 0.1 0.2 0.5 0.2 0.2 0.1 0.7 0.7 -0.2 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.3 0.0 0.5 0.8 0.1 -0.3 -1.1 1.0
Age at first live birth 1.0 1.7 9.7 0.9 0.4 0.8 0.2 -3.1 -0.5 0.7
Pulse wave peak to peak time 0.2 0.3 0.9 -0.4 -0.1 -0.3 0.9 -0.4 0.6 -0.4
Health satisfaction 0.6 0.8 1.3 -1.1 -1.0 -1.1 0.2 0.3 1.0 -1.1
Shortness of breath walking on level ground 0.5 0.6 2.2 -0.7 -0.4 -0.4 -1.5 1.2 0.0 -0.3
Qualifications: College or University degree 1.6 5.0 6.8 2.0 2.4 2.3 -1.0 -2.6 -2.5 2.4
Eye problems/disorders: None of the above 0.8 0.9 2.2 -0.7 -0.8 -0.9 1.5 -1.3 0.3 -0.7
Mouth/teeth dental problems: Loose teeth 1.5 1.8 4.1 -1.6 -1.2 -1.5 -0.6 2.0 0.9 -1.2
Emphysema/chronic bronchitis 0.2 0.2 0.4 -0.1 -0.3 -0.5 -0.5 0.3 0.6 -0.6
Medication for pain relief, constipation, heartburn 0.3 0.5 1.8 0.6 0.3 0.5 0.9 -1.3 0.2 0.2
Neck or shoulder pain in last month 0.9 1.2 3.8 -0.2 0.6 0.5 -2.0 1.2 -1.2 1.1
Medication: Blood pressure 0.2 0.4 0.9 -0.9 -0.9 -0.7 0.2 -0.5 0.4 -0.6
Angina (self-reported) 0.7 0.9 1.4 -1.2 -1.0 -1.1 0.7 -0.8 0.5 -1.0
Migraine (self-reported) 0.6 0.7 1.5 -1.2 -1.1 -0.8 0.7 0.6 0.6 -0.7
Medication: Ibuprofen 0.5 0.7 2.6 0.2 0.4 0.3 -1.6 1.2 -0.2 0.5
Medication: Allopurinol 0.4 0.6 1.4 1.0 0.7 0.7 -1.2 0.3 -0.3 0.6
Medication: Omeprazole 1.7 2.0 5.2 -1.4 -1.4 -1.4 0.6 2.3 0.9 -1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.5 0.6 0.5 0.3 -0.4 0.7 -0.2 0.1
Mean time to correctly identify matches 1.6 3.0 9.0 1.7 1.6 1.7 0.4 -3.0 -1.3 1.4
Heart disease (mother) 1.0 1.2 3.1 0.9 1.1 1.2 -0.5 -0.5 -1.8 1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.1 -0.5 -0.9 -0.7 -0.9 1.0 1.0 -0.8
Whole body fat mass 0.5 2.3 4.0 1.3 2.0 1.6 0.1 -0.7 -1.9 2.0
Leg fat mass (right) 0.1 0.4 0.7 0.1 0.7 0.5 0.5 -0.3 -0.8 0.8
Arm predicted mass (right) 0.1 0.4 1.5 0.0 0.6 0.5 -0.2 -1.2 -0.6 0.7
Pulse rate, automated reading 0.8 2.5 7.3 -1.2 -1.4 -1.2 -0.9 2.7 1.7 -1.3
Alcohol intake frequency. 0.8 1.8 3.3 1.8 1.7 1.7 0.3 0.5 -1.1 1.4
Comparative height size at age 10 2.6 14.3 19.0 3.8 4.4 4.1 -2.5 -3.2 -3.8 4.3
Number of full sisters 1.5 1.8 3.0 -1.7 -1.5 -1.4 1.2 0.3 1.6 -1.1
Suffer from ‘nerves’ 0.6 0.9 1.7 -1.1 -1.0 -1.1 0.1 0.2 1.3 -0.9
Overall health rating 1.1 2.3 5.5 -1.1 -1.3 -1.6 -0.6 2.3 1.5 -1.7
Chest pain or discomfort 1.1 1.6 2.6 -1.1 -1.4 -1.6 -0.1 1.4 1.0 -1.6
Had major operations 1.2 1.4 5.7 0.8 0.8 0.9 -2.4 0.7 -0.9 0.8
Age at last live birth 0.8 1.1 3.0 -0.4 -1.0 -0.7 1.4 -1.7 0.8 -0.8
Family relationship satisfaction 0.4 0.5 0.7 0.7 0.7 0.8 -0.8 0.6 0.1 0.7
Leg pain on walking 1.5 1.8 3.8 -1.0 -1.2 -1.3 -0.2 1.4 2.0 -1.6
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.0 0.1 0.2 -0.0 -0.1 0.1 0.1 0.1
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.9 -0.2 -0.2 -0.1 -1.4 -1.1 -0.1 0.3
Illness, injury, bereavement, stress in last 2 years 2.5 3.1 5.3 2.3 1.4 1.7 -2.2 -1.2 -1.6 1.6
Medication: Aspirin 0.5 0.7 2.5 -0.2 0.6 0.6 0.6 -0.5 -1.6 0.9
Supplements: Vitamin C 0.2 0.2 1.1 -0.4 0.1 -0.3 -1.1 0.3 -0.5 0.2
Knee pain experienced in last month 2.2 3.4 4.3 -2.1 -1.8 -1.9 -1.2 1.9 2.0 -1.9
Hypertension (Self-reported) 0.5 1.4 2.3 -1.2 -1.3 -1.3 -0.9 0.1 1.5 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.7 -1.6 -1.2 -1.4 0.4 1.3 -0.0 -1.0
Illnesses of father: Heart disease 0.4 0.6 2.1 -1.4 -1.0 -0.8 0.5 0.0 0.4 -0.3
Illnesses of siblings: Diabetes 2.8 3.5 6.2 1.4 2.1 2.3 -0.4 -0.5 -2.5 2.5
Smoking status: Previous 0.9 1.4 4.6 -0.0 0.4 0.4 -2.1 2.0 -0.2 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 2.8 1.4 1.7 1.3 -0.7 -0.6 -0.8 1.5
Whole body fat-free mass 0.3 1.9 3.3 0.9 1.7 1.6 -0.3 -1.2 -1.5 1.8
Leg fat-free mass (right) 0.9 5.0 8.2 1.7 2.8 2.6 -0.9 -1.2 -2.5 2.9
Arm fat percentage (left) 0.6 2.5 4.5 1.2 2.1 1.6 -0.2 -0.0 -2.1 2.1
Average weekly red wine intake 0.4 0.5 1.1 -0.5 -0.9 -0.8 -0.1 -0.4 1.0 -0.9
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 0.2 -0.1 -0.2 0.0 -0.4 0.5 0.0
Mood swings 1.1 2.0 7.3 -0.9 -1.0 -1.0 -1.2 2.7 1.1 -0.9
Loneliness, isolation 1.1 1.5 2.4 -1.6 -1.5 -1.2 -0.3 -1.1 1.0 -1.4
Long-standing illness, disability or infirmity 0.3 0.5 1.7 -0.6 -0.3 -0.4 0.7 1.3 0.1 -0.5
Ever had bowel cancer screening 0.3 0.4 1.8 -0.1 0.3 0.2 1.3 0.2 -0.7 0.4
Diabetes diagnosed by doctor 0.5 0.8 1.1 1.0 0.9 1.1 -1.1 0.3 -1.0 0.7
Ever had stillbirth, spontaneous miscarriage or termination 1.8 1.9 6.6 -1.2 -1.2 -1.3 0.4 2.6 1.0 -1.0
Friendships satisfaction 0.2 0.3 0.6 0.7 0.3 0.6 0.4 -0.7 -0.4 0.6
Qualifications: nursing, teaching 1.6 2.4 4.5 1.6 1.6 1.8 0.4 -0.9 -2.1 1.8
Commuting to job workplace: Walk 0.3 0.3 1.7 0.2 0.5 0.3 -1.3 -0.2 -0.3 0.4
Eye problems/disorders: Cataract 0.2 0.2 0.7 -0.0 0.2 0.3 -0.8 0.6 0.2 0.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 2.0 -0.3 0.0 -0.1 -1.0 1.4 -0.4 -0.2
Medication for cholesterol 1.4 2.1 3.5 1.4 1.7 1.7 -0.1 -0.7 -1.7 1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 4.0 4.7 7.5 -2.2 -2.5 -2.6 1.2 0.1 2.4 -2.7
Back pain experienced in last month 0.9 1.3 1.9 -1.4 -1.3 -1.4 0.3 1.2 0.9 -1.3
Mineral and other dietary supplements 2.3 3.1 6.8 1.5 2.1 1.9 0.4 -0.9 -2.6 2.0
Breast cancer (self-reported) 0.3 0.3 0.9 -0.4 0.3 0.2 0.9 -0.8 -0.4 0.6
Asthma (self-reported) 0.2 0.4 1.0 -0.3 -0.6 -0.6 0.5 1.0 0.6 -0.6
Osteoporosis (self-reported) 0.9 1.1 3.9 0.8 0.2 0.4 -2.0 1.6 0.3 -0.0
Osteoarthritis (self-reported) 1.5 1.9 3.5 -1.1 -1.5 -1.6 0.7 0.1 1.9 -1.9
Medication: Aspirin 0.3 0.4 1.6 -0.4 0.3 0.3 -0.1 -0.5 -1.3 0.7
Medication: Gliclazide 0.3 0.3 1.1 -0.3 0.1 0.3 0.8 -1.1 -0.2 0.3
Illnesses of father: None of the above (group 1) 0.1 0.2 0.9 0.1 0.2 0.2 0.2 1.0 0.4 -0.1
Smoking status: Current 2.7 4.2 6.5 -1.6 -2.1 -2.4 1.1 1.9 2.4 -2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 4.6 1.2 0.9 1.0 -0.5 -2.1 -0.9 0.8
Whole body water mass 0.3 2.0 3.3 0.9 1.7 1.6 -0.3 -1.3 -1.6 1.8
Leg predicted mass (right) 0.9 4.7 7.9 1.7 2.8 2.6 -0.9 -1.2 -2.5 2.8
Arm fat mass (left) 0.5 2.0 3.8 1.0 1.9 1.5 -0.3 -0.1 -1.9 1.9
Number of self-reported non-cancer illnesses 0.7 1.3 4.5 -1.2 -0.7 -0.8 -1.0 2.1 0.7 -0.7
Average weekly champagne plus white wine intake 0.9 1.2 3.1 0.8 0.8 1.0 -0.1 -1.8 -1.5 1.0
Miserableness 1.1 1.9 3.4 -1.5 -1.2 -1.5 -0.4 1.8 1.5 -1.3
Guilty feelings 0.0 0.1 0.3 -0.2 -0.0 0.1 0.5 -0.3 -0.1 0.2
Wears glasses or contact lenses 0.1 0.2 0.4 -0.2 0.3 0.2 -0.6 0.3 -0.6 0.4
Ever taken oral contraceptive pill 0.9 1.1 1.7 -1.3 -1.1 -1.2 0.7 0.8 0.7 -1.1
Hearing aid user 1.8 2.1 3.8 1.7 1.5 1.5 -2.0 0.3 -1.1 1.3
Mother’s age at death 1.5 1.9 3.1 1.2 1.4 1.5 -0.6 -1.3 -1.5 1.7
Financial situation satisfaction 1.1 1.4 2.9 -1.7 -1.2 -1.1 0.4 -0.2 1.5 -1.1
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.8 -0.5 -0.1 -0.1 1.7 1.3 -0.4 0.1
Commuting to job workplace: Public transport 0.7 0.8 2.2 0.8 1.0 0.8 0.4 0.7 -1.5 0.7
Eye problems/disorders: Glaucoma 1.1 1.3 1.9 1.1 1.3 1.4 -0.8 1.0 -0.8 1.3
Medication: Blood pressure 2.2 4.1 7.2 -1.9 -2.3 -2.2 0.7 1.0 2.7 -2.6
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.7 -0.3 -0.5 -0.5 0.8 0.3 -0.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.8 -1.0 -1.4 -1.3 0.0 0.8 1.7 -1.3
High cholesterol (Self-reported) 0.2 0.3 0.9 -0.6 -0.2 -0.2 -0.9 0.8 -0.2 0.1
Medication: Bendroflumethiazide 0.3 0.4 2.2 0.1 -0.3 -0.1 -0.8 -1.5 0.2 -0.4
Medication: Paracetamol 0.2 0.2 1.3 -0.3 -0.0 -0.3 -1.1 0.1 0.4 -0.1
Medication: Lisinopril 0.3 0.4 1.4 -0.3 -0.6 -0.6 -0.3 1.2 0.6 -0.5
Medication: Atorvastatin 0.8 0.9 1.7 -0.7 -0.9 -1.0 0.0 1.1 1.3 -1.2
Illnesses of father: High blood pressure 0.4 0.5 1.3 0.2 0.3 0.3 -1.1 -0.7 -1.1 0.5
Alcohol drinker status: Never 0.6 0.7 1.3 1.1 1.1 1.1 0.2 -0.0 -0.5 0.9
Ever smoked 0.6 1.0 4.0 -0.1 -0.1 -0.1 -1.7 2.0 0.3 0.1
Basal metabolic rate 0.4 2.2 3.7 1.0 1.9 1.7 -0.3 -1.2 -1.7 1.9
Leg fat percentage (left) 0.1 0.3 0.9 -0.6 -0.4 -0.5 1.0 0.5 -0.2 -0.2
Arm fat-free mass (left) 0.0 0.2 0.7 -0.2 0.2 0.2 0.1 -0.8 -0.3 0.4
Number of operations (self-reported) 0.6 1.0 4.0 -0.6 -0.2 0.1 -2.0 1.4 -0.5 0.1
Average weekly beer plus cider intake 0.3 0.4 1.1 -1.1 -0.5 -0.6 -0.0 0.1 0.8 -0.4
Irritability 0.5 0.9 2.3 -1.3 -0.9 -0.9 -0.4 1.5 0.3 -0.6
Risk taking 0.8 1.2 2.8 -1.1 -1.1 -1.2 0.9 1.7 0.0 -1.1
Ever had prostate specific antigen (PSA) test 0.7 0.8 4.1 0.0 -0.5 -0.3 -0.7 2.0 0.4 -0.8
Fractured/broken bones in last 5 years 0.1 0.2 0.6 -0.0 0.1 0.5 -0.2 0.5 -0.8 0.2
Age started oral contraceptive pill 0.7 0.9 4.9 0.2 0.4 0.5 0.3 -2.2 -0.8 0.5
Diastolic blood pressure, automated reading 0.5 1.5 3.1 -0.5 -1.1 -1.5 0.6 -0.3 1.8 -1.8
Ever depressed for a whole week 2.1 2.6 3.9 1.5 1.6 1.7 -2.0 1.0 -2.0 1.5
Unable to work because of sickness or disability 1.4 1.8 10.2 -0.9 -0.4 -0.9 -0.6 3.2 0.6 -0.4
Commuting to job workplace: Cycle 1.2 1.4 2.4 1.1 1.2 1.6 -1.3 -0.2 -0.9 1.5
Myopia 0.2 0.2 0.9 0.2 0.2 0.1 0.8 -0.9 -0.2 0.2
Vascular/heart problems diagnosed by doctor 0.9 2.5 3.9 1.7 1.8 2.0 0.4 -0.4 -1.8 1.9
Cholesterol lowering medication 0.3 0.4 1.2 -1.1 -0.7 -0.8 -0.0 0.2 0.3 -0.7
Medication: Omeprazole (e.g. Zanprol) 3.0 3.7 5.0 -2.1 -2.0 -2.2 1.1 2.2 1.6 -2.0
Pain experienced in last month 0.8 1.3 6.0 0.0 -0.7 -0.4 2.4 -0.7 1.1 -0.8
Supplements: Calcium 0.5 0.6 2.0 0.5 0.6 0.6 -1.4 0.6 -0.6 0.8
Basal cell carcinoma (self-reported) 0.4 0.4 1.3 0.4 -0.4 -0.3 -1.2 -0.5 0.7 -0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.5 -0.6 -0.3 -0.6 -0.2 0.7 0.4 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.5 -1.2 -0.6 -1.0 0.3 0.3 1.6 -0.7
Heart disease (siblings) 0.3 0.3 2.3 0.1 0.1 0.1 0.3 1.5 0.1 -0.1
Alcohol drinker status: Previous 0.4 0.5 1.7 0.6 -0.0 -0.1 -0.8 1.3 0.8 -0.5
Pack years of smoking 0.9 1.4 2.0 -1.4 -1.0 -1.4 1.3 0.7 0.9 -1.2
Impedance of whole body 0.3 1.5 2.8 1.7 1.5 1.1 0.0 -1.5 -0.7 1.1
Leg fat mass (left) 0.1 0.4 1.0 0.2 0.8 0.5 0.3 -0.2 -1.0 0.9
Arm predicted mass (left) 0.1 0.3 1.3 -0.2 0.3 0.3 0.3 -1.1 -0.6 0.6