Best TWAS P=1.47e-90 · Best GWAS P=3.85e-104 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | FNDC3B | 0.07 | 0.06 | enet | 8 | 0.05 | 3.2e-07 | -21.7 | 20.2 | 1.5e-90 | -0.95 | 0.00 | 1.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NCEH1 | 0.09 | 0.02 | blup | 512 | 0.03 | 3.8e-04 | -3.3 | -5.2 | 2.3e-07 | 0.00 | 0.53 | 0.02 | FALSE |
| 3 | GTEx | Artery Coronary | NCEH1 | 0.22 | 0.00 | lasso | 4 | -0.01 | 7.0e-01 | 6.1 | 5.5 | 3.5e-08 | -0.02 | 0.09 | 0.06 | TRUE |
| 4 | GTEx | Breast Mammary Tissue (Female) | PLD1 | 0.07 | -0.01 | lasso | 1 | 0.01 | 2.2e-01 | 11.1 | 11.1 | 1.5e-28 | -0.46 | 0.05 | 0.06 | FALSE |
| 5 | GTEx | Ovary | TNFSF10 | 0.40 | 0.01 | lasso | 10 | 0.05 | 1.8e-02 | 4.0 | 13.7 | 1.8e-42 | -0.15 | 0.06 | 0.07 | TRUE |
| 6 | GTEx | Pancreas | NCEH1 | 0.20 | 0.00 | lasso | 6 | 0.00 | 6.0e-01 | 3.5 | 8.4 | 2.9e-17 | -0.34 | 0.04 | 0.38 | FALSE |
| 7 | YFS | Blood | TNFSF10 | 0.09 | 0.04 | bslmm | 462 | 0.08 | 1.6e-24 | 10.4 | 9.8 | 7.0e-23 | 0.01 | 1.00 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | FNDC3B | 0.27 | 0.05 | lasso | 6 | 0.08 | 1.8e-03 | 8.5 | -10.4 | 1.9e-25 | 0.05 | 0.06 | 0.28 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FNDC3B | 0.07 | 0.02 | enet | 6 | 0.02 | 3.9e-03 | 15.4 | -14.6 | 2.2e-48 | 0.01 | 0.42 | 0.04 | TRUE |
| 10 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TNFSF10 | 0.17 | 0.11 | lasso | 2 | 0.09 | 6.0e-04 | -8.8 | 8.8 | 2.2e-18 | 0.05 | 0.04 | 0.09 | FALSE |