Hub : Genes

POMGNT2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Caudate basal ganglia	0.212	0.075	7.3e-04	0.160	NA	0.092	NA	0.161	2.5e-05	NA	1.3e-03	NA	2.3e-05
2	GTEx	Brain Cortex	0.221	0.075	7.4e-04	0.219	NA	0.095	NA	0.129	1.0e-06	NA	1.4e-03	NA	2.1e-04
3	GTEx	Brain Nucleus accumbens basal ganglia	0.357	0.108	6.3e-04	0.277	NA	0.125	NA	0.276	4.3e-08	NA	3.2e-04	NA	4.7e-08
4	GTEx	Cells EBV-transformed lymphocytes	0.176	0.075	7.9e-03	0.020	NA	-0.008	NA	0.001	7.2e-02	NA	7.0e-01	NA	3.0e-01
5	GTEx	Liver	0.465	0.126	7.6e-03	-0.010	NA	0.003	NA	0.004	7.6e-01	NA	2.6e-01	NA	2.4e-01
6	GTEx	Pancreas	0.193	0.073	5.2e-04	0.179	NA	0.207	NA	0.196	4.9e-08	NA	3.8e-09	NA	1.0e-08
7	ROSMAP	Brain Pre-frontal Cortex	0.209	0.044	1.7e-13	0.184	0.128	0.169	0.175	0.175	4.7e-23	4.5e-16	3.3e-21	6.1e-22	5.9e-22

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.8	1.3	-1.1	-1.1	-1.1	-0.1	0.2	1.0	-1.1
Bipolar Disorder or Schizophrenia	0.2	0.6	2.5	-0.3	-0.2	-0.5	-1.6	0.9	0.5	-0.2
Depressed Affect (Nagel 2018)	1.7	3.6	5.5	-2.3	-2.3	-2.2	-0.0	1.3	1.9	-2.1
Depression (Nagel 2018)	1.6	2.3	5.1	-1.8	-1.5	-1.1	1.3	2.3	0.9	-1.5
Intelligence (Savage-Jansen 2018)	0.3	1.1	5.6	0.1	-0.2	0.2	1.1	-2.4	-0.6	-0.3
Neuroticism (Nagel 2018)	0.2	0.4	0.8	-0.9	-0.8	-0.6	-0.5	0.6	0.6	-0.4
Schizophrenia (2018)	0.4	0.9	3.9	0.5	0.7	0.3	-2.0	1.0	-0.1	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	0.9	0.5	0.6	-1.3	0.7	-0.1	0.3
Worry (Nagel 2018)	0.1	0.1	0.6	0.1	0.2	0.3	-0.1	-0.7	0.1	0.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.0	-1.0	-0.8	-0.7	-0.6	-0.3	0.5	-0.5
Alzheimer’s Disease (in father)	0.8	0.9	1.9	-1.2	-1.2	-0.8	1.4	0.2	0.4	-0.8
Alzheimer’s Disease (including proxy)	0.7	1.1	2.3	-1.5	-1.5	-0.9	0.8	-0.6	0.5	-1.0
Crohns Disease (2017)	0.9	1.9	2.8	1.2	1.6	1.6	-0.6	-1.0	-1.7	1.6
Irritable Bowel Disease (IBD)	1.3	3.1	5.3	1.6	1.8	1.8	0.2	-2.3	-2.0	1.8
Ulcerative Colitis (UC)	1.0	1.9	4.4	1.1	1.4	1.3	0.6	-2.1	-1.5	1.2
Major Depression (MDD)	2.1	2.5	6.5	1.2	1.2	1.3	-1.8	2.5	-1.4	1.3
Reaction Time	1.3	2.4	6.6	1.7	1.4	1.5	-0.2	-2.6	-1.2	1.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	6.7	-0.7	-0.8	-0.4	1.2	-2.6	-0.5	-0.6
Breast Cancer	0.2	0.5	2.0	0.0	-0.3	-0.2	-1.4	1.0	0.4	-0.2
Ovarian Cancer	0.1	0.1	0.4	0.2	0.1	-0.1	0.6	-0.4	-0.1	-0.2
Prostate Cancer	0.6	0.8	3.6	0.4	0.4	0.6	0.9	-1.9	-0.6	0.5
Age at First Birth	3.9	5.7	8.6	2.8	2.5	2.9	-0.2	-1.4	-2.9	2.6
Bipolar Disorder (2011)	0.5	0.5	0.8	0.4	0.8	0.5	-0.5	0.7	-0.9	0.8
Body Mass Index (BMI) (2010)	0.4	0.6	1.0	-0.8	-1.0	-0.8	0.7	0.9	-0.1	-0.5
Coronary Artery Disease (CAD)	1.0	1.2	4.1	-0.8	-0.9	-1.1	-0.1	2.0	0.8	-0.9
Crohns Disease (2012)	0.5	0.9	3.1	0.2	0.7	0.6	-1.8	0.9	-0.7	0.8
Mean Putamen Volume	1.7	1.9	3.2	-1.4	-1.5	-1.5	1.8	0.5	1.3	-1.4
Fasting Glucose	1.1	1.3	5.2	-0.4	-0.1	-0.3	-1.7	2.3	0.6	-0.2
HbA1C	0.8	0.9	1.5	0.6	1.1	1.1	-0.9	0.3	-1.1	1.2
HDL Cholesterol	1.2	2.0	13.9	-0.1	-0.1	-0.1	0.3	-3.7	0.1	-0.2
LDL Cholesterol	1.8	2.9	4.3	-1.9	-1.9	-1.7	2.1	1.3	1.4	-1.6
Lupus	0.1	0.1	0.3	-0.3	-0.0	0.0	-0.5	-0.5	-0.4	0.3
Neuroticism (2016)	0.9	1.2	3.8	0.5	0.8	0.6	-1.7	1.9	0.1	0.8
Primary Biliary Cirrhosis	0.6	0.9	1.3	0.5	0.9	0.8	-1.1	1.1	-1.0	1.0
Rheumatoid Arthritis	0.8	1.0	2.0	0.9	1.1	1.0	-0.5	-1.4	-1.0	1.0
Schizophrenia (2014)	0.3	0.6	3.0	-0.2	-0.3	-0.3	-1.7	0.4	0.9	-0.3
Triglycerides	1.8	3.0	11.0	-1.6	-1.4	-1.4	0.5	3.3	1.2	-1.2
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.9	0.4	0.8	0.8	0.3	-0.4	-1.4	1.4
Ulcerative Colitis	0.4	0.6	2.9	-0.6	-0.2	-0.3	1.7	-1.0	0.2	-0.2
Blood Eosinophil Count	0.8	6.5	10.1	-3.2	-2.5	-2.9	0.6	2.3	3.0	-2.5
Blood Platelet Count	0.1	1.2	4.0	-0.4	-1.1	-0.9	-0.1	0.2	2.0	-1.5
Blood Red Count	0.1	0.6	2.1	-0.6	-0.8	-0.6	0.9	-1.4	-0.1	-0.4
Blood White Count	2.7	19.7	27.7	-5.2	-5.0	-5.3	3.4	0.4	4.6	-5.0
Heel T-Score	0.1	0.7	1.2	-0.9	-0.8	-1.1	0.5	0.9	0.7	-1.1
BMI	0.2	1.0	3.2	0.5	1.0	0.8	-0.7	0.4	-1.8	1.1
Height	1.4	26.5	39.6	5.7	6.3	6.0	-1.2	-4.4	-4.8	5.7
Waist Hip Ratio (WHR)	0.8	3.7	16.8	0.0	-0.2	-0.8	-2.0	4.1	1.9	-1.0
Systolic Blood Pressure	0.3	1.3	6.4	0.2	-0.3	-0.6	0.5	-2.5	1.2	-0.9
Smoking Status	1.0	2.4	7.0	-0.9	-1.0	-1.1	-1.8	2.6	1.5	-1.0
Allergy or Eczema	0.1	0.2	0.7	0.2	0.0	0.2	0.8	0.7	0.1	0.0
Cardiovascular Disease	0.8	2.6	4.3	-2.1	-1.9	-2.0	-0.8	0.1	1.6	-1.8
Hypothyroidism (self reported)	0.3	0.6	1.2	0.3	0.7	0.9	-0.4	0.7	-1.1	1.0
Respiratory disease	0.2	0.4	0.7	-0.3	-0.7	-0.7	0.6	0.1	0.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.2	1.9	0.8	1.1	1.1	-1.3	1.4	-1.2	0.8
Lung FEV1/FVC ratio	0.1	0.5	2.4	-0.1	-0.0	-0.0	1.5	-0.8	-0.8	0.1
Lung FVC	0.3	1.5	5.2	0.8	0.6	1.0	-1.0	-2.3	-1.1	1.0
Neuroticism	0.2	0.5	1.7	-0.4	-0.3	-0.3	-1.3	0.5	0.9	-0.2
Chronotype (morning person)	0.2	0.4	2.1	0.1	-0.1	-0.1	0.4	1.4	0.8	-0.2
Hair Pigment	0.0	0.2	0.8	-0.1	-0.1	-0.4	-0.8	-0.9	-0.0	0.0
Tanning	0.1	0.7	1.9	-0.1	-0.8	-0.5	1.4	-0.1	1.0	-0.9
Hand grip strength (left)	0.3	0.7	1.7	-1.3	-0.9	-0.6	0.4	-1.0	0.8	-0.7
Number of treatments/medications taken	0.5	0.9	2.6	-0.2	-0.3	-0.5	-1.6	1.6	0.5	-0.5
Average weekly spirits intake	1.9	2.4	3.5	-1.6	-1.9	-1.6	1.4	0.7	1.4	-1.8
Sensitivity / hurt feelings	0.5	0.9	2.1	-1.1	-0.9	-0.7	-1.4	1.0	0.7	-0.4
Frequency of depressed mood in last 2 weeks	1.2	1.6	2.9	-1.7	-1.3	-1.2	1.0	1.2	1.1	-1.4
Hearing difficulty/problems: Yes	0.2	0.3	0.7	0.6	0.5	0.4	0.8	-0.4	-0.3	0.3
Relative age of first facial hair	1.8	3.7	5.8	-1.9	-2.4	-2.2	1.4	0.0	2.2	-2.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.4	0.7	1.1	1.2	-0.1	0.2	-1.1	1.1
Ever used hormone-replacement therapy (HRT)	1.4	1.8	3.2	-1.3	-1.3	-1.3	0.9	0.9	1.8	-1.6
Ever had hysterectomy (womb removed)	2.3	2.6	3.6	-1.8	-1.9	-1.8	-0.4	1.6	1.6	-1.7
Systolic blood pressure, automated reading	0.3	0.8	3.4	1.2	0.4	0.1	0.2	-1.8	0.5	-0.3
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.3	0.5	0.5	0.3	-0.3	-0.2	0.1	0.1
Angina	0.7	0.9	1.4	-1.2	-1.1	-1.1	0.6	-0.8	0.5	-1.2
Medication for hormone replacement therapy	0.7	0.8	1.6	-0.8	-1.0	-1.0	0.8	-0.1	0.7	-1.2
Vitamin and mineral supplements	0.2	0.3	0.9	-0.6	-0.1	-0.2	1.0	-0.8	0.1	-0.2
Supplements: Zinc	0.9	0.9	2.6	0.0	0.4	0.6	1.6	-1.2	-1.0	0.9
Medication: Co-codamol	1.5	1.7	3.3	-0.9	-1.5	-1.6	0.4	-0.2	1.8	-1.6
Medication: Metformin	0.8	1.2	1.7	1.3	1.2	1.2	-0.8	0.6	-1.3	1.0
Diabetes (father)	0.2	0.2	0.7	0.5	0.4	0.4	0.4	0.3	-0.9	0.2
Diabetes (mother)	2.2	2.8	3.7	1.9	1.9	1.8	-1.3	0.5	-1.9	1.8
Severe depression (siblings)	0.4	0.4	1.2	0.5	0.3	0.5	0.2	0.9	-1.1	0.3
Pack years adult smoking proportion	1.3	1.9	2.8	-1.6	-1.2	-1.7	1.5	0.9	1.3	-1.4
Impedance of leg (right)	0.4	1.7	2.8	-0.4	-1.2	-1.4	1.4	-1.1	1.7	-1.5
Leg fat-free mass (left)	0.9	4.6	7.7	1.6	2.8	2.5	-0.7	-1.2	-2.3	2.8
Trunk fat percentage	0.6	2.2	4.1	1.3	2.0	1.5	0.4	-0.7	-1.9	1.9
Hand grip strength (right)	1.4	3.9	7.2	-2.7	-2.2	-2.0	1.1	-1.6	1.9	-1.9
Townsend deprivation index at recruitment	0.8	1.1	4.0	0.7	1.0	0.9	-0.3	2.0	-0.7	1.0
Current tobacco smoking	2.0	3.2	5.2	-1.2	-1.8	-2.1	1.1	1.5	2.2	-2.3
Average weekly fortified wine intake	0.1	0.1	0.3	-0.0	0.1	-0.0	-0.1	0.6	-0.3	0.2
Maternal smoking around birth	0.3	0.4	2.5	0.0	-0.0	-0.0	-0.5	1.6	0.0	-0.1
Fed-up feelings	0.6	1.1	2.2	-1.5	-1.2	-1.2	-0.2	0.2	1.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	5.6	-2.0	-1.5	-1.3	0.6	2.4	0.7	-1.2
Relative age voice broke	0.4	0.6	1.0	-0.7	-1.0	-0.6	-0.6	0.7	0.9	-0.7
Taking other prescription medications	0.8	1.2	5.1	-0.7	-0.6	-0.8	-0.9	2.3	0.5	-0.7
Age when periods started (menarche)	0.7	1.7	3.2	-1.2	-1.6	-1.6	0.3	-0.1	1.8	-1.5
Bilateral oophorectomy (both ovaries removed)	2.5	2.9	4.3	-1.8	-1.9	-2.0	1.2	0.0	2.1	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	4.8	-0.4	0.3	0.1	2.2	-0.9	-1.0	0.5
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	5.2	-1.4	-1.2	-1.4	-0.7	-0.5	2.3	-1.4
Qualifications: CSEs or equivalent	0.1	0.2	0.4	0.2	0.4	0.2	-0.1	0.3	-0.7	0.5
Serious illness, injury or assault to yourself	0.9	1.1	2.0	-1.1	-1.0	-1.3	1.4	0.4	0.8	-1.2
High blood pressure	0.5	1.5	2.2	-1.3	-1.4	-1.4	-0.6	0.3	1.5	-1.4
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.2	0.9	0.9	1.1	0.2	0.4	-1.0	1.1
Multivitamins +/- minerals	0.3	0.4	0.7	0.9	0.3	0.6	-0.6	0.8	-0.7	0.6
Stomach or abdominal pain in last month	0.4	0.5	1.8	-0.5	-0.4	-0.8	0.4	1.3	0.4	-0.7
Supplements: Glucosamine	2.8	3.7	8.0	-1.2	-2.2	-2.1	0.9	-0.0	2.8	-2.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	1.1	1.1	0.9	-0.4	0.1	-0.6	1.0
Medication: Atenolol	1.0	1.2	1.8	-1.1	-1.0	-1.2	1.4	-0.7	1.1	-1.1
Medication: Levothyroxine sodium	0.8	1.4	4.3	0.8	0.8	0.8	-2.1	1.5	-0.9	0.8
Sitting height	1.8	13.0	20.3	3.3	4.2	4.0	-0.6	-4.5	-3.2	4.0
Chronic bronchitis/emphysema (father)	1.0	1.2	3.1	-1.1	-0.8	-1.0	0.0	1.8	1.1	-1.0
High blood pressure (mother)	0.2	0.3	1.3	0.2	0.6	0.1	-0.5	-1.2	-0.1	0.2
Body mass index (BMI)	0.1	0.3	0.9	-0.4	0.2	0.0	0.2	0.9	-0.7	0.5
Impedance of leg (left)	0.4	1.7	2.7	-0.6	-1.4	-1.5	1.3	-0.8	1.5	-1.6
Leg predicted mass (left)	0.9	4.9	8.2	1.7	2.9	2.6	-0.8	-1.3	-2.4	2.9
Trunk fat mass	0.7	2.8	5.0	1.4	2.2	1.8	0.2	-1.0	-2.0	2.1
Waist circumference	0.1	0.5	2.2	0.1	0.7	0.3	-0.1	1.5	-0.4	0.6
Number of incorrect matches in round	0.0	0.1	0.1	0.3	0.3	0.2	0.1	0.2	0.2	0.3
Past tobacco smoking	1.3	2.4	8.9	1.0	0.7	0.7	2.2	-3.0	-0.8	0.2
Alcohol usually taken with meals	1.6	2.6	5.8	2.4	1.7	1.7	-0.3	-1.8	-1.4	1.3
Nervous feelings	0.1	0.1	0.6	-0.2	-0.0	-0.0	-0.8	0.3	-0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.5	-1.9	-0.8	-0.7	0.3	1.1	0.0	-0.4
Hearing difficulty/problems with background noise	0.6	1.0	3.2	-0.7	-1.0	-0.9	0.3	1.8	1.0	-0.8
Hair/balding pattern: Pattern 2	6.5	8.2	11.0	3.1	3.1	3.2	-2.6	-0.7	-3.3	3.2
Had menopause	0.5	0.6	1.5	-0.1	-0.4	-0.4	1.1	1.2	0.8	-0.7
Had other major operations	1.1	1.3	2.6	-1.6	-1.3	-1.2	0.1	0.9	0.9	-1.3
Forced vital capacity (FVC)	0.9	3.5	5.0	1.9	1.9	2.1	-1.3	-2.2	-1.4	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.7	-0.6	0.2	-0.2	1.3	-0.5	-0.5	0.2
Ever unenthusiastic/disinterested for a whole week	1.6	2.0	2.7	1.5	1.2	1.5	-1.6	1.3	-1.6	1.1
Qualifications: None of the above	0.8	1.7	6.3	-1.0	-1.0	-1.1	-0.3	2.5	1.3	-0.9
Financial difficulties in last 2 years	3.8	5.1	12.0	-3.5	-2.2	-2.4	1.4	1.9	1.8	-2.0
Mouth/teeth dental problems	0.5	0.8	2.1	1.3	0.0	0.1	1.2	-1.5	0.3	-0.5
Heart attack	0.3	0.3	0.6	-0.8	-0.5	-0.8	0.2	0.6	0.5	-0.5
Allergy	0.1	0.2	1.6	0.3	0.2	0.1	-0.1	-1.3	-0.2	-0.0
Pain all over the body in last month	0.3	0.4	1.4	-0.1	-0.3	-0.3	-1.2	0.6	0.7	-0.4
Diabetes (self-reported)	1.3	1.9	2.5	1.4	1.5	1.6	-1.6	0.6	-1.5	1.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.9	0.1	-0.1	-0.2	1.2	1.4	0.4	-0.5
Medication: Ramipril	0.3	0.3	0.5	-0.6	-0.7	-0.7	-0.2	-0.4	0.7	-0.6
Medication: Simvastatin	1.0	1.4	3.0	0.4	1.1	1.4	-1.0	-0.8	-1.7	1.6
Fluid intelligence score	0.7	1.4	6.6	0.4	0.2	0.5	1.3	-2.6	-1.0	0.0
Illnesses of siblings	0.1	0.2	0.4	-0.3	-0.1	-0.3	0.5	-0.6	-0.5	-0.0
Neuroticism score	0.3	0.7	1.3	-0.9	-0.7	-0.8	-1.1	0.5	1.0	-0.6
Weight	0.5	2.2	3.8	1.0	1.9	1.6	0.0	-1.0	-1.9	2.0
Impedance of arm (right)	1.3	6.0	11.0	2.9	3.3	2.8	-0.4	-1.2	-2.1	2.8
Arm fat percentage (right)	0.6	2.3	4.1	1.2	2.0	1.6	-0.0	0.1	-2.0	2.0
Trunk fat-free mass	0.2	0.9	1.7	0.4	1.0	1.0	0.1	-1.3	-0.9	1.2
Hip circumference	0.6	2.5	5.3	1.1	1.8	1.5	0.7	-1.1	-2.3	1.9
Time employed in main current job	1.6	1.8	3.3	1.8	1.5	1.5	0.0	-1.1	-1.3	1.4
Alcohol intake versus 10 years previously	0.1	0.1	0.6	-0.2	0.1	0.0	0.5	0.8	-0.3	0.2
Father’s age at death	0.6	0.8	1.6	0.9	0.6	1.3	0.3	-1.1	-0.9	0.8
Worrier / anxious feelings	0.2	0.4	0.9	0.5	0.4	0.7	-0.9	-0.8	-0.2	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.9	-1.3	-0.8	-0.8	-0.2	1.7	0.0	-0.5
Falls in the last year	0.4	0.6	2.7	-0.8	-0.5	-0.6	-0.3	1.6	0.0	-0.4
Hair/balding pattern: Pattern 3	0.7	1.0	2.2	-1.0	-1.1	-1.1	0.3	1.5	0.9	-0.9
Number of live births	0.8	1.1	4.2	-1.1	-1.0	-0.7	0.4	2.1	0.6	-0.5
Forced expiratory volume in 1-second (FEV1)	1.5	5.1	7.0	2.3	2.4	2.6	-1.1	-2.2	-2.3	2.5
Pulse rate	0.1	0.1	0.3	-0.4	-0.1	-0.1	0.5	0.4	-0.1	-0.0
Happiness	0.2	0.3	0.9	-0.2	-0.5	-0.6	-0.1	0.2	0.9	-0.7
Noisy workplace	0.3	0.4	2.0	-0.4	-0.4	-0.2	0.2	1.4	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.3	0.2	0.7	1.0	0.9	-1.8	-1.3	1.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	3.0	-0.1	0.3	0.4	0.9	-1.7	-0.7	0.2
Mouth/teeth dental problems: Dentures	0.7	1.1	1.8	0.5	1.2	1.3	-0.9	1.2	-0.7	1.4
Asthma	0.1	0.3	1.4	-0.1	-0.4	-0.4	0.1	1.2	0.3	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.5	0.2	0.2	0.1	-1.3	1.9	-0.1	0.2
Medication: Cholesterol lowering	0.3	0.5	1.1	0.2	0.6	0.7	-1.1	-0.7	-0.8	0.7
Depression (self-reported)	2.1	2.5	11.2	-1.9	-1.0	-1.0	-0.4	3.3	0.5	-0.5
Medication: Lansoprazole	1.0	1.1	1.6	-1.2	-1.1	-1.3	0.3	1.2	0.9	-1.1
Prospective memory result	0.7	0.8	2.2	-0.4	-0.6	-0.6	-0.9	1.5	1.1	-0.9
Lung cancer (father)	0.7	0.8	1.3	-1.0	-0.9	-0.9	1.1	0.7	0.4	-1.0
Illnesses of mother	1.4	1.8	3.5	-1.0	-1.6	-1.3	0.1	0.8	1.9	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	7.0	2.1	2.4	2.6	-0.9	-2.4	-2.6	2.6
Pulse wave Arterial Stiffness index	0.4	0.5	0.9	0.7	0.6	0.7	-0.9	0.1	-1.0	0.8
Impedance of arm (left)	1.6	7.2	12.7	3.1	3.6	3.0	-0.9	-1.8	-2.5	3.0
Arm fat mass (right)	0.5	1.9	3.5	1.0	1.8	1.5	-0.3	0.1	-1.9	1.9
Trunk predicted mass	0.1	0.7	1.4	0.3	0.9	0.9	0.1	-1.2	-0.8	1.1
Standing height	1.2	11.6	18.1	3.3	4.0	3.7	-0.7	-4.3	-2.8	3.7
Length of working week for main job	0.3	0.4	0.9	0.2	0.9	0.3	-0.4	0.9	-0.3	0.7
Exposure to tobacco smoke at home	0.3	0.3	1.3	0.2	0.1	-0.1	1.1	-0.8	0.4	-0.1
Breastfed as a baby	0.3	0.4	1.1	-0.6	-0.7	-0.6	1.0	-0.1	0.4	-0.5
Tense / ‘highly strung’	0.1	0.2	0.6	-0.7	0.0	-0.2	-0.0	0.6	0.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	4.5	-1.0	-0.7	-1.0	-0.4	2.1	0.6	-0.9
Hair/balding pattern: Pattern 4	0.2	0.6	1.3	0.3	0.7	0.8	1.1	-0.5	-1.1	0.5
Birth weight of first child	2.5	4.5	6.0	2.4	2.2	2.4	0.7	-2.4	-2.0	2.2
Peak expiratory flow (PEF)	0.0	0.1	0.2	0.2	0.2	0.3	-0.5	-0.1	0.2	0.2
Pulse wave reflection index	0.3	0.3	2.0	0.0	-0.3	-0.2	-0.3	1.4	-0.1	-0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.6	-0.9	-0.1	0.2	-1.6	1.9	-0.5	0.5
Loud music exposure frequency	1.8	1.9	3.2	-1.2	-1.8	-1.5	-1.1	1.2	0.8	-1.8
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.7	-0.8	-1.1	-0.8	1.9	-1.2	0.8	-1.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.0	-1.0	-0.3	-0.2	-0.7	-0.3	-0.1	0.3
Blood clot in the leg (DVT)	1.1	1.4	3.7	-1.5	-0.9	-1.2	0.4	0.3	1.9	-0.9
Medication: Paracetamol	0.2	0.3	0.9	-0.5	-0.3	-0.6	-0.9	0.1	0.7	-0.4
Headache pain in last month	1.2	2.1	4.0	1.1	1.7	1.5	-0.6	0.6	-2.0	1.9
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.2	0.4	0.4	0.2	0.3	0.2	0.2	0.1
Glaucoma (self-reported)	0.5	0.6	1.6	0.8	0.6	0.7	0.2	1.3	-0.3	0.7
Gout (self-reported)	1.3	1.8	4.7	1.5	1.1	1.3	-2.2	-0.2	-1.0	1.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.2	2.5	0.7	0.9	1.1	-1.6	1.0	-1.0	1.1
Medication: Amlodipine	0.4	0.5	1.0	-0.3	-1.0	-0.6	-0.5	-0.2	1.0	-1.0
Medication: Ventolin 100micrograms inhaler	1.5	1.9	3.1	-1.2	-1.4	-1.6	0.3	1.8	1.3	-1.6
Birth weight	0.5	1.1	4.4	0.4	0.6	0.8	-2.1	0.6	-0.9	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.4	-0.3	-0.2	0.0	1.2	0.1	-0.6	-0.0
High blood pressure (siblings)	1.1	1.5	3.6	-1.0	-1.4	-1.0	0.0	1.3	1.9	-1.2
Forced vital capacity (FVC), Best measure	1.4	5.1	6.2	2.3	2.4	2.5	-1.2	-2.5	-2.2	2.5
Body fat percentage	0.3	1.2	2.2	0.8	1.5	1.0	0.5	-0.2	-1.5	1.4
Leg fat percentage (right)	0.1	0.3	1.5	-0.5	-0.3	-0.5	1.2	0.4	-0.1	-0.2
Arm fat-free mass (right)	0.1	0.5	1.3	0.1	0.7	0.6	-0.1	-1.1	-0.8	0.9
Exposure to tobacco smoke outside home	0.6	0.8	2.2	-1.0	-0.8	-1.0	0.1	0.7	1.5	-0.7
Comparative body size at age 10	0.3	0.8	3.5	-0.6	-0.6	-0.6	-0.5	1.9	0.5	-0.5
Number of full brothers	1.0	1.3	2.4	-0.5	-1.0	-1.2	-0.2	1.0	1.5	-1.6
Worry too long after embarrassment	0.5	0.8	2.7	0.7	0.6	0.9	0.0	-1.6	-0.9	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	3.7	0.2	0.4	0.4	-1.1	1.9	-0.0	0.3
Wheeze or whistling in the chest in last year	0.7	1.2	2.2	-1.0	-1.0	-0.9	1.5	1.4	0.6	-1.0
Number of children fathered	0.1	0.2	0.5	0.2	0.2	0.1	0.7	0.7	-0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.3	0.0	0.5	0.8	0.1	-0.3	-1.1	1.0
Age at first live birth	1.0	1.7	9.7	0.9	0.4	0.8	0.2	-3.1	-0.5	0.7
Pulse wave peak to peak time	0.2	0.3	0.9	-0.4	-0.1	-0.3	0.9	-0.4	0.6	-0.4
Health satisfaction	0.6	0.8	1.3	-1.1	-1.0	-1.1	0.2	0.3	1.0	-1.1
Shortness of breath walking on level ground	0.5	0.6	2.2	-0.7	-0.4	-0.4	-1.5	1.2	0.0	-0.3
Qualifications: College or University degree	1.6	5.0	6.8	2.0	2.4	2.3	-1.0	-2.6	-2.5	2.4
Eye problems/disorders: None of the above	0.8	0.9	2.2	-0.7	-0.8	-0.9	1.5	-1.3	0.3	-0.7
Mouth/teeth dental problems: Loose teeth	1.5	1.8	4.1	-1.6	-1.2	-1.5	-0.6	2.0	0.9	-1.2
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.1	-0.3	-0.5	-0.5	0.3	0.6	-0.6
Medication for pain relief, constipation, heartburn	0.3	0.5	1.8	0.6	0.3	0.5	0.9	-1.3	0.2	0.2
Neck or shoulder pain in last month	0.9	1.2	3.8	-0.2	0.6	0.5	-2.0	1.2	-1.2	1.1
Medication: Blood pressure	0.2	0.4	0.9	-0.9	-0.9	-0.7	0.2	-0.5	0.4	-0.6
Angina (self-reported)	0.7	0.9	1.4	-1.2	-1.0	-1.1	0.7	-0.8	0.5	-1.0
Migraine (self-reported)	0.6	0.7	1.5	-1.2	-1.1	-0.8	0.7	0.6	0.6	-0.7
Medication: Ibuprofen	0.5	0.7	2.6	0.2	0.4	0.3	-1.6	1.2	-0.2	0.5
Medication: Allopurinol	0.4	0.6	1.4	1.0	0.7	0.7	-1.2	0.3	-0.3	0.6
Medication: Omeprazole	1.7	2.0	5.2	-1.4	-1.4	-1.4	0.6	2.3	0.9	-1.3
Medication: Seretide 50 evohaler	0.2	0.2	0.5	0.6	0.5	0.3	-0.4	0.7	-0.2	0.1
Mean time to correctly identify matches	1.6	3.0	9.0	1.7	1.6	1.7	0.4	-3.0	-1.3	1.4
Heart disease (mother)	1.0	1.2	3.1	0.9	1.1	1.2	-0.5	-0.5	-1.8	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.1	-0.5	-0.9	-0.7	-0.9	1.0	1.0	-0.8
Whole body fat mass	0.5	2.3	4.0	1.3	2.0	1.6	0.1	-0.7	-1.9	2.0
Leg fat mass (right)	0.1	0.4	0.7	0.1	0.7	0.5	0.5	-0.3	-0.8	0.8
Arm predicted mass (right)	0.1	0.4	1.5	0.0	0.6	0.5	-0.2	-1.2	-0.6	0.7
Pulse rate, automated reading	0.8	2.5	7.3	-1.2	-1.4	-1.2	-0.9	2.7	1.7	-1.3
Alcohol intake frequency.	0.8	1.8	3.3	1.8	1.7	1.7	0.3	0.5	-1.1	1.4
Comparative height size at age 10	2.6	14.3	19.0	3.8	4.4	4.1	-2.5	-3.2	-3.8	4.3
Number of full sisters	1.5	1.8	3.0	-1.7	-1.5	-1.4	1.2	0.3	1.6	-1.1
Suffer from ‘nerves’	0.6	0.9	1.7	-1.1	-1.0	-1.1	0.1	0.2	1.3	-0.9
Overall health rating	1.1	2.3	5.5	-1.1	-1.3	-1.6	-0.6	2.3	1.5	-1.7
Chest pain or discomfort	1.1	1.6	2.6	-1.1	-1.4	-1.6	-0.1	1.4	1.0	-1.6
Had major operations	1.2	1.4	5.7	0.8	0.8	0.9	-2.4	0.7	-0.9	0.8
Age at last live birth	0.8	1.1	3.0	-0.4	-1.0	-0.7	1.4	-1.7	0.8	-0.8
Family relationship satisfaction	0.4	0.5	0.7	0.7	0.7	0.8	-0.8	0.6	0.1	0.7
Leg pain on walking	1.5	1.8	3.8	-1.0	-1.2	-1.3	-0.2	1.4	2.0	-1.6
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.0	0.1	0.2	-0.0	-0.1	0.1	0.1	0.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.9	-0.2	-0.2	-0.1	-1.4	-1.1	-0.1	0.3
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	5.3	2.3	1.4	1.7	-2.2	-1.2	-1.6	1.6
Medication: Aspirin	0.5	0.7	2.5	-0.2	0.6	0.6	0.6	-0.5	-1.6	0.9
Supplements: Vitamin C	0.2	0.2	1.1	-0.4	0.1	-0.3	-1.1	0.3	-0.5	0.2
Knee pain experienced in last month	2.2	3.4	4.3	-2.1	-1.8	-1.9	-1.2	1.9	2.0	-1.9
Hypertension (Self-reported)	0.5	1.4	2.3	-1.2	-1.3	-1.3	-0.9	0.1	1.5	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.7	-1.6	-1.2	-1.4	0.4	1.3	-0.0	-1.0
Illnesses of father: Heart disease	0.4	0.6	2.1	-1.4	-1.0	-0.8	0.5	0.0	0.4	-0.3
Illnesses of siblings: Diabetes	2.8	3.5	6.2	1.4	2.1	2.3	-0.4	-0.5	-2.5	2.5
Smoking status: Previous	0.9	1.4	4.6	-0.0	0.4	0.4	-2.1	2.0	-0.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	2.8	1.4	1.7	1.3	-0.7	-0.6	-0.8	1.5
Whole body fat-free mass	0.3	1.9	3.3	0.9	1.7	1.6	-0.3	-1.2	-1.5	1.8
Leg fat-free mass (right)	0.9	5.0	8.2	1.7	2.8	2.6	-0.9	-1.2	-2.5	2.9
Arm fat percentage (left)	0.6	2.5	4.5	1.2	2.1	1.6	-0.2	-0.0	-2.1	2.1
Average weekly red wine intake	0.4	0.5	1.1	-0.5	-0.9	-0.8	-0.1	-0.4	1.0	-0.9
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	0.2	-0.1	-0.2	0.0	-0.4	0.5	0.0
Mood swings	1.1	2.0	7.3	-0.9	-1.0	-1.0	-1.2	2.7	1.1	-0.9
Loneliness, isolation	1.1	1.5	2.4	-1.6	-1.5	-1.2	-0.3	-1.1	1.0	-1.4
Long-standing illness, disability or infirmity	0.3	0.5	1.7	-0.6	-0.3	-0.4	0.7	1.3	0.1	-0.5
Ever had bowel cancer screening	0.3	0.4	1.8	-0.1	0.3	0.2	1.3	0.2	-0.7	0.4
Diabetes diagnosed by doctor	0.5	0.8	1.1	1.0	0.9	1.1	-1.1	0.3	-1.0	0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.8	1.9	6.6	-1.2	-1.2	-1.3	0.4	2.6	1.0	-1.0
Friendships satisfaction	0.2	0.3	0.6	0.7	0.3	0.6	0.4	-0.7	-0.4	0.6
Qualifications: nursing, teaching	1.6	2.4	4.5	1.6	1.6	1.8	0.4	-0.9	-2.1	1.8
Commuting to job workplace: Walk	0.3	0.3	1.7	0.2	0.5	0.3	-1.3	-0.2	-0.3	0.4
Eye problems/disorders: Cataract	0.2	0.2	0.7	-0.0	0.2	0.3	-0.8	0.6	0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.0	-0.3	0.0	-0.1	-1.0	1.4	-0.4	-0.2
Medication for cholesterol	1.4	2.1	3.5	1.4	1.7	1.7	-0.1	-0.7	-1.7	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.0	4.7	7.5	-2.2	-2.5	-2.6	1.2	0.1	2.4	-2.7
Back pain experienced in last month	0.9	1.3	1.9	-1.4	-1.3	-1.4	0.3	1.2	0.9	-1.3
Mineral and other dietary supplements	2.3	3.1	6.8	1.5	2.1	1.9	0.4	-0.9	-2.6	2.0
Breast cancer (self-reported)	0.3	0.3	0.9	-0.4	0.3	0.2	0.9	-0.8	-0.4	0.6
Asthma (self-reported)	0.2	0.4	1.0	-0.3	-0.6	-0.6	0.5	1.0	0.6	-0.6
Osteoporosis (self-reported)	0.9	1.1	3.9	0.8	0.2	0.4	-2.0	1.6	0.3	-0.0
Osteoarthritis (self-reported)	1.5	1.9	3.5	-1.1	-1.5	-1.6	0.7	0.1	1.9	-1.9
Medication: Aspirin	0.3	0.4	1.6	-0.4	0.3	0.3	-0.1	-0.5	-1.3	0.7
Medication: Gliclazide	0.3	0.3	1.1	-0.3	0.1	0.3	0.8	-1.1	-0.2	0.3
Illnesses of father: None of the above (group 1)	0.1	0.2	0.9	0.1	0.2	0.2	0.2	1.0	0.4	-0.1
Smoking status: Current	2.7	4.2	6.5	-1.6	-2.1	-2.4	1.1	1.9	2.4	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	4.6	1.2	0.9	1.0	-0.5	-2.1	-0.9	0.8
Whole body water mass	0.3	2.0	3.3	0.9	1.7	1.6	-0.3	-1.3	-1.6	1.8
Leg predicted mass (right)	0.9	4.7	7.9	1.7	2.8	2.6	-0.9	-1.2	-2.5	2.8
Arm fat mass (left)	0.5	2.0	3.8	1.0	1.9	1.5	-0.3	-0.1	-1.9	1.9
Number of self-reported non-cancer illnesses	0.7	1.3	4.5	-1.2	-0.7	-0.8	-1.0	2.1	0.7	-0.7
Average weekly champagne plus white wine intake	0.9	1.2	3.1	0.8	0.8	1.0	-0.1	-1.8	-1.5	1.0
Miserableness	1.1	1.9	3.4	-1.5	-1.2	-1.5	-0.4	1.8	1.5	-1.3
Guilty feelings	0.0	0.1	0.3	-0.2	-0.0	0.1	0.5	-0.3	-0.1	0.2
Wears glasses or contact lenses	0.1	0.2	0.4	-0.2	0.3	0.2	-0.6	0.3	-0.6	0.4
Ever taken oral contraceptive pill	0.9	1.1	1.7	-1.3	-1.1	-1.2	0.7	0.8	0.7	-1.1
Hearing aid user	1.8	2.1	3.8	1.7	1.5	1.5	-2.0	0.3	-1.1	1.3
Mother’s age at death	1.5	1.9	3.1	1.2	1.4	1.5	-0.6	-1.3	-1.5	1.7
Financial situation satisfaction	1.1	1.4	2.9	-1.7	-1.2	-1.1	0.4	-0.2	1.5	-1.1
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.8	-0.5	-0.1	-0.1	1.7	1.3	-0.4	0.1
Commuting to job workplace: Public transport	0.7	0.8	2.2	0.8	1.0	0.8	0.4	0.7	-1.5	0.7
Eye problems/disorders: Glaucoma	1.1	1.3	1.9	1.1	1.3	1.4	-0.8	1.0	-0.8	1.3
Medication: Blood pressure	2.2	4.1	7.2	-1.9	-2.3	-2.2	0.7	1.0	2.7	-2.6
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.7	-0.3	-0.5	-0.5	0.8	0.3	-0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.8	-1.0	-1.4	-1.3	0.0	0.8	1.7	-1.3
High cholesterol (Self-reported)	0.2	0.3	0.9	-0.6	-0.2	-0.2	-0.9	0.8	-0.2	0.1
Medication: Bendroflumethiazide	0.3	0.4	2.2	0.1	-0.3	-0.1	-0.8	-1.5	0.2	-0.4
Medication: Paracetamol	0.2	0.2	1.3	-0.3	-0.0	-0.3	-1.1	0.1	0.4	-0.1
Medication: Lisinopril	0.3	0.4	1.4	-0.3	-0.6	-0.6	-0.3	1.2	0.6	-0.5
Medication: Atorvastatin	0.8	0.9	1.7	-0.7	-0.9	-1.0	0.0	1.1	1.3	-1.2
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.2	0.3	0.3	-1.1	-0.7	-1.1	0.5
Alcohol drinker status: Never	0.6	0.7	1.3	1.1	1.1	1.1	0.2	-0.0	-0.5	0.9
Ever smoked	0.6	1.0	4.0	-0.1	-0.1	-0.1	-1.7	2.0	0.3	0.1
Basal metabolic rate	0.4	2.2	3.7	1.0	1.9	1.7	-0.3	-1.2	-1.7	1.9
Leg fat percentage (left)	0.1	0.3	0.9	-0.6	-0.4	-0.5	1.0	0.5	-0.2	-0.2
Arm fat-free mass (left)	0.0	0.2	0.7	-0.2	0.2	0.2	0.1	-0.8	-0.3	0.4
Number of operations (self-reported)	0.6	1.0	4.0	-0.6	-0.2	0.1	-2.0	1.4	-0.5	0.1
Average weekly beer plus cider intake	0.3	0.4	1.1	-1.1	-0.5	-0.6	-0.0	0.1	0.8	-0.4
Irritability	0.5	0.9	2.3	-1.3	-0.9	-0.9	-0.4	1.5	0.3	-0.6
Risk taking	0.8	1.2	2.8	-1.1	-1.1	-1.2	0.9	1.7	0.0	-1.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.1	0.0	-0.5	-0.3	-0.7	2.0	0.4	-0.8
Fractured/broken bones in last 5 years	0.1	0.2	0.6	-0.0	0.1	0.5	-0.2	0.5	-0.8	0.2
Age started oral contraceptive pill	0.7	0.9	4.9	0.2	0.4	0.5	0.3	-2.2	-0.8	0.5
Diastolic blood pressure, automated reading	0.5	1.5	3.1	-0.5	-1.1	-1.5	0.6	-0.3	1.8	-1.8
Ever depressed for a whole week	2.1	2.6	3.9	1.5	1.6	1.7	-2.0	1.0	-2.0	1.5
Unable to work because of sickness or disability	1.4	1.8	10.2	-0.9	-0.4	-0.9	-0.6	3.2	0.6	-0.4
Commuting to job workplace: Cycle	1.2	1.4	2.4	1.1	1.2	1.6	-1.3	-0.2	-0.9	1.5
Myopia	0.2	0.2	0.9	0.2	0.2	0.1	0.8	-0.9	-0.2	0.2
Vascular/heart problems diagnosed by doctor	0.9	2.5	3.9	1.7	1.8	2.0	0.4	-0.4	-1.8	1.9
Cholesterol lowering medication	0.3	0.4	1.2	-1.1	-0.7	-0.8	-0.0	0.2	0.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	5.0	-2.1	-2.0	-2.2	1.1	2.2	1.6	-2.0
Pain experienced in last month	0.8	1.3	6.0	0.0	-0.7	-0.4	2.4	-0.7	1.1	-0.8
Supplements: Calcium	0.5	0.6	2.0	0.5	0.6	0.6	-1.4	0.6	-0.6	0.8
Basal cell carcinoma (self-reported)	0.4	0.4	1.3	0.4	-0.4	-0.3	-1.2	-0.5	0.7	-0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	-0.6	-0.3	-0.6	-0.2	0.7	0.4	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.5	-1.2	-0.6	-1.0	0.3	0.3	1.6	-0.7
Heart disease (siblings)	0.3	0.3	2.3	0.1	0.1	0.1	0.3	1.5	0.1	-0.1
Alcohol drinker status: Previous	0.4	0.5	1.7	0.6	-0.0	-0.1	-0.8	1.3	0.8	-0.5
Pack years of smoking	0.9	1.4	2.0	-1.4	-1.0	-1.4	1.3	0.7	0.9	-1.2
Impedance of whole body	0.3	1.5	2.8	1.7	1.5	1.1	0.0	-1.5	-0.7	1.1
Leg fat mass (left)	0.1	0.4	1.0	0.2	0.8	0.5	0.3	-0.2	-1.0	0.9
Arm predicted mass (left)	0.1	0.3	1.3	-0.2	0.3	0.3	0.3	-1.1	-0.6	0.6