Hub : Genes

MBNL1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.035	0.0170	1.7e-02	0.005	0.007	0.001	0.006	0.001	7.3e-02	4.2e-02	2.5e-01	0.057	2.4e-01
2	GTEx	Cells EBV-transformed lymphocytes	0.168	0.0600	2.9e-03	0.106	NA	0.074	NA	0.113	2.6e-04	NA	2.1e-03	NA	1.6e-04
3	GTEx	Cells Transformed fibroblasts	0.097	0.0350	1.6e-03	0.047	NA	0.067	NA	0.056	1.8e-04	NA	1.0e-05	NA	4.8e-05
4	GTEx	Colon Sigmoid	0.245	0.0810	1.5e-03	0.062	NA	0.080	NA	0.060	3.1e-03	NA	8.8e-04	NA	3.7e-03
5	GTEx	Esophagus Muscularis	0.100	0.0420	7.2e-03	0.066	NA	0.030	NA	0.040	7.5e-05	NA	5.8e-03	NA	1.7e-03
6	GTEx	Heart Left Ventricle	0.141	0.0534	4.7e-03	0.002	NA	0.000	NA	-0.005	2.5e-01	NA	3.2e-01	NA	9.7e-01
7	TCGA	Prostate Adenocarcinoma	0.190	0.0630	5.1e-12	0.075	0.143	0.147	NA	0.115	2.6e-08	9.7e-15	3.6e-15	NA	4.5e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.7	1.0	2.3	-0.1	0.9	-1.2	0.1	-1.5	-1.4	-0.8
Bipolar Disorder or Schizophrenia	0.4	0.9	3.1	-0.1	1.5	0.3	1.7	-0.7	0.6	-0.3
Depressed Affect (Nagel 2018)	1.1	2.3	9.9	-0.5	-3.1	-0.8	-0.2	-1.4	-0.5	1.7
Depression (Nagel 2018)	2.2	3.2	13.3	-1.9	-3.6	1.4	0.1	-0.8	-0.2	1.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	7.7	0.4	0.4	2.8	1.1	1.1	1.6	-0.3
Neuroticism (Nagel 2018)	0.7	1.8	5.7	-1.1	-2.4	-0.4	0.8	-1.3	-0.3	1.7
Schizophrenia (2018)	0.8	1.7	4.7	-0.1	1.2	1.3	2.2	0.3	1.9	0.2
Schizophrenia vs Biploar Disorder	1.5	2.0	4.3	-1.9	-0.8	2.1	0.0	0.9	2.0	0.8
Worry (Nagel 2018)	0.5	1.0	1.5	-1.2	-1.2	-0.5	1.1	-1.2	-0.2	1.0
Alzheimer’s Disease (in mother)	0.8	1.0	2.9	-0.7	-1.7	-0.5	-0.3	-0.4	-0.9	1.4
Alzheimer’s Disease (in father)	0.8	0.9	1.9	1.1	0.6	-0.5	1.4	-0.6	-1.4	0.2
Alzheimer’s Disease (including proxy)	2.0	2.9	7.0	0.7	-1.0	-2.5	0.4	-2.0	-2.6	1.3
Crohns Disease (2017)	0.5	1.0	2.5	0.8	0.2	1.6	-0.4	1.3	1.5	-0.2
Irritable Bowel Disease (IBD)	0.5	1.2	4.3	1.0	-0.6	2.1	-1.3	0.6	0.5	0.0
Ulcerative Colitis (UC)	0.6	1.1	3.1	1.1	-0.6	1.7	-1.7	0.6	-0.1	-0.2
Major Depression (MDD)	1.6	1.9	5.1	-2.3	-1.6	-0.7	1.4	-0.3	1.1	1.4
Reaction Time	1.4	2.6	7.3	0.5	-0.9	-1.7	-1.2	-2.3	-2.7	0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.3	2.5	0.8	0.6	1.6	1.6	1.0	1.4	-0.6
Breast Cancer	0.1	0.3	0.9	0.1	-0.3	-0.8	-1.0	-0.2	-0.4	-0.4
Ovarian Cancer	0.8	1.0	4.9	0.6	-0.9	-2.2	-0.7	-0.8	0.4	-0.2
Prostate Cancer	5.7	8.1	18.3	-4.3	-3.9	2.0	-0.0	2.9	1.5	2.9
Age at First Birth	2.0	2.9	5.6	0.9	1.2	2.1	1.9	2.4	2.0	-0.7
Bipolar Disorder (2011)	0.9	0.9	2.9	0.4	0.7	-0.7	-0.9	-1.7	-0.8	-0.9
Body Mass Index (BMI) (2010)	1.0	1.3	4.1	0.9	-0.0	0.0	-1.2	-2.0	-1.6	-0.7
Coronary Artery Disease (CAD)	0.1	0.1	0.7	-0.1	-0.1	0.0	0.4	0.1	-0.3	-0.9
Crohns Disease (2012)	0.8	1.4	3.5	1.2	1.1	1.0	-1.9	0.7	-0.2	-1.4
Mean Putamen Volume	3.9	4.4	14.4	0.4	-0.7	3.8	-2.2	3.1	0.9	-0.1
Fasting Glucose	2.8	3.4	12.1	-1.5	-3.5	-1.4	0.3	0.3	0.8	2.5
HbA1C	1.5	1.7	6.0	0.2	-1.1	1.5	0.5	1.4	2.4	-0.6
HDL Cholesterol	0.7	1.2	5.8	-0.2	0.9	0.8	-0.4	2.4	0.8	-0.5
LDL Cholesterol	0.7	1.1	2.8	0.1	0.7	1.7	-0.6	1.4	1.3	-0.5
Lupus	0.2	0.3	1.0	-0.2	0.2	0.8	0.6	0.4	-1.0	0.0
Neuroticism (2016)	2.1	3.0	6.1	-1.4	-2.3	-1.5	0.6	-2.0	-1.0	2.5
Primary Biliary Cirrhosis	0.8	1.2	2.4	1.5	0.8	1.4	-1.2	0.0	-0.1	-1.4
Rheumatoid Arthritis	1.7	2.4	6.4	1.5	0.8	2.5	-0.8	0.8	0.3	-2.5
Schizophrenia (2014)	0.6	1.3	3.3	0.0	1.3	1.8	1.3	0.0	1.5	0.2
Triglycerides	0.3	0.4	0.7	-0.5	0.7	0.6	0.7	-0.8	-0.7	-0.6
Type 2 Diabetes (T2D) (2012)	2.0	2.3	6.6	-2.6	-1.3	-1.2	2.4	0.1	-0.3	0.8
Ulcerative Colitis	1.1	1.6	3.8	1.2	0.0	2.0	-1.3	1.4	0.3	-1.5
Blood Eosinophil Count	0.7	5.6	16.3	0.9	1.2	0.1	-3.1	-3.3	-4.0	-0.1
Blood Platelet Count	0.3	3.7	7.5	-2.7	-0.4	1.8	0.9	2.7	1.9	1.8
Blood Red Count	0.2	1.6	7.5	-2.7	1.3	-0.7	1.2	0.3	0.0	0.3
Blood White Count	0.4	2.6	7.7	1.1	2.0	0.2	-1.4	-0.5	-2.8	-1.9
Heel T-Score	0.2	1.9	4.7	1.4	-0.2	-2.1	0.5	-1.0	2.2	-1.2
BMI	0.6	3.5	8.2	0.2	-1.4	0.2	-2.2	-2.9	-2.0	2.2
Height	0.5	10.3	26.3	3.8	-3.7	-0.2	-0.8	-5.1	-4.1	-0.5
Waist Hip Ratio (WHR)	0.4	2.0	9.7	1.1	-0.1	-3.1	0.8	-0.2	1.4	-0.6
Systolic Blood Pressure	0.4	2.1	4.6	2.0	-1.4	0.4	-1.1	-2.1	0.2	-1.6
Smoking Status	0.9	2.1	8.9	-2.0	-3.0	-0.8	0.0	0.1	0.9	0.9
Allergy or Eczema	1.6	4.2	9.1	-3.0	-1.6	-0.3	-1.9	-1.3	-2.1	2.7
Cardiovascular Disease	0.4	1.2	2.6	0.6	-1.6	-1.4	1.0	-1.3	0.6	0.3
Hypothyroidism (self reported)	0.2	0.4	1.9	0.6	-1.4	-0.5	0.4	0.5	0.2	-0.1
Respiratory disease	0.3	0.7	2.2	-1.5	-0.4	-0.3	0.8	0.4	0.1	1.3
Type 2 Diabetes (T2D) (2018)	2.6	4.9	10.3	-2.8	-3.2	-1.9	1.3	-1.6	-0.8	2.9
Lung FEV1/FVC ratio	1.6	8.2	25.7	-2.8	-5.1	0.7	-1.3	-0.8	-0.7	4.5
Lung FVC	1.8	8.9	22.4	3.2	3.8	4.7	0.7	1.2	3.2	-1.7
Neuroticism	0.9	2.1	6.2	-1.0	-2.5	-0.3	0.3	-1.8	-0.9	1.9
Chronotype (morning person)	1.4	3.3	6.4	-2.5	0.6	-0.2	2.4	2.1	2.2	1.1
Hair Pigment	0.3	8.3	28.0	-2.6	-0.2	-2.7	-3.8	-0.8	-5.3	0.9
Tanning	0.2	2.2	4.3	2.1	1.6	1.0	-1.9	-1.0	-0.7	-1.7
Hand grip strength (left)	1.2	3.1	7.4	0.5	1.0	2.7	1.4	1.9	2.7	-0.0
Number of treatments/medications taken	0.3	0.6	2.6	-0.1	-1.6	-1.2	0.3	-0.2	-0.2	-0.2
Average weekly spirits intake	0.5	0.6	1.0	-1.0	-1.0	-0.6	-0.3	0.8	0.4	0.9
Sensitivity / hurt feelings	0.6	1.1	2.5	-0.8	0.8	-0.3	1.6	1.2	1.4	-0.3
Frequency of depressed mood in last 2 weeks	1.1	1.5	5.0	-0.3	-2.2	0.1	0.1	-1.7	-1.0	1.2
Hearing difficulty/problems: Yes	0.6	0.9	2.1	0.6	1.4	1.2	0.8	-0.1	1.0	-0.9
Relative age of first facial hair	3.2	6.7	17.1	-0.7	-0.5	2.2	3.5	3.4	4.1	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.7	-0.1	-1.3	-0.6	-0.6	-0.1	0.5	-0.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.6	-0.6	0.1	0.2	0.8	-0.7	-0.1	-0.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.7	1.2	1.1	0.2	-0.5	-1.6	-0.1	-0.4
Systolic blood pressure, automated reading	1.0	3.0	7.9	2.5	-0.8	-0.2	-2.8	-1.9	-0.2	-1.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.1	0.6	-0.5	1.1	-0.9	-0.1	-1.0	-0.8
Angina	1.0	1.4	6.1	-0.7	0.0	-2.5	0.8	-1.0	-1.1	0.5
Medication for hormone replacement therapy	0.3	0.3	1.4	-0.7	-0.3	-0.3	-0.3	-0.5	-1.2	-0.3
Vitamin and mineral supplements	1.8	2.4	7.5	1.6	2.7	-0.1	0.5	-0.9	-0.2	-2.4
Supplements: Zinc	2.1	2.3	6.7	-0.2	-1.2	2.6	-1.8	0.5	0.7	1.9
Medication: Co-codamol	1.7	2.0	9.6	0.4	-1.4	3.1	-1.1	0.8	-0.3	0.5
Medication: Metformin	1.1	1.5	2.5	-1.1	-1.5	-1.6	-0.1	-1.5	-1.5	0.3
Diabetes (father)	1.5	1.8	5.5	-0.1	-0.9	-1.8	-0.3	-2.4	-1.6	0.7
Diabetes (mother)	1.4	1.8	8.5	-1.0	-2.9	-0.3	0.2	-0.1	0.8	1.4
Severe depression (siblings)	0.6	0.7	1.9	-0.1	0.5	0.3	-1.4	-0.8	-1.1	0.7
Pack years adult smoking proportion	0.8	1.3	6.2	1.0	0.6	-2.5	0.2	-0.7	-0.6	-0.7
Impedance of leg (right)	0.2	0.8	2.2	-1.1	0.5	0.6	0.7	1.5	1.1	0.3
Leg fat-free mass (left)	0.7	3.7	7.1	2.0	-2.6	-0.6	-1.2	-2.7	-2.5	0.1
Trunk fat percentage	0.4	1.7	4.5	0.1	-0.8	-1.1	-2.0	-1.3	-2.1	0.4
Hand grip strength (right)	1.1	3.1	7.1	1.4	1.2	2.4	1.6	1.6	2.7	-0.6
Townsend deprivation index at recruitment	1.7	2.3	5.7	-0.5	-1.9	-2.4	1.1	-1.3	-0.1	1.9
Current tobacco smoking	0.5	0.8	4.5	-0.8	-2.1	-0.3	-0.0	0.3	0.6	0.5
Average weekly fortified wine intake	0.8	0.9	2.8	-0.1	1.7	1.4	-0.7	-0.1	-0.6	-0.7
Maternal smoking around birth	0.7	1.0	3.5	1.9	0.6	-0.2	0.1	-1.1	0.2	-1.3
Fed-up feelings	1.2	2.3	8.1	0.7	-2.8	-0.7	-1.7	-1.4	-1.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	8.7	-1.0	-3.0	1.0	-0.1	-1.5	-0.5	1.3
Relative age voice broke	1.8	2.8	6.5	-0.3	-0.3	2.4	1.9	2.0	2.5	0.4
Taking other prescription medications	0.4	0.6	2.1	-0.7	-0.4	-1.5	0.1	-1.0	-0.8	-0.3
Age when periods started (menarche)	1.4	3.4	8.8	-0.1	1.0	-0.3	2.5	3.0	2.7	-0.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.4	0.7	1.2	-0.3	-0.7	-0.8	-0.2	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	-0.4	-0.4	-1.3	1.2	0.2	1.1	0.3
Tinnitus: Yes, but not now, but have in the past	1.2	1.2	4.0	0.1	-0.2	1.5	0.3	2.0	1.5	0.4
Qualifications: CSEs or equivalent	1.0	1.3	4.2	-0.5	-2.1	1.0	-0.7	1.6	0.6	0.3
Serious illness, injury or assault to yourself	0.7	0.8	2.4	0.1	-1.5	-1.1	-1.0	0.1	-0.5	1.0
High blood pressure	0.3	0.9	3.0	1.0	-0.3	-0.9	-0.6	-1.7	-0.7	-0.8
Hayfever, allergic rhinitis or eczema	1.9	4.2	11.2	-3.2	-1.9	-0.6	-0.8	-1.1	-1.4	3.3
Multivitamins +/- minerals	2.3	2.9	8.7	-0.9	-2.9	0.9	-0.1	1.6	1.4	2.4
Stomach or abdominal pain in last month	0.9	1.1	2.9	-0.7	-1.7	-1.1	-0.9	0.4	0.4	1.4
Supplements: Glucosamine	1.5	2.0	5.5	0.8	0.4	1.6	-1.4	2.3	1.3	-1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	8.6	-1.2	-0.6	-2.9	1.3	0.2	0.9	0.3
Medication: Atenolol	0.5	0.6	2.0	-0.3	-1.4	0.7	0.4	0.5	0.7	0.8
Medication: Levothyroxine sodium	0.2	0.3	0.9	0.8	0.2	-0.9	-0.1	0.7	0.1	0.1
Sitting height	1.2	8.2	23.1	2.0	-4.3	-2.0	0.8	-4.8	-2.2	1.5
Chronic bronchitis/emphysema (father)	0.5	0.5	1.2	1.0	-0.9	0.4	0.2	-1.1	-0.7	-0.3
High blood pressure (mother)	0.9	1.3	4.1	-0.6	0.4	0.6	0.2	2.0	2.0	-0.3
Body mass index (BMI)	0.3	1.1	3.8	0.2	-1.3	-0.3	-1.9	-1.1	-1.0	0.5
Impedance of leg (left)	0.1	0.7	2.3	-1.5	-0.0	-0.3	0.4	1.1	0.7	0.6
Leg predicted mass (left)	0.7	3.5	6.7	2.0	-2.5	-0.5	-1.2	-2.6	-2.5	0.1
Trunk fat mass	0.6	2.5	6.3	0.8	-1.3	-1.1	-1.9	-2.0	-2.5	0.3
Waist circumference	0.4	1.6	4.0	1.0	-0.9	-1.5	-2.0	-1.2	-1.4	-0.1
Number of incorrect matches in round	0.8	1.3	5.0	0.7	-0.9	-1.5	0.2	-2.2	0.8	0.2
Past tobacco smoking	0.3	0.5	1.1	-0.0	0.3	1.0	-0.2	1.1	0.4	0.9
Alcohol usually taken with meals	1.4	2.3	6.9	0.9	2.6	1.5	0.2	0.9	-0.2	-2.3
Nervous feelings	0.5	1.0	3.2	-0.9	-1.0	-0.7	0.3	-1.8	-0.4	1.2
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	2.7	-1.0	-1.6	0.6	-0.6	-0.9	-0.9	1.1
Hearing difficulty/problems with background noise	0.5	0.9	1.9	1.3	0.6	1.4	0.8	-0.8	0.6	-0.6
Hair/balding pattern: Pattern 2	1.0	1.3	7.5	-0.9	-0.1	2.7	-0.1	0.7	-0.0	-0.5
Had menopause	0.3	0.3	0.8	-0.9	-0.6	0.5	-0.2	0.6	0.6	-0.2
Had other major operations	0.4	0.5	1.5	1.0	0.3	0.1	-0.5	-0.4	-0.9	-1.2
Forced vital capacity (FVC)	0.5	2.1	7.9	2.8	-0.6	2.0	0.5	-0.9	1.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.2	0.1	0.0	-1.8	1.3	-0.2	1.4	-0.7
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.3	-1.5	-1.5	0.8	0.5	0.4	0.8	2.1
Qualifications: None of the above	0.7	1.6	5.2	0.4	-0.2	-1.3	1.7	1.0	2.3	0.1
Financial difficulties in last 2 years	0.7	1.0	4.6	-0.3	-2.1	0.1	-1.3	-0.0	-0.0	0.7
Mouth/teeth dental problems	0.7	1.1	3.6	0.3	1.9	0.5	0.8	0.8	0.3	-1.6
Heart attack	0.3	0.4	1.2	-0.1	-0.7	-1.1	0.0	-0.2	-0.9	0.5
Allergy	1.6	3.8	7.5	2.7	2.0	0.7	1.2	1.9	2.2	-2.1
Pain all over the body in last month	1.3	1.4	3.9	-0.8	-0.8	0.1	-0.7	-1.6	-1.3	2.0
Diabetes (self-reported)	4.0	6.2	11.7	-1.6	-3.1	-3.4	0.1	-3.0	-2.8	1.7
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	11.3	-1.8	-2.2	-0.3	-1.1	-0.4	0.3	3.4
Medication: Ramipril	1.5	1.9	5.2	1.1	-0.9	-1.6	-0.7	-2.3	-1.6	-0.5
Medication: Simvastatin	0.5	0.7	1.7	1.3	-0.4	-1.3	0.1	-0.7	-0.2	-0.9
Fluid intelligence score	0.7	1.4	5.2	0.7	0.9	2.3	0.8	0.9	1.0	-1.1
Illnesses of siblings	0.5	0.6	1.7	-1.1	0.4	0.9	1.3	0.4	-0.0	0.7
Neuroticism score	0.7	1.4	3.9	0.2	-2.0	-1.3	0.3	-1.5	-0.8	1.2
Weight	0.7	3.5	6.5	1.4	-2.5	-0.6	-1.9	-2.5	-2.4	0.6
Impedance of arm (right)	0.1	0.4	1.1	-0.7	0.7	0.4	0.5	1.1	-0.5	0.3
Arm fat percentage (right)	0.3	1.0	4.5	0.3	-0.1	0.1	-2.1	-0.7	-1.3	0.3
Trunk fat-free mass	0.6	3.2	8.4	2.3	-2.9	0.1	-0.4	-2.3	-1.7	0.1
Hip circumference	0.7	2.9	6.3	0.3	-1.7	-0.4	-2.5	-1.8	-2.4	1.3
Time employed in main current job	1.2	1.3	4.6	-0.5	-0.7	-0.8	-2.2	-0.5	-0.5	1.7
Alcohol intake versus 10 years previously	0.2	0.3	1.1	1.0	-0.5	0.5	0.0	0.3	0.6	-0.3
Father’s age at death	0.9	1.2	3.3	0.4	0.8	-1.8	-0.3	-1.0	-1.1	-1.5
Worrier / anxious feelings	0.4	0.7	2.2	-1.5	-0.2	0.6	0.8	0.2	-0.6	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.4	0.3	-1.6	-0.9	0.0	-1.6	-1.0	0.7
Falls in the last year	1.3	1.7	3.9	-2.0	-1.7	0.6	-0.4	1.6	1.2	1.0
Hair/balding pattern: Pattern 3	3.1	4.6	14.2	3.2	1.1	-0.1	-3.8	-2.4	-0.7	-0.2
Number of live births	0.9	1.3	4.3	-0.7	-1.6	0.9	-0.0	-0.5	0.8	2.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.0	2.2	-1.2	2.2	0.7	-0.5	1.5	0.8
Pulse rate	1.2	2.0	5.2	-2.3	-1.7	-0.8	0.6	1.3	0.7	1.6
Happiness	2.9	3.5	9.7	-2.0	-3.1	0.0	0.9	0.0	0.7	3.1
Noisy workplace	0.9	1.1	1.9	-1.3	-0.8	-0.6	0.6	1.4	1.1	1.3
Qualifications: A levels/AS levels or equivalent	0.8	1.7	7.8	-1.2	0.7	2.8	1.1	0.9	-0.6	0.1
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.8	6.7	0.6	0.2	2.6	-1.2	1.4	1.2	-0.8
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.2	-0.6	0.2	-0.6	-0.3	-0.6	-0.1
Asthma	0.2	0.5	1.6	-0.4	-0.6	-0.7	-0.7	-0.5	-1.3	-0.1
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	5.5	-0.8	-1.9	2.4	0.5	0.9	0.8	-0.2
Medication: Cholesterol lowering	2.2	3.4	6.4	2.2	0.5	-2.4	-0.7	-2.5	-2.1	-1.2
Depression (self-reported)	0.1	0.1	0.3	0.2	-0.2	-0.2	-0.0	-0.3	0.6	-0.5
Medication: Lansoprazole	1.4	1.5	3.1	-1.3	-1.0	-1.8	0.7	-1.4	-0.7	1.5
Prospective memory result	2.2	2.7	5.9	-2.0	-2.4	-1.2	1.2	1.3	1.1	1.7
Lung cancer (father)	0.7	0.8	1.5	0.9	0.6	-1.1	0.1	-1.2	-1.1	-0.6
Illnesses of mother	0.5	0.7	1.3	1.0	0.2	0.9	-0.6	-1.1	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	7.5	2.7	-1.5	2.4	0.7	-1.2	1.2	0.6
Pulse wave Arterial Stiffness index	0.5	0.6	2.0	-1.1	0.5	-0.4	-0.2	1.4	0.3	-0.4
Impedance of arm (left)	0.2	0.8	2.4	-1.1	1.0	0.4	0.5	1.6	-0.5	0.3
Arm fat mass (right)	0.4	1.8	3.8	0.6	-1.5	-0.2	-2.0	-1.6	-1.8	0.6
Trunk predicted mass	0.6	3.2	8.4	2.4	-2.9	0.1	-0.4	-2.3	-1.7	0.1
Standing height	0.5	5.2	10.4	2.6	-3.2	-0.9	0.1	-3.1	-3.0	0.1
Length of working week for main job	0.3	0.3	1.5	0.0	1.2	0.6	-0.1	0.7	0.4	0.0
Exposure to tobacco smoke at home	0.3	0.3	1.3	0.0	-0.3	-0.8	-1.1	0.1	-0.3	0.5
Breastfed as a baby	0.4	0.5	1.9	-0.4	0.7	1.4	0.1	-0.8	0.1	0.2
Tense / ‘highly strung’	0.4	0.7	2.1	0.1	-1.4	-0.3	-0.3	-1.4	0.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.3	-1.0	-1.5	-1.4	-0.9	0.0	-0.3	1.1
Hair/balding pattern: Pattern 4	7.5	18.1	59.2	7.7	2.0	-1.3	-4.3	-5.1	-2.9	-2.9
Birth weight of first child	1.1	2.0	3.8	1.9	-1.9	1.0	1.7	-0.9	1.2	0.7
Peak expiratory flow (PEF)	0.7	1.7	5.5	2.3	-0.5	2.1	0.3	0.1	1.4	-0.3
Pulse wave reflection index	0.2	0.3	1.1	0.1	0.4	-0.1	0.3	-1.0	-0.3	-0.7
Ever highly irritable/argumentative for 2 days	2.3	2.8	9.9	-1.0	-3.2	-0.5	-1.3	0.8	0.5	2.4
Loud music exposure frequency	2.0	2.2	8.6	-0.4	-2.9	1.0	-0.9	0.9	-0.1	2.0
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	1.0	-0.1	1.3	-0.4	-0.1	-0.9	-1.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.1	1.1	-1.5	0.4	-0.2	0.1	0.5	0.8
Blood clot in the leg (DVT)	1.2	1.6	2.7	-0.9	-1.1	-1.0	-1.6	-1.6	-1.6	-0.5
Medication: Paracetamol	1.5	2.4	5.9	-0.9	-2.4	-1.4	-1.2	-2.1	-1.1	1.2
Headache pain in last month	0.9	1.6	5.6	-1.2	-1.4	2.4	-0.3	1.0	0.1	1.0
Medication for cholesterol, blood pressure or diabetes	2.0	3.4	7.2	-2.2	-0.9	2.3	0.2	2.7	2.2	0.9
Glaucoma (self-reported)	0.6	0.7	2.1	-0.2	1.4	-0.6	-0.1	1.4	0.7	-0.4
Gout (self-reported)	1.9	2.7	8.0	-0.2	0.5	1.9	1.5	2.1	2.8	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.9	1.1	-0.1	-1.7	0.4	-0.2	-0.4	-0.5
Medication: Amlodipine	0.8	1.1	4.5	0.4	0.8	-2.1	0.5	-0.8	-0.0	-1.2
Medication: Ventolin 100micrograms inhaler	0.7	0.9	2.2	-1.5	-1.0	0.6	0.5	0.3	-0.5	1.4
Birth weight	0.7	1.5	6.9	2.6	-0.4	1.2	-0.6	0.6	1.2	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.4	-0.6	-0.3	0.3	0.4	0.2	0.5
High blood pressure (siblings)	1.4	2.0	6.5	2.5	1.3	-1.1	-1.6	-0.5	0.1	-1.3
Forced vital capacity (FVC), Best measure	0.8	2.9	11.9	3.4	-0.6	2.4	0.3	-1.2	0.8	-0.5
Body fat percentage	0.3	1.3	4.3	-0.1	-0.6	-0.7	-2.1	-1.1	-1.5	0.4
Leg fat percentage (right)	0.1	0.5	2.5	0.0	-0.4	-0.0	-1.6	-0.7	-0.5	0.6
Arm fat-free mass (right)	0.7	3.5	8.4	1.8	-2.9	-0.7	-0.8	-2.8	-1.9	0.2
Exposure to tobacco smoke outside home	0.3	0.4	1.9	0.9	-0.1	-0.1	-0.3	0.2	1.4	-0.1
Comparative body size at age 10	0.3	0.8	3.1	-1.0	-0.2	0.7	-1.8	-0.2	-0.7	0.3
Number of full brothers	0.3	0.4	1.2	-0.4	0.0	-1.0	-0.2	-0.3	-0.5	1.1
Worry too long after embarrassment	0.1	0.1	0.3	0.4	0.5	0.3	0.6	-0.0	0.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	2.0	-0.7	-1.1	-1.4	-0.2	-0.3	-0.5	0.3
Wheeze or whistling in the chest in last year	0.7	1.3	3.3	-1.0	0.4	-0.7	-1.8	-0.8	-1.8	-0.0
Number of children fathered	0.5	0.5	1.2	-0.6	-0.9	0.9	-1.1	0.5	0.5	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.9	-1.2	-0.1	0.2	1.2	0.5	2.0	0.6
Age at first live birth	0.9	1.7	5.2	1.0	2.3	1.9	0.1	0.5	0.3	-1.2
Pulse wave peak to peak time	0.7	0.8	2.6	1.3	-0.8	0.4	0.3	-1.6	-0.6	0.4
Health satisfaction	2.1	2.7	7.6	-1.9	-2.7	-1.0	-0.0	0.0	0.3	2.5
Shortness of breath walking on level ground	2.9	3.4	14.8	-0.7	-3.8	-0.7	-0.6	0.0	0.3	2.8
Qualifications: College or University degree	0.2	0.5	1.1	-0.6	-0.8	1.0	1.0	-0.4	-0.6	0.4
Eye problems/disorders: None of the above	1.1	1.2	4.1	-1.4	-0.4	-0.1	0.5	-2.0	-0.4	1.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	0.9	0.7	-0.4	-0.9	0.1	-0.4	0.3	1.0
Emphysema/chronic bronchitis	0.5	0.5	1.3	1.0	0.2	-0.3	-0.7	-0.7	-0.6	-1.1
Medication for pain relief, constipation, heartburn	0.6	1.1	5.1	0.6	2.3	0.3	-0.6	1.3	-0.1	-0.1
Neck or shoulder pain in last month	0.7	1.0	3.9	-0.6	-1.3	-0.4	-2.0	0.5	0.1	-0.9
Medication: Blood pressure	1.3	2.2	4.1	1.9	1.1	-1.3	-0.1	-1.8	-2.0	-1.3
Angina (self-reported)	1.2	1.6	6.5	-1.0	-0.0	-2.5	0.9	-1.1	-1.0	0.7
Migraine (self-reported)	0.5	0.7	2.5	-1.0	-0.5	0.8	-0.1	1.6	-0.3	0.4
Medication: Ibuprofen	0.9	1.1	3.6	-0.5	-1.9	1.8	0.0	0.2	0.3	0.5
Medication: Allopurinol	0.8	1.1	2.5	0.9	1.6	0.5	0.9	0.7	1.5	-0.6
Medication: Omeprazole	0.5	0.6	1.6	-0.4	-0.5	1.3	-0.7	0.7	1.0	0.6
Medication: Seretide 50 evohaler	0.6	0.7	1.4	-0.9	0.2	1.1	1.2	0.6	1.0	-0.1
Mean time to correctly identify matches	1.2	2.2	5.7	1.0	0.1	-2.0	-1.1	-1.9	-2.4	-0.6
Heart disease (mother)	1.4	1.7	3.5	-0.6	-1.8	-0.6	-1.9	0.1	-1.1	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.5	-0.6	-1.0	1.7	-0.1	0.4	0.8	1.9
Whole body fat mass	0.5	2.0	3.8	0.4	-1.4	-1.0	-1.9	-1.8	-2.0	0.4
Leg fat mass (right)	0.4	1.5	3.0	0.6	-1.1	-0.3	-1.7	-1.7	-1.5	0.5
Arm predicted mass (right)	0.6	3.2	8.7	1.7	-3.0	-0.6	-1.0	-2.5	-1.9	0.3
Pulse rate, automated reading	0.5	1.5	5.9	-2.4	-1.1	-1.4	0.8	0.4	-0.1	0.8
Alcohol intake frequency.	0.1	0.3	1.7	0.2	-0.1	-1.3	0.2	-0.1	-0.1	-0.3
Comparative height size at age 10	1.2	6.5	16.1	1.7	-2.4	-2.2	-1.1	-4.0	-3.7	1.1
Number of full sisters	1.0	1.2	2.4	0.8	-0.7	-1.6	-0.7	-1.5	-0.9	1.1
Suffer from ‘nerves’	0.3	0.5	1.4	-0.7	-1.2	0.5	0.8	-0.7	-0.2	0.7
Overall health rating	1.4	3.1	9.9	-2.3	-3.1	-1.1	0.2	0.0	-0.0	2.2
Chest pain or discomfort	1.1	1.6	4.6	-2.0	-1.6	-0.1	-0.0	0.5	-0.4	2.1
Had major operations	1.1	1.3	4.3	0.4	2.1	0.5	0.8	1.3	1.1	-0.9
Age at last live birth	1.2	1.7	4.7	-0.2	0.0	2.2	0.3	1.3	1.8	1.3
Family relationship satisfaction	1.2	1.5	5.7	0.2	-1.7	0.2	0.5	0.3	2.4	1.1
Leg pain on walking	0.7	0.9	2.5	-0.9	-0.4	0.3	1.4	0.6	1.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.7	-1.7	-1.9	-0.2	-0.6	0.4	-0.9	1.3
Commuting to job workplace: Car/motor vehicle	1.3	1.5	4.3	0.7	2.1	0.8	-0.7	1.1	0.3	-1.8
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.1	-0.3	1.8	-0.3	2.0	-1.0	-1.3	-0.3
Medication: Aspirin	0.9	1.2	3.2	-0.3	-1.5	-1.5	1.8	-0.1	0.2	0.6
Supplements: Vitamin C	1.2	1.5	3.5	-1.0	-1.4	0.4	-1.9	-0.7	-1.5	1.1
Knee pain experienced in last month	1.9	2.9	6.1	-0.0	0.3	2.5	-0.8	2.3	1.7	-2.4
Hypertension (Self-reported)	0.5	1.4	4.4	1.1	-0.2	-1.5	-0.6	-2.1	-0.8	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.1	-0.5	-0.6	-1.1	0.3	-0.3	0.4	-0.4
Illnesses of father: Heart disease	1.0	1.3	5.1	1.3	2.2	0.4	0.3	0.0	1.0	-1.1
Illnesses of siblings: Diabetes	3.8	4.7	13.3	-2.4	-3.6	-2.2	0.9	-0.4	-0.3	2.8
Smoking status: Previous	0.9	1.3	3.2	0.4	0.4	-1.7	-0.5	-1.8	-1.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.7	0.6	-1.2	1.1	0.3	-0.7	-1.6	-0.3
Whole body fat-free mass	0.7	3.7	8.4	2.3	-2.9	-0.3	-0.8	-2.7	-2.1	0.0
Leg fat-free mass (right)	0.8	4.1	7.9	2.1	-2.6	-0.9	-1.3	-2.8	-2.7	-0.1
Arm fat percentage (left)	0.3	1.1	4.8	-0.0	-0.3	-0.0	-2.2	-0.7	-1.4	0.3
Average weekly red wine intake	0.7	1.0	2.7	0.5	0.5	1.3	1.4	0.0	1.6	-0.2
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	1.0	-0.9	0.7	-0.8	0.5	-0.3	-1.0
Mood swings	0.7	1.3	3.7	-0.7	-1.5	-1.1	0.7	-0.6	0.2	1.9
Loneliness, isolation	1.1	1.6	3.1	-0.4	-1.6	-1.1	0.2	-1.5	-1.2	1.8
Long-standing illness, disability or infirmity	0.5	0.8	2.2	-0.1	-0.7	0.3	-0.5	-1.5	-1.1	-1.1
Ever had bowel cancer screening	0.6	0.7	2.7	0.0	1.2	-0.3	1.6	-0.8	-0.2	0.0
Diabetes diagnosed by doctor	3.1	5.1	11.9	-2.2	-3.5	-2.8	1.1	-1.8	-1.3	2.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	3.8	-1.0	-1.1	-1.0	0.2	-1.4	-0.8	1.9
Friendships satisfaction	3.5	4.3	12.5	-2.6	-3.2	0.1	-0.6	-0.0	0.1	3.5
Qualifications: nursing, teaching	1.3	2.1	8.6	0.4	0.5	2.9	-1.3	0.5	-0.8	-1.6
Commuting to job workplace: Walk	0.5	0.5	1.0	-1.0	-1.0	-0.3	1.0	0.4	0.3	0.7
Eye problems/disorders: Cataract	0.3	0.4	0.7	0.8	-0.3	-0.7	-0.6	0.8	0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	2.2	0.3	-1.0	1.2	-1.1	-1.5	0.0	1.2
Medication for cholesterol	1.3	2.0	4.5	1.2	1.8	-0.3	-0.6	-2.0	-2.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.8	17.2	2.2	0.6	-0.4	-0.5	-4.2	-1.5	-1.1
Back pain experienced in last month	1.1	1.5	4.5	1.0	-1.6	0.4	-0.9	-2.1	-0.9	-0.9
Mineral and other dietary supplements	1.2	1.7	4.8	1.4	0.1	-2.2	1.0	-1.8	-0.3	-0.7
Breast cancer (self-reported)	1.6	1.9	4.7	1.1	-0.2	0.8	-1.8	-2.2	-1.8	0.5
Asthma (self-reported)	0.1	0.2	0.5	-0.4	-0.3	-0.7	-0.4	-0.3	-0.7	-0.2
Osteoporosis (self-reported)	1.0	1.2	5.1	-0.8	0.1	-0.5	0.6	-1.4	-2.3	0.3
Osteoarthritis (self-reported)	0.8	1.0	2.4	0.1	-1.6	1.3	-1.2	-0.3	-1.0	0.8
Medication: Aspirin	0.6	0.8	2.0	-0.5	-1.4	-1.4	1.2	-0.1	0.1	0.5
Medication: Gliclazide	0.7	0.8	2.2	-0.0	-0.5	-1.5	-0.2	-1.3	-1.2	0.2
Illnesses of father: None of the above (group 1)	0.2	0.3	0.8	-0.5	-0.9	-0.2	-0.7	-0.3	-0.4	-0.2
Smoking status: Current	0.8	1.2	5.3	-1.1	-2.3	0.1	0.1	0.7	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	11.2	2.1	1.4	3.3	-0.8	-0.4	1.7	-1.0
Whole body water mass	0.7	3.9	8.8	2.3	-3.0	-0.2	-1.0	-2.7	-2.1	0.2
Leg predicted mass (right)	0.7	4.0	7.9	2.1	-2.5	-0.9	-1.2	-2.8	-2.7	-0.1
Arm fat mass (left)	0.4	1.8	4.0	0.5	-1.6	-0.1	-2.0	-1.6	-1.8	0.6
Number of self-reported non-cancer illnesses	0.9	1.5	3.2	-0.9	-1.8	-1.7	0.1	-1.2	-1.1	1.1
Average weekly champagne plus white wine intake	0.2	0.3	0.9	0.1	0.0	-0.8	-0.1	1.0	0.8	-0.2
Miserableness	0.7	1.2	5.9	0.3	-2.4	0.2	0.1	-0.9	0.1	1.1
Guilty feelings	0.8	1.2	3.2	-0.0	-0.4	0.4	-1.2	-1.2	-1.4	1.8
Wears glasses or contact lenses	0.9	1.0	2.6	-0.5	1.3	-0.2	-1.0	-0.0	-1.6	-1.2
Ever taken oral contraceptive pill	0.9	1.0	3.3	1.5	-0.3	1.8	-0.5	-0.8	-0.2	-0.6
Hearing aid user	0.6	0.7	2.0	-0.8	1.4	0.2	1.2	0.2	0.8	0.1
Mother’s age at death	1.4	1.7	3.9	0.7	1.4	1.7	0.5	1.4	0.4	-2.0
Financial situation satisfaction	0.7	0.8	3.1	-0.0	-1.7	-0.8	-1.0	0.2	-0.1	1.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	1.1	0.7	1.1	-0.7	0.7	-0.3	-1.1
Commuting to job workplace: Public transport	0.5	0.6	2.0	-0.2	-0.6	-1.2	0.2	-0.5	-0.2	1.4
Eye problems/disorders: Glaucoma	0.6	0.7	2.4	0.2	1.6	-0.9	-0.6	0.9	-0.0	-0.8
Medication: Blood pressure	0.3	0.5	1.2	0.2	-1.1	-0.1	-1.0	-0.4	0.9	-0.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	-1.0	-0.7	0.2	-0.9	-0.8	0.2	-0.5
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.6	-1.3	-0.1	1.1	0.1	2.1	1.1	0.6
High cholesterol (Self-reported)	0.7	1.3	4.5	0.1	-1.2	0.2	0.6	2.1	1.6	-0.5
Medication: Bendroflumethiazide	0.8	1.2	3.6	1.0	-0.2	-0.0	-1.9	-1.0	-0.9	-1.4
Medication: Paracetamol	1.6	2.5	6.2	-0.8	-2.1	-1.6	-1.0	-2.5	-1.4	0.9
Medication: Lisinopril	0.2	0.3	0.6	0.1	-0.7	0.2	-0.7	-0.6	-0.5	0.4
Medication: Atorvastatin	0.3	0.4	1.2	0.4	0.8	-0.2	0.6	0.7	1.1	-0.2
Illnesses of father: High blood pressure	0.3	0.4	1.4	0.0	-1.0	-0.5	-0.5	0.1	0.2	1.2
Alcohol drinker status: Never	0.1	0.1	0.6	0.0	0.7	-0.2	0.5	0.2	0.2	0.3
Ever smoked	0.7	1.2	3.7	-0.3	-1.9	-0.8	0.1	-1.6	-1.0	0.4
Basal metabolic rate	0.7	3.7	8.6	2.0	-2.9	-0.4	-1.1	-2.7	-2.2	0.3
Leg fat percentage (left)	0.2	0.9	3.3	-0.1	-0.8	-0.6	-1.8	-0.9	-0.7	0.7
Arm fat-free mass (left)	0.8	4.0	9.7	1.9	-3.1	-0.6	-1.0	-3.1	-1.9	0.6
Number of operations (self-reported)	0.3	0.4	2.1	-0.0	1.5	0.4	-0.1	0.5	0.6	-0.3
Average weekly beer plus cider intake	0.5	0.7	2.1	0.4	-1.4	-0.5	0.4	1.0	1.1	0.6
Irritability	0.9	1.4	7.3	1.1	-2.7	-0.3	-0.7	0.2	-0.3	0.9
Risk taking	1.4	2.1	6.4	-1.3	-2.2	0.2	-2.5	-0.2	-0.8	1.0
Ever had prostate specific antigen (PSA) test	1.9	2.2	8.1	1.6	1.7	-0.9	-0.8	0.2	-0.4	-2.9
Fractured/broken bones in last 5 years	0.7	0.8	3.2	-0.7	0.1	0.1	-0.8	1.8	1.2	-0.3
Age started oral contraceptive pill	1.5	1.9	4.6	-0.1	2.1	2.0	-0.3	0.9	0.5	-1.8
Diastolic blood pressure, automated reading	1.0	3.0	8.4	1.1	-0.8	-2.8	-1.3	-2.9	-1.3	-0.4
Ever depressed for a whole week	0.6	0.8	2.2	-0.6	-1.5	-0.6	0.4	-0.6	0.1	1.4
Unable to work because of sickness or disability	0.7	0.9	2.4	-1.1	-1.5	0.2	1.0	1.0	-0.1	0.5
Commuting to job workplace: Cycle	0.7	0.9	1.9	0.7	0.6	1.3	0.7	1.0	1.4	-0.5
Myopia	0.4	0.6	1.4	0.7	1.0	1.2	-0.1	0.2	0.4	-1.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.5	-1.0	0.4	1.1	0.3	1.6	0.4	0.3
Cholesterol lowering medication	2.0	2.9	8.8	-1.1	-1.6	0.4	1.2	2.5	3.0	0.1
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.6	-0.5	-0.6	1.2	-0.9	0.4	0.5	0.6
Pain experienced in last month	1.0	1.6	3.9	0.9	2.0	-1.8	1.2	-0.7	-1.2	-0.2
Supplements: Calcium	1.6	1.8	5.4	-0.4	2.1	2.3	0.4	1.4	-0.2	-0.5
Basal cell carcinoma (self-reported)	0.5	0.6	1.3	1.1	0.7	-1.1	-0.4	-0.6	-0.6	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.7	0.2	-0.3	-1.3	0.1	-0.2	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.3	1.6	2.9	-0.9	-0.9	-1.1	-1.5	-1.7	-1.7	-0.7
Heart disease (siblings)	0.3	0.4	1.0	0.8	-0.6	-0.3	-1.0	-0.7	-0.3	0.0
Alcohol drinker status: Previous	0.4	0.5	2.2	-0.2	-0.5	-1.5	-0.8	-0.3	-0.5	0.1
Pack years of smoking	1.2	1.7	6.9	1.2	1.3	-2.6	-0.2	-0.6	-0.8	-1.0
Impedance of whole body	0.1	0.7	2.2	-1.5	0.7	-0.3	0.8	1.3	0.1	0.4
Leg fat mass (left)	0.6	2.2	4.3	0.6	-1.4	-0.8	-2.1	-2.0	-1.9	0.6
Arm predicted mass (left)	0.7	3.8	9.1	1.9	-3.0	-0.5	-1.0	-3.0	-1.9	0.4