TWAS hub - FNDC3B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0730	0.0270	4.8e-03	0.060	0.018	0.054	0.020	0.000	8.0e-08	2.6e-03	3.2e-07	1.3e-03	3.1e-01
2	METSIM	Adipose	0.0941	0.0261	6.2e-06	0.078	0.021	0.066	0.062	0.073	8.2e-12	3.2e-04	3.4e-10	1.5e-09	5.0e-11
3	YFS	Blood	0.0559	0.0165	2.2e-05	0.000	0.016	0.016	0.018	0.002	3.7e-01	3.1e-06	3.8e-06	1.4e-06	5.8e-02
4	TCGA	Glioblastoma Multiforme	0.2680	0.1000	6.3e-03	0.050	0.024	0.072	NA	0.082	1.3e-02	6.1e-02	3.3e-03	NA	1.8e-03
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0723	0.0318	5.1e-03	0.023	0.011	0.018	NA	0.017	1.2e-03	1.6e-02	3.9e-03	NA	4.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Comparative height size at age 10	10.5	57.9	104.0	9.8	-3.8	-1.9	-8.5	-10.2
Height	7.9	152.9	408.0	20.2	-4.6	-3.8	-10.4	-14.6
Trunk fat-free mass	7.7	44.3	86.9	9.3	-5.2	-1.3	-5.7	-8.6
Trunk predicted mass	7.6	43.5	82.8	9.1	-5.1	-1.3	-5.8	-8.6
Standing height	7.4	73.0	190.4	13.8	-3.8	-3.6	-6.7	-10.1
Arm predicted mass (right)	6.8	34.6	68.6	8.3	-4.8	-1.4	-5.0	-7.4
Arm fat-free mass (right)	6.6	33.8	66.6	8.2	-4.6	-1.2	-5.0	-7.4
Whole body fat-free mass	6.6	37.9	75.5	8.7	-5.1	-1.3	-5.0	-7.8
Whole body water mass	6.5	37.1	74.8	8.6	-4.9	-1.3	-5.0	-7.7
Arm fat-free mass (left)	6.1	30.8	59.3	7.7	-4.5	-1.3	-4.8	-7.1
Arm predicted mass (left)	6.1	31.2	58.7	7.7	-4.6	-1.3	-4.8	-7.2
Basal metabolic rate	5.8	31.9	69.2	8.3	-4.9	-1.5	-4.2	-6.8
Sitting height	5.1	35.9	75.0	8.7	-2.1	-3.3	-5.0	-8.0
Leg fat-free mass (left)	4.7	24.8	58.1	7.6	-4.3	-1.4	-3.3	-5.9
Leg predicted mass (left)	4.7	24.9	57.3	7.6	-4.4	-1.5	-3.3	-5.9
Pulse rate, automated reading	4.5	14.5	30.0	2.2	-1.3	-2.5	5.5	5.5
Leg fat-free mass (right)	4.5	23.9	54.8	7.4	-4.4	-1.1	-3.1	-5.9
Leg predicted mass (right)	4.4	23.6	54.8	7.4	-4.4	-1.2	-2.9	-5.8
Forced vital capacity (FVC), Best measure	3.6	13.0	34.0	2.7	-1.6	-1.5	-4.3	-5.8
Forced vital capacity (FVC)	3.5	13.3	33.4	2.6	-1.7	-1.7	-4.5	-5.8
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.3	21.5	4.6	-1.0	-1.3	-2.1	-2.8
Forced expiratory volume in 1-second (FEV1)	3.2	10.9	24.3	1.2	-1.6	-1.9	-4.9	-4.8
Alcohol drinker status: Never	3.2	3.9	10.2	0.8	1.4	-1.9	3.2	1.8
Weight	3.1	15.4	42.2	6.5	-3.6	-2.1	-1.9	-3.7
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.4	22.9	0.8	-1.6	-1.5	-4.3	-4.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.0	3.6	11.0	-0.8	1.2	0.6	2.1	3.3
Illnesses of father: Heart disease	2.8	3.9	9.3	0.6	-1.8	-1.4	3.0	2.2
Age when periods started (menarche)	2.7	6.5	18.0	-0.8	-0.8	-0.4	4.2	3.6
Glaucoma (self-reported)	2.7	3.1	5.3	-1.7	1.8	1.8	2.3	0.8
Hair/balding pattern: Pattern 3	2.6	3.8	10.7	0.2	2.0	0.9	3.3	1.9
Medication: Lansoprazole	2.6	3.0	10.6	-3.3	-0.6	-1.1	0.4	-1.6
Eye problems/disorders: Glaucoma	2.6	3.1	5.8	-0.8	2.4	2.1	1.9	0.9
Hand grip strength (right)	2.4	6.6	16.6	4.1	-2.6	-1.4	-1.3	-2.4
High blood pressure (mother)	2.3	3.2	7.3	-0.4	-1.0	-1.9	2.0	2.7
Father’s age at death	2.3	3.1	5.7	-1.4	2.4	-0.8	-2.1	-1.7
Pulse rate	2.3	4.0	11.2	0.9	0.0	-1.1	2.5	3.3
Eye problems/disorders: None of the above	2.3	2.6	7.7	-0.3	-1.3	-1.7	-2.8	-0.9
Fractured/broken bones in last 5 years	2.2	2.9	11.6	-1.3	3.4	-0.8	-0.7	-0.2
Supplements: Calcium	2.2	2.5	6.6	-1.7	1.1	2.6	-0.5	-1.2
Waist Hip Ratio (WHR)	2.1	9.6	16.2	3.1	-2.1	-1.9	3.8	4.0
Peak expiratory flow (PEF)	2.1	4.8	8.0	0.8	-2.4	-1.4	-2.7	-2.8
Average weekly beer plus cider intake	2.1	3.1	13.7	3.7	-1.0	0.2	0.8	-0.0
Mineral and other dietary supplements	2.0	2.7	4.5	2.0	-0.5	-2.1	1.4	1.7
Commuting to job workplace: Cycle	2.0	2.4	4.8	-0.8	-0.7	1.3	-2.2	-2.1
HbA1C	1.9	2.2	5.2	0.7	0.5	0.3	-2.2	-2.3
Diabetes (self-reported)	1.9	3.0	13.1	0.5	0.5	-3.6	0.5	1.0
Happiness	1.9	2.3	7.0	-0.7	-0.7	-0.1	2.6	1.8
Smoking status: Previous	1.9	2.8	6.5	1.8	-2.5	-0.3	-1.5	-1.4
Prospective memory result	1.8	2.2	4.1	2.0	0.8	-0.6	-1.5	-1.8
Pulse wave reflection index	1.8	2.3	6.0	-1.1	0.6	1.3	-1.4	-2.4
Health satisfaction	1.8	2.3	4.7	-1.1	1.0	0.8	2.2	2.0
Commuting to job workplace: Public transport	1.8	2.1	6.2	-0.4	2.5	1.5	-0.9	-1.1
Alzheimer’s Disease (in father)	1.7	1.9	5.7	0.4	0.4	-2.4	1.8	0.2
Townsend deprivation index at recruitment	1.7	2.4	3.4	0.9	1.2	-1.8	-1.7	-1.8
Supplements: Glucosamine	1.7	2.2	4.9	-1.1	-1.3	2.2	-1.0	-1.5
Alcohol intake versus 10 years previously	1.7	2.6	8.8	3.0	1.0	0.3	-1.3	-1.2
Schizophrenia vs Biploar Disorder	1.6	2.1	7.2	-2.7	1.1	-0.9	0.0	-1.3
Hand grip strength (left)	1.6	4.3	13.0	3.6	-1.8	-0.2	-1.0	-2.1
Relative age of first facial hair	1.6	3.4	6.2	1.3	1.6	-0.3	2.5	2.5
Multivitamins +/- minerals	1.6	2.1	6.6	-1.0	1.1	-0.2	-1.2	-2.6
Illnesses of siblings	1.6	2.2	3.2	1.8	-0.5	1.4	-1.6	-1.7
Hip circumference	1.6	6.7	20.3	4.5	-1.7	-2.2	-0.9	-2.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	3.1	-0.2	1.7	-0.9	1.8	1.2
Severe depression (siblings)	1.5	1.7	5.7	-0.1	-0.5	-0.1	-1.5	-2.4
Had menopause	1.5	1.9	5.1	-1.3	-1.1	0.4	-1.2	-2.2
Exposure to tobacco smoke at home	1.5	1.7	4.5	2.1	-0.4	0.7	-1.0	-1.5
Body Mass Index (BMI) (2010)	1.4	1.9	4.4	-0.4	-0.2	2.1	-1.7	-1.3
HDL Cholesterol	1.4	2.3	6.2	-1.8	0.7	-0.1	1.4	2.5
Blood White Count	1.4	10.1	29.3	-3.2	-0.5	-1.4	3.0	5.4
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	4.4	-2.1	0.1	1.9	-0.4	0.2
Trunk fat mass	1.4	6.0	19.4	4.4	-2.1	-2.3	-0.2	-0.7
Waist circumference	1.4	5.1	12.6	3.5	-2.7	-2.0	1.3	0.6
Worrier / anxious feelings	1.4	2.7	8.4	0.0	1.0	-0.4	2.9	2.0
High blood pressure (siblings)	1.4	2.0	3.6	-1.9	0.1	-0.9	1.6	1.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.6	-1.0	-0.2	0.7	-1.4	-2.4
Knee pain experienced in last month	1.4	2.1	7.6	-1.6	-0.7	2.8	-0.2	-0.1
Osteoarthritis (self-reported)	1.4	1.8	3.9	-1.6	-2.0	1.2	0.1	-1.1
Age started oral contraceptive pill	1.4	1.8	2.8	-1.2	1.1	1.0	-1.6	-1.7
Triglycerides	1.3	2.1	3.6	0.9	-1.9	1.4	-1.4	-1.3
Type 2 Diabetes (T2D) (2018)	1.3	2.4	8.3	-0.2	-0.1	-2.9	1.4	1.2
Medication: Metformin	1.3	1.9	5.7	-0.1	0.1	-2.4	0.7	1.8
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	5.3	-0.3	-2.3	-0.5	-1.4	-1.0
Medication: Allopurinol	1.3	1.8	4.8	1.2	-0.5	-2.2	0.9	1.3
Whole body fat mass	1.3	5.4	17.0	4.1	-2.2	-2.2	-0.3	-0.7
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	3.3	0.0	0.1	-1.8	-1.7	-1.4
Diabetes diagnosed by doctor	1.3	2.1	8.4	0.4	0.7	-2.9	0.6	1.0
Illnesses of father: None of the above (group 1)	1.3	1.6	3.1	-1.5	0.3	1.0	-1.4	-1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	9.5	-3.1	0.2	-1.6	-1.0	-0.6
Worry (Nagel 2018)	1.2	2.6	8.4	-0.4	0.6	-0.4	2.9	2.0
Ovarian Cancer	1.2	1.5	2.6	1.0	-1.6	-1.3	-1.2	1.0
Cardiovascular Disease	1.2	3.9	8.2	-1.3	-2.4	-0.9	1.8	2.9
Ever used hormone-replacement therapy (HRT)	1.2	1.6	5.0	-0.4	0.2	2.2	0.6	-1.5
Qualifications: A levels/AS levels or equivalent	1.2	2.7	12.0	-0.3	3.5	-0.2	-0.0	1.3
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	3.3	-0.3	1.8	-1.1	-1.3	-1.3
Illnesses of mother	1.2	1.4	2.7	-0.9	0.4	1.0	-1.5	-1.7
Blood clot in the leg (DVT)	1.2	1.5	2.7	1.6	-1.3	0.2	-1.1	-1.5
Medication: Ventolin 100micrograms inhaler	1.2	1.6	6.7	2.6	0.5	0.0	-0.9	-0.4
Medication: Ibuprofen	1.2	1.5	4.2	0.2	2.1	-0.4	-1.1	-1.3
Leg fat mass (right)	1.2	4.5	12.7	3.6	-2.2	-2.1	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.3	0.2	-1.5	-0.1	1.4	1.5
Eye problems/disorders: Cataract	1.2	1.4	3.8	0.1	0.5	2.0	1.6	0.6
Smoking status: Current	1.2	2.0	3.8	1.0	-0.3	1.9	1.6	1.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.0	-0.1	-0.5	-1.4	1.7	1.2
Ulcerative Colitis (UC)	1.1	2.2	9.6	1.0	-0.0	0.4	0.0	3.1
Current tobacco smoking	1.1	1.7	2.7	1.6	-0.2	1.4	1.4	1.5
Relative age voice broke	1.1	1.6	4.0	1.3	0.7	-0.3	1.4	2.0
Past tobacco smoking	1.1	2.1	4.5	-1.1	2.1	-1.1	1.1	1.5
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.2	0.5	0.8	0.7	1.3	1.8
Number of full brothers	1.1	1.4	2.6	-0.7	0.2	1.4	-1.6	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	2.1	-1.2	0.4	-1.4	-1.4	-0.9
Osteoporosis (self-reported)	1.1	1.3	3.5	-1.0	1.9	1.4	-0.0	-0.4
Medication: Gliclazide	1.1	1.3	4.1	0.3	-0.8	-1.3	0.2	2.0
Ever taken oral contraceptive pill	1.1	1.2	4.2	-2.0	0.6	-0.2	-0.7	-0.9
Pain type(s) experienced in last month: Hip pain	1.1	1.4	3.1	-1.0	-1.8	-1.3	-0.8	-0.5
High cholesterol (Self-reported)	1.1	1.9	4.3	0.2	-0.3	-1.6	1.5	2.1
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.9	-2.0	0.7	-1.3	-0.4	-0.0
Leg fat mass (left)	1.1	4.2	12.6	3.5	-2.2	-1.8	-0.4	-0.6
Irritable Bowel Disease (IBD)	1.0	2.3	8.9	1.5	-0.1	-0.0	0.5	3.0
Ulcerative Colitis	1.0	1.5	6.5	0.7	-0.2	-0.1	0.5	2.5
Systolic blood pressure, automated reading	1.0	2.9	5.6	1.0	-1.5	-2.4	1.4	1.9
Vitamin and mineral supplements	1.0	1.3	3.5	1.9	-0.9	-0.8	0.6	1.1
Diabetes (mother)	1.0	1.3	2.8	1.5	0.7	0.1	-1.7	-0.8
Maternal smoking around birth	1.0	1.4	4.2	2.1	-0.1	1.7	0.2	-0.0
Qualifications: CSEs or equivalent	1.0	1.3	2.6	-0.7	-1.1	1.1	1.1	1.6
Alcohol usually taken with meals	1.0	1.6	5.0	-2.2	0.3	-1.0	0.6	1.3
Medication: Simvastatin	1.0	1.5	4.3	-1.1	0.3	-2.1	0.8	1.0
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.6	2.7	-0.6	0.8	-1.6	1.6	1.4
Birth weight of first child	1.0	1.8	6.2	2.5	1.4	0.3	-0.7	-0.8
Medication: Omeprazole	1.0	1.2	3.5	-0.8	0.5	-1.9	-1.2	-0.5
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	3.2	-0.1	-1.2	1.8	0.7	1.1
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.9	-1.2	1.4	-0.8	-1.1	-0.9
Mood swings	1.0	1.8	6.6	0.2	-0.8	0.1	2.6	1.4
Long-standing illness, disability or infirmity	1.0	1.5	6.2	-2.5	0.5	-0.5	0.9	0.3
Breast cancer (self-reported)	1.0	1.2	5.5	-2.3	0.6	0.3	-0.4	0.1
Arm fat mass (left)	1.0	4.2	9.7	3.1	-2.9	-1.5	-0.4	-0.8
Number of self-reported non-cancer illnesses	1.0	1.8	6.3	0.1	-0.8	-0.3	2.5	1.3
Ever smoked	1.0	1.7	2.0	1.3	-1.3	1.4	-1.0	-1.4
Heart disease (siblings)	1.0	1.3	4.5	-2.1	-0.1	-0.8	0.4	-1.0
Age at First Birth	0.9	1.3	5.0	-0.2	2.2	0.2	1.2	-0.0
Bipolar Disorder (2011)	0.9	0.9	2.7	1.3	-0.4	-1.6	0.0	-0.0
Systolic Blood Pressure	0.9	4.4	11.0	1.1	-3.3	-1.4	1.8	2.1
Allergy or Eczema	0.9	2.4	7.9	-0.5	1.3	2.8	0.7	1.2
Lung FVC	0.9	4.4	10.9	-3.3	0.8	-0.3	-1.5	-2.9
Neuroticism	0.9	2.1	7.7	-0.1	0.2	-0.8	2.8	1.4
Sensitivity / hurt feelings	0.9	1.6	3.6	-0.8	1.2	-1.1	1.9	1.0
Medication: Co-codamol	0.9	1.0	2.0	-0.3	-1.0	-0.4	-1.4	-1.3
Diabetes (father)	0.9	1.1	3.6	0.1	-0.8	0.3	-1.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.3	0.8	-0.9	1.5	2.1	1.4
Medication: Ramipril	0.9	1.2	4.0	-0.2	-0.9	-0.7	2.0	0.7
Impedance of arm (right)	0.9	4.4	8.8	-0.7	2.9	-0.6	2.0	3.0
Impedance of arm (left)	0.9	4.3	10.0	-0.3	2.7	-0.6	2.0	3.2
Loud music exposure frequency	0.9	1.0	1.5	-1.2	-0.7	1.1	-0.4	-1.2
Headache pain in last month	0.9	1.5	3.7	0.2	1.8	0.0	-0.8	-1.9
Medication: Amlodipine	0.9	1.3	3.8	-1.9	-0.6	1.2	-0.8	0.4
Birth weight	0.9	2.0	7.6	2.8	-0.8	0.5	-0.1	-1.3
Exposure to tobacco smoke outside home	0.9	1.3	3.6	-0.8	0.7	-1.2	-0.3	-1.9
Migraine (self-reported)	0.9	1.1	2.8	1.2	-0.8	-0.2	-0.7	-1.7
Age at last live birth	0.9	1.3	5.7	-0.2	0.0	2.4	-0.5	-0.5
Family relationship satisfaction	0.9	1.1	3.2	-0.1	-1.8	0.8	-1.1	-0.6
Ever had bowel cancer screening	0.9	1.1	1.4	-1.2	0.8	1.2	-1.1	0.8
Mother’s age at death	0.9	1.2	4.0	-2.0	0.8	0.2	-1.0	-0.5
Diastolic blood pressure, automated reading	0.9	2.9	5.6	1.3	-1.2	-2.4	2.0	1.3
Cholesterol lowering medication	0.9	1.3	3.8	-1.9	0.4	-1.1	0.0	1.2
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.1	-1.2	-0.4	-1.1	-1.4	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.2	1.1	-1.5	0.1	-0.7	-1.4
Impedance of whole body	0.9	4.5	9.7	-0.6	3.1	-1.0	1.6	3.0
Neuroticism (Nagel 2018)	0.8	1.8	7.2	0.3	-0.1	-0.7	2.7	1.1
Reaction Time	0.8	1.6	4.8	-2.2	1.7	0.2	0.3	0.3
Breast Cancer	0.8	2.0	5.6	0.2	-0.3	-0.6	1.9	2.4
Smoking Status	0.8	1.8	4.5	1.0	-2.1	1.7	-0.7	-0.4
Supplements: Zinc	0.8	0.9	2.2	1.4	1.5	-0.3	-0.4	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.1	2.0	-1.4	-1.2	-0.0	1.4	-0.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	2.9	-0.8	0.2	-0.1	1.7	-0.7
Serious illness, injury or assault to yourself	0.8	1.0	2.1	-0.4	0.6	-0.7	1.5	1.3
Mouth/teeth dental problems	0.8	1.3	4.2	-0.1	2.1	0.8	0.5	1.1
Pain all over the body in last month	0.8	0.9	1.8	-1.0	-0.7	-1.3	1.1	-0.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.0	0.5	0.5	0.7	1.7	1.3
Neuroticism score	0.8	1.6	6.3	0.1	-0.1	-0.7	2.5	1.2
Medication: Cholesterol lowering	0.8	1.3	2.9	0.4	-0.5	-1.4	1.7	1.1
Lung cancer (father)	0.8	1.0	2.8	0.2	0.0	0.6	-1.7	-1.3
Arm fat mass (right)	0.8	3.2	7.8	2.8	-2.4	-1.5	0.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.6	0.5	-1.2	-1.0	1.6	0.9
Hair/balding pattern: Pattern 4	0.8	2.0	4.6	-0.3	-2.2	0.6	-1.9	-1.2
Comparative body size at age 10	0.8	2.2	7.0	-0.5	-2.6	1.2	-0.4	-1.5
Pulse wave peak to peak time	0.8	1.0	3.6	1.9	0.5	-0.5	-0.8	-0.3
Shortness of breath walking on level ground	0.8	0.9	2.1	-0.3	-0.8	1.4	0.7	1.2
Mean time to correctly identify matches	0.8	1.6	4.0	-2.0	1.6	-0.3	0.7	0.9
Chest pain or discomfort	0.8	1.2	3.5	-1.9	-0.3	-1.3	0.2	0.7
Had major operations	0.8	0.9	3.1	1.1	-0.5	0.2	0.1	1.7
Medication: Aspirin	0.8	1.0	3.9	-0.3	0.6	0.2	0.8	2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.0	0.8	0.6	1.7	0.3	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.2	-1.4	0.6	-1.8	0.2	1.0
Illnesses of father: High blood pressure	0.8	1.0	2.0	1.1	1.4	-1.1	0.6	0.5
Intelligence (Savage-Jansen 2018)	0.7	2.1	7.8	2.8	1.6	-0.2	-0.0	0.1
Crohns Disease (2017)	0.7	1.6	4.5	1.6	-0.4	-0.1	1.0	2.1
Major Depression (MDD)	0.7	0.8	2.6	-0.1	0.1	-1.2	-0.3	-1.6
Prostate Cancer	0.7	1.0	2.8	-0.8	0.8	0.1	-1.7	-0.9
Mean Putamen Volume	0.7	0.8	2.1	0.1	0.1	1.4	-1.1	1.0
Neuroticism (2016)	0.7	1.0	2.2	-1.5	0.2	-0.6	0.5	-1.4
Primary Biliary Cirrhosis	0.7	1.0	2.4	-0.1	-0.4	-0.7	-1.5	-1.3
Rheumatoid Arthritis	0.7	1.0	3.4	0.1	0.2	-0.2	-1.2	-1.8
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.9	-0.1	1.3	1.7	1.4	0.8
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.5	-0.9	1.2	-0.5	0.6	1.0
Hair/balding pattern: Pattern 2	0.7	0.9	3.5	-0.1	-1.9	-0.6	-0.9	-0.1
Had other major operations	0.7	0.8	2.5	-1.6	0.0	0.9	-1.0	0.1
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.4	-0.4	1.5	-0.3	1.4	0.3
Emphysema/chronic bronchitis	0.7	0.8	2.2	-0.7	0.9	-1.5	-0.5	0.6
Loneliness, isolation	0.7	1.0	2.5	0.8	-0.5	-1.6	0.1	-1.2
Friendships satisfaction	0.7	0.9	1.9	0.5	-0.9	1.4	0.6	0.9
Hearing aid user	0.7	0.8	3.3	0.2	0.6	-1.8	0.2	-0.1
Supplements: Fish oil (including cod liver oil)	0.7	1.0	2.9	-1.7	-0.3	0.9	-0.4	-1.0
Depressed Affect (Nagel 2018)	0.6	1.3	3.6	1.0	-1.0	-0.7	1.9	0.5
Crohns Disease (2012)	0.6	1.0	2.8	1.7	-0.9	-0.3	0.7	0.8
Hearing difficulty/problems: Yes	0.6	0.9	3.4	0.8	1.9	-0.8	0.2	0.0
Angina	0.6	0.8	2.9	-0.1	0.5	-0.0	1.0	1.7
Medication for hormone replacement therapy	0.6	0.7	2.8	-0.2	-0.1	-0.7	-0.1	-1.7
Impedance of leg (right)	0.6	2.9	8.0	-0.4	2.8	-1.7	-0.0	1.9
Trunk fat percentage	0.6	2.4	4.6	2.2	-0.8	-1.7	1.2	1.5
Stomach or abdominal pain in last month	0.6	0.7	3.2	0.2	0.0	1.8	0.6	0.3
Chronic bronchitis/emphysema (father)	0.6	0.7	1.0	0.8	-1.0	0.5	0.6	1.0
Impedance of leg (left)	0.6	3.1	8.5	-0.6	2.9	-1.2	0.6	2.3
Arm fat percentage (right)	0.6	2.4	5.6	0.2	-1.3	-1.0	1.9	2.4
Time employed in main current job	0.6	0.7	2.3	-0.6	0.4	-0.5	1.5	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	0.5	0.7	1.5	0.8	0.3
Mouth/teeth dental problems: Dentures	0.6	1.0	4.0	-0.3	-2.0	0.4	0.4	-0.8
Asthma	0.6	1.1	1.6	1.2	1.1	-0.8	1.0	1.1
Depression (self-reported)	0.6	0.8	1.9	-0.3	1.3	-1.4	-0.2	-0.2
Breastfed as a baby	0.6	0.8	2.6	-0.9	-0.7	0.2	-1.6	-0.0
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.8	-1.3	1.1	0.1	-0.2	-0.8
Body fat percentage	0.6	2.4	4.1	1.6	-0.9	-1.6	1.4	2.0
Leg fat percentage (right)	0.6	2.3	5.7	0.9	-0.5	-1.8	1.3	2.4
Number of children fathered	0.6	0.7	1.7	1.3	0.2	0.6	-0.7	-0.9
Mouth/teeth dental problems: Loose teeth	0.6	0.8	2.3	0.4	-1.5	-0.3	-0.7	-0.8
Angina (self-reported)	0.6	0.8	3.0	-0.1	0.4	0.2	0.9	1.7
Number of full sisters	0.6	0.7	1.8	1.4	0.2	-1.1	0.6	0.3
Leg pain on walking	0.6	0.8	1.6	-1.0	-0.9	1.2	0.6	-0.4
Supplements: Vitamin C	0.6	0.7	1.3	0.7	0.7	1.1	0.5	0.9
Hypertension (Self-reported)	0.6	1.6	4.6	-0.1	-1.5	-0.4	1.0	2.1
Arm fat percentage (left)	0.6	2.5	5.4	0.8	-1.5	-1.2	1.7	2.3
Asthma (self-reported)	0.6	1.2	2.0	1.4	1.1	-0.5	1.1	1.2
Medication: Aspirin	0.6	0.7	3.2	-0.4	0.3	0.3	0.4	1.8
Average weekly champagne plus white wine intake	0.6	0.8	2.8	-1.7	0.7	-0.2	0.3	0.9
Guilty feelings	0.6	0.8	2.8	1.7	-0.7	-0.2	0.9	-0.4
Leg fat percentage (left)	0.6	2.2	5.9	0.7	-0.5	-1.3	1.6	2.4
Alzheimer’s Disease (including proxy)	0.5	0.7	2.4	-0.2	0.1	-1.5	1.1	0.1
Lupus	0.5	0.8	2.8	1.7	-0.4	-0.9	0.4	-0.3
Type 2 Diabetes (T2D) (2012)	0.5	0.6	2.1	0.0	-1.4	-0.4	0.8	0.5
Lung FEV1/FVC ratio	0.5	2.5	4.9	-2.0	0.5	-0.5	-2.2	1.7
Ever had hysterectomy (womb removed)	0.5	0.5	1.2	-0.6	-1.1	0.2	-0.9	-0.5
Average weekly fortified wine intake	0.5	0.6	2.4	-0.5	1.5	0.1	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	1.6	1.3	-1.2	1.0	1.2	0.8
High blood pressure	0.5	1.5	4.7	-0.2	-1.3	-0.3	1.1	2.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.7	-0.9	0.2	0.1	1.7	0.5
Falls in the last year	0.5	0.7	1.5	-0.5	1.2	-0.4	1.2	0.4
Number of live births	0.5	0.7	1.4	-0.9	-1.2	0.9	-0.5	-0.4
Noisy workplace	0.5	0.6	1.9	-0.2	-0.8	1.4	0.8	0.1
Illnesses of siblings: Diabetes	0.5	0.7	1.9	0.0	0.3	-1.4	0.1	1.1
Qualifications: nursing, teaching	0.5	0.7	1.4	-1.0	0.2	-0.1	1.2	1.1
Commuting to job workplace: Walk	0.5	0.6	1.3	0.6	1.1	-1.1	0.2	0.3
Medication for cholesterol	0.5	0.7	1.7	1.3	0.9	0.9	-0.3	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	1.2	0.2	1.1	0.4	-0.5	-1.1
Back pain experienced in last month	0.5	0.8	1.7	0.2	0.6	-0.5	-1.3	-1.3
Medication: Blood pressure	0.5	0.9	1.4	-0.9	-1.2	-1.1	0.8	0.7
Medication: Atorvastatin	0.5	0.6	1.0	-1.0	0.5	-0.9	-0.2	1.0
Number of operations (self-reported)	0.5	0.7	1.5	-0.2	0.7	1.2	0.4	1.1
Risk taking	0.5	0.8	3.1	0.2	0.5	1.8	0.6	0.5
Myopia	0.5	0.8	1.8	1.3	-0.1	-0.7	-1.3	0.1
Vascular/heart problems diagnosed by doctor	0.5	1.3	4.1	0.2	1.1	0.4	-1.0	-2.0
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.9	-0.4	-1.0	-0.2	1.4	0.5
Depression (Nagel 2018)	0.4	0.6	1.8	-0.8	-0.6	0.1	1.3	-0.3
Verbal and Numeric Reasoning (VNR)	0.4	1.0	2.7	1.6	0.7	-0.7	1.1	0.5
Fasting Glucose	0.4	0.5	1.6	-0.3	0.0	0.8	-0.6	-1.3
Schizophrenia (2014)	0.4	1.0	3.2	-1.1	0.4	0.1	-0.3	-1.8
Blood Eosinophil Count	0.4	2.9	4.7	-1.2	2.0	1.9	0.9	2.2
Heel T-Score	0.4	3.5	6.9	1.6	-1.0	1.8	1.9	2.6
BMI	0.4	2.1	5.9	-0.7	-2.4	-0.6	1.3	1.4
Average weekly spirits intake	0.4	0.5	1.2	-0.7	-0.0	1.1	0.4	-0.6
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.7	-0.1	-0.5	1.2	-0.8
Medication: Levothyroxine sodium	0.4	0.7	1.9	0.4	0.8	0.4	1.4	0.8
Nervous feelings	0.4	0.7	2.6	-0.7	0.3	0.1	1.6	0.4
Qualifications: None of the above	0.4	0.9	3.0	0.5	-1.7	0.3	0.9	0.6
Financial difficulties in last 2 years	0.4	0.6	1.1	1.1	-0.5	-0.7	0.7	0.7
Heart attack	0.4	0.5	1.3	0.0	-1.0	-0.3	1.2	0.4
Allergy	0.4	0.9	1.4	-0.7	-1.0	-1.2	-1.2	-0.6
Pulse wave Arterial Stiffness index	0.4	0.4	0.9	-0.9	-0.9	0.3	0.4	-0.5
Tense / ‘highly strung’	0.4	0.7	1.8	0.5	-1.0	-0.4	1.4	0.6
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.0	1.2	1.4	0.0	0.2	-0.0
Worry too long after embarrassment	0.4	0.7	2.7	0.0	0.2	0.9	1.6	-0.0
Heart disease (mother)	0.4	0.5	1.8	1.3	0.4	-0.8	-0.0	0.2
Alcohol intake frequency.	0.4	1.0	3.7	0.8	0.8	-1.9	0.1	0.5
Average weekly red wine intake	0.4	0.5	1.5	-1.2	-1.0	0.0	-0.3	-0.0
Miserableness	0.4	0.6	2.7	-0.1	0.2	-1.6	0.5	-0.4
Wears glasses or contact lenses	0.4	0.5	0.8	0.9	0.3	-0.6	0.7	-0.8
Financial situation satisfaction	0.4	0.5	1.4	-0.6	-0.8	1.2	-0.3	-0.5
Unable to work because of sickness or disability	0.4	0.6	1.0	-1.0	-0.6	0.8	0.9	-0.4
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-0.1	0.4	-0.8	1.2	0.6
Bipolar Disorder (2018)	0.3	0.5	0.8	0.9	-0.5	0.6	-0.8	-0.6
Blood Platelet Count	0.3	3.8	11.0	-2.0	2.0	-3.3	-0.4	-0.1
Hypothyroidism (self reported)	0.3	0.7	2.2	1.5	0.7	-0.1	-0.4	-0.9
Chronotype (morning person)	0.3	0.7	1.6	-1.0	-0.4	1.3	-0.1	0.8
Number of treatments/medications taken	0.3	0.5	1.0	-0.8	1.0	0.4	0.7	0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.2	-0.4	0.5	-0.8	1.1	0.2
Body mass index (BMI)	0.3	1.1	3.9	0.3	-2.0	-0.4	1.0	0.6
Hearing difficulty/problems with background noise	0.3	0.5	1.4	0.3	0.7	-0.3	1.2	0.6
Fluid intelligence score	0.3	0.6	1.7	-0.2	1.3	-1.2	0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.5	-0.4	1.2	-0.0	-0.2	0.8
Age at first live birth	0.3	0.5	0.6	-0.2	0.8	0.7	-0.7	-0.7
Qualifications: College or University degree	0.3	1.0	1.8	-0.0	1.3	-0.0	-1.4	-1.2
Neck or shoulder pain in last month	0.3	0.4	1.8	-0.2	0.3	0.3	0.3	1.3
Medication: Blood pressure	0.3	0.5	2.2	-0.1	-0.0	1.5	-0.1	0.5
Medication: Lisinopril	0.3	0.4	0.7	-0.0	-0.8	0.7	-0.5	-0.8
Ever depressed for a whole week	0.3	0.4	0.9	0.2	1.0	-0.8	0.6	-0.4
Pain experienced in last month	0.3	0.5	2.0	-0.4	0.1	-1.4	0.0	0.4
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.5	-0.3	0.9	0.2	-0.1
LDL Cholesterol	0.2	0.3	0.6	0.2	-0.7	-0.7	0.6	-0.3
Respiratory disease	0.2	0.5	1.1	1.1	-0.2	-1.1	-0.3	0.5
Pack years adult smoking proportion	0.2	0.3	0.9	0.3	0.1	0.1	1.0	0.5
Fed-up feelings	0.2	0.3	0.9	-0.3	-0.3	-1.0	0.6	-0.3
Taking other prescription medications	0.2	0.3	0.7	0.4	0.3	-0.9	0.6	-0.0
Number of incorrect matches in round	0.2	0.3	0.8	-0.8	-0.5	0.2	-0.1	-0.9
Medication: Paracetamol	0.2	0.3	0.5	0.7	0.6	-0.5	-0.5	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	-0.3	-0.3	0.2	-0.7	-0.9
Gout (self-reported)	0.2	0.3	1.0	0.5	0.2	-1.0	-0.3	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	1.2	0.1	0.6	-0.2	0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.1	0.4	0.3	-0.7	0.6
Overall health rating	0.2	0.5	1.0	-0.6	-0.1	-1.0	0.9	0.7
Medication: Bendroflumethiazide	0.2	0.3	1.3	-0.1	-1.1	0.3	0.1	-0.5
Medication: Paracetamol	0.2	0.3	0.6	0.7	0.6	-0.8	-0.3	-0.4
Alcohol drinker status: Previous	0.2	0.2	0.5	0.2	0.2	0.4	0.7	0.6
Pack years of smoking	0.2	0.2	0.8	0.3	-0.0	0.2	0.9	0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	0.8	0.2	-0.2	0.2	-0.4	-0.9
Schizophrenia (2018)	0.1	0.2	0.4	-0.5	0.1	-0.2	0.2	-0.6
Coronary Artery Disease (CAD)	0.1	0.2	0.4	0.5	-0.6	-0.3	-0.1	0.1
Blood Red Count	0.1	0.9	2.7	-1.6	-0.5	1.2	-0.2	0.7
Tanning	0.1	0.6	1.5	-1.2	1.1	0.6	0.2	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.4	-0.3	-0.6	0.3	0.1	-0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.3	-0.5	-0.1	-0.4	-0.4
Suffer from ‘nerves’	0.1	0.2	0.8	-0.9	0.4	-0.2	0.0	-0.2
Irritability	0.1	0.2	1.1	-0.2	0.1	-1.0	-0.3	-0.1
Hair Pigment	0.0	0.5	1.0	0.6	-0.4	1.0	0.3	0.9
Medication: Atenolol	0.0	0.0	0.1	-0.0	-0.1	-0.0	0.2	-0.2
Length of working week for main job	0.0	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.0

Hub : Genes

FNDC3B

Models

Trait associations