TWAS hub - LOC401093

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0377	0.0171	8.4e-06	0.005	0.026	0.026	NA	0.026	2.4e-02	3.0e-06	3.1e-06	NA	3.3e-06
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0408	0.0203	1.2e-03	0.014	0.024	0.025	NA	0.026	8.2e-03	9.1e-04	7.3e-04	NA	5.3e-04
3	TCGA	Lung Squamous Cell Carcinoma	0.0304	0.0172	4.8e-03	0.031	0.023	0.025	NA	0.028	1.9e-04	1.0e-03	7.4e-04	NA	3.1e-04
4	TCGA	Prostate Adenocarcinoma	0.0908	0.0390	5.3e-08	0.087	0.080	0.067	NA	0.081	2.2e-09	9.0e-09	1.4e-07	NA	8.2e-09
5	TCGA	Thyroid Carcinoma	0.0770	0.0360	4.2e-05	0.010	0.025	0.014	NA	0.019	3.2e-02	1.6e-03	1.4e-02	NA	5.0e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Fed-up feelings	4.3	7.7	13.5	-3.7	-3.6	1.9	-1.6	-2.4
Number of full brothers	4.0	5.0	10.2	1.1	2.2	0.8	3.2	2.9
Ever had prostate specific antigen (PSA) test	3.8	4.4	6.8	-0.5	-1.8	-2.2	-2.6	-2.6
Hayfever, allergic rhinitis or eczema	3.6	7.8	15.9	2.1	4.0	2.3	3.4	1.3
Prostate Cancer	3.5	5.0	21.3	1.5	-0.6	4.6	0.8	-0.3
Supplements: Zinc	3.5	3.8	4.5	2.1	1.8	1.9	2.1	1.9
Illnesses of siblings: Diabetes	2.9	3.6	13.1	-0.0	0.1	3.6	2.0	0.8
Friendships satisfaction	2.9	3.6	8.5	0.2	1.8	2.9	2.4	0.7
Chronotype (morning person)	2.7	6.3	9.2	2.9	3.0	0.4	2.3	2.9
Hayfever/allergic rhinitis (self-reported)	2.7	3.5	9.5	0.6	1.6	3.1	2.1	0.7
Fasting Glucose	2.6	3.1	12.1	0.0	-0.5	3.5	1.8	0.4
Diabetes (self-reported)	2.6	4.1	10.6	-3.3	-2.2	2.0	0.4	1.0
Number of children fathered	2.6	2.9	5.2	2.2	0.7	1.5	2.3	1.5
Health satisfaction	2.4	3.2	7.2	0.3	1.3	2.7	2.5	0.9
Ulcerative Colitis	2.3	3.4	5.5	-1.0	-2.2	-0.7	-2.3	-2.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.0	6.6	-2.4	-1.5	2.6	0.6	-0.2
Allergy	2.3	5.4	10.2	-1.8	-2.9	-1.9	-3.2	-1.2
Sitting height	2.2	15.3	47.2	-6.9	-4.7	0.1	-2.6	-0.6
Diabetes diagnosed by doctor	2.2	3.7	6.8	-2.5	-1.8	2.6	0.8	1.3
Mineral and other dietary supplements	2.2	2.9	7.1	-2.7	-2.3	-0.9	-0.9	0.8
Risk taking	2.2	3.3	6.3	1.3	1.6	2.5	2.4	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	8.3	-2.9	-1.4	-1.3	-0.4	0.4
Depressed Affect (Nagel 2018)	2.0	4.2	6.9	-2.6	-2.3	2.4	-0.3	-1.6
Alzheimer’s Disease (including proxy)	2.0	2.8	10.3	-3.2	-1.2	-0.7	-1.1	0.9
Mean Putamen Volume	2.0	2.3	5.8	2.4	0.5	2.0	0.8	-0.8
Hair/balding pattern: Pattern 2	2.0	2.5	10.6	-0.5	-1.0	0.2	-0.9	-3.3
Medication: Blood pressure	2.0	3.6	5.3	-2.1	-1.8	-2.0	-2.3	-0.9
Comparative height size at age 10	2.0	10.9	35.6	-6.0	-3.3	-0.7	-2.4	-1.1
Alzheimer’s Disease (in father)	1.9	2.1	4.2	-1.8	-0.4	-2.0	-1.2	1.2
Major Depression (MDD)	1.9	2.3	3.7	1.1	1.3	1.9	1.9	1.2
Type 2 Diabetes (T2D) (2018)	1.9	3.5	8.9	-1.6	-0.9	3.0	1.9	1.4
Medication: Ramipril	1.9	2.4	5.0	-2.2	-1.9	-0.1	-1.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	8.9	-3.0	-2.3	0.6	-0.7	-0.5
Back pain experienced in last month	1.9	2.8	5.7	-2.3	-2.4	-0.1	-1.5	-1.0
Depression (Nagel 2018)	1.8	2.7	9.4	-1.4	-0.7	3.1	1.3	0.1
Pain all over the body in last month	1.8	1.9	4.0	-0.4	1.2	1.0	1.7	2.0
Alcohol intake versus 10 years previously	1.8	2.7	7.3	-1.4	-2.7	0.7	-1.4	-1.3
Standing height	1.8	17.6	37.0	-6.1	-5.0	-0.8	-4.3	-2.6
Breastfed as a baby	1.8	2.2	5.5	1.9	2.4	0.1	1.1	-0.9
Irritability	1.8	3.0	6.2	-1.6	-2.5	1.9	-0.6	-1.6
Blood White Count	1.7	12.9	24.7	-2.3	-3.3	-2.5	-5.0	-4.1
Allergy or Eczema	1.7	4.5	8.6	1.5	2.9	2.2	2.5	0.6
Age when periods started (menarche)	1.7	4.0	14.5	3.8	2.0	-0.2	0.9	0.8
Happiness	1.7	2.0	6.7	-1.2	-0.6	2.6	0.8	0.9
Medication: Cholesterol lowering	1.7	2.6	6.1	-2.5	-1.9	-1.0	-1.4	-0.7
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	6.7	-1.7	-1.9	-1.1	-2.6	-1.4
Heart disease (mother)	1.7	2.0	3.3	0.8	1.8	1.6	1.8	0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.7	2.0	4.8	0.6	0.6	2.2	1.8	1.1
Chest pain or discomfort	1.7	2.4	4.1	1.3	1.1	2.0	1.6	1.5
Schizophrenia vs Biploar Disorder	1.6	2.1	4.7	1.5	2.2	1.1	1.4	-0.4
Blood Red Count	1.6	15.8	28.5	4.4	3.7	0.5	4.2	5.3
Height	1.6	30.6	63.4	-8.0	-7.2	-1.5	-5.3	-2.7
Alcohol usually taken with meals	1.6	2.6	6.5	2.3	1.2	-2.5	-0.3	0.1
Medication: Lansoprazole	1.6	1.8	4.0	0.4	2.0	0.7	1.7	1.4
Hair/balding pattern: Pattern 4	1.6	3.8	9.1	-1.1	-1.2	-2.7	-0.2	3.0
Medication for cholesterol, blood pressure or diabetes	1.6	2.7	6.7	2.6	1.5	1.5	1.4	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	4.9	-2.1	-1.8	-0.6	-2.0	-2.2
Commuting to job workplace: Public transport	1.6	1.9	3.9	0.5	1.3	0.6	1.8	2.0
Supplements: Calcium	1.6	1.8	4.2	1.4	0.8	-2.0	-1.2	-0.8
HbA1C	1.5	1.6	4.0	0.6	-1.6	2.0	0.2	-1.0
Tense / ‘highly strung’	1.5	2.4	6.2	-2.5	-2.1	1.2	-0.4	0.0
Ulcerative Colitis (UC)	1.4	2.5	4.1	-1.8	-2.0	-0.2	-1.8	-1.4
Hypothyroidism (self reported)	1.4	3.1	5.9	-1.8	-2.4	0.0	-2.4	-0.9
Townsend deprivation index at recruitment	1.4	1.9	6.1	-2.5	-0.8	1.5	0.2	-0.7
Qualifications: CSEs or equivalent	1.4	1.8	4.6	-0.5	-1.0	1.6	-1.0	-2.1
Hair/balding pattern: Pattern 3	1.4	2.0	7.0	1.1	0.8	-0.2	1.1	2.6
Number of live births	1.4	2.0	3.7	0.4	1.7	1.3	1.3	1.9
Prospective memory result	1.4	1.7	8.0	0.4	-0.2	2.8	0.6	-0.4
Headache pain in last month	1.4	2.3	7.8	-1.0	-0.5	0.9	-1.4	-2.8
Shortness of breath walking on level ground	1.4	1.7	6.6	-0.8	-0.0	2.6	1.0	0.6
Loneliness, isolation	1.4	1.9	6.0	-2.4	-0.9	1.5	0.4	-0.6
Neuroticism	1.3	3.2	7.0	-2.6	-2.2	2.1	-0.2	-0.2
Average weekly fortified wine intake	1.3	1.5	3.2	1.6	1.8	-0.7	0.9	0.7
Supplements: Glucosamine	1.3	1.7	4.4	2.1	1.0	0.2	-0.1	-1.8
Chronic bronchitis/emphysema (father)	1.3	1.5	3.5	-1.9	-1.7	0.2	-1.1	0.1
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.3	0.9	1.3	1.5	1.1	1.4
Depression (self-reported)	1.3	1.5	3.1	-1.8	-1.8	0.8	-0.8	-0.4
Gout (self-reported)	1.3	1.8	5.3	2.3	1.6	0.3	0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.6	6.0	-0.3	-0.4	1.3	-0.5	-2.4
Supplements: Fish oil (including cod liver oil)	1.3	1.7	4.5	2.1	1.6	0.6	0.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	3.0	0.6	0.7	1.1	1.7	1.7
Smoking Status	1.2	2.9	8.4	-1.5	-1.3	2.9	-0.5	-1.4
Respiratory disease	1.2	2.6	4.2	1.8	1.6	1.0	2.1	1.4
Severe depression (siblings)	1.2	1.4	2.5	0.9	1.6	0.5	1.4	1.1
Multivitamins +/- minerals	1.2	1.6	6.3	0.6	0.4	2.5	1.0	-0.3
Stomach or abdominal pain in last month	1.2	1.5	4.5	0.3	0.3	2.1	1.6	-0.2
Neuroticism score	1.2	2.5	7.1	-2.7	-1.9	1.0	-0.7	-0.4
Falls in the last year	1.2	1.7	4.9	1.2	0.7	2.2	1.2	0.1
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.4	-0.5	-1.5	0.9	-1.6	-1.3
Ever highly irritable/argumentative for 2 days	1.2	1.4	6.3	-0.5	-0.1	2.5	0.5	-0.3
Wheeze or whistling in the chest in last year	1.2	2.2	4.4	1.8	1.4	0.4	2.1	1.2
Illness, injury, bereavement, stress in last 2 years	1.2	1.4	4.5	0.3	1.5	-2.1	-0.4	0.0
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	2.2	-0.4	1.4	0.7	1.3	1.5
Commuting to job workplace: Walk	1.2	1.3	2.0	0.9	1.4	1.3	1.4	0.4
Tinnitus: Yes, now most or all of the time	1.2	1.4	2.5	-0.4	-0.0	-1.6	-1.5	-1.5
Neuroticism (2016)	1.1	1.7	6.4	-2.5	-0.6	1.1	0.1	-0.6
Lung FVC	1.1	5.7	11.5	2.4	3.4	-2.7	0.2	2.0
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.2	-2.0	-1.3	1.4	-0.0	-0.2
Medication: Metformin	1.1	1.5	3.6	-1.9	-1.6	1.1	-0.3	0.4
Serious illness, injury or assault to yourself	1.1	1.3	3.3	-0.2	-0.5	1.8	1.1	1.3
Trunk predicted mass	1.1	6.2	14.5	-3.8	-3.4	0.3	-2.1	-0.0
Birth weight of first child	1.1	2.0	4.5	-2.1	-1.9	0.2	-0.6	1.2
Birth weight	1.1	2.3	5.1	-0.8	-2.1	-0.8	-2.2	-0.9
Age at first live birth	1.1	1.9	5.8	0.1	-0.2	-2.4	-1.7	-0.9
Knee pain experienced in last month	1.1	1.8	6.4	2.5	1.1	-0.1	0.0	-1.1
Whole body fat-free mass	1.1	6.5	16.4	-4.0	-3.3	0.2	-2.2	-0.3
Leg fat-free mass (right)	1.1	5.7	14.9	-3.9	-2.8	-0.2	-2.2	-0.8
Whole body water mass	1.1	6.4	16.3	-4.0	-3.3	0.3	-2.1	-0.2
Hearing aid user	1.1	1.3	4.3	0.8	2.1	-0.4	0.8	0.8
Mother’s age at death	1.1	1.4	2.4	1.5	0.7	-1.4	-0.8	-1.2
Cholesterol lowering medication	1.1	1.6	3.9	1.4	0.5	2.0	1.4	0.3
Ever had hysterectomy (womb removed)	1.0	1.1	3.6	-0.9	-0.2	-1.1	0.3	1.9
Diabetes (mother)	1.0	1.3	5.7	-0.2	0.1	2.4	0.9	0.4
Leg fat-free mass (left)	1.0	5.4	14.3	-3.8	-2.8	0.0	-2.1	-0.8
High blood pressure (mother)	1.0	1.4	3.1	1.7	1.8	0.1	0.9	0.4
Leg predicted mass (left)	1.0	5.2	13.8	-3.7	-2.7	0.0	-2.1	-0.8
Trunk fat-free mass	1.0	6.0	14.5	-3.8	-3.4	0.4	-2.0	0.1
Arm fat-free mass (right)	1.0	5.3	13.7	-3.7	-3.1	0.4	-1.7	0.2
Medication: Omeprazole	1.0	1.2	3.0	0.5	0.6	0.9	1.2	1.7
Suffer from ‘nerves’	1.0	1.6	3.5	-1.9	-1.3	0.7	-1.1	-1.1
Illnesses of father: Heart disease	1.0	1.3	5.0	-0.1	1.0	-2.2	-0.8	-0.1
Mood swings	1.0	1.8	3.7	-1.9	-1.4	1.3	-0.3	-1.3
Leg predicted mass (right)	1.0	5.6	14.6	-3.8	-2.8	-0.3	-2.2	-0.8
Basal metabolic rate	1.0	5.6	15.1	-3.9	-3.0	0.4	-1.9	-0.4
Number of operations (self-reported)	1.0	1.4	2.7	1.6	1.5	-0.9	0.9	0.8
Arm predicted mass (left)	1.0	5.2	14.1	-3.8	-3.0	0.6	-1.5	0.5
Lung FEV1/FVC ratio	0.9	4.7	19.3	-0.4	0.9	4.4	1.8	0.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.9	-0.9	-1.3	-0.5	-0.2	1.7
Medication for hormone replacement therapy	0.9	1.0	2.8	-1.0	-1.7	-0.1	-0.8	0.7
Medication: Atenolol	0.9	1.1	3.2	-0.2	-0.9	1.8	0.9	1.0
Trunk fat mass	0.9	3.7	7.4	-2.7	-1.8	0.1	-1.6	-2.3
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.6	-1.6	-1.0	1.5	-0.4	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	2.0	1.4	1.1	0.2	1.0	1.2
Arm predicted mass (right)	0.9	4.8	12.5	-3.5	-2.9	0.6	-1.6	0.2
Average weekly red wine intake	0.9	1.3	4.6	0.9	2.1	-0.1	0.9	0.4
Breast cancer (self-reported)	0.9	1.0	2.4	-1.2	-0.7	-0.4	-0.8	-1.6
Miserableness	0.9	1.6	3.6	-1.4	-1.9	1.5	-0.3	-0.3
Arm fat-free mass (left)	0.9	4.6	12.9	-3.6	-2.8	0.8	-1.1	0.5
Fractured/broken bones in last 5 years	0.9	1.2	2.3	1.4	0.6	1.1	0.4	-1.5
Neuroticism (Nagel 2018)	0.8	1.8	4.8	-2.2	-1.2	1.6	0.3	0.0
Alzheimer’s Disease (in mother)	0.8	0.9	2.7	-1.6	-0.7	1.0	-0.4	0.4
Irritable Bowel Disease (IBD)	0.8	2.0	3.1	-1.6	-1.8	0.2	-1.4	-1.5
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	0.3	0.1	1.6	1.2	0.5
Current tobacco smoking	0.8	1.3	3.6	-0.5	-1.0	1.9	-0.5	-1.2
Relative age voice broke	0.8	1.2	3.7	1.9	0.4	0.9	0.6	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.5	1.6	0.1	0.9	0.5	0.6
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.3	0.8	1.0	0.5	1.1	1.1
Noisy workplace	0.8	1.0	2.7	0.8	0.8	1.6	0.4	-0.9
Qualifications: A levels/AS levels or equivalent	0.8	1.8	4.5	1.9	2.1	-0.5	0.5	0.5
Loud music exposure frequency	0.8	0.8	3.8	-0.2	0.5	1.9	0.2	0.2
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.7	0.2	-0.9	-0.7	-1.6	-1.6
Glaucoma (self-reported)	0.8	0.9	2.2	1.3	0.6	-0.3	-0.6	-1.5
Forced vital capacity (FVC), Best measure	0.8	3.0	7.1	-2.7	-1.1	-1.3	-2.2	-0.5
Eye problems/disorders: None of the above	0.8	0.9	1.5	-0.3	1.1	0.6	1.2	1.2
Neck or shoulder pain in last month	0.8	1.1	2.7	0.1	-1.3	1.0	-0.4	-1.6
Illnesses of father: None of the above (group 1)	0.8	1.0	1.7	1.3	0.0	1.1	1.1	-0.7
Smoking status: Current	0.8	1.2	4.8	-0.0	-0.6	2.2	-0.3	-1.0
Ever taken oral contraceptive pill	0.8	0.9	3.2	-0.8	-1.8	0.0	-0.7	0.4
High cholesterol (Self-reported)	0.8	1.4	4.6	0.8	-0.8	2.2	0.8	-0.5
Average weekly beer plus cider intake	0.8	1.2	3.8	-0.4	-2.0	1.4	0.0	-0.2
Worry (Nagel 2018)	0.7	1.5	3.3	-1.8	-1.6	0.9	-0.4	0.8
Reaction Time	0.7	1.3	3.0	-1.7	-1.5	0.6	0.2	0.9
Crohns Disease (2012)	0.7	1.1	4.5	0.6	-0.3	-0.4	-0.5	-2.1
Rheumatoid Arthritis	0.7	1.0	3.2	0.7	-1.8	-0.6	-0.8	-0.6
Vitamin and mineral supplements	0.7	0.9	4.0	-0.2	-0.4	-2.0	-0.5	0.5
Medication: Co-codamol	0.7	0.8	2.0	-0.7	-1.4	1.3	-0.1	0.1
Diabetes (father)	0.7	0.8	2.5	-1.6	-0.6	0.3	0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.8	0.4	-0.6	-0.4	0.9	1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.3	0.7	0.2	1.3	1.8	1.6
Number of incorrect matches in round	0.7	1.2	3.1	0.1	0.8	0.8	1.3	1.8
Mouth/teeth dental problems	0.7	1.1	3.1	1.8	0.6	-1.3	-0.2	-0.7
Weight	0.7	3.7	11.0	-3.3	-2.2	0.6	-1.3	-0.8
Impedance of arm (right)	0.7	3.5	13.3	-0.2	-0.5	-0.7	-1.8	-3.6
Father’s age at death	0.7	0.9	1.3	-0.7	-1.0	-0.9	-1.1	-0.9
Asthma	0.7	1.3	2.5	1.5	0.9	0.5	1.6	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	2.6	-1.0	-0.7	1.6	0.2	-1.0
Overall health rating	0.7	1.5	5.8	-0.8	-0.6	2.4	0.9	-0.3
Had major operations	0.7	0.8	2.4	-0.1	0.2	-1.5	-1.1	-0.5
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.6	0.6	-0.8	-1.1	-1.3	-0.4
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.7	0.1	-1.3	0.5	-0.8	-1.2
Osteoarthritis (self-reported)	0.7	0.9	2.2	0.3	-0.6	1.5	-0.4	-1.2
Age at First Birth	0.6	0.9	2.2	0.8	-0.5	-0.9	-1.5	-0.8
Waist Hip Ratio (WHR)	0.6	2.9	5.3	-0.8	-2.3	0.1	-1.9	-2.2
Hand grip strength (left)	0.6	1.7	3.9	2.0	1.5	-0.0	0.8	1.3
Trunk fat percentage	0.6	2.3	6.6	-1.7	-0.9	0.3	-1.1	-2.6
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.9	1.0	0.2	0.6	1.7	1.5
Financial difficulties in last 2 years	0.6	0.8	1.7	-0.7	-1.2	1.3	0.1	-0.7
Pulse rate	0.6	1.0	3.3	0.6	0.4	1.8	1.0	-0.2
Impedance of arm (left)	0.6	2.8	10.8	0.5	0.2	-0.8	-1.5	-3.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	3.1	-1.8	-0.5	0.0	-0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.1	0.5	0.5	1.4	1.0	0.6
Emphysema/chronic bronchitis	0.6	0.7	1.3	-1.2	-1.0	-0.5	-0.5	-0.7
Medication: Allopurinol	0.6	0.7	1.9	0.5	0.6	-1.4	-1.0	-0.3
Whole body fat mass	0.6	2.3	5.1	-2.3	-1.4	0.5	-1.0	-1.8
Number of full sisters	0.6	0.7	1.5	-0.5	0.7	0.5	1.1	1.2
Age at last live birth	0.6	0.8	2.1	1.3	1.5	0.4	0.1	-0.4
Supplements: Vitamin C	0.6	0.7	1.3	0.3	1.2	0.8	1.1	0.3
Smoking status: Previous	0.6	0.9	2.8	-1.7	-0.9	-0.7	-0.7	-0.2
Asthma (self-reported)	0.6	1.2	2.1	1.4	0.9	0.4	1.4	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.9	0.1	1.5	-1.7	-0.3	1.2
Guilty feelings	0.6	0.9	2.2	-0.8	0.8	0.4	0.8	1.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	0.8	0.5	-0.8	-0.8	-1.2
Commuting to job workplace: Cycle	0.6	0.7	2.4	0.8	0.5	-0.1	0.4	1.5
Pain experienced in last month	0.6	1.0	2.5	-0.1	0.4	-1.6	0.1	1.6
Schizophrenia (2018)	0.5	1.0	2.7	0.1	1.6	-1.3	-0.6	0.5
HDL Cholesterol	0.5	0.9	2.2	1.5	-0.3	-0.3	-1.1	-1.0
BMI	0.5	3.0	7.2	-0.1	1.6	1.5	2.7	1.6
Systolic Blood Pressure	0.5	2.7	10.4	-1.4	-3.2	0.9	-0.7	0.0
Hearing difficulty/problems: Yes	0.5	0.7	2.6	0.3	0.5	-0.8	0.2	1.6
Relative age of first facial hair	0.5	1.1	4.1	2.0	0.1	0.7	-0.4	-0.8
Systolic blood pressure, automated reading	0.5	1.5	5.5	-1.1	-2.3	0.8	-0.2	-0.6
Hand grip strength (right)	0.5	1.5	2.7	1.7	1.5	-0.7	0.3	1.3
Hearing difficulty/problems with background noise	0.5	0.7	1.4	-1.2	0.4	-1.0	0.1	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.5	5.3	-2.3	-0.7	-0.3	-1.3	0.4
Exposure to tobacco smoke outside home	0.5	0.7	1.3	1.0	0.8	0.5	0.4	-1.1
Pulse wave peak to peak time	0.5	0.6	2.0	-0.6	-1.4	0.3	-0.6	0.1
Angina (self-reported)	0.5	0.7	1.6	0.2	1.1	-0.2	0.8	1.3
Medication: Ibuprofen	0.5	0.6	1.8	-0.6	-0.7	1.3	-0.6	-0.3
Mean time to correctly identify matches	0.5	1.0	2.4	-1.6	-1.4	-0.4	-0.6	-0.0
Family relationship satisfaction	0.5	0.6	1.3	-0.9	-0.3	1.2	0.5	0.8
Ever had bowel cancer screening	0.5	0.5	1.2	-0.3	0.8	-1.1	0.2	0.9
Eye problems/disorders: Cataract	0.5	0.6	1.9	-0.2	-0.8	0.1	-0.6	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	2.1	-1.1	-0.3	0.6	0.3	1.5
Medication for cholesterol	0.5	0.8	2.4	-0.8	0.5	-1.6	-0.3	0.6
Medication: Gliclazide	0.5	0.6	1.3	-1.2	0.1	0.1	0.7	1.1
Number of self-reported non-cancer illnesses	0.5	0.9	1.8	-0.1	0.3	1.4	1.3	0.8
Financial situation satisfaction	0.5	0.6	1.9	-1.4	-0.8	0.6	0.0	0.2
Medication: Paracetamol	0.5	0.8	2.9	-1.7	-0.6	0.8	-0.0	-0.1
Age started oral contraceptive pill	0.5	0.6	2.1	0.6	-0.0	-1.4	-0.8	-0.4
Myopia	0.5	0.8	2.1	1.4	0.8	-1.1	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	-1.0	-0.9	-0.5	-0.9	-0.0
Pack years of smoking	0.5	0.8	1.5	-0.8	-0.5	-1.0	-0.6	-1.2
Ovarian Cancer	0.4	0.5	1.0	-0.4	-1.0	0.6	0.4	0.8
Schizophrenia (2014)	0.4	0.9	2.3	0.3	1.5	-1.2	-0.3	0.8
Cardiovascular Disease	0.4	1.2	2.0	-0.8	-1.0	1.3	0.8	1.4
Number of treatments/medications taken	0.4	0.7	1.4	-1.2	-0.6	0.9	-0.3	-0.9
Pack years adult smoking proportion	0.4	0.6	0.9	-1.0	-0.5	-0.8	-0.6	-0.8
Medication: Levothyroxine sodium	0.4	0.6	1.9	-0.4	-0.6	-0.4	-1.4	-0.7
Waist circumference	0.4	1.3	2.4	-1.6	-1.5	0.5	-0.9	-1.0
Forced vital capacity (FVC)	0.4	1.5	3.5	-1.9	-0.2	-1.1	-1.7	-0.4
Fluid intelligence score	0.4	0.9	3.4	1.9	0.5	-0.4	0.2	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.1	1.0	-0.3	0.5	0.1	0.9
Medication: Paracetamol	0.4	0.7	2.6	-1.6	-0.6	0.8	-0.2	0.0
Medication: Amlodipine	0.4	0.5	1.8	-0.3	-0.2	-1.4	-0.9	0.2
Qualifications: College or University degree	0.4	1.2	3.1	0.3	1.3	0.1	1.0	1.8
Medication for pain relief, constipation, heartburn	0.4	0.8	2.3	1.5	1.1	-0.6	0.1	-0.1
Alcohol intake frequency.	0.4	0.9	2.8	-1.7	-1.1	0.1	-0.2	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	1.1	0.6	0.4	0.4	0.9	1.1
Long-standing illness, disability or infirmity	0.4	0.6	1.4	-1.2	-1.1	-0.0	-0.4	0.7
Qualifications: nursing, teaching	0.4	0.6	1.1	1.0	-0.5	-0.4	-0.9	-1.1
Medication: Aspirin	0.4	0.6	1.0	-0.5	-0.1	0.9	0.9	1.0
Average weekly champagne plus white wine intake	0.4	0.6	1.7	0.7	0.6	-0.4	0.5	1.3
Medication: Bendroflumethiazide	0.4	0.7	2.2	-0.2	-1.0	-0.0	-0.4	-1.5
Medication: Atorvastatin	0.4	0.5	1.4	-0.2	-0.3	-0.7	-1.2	-0.7
Bipolar Disorder or Schizophrenia	0.3	0.8	1.6	-0.2	1.0	-1.3	-0.7	1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.8	2.2	1.2	0.1	-0.2	0.5	1.5
Bipolar Disorder (2011)	0.3	0.3	0.9	-0.5	-0.0	-1.0	-0.5	0.5
Primary Biliary Cirrhosis	0.3	0.5	0.8	-0.6	-0.9	-0.8	-0.7	-0.1
Blood Platelet Count	0.3	3.8	6.7	2.6	2.0	2.2	1.9	0.4
Heel T-Score	0.3	2.6	5.1	0.3	-0.4	1.6	2.3	2.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.7	-0.7	0.9	0.0	-0.3
Angina	0.3	0.3	1.0	0.0	0.7	-0.3	0.4	1.0
Maternal smoking around birth	0.3	0.4	1.1	-0.7	-0.5	-1.1	-0.4	0.3
Nervous feelings	0.3	0.5	2.3	-1.5	0.1	0.1	-0.3	-0.0
Heart attack	0.3	0.4	1.0	-1.0	-0.7	-0.2	-0.7	0.1
Hip circumference	0.3	1.2	4.0	-2.0	-0.8	1.2	0.2	0.3
Time employed in main current job	0.3	0.4	0.9	-0.7	0.1	1.0	0.3	-0.5
Worrier / anxious feelings	0.3	0.5	1.2	0.7	0.5	0.3	0.7	1.1
Mouth/teeth dental problems: Dentures	0.3	0.4	0.7	-0.7	-0.8	0.7	-0.6	-0.5
Lung cancer (father)	0.3	0.4	1.0	-0.7	-0.5	-1.0	-0.1	-0.2
Pulse wave Arterial Stiffness index	0.3	0.3	1.1	0.3	1.1	-0.3	0.4	-0.2
Arm fat mass (right)	0.3	1.4	3.8	-1.9	-1.1	0.7	-0.6	-1.1
Length of working week for main job	0.3	0.3	0.7	0.5	0.8	-0.6	0.3	0.4
Exposure to tobacco smoke at home	0.3	0.3	0.6	0.3	0.8	-0.0	0.7	-0.7
Pulse wave reflection index	0.3	0.4	0.8	-0.9	0.4	-0.9	-0.3	0.3
Body fat percentage	0.3	1.1	3.7	-1.1	-0.5	0.5	-0.5	-1.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	-0.7	0.1	0.4	0.0	0.9
Leg fat mass (right)	0.3	1.1	3.4	-1.8	-0.9	0.6	-0.5	-0.8
Medication: Aspirin	0.3	0.4	0.8	-0.7	-0.2	0.5	0.6	0.9
Arm fat mass (left)	0.3	1.2	2.9	-1.7	-1.0	0.9	-0.5	-1.1
Alcohol drinker status: Never	0.3	0.4	0.9	0.0	0.5	-0.5	0.7	1.0
Ever smoked	0.3	0.5	1.7	-0.8	-0.4	1.3	0.1	-0.2
Ever depressed for a whole week	0.3	0.4	0.8	-0.3	0.9	0.9	0.6	0.4
Basal cell carcinoma (self-reported)	0.3	0.3	0.9	0.4	0.3	-0.7	0.2	-0.9
Impedance of whole body	0.3	1.5	6.3	0.7	0.2	-0.2	-0.8	-2.5
Leg fat mass (left)	0.3	1.2	3.7	-1.9	-0.9	0.7	-0.4	-0.8
Bipolar Disorder (2018)	0.2	0.3	1.1	-0.3	-0.5	-0.5	-0.3	1.1
Crohns Disease (2017)	0.2	0.5	0.8	-0.4	-0.9	0.2	-0.9	-0.9
Triglycerides	0.2	0.3	0.5	0.2	0.5	-0.5	0.7	0.7
Average weekly spirits intake	0.2	0.3	1.0	-0.0	-0.1	1.0	0.4	-0.6
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.4	-0.7	-0.5	-0.1	-0.1	0.4
Impedance of leg (right)	0.2	0.8	3.3	0.7	0.1	0.3	-0.4	-1.8
Impedance of leg (left)	0.2	1.0	3.9	0.8	0.4	0.6	-0.1	-2.0
Had menopause	0.2	0.2	0.5	0.3	-0.2	0.7	0.5	0.4
Medication: Simvastatin	0.2	0.3	0.8	-0.8	-0.9	0.4	0.2	0.0
Arm fat percentage (right)	0.2	0.7	2.7	-0.7	-0.1	0.4	-0.3	-1.6
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.3	-1.5	0.2	-0.3	-1.1	0.2
Illnesses of mother	0.2	0.3	1.1	-0.4	-1.0	-0.2	-0.0	0.2
Peak expiratory flow (PEF)	0.2	0.4	0.7	-0.6	0.0	-0.4	-0.8	0.8
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.7	-0.4	0.5	0.1	-0.6
High blood pressure (siblings)	0.2	0.3	0.8	-0.2	0.1	-0.9	-0.3	-0.6
Pulse rate, automated reading	0.2	0.7	1.9	0.9	0.6	0.7	0.0	-1.4
Leg pain on walking	0.2	0.2	0.6	-0.3	-0.3	0.7	-0.4	-0.2
Hypertension (Self-reported)	0.2	0.5	1.4	-1.2	-0.9	-0.1	-0.2	0.5
Arm fat percentage (left)	0.2	0.7	2.9	-0.5	-0.0	0.5	-0.3	-1.7
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.3	0.5	-0.6	0.3	0.5
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	-0.1	-0.3	0.9	0.8	-0.0
Diastolic blood pressure, automated reading	0.2	0.6	2.6	-1.6	-0.1	-0.2	0.4	0.4
Alcohol drinker status: Previous	0.2	0.3	0.7	0.1	0.3	0.8	0.7	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	0.8	0.1	-0.5	-0.3	-0.0
Breast Cancer	0.1	0.1	0.2	0.5	0.2	0.3	0.4	-0.3
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	-0.4	-0.6	-0.2	0.0	0.4
Coronary Artery Disease (CAD)	0.1	0.1	0.3	-0.1	-0.6	0.3	0.2	-0.1
LDL Cholesterol	0.1	0.2	0.8	0.9	0.2	-0.5	-0.2	0.1
Lupus	0.1	0.1	0.3	0.2	0.5	-0.5	0.0	0.4
Blood Eosinophil Count	0.1	0.7	1.8	-1.3	0.1	-1.3	0.0	-0.2
Hair Pigment	0.1	2.7	6.2	2.0	2.5	0.5	1.7	-0.2
Tanning	0.1	1.4	6.2	-0.2	0.1	-2.5	-0.8	0.4
Sensitivity / hurt feelings	0.1	0.1	0.3	0.6	0.5	-0.3	0.2	-0.2
Taking other prescription medications	0.1	0.2	0.4	-0.3	0.1	0.6	0.6	0.3
High blood pressure	0.1	0.4	0.9	-0.9	-1.0	0.1	-0.2	0.3
Body mass index (BMI)	0.1	0.4	1.2	-0.7	-0.1	1.1	0.6	0.2
Past tobacco smoking	0.1	0.3	0.6	0.8	0.6	-0.1	0.4	0.3
Had other major operations	0.1	0.1	0.3	0.3	-0.5	-0.4	-0.1	-0.1
Qualifications: None of the above	0.1	0.3	0.6	-0.7	-0.7	0.4	0.2	0.0
Illnesses of siblings	0.1	0.2	0.6	-0.3	-0.0	-0.4	-0.1	0.7
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.4	-0.0	0.2	0.6	0.6	-0.1
Leg fat percentage (right)	0.1	0.3	0.9	-0.6	-0.2	1.0	0.2	-0.5
Comparative body size at age 10	0.1	0.4	1.0	0.8	1.0	0.1	0.1	-0.4
Worry too long after embarrassment	0.1	0.2	0.6	-0.2	0.8	-0.6	0.4	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	-0.6	0.3	0.2	0.3	0.2
Migraine (self-reported)	0.1	0.1	0.3	0.4	0.5	0.1	-0.2	0.3
Medication: Seretide 50 evohaler	0.1	0.2	0.4	0.4	0.0	-0.3	-0.4	0.6
Wears glasses or contact lenses	0.1	0.2	0.3	0.4	-0.3	-0.4	-0.3	-0.5
Medication: Blood pressure	0.1	0.2	0.3	-0.3	-0.6	0.6	0.3	-0.1
Medication: Lisinopril	0.1	0.2	0.6	-0.8	-0.3	0.1	-0.3	0.2
Illnesses of father: High blood pressure	0.1	0.1	0.3	-0.4	0.5	0.4	0.2	-0.1
Leg fat percentage (left)	0.1	0.4	1.1	-0.7	0.0	1.1	0.4	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.5	-0.2	-0.2	0.7	-0.1	-0.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.9	0.9	0.6	0.0	-0.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.4	-0.7	-0.3	0.1	0.0	-0.6
Heart disease (siblings)	0.1	0.1	0.3	-0.2	-0.5	0.1	0.0	0.1

Hub : Genes

LOC401093

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Trait associations