Best TWAS P=1.75e-15 · Best GWAS P=1.34e-12 conditioned to 0.0133
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | MBNL1-AS1 | 0.12 | 0.00 | enet | 26 | 0.02 | 1.7e-02 | -7.1 | -6.4 | 1.6e-10 | 0.62 | 0.02 | 0.90 | FALSE |
| 2 | GTEx | Esophagus Muscularis | MBNL1 | 0.10 | 0.07 | lasso | 6 | 0.04 | 1.7e-03 | -6.2 | -5.1 | 2.9e-07 | 0.13 | 0.14 | 0.33 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC401093 | 0.04 | 0.01 | blup | 25 | 0.03 | 3.0e-06 | -4.5 | -8.0 | 1.8e-15 | 0.66 | 0.01 | 0.97 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC401093 | 0.04 | 0.01 | lasso | 2 | 0.03 | 5.3e-04 | -5.4 | -7.2 | 8.4e-13 | 0.63 | 0.03 | 0.25 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC401093 | 0.09 | 0.09 | lasso | 4 | 0.08 | 8.2e-09 | -5.4 | -5.3 | 8.7e-08 | 0.83 | 0.03 | 0.97 | FALSE |