TWAS hub - TNFSF10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Visceral Omentum	0.1830	0.0670	3.2e-03	0.063	NA	0.044	NA	0.059	3.4e-04	NA	2.5e-03	NA	5.5e-04
2	GTEx	Ovary	0.4030	0.1160	3.3e-03	0.015	NA	0.013	NA	0.055	1.4e-01	NA	1.5e-01	NA	1.8e-02
3	METSIM	Adipose	0.1450	0.0327	1.8e-09	0.052	0.069	0.117	0.116	0.119	2.6e-08	1.6e-10	3.9e-17	6.5e-17	2.1e-17
4	YFS	Blood	0.0872	0.0178	1.7e-14	0.042	0.059	0.066	0.079	0.068	1.0e-13	1.2e-18	1.2e-20	1.6e-24	2.6e-21
5	TCGA	Testicular Germ Cell Tumors	0.1670	0.0830	4.7e-03	0.112	0.040	0.069	NA	0.086	8.8e-05	1.5e-02	1.9e-03	NA	6.0e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Comparative height size at age 10	8.1	44.8	92.9	3.1	9.6	4.8	7.5	6.4
Trunk fat-free mass	5.4	30.8	53.4	2.0	7.3	4.3	7.2	5.1
Trunk predicted mass	5.4	30.8	52.9	2.0	7.3	4.3	7.2	5.2
Sitting height	5.2	37.3	92.8	2.4	9.6	4.0	7.3	4.2
Standing height	4.9	48.4	114.5	2.2	10.7	4.2	8.3	6.0
Forced expiratory volume in 1-second (FEV1), predicted	4.9	10.3	16.7	2.1	4.0	4.1	3.6	1.0
Whole body fat-free mass	4.6	26.6	50.6	1.7	6.3	3.9	7.1	5.0
Whole body water mass	4.6	26.0	49.8	1.6	6.2	3.8	7.1	5.0
Height	4.1	78.2	187.7	2.3	13.7	4.9	9.8	8.8
Arm predicted mass (right)	3.9	20.1	41.9	1.5	5.1	3.5	6.5	4.2
Arm predicted mass (left)	3.8	19.1	35.3	1.1	5.4	3.2	5.9	4.4
Arm fat-free mass (right)	3.6	18.4	37.0	1.3	5.1	3.3	6.1	4.0
Basal metabolic rate	3.6	20.1	40.3	1.4	5.3	3.3	6.3	4.3
Arm fat-free mass (left)	3.6	18.3	34.5	1.2	5.3	3.1	5.9	4.2
Leg predicted mass (left)	3.5	18.6	41.9	1.3	4.6	3.0	6.5	4.4
Leg fat-free mass (left)	3.4	18.0	41.3	1.2	4.5	2.8	6.4	4.3
Leg fat-free mass (right)	3.3	17.7	39.9	1.4	4.4	2.8	6.3	4.4
Leg predicted mass (right)	3.3	17.8	40.0	1.4	4.4	2.9	6.3	4.3
Forced vital capacity (FVC), Best measure	3.2	11.7	30.0	0.7	5.5	2.6	4.1	2.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.8	6.8	-1.1	-2.6	-1.7	-2.6	-1.2
Forced vital capacity (FVC)	3.0	11.6	28.2	1.3	5.3	2.3	4.0	2.6
Age when periods started (menarche)	2.8	6.8	9.4	-2.1	-3.0	-2.3	-3.1	-2.3
Headache pain in last month	2.8	4.9	10.0	3.2	2.7	2.3	1.1	0.6
Pulse rate	2.6	4.4	10.6	-0.1	-1.4	-1.8	-3.3	-2.4
Neck or shoulder pain in last month	2.5	3.5	7.3	-1.7	-2.7	-2.1	-1.7	0.3
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.8	3.7	-1.9	-1.9	-1.7	-1.9	-0.2
Ever depressed for a whole week	2.3	2.8	4.7	1.7	1.5	2.0	2.2	0.2
Forced expiratory volume in 1-second (FEV1)	2.2	7.4	21.5	0.9	4.6	1.4	3.2	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.1	6.8	20.1	0.4	4.5	1.4	3.2	1.2
Blood White Count	1.9	13.8	22.4	-2.7	-2.8	-4.7	-4.1	-3.8
Pulse rate, automated reading	1.9	6.3	18.2	-0.3	-0.2	-1.9	-3.1	-4.3
Smoking status: Previous	1.9	2.8	6.5	-1.3	1.0	-0.1	2.2	2.5
Severe depression (siblings)	1.8	2.0	7.4	-2.7	0.7	-0.8	0.9	0.9
Current tobacco smoking	1.8	2.9	8.4	1.2	-2.9	0.5	-1.7	-1.2
Osteoporosis (self-reported)	1.8	2.3	6.0	-1.8	0.3	-1.4	0.1	2.4
Cholesterol lowering medication	1.8	2.6	5.4	-2.0	-1.6	-2.3	-0.2	-0.8
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	4.9	1.3	2.2	-0.7	0.8	1.3
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	4.5	0.8	1.1	2.0	2.1	0.2
Chronic bronchitis/emphysema (mother)	1.7	2.0	6.7	0.7	1.0	-0.0	-1.4	-2.6
Loneliness, isolation	1.7	2.4	6.4	2.2	2.5	-0.1	0.8	0.1
Financial situation satisfaction	1.7	2.2	4.6	1.7	0.5	2.1	0.6	1.7
Major Depression (MDD)	1.6	1.9	3.8	-0.7	1.9	1.1	1.8	1.1
Diabetes (father)	1.6	2.0	5.0	1.6	2.2	1.1	1.1	0.2
Townsend deprivation index at recruitment	1.6	2.2	4.8	0.5	1.3	2.2	2.1	0.4
Relative age voice broke	1.6	2.5	3.8	0.0	1.9	-1.5	-1.7	-1.9
Past tobacco smoking	1.6	2.9	8.4	1.4	0.3	-0.1	-2.1	-2.9
Loud music exposure frequency	1.6	1.7	4.7	1.5	2.2	0.9	0.7	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	6.5	-0.6	0.5	0.8	0.9	2.5
Smoking status: Current	1.6	2.6	8.2	1.0	-2.9	0.1	-1.6	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	9.1	-1.9	-0.3	-1.8	-3.0	-0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.5	3.5	10.4	-1.6	-0.4	-2.0	-3.2	-0.2
High cholesterol (Self-reported)	1.5	2.7	6.3	-1.3	-2.5	-1.3	-0.8	-1.8
Medication: Lisinopril	1.5	2.0	4.9	2.2	0.7	1.5	1.4	0.4
Leg fat percentage (left)	1.5	5.4	16.0	-0.9	-4.0	-1.5	-1.8	-2.2
Hand grip strength (right)	1.4	3.9	8.3	1.6	2.9	1.8	1.7	1.7
Family relationship satisfaction	1.4	1.8	4.8	1.3	0.2	2.2	1.2	0.8
Waist Hip Ratio (WHR)	1.3	5.7	9.6	-2.0	0.8	-2.6	-2.7	-3.1
Supplements: Zinc	1.3	1.4	3.1	-1.8	-0.1	-1.6	0.0	1.3
High blood pressure (mother)	1.3	1.8	4.4	1.6	-2.1	1.0	0.5	-1.1
Hair/balding pattern: Pattern 3	1.3	1.9	4.2	-1.5	-2.0	-0.7	-1.0	-1.4
Pulse wave reflection index	1.3	1.6	4.5	-0.6	-0.7	0.9	1.4	2.1
Medication: Amlodipine	1.3	1.9	3.0	1.7	-1.6	1.7	0.8	-0.5
Tinnitus: Yes, now most or all of the time	1.3	1.6	3.8	1.0	-1.7	0.6	1.9	0.2
Supplements: Fish oil (including cod liver oil)	1.3	1.7	3.4	1.0	1.8	0.9	1.7	0.8
Bipolar Disorder (2018)	1.2	2.0	6.6	-2.6	-0.1	-1.2	1.2	0.7
Ever had hysterectomy (womb removed)	1.2	1.4	2.6	-1.6	1.2	-1.0	1.3	0.1
Eye problems/disorders: Diabetes related eye disease	1.2	1.4	4.5	2.1	-1.1	0.1	-0.7	-0.8
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	5.1	1.6	-0.9	0.2	-1.0	-2.3
Blood clot in the leg (DVT)	1.2	1.5	3.3	1.4	0.7	0.8	1.8	1.1
Medication: Allopurinol	1.2	1.6	3.0	-1.6	-0.5	-1.7	-1.1	-1.0
Knee pain experienced in last month	1.2	1.8	5.4	1.0	-0.1	1.7	0.0	2.3
Back pain experienced in last month	1.2	1.7	4.7	0.9	0.7	0.5	2.2	1.6
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.5	1.4	-0.1	1.6	1.4	-0.8
Unable to work because of sickness or disability	1.2	1.5	3.9	1.3	1.0	2.0	-0.2	0.9
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	4.6	1.1	0.2	0.9	2.1	1.1
Heart disease (siblings)	1.2	1.5	2.9	-0.7	-1.2	0.7	1.7	1.6
Fasting Glucose	1.1	1.3	2.2	1.0	1.5	0.8	1.2	1.2
HDL Cholesterol	1.1	1.8	2.8	-0.6	-1.5	-1.7	-1.0	-1.7
Alcohol usually taken with meals	1.1	1.8	4.1	-0.4	-0.2	-2.0	-1.8	-1.3
Weight	1.1	5.3	15.4	0.6	2.2	1.6	3.9	1.8
Number of live births	1.1	1.5	3.9	-1.6	2.0	-0.8	0.6	-0.3
Birth weight of first child	1.1	2.1	10.0	0.3	3.2	-0.5	0.3	0.0
Gout (self-reported)	1.1	1.4	3.2	-1.8	-0.6	-1.4	-1.3	-0.4
Medication: Ventolin 100micrograms inhaler	1.1	1.5	3.7	1.6	0.2	1.9	0.2	1.0
Leg fat percentage (right)	1.1	4.0	12.4	-0.8	-3.5	-1.1	-1.3	-2.0
Medication: Ibuprofen	1.1	1.4	3.0	0.7	1.7	0.6	-0.2	1.7
Ever had bowel cancer screening	1.1	1.3	2.7	-1.4	-1.6	-0.7	0.0	1.2
Rheumatoid Arthritis	1.0	1.4	6.4	-0.8	2.5	0.2	0.3	-0.2
Schizophrenia (2014)	1.0	2.2	6.1	-1.1	1.7	0.1	2.5	0.9
Type 2 Diabetes (T2D) (2012)	1.0	1.2	3.0	-1.0	-1.7	-1.1	0.2	-0.8
Hand grip strength (left)	1.0	2.6	4.1	1.0	1.8	1.3	1.7	2.0
Sensitivity / hurt feelings	1.0	1.7	4.9	2.2	1.6	0.7	0.8	0.5
Hearing difficulty/problems: Yes	1.0	1.5	2.9	-1.7	-0.7	-1.7	0.9	-0.6
Maternal smoking around birth	1.0	1.5	4.8	1.1	2.2	0.8	-0.8	0.1
Multivitamins +/- minerals	1.0	1.3	4.6	-0.2	2.1	0.5	1.2	0.5
Chronic bronchitis/emphysema (father)	1.0	1.2	3.4	-1.1	-1.8	-1.0	-0.3	0.6
Medication: Simvastatin	1.0	1.5	3.3	-1.2	-1.8	-1.4	0.9	-0.3
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.2	3.1	0.5	1.3	1.0	0.3	1.8
Illnesses of mother	1.0	1.2	3.4	-1.1	1.8	-0.3	-0.6	1.1
Medication: Paracetamol	1.0	1.6	2.4	1.4	1.5	1.5	0.8	1.0
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	7.8	0.4	2.8	0.2	-0.1	0.6
Number of children fathered	1.0	1.1	2.8	-0.9	1.2	-0.5	-0.5	1.7
Medication: Omeprazole	1.0	1.1	3.0	0.5	-0.9	1.3	1.7	-0.2
Mood swings	1.0	1.8	5.5	1.6	2.4	0.4	0.4	-0.9
Breast cancer (self-reported)	1.0	1.2	2.5	-1.6	-1.0	-0.1	0.4	1.5
Hearing aid user	1.0	1.1	1.9	0.9	-1.4	1.2	0.9	0.8
Medication: Paracetamol	1.0	1.5	3.3	1.4	1.8	1.2	0.7	0.5
Medication: Atorvastatin	1.0	1.2	5.2	0.1	-2.3	0.2	-0.8	0.0
Alzheimer’s Disease (including proxy)	0.9	1.3	3.1	0.1	0.1	-1.7	-0.9	-1.8
Bipolar Disorder (2011)	0.9	0.8	1.8	-0.5	0.0	-1.0	1.4	1.0
Triglycerides	0.9	1.5	6.0	-0.5	-0.2	0.8	0.6	2.4
Heel T-Score	0.9	7.4	19.6	-1.4	-1.7	-3.3	-4.4	-1.4
Cardiovascular Disease	0.9	3.1	7.2	0.1	-2.7	-1.1	-1.3	-2.3
Medication: Co-codamol	0.9	1.1	3.2	0.5	1.8	0.8	-1.2	0.0
Taking other prescription medications	0.9	1.3	2.5	-1.2	-1.2	0.5	1.6	1.0
Impedance of leg (left)	0.9	4.3	10.7	-0.4	-1.0	-1.4	-3.3	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.3	-0.3	0.3	-1.2	-1.5	-1.2
Medication: Cholesterol lowering	0.9	1.4	5.0	-0.9	-2.2	-0.5	-0.3	-0.9
Length of working week for main job	0.9	1.0	3.5	-0.1	-0.7	-0.9	-1.9	0.2
Age at first live birth	0.9	1.6	3.4	-1.3	-1.9	-1.0	-0.5	1.3
Heart disease (mother)	0.9	1.1	1.9	1.2	-1.4	1.2	0.9	0.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	4.2	-0.0	-2.0	-0.7	-0.2	0.4
Handedness (chirality/laterality): Left-handed	0.9	1.1	2.1	-0.1	-1.4	-0.1	1.3	1.3
Commuting to job workplace: Walk	0.9	1.0	3.5	0.6	1.9	0.1	0.5	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.0	2.8	1.2	0.1	1.7	-0.6	0.6
Ever taken oral contraceptive pill	0.9	1.0	4.0	-0.2	2.0	0.8	0.4	0.6
Ever smoked	0.9	1.7	5.6	-1.3	-0.2	-0.2	1.0	2.4
Irritability	0.9	1.6	4.0	1.0	0.9	1.4	2.0	0.3
Bipolar Disorder or Schizophrenia	0.8	2.1	3.8	-1.6	1.1	-1.1	2.0	1.3
Depressed Affect (Nagel 2018)	0.8	1.7	4.4	2.1	1.7	0.4	1.0	-0.2
Ulcerative Colitis (UC)	0.8	1.5	4.8	-0.6	1.4	-0.5	-0.0	-2.2
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.8	1.7	-0.0	1.4	0.8	-0.6
Angina	0.8	1.1	3.3	-0.1	1.1	-1.8	-0.0	-0.9
Fed-up feelings	0.8	1.4	3.0	1.0	0.8	1.5	1.7	0.0
Supplements: Glucosamine	0.8	1.0	2.8	1.7	0.2	0.7	0.5	1.2
Fluid intelligence score	0.8	1.7	6.8	-2.6	0.3	-1.2	0.5	0.5
Hip circumference	0.8	3.5	9.2	1.7	1.1	1.8	3.0	1.1
Time employed in main current job	0.8	1.0	2.8	1.2	0.3	0.6	0.1	-1.7
Falls in the last year	0.8	1.1	3.1	-0.2	-1.1	-0.1	-1.8	-1.0
Prospective memory result	0.8	1.0	1.8	0.3	1.0	1.3	0.8	1.3
Medication for pain relief, constipation, heartburn	0.8	1.4	2.4	-0.9	-0.4	-1.6	-1.2	-1.4
Angina (self-reported)	0.8	1.0	2.9	0.0	1.1	-1.7	-0.0	-0.9
Overall health rating	0.8	1.7	3.1	1.5	-1.3	1.2	1.8	-0.2
Leg pain on walking	0.8	1.1	3.4	0.9	0.5	0.9	0.2	1.8
Mineral and other dietary supplements	0.8	1.1	3.7	-0.4	-1.9	0.0	-0.9	-1.0
Number of self-reported non-cancer illnesses	0.8	1.4	5.2	-0.4	-2.3	-0.6	0.9	0.6
Commuting to job workplace: Public transport	0.8	0.9	1.9	0.2	1.2	1.2	1.4	0.2
Commuting to job workplace: Cycle	0.8	1.0	3.6	0.0	1.9	0.6	-0.1	1.0
Alzheimer’s Disease (in mother)	0.7	0.9	3.4	-0.2	-0.4	-1.9	-0.6	-0.5
Irritable Bowel Disease (IBD)	0.7	1.6	4.9	0.1	1.4	-1.0	-0.4	-2.2
Primary Biliary Cirrhosis	0.7	0.9	3.7	-0.4	-0.1	1.9	0.9	-0.1
Number of treatments/medications taken	0.7	1.3	2.4	-0.1	-0.8	1.3	1.4	1.5
Diabetes (mother)	0.7	0.9	3.6	0.7	0.4	0.6	1.9	0.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.8	-0.5	1.2	-1.6	-1.7	0.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	2.3	1.5	-0.9	1.0	0.1	0.2
Medication: Levothyroxine sodium	0.7	1.1	4.3	-0.1	-0.6	0.2	-0.9	2.1
Had other major operations	0.7	0.8	1.7	-1.3	-0.0	-1.1	-0.5	-1.0
Mouth/teeth dental problems	0.7	1.0	1.5	1.0	0.8	1.2	-0.8	-1.2
Mouth/teeth dental problems: Dentures	0.7	1.3	4.8	-0.5	-2.2	-0.6	0.7	0.6
Peak expiratory flow (PEF)	0.7	1.6	4.5	-0.1	2.1	0.6	1.5	0.8
Body fat percentage	0.7	2.7	9.4	-0.5	-3.1	-0.9	-0.6	-1.6
Pulse wave peak to peak time	0.7	0.9	2.9	0.7	1.7	0.4	0.8	0.4
Mouth/teeth dental problems: Loose teeth	0.7	0.8	3.6	-0.5	-0.3	-1.9	-0.4	0.4
Age at last live birth	0.7	1.1	2.3	-1.5	-0.3	-0.2	1.1	1.2
Wears glasses or contact lenses	0.7	0.8	2.5	0.1	-0.0	0.8	1.6	1.0
Diastolic blood pressure, automated reading	0.7	2.0	6.2	0.2	-1.0	-1.1	-1.3	-2.5
Pain experienced in last month	0.7	1.2	3.1	-0.7	1.3	-0.8	-0.1	-1.8
Pack years of smoking	0.7	1.0	1.9	-0.7	-1.4	0.8	0.5	1.2
Impedance of whole body	0.7	3.5	7.7	-0.2	-0.8	-1.7	-2.8	-2.5
Schizophrenia (2018)	0.6	1.3	2.5	0.1	1.5	-0.5	1.6	1.1
Schizophrenia vs Biploar Disorder	0.6	0.7	1.8	0.5	1.3	0.9	0.9	-0.3
Mean Putamen Volume	0.6	0.7	3.0	-1.7	0.5	-0.2	-0.1	-0.2
Allergy or Eczema	0.6	1.5	3.5	-0.6	0.8	-1.9	-1.6	0.4
Relative age of first facial hair	0.6	1.2	3.0	-0.7	0.4	-1.7	-0.5	-1.5
Ever used hormone-replacement therapy (HRT)	0.6	0.7	2.7	-1.6	0.5	-0.1	0.2	0.7
Impedance of leg (right)	0.6	2.7	6.6	-0.4	-0.2	-0.9	-2.6	-2.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.5	1.1	-0.6	-0.0	-0.8	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	3.2	-1.8	-0.2	-0.0	-0.3	-0.2
Stomach or abdominal pain in last month	0.6	0.7	2.7	0.8	0.3	-0.1	0.2	1.6
Financial difficulties in last 2 years	0.6	0.8	1.7	1.3	1.0	-0.4	0.0	-1.0
Illnesses of siblings	0.6	0.9	1.8	1.4	0.4	1.2	-1.1	0.1
Arm fat percentage (right)	0.6	2.3	8.3	-0.3	-2.9	-0.8	-0.6	-1.5
Happiness	0.6	0.7	1.0	0.8	1.0	0.5	1.0	-0.7
Eye problems/disorders: None of the above	0.6	0.7	1.0	-0.9	0.0	-1.0	-0.9	-1.0
Medication: Blood pressure	0.6	1.0	4.6	0.2	-2.1	-0.0	0.2	0.7
Mean time to correctly identify matches	0.6	1.1	4.8	0.0	-2.2	0.3	0.6	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.8	0.3	-1.4	0.2	0.9	1.0
Supplements: Vitamin C	0.6	0.7	2.5	0.4	-0.6	0.3	-1.6	-0.6
Illnesses of siblings: Diabetes	0.6	0.8	1.6	-1.2	-0.9	-1.2	0.3	0.0
Arm fat percentage (left)	0.6	2.5	9.4	-0.2	-3.1	-0.7	-0.4	-1.5
Qualifications: nursing, teaching	0.6	0.9	2.1	0.6	-1.5	1.3	0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.3	0.8	1.1	1.1	1.5	-0.9
Average weekly beer plus cider intake	0.6	0.9	2.1	-0.9	1.1	-0.1	1.5	0.3
Medication: Omeprazole (e.g. Zanprol)	0.6	0.8	1.8	-0.2	-1.2	0.8	1.4	0.2
Neuroticism (Nagel 2018)	0.5	1.2	3.0	1.7	1.0	0.3	1.2	-0.4
Crohns Disease (2017)	0.5	1.1	2.9	0.7	0.8	-1.0	-0.7	-1.7
Breast Cancer	0.5	1.1	2.2	1.5	-0.4	1.4	1.0	0.0
LDL Cholesterol	0.5	0.8	1.5	0.5	-1.1	-0.9	0.3	1.2
Neuroticism (2016)	0.5	0.7	1.5	-0.7	1.2	-0.9	0.3	-0.9
Ulcerative Colitis	0.5	0.7	1.9	-0.5	1.0	-0.2	0.5	-1.4
BMI	0.5	2.8	9.0	-1.0	-3.0	-0.0	-0.2	-2.0
Chronotype (morning person)	0.5	1.3	4.5	0.6	-0.9	0.8	-0.1	2.1
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	1.0	1.0	1.0	0.6	0.3	1.0
Systolic blood pressure, automated reading	0.5	1.5	4.0	-0.3	-2.0	-0.9	-1.3	-1.0
Medication for hormone replacement therapy	0.5	0.5	1.5	-0.2	0.1	0.9	1.2	0.4
Pack years adult smoking proportion	0.5	0.7	1.1	-0.8	-1.0	0.8	0.7	0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.7	-0.8	-1.3	-0.8	0.2	-0.1
High blood pressure	0.5	1.3	6.2	0.1	-2.5	-0.3	0.2	-0.5
Medication: Atenolol	0.5	0.7	2.9	-0.1	1.7	-0.4	0.5	-0.4
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.5	0.3	1.2	-0.1	1.0	0.4
Glaucoma (self-reported)	0.5	0.6	1.3	-0.4	1.1	-0.4	-0.4	-1.1
Exposure to tobacco smoke outside home	0.5	0.6	1.3	1.1	-0.4	0.8	1.0	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.3	0.6	1.2	0.6	1.1	-0.2
Wheeze or whistling in the chest in last year	0.5	0.9	1.8	0.8	-0.5	-0.8	-1.4	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	-0.6	-0.6	-1.2	0.8	0.6
Migraine (self-reported)	0.5	0.7	2.8	0.3	0.6	1.7	0.3	0.0
Had major operations	0.5	0.6	1.4	0.7	-1.2	0.9	0.6	-0.5
Hypertension (Self-reported)	0.5	1.4	6.0	0.0	-2.4	-0.5	0.1	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	1.5	1.2	0.2	-0.5	0.6	-0.7
Average weekly red wine intake	0.5	0.8	2.1	-0.3	-0.3	-1.3	-1.4	-0.1
Medication: Bendroflumethiazide	0.5	0.8	1.7	-0.3	-0.0	1.1	1.3	1.0
Alcohol drinker status: Never	0.5	0.6	2.3	0.8	-1.5	-0.3	-0.3	-0.4
Myopia	0.5	0.7	1.4	-1.0	-0.8	1.2	0.4	0.3
Alcohol drinker status: Previous	0.5	0.5	1.9	-0.5	1.4	0.0	-0.1	-0.7
Depression (Nagel 2018)	0.4	0.6	1.7	1.3	-1.0	0.5	-0.2	0.0
Reaction Time	0.4	0.8	2.4	0.1	-1.6	0.6	0.9	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.9	-1.7	-0.2	-1.3	-0.0	-0.5
Prostate Cancer	0.4	0.5	2.0	-0.0	-0.2	1.4	0.4	-0.5
Age at First Birth	0.4	0.5	1.3	-0.8	-1.2	-0.8	0.2	-0.2
Respiratory disease	0.4	0.8	3.1	-0.3	-0.4	-0.8	-1.8	0.4
Lung FVC	0.4	2.0	4.8	0.5	2.2	1.0	1.5	1.3
Vitamin and mineral supplements	0.4	0.5	1.0	0.8	-0.8	0.4	1.0	0.5
Trunk fat percentage	0.4	1.8	6.6	-0.4	-2.6	-0.7	-0.1	-1.3
Body mass index (BMI)	0.4	1.5	6.6	-0.4	-2.6	-0.3	0.2	-0.9
Hearing difficulty/problems with background noise	0.4	0.6	1.3	-0.9	0.2	-1.1	-0.2	-0.9
Impedance of arm (right)	0.4	1.9	4.2	0.1	-0.2	-1.7	-2.0	-1.5
Alcohol intake versus 10 years previously	0.4	0.5	1.3	0.8	0.5	0.5	0.5	1.1
Father’s age at death	0.4	0.6	2.6	-0.6	0.1	-1.6	-0.2	-0.2
Depression (self-reported)	0.4	0.5	1.7	0.4	-0.0	0.8	1.3	-0.3
Impedance of arm (left)	0.4	1.8	3.6	0.1	-0.4	-1.5	-1.9	-1.7
Breastfed as a baby	0.4	0.5	1.7	-0.4	-0.3	-1.3	-0.3	0.7
Tense / ‘highly strung’	0.4	0.6	1.3	1.2	-0.4	0.4	1.1	0.5
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	-0.6	0.5	-1.0	-0.9	0.3
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.4	-1.1	-0.0	-0.6	-1.0	1.2
Birth weight	0.4	0.9	4.2	0.0	2.1	0.2	0.0	0.7
Medication: Seretide 50 evohaler	0.4	0.4	1.9	0.3	0.4	1.4	0.2	0.1
Alcohol intake frequency.	0.4	0.8	2.2	1.5	0.9	0.7	0.8	-0.0
Eye problems/disorders: Cataract	0.4	0.5	1.1	0.4	-0.2	-0.1	1.0	1.0
Mother’s age at death	0.4	0.5	0.8	-0.8	-0.1	-0.9	-0.6	0.9
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.0	0.0	-0.7	0.4	1.0	-0.8
Vascular/heart problems diagnosed by doctor	0.4	1.0	4.2	0.2	2.0	0.5	-0.6	0.6
Basal cell carcinoma (self-reported)	0.4	0.5	2.0	0.3	-0.4	-1.4	-0.1	0.0
Alzheimer’s Disease (in father)	0.3	0.4	1.0	0.6	1.0	0.2	-0.3	-0.6
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	0.6	0.1	0.9	0.4	0.8
Coronary Artery Disease (CAD)	0.3	0.3	1.3	-0.2	-1.1	-0.0	0.4	0.1
Crohns Disease (2012)	0.3	0.5	1.3	0.2	0.7	-1.2	-0.5	-0.7
HbA1C	0.3	0.3	0.9	-0.6	0.5	-1.0	-0.1	-0.4
Smoking Status	0.3	0.7	1.4	0.5	-1.2	0.5	0.5	1.2
Hypothyroidism (self reported)	0.3	0.6	2.0	-0.6	0.6	-0.4	-0.2	1.4
Neuroticism	0.3	0.7	1.4	0.9	0.3	-0.7	1.0	-1.2
Average weekly spirits intake	0.3	0.4	1.1	-0.8	-1.1	0.0	-0.2	0.4
Average weekly fortified wine intake	0.3	0.4	0.8	-0.9	-0.6	-0.8	-0.2	0.4
Qualifications: CSEs or equivalent	0.3	0.5	1.0	-0.5	-1.0	-0.4	-1.0	-0.0
Nervous feelings	0.3	0.6	1.8	-0.5	-0.8	-1.3	-0.2	-0.7
Had menopause	0.3	0.4	1.0	-1.0	-0.0	-0.4	0.2	-0.9
Diabetes (self-reported)	0.3	0.4	1.4	-0.3	0.1	-0.7	-0.2	-1.2
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.7	0.1	-0.4	-0.6	0.7	0.9
Neuroticism score	0.3	0.6	1.8	1.1	0.2	0.0	1.3	-0.1
Worrier / anxious feelings	0.3	0.5	1.1	1.1	-0.4	-0.4	0.9	0.3
Noisy workplace	0.3	0.4	0.8	0.7	-0.9	0.4	0.5	-0.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.7	-0.9	-0.2	-0.2	-0.0
Exposure to tobacco smoke at home	0.3	0.4	1.6	0.3	0.2	0.3	1.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.6	0.2	0.9	-0.3	1.3	0.1
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	-0.7	-0.4	-0.5	1.1	1.2
High blood pressure (siblings)	0.3	0.5	1.1	-0.3	-0.7	0.1	1.0	-0.8
Number of full brothers	0.3	0.4	0.8	-0.8	-0.2	-0.9	-0.7	-0.1
Health satisfaction	0.3	0.4	1.2	1.1	-0.7	0.4	-0.2	0.0
Shortness of breath walking on level ground	0.3	0.4	1.6	1.3	0.5	0.2	-0.3	-0.0
Emphysema/chronic bronchitis	0.3	0.4	1.0	0.1	-1.0	0.8	-0.4	-0.3
Chest pain or discomfort	0.3	0.5	1.4	0.5	-1.2	0.5	0.6	-0.5
Medication: Aspirin	0.3	0.3	1.0	0.4	-1.0	0.4	0.4	-0.6
Illnesses of father: Heart disease	0.3	0.4	1.2	0.4	-1.1	-0.5	0.1	-0.4
Long-standing illness, disability or infirmity	0.3	0.4	1.1	0.9	-1.0	0.5	0.3	0.1
Friendships satisfaction	0.3	0.4	0.9	0.2	0.6	0.5	0.7	0.9
Medication for cholesterol	0.3	0.5	1.3	1.2	0.7	0.7	-0.1	0.4
Illnesses of father: None of the above (group 1)	0.3	0.4	0.7	0.2	0.9	0.6	-0.7	-0.7
Average weekly champagne plus white wine intake	0.3	0.5	0.9	-0.6	0.3	-1.0	-0.3	-0.9
Number of operations (self-reported)	0.3	0.5	1.2	0.1	-0.5	-0.7	-1.1	-0.6
Risk taking	0.3	0.4	1.2	0.3	-0.6	1.1	-0.3	0.5
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.1	0.0	0.6	-1.0	0.8
Age started oral contraceptive pill	0.3	0.4	1.5	-0.5	-0.1	-0.1	-0.5	1.2
Worry (Nagel 2018)	0.2	0.4	0.9	0.0	-0.7	-0.5	0.7	-0.9
Ovarian Cancer	0.2	0.3	0.6	0.4	-0.8	-0.2	0.5	-0.5
Lupus	0.2	0.3	1.1	0.3	-0.6	1.1	-0.3	0.1
Blood Eosinophil Count	0.2	1.9	3.4	-0.1	-1.7	-0.8	-1.8	-1.5
Blood Platelet Count	0.2	2.8	7.1	0.3	0.7	2.3	2.7	1.0
Blood Red Count	0.2	2.0	4.9	-0.5	-2.2	-1.6	-0.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.3	1.1	0.2	-0.1	0.5	0.3
Lung FEV1/FVC ratio	0.2	1.0	2.6	0.2	-1.6	-0.3	1.4	-0.7
Tanning	0.2	1.9	5.9	2.4	0.4	1.9	-0.2	0.1
Trunk fat mass	0.2	0.7	3.0	0.2	-0.4	0.3	1.7	-0.0
Number of incorrect matches in round	0.2	0.4	0.9	0.9	0.2	1.0	0.1	0.0
Hair/balding pattern: Pattern 2	0.2	0.2	0.9	-1.0	0.1	0.3	0.4	-0.3
Heart attack	0.2	0.2	0.4	0.4	0.4	0.2	0.6	-0.5
Allergy	0.2	0.5	1.0	-0.3	-1.0	0.4	0.7	-0.7
Pain all over the body in last month	0.2	0.3	0.7	-0.4	0.2	-0.9	-0.3	-0.5
Medication: Ramipril	0.2	0.3	1.0	-0.4	-1.0	0.2	0.3	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.1	1.1	-0.2	0.1	0.3	-0.6
Medication: Lansoprazole	0.2	0.3	0.9	0.0	0.1	0.0	0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.0	-0.1	0.2	-0.4	-1.0	0.3
Worry too long after embarrassment	0.2	0.3	0.6	0.3	-0.8	0.2	0.8	0.0
Qualifications: College or University degree	0.2	0.5	1.3	-0.4	-0.9	-0.4	-0.0	-1.2
Whole body fat mass	0.2	0.7	3.2	-0.0	-0.4	0.4	1.8	0.1
Suffer from ‘nerves’	0.2	0.4	1.0	0.3	1.0	0.5	0.5	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.5	-0.1	0.1	0.5	1.2	-0.4
Medication: Aspirin	0.2	0.2	0.7	0.5	-0.3	0.0	0.1	-0.8
Medication: Gliclazide	0.2	0.3	0.7	-0.0	0.2	-0.8	-0.7	0.3
Arm fat mass (left)	0.2	0.7	2.9	0.3	-0.5	0.5	1.7	0.2
Guilty feelings	0.2	0.3	1.1	0.2	1.1	0.0	0.6	0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	0.1	0.6	-0.6	-0.7	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.8	-0.6	-0.4	-0.9	0.0	0.0
Supplements: Calcium	0.2	0.2	0.6	0.3	-0.1	0.5	-0.5	0.8
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.6	-0.6	-0.5	-0.8	0.4	0.1
Systolic Blood Pressure	0.1	0.7	2.6	0.4	-1.6	-0.6	-0.7	-0.3
Medication: Metformin	0.1	0.2	0.3	0.5	0.2	0.3	-0.4	-0.6
Waist circumference	0.1	0.4	0.9	-0.3	-0.5	-0.2	0.9	-0.9
Qualifications: None of the above	0.1	0.1	0.3	0.2	-0.2	-0.5	0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.3	-0.3	0.4	-0.6	-0.4	0.5
Asthma	0.1	0.2	0.9	0.3	-0.1	0.2	0.3	1.0
Lung cancer (father)	0.1	0.2	0.5	0.3	0.2	0.7	-0.1	0.2
Arm fat mass (right)	0.1	0.5	2.1	-0.0	-0.4	0.3	1.4	0.1
Comparative body size at age 10	0.1	0.4	1.0	0.6	-0.3	-0.6	-1.0	0.3
Leg fat mass (right)	0.1	0.5	1.8	0.0	-0.7	0.5	1.4	-0.0
Number of full sisters	0.1	0.2	0.4	0.2	-0.2	-0.7	0.5	0.3
Asthma (self-reported)	0.1	0.2	0.6	0.4	0.1	0.0	-0.1	0.8
Osteoarthritis (self-reported)	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.2	0.3
Miserableness	0.1	0.2	0.5	0.4	-0.1	0.7	0.7	-0.0
Medication: Blood pressure	0.1	0.2	0.4	-0.6	-0.6	-0.2	0.6	-0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.5	0.3	0.3	0.1	0.3	-0.7
Leg fat mass (left)	0.1	0.4	1.0	0.0	-1.0	0.2	1.0	-0.1
Hair Pigment	0.0	0.5	2.3	0.4	-1.5	-0.1	-0.1	0.2
Diabetes diagnosed by doctor	0.0	0.1	0.2	0.2	0.1	-0.5	0.2	-0.1

Hub : Genes

TNFSF10

Models

Trait associations