Hub : Genes

FNDC3B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0730 0.0270 4.8e-03 0.060 0.018 0.054 0.020 0.000 8.0e-08 2.6e-03 3.2e-07 1.3e-03 3.1e-01
2 METSIM Adipose 0.0941 0.0261 6.2e-06 0.078 0.021 0.066 0.062 0.073 8.2e-12 3.2e-04 3.4e-10 1.5e-09 5.0e-11
3 YFS Blood 0.0559 0.0165 2.2e-05 0.000 0.016 0.016 0.018 0.002 3.7e-01 3.1e-06 3.8e-06 1.4e-06 5.8e-02
4 TCGA Glioblastoma Multiforme 0.2680 0.1000 6.3e-03 0.050 0.024 0.072 NA 0.082 1.3e-02 6.1e-02 3.3e-03 NA 1.8e-03
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0723 0.0318 5.1e-03 0.023 0.011 0.018 NA 0.017 1.2e-03 1.6e-02 3.9e-03 NA 4.5e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.3 0.5 0.8 0.9 -0.5 0.6 -0.8 -0.6
Bipolar Disorder or Schizophrenia 0.1 0.2 0.8 0.2 -0.2 0.2 -0.4 -0.9
Depressed Affect (Nagel 2018) 0.6 1.3 3.6 1.0 -1.0 -0.7 1.9 0.5
Depression (Nagel 2018) 0.4 0.6 1.8 -0.8 -0.6 0.1 1.3 -0.3
Intelligence (Savage-Jansen 2018) 0.7 2.1 7.8 2.8 1.6 -0.2 -0.0 0.1
Neuroticism (Nagel 2018) 0.8 1.8 7.2 0.3 -0.1 -0.7 2.7 1.1
Schizophrenia (2018) 0.1 0.2 0.4 -0.5 0.1 -0.2 0.2 -0.6
Schizophrenia vs Biploar Disorder 1.6 2.1 7.2 -2.7 1.1 -0.9 0.0 -1.3
Worry (Nagel 2018) 1.2 2.6 8.4 -0.4 0.6 -0.4 2.9 2.0
Alzheimer’s Disease (in mother) 0.2 0.2 0.7 -0.5 -0.3 0.9 0.2 -0.1
Alzheimer’s Disease (in father) 1.7 1.9 5.7 0.4 0.4 -2.4 1.8 0.2
Alzheimer’s Disease (including proxy) 0.5 0.7 2.4 -0.2 0.1 -1.5 1.1 0.1
Crohns Disease (2017) 0.7 1.6 4.5 1.6 -0.4 -0.1 1.0 2.1
Irritable Bowel Disease (IBD) 1.0 2.3 8.9 1.5 -0.1 -0.0 0.5 3.0
Ulcerative Colitis (UC) 1.1 2.2 9.6 1.0 -0.0 0.4 0.0 3.1
Major Depression (MDD) 0.7 0.8 2.6 -0.1 0.1 -1.2 -0.3 -1.6
Reaction Time 0.8 1.6 4.8 -2.2 1.7 0.2 0.3 0.3
Verbal and Numeric Reasoning (VNR) 0.4 1.0 2.7 1.6 0.7 -0.7 1.1 0.5
Breast Cancer 0.8 2.0 5.6 0.2 -0.3 -0.6 1.9 2.4
Ovarian Cancer 1.2 1.5 2.6 1.0 -1.6 -1.3 -1.2 1.0
Prostate Cancer 0.7 1.0 2.8 -0.8 0.8 0.1 -1.7 -0.9
Age at First Birth 0.9 1.3 5.0 -0.2 2.2 0.2 1.2 -0.0
Bipolar Disorder (2011) 0.9 0.9 2.7 1.3 -0.4 -1.6 0.0 -0.0
Body Mass Index (BMI) (2010) 1.4 1.9 4.4 -0.4 -0.2 2.1 -1.7 -1.3
Coronary Artery Disease (CAD) 0.1 0.2 0.4 0.5 -0.6 -0.3 -0.1 0.1
Crohns Disease (2012) 0.6 1.0 2.8 1.7 -0.9 -0.3 0.7 0.8
Mean Putamen Volume 0.7 0.8 2.1 0.1 0.1 1.4 -1.1 1.0
Fasting Glucose 0.4 0.5 1.6 -0.3 0.0 0.8 -0.6 -1.3
HbA1C 1.9 2.2 5.2 0.7 0.5 0.3 -2.2 -2.3
HDL Cholesterol 1.4 2.3 6.2 -1.8 0.7 -0.1 1.4 2.5
LDL Cholesterol 0.2 0.3 0.6 0.2 -0.7 -0.7 0.6 -0.3
Lupus 0.5 0.8 2.8 1.7 -0.4 -0.9 0.4 -0.3
Neuroticism (2016) 0.7 1.0 2.2 -1.5 0.2 -0.6 0.5 -1.4
Primary Biliary Cirrhosis 0.7 1.0 2.4 -0.1 -0.4 -0.7 -1.5 -1.3
Rheumatoid Arthritis 0.7 1.0 3.4 0.1 0.2 -0.2 -1.2 -1.8
Schizophrenia (2014) 0.4 1.0 3.2 -1.1 0.4 0.1 -0.3 -1.8
Triglycerides 1.3 2.1 3.6 0.9 -1.9 1.4 -1.4 -1.3
Type 2 Diabetes (T2D) (2012) 0.5 0.6 2.1 0.0 -1.4 -0.4 0.8 0.5
Ulcerative Colitis 1.0 1.5 6.5 0.7 -0.2 -0.1 0.5 2.5
Blood Eosinophil Count 0.4 2.9 4.7 -1.2 2.0 1.9 0.9 2.2
Blood Platelet Count 0.3 3.8 11.0 -2.0 2.0 -3.3 -0.4 -0.1
Blood Red Count 0.1 0.9 2.7 -1.6 -0.5 1.2 -0.2 0.7
Blood White Count 1.4 10.1 29.3 -3.2 -0.5 -1.4 3.0 5.4
Heel T-Score 0.4 3.5 6.9 1.6 -1.0 1.8 1.9 2.6
BMI 0.4 2.1 5.9 -0.7 -2.4 -0.6 1.3 1.4
Height 7.9 152.9 408.0 20.2 -4.6 -3.8 -10.4 -14.6
Waist Hip Ratio (WHR) 2.1 9.6 16.2 3.1 -2.1 -1.9 3.8 4.0
Systolic Blood Pressure 0.9 4.4 11.0 1.1 -3.3 -1.4 1.8 2.1
Smoking Status 0.8 1.8 4.5 1.0 -2.1 1.7 -0.7 -0.4
Allergy or Eczema 0.9 2.4 7.9 -0.5 1.3 2.8 0.7 1.2
Cardiovascular Disease 1.2 3.9 8.2 -1.3 -2.4 -0.9 1.8 2.9
Hypothyroidism (self reported) 0.3 0.7 2.2 1.5 0.7 -0.1 -0.4 -0.9
Respiratory disease 0.2 0.5 1.1 1.1 -0.2 -1.1 -0.3 0.5
Type 2 Diabetes (T2D) (2018) 1.3 2.4 8.3 -0.2 -0.1 -2.9 1.4 1.2
Lung FEV1/FVC ratio 0.5 2.5 4.9 -2.0 0.5 -0.5 -2.2 1.7
Lung FVC 0.9 4.4 10.9 -3.3 0.8 -0.3 -1.5 -2.9
Neuroticism 0.9 2.1 7.7 -0.1 0.2 -0.8 2.8 1.4
Chronotype (morning person) 0.3 0.7 1.6 -1.0 -0.4 1.3 -0.1 0.8
Hair Pigment 0.0 0.5 1.0 0.6 -0.4 1.0 0.3 0.9
Tanning 0.1 0.6 1.5 -1.2 1.1 0.6 0.2 -0.1
Hand grip strength (left) 1.6 4.3 13.0 3.6 -1.8 -0.2 -1.0 -2.1
Number of treatments/medications taken 0.3 0.5 1.0 -0.8 1.0 0.4 0.7 0.5
Average weekly spirits intake 0.4 0.5 1.2 -0.7 -0.0 1.1 0.4 -0.6
Sensitivity / hurt feelings 0.9 1.6 3.6 -0.8 1.2 -1.1 1.9 1.0
Frequency of depressed mood in last 2 weeks 0.4 0.6 1.5 -0.7 -0.1 -0.5 1.2 -0.8
Hearing difficulty/problems: Yes 0.6 0.9 3.4 0.8 1.9 -0.8 0.2 0.0
Relative age of first facial hair 1.6 3.4 6.2 1.3 1.6 -0.3 2.5 2.5
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.2 -0.4 0.5 -0.8 1.1 0.2
Ever used hormone-replacement therapy (HRT) 1.2 1.6 5.0 -0.4 0.2 2.2 0.6 -1.5
Ever had hysterectomy (womb removed) 0.5 0.5 1.2 -0.6 -1.1 0.2 -0.9 -0.5
Systolic blood pressure, automated reading 1.0 2.9 5.6 1.0 -1.5 -2.4 1.4 1.9
Eye problems/disorders: Diabetes related eye disease 1.5 1.7 3.1 -0.2 1.7 -0.9 1.8 1.2
Angina 0.6 0.8 2.9 -0.1 0.5 -0.0 1.0 1.7
Medication for hormone replacement therapy 0.6 0.7 2.8 -0.2 -0.1 -0.7 -0.1 -1.7
Vitamin and mineral supplements 1.0 1.3 3.5 1.9 -0.9 -0.8 0.6 1.1
Supplements: Zinc 0.8 0.9 2.2 1.4 1.5 -0.3 -0.4 -0.2
Medication: Co-codamol 0.9 1.0 2.0 -0.3 -1.0 -0.4 -1.4 -1.3
Medication: Metformin 1.3 1.9 5.7 -0.1 0.1 -2.4 0.7 1.8
Diabetes (father) 0.9 1.1 3.6 0.1 -0.8 0.3 -1.9 -1.1
Diabetes (mother) 1.0 1.3 2.8 1.5 0.7 0.1 -1.7 -0.8
Severe depression (siblings) 1.5 1.7 5.7 -0.1 -0.5 -0.1 -1.5 -2.4
Pack years adult smoking proportion 0.2 0.3 0.9 0.3 0.1 0.1 1.0 0.5
Impedance of leg (right) 0.6 2.9 8.0 -0.4 2.8 -1.7 -0.0 1.9
Leg fat-free mass (left) 4.7 24.8 58.1 7.6 -4.3 -1.4 -3.3 -5.9
Trunk fat percentage 0.6 2.4 4.6 2.2 -0.8 -1.7 1.2 1.5
Hand grip strength (right) 2.4 6.6 16.6 4.1 -2.6 -1.4 -1.3 -2.4
Townsend deprivation index at recruitment 1.7 2.4 3.4 0.9 1.2 -1.8 -1.7 -1.8
Current tobacco smoking 1.1 1.7 2.7 1.6 -0.2 1.4 1.4 1.5
Average weekly fortified wine intake 0.5 0.6 2.4 -0.5 1.5 0.1 0.2 -0.5
Maternal smoking around birth 1.0 1.4 4.2 2.1 -0.1 1.7 0.2 -0.0
Fed-up feelings 0.2 0.3 0.9 -0.3 -0.3 -1.0 0.6 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.1 2.0 -1.4 -1.2 -0.0 1.4 -0.4
Relative age voice broke 1.1 1.6 4.0 1.3 0.7 -0.3 1.4 2.0
Taking other prescription medications 0.2 0.3 0.7 0.4 0.3 -0.9 0.6 -0.0
Age when periods started (menarche) 2.7 6.5 18.0 -0.8 -0.8 -0.4 4.2 3.6
Bilateral oophorectomy (both ovaries removed) 1.4 1.6 4.4 -2.1 0.1 1.9 -0.4 0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.2 1.6 1.3 -1.2 1.0 1.2 0.8
Tinnitus: Yes, but not now, but have in the past 0.8 0.8 2.9 -0.8 0.2 -0.1 1.7 -0.7
Qualifications: CSEs or equivalent 1.0 1.3 2.6 -0.7 -1.1 1.1 1.1 1.6
Serious illness, injury or assault to yourself 0.8 1.0 2.1 -0.4 0.6 -0.7 1.5 1.3
High blood pressure 0.5 1.5 4.7 -0.2 -1.3 -0.3 1.1 2.2
Hayfever, allergic rhinitis or eczema 0.7 1.5 2.9 -0.1 1.3 1.7 1.4 0.8
Multivitamins +/- minerals 1.6 2.1 6.6 -1.0 1.1 -0.2 -1.2 -2.6
Stomach or abdominal pain in last month 0.6 0.7 3.2 0.2 0.0 1.8 0.6 0.3
Supplements: Glucosamine 1.7 2.2 4.9 -1.1 -1.3 2.2 -1.0 -1.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.5 -0.9 1.2 -0.5 0.6 1.0
Medication: Atenolol 0.0 0.0 0.1 -0.0 -0.1 -0.0 0.2 -0.2
Medication: Levothyroxine sodium 0.4 0.7 1.9 0.4 0.8 0.4 1.4 0.8
Sitting height 5.1 35.9 75.0 8.7 -2.1 -3.3 -5.0 -8.0
Chronic bronchitis/emphysema (father) 0.6 0.7 1.0 0.8 -1.0 0.5 0.6 1.0
High blood pressure (mother) 2.3 3.2 7.3 -0.4 -1.0 -1.9 2.0 2.7
Body mass index (BMI) 0.3 1.1 3.9 0.3 -2.0 -0.4 1.0 0.6
Impedance of leg (left) 0.6 3.1 8.5 -0.6 2.9 -1.2 0.6 2.3
Leg predicted mass (left) 4.7 24.9 57.3 7.6 -4.4 -1.5 -3.3 -5.9
Trunk fat mass 1.4 6.0 19.4 4.4 -2.1 -2.3 -0.2 -0.7
Waist circumference 1.4 5.1 12.6 3.5 -2.7 -2.0 1.3 0.6
Number of incorrect matches in round 0.2 0.3 0.8 -0.8 -0.5 0.2 -0.1 -0.9
Past tobacco smoking 1.1 2.1 4.5 -1.1 2.1 -1.1 1.1 1.5
Alcohol usually taken with meals 1.0 1.6 5.0 -2.2 0.3 -1.0 0.6 1.3
Nervous feelings 0.4 0.7 2.6 -0.7 0.3 0.1 1.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.7 -0.9 0.2 0.1 1.7 0.5
Hearing difficulty/problems with background noise 0.3 0.5 1.4 0.3 0.7 -0.3 1.2 0.6
Hair/balding pattern: Pattern 2 0.7 0.9 3.5 -0.1 -1.9 -0.6 -0.9 -0.1
Had menopause 1.5 1.9 5.1 -1.3 -1.1 0.4 -1.2 -2.2
Had other major operations 0.7 0.8 2.5 -1.6 0.0 0.9 -1.0 0.1
Forced vital capacity (FVC) 3.5 13.3 33.4 2.6 -1.7 -1.7 -4.5 -5.8
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.3 0.8 -0.9 1.5 2.1 1.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.9 2.4 -0.4 1.5 -0.3 1.4 0.3
Qualifications: None of the above 0.4 0.9 3.0 0.5 -1.7 0.3 0.9 0.6
Financial difficulties in last 2 years 0.4 0.6 1.1 1.1 -0.5 -0.7 0.7 0.7
Mouth/teeth dental problems 0.8 1.3 4.2 -0.1 2.1 0.8 0.5 1.1
Heart attack 0.4 0.5 1.3 0.0 -1.0 -0.3 1.2 0.4
Allergy 0.4 0.9 1.4 -0.7 -1.0 -1.2 -1.2 -0.6
Pain all over the body in last month 0.8 0.9 1.8 -1.0 -0.7 -1.3 1.1 -0.2
Diabetes (self-reported) 1.9 3.0 13.1 0.5 0.5 -3.6 0.5 1.0
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 3.0 0.5 0.5 0.7 1.7 1.3
Medication: Ramipril 0.9 1.2 4.0 -0.2 -0.9 -0.7 2.0 0.7
Medication: Simvastatin 1.0 1.5 4.3 -1.1 0.3 -2.1 0.8 1.0
Fluid intelligence score 0.3 0.6 1.7 -0.2 1.3 -1.2 0.3 -0.2
Illnesses of siblings 1.6 2.2 3.2 1.8 -0.5 1.4 -1.6 -1.7
Neuroticism score 0.8 1.6 6.3 0.1 -0.1 -0.7 2.5 1.2
Weight 3.1 15.4 42.2 6.5 -3.6 -2.1 -1.9 -3.7
Impedance of arm (right) 0.9 4.4 8.8 -0.7 2.9 -0.6 2.0 3.0
Arm fat percentage (right) 0.6 2.4 5.6 0.2 -1.3 -1.0 1.9 2.4
Trunk fat-free mass 7.7 44.3 86.9 9.3 -5.2 -1.3 -5.7 -8.6
Hip circumference 1.6 6.7 20.3 4.5 -1.7 -2.2 -0.9 -2.1
Time employed in main current job 0.6 0.7 2.3 -0.6 0.4 -0.5 1.5 0.7
Alcohol intake versus 10 years previously 1.7 2.6 8.8 3.0 1.0 0.3 -1.3 -1.2
Father’s age at death 2.3 3.1 5.7 -1.4 2.4 -0.8 -2.1 -1.7
Worrier / anxious feelings 1.4 2.7 8.4 0.0 1.0 -0.4 2.9 2.0
Frequency of tiredness / lethargy in last 2 weeks 1.0 1.6 2.7 -0.6 0.8 -1.6 1.6 1.4
Falls in the last year 0.5 0.7 1.5 -0.5 1.2 -0.4 1.2 0.4
Hair/balding pattern: Pattern 3 2.6 3.8 10.7 0.2 2.0 0.9 3.3 1.9
Number of live births 0.5 0.7 1.4 -0.9 -1.2 0.9 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1) 3.2 10.9 24.3 1.2 -1.6 -1.9 -4.9 -4.8
Pulse rate 2.3 4.0 11.2 0.9 0.0 -1.1 2.5 3.3
Happiness 1.9 2.3 7.0 -0.7 -0.7 -0.1 2.6 1.8
Noisy workplace 0.5 0.6 1.9 -0.2 -0.8 1.4 0.8 0.1
Qualifications: A levels/AS levels or equivalent 1.2 2.7 12.0 -0.3 3.5 -0.2 -0.0 1.3
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.3 0.5 0.7 1.5 0.8 0.3
Mouth/teeth dental problems: Dentures 0.6 1.0 4.0 -0.3 -2.0 0.4 0.4 -0.8
Asthma 0.6 1.1 1.6 1.2 1.1 -0.8 1.0 1.1
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.6 3.3 -0.3 1.8 -1.1 -1.3 -1.3
Medication: Cholesterol lowering 0.8 1.3 2.9 0.4 -0.5 -1.4 1.7 1.1
Depression (self-reported) 0.6 0.8 1.9 -0.3 1.3 -1.4 -0.2 -0.2
Medication: Lansoprazole 2.6 3.0 10.6 -3.3 -0.6 -1.1 0.4 -1.6
Prospective memory result 1.8 2.2 4.1 2.0 0.8 -0.6 -1.5 -1.8
Lung cancer (father) 0.8 1.0 2.8 0.2 0.0 0.6 -1.7 -1.3
Illnesses of mother 1.2 1.4 2.7 -0.9 0.4 1.0 -1.5 -1.7
Forced expiratory volume in 1-second (FEV1), Best measure 3.0 9.4 22.9 0.8 -1.6 -1.5 -4.3 -4.8
Pulse wave Arterial Stiffness index 0.4 0.4 0.9 -0.9 -0.9 0.3 0.4 -0.5
Impedance of arm (left) 0.9 4.3 10.0 -0.3 2.7 -0.6 2.0 3.2
Arm fat mass (right) 0.8 3.2 7.8 2.8 -2.4 -1.5 0.0 -0.5
Trunk predicted mass 7.6 43.5 82.8 9.1 -5.1 -1.3 -5.8 -8.6
Standing height 7.4 73.0 190.4 13.8 -3.8 -3.6 -6.7 -10.1
Length of working week for main job 0.0 0.0 0.0 0.1 -0.1 -0.2 -0.1 0.0
Exposure to tobacco smoke at home 1.5 1.7 4.5 2.1 -0.4 0.7 -1.0 -1.5
Breastfed as a baby 0.6 0.8 2.6 -0.9 -0.7 0.2 -1.6 -0.0
Tense / ‘highly strung’ 0.4 0.7 1.8 0.5 -1.0 -0.4 1.4 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.6 0.5 -1.2 -1.0 1.6 0.9
Hair/balding pattern: Pattern 4 0.8 2.0 4.6 -0.3 -2.2 0.6 -1.9 -1.2
Birth weight of first child 1.0 1.8 6.2 2.5 1.4 0.3 -0.7 -0.8
Peak expiratory flow (PEF) 2.1 4.8 8.0 0.8 -2.4 -1.4 -2.7 -2.8
Pulse wave reflection index 1.8 2.3 6.0 -1.1 0.6 1.3 -1.4 -2.4
Ever highly irritable/argumentative for 2 days 0.6 0.7 1.8 -1.3 1.1 0.1 -0.2 -0.8
Loud music exposure frequency 0.9 1.0 1.5 -1.2 -0.7 1.1 -0.4 -1.2
Qualifications: O levels/GCSEs or equivalent 0.3 0.5 1.5 -0.4 1.2 -0.0 -0.2 0.8
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 5.3 -0.3 -2.3 -0.5 -1.4 -1.0
Blood clot in the leg (DVT) 1.2 1.5 2.7 1.6 -1.3 0.2 -1.1 -1.5
Medication: Paracetamol 0.2 0.3 0.5 0.7 0.6 -0.5 -0.5 -0.3
Headache pain in last month 0.9 1.5 3.7 0.2 1.8 0.0 -0.8 -1.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.7 -0.3 -0.3 0.2 -0.7 -0.9
Glaucoma (self-reported) 2.7 3.1 5.3 -1.7 1.8 1.8 2.3 0.8
Gout (self-reported) 0.2 0.3 1.0 0.5 0.2 -1.0 -0.3 -0.0
Hypothyroidism/myxoedema (self-reported) 0.4 0.7 2.0 1.2 1.4 0.0 0.2 -0.0
Medication: Amlodipine 0.9 1.3 3.8 -1.9 -0.6 1.2 -0.8 0.4
Medication: Ventolin 100micrograms inhaler 1.2 1.6 6.7 2.6 0.5 0.0 -0.9 -0.4
Birth weight 0.9 2.0 7.6 2.8 -0.8 0.5 -0.1 -1.3
Chronic bronchitis/emphysema (mother) 1.1 1.3 3.2 0.5 0.8 0.7 1.3 1.8
High blood pressure (siblings) 1.4 2.0 3.6 -1.9 0.1 -0.9 1.6 1.8
Forced vital capacity (FVC), Best measure 3.6 13.0 34.0 2.7 -1.6 -1.5 -4.3 -5.8
Body fat percentage 0.6 2.4 4.1 1.6 -0.9 -1.6 1.4 2.0
Leg fat percentage (right) 0.6 2.3 5.7 0.9 -0.5 -1.8 1.3 2.4
Arm fat-free mass (right) 6.6 33.8 66.6 8.2 -4.6 -1.2 -5.0 -7.4
Exposure to tobacco smoke outside home 0.9 1.3 3.6 -0.8 0.7 -1.2 -0.3 -1.9
Comparative body size at age 10 0.8 2.2 7.0 -0.5 -2.6 1.2 -0.4 -1.5
Number of full brothers 1.1 1.4 2.6 -0.7 0.2 1.4 -1.6 -1.4
Worry too long after embarrassment 0.4 0.7 2.7 0.0 0.2 0.9 1.6 -0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 5.6 -1.0 -0.2 0.7 -1.4 -2.4
Wheeze or whistling in the chest in last year 0.2 0.4 1.2 0.1 0.6 -0.2 0.4 1.1
Number of children fathered 0.6 0.7 1.7 1.3 0.2 0.6 -0.7 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.2 0.4 0.1 0.4 0.3 -0.7 0.6
Age at first live birth 0.3 0.5 0.6 -0.2 0.8 0.7 -0.7 -0.7
Pulse wave peak to peak time 0.8 1.0 3.6 1.9 0.5 -0.5 -0.8 -0.3
Health satisfaction 1.8 2.3 4.7 -1.1 1.0 0.8 2.2 2.0
Shortness of breath walking on level ground 0.8 0.9 2.1 -0.3 -0.8 1.4 0.7 1.2
Qualifications: College or University degree 0.3 1.0 1.8 -0.0 1.3 -0.0 -1.4 -1.2
Eye problems/disorders: None of the above 2.3 2.6 7.7 -0.3 -1.3 -1.7 -2.8 -0.9
Mouth/teeth dental problems: Loose teeth 0.6 0.8 2.3 0.4 -1.5 -0.3 -0.7 -0.8
Emphysema/chronic bronchitis 0.7 0.8 2.2 -0.7 0.9 -1.5 -0.5 0.6
Medication for pain relief, constipation, heartburn 0.1 0.1 0.4 -0.3 -0.6 0.3 0.1 -0.1
Neck or shoulder pain in last month 0.3 0.4 1.8 -0.2 0.3 0.3 0.3 1.3
Medication: Blood pressure 0.3 0.5 2.2 -0.1 -0.0 1.5 -0.1 0.5
Angina (self-reported) 0.6 0.8 3.0 -0.1 0.4 0.2 0.9 1.7
Migraine (self-reported) 0.9 1.1 2.8 1.2 -0.8 -0.2 -0.7 -1.7
Medication: Ibuprofen 1.2 1.5 4.2 0.2 2.1 -0.4 -1.1 -1.3
Medication: Allopurinol 1.3 1.8 4.8 1.2 -0.5 -2.2 0.9 1.3
Medication: Omeprazole 1.0 1.2 3.5 -0.8 0.5 -1.9 -1.2 -0.5
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.3 -0.5 -0.1 -0.4 -0.4
Mean time to correctly identify matches 0.8 1.6 4.0 -2.0 1.6 -0.3 0.7 0.9
Heart disease (mother) 0.4 0.5 1.8 1.3 0.4 -0.8 -0.0 0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.0 3.6 11.0 -0.8 1.2 0.6 2.1 3.3
Whole body fat mass 1.3 5.4 17.0 4.1 -2.2 -2.2 -0.3 -0.7
Leg fat mass (right) 1.2 4.5 12.7 3.6 -2.2 -2.1 -0.5 -0.6
Arm predicted mass (right) 6.8 34.6 68.6 8.3 -4.8 -1.4 -5.0 -7.4
Pulse rate, automated reading 4.5 14.5 30.0 2.2 -1.3 -2.5 5.5 5.5
Alcohol intake frequency. 0.4 1.0 3.7 0.8 0.8 -1.9 0.1 0.5
Comparative height size at age 10 10.5 57.9 104.0 9.8 -3.8 -1.9 -8.5 -10.2
Number of full sisters 0.6 0.7 1.8 1.4 0.2 -1.1 0.6 0.3
Suffer from ‘nerves’ 0.1 0.2 0.8 -0.9 0.4 -0.2 0.0 -0.2
Overall health rating 0.2 0.5 1.0 -0.6 -0.1 -1.0 0.9 0.7
Chest pain or discomfort 0.8 1.2 3.5 -1.9 -0.3 -1.3 0.2 0.7
Had major operations 0.8 0.9 3.1 1.1 -0.5 0.2 0.1 1.7
Age at last live birth 0.9 1.3 5.7 -0.2 0.0 2.4 -0.5 -0.5
Family relationship satisfaction 0.9 1.1 3.2 -0.1 -1.8 0.8 -1.1 -0.6
Leg pain on walking 0.6 0.8 1.6 -1.0 -0.9 1.2 0.6 -0.4
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.3 3.2 -0.1 -1.2 1.8 0.7 1.1
Commuting to job workplace: Car/motor vehicle 1.2 1.4 2.3 0.2 -1.5 -0.1 1.4 1.5
Illness, injury, bereavement, stress in last 2 years 1.3 1.6 3.3 0.0 0.1 -1.8 -1.7 -1.4
Medication: Aspirin 0.8 1.0 3.9 -0.3 0.6 0.2 0.8 2.0
Supplements: Vitamin C 0.6 0.7 1.3 0.7 0.7 1.1 0.5 0.9
Knee pain experienced in last month 1.4 2.1 7.6 -1.6 -0.7 2.8 -0.2 -0.1
Hypertension (Self-reported) 0.6 1.6 4.6 -0.1 -1.5 -0.4 1.0 2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 2.1 -1.2 0.4 -1.4 -1.4 -0.9
Illnesses of father: Heart disease 2.8 3.9 9.3 0.6 -1.8 -1.4 3.0 2.2
Illnesses of siblings: Diabetes 0.5 0.7 1.9 0.0 0.3 -1.4 0.1 1.1
Smoking status: Previous 1.9 2.8 6.5 1.8 -2.5 -0.3 -1.5 -1.4
Forced expiratory volume in 1-second (FEV1), predicted 3.5 7.3 21.5 4.6 -1.0 -1.3 -2.1 -2.8
Whole body fat-free mass 6.6 37.9 75.5 8.7 -5.1 -1.3 -5.0 -7.8
Leg fat-free mass (right) 4.5 23.9 54.8 7.4 -4.4 -1.1 -3.1 -5.9
Arm fat percentage (left) 0.6 2.5 5.4 0.8 -1.5 -1.2 1.7 2.3
Average weekly red wine intake 0.4 0.5 1.5 -1.2 -1.0 0.0 -0.3 -0.0
Handedness (chirality/laterality): Left-handed 1.0 1.2 1.9 -1.2 1.4 -0.8 -1.1 -0.9
Mood swings 1.0 1.8 6.6 0.2 -0.8 0.1 2.6 1.4
Loneliness, isolation 0.7 1.0 2.5 0.8 -0.5 -1.6 0.1 -1.2
Long-standing illness, disability or infirmity 1.0 1.5 6.2 -2.5 0.5 -0.5 0.9 0.3
Ever had bowel cancer screening 0.9 1.1 1.4 -1.2 0.8 1.2 -1.1 0.8
Diabetes diagnosed by doctor 1.3 2.1 8.4 0.4 0.7 -2.9 0.6 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 3.0 0.8 0.6 1.7 0.3 -0.4
Friendships satisfaction 0.7 0.9 1.9 0.5 -0.9 1.4 0.6 0.9
Qualifications: nursing, teaching 0.5 0.7 1.4 -1.0 0.2 -0.1 1.2 1.1
Commuting to job workplace: Walk 0.5 0.6 1.3 0.6 1.1 -1.1 0.2 0.3
Eye problems/disorders: Cataract 1.2 1.4 3.8 0.1 0.5 2.0 1.6 0.6
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.2 -1.4 0.6 -1.8 0.2 1.0
Medication for cholesterol 0.5 0.7 1.7 1.3 0.9 0.9 -0.3 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 1.2 0.2 1.1 0.4 -0.5 -1.1
Back pain experienced in last month 0.5 0.8 1.7 0.2 0.6 -0.5 -1.3 -1.3
Mineral and other dietary supplements 2.0 2.7 4.5 2.0 -0.5 -2.1 1.4 1.7
Breast cancer (self-reported) 1.0 1.2 5.5 -2.3 0.6 0.3 -0.4 0.1
Asthma (self-reported) 0.6 1.2 2.0 1.4 1.1 -0.5 1.1 1.2
Osteoporosis (self-reported) 1.1 1.3 3.5 -1.0 1.9 1.4 -0.0 -0.4
Osteoarthritis (self-reported) 1.4 1.8 3.9 -1.6 -2.0 1.2 0.1 -1.1
Medication: Aspirin 0.6 0.7 3.2 -0.4 0.3 0.3 0.4 1.8
Medication: Gliclazide 1.1 1.3 4.1 0.3 -0.8 -1.3 0.2 2.0
Illnesses of father: None of the above (group 1) 1.3 1.6 3.1 -1.5 0.3 1.0 -1.4 -1.7
Smoking status: Current 1.2 2.0 3.8 1.0 -0.3 1.9 1.6 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 9.5 -3.1 0.2 -1.6 -1.0 -0.6
Whole body water mass 6.5 37.1 74.8 8.6 -4.9 -1.3 -5.0 -7.7
Leg predicted mass (right) 4.4 23.6 54.8 7.4 -4.4 -1.2 -2.9 -5.8
Arm fat mass (left) 1.0 4.2 9.7 3.1 -2.9 -1.5 -0.4 -0.8
Number of self-reported non-cancer illnesses 1.0 1.8 6.3 0.1 -0.8 -0.3 2.5 1.3
Average weekly champagne plus white wine intake 0.6 0.8 2.8 -1.7 0.7 -0.2 0.3 0.9
Miserableness 0.4 0.6 2.7 -0.1 0.2 -1.6 0.5 -0.4
Guilty feelings 0.6 0.8 2.8 1.7 -0.7 -0.2 0.9 -0.4
Wears glasses or contact lenses 0.4 0.5 0.8 0.9 0.3 -0.6 0.7 -0.8
Ever taken oral contraceptive pill 1.1 1.2 4.2 -2.0 0.6 -0.2 -0.7 -0.9
Hearing aid user 0.7 0.8 3.3 0.2 0.6 -1.8 0.2 -0.1
Mother’s age at death 0.9 1.2 4.0 -2.0 0.8 0.2 -1.0 -0.5
Financial situation satisfaction 0.4 0.5 1.4 -0.6 -0.8 1.2 -0.3 -0.5
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.0 -0.1 -0.5 -1.4 1.7 1.2
Commuting to job workplace: Public transport 1.8 2.1 6.2 -0.4 2.5 1.5 -0.9 -1.1
Eye problems/disorders: Glaucoma 2.6 3.1 5.8 -0.8 2.4 2.1 1.9 0.9
Medication: Blood pressure 0.5 0.9 1.4 -0.9 -1.2 -1.1 0.8 0.7
Pain type(s) experienced in last month: Hip pain 1.1 1.4 3.1 -1.0 -1.8 -1.3 -0.8 -0.5
Supplements: Fish oil (including cod liver oil) 0.7 1.0 2.9 -1.7 -0.3 0.9 -0.4 -1.0
High cholesterol (Self-reported) 1.1 1.9 4.3 0.2 -0.3 -1.6 1.5 2.1
Medication: Bendroflumethiazide 0.2 0.3 1.3 -0.1 -1.1 0.3 0.1 -0.5
Medication: Paracetamol 0.2 0.3 0.6 0.7 0.6 -0.8 -0.3 -0.4
Medication: Lisinopril 0.3 0.4 0.7 -0.0 -0.8 0.7 -0.5 -0.8
Medication: Atorvastatin 0.5 0.6 1.0 -1.0 0.5 -0.9 -0.2 1.0
Illnesses of father: High blood pressure 0.8 1.0 2.0 1.1 1.4 -1.1 0.6 0.5
Alcohol drinker status: Never 3.2 3.9 10.2 0.8 1.4 -1.9 3.2 1.8
Ever smoked 1.0 1.7 2.0 1.3 -1.3 1.4 -1.0 -1.4
Basal metabolic rate 5.8 31.9 69.2 8.3 -4.9 -1.5 -4.2 -6.8
Leg fat percentage (left) 0.6 2.2 5.9 0.7 -0.5 -1.3 1.6 2.4
Arm fat-free mass (left) 6.1 30.8 59.3 7.7 -4.5 -1.3 -4.8 -7.1
Number of operations (self-reported) 0.5 0.7 1.5 -0.2 0.7 1.2 0.4 1.1
Average weekly beer plus cider intake 2.1 3.1 13.7 3.7 -1.0 0.2 0.8 -0.0
Irritability 0.1 0.2 1.1 -0.2 0.1 -1.0 -0.3 -0.1
Risk taking 0.5 0.8 3.1 0.2 0.5 1.8 0.6 0.5
Ever had prostate specific antigen (PSA) test 1.1 1.3 3.9 -2.0 0.7 -1.3 -0.4 -0.0
Fractured/broken bones in last 5 years 2.2 2.9 11.6 -1.3 3.4 -0.8 -0.7 -0.2
Age started oral contraceptive pill 1.4 1.8 2.8 -1.2 1.1 1.0 -1.6 -1.7
Diastolic blood pressure, automated reading 0.9 2.9 5.6 1.3 -1.2 -2.4 2.0 1.3
Ever depressed for a whole week 0.3 0.4 0.9 0.2 1.0 -0.8 0.6 -0.4
Unable to work because of sickness or disability 0.4 0.6 1.0 -1.0 -0.6 0.8 0.9 -0.4
Commuting to job workplace: Cycle 2.0 2.4 4.8 -0.8 -0.7 1.3 -2.2 -2.1
Myopia 0.5 0.8 1.8 1.3 -0.1 -0.7 -1.3 0.1
Vascular/heart problems diagnosed by doctor 0.5 1.3 4.1 0.2 1.1 0.4 -1.0 -2.0
Cholesterol lowering medication 0.9 1.3 3.8 -1.9 0.4 -1.1 0.0 1.2
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 2.1 -1.2 -0.4 -1.1 -1.4 -0.6
Pain experienced in last month 0.3 0.5 2.0 -0.4 0.1 -1.4 0.0 0.4
Supplements: Calcium 2.2 2.5 6.6 -1.7 1.1 2.6 -0.5 -1.2
Basal cell carcinoma (self-reported) 0.4 0.5 1.4 -0.1 0.4 -0.8 1.2 0.6
Heart attack/myocardial infarction (self-reported) 0.5 0.7 1.9 -0.4 -1.0 -0.2 1.4 0.5
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.2 1.1 -1.5 0.1 -0.7 -1.4
Heart disease (siblings) 1.0 1.3 4.5 -2.1 -0.1 -0.8 0.4 -1.0
Alcohol drinker status: Previous 0.2 0.2 0.5 0.2 0.2 0.4 0.7 0.6
Pack years of smoking 0.2 0.2 0.8 0.3 -0.0 0.2 0.9 0.4
Impedance of whole body 0.9 4.5 9.7 -0.6 3.1 -1.0 1.6 3.0
Leg fat mass (left) 1.1 4.2 12.6 3.5 -2.2 -1.8 -0.4 -0.6
Arm predicted mass (left) 6.1 31.2 58.7 7.7 -4.6 -1.3 -4.8 -7.2