Hub : Genes

NCEH1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0940 0.0320 1.2e-03 0.020 0.026 0.012 0.024 0.019 1.5e-03 3.8e-04 1.1e-02 0.00053 1.9e-03
2 GTEx Artery Coronary 0.2240 0.0930 9.3e-03 -0.001 NA -0.009 NA -0.007 3.5e-01 NA 9.5e-01 NA 7.0e-01
3 GTEx Artery Tibial 0.1205 0.0328 3.0e-06 0.054 NA 0.094 NA 0.088 4.4e-05 NA 8.2e-08 NA 2.2e-07
4 GTEx Esophagus Muscularis 0.1410 0.0490 1.0e-03 0.056 NA 0.077 NA 0.060 2.5e-04 NA 2.1e-05 NA 1.5e-04
5 GTEx Muscle Skeletal 0.2099 0.0441 4.6e-11 0.138 NA 0.158 NA 0.165 1.9e-13 NA 2.7e-15 NA 5.9e-16
6 GTEx Pancreas 0.2000 0.0700 3.8e-03 -0.001 NA -0.007 NA -0.005 3.7e-01 NA 9.2e-01 NA 6.0e-01
7 GTEx Skin Sun Exposed Lower leg 0.0900 0.0300 2.1e-04 0.098 NA 0.080 NA 0.094 1.7e-08 NA 3.5e-07 NA 3.6e-08
8 GTEx Thyroid 0.1020 0.0400 2.1e-03 0.055 NA 0.036 NA 0.045 4.9e-05 NA 8.2e-04 NA 2.3e-04
9 TCGA Breast Invasive Carcinoma 0.0389 0.0149 1.4e-04 -0.001 0.016 0.010 NA 0.003 4.5e-01 2.8e-04 3.7e-03 NA 6.5e-02
10 TCGA Head and Neck Squamous Cell Carcinoma 0.0812 0.0322 7.0e-05 0.055 0.042 0.040 NA 0.059 7.9e-07 1.6e-05 2.5e-05 NA 3.1e-07
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0494 0.0189 3.9e-05 0.035 0.039 0.034 NA 0.035 7.1e-05 2.8e-05 9.1e-05 NA 7.5e-05
12 TCGA Lung Adenocarcinoma 0.0292 0.0158 9.5e-03 0.019 0.015 0.005 NA 0.007 2.2e-03 6.2e-03 8.0e-02 NA 4.9e-02
13 TCGA Lung Squamous Cell Carcinoma 0.0753 0.0279 9.3e-05 0.016 0.036 0.015 NA 0.017 5.6e-03 4.8e-05 6.3e-03 NA 4.1e-03
14 TCGA Ovarian Serous Cystadenocarcinoma 0.1150 0.0530 4.6e-03 0.021 0.015 0.020 NA -0.003 1.4e-02 3.3e-02 1.5e-02 NA 5.8e-01
15 TCGA Pancreatic Adenocarcinoma 0.1180 0.0550 7.2e-03 0.065 0.037 0.038 NA 0.012 1.0e-03 1.1e-02 1.0e-02 NA 9.9e-02
16 TCGA Skin Cutaneous Melanoma 0.5470 0.1580 9.6e-03 -0.010 0.007 -0.005 NA -0.007 7.9e-01 2.1e-01 4.7e-01 NA 5.5e-01
17 TCGA Thyroid Carcinoma 0.0390 0.0180 3.8e-03 0.046 0.020 0.012 NA 0.027 2.6e-05 3.9e-03 2.0e-02 NA 1.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 2.7 4.3 8.4 -2.6 0.9 2.4 1.6 2.7 1.1 2.2 2.7 2.0 1.8 2.9 2.0 0.9 0.4 2.8 1.8 2.4
Bipolar Disorder or Schizophrenia 3.0 7.3 15.2 -3.3 1.1 3.3 2.3 3.6 0.4 2.9 3.9 2.8 1.7 3.5 2.4 -0.3 1.0 2.5 2.7 3.9
Depressed Affect (Nagel 2018) 0.6 1.2 4.0 -0.6 0.1 1.3 1.6 1.6 -0.4 0.8 1.6 0.7 -0.3 0.8 1.0 -0.5 1.3 -0.2 2.0 1.5
Depression (Nagel 2018) 0.4 0.7 2.2 -0.2 0.8 0.9 0.9 0.7 0.7 1.0 1.1 -0.1 0.6 0.7 1.5 1.0 0.5 0.0 0.6 1.0
Intelligence (Savage-Jansen 2018) 0.1 0.5 2.5 1.2 1.1 0.2 0.1 0.4 0.1 0.3 0.4 -0.7 0.0 0.2 -0.6 -0.9 1.6 -0.6 0.0 0.2
Neuroticism (Nagel 2018) 1.1 2.6 5.1 -1.5 1.1 2.0 2.3 2.1 1.3 1.7 2.1 1.4 1.0 1.4 1.9 0.6 1.8 0.3 1.8 1.9
Schizophrenia (2018) 1.7 3.6 9.5 -2.3 0.7 2.3 1.7 2.5 -0.2 1.9 2.8 1.7 0.7 2.2 1.6 -1.3 0.9 1.1 2.4 3.1
Schizophrenia vs Biploar Disorder 0.3 0.4 1.3 0.2 -0.7 0.2 1.1 0.5 -1.0 0.0 0.7 0.6 -0.5 -0.1 0.0 -0.8 0.0 -0.9 0.1 0.7
Worry (Nagel 2018) 1.4 2.9 7.2 -1.3 1.8 1.6 2.7 1.8 1.2 1.5 1.8 1.2 1.1 1.6 2.2 1.5 2.4 1.0 1.5 1.6
Alzheimer’s Disease (in mother) 0.5 0.5 2.4 -0.9 0.0 0.2 0.2 0.2 1.2 -0.3 0.8 -0.5 -0.6 0.2 0.1 -1.4 1.5 0.1 0.6 0.7
Alzheimer’s Disease (in father) 0.6 0.7 4.3 -0.7 -0.3 -0.1 -0.3 -0.1 1.3 -0.4 0.4 0.7 0.2 0.3 0.3 -2.1 -0.3 -1.2 1.6 0.7
Alzheimer’s Disease (including proxy) 0.7 1.0 4.2 -1.2 -0.2 0.3 -0.3 0.2 1.8 0.1 0.7 -0.3 -0.0 0.3 0.2 -2.0 1.8 -0.6 1.6 0.8
Crohns Disease (2017) 0.4 0.9 2.7 -0.5 1.0 1.1 1.6 0.9 0.6 0.7 1.1 1.3 -1.2 0.8 1.1 0.0 -0.3 1.0 0.8 1.1
Irritable Bowel Disease (IBD) 0.4 0.9 5.2 -0.3 -0.2 0.9 1.1 0.7 -0.2 0.5 0.9 1.4 -0.8 0.7 1.0 1.3 -0.4 2.3 0.7 0.7
Ulcerative Colitis (UC) 0.7 1.3 9.3 0.1 -1.0 0.7 0.7 0.5 -0.6 0.3 0.6 1.5 -0.1 0.7 0.8 2.3 -0.5 3.1 0.2 0.3
Major Depression (MDD) 0.3 0.3 1.5 0.3 0.1 0.0 -1.1 -0.3 -1.2 -0.2 -0.1 0.6 1.2 -0.1 -0.3 -0.1 -0.1 0.4 0.4 -0.2
Reaction Time 0.4 0.8 5.3 -1.2 1.2 -0.4 0.4 -0.8 0.3 -0.1 -0.4 -0.5 -0.1 -0.1 0.9 2.3 1.5 1.1 0.2 -0.5
Verbal and Numeric Reasoning (VNR) 0.3 0.6 6.8 0.1 1.0 -0.3 -0.0 -0.1 0.8 -0.3 0.1 -0.8 0.2 0.0 -0.6 -0.7 2.6 -0.9 0.1 -0.1
Breast Cancer 1.6 3.9 10.0 1.9 0.6 -2.3 -2.8 -3.0 -0.1 -1.2 -3.2 -1.7 1.4 -2.1 -1.4 1.0 1.9 -0.5 -1.6 -3.1
Ovarian Cancer 0.7 0.9 1.9 1.4 -0.3 -1.1 -0.9 -1.1 -0.0 -1.1 -1.2 -0.7 -1.0 -1.3 -0.8 -0.2 1.0 -0.6 -0.9 -1.0
Prostate Cancer 0.9 1.3 7.5 0.2 -1.1 -0.3 -1.0 -0.6 -0.0 -0.6 -0.7 0.0 -0.9 -1.1 -2.0 -0.6 -2.7 -0.6 -1.9 -0.6
Age at First Birth 0.4 0.6 2.9 0.5 -0.7 0.0 -0.8 0.1 0.4 0.2 -0.0 -1.6 0.2 -0.3 -1.1 -0.7 -1.7 -1.0 -0.9 0.0
Bipolar Disorder (2011) 0.4 0.4 2.5 -1.5 1.6 -0.1 0.7 0.0 -0.3 -0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0
Body Mass Index (BMI) (2010) 1.9 2.7 5.9 1.6 1.1 -2.4 -0.7 -2.0 -1.4 -2.4 -1.4 -2.4 -1.3 -2.1 -1.7 -1.2 0.6 -1.5 -0.7 -1.4
Coronary Artery Disease (CAD) 0.9 1.1 3.0 -0.3 -0.8 -1.1 -0.8 -1.0 -1.0 -1.2 -1.0 -0.1 -1.3 -1.1 -1.7 -0.5 -1.3 0.5 -1.5 -0.9
Crohns Disease (2012) 0.2 0.4 1.9 0.5 0.2 0.1 0.3 -0.1 -0.7 -0.2 -0.1 0.9 -1.4 -0.5 0.2 -0.1 -0.9 1.3 0.5 -0.1
Mean Putamen Volume 0.3 0.3 1.1 1.0 0.1 0.1 0.2 -0.2 0.0 0.3 -0.3 0.7 -0.3 0.2 1.1 -0.2 1.0 -0.1 0.9 -0.1
Fasting Glucose 0.3 0.4 1.8 0.1 0.8 -0.2 0.3 -0.3 0.5 0.0 -0.9 0.2 0.7 -0.3 0.2 1.1 0.7 1.4 0.1 -1.0
HbA1C 1.1 1.3 6.4 1.3 -0.5 -0.1 -0.9 -0.3 1.1 0.5 -0.6 0.1 1.6 -0.0 0.4 2.5 1.7 1.5 -1.0 -1.2
HDL Cholesterol 0.2 0.4 2.6 0.8 0.5 0.4 0.5 -0.2 -1.6 0.7 -0.0 -0.1 0.1 0.1 0.6 1.2 -0.1 -0.8 -0.1 0.1
LDL Cholesterol 0.5 0.7 2.5 0.1 -0.3 -0.4 -1.4 -0.5 0.3 -0.3 -1.2 -1.1 -0.9 -0.9 -1.3 -0.3 0.2 -0.5 -1.6 -0.9
Lupus 0.7 1.1 3.3 -1.5 1.2 0.8 1.2 0.6 1.8 1.0 0.9 0.4 0.9 1.2 1.4 0.8 0.6 -0.3 0.9 1.3
Neuroticism (2016) 3.8 5.5 11.7 -1.5 0.9 3.2 2.1 3.1 -0.2 3.0 3.4 2.2 1.3 3.2 2.9 0.8 2.2 1.5 2.0 3.0
Primary Biliary Cirrhosis 1.2 1.8 7.5 -2.3 0.3 0.6 1.3 0.6 0.6 0.3 1.7 1.3 0.3 1.2 1.4 -1.1 1.4 -0.0 2.7 1.8
Rheumatoid Arthritis 0.3 0.4 1.5 0.8 -1.2 -0.2 -0.8 -0.0 0.5 -0.4 -0.2 -0.2 -0.0 -0.2 0.3 0.3 1.2 1.1 0.7 -0.0
Schizophrenia (2014) 2.0 4.4 9.9 -2.2 -0.9 2.4 1.7 2.8 -0.7 2.0 3.0 2.3 1.3 2.5 2.0 -0.3 0.3 2.1 2.5 3.1
Triglycerides 0.5 0.8 2.9 -1.7 -0.1 0.5 0.5 0.9 1.6 0.1 1.0 0.9 -1.2 0.9 0.3 -0.8 0.7 0.7 0.2 1.2
Type 2 Diabetes (T2D) (2012) 0.5 0.6 3.5 0.8 -0.8 -0.4 -0.3 -0.4 0.8 -0.4 -0.4 -0.9 -0.1 -0.6 -1.4 0.3 -0.9 -0.2 -1.9 -0.6
Ulcerative Colitis 0.7 1.0 8.5 -0.4 -1.2 0.7 -0.1 0.7 -0.2 0.6 0.2 0.8 0.5 0.6 0.6 1.8 -0.4 2.9 -0.6 0.0
Blood Eosinophil Count 0.1 0.9 3.9 2.0 0.4 -0.4 1.7 -0.0 -1.6 -0.6 0.5 1.4 -1.1 0.1 -1.1 -0.2 0.6 0.1 -0.4 0.4
Blood Platelet Count 0.3 3.0 15.7 0.4 -4.0 -1.7 -1.8 -1.7 -1.5 -1.9 -0.9 0.5 -1.8 -1.2 -1.0 -0.8 1.4 2.8 1.5 -1.3
Blood Red Count 0.3 3.1 6.5 2.0 0.4 -2.2 -0.9 -2.2 -1.1 -1.8 -2.0 -1.1 -1.8 -1.9 -2.1 -1.5 -1.3 -2.5 -1.7 -1.7
Blood White Count 0.1 1.1 6.8 2.6 -0.6 -0.9 0.9 -1.1 -2.1 -0.8 -0.3 -0.4 -0.4 -0.6 -0.4 1.2 -0.2 0.9 -0.6 -0.3
Heel T-Score 0.1 0.4 1.9 0.9 1.4 0.5 0.9 -0.1 -0.3 0.8 -0.2 0.4 0.1 0.5 0.9 1.1 -0.0 -0.1 -0.0 0.0
BMI 1.3 7.8 19.2 3.6 0.3 -3.4 -2.1 -3.2 -1.1 -3.2 -2.7 -2.3 -1.6 -3.4 -4.4 -1.2 -2.8 -2.5 -3.5 -2.8
Height 0.7 12.9 71.4 -5.2 5.5 1.5 2.2 2.6 8.4 0.2 3.4 4.4 -0.5 2.7 2.2 -2.9 0.5 2.2 3.1 3.0
Waist Hip Ratio (WHR) 0.4 1.9 6.5 -0.3 -1.2 -1.2 1.3 -1.0 1.3 -2.1 0.1 1.6 -2.4 -0.3 -0.1 -1.2 1.3 1.7 2.5 -0.0
Systolic Blood Pressure 0.5 2.6 6.0 0.1 1.1 -2.1 -1.4 -2.0 -0.4 -1.7 -2.3 -2.3 -1.0 -2.2 -2.0 0.1 1.9 -0.3 -0.7 -2.4
Smoking Status 0.7 1.8 12.8 -1.4 0.6 -1.7 -0.0 -1.3 0.2 -2.3 -0.5 -0.5 -3.6 -0.7 -0.9 -0.6 1.1 -0.1 -1.2 -0.4
Allergy or Eczema 1.4 3.6 8.2 -1.4 0.7 2.0 2.9 2.8 1.6 1.4 2.3 2.8 0.1 2.3 1.5 -0.8 0.7 1.8 2.1 2.1
Cardiovascular Disease 0.2 0.5 3.4 0.4 0.7 -0.5 0.4 -0.8 -1.8 -0.6 -0.2 -0.6 -0.7 -0.5 -0.6 0.0 -0.8 -0.7 -0.9 0.0
Hypothyroidism (self reported) 0.4 0.9 4.6 -0.4 1.5 1.3 0.4 1.2 -0.3 1.1 0.8 -0.0 0.1 0.8 -0.3 -2.1 0.0 -0.6 1.1 0.9
Respiratory disease 0.4 0.9 3.3 -1.6 0.7 -0.7 0.2 -0.7 1.8 -1.1 -0.2 -0.5 -0.7 -0.7 -0.7 -1.8 0.0 -1.3 0.4 0.0
Type 2 Diabetes (T2D) (2018) 0.7 1.3 2.6 0.1 1.6 -1.5 -0.5 -1.4 0.2 -1.5 -1.4 -0.6 -0.3 -1.2 -1.5 -1.0 1.6 -0.4 0.7 -1.3
Lung FEV1/FVC ratio 0.1 0.4 1.8 -0.0 -0.0 0.3 -0.7 0.3 -1.3 0.4 -0.1 0.7 0.7 0.2 0.1 0.6 -1.3 0.1 -0.9 0.2
Lung FVC 0.1 0.7 3.0 0.1 -1.7 0.0 -0.4 0.4 -1.1 -0.0 -0.5 0.7 0.7 0.2 1.3 1.0 0.3 1.5 0.9 -0.5
Neuroticism 1.5 3.7 10.8 -1.2 1.0 2.3 3.3 2.6 1.1 2.1 2.6 1.4 0.9 1.8 2.3 1.0 1.6 1.1 1.7 2.4
Chronotype (morning person) 0.7 1.5 8.1 -2.2 2.9 -1.1 -0.6 -1.1 -1.1 -0.8 -1.4 -0.7 -0.8 -0.4 -0.0 -0.1 1.3 1.0 0.2 -1.4
Hair Pigment 0.0 0.3 1.4 -0.6 -0.2 -0.2 -0.3 -0.2 -0.4 -0.2 -0.4 -0.9 -0.3 -0.4 -0.5 -0.1 -0.5 -0.6 -1.2 0.0
Tanning 0.1 1.2 5.4 -0.4 1.8 -0.9 0.8 -0.6 -2.3 -0.9 -0.6 -1.2 -1.8 -1.1 0.5 -0.2 0.1 0.5 1.6 -0.1
Hand grip strength (left) 0.4 1.1 10.5 -0.3 3.2 0.5 0.4 0.4 1.6 0.5 0.1 0.5 0.6 0.3 -0.1 -0.6 -1.7 0.5 0.2 0.4
Number of treatments/medications taken 1.6 2.9 6.2 -2.5 1.8 1.7 2.1 1.8 -0.5 1.7 1.8 2.5 0.8 2.1 1.5 -0.7 0.9 -0.3 2.4 1.7
Average weekly spirits intake 0.7 0.8 2.6 1.6 -0.7 1.5 0.9 1.2 -1.4 1.2 1.2 0.2 -0.1 0.5 0.1 -0.2 -0.7 0.2 1.0 0.5
Sensitivity / hurt feelings 0.3 0.6 1.7 -0.3 0.8 0.8 0.9 0.8 0.6 0.8 0.6 0.8 0.2 0.3 1.2 -0.0 1.3 0.2 0.7 0.6
Frequency of depressed mood in last 2 weeks 1.5 2.1 4.5 -1.1 1.1 1.9 1.9 2.1 1.5 1.9 1.9 0.5 0.5 1.6 1.7 0.5 1.1 0.7 1.1 1.6
Hearing difficulty/problems: Yes 0.6 0.8 2.5 1.4 -1.3 -0.1 -0.6 0.1 0.6 0.2 -0.8 -0.7 0.0 -0.8 -1.2 -0.2 -1.2 -1.3 -1.6 -1.0
Relative age of first facial hair 0.3 0.5 3.0 -0.4 -1.1 0.5 0.5 0.7 1.2 0.3 0.8 -0.1 0.4 0.6 0.7 -0.2 1.7 -0.2 0.5 0.7
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.2 -0.9 -0.2 0.2 1.1 0.9 -1.4 0.2 -0.1 -0.1 -0.2 0.3 0.4 -1.5 -0.2 -0.7 1.5 0.1
Ever used hormone-replacement therapy (HRT) 1.6 2.0 7.3 -1.5 -0.6 1.1 1.7 1.4 -0.6 1.0 1.5 2.7 -0.4 1.7 2.0 -0.1 0.6 1.5 1.2 1.7
Ever had hysterectomy (womb removed) 0.6 0.7 2.0 1.0 -1.4 -0.9 -1.3 -0.9 -0.4 -0.8 -0.8 0.4 -0.3 -0.7 -0.3 -1.0 0.4 -1.1 0.1 -0.7
Systolic blood pressure, automated reading 1.6 4.7 11.4 1.4 0.9 -3.1 -2.0 -3.1 -1.0 -2.7 -3.3 -2.0 -1.5 -2.7 -2.5 0.2 0.8 -0.2 -1.7 -3.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 5.0 -0.1 2.2 0.0 0.5 -0.4 1.1 0.2 -0.6 -0.5 -0.9 -0.3 0.1 -1.0 0.3 -1.6 1.2 -0.3
Angina 0.6 0.8 4.6 0.7 0.7 -0.3 -0.0 -0.2 -1.2 -0.3 -0.6 -0.1 -0.6 -0.8 -0.8 -2.1 -1.6 -0.6 0.7 -0.6
Medication for hormone replacement therapy 1.2 1.3 7.5 1.2 -2.1 -0.4 -1.1 -0.5 -0.6 -0.1 -1.0 -0.3 0.8 -0.7 -0.9 1.0 -2.7 0.1 -1.4 -1.1
Vitamin and mineral supplements 0.4 0.5 4.7 -0.8 0.9 -0.8 -0.1 -0.6 2.2 -0.5 -0.2 -0.5 0.5 -0.3 -0.3 0.5 0.4 -0.1 -0.8 -0.5
Supplements: Zinc 0.6 0.6 3.1 0.1 0.0 0.7 0.9 0.3 -0.2 1.0 0.2 1.3 0.1 0.6 1.8 1.5 -0.9 0.4 0.0 0.5
Medication: Co-codamol 0.4 0.4 1.6 0.3 -1.3 0.6 0.2 1.1 -0.2 0.6 0.4 -0.0 0.5 0.1 0.8 -0.8 0.4 -1.1 0.4 0.4
Medication: Metformin 0.8 1.2 3.5 1.2 -0.4 -1.2 -1.4 -1.6 -0.8 -0.9 -1.9 -0.3 -0.9 -1.3 -1.2 -0.9 0.1 -0.4 -0.3 -1.6
Diabetes (father) 1.3 1.6 4.4 0.1 -0.2 -1.5 -0.5 -1.9 -0.4 -1.5 -1.7 0.9 -1.3 -1.3 -0.0 2.1 0.3 1.7 -1.2 -1.5
Diabetes (mother) 1.9 2.4 4.9 0.3 -1.1 -2.2 -2.2 -2.0 -0.9 -2.0 -2.1 -1.5 -1.2 -1.7 -1.1 0.8 -0.3 0.6 -2.0 -1.8
Severe depression (siblings) 3.2 3.6 10.8 -2.1 -0.0 2.8 1.6 3.3 1.7 2.5 2.3 1.3 0.6 2.0 1.6 -1.5 -1.0 -0.1 1.5 2.5
Pack years adult smoking proportion 0.8 1.1 3.5 0.5 -0.2 1.2 1.9 1.6 0.6 0.9 1.8 0.4 -0.2 1.2 0.5 -0.1 1.1 -0.2 0.5 1.9
Impedance of leg (right) 0.4 2.0 5.6 -0.6 -1.7 1.3 -0.1 0.5 -0.7 1.8 0.5 0.5 1.4 1.1 2.4 2.2 1.9 1.6 2.0 0.3
Leg fat-free mass (left) 0.5 2.6 10.9 -0.3 3.3 -0.6 0.2 0.2 3.0 -1.3 0.6 0.6 -0.6 -0.3 -1.8 -2.9 -2.6 -0.9 -1.1 0.5
Trunk fat percentage 0.4 1.7 4.6 1.8 0.8 -1.3 -0.3 -1.1 -0.6 -1.6 -0.7 -0.5 -1.2 -1.3 -2.2 -0.8 -2.1 -1.1 -2.0 -0.8
Hand grip strength (right) 0.6 1.6 6.6 -0.3 2.6 1.3 1.0 1.4 1.6 1.2 1.0 1.6 -0.3 1.1 0.8 -1.4 -0.6 0.7 1.6 1.2
Townsend deprivation index at recruitment 2.8 3.9 8.7 -1.9 -0.0 2.5 2.4 2.8 1.6 2.1 2.9 2.9 -0.1 2.3 1.9 0.3 0.5 1.6 0.6 2.6
Current tobacco smoking 0.7 1.2 5.2 1.1 -0.1 -1.1 -0.4 -1.1 -0.5 -1.2 -0.5 -0.4 -1.6 -0.8 -1.9 0.4 -0.8 -0.6 -2.3 -0.8
Average weekly fortified wine intake 0.2 0.3 2.0 -0.1 -0.1 0.4 0.4 0.4 0.8 0.5 0.4 0.4 1.4 0.4 -0.1 0.7 -0.4 -0.4 -0.2 0.1
Maternal smoking around birth 1.0 1.4 5.2 -0.4 -1.9 0.4 1.5 0.8 0.3 -0.2 1.1 2.3 -0.6 0.8 0.8 -1.3 0.9 -0.4 2.3 1.1
Fed-up feelings 1.2 2.2 7.4 0.6 0.9 1.5 2.2 1.9 -0.3 1.2 1.9 0.9 0.8 1.0 1.1 -0.1 2.7 -0.6 2.3 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.3 3.8 -0.2 0.7 1.2 1.2 1.1 0.2 1.1 1.3 0.4 0.5 0.9 1.9 1.2 1.4 1.1 1.5 1.3
Relative age voice broke 0.7 1.1 3.7 -0.5 -1.2 0.3 0.8 0.5 1.1 0.5 0.4 1.6 0.6 0.8 1.8 0.5 1.9 0.6 1.7 0.5
Taking other prescription medications 0.5 0.8 2.4 -0.9 1.0 1.1 0.8 0.9 -0.1 1.3 0.7 1.5 0.9 1.0 0.5 -0.8 -0.5 -0.6 0.7 0.6
Age when periods started (menarche) 0.6 1.4 4.6 -1.8 -0.3 1.6 0.8 1.0 -0.2 2.1 0.6 1.4 1.0 1.6 1.4 1.1 1.2 0.5 0.5 0.6
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.7 0.4 -0.2 -0.4 1.2 0.3 -1.0 -0.7 0.6 0.6 -1.6 -0.1 -0.6 -0.7 -0.5 -0.2 -1.1 0.6
Heel bone mineral density (BMD) T-score, automated (left) 1.9 4.4 10.8 1.9 -0.5 -2.5 -2.1 -2.8 -2.0 -1.9 -3.3 -2.7 -0.5 -2.8 -1.8 0.4 -0.9 -1.4 -1.7 -2.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 2.5 0.5 -0.5 -0.1 -0.3 -0.2 1.6 0.2 -0.4 0.5 0.5 -0.3 0.6 -0.3 -0.1 -0.2 0.6 -0.4
Qualifications: CSEs or equivalent 0.2 0.3 1.3 0.6 -0.1 -0.0 -0.5 -0.2 1.1 0.1 -0.2 -0.6 0.2 -0.3 -1.1 -0.6 -0.3 -0.3 -0.6 -0.3
Serious illness, injury or assault to yourself 2.5 3.0 7.3 -1.8 -1.1 2.4 1.6 2.7 -0.3 2.1 2.6 1.0 1.2 1.8 1.5 -1.0 0.1 -0.3 2.0 2.6
High blood pressure 0.9 2.5 6.4 0.3 0.8 -2.3 -0.3 -2.4 -1.9 -2.5 -1.6 -1.5 -1.8 -1.9 -1.5 -0.5 -0.9 -0.4 -1.4 -1.6
Hayfever, allergic rhinitis or eczema 3.1 6.7 18.1 -1.8 0.7 3.3 3.5 4.2 1.8 2.8 3.3 2.8 0.8 3.2 2.5 -0.6 1.1 1.5 2.6 3.2
Multivitamins +/- minerals 0.6 0.8 3.3 1.0 -1.7 0.0 -0.8 -0.0 -1.8 -0.1 -0.2 0.6 -0.4 -0.3 -0.3 -1.7 -0.8 -0.6 1.0 0.2
Stomach or abdominal pain in last month 5.0 6.2 12.6 -1.9 0.6 3.3 2.5 3.5 0.6 3.1 2.8 2.6 0.4 3.0 3.1 1.4 2.9 2.4 2.3 2.7
Supplements: Glucosamine 0.3 0.4 3.7 -0.6 -0.4 -0.1 0.4 0.2 -1.9 -0.4 0.7 1.1 -0.1 0.4 -0.1 -0.5 0.3 -0.2 0.3 0.6
Diverticular disease/diverticulitis (self-reported) 0.6 0.7 4.3 0.3 -0.2 -0.3 0.1 -0.4 -1.3 -0.9 0.3 -0.6 -2.1 -0.0 -0.6 -1.5 0.8 -0.0 1.1 0.2
Medication: Atenolol 0.4 0.5 1.8 0.3 1.1 -0.1 -0.7 -0.5 0.1 0.3 -0.8 -0.2 1.3 -0.3 0.0 -0.0 0.5 -0.9 1.3 -0.6
Medication: Levothyroxine sodium 0.4 0.7 3.1 -0.9 1.1 -0.1 -0.2 -0.2 -1.5 0.2 -0.8 -0.3 -0.1 -0.1 -0.4 -1.8 -1.0 -1.1 1.4 -0.5
Sitting height 0.3 2.4 13.4 -0.8 3.0 0.3 0.2 0.9 3.0 -0.3 0.9 1.2 0.2 0.4 -0.5 -3.7 -0.7 -0.4 1.9 0.8
Chronic bronchitis/emphysema (father) 1.0 1.2 11.2 0.2 0.9 0.2 0.5 0.3 0.5 0.6 -0.1 -1.0 -0.4 -0.3 -1.2 -2.2 -0.0 -3.4 -0.3 -0.2
High blood pressure (mother) 0.8 1.1 5.0 0.5 2.2 0.6 0.1 0.1 -1.2 1.4 -0.5 -1.1 1.8 0.2 -0.4 0.8 -1.4 -0.7 -1.7 -0.2
Body mass index (BMI) 1.1 4.7 11.7 3.2 0.5 -2.5 -1.3 -2.1 -0.8 -2.6 -1.8 -2.0 -1.3 -2.6 -3.4 -0.8 -2.4 -1.6 -3.2 -1.8
Impedance of leg (left) 0.4 2.0 6.1 -0.7 -1.7 1.4 0.1 0.9 -0.3 1.9 0.9 0.5 1.0 1.2 2.3 1.9 2.5 1.1 2.0 0.8
Leg predicted mass (left) 0.5 2.6 11.0 -0.4 3.3 -0.6 0.2 0.3 3.0 -1.3 0.6 0.7 -0.7 -0.3 -1.8 -2.9 -2.6 -0.8 -1.0 0.6
Trunk fat mass 0.5 2.2 7.0 1.6 1.7 -1.5 -0.4 -1.1 0.4 -1.9 -0.6 -0.4 -1.2 -1.4 -2.5 -1.3 -2.6 -1.0 -2.0 -0.8
Waist circumference 0.6 2.3 6.3 1.9 1.5 -1.7 -0.1 -1.4 1.1 -2.4 -0.7 -0.2 -1.8 -1.5 -2.5 -1.9 -1.5 -0.9 -1.3 -0.8
Number of incorrect matches in round 0.6 1.0 5.7 -2.4 0.6 0.8 0.5 1.0 0.3 0.6 0.9 -0.1 -0.6 0.8 -0.1 -1.5 -1.2 -1.4 0.1 0.9
Past tobacco smoking 0.8 1.4 5.8 2.4 -0.7 -0.5 -0.9 -0.5 -0.5 0.2 -1.3 -1.0 1.7 -0.9 -1.0 -0.4 -1.6 -1.8 -0.8 -1.1
Alcohol usually taken with meals 1.1 1.9 5.9 -2.3 1.2 0.8 1.3 1.0 -0.7 0.8 0.8 2.4 0.8 1.7 1.6 -0.1 -0.0 1.7 2.0 1.0
Nervous feelings 1.1 2.0 4.9 -1.0 0.3 1.5 1.9 1.8 0.8 1.1 2.2 0.7 1.6 1.6 1.4 0.2 0.6 0.5 1.9 2.1
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 3.5 1.9 0.5 0.7 0.7 0.4 1.2 1.1 0.5 -0.5 1.2 0.2 -0.2 1.2 -0.2 0.3 -0.5 -0.1
Hearing difficulty/problems with background noise 0.4 0.7 2.1 -0.3 -0.6 1.1 0.8 1.2 1.5 0.7 1.0 0.2 0.2 0.8 0.2 -0.7 0.1 -1.2 -0.0 1.1
Hair/balding pattern: Pattern 2 0.2 0.3 2.0 0.3 -0.9 -0.2 -0.2 0.2 0.7 -0.2 -0.2 -0.4 0.1 0.1 -0.6 -1.0 0.3 -1.4 -0.1 0.1
Had menopause 0.2 0.3 1.4 0.4 -0.8 -0.4 -0.2 0.0 -0.7 -0.4 0.0 0.1 -0.6 0.0 0.2 -0.5 0.4 -1.2 0.6 -0.2
Had other major operations 2.7 3.3 9.0 -1.7 -0.6 1.9 2.7 2.6 -0.7 1.0 3.0 1.7 0.3 2.0 1.3 -1.0 1.1 0.7 2.8 2.3
Forced vital capacity (FVC) 0.3 1.2 3.7 -1.6 1.4 0.7 0.4 1.3 0.6 0.3 1.0 1.2 -0.0 1.0 0.8 -1.9 0.4 1.0 1.7 1.1
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 12.3 2.2 -0.1 -2.3 -1.9 -2.9 -1.8 -1.6 -3.5 -2.5 -0.2 -2.7 -1.8 0.8 -1.4 -1.2 -1.7 -3.0
Ever unenthusiastic/disinterested for a whole week 0.1 0.2 1.3 -0.2 -1.1 -0.1 -0.1 -0.2 -0.4 -0.3 0.3 0.3 0.4 0.2 0.2 -0.3 0.0 0.3 0.6 0.1
Qualifications: None of the above 0.3 0.6 2.1 0.5 0.6 -0.5 0.7 -0.4 1.1 -0.9 0.1 -0.1 -1.4 -0.5 -0.3 -0.3 0.9 -1.4 0.8 0.1
Financial difficulties in last 2 years 1.7 2.2 5.9 -1.3 -0.4 2.0 1.1 2.4 1.0 1.8 2.3 0.7 1.3 2.1 1.0 0.3 -0.5 1.5 0.5 2.2
Mouth/teeth dental problems 0.3 0.5 1.6 0.1 0.6 -0.7 0.1 -0.8 -0.7 -0.9 -0.6 -1.1 -0.8 -0.9 -0.7 -1.3 0.5 -0.7 0.4 -0.1
Heart attack 2.1 2.7 4.9 -1.8 1.9 1.9 1.5 2.2 2.0 1.8 1.6 1.3 -0.3 1.7 1.4 -1.1 1.8 0.3 2.1 1.8
Allergy 0.7 1.6 4.8 0.8 -1.0 -1.6 -1.8 -1.9 -2.2 -1.3 -1.2 -1.1 -0.3 -1.2 -0.9 1.2 0.1 0.2 -1.4 -1.3
Pain all over the body in last month 1.0 1.1 3.7 -0.5 0.6 0.9 1.9 1.1 1.5 0.1 1.8 0.2 -0.1 1.0 0.9 -0.5 0.3 -0.7 1.4 1.5
Diabetes (self-reported) 1.1 1.7 3.5 0.7 1.4 -1.7 -0.3 -1.9 -0.6 -1.7 -1.6 -0.4 -0.9 -1.7 -1.5 -1.5 1.6 -0.9 1.0 -1.4
Hayfever/allergic rhinitis (self-reported) 0.7 1.0 2.6 -0.7 -0.2 1.2 1.3 1.6 -0.4 0.4 1.6 0.8 0.3 1.3 0.8 -0.4 0.0 0.4 1.2 1.6
Medication: Ramipril 1.2 1.5 3.8 1.0 -0.0 -1.7 -0.4 -1.4 -0.4 -1.9 -1.3 -0.7 -1.7 -1.3 -1.7 -1.1 -0.5 -0.8 -1.8 -1.1
Medication: Simvastatin 0.5 0.7 4.4 0.1 0.2 -0.5 0.2 -0.2 -0.9 -0.4 -0.2 -0.1 -0.8 -0.4 -0.5 -1.7 1.3 -2.1 0.5 -0.1
Fluid intelligence score 0.4 0.7 4.1 0.4 -0.4 -1.0 -0.4 -0.6 -0.8 -0.6 -0.7 -0.8 0.9 -0.6 -0.6 -0.9 2.0 -1.1 0.5 -0.8
Illnesses of siblings 0.6 0.9 2.7 -0.0 1.6 1.0 0.2 0.6 -0.4 1.5 0.2 0.1 1.2 1.1 1.3 1.6 0.6 1.0 -0.1 0.2
Neuroticism score 2.0 4.1 9.9 -1.3 1.3 2.3 3.1 2.8 0.7 2.1 2.8 1.5 1.2 2.1 2.3 0.9 2.1 1.4 1.9 2.5
Weight 0.5 2.5 7.7 1.4 2.8 -1.3 -0.5 -0.7 1.8 -1.8 -0.5 -0.3 -0.7 -1.3 -2.5 -2.0 -2.6 -1.1 -1.8 -0.6
Impedance of arm (right) 0.9 4.1 8.5 -1.4 0.2 2.6 2.1 2.3 -0.6 2.8 1.8 2.7 1.6 2.6 2.9 0.7 1.8 1.9 2.0 1.9
Arm fat percentage (right) 0.9 3.5 9.1 3.0 0.7 -2.0 -0.7 -1.7 -1.5 -2.1 -1.6 -1.0 -0.8 -2.0 -3.0 -0.8 -2.3 -1.1 -2.9 -1.7
Trunk fat-free mass 0.4 2.4 11.2 -0.3 3.3 -1.0 -0.8 -0.4 3.3 -1.3 -0.2 0.0 -0.0 -0.8 -1.8 -2.3 -2.2 -0.6 -0.3 -0.3
Hip circumference 0.4 1.9 6.7 1.6 2.6 -1.1 -0.5 -0.8 0.8 -1.3 -0.5 -0.8 -0.6 -1.2 -2.2 -1.6 -2.1 -1.1 -1.9 -0.4
Time employed in main current job 1.2 1.4 3.3 1.0 -0.7 -1.3 -1.2 -1.7 -1.2 -1.0 -1.5 -1.1 -0.2 -1.4 -1.1 0.8 -0.9 -1.1 -1.8 -1.3
Alcohol intake versus 10 years previously 0.2 0.3 1.4 -0.8 0.3 0.1 0.1 0.1 -0.0 -0.2 0.4 1.1 -0.2 0.1 0.0 0.7 0.6 1.2 0.5 0.5
Father’s age at death 0.4 0.5 2.3 0.0 -0.7 -0.7 -0.5 -0.7 0.3 -0.8 -0.0 -0.5 -0.3 -0.3 -0.3 -1.0 0.7 -1.5 1.2 -0.2
Worrier / anxious feelings 1.6 3.1 6.1 -1.5 1.5 2.1 2.5 2.0 1.3 2.0 1.7 1.1 -0.0 2.0 2.3 1.4 2.4 1.5 0.7 1.9
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.0 7.3 -0.7 1.4 2.5 2.7 2.5 0.1 2.5 2.0 1.5 1.1 1.8 1.6 0.1 0.6 -0.8 2.2 2.0
Falls in the last year 0.4 0.5 1.1 -0.6 0.6 0.9 0.3 0.9 0.2 0.9 0.4 -0.3 0.5 0.5 1.1 0.9 -0.8 0.9 -0.3 0.7
Hair/balding pattern: Pattern 3 0.3 0.4 1.5 1.0 -0.0 0.6 0.1 -0.4 -1.2 0.7 0.5 0.2 -0.5 0.2 -0.1 0.8 1.2 0.4 -0.1 0.3
Number of live births 1.0 1.4 6.0 0.0 -1.3 -1.0 0.3 -0.6 1.1 -1.7 0.2 0.5 -2.5 -0.9 -0.0 -2.3 1.2 -1.5 1.0 0.3
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.1 -1.7 0.8 1.1 0.5 1.8 0.4 0.7 1.4 1.5 0.5 1.4 1.2 -1.2 0.6 1.4 1.6 1.5
Pulse rate 3.5 6.0 10.8 3.1 -1.7 -3.1 -2.0 -3.1 0.5 -2.9 -2.7 -3.0 -2.5 -3.3 -3.2 -1.6 -0.6 -1.1 -1.1 -2.8
Happiness 3.0 3.7 10.0 -1.9 1.8 1.9 2.7 1.6 -0.7 1.8 2.2 3.2 1.2 2.3 2.3 0.8 -0.7 1.9 1.5 2.1
Noisy workplace 0.8 1.0 3.8 1.8 0.3 0.1 -0.9 -0.3 -0.0 0.4 -0.9 -1.3 1.0 -0.7 -0.8 1.3 -1.4 -0.7 -1.9 -0.5
Qualifications: A levels/AS levels or equivalent 1.5 3.4 7.3 -0.7 2.0 2.3 2.7 2.4 -1.2 2.3 2.5 1.3 1.8 2.5 1.2 -0.4 1.4 0.8 1.6 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 4.2 0.8 -0.1 -0.2 0.0 -0.5 -0.1 -0.4 0.1 0.0 -0.7 0.1 0.3 0.2 -0.5 -0.1 -2.0 0.3
Mouth/teeth dental problems: Dentures 0.6 1.1 3.1 0.9 -0.8 -1.0 -1.4 -0.8 0.0 -0.5 -1.4 -1.5 0.0 -0.9 -0.7 0.2 -0.5 -1.8 -1.2 -1.5
Asthma 0.6 1.3 5.4 -0.3 0.5 -1.2 -0.5 -1.4 0.5 -1.4 -0.8 -0.7 -0.9 -1.2 -1.2 -2.1 -0.5 -2.3 -0.2 -0.5
Medication: Ibuprofen (e.g. Nurofen) 3.9 5.0 12.0 -0.9 0.4 3.5 1.8 3.0 0.8 3.4 3.0 2.1 1.8 3.1 2.1 -0.4 0.9 -0.4 2.5 2.9
Medication: Cholesterol lowering 0.3 0.4 1.6 -0.5 -0.2 -0.3 0.2 -0.5 -1.3 -0.6 0.1 0.6 -1.1 -0.2 -0.8 -1.1 -0.2 -1.0 0.2 0.1
Depression (self-reported) 1.6 2.0 4.3 -2.1 -1.1 1.5 0.6 1.9 0.5 1.1 2.0 1.2 1.1 2.1 1.7 0.0 0.1 1.2 0.8 2.0
Medication: Lansoprazole 0.7 0.8 3.3 0.0 -1.7 0.1 0.1 0.1 -1.8 -0.4 0.8 0.9 -1.6 0.0 0.2 -0.9 1.3 0.0 0.7 0.8
Prospective memory result 0.2 0.3 1.7 0.3 -0.5 0.1 -0.6 -0.7 1.3 0.0 0.0 0.6 0.6 -0.3 -0.3 0.3 -0.6 -0.2 0.3 -0.1
Lung cancer (father) 0.6 0.7 1.5 0.0 -0.9 -1.0 -1.1 -0.8 0.6 -0.8 -1.2 -0.1 -0.9 -0.8 -0.4 -0.7 -1.0 0.8 -0.8 -1.0
Illnesses of mother 0.6 0.8 3.0 -0.8 -1.7 0.1 0.2 0.3 0.7 0.1 0.3 0.9 0.5 0.3 1.2 1.7 0.7 1.6 0.6 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.9 2.8 6.3 -2.0 -0.2 1.7 0.9 2.5 0.6 0.9 2.3 1.8 0.6 1.9 1.9 -1.2 1.1 1.9 2.1 2.3
Pulse wave Arterial Stiffness index 0.6 0.7 3.7 -0.0 0.8 0.2 -0.1 0.2 0.1 0.2 0.3 -1.8 -0.9 -0.2 -0.2 -1.7 0.5 -1.9 -0.0 0.5
Impedance of arm (left) 1.0 4.5 8.9 -1.6 -0.4 2.9 1.8 2.6 -0.7 3.0 2.2 2.5 1.6 2.9 2.9 0.7 1.9 1.7 2.1 2.2
Arm fat mass (right) 0.8 3.4 9.0 2.7 1.5 -2.1 -0.8 -1.6 -0.1 -2.4 -1.4 -0.9 -1.1 -2.1 -3.0 -1.4 -2.3 -1.1 -2.5 -1.5
Trunk predicted mass 0.4 2.3 10.9 -0.3 3.3 -0.9 -0.8 -0.3 3.2 -1.3 -0.1 0.1 -0.0 -0.8 -1.7 -2.3 -2.2 -0.5 -0.3 -0.3
Standing height 0.8 7.5 29.7 -3.5 4.6 1.9 1.4 2.5 5.5 1.3 2.6 3.4 0.9 2.3 1.5 -2.9 -0.9 1.2 2.8 2.3
Length of working week for main job 0.4 0.4 2.4 1.4 -0.3 0.4 -0.1 0.7 -0.1 0.4 0.2 -0.8 0.3 -0.1 -0.7 0.4 -1.6 -0.3 -0.8 0.1
Exposure to tobacco smoke at home 0.7 0.8 5.1 1.1 -0.4 0.1 -0.7 0.2 2.3 0.4 0.1 -0.7 0.4 -0.1 0.3 -0.1 1.4 -1.3 1.3 0.1
Breastfed as a baby 1.0 1.2 4.4 -0.8 1.0 0.3 1.6 -0.1 -1.4 0.1 0.6 1.0 0.2 0.7 2.1 1.5 0.8 1.2 1.9 0.7
Tense / ‘highly strung’ 1.2 2.0 6.3 -1.3 0.2 1.4 1.6 1.9 2.2 1.2 2.1 0.2 0.7 1.4 1.0 1.0 2.5 1.0 0.8 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 1.1 1.8 8.1 -0.4 -1.2 1.3 1.8 1.9 0.6 0.6 1.8 0.5 1.0 1.3 1.0 -0.1 1.0 0.1 2.8 1.6
Hair/balding pattern: Pattern 4 0.7 1.7 7.3 -2.7 0.3 1.5 1.2 1.6 1.0 1.1 1.8 1.2 -0.4 1.5 0.9 -1.1 -0.7 -0.6 0.4 1.7
Birth weight of first child 1.2 2.2 3.8 -0.9 0.3 1.7 1.2 1.9 2.0 1.4 1.7 1.9 1.0 1.8 1.7 -0.0 1.3 1.0 1.8 1.9
Peak expiratory flow (PEF) 0.2 0.4 1.5 -0.3 0.3 0.8 -0.0 1.2 -0.2 0.6 0.7 0.5 0.4 1.0 0.4 -0.9 0.1 0.2 0.3 1.0
Pulse wave reflection index 0.4 0.5 1.9 -0.5 -0.3 1.0 -0.1 1.1 -0.8 0.9 0.8 -1.0 0.4 0.6 0.0 -0.6 0.2 -1.4 0.1 0.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 4.3 0.8 -2.1 -0.0 -0.1 0.0 -0.8 -0.1 0.4 0.3 1.1 0.0 0.2 0.8 0.2 0.7 1.0 0.2
Loud music exposure frequency 0.5 0.5 2.9 -1.7 -1.3 0.0 0.0 0.3 1.4 -0.5 0.7 0.1 -0.7 0.2 0.2 -0.3 -0.1 0.7 -0.0 0.6
Qualifications: O levels/GCSEs or equivalent 0.5 0.9 7.3 -0.2 0.3 1.1 -0.2 0.7 -0.2 1.6 0.5 -0.1 2.7 1.0 0.5 0.5 -0.3 1.0 0.3 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.9 -0.0 -0.0 0.4 0.6 0.8 0.7 0.3 0.8 1.7 0.9 0.9 -0.0 0.9 -1.0 0.7 -0.8 0.3
Blood clot in the leg (DVT) 0.9 1.2 5.0 1.1 0.5 -0.6 -1.0 -0.7 2.2 -0.4 -1.2 -1.0 -0.5 -1.1 -0.8 -0.9 -2.2 -0.5 -1.0 -0.6
Medication: Paracetamol 1.6 2.6 5.1 -2.1 1.8 1.5 1.6 1.9 0.6 1.8 1.6 2.3 1.2 1.6 2.1 -0.2 1.4 0.2 2.2 1.6
Headache pain in last month 1.9 3.2 6.7 -1.3 -0.5 2.6 1.0 2.6 -0.1 2.5 2.3 1.2 2.1 2.1 2.0 0.7 1.1 1.0 2.2 2.3
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 2.4 1.1 -1.0 1.4 -0.4 1.5 1.2 1.5 0.6 -0.5 1.5 0.7 1.0 -0.2 -0.0 0.2 0.6 0.7
Glaucoma (self-reported) 1.1 1.3 8.8 0.5 -3.0 0.3 -1.2 -0.2 -0.9 0.7 -0.4 -0.1 -0.8 -0.2 -0.0 -1.9 1.5 -1.4 1.5 -0.1
Gout (self-reported) 0.4 0.5 2.5 0.4 0.4 -0.7 0.4 -0.7 -1.3 -0.7 -0.3 -0.1 -1.6 -0.2 0.3 0.6 1.2 0.3 0.1 0.1
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 3.6 -1.3 1.6 0.9 0.6 0.9 -1.0 0.7 0.6 0.3 -0.4 0.8 -0.0 -1.9 -0.6 -0.4 0.7 0.8
Medication: Amlodipine 2.7 3.7 8.9 -0.0 -0.6 -3.0 -1.7 -2.7 -2.4 -2.8 -2.9 -1.5 -0.9 -2.5 -1.6 0.3 -1.2 -0.4 -1.2 -2.6
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.9 -0.0 1.1 -0.3 -0.7 -0.6 0.9 0.0 -1.0 -0.5 1.0 -0.8 -0.6 -0.3 0.5 -1.4 0.1 -0.7
Birth weight 0.4 1.0 4.2 0.5 0.2 0.9 1.0 0.6 -0.7 0.7 1.0 2.0 1.2 0.9 1.0 0.5 0.8 0.6 1.7 0.5
Chronic bronchitis/emphysema (mother) 1.5 1.8 6.3 2.5 -1.6 -1.2 -0.4 -0.6 0.4 -1.4 -0.7 -1.7 -1.0 -1.5 -1.1 -2.1 0.5 -1.9 0.9 -0.7
High blood pressure (siblings) 0.7 1.0 5.4 -1.0 -2.3 -0.7 -0.2 -0.1 1.0 -1.4 0.4 0.0 -2.1 -0.4 -0.6 -0.8 -0.1 0.4 -0.7 0.3
Forced vital capacity (FVC), Best measure 0.8 2.9 6.5 -2.1 0.4 1.5 0.9 2.3 1.2 0.7 2.3 1.9 0.2 1.9 1.7 -2.0 0.7 1.6 2.6 2.3
Body fat percentage 0.8 3.1 7.8 2.7 0.4 -1.9 -1.0 -1.7 -0.9 -2.1 -1.4 -1.2 -1.2 -2.0 -2.8 -0.5 -2.3 -1.2 -2.6 -1.5
Leg fat percentage (right) 1.8 6.4 16.1 4.0 -0.4 -2.9 -2.2 -3.0 -1.2 -2.8 -2.6 -2.5 -1.2 -3.1 -3.6 0.0 -2.1 -1.4 -3.1 -2.8
Arm fat-free mass (right) 0.5 2.4 11.3 -0.4 2.7 -1.0 -0.7 -0.4 3.4 -1.5 0.1 -0.2 -0.8 -0.7 -1.8 -2.5 -2.2 -1.4 -0.8 0.1
Exposure to tobacco smoke outside home 0.2 0.3 1.8 -0.2 0.0 -0.4 -0.4 -0.1 0.5 -0.3 -0.4 -0.8 -0.0 -0.5 -0.5 -0.9 0.2 -1.3 0.1 -0.3
Comparative body size at age 10 0.1 0.2 1.1 0.2 0.1 -0.4 0.4 -0.1 -0.1 -1.1 0.5 -0.6 -1.1 0.1 -0.3 -0.0 -0.3 0.5 -0.3 0.4
Number of full brothers 0.6 0.8 4.1 -0.1 0.2 0.7 1.0 1.0 2.0 0.9 0.8 0.3 0.5 0.6 0.8 0.8 1.4 -1.2 -0.0 0.7
Worry too long after embarrassment 0.4 0.7 2.8 -0.3 0.3 0.9 1.1 0.8 1.2 0.7 1.0 0.1 0.8 0.5 0.7 1.7 1.0 0.8 -0.7 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.4 1.8 4.4 -1.6 -0.9 1.4 0.4 1.7 -0.2 1.4 1.5 1.5 1.3 1.7 1.3 0.7 0.7 2.1 1.3 1.2
Wheeze or whistling in the chest in last year 0.9 1.6 3.5 -0.7 1.0 1.6 1.5 1.1 1.4 1.3 1.7 1.2 -0.0 1.2 0.9 -0.9 0.8 -1.2 1.6 1.9
Number of children fathered 0.5 0.5 4.1 -2.0 -0.3 -0.4 -0.5 -0.8 0.2 -0.5 -0.5 0.4 -0.9 -0.3 0.2 0.0 -0.7 1.1 -0.6 -0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.8 0.9 2.7 0.7 0.7 -1.0 -0.7 -0.8 -0.7 -0.8 -1.7 -0.8 -0.4 -1.2 -1.3 0.5 -0.7 -0.2 -1.0 -1.4
Age at first live birth 0.7 1.2 5.4 -2.3 1.6 1.1 0.3 0.9 0.1 1.5 0.7 0.4 1.3 1.5 0.5 0.8 -0.2 1.6 -0.2 0.6
Pulse wave peak to peak time 0.6 0.7 4.0 -0.3 -0.4 0.0 0.1 -0.1 0.3 -0.0 -0.1 2.0 1.0 0.3 0.3 1.7 -0.5 2.0 0.2 -0.3
Health satisfaction 0.8 1.0 4.6 1.0 1.3 0.7 0.8 0.2 -0.7 0.8 0.2 0.9 1.2 0.3 0.6 1.6 -2.2 0.5 -1.2 0.4
Shortness of breath walking on level ground 0.2 0.2 0.6 0.6 0.2 -0.2 0.5 -0.1 -0.5 -0.8 0.4 0.2 -0.5 -0.3 -0.6 -0.7 -0.2 -0.2 -0.2 0.5
Qualifications: College or University degree 0.3 1.0 2.5 -0.1 0.4 1.3 0.9 1.6 -1.2 1.6 1.0 1.3 0.2 1.6 0.8 -1.1 -0.0 -0.5 0.0 1.1
Eye problems/disorders: None of the above 0.7 0.8 2.9 -0.7 0.5 0.5 0.3 0.8 -1.2 0.5 0.6 -0.5 0.7 0.7 0.7 1.7 -0.1 1.4 -1.7 0.7
Mouth/teeth dental problems: Loose teeth 1.2 1.4 4.9 1.1 -1.5 -0.8 -1.2 -0.1 1.3 -0.9 -0.2 -1.5 -1.0 -1.0 -2.0 -2.2 -0.9 -1.2 0.1 -0.7
Emphysema/chronic bronchitis 0.5 0.5 4.5 -1.0 0.3 0.4 0.3 0.4 0.3 0.1 0.5 -0.7 0.0 0.2 -0.1 0.9 -2.1 -0.5 -0.9 0.4
Medication for pain relief, constipation, heartburn 1.8 3.1 6.6 2.0 -1.2 -1.9 -1.8 -2.0 0.2 -1.8 -1.8 -2.6 -1.7 -2.1 -2.1 -0.2 -1.6 -0.0 -2.6 -1.7
Neck or shoulder pain in last month 0.7 1.1 3.7 1.9 1.5 1.1 1.0 0.5 0.2 1.4 -0.2 0.4 1.0 0.4 -0.6 0.5 -1.8 -1.4 -0.3 0.2
Medication: Blood pressure 1.2 2.1 5.6 -1.0 1.8 -2.3 0.0 -2.4 -0.9 -2.3 -1.6 0.2 -1.8 -1.3 -0.9 0.8 0.6 0.8 -0.6 -1.8
Angina (self-reported) 0.6 0.8 6.4 0.6 0.8 -0.3 0.2 -0.0 -1.1 -0.4 -0.3 0.0 -0.8 -0.6 -0.9 -2.5 -1.3 -0.6 0.8 -0.3
Migraine (self-reported) 0.9 1.1 3.8 -1.9 0.2 1.5 0.8 1.4 0.2 1.2 1.6 1.0 0.4 1.4 0.7 0.0 -0.5 -0.3 0.0 1.4
Medication: Ibuprofen 5.4 6.5 12.2 -1.6 1.2 3.5 2.5 3.4 1.0 3.2 3.5 2.2 1.6 3.4 2.8 -0.3 2.2 0.2 3.3 3.3
Medication: Allopurinol 0.4 0.5 2.3 0.9 0.6 -0.1 0.5 -0.4 -1.5 -0.1 -0.1 0.5 -0.3 0.0 0.5 1.4 -0.2 1.3 0.1 0.0
Medication: Omeprazole 1.6 1.9 4.1 -1.6 1.2 1.8 1.5 1.8 -0.5 1.6 1.4 2.0 -0.5 1.8 0.7 -1.4 -0.3 0.1 1.8 1.3
Medication: Seretide 50 evohaler 0.3 0.3 2.3 -0.1 -0.5 -0.1 -0.1 -0.4 0.3 -0.7 0.4 0.4 -0.7 -0.1 -0.6 -1.5 -0.2 -0.9 0.6 0.4
Mean time to correctly identify matches 0.3 0.5 2.6 -1.0 0.9 -0.7 0.5 -1.2 0.8 -0.5 -0.5 0.1 -0.6 -0.4 0.2 1.6 0.2 0.2 0.1 -0.8
Heart disease (mother) 0.7 0.8 4.8 -1.1 0.4 -0.3 0.2 0.0 2.2 -0.5 0.2 -0.4 -0.6 -0.2 -1.4 -0.4 -1.0 -1.2 -1.3 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.9 2.0 -0.2 -0.3 0.3 -0.5 -0.3 0.2 -0.9 -1.2 0.2 -0.6 -0.2 1.1 -1.7 -0.9 -1.1 -1.0
Whole body fat mass 0.7 2.9 7.8 2.1 1.3 -1.8 -0.7 -1.4 0.5 -2.2 -1.0 -0.7 -1.4 -1.8 -2.8 -1.4 -2.7 -1.1 -2.2 -1.1
Leg fat mass (right) 0.9 3.4 9.0 2.5 1.0 -2.2 -1.2 -1.9 0.3 -2.6 -1.3 -1.3 -1.2 -2.2 -3.0 -0.9 -2.4 -1.0 -2.4 -1.6
Arm predicted mass (right) 0.5 2.5 11.1 -0.1 2.5 -1.0 -0.9 -0.4 3.3 -1.5 0.0 -0.3 -1.0 -0.9 -2.0 -2.7 -2.2 -1.6 -0.7 -0.0
Pulse rate, automated reading 2.1 6.9 14.7 3.3 -3.3 -3.4 -3.0 -3.8 1.7 -3.1 -3.0 -2.1 -1.9 -3.4 -2.4 -1.4 -0.5 -1.0 -0.5 -3.1
Alcohol intake frequency. 0.3 0.7 3.0 1.3 -0.8 -0.5 0.1 -0.5 0.1 -0.9 0.2 -0.1 -0.7 -0.4 -0.6 -1.4 1.4 -1.7 0.8 0.3
Comparative height size at age 10 0.8 4.4 34.7 -3.7 5.9 0.7 0.2 1.1 3.5 0.3 0.8 1.7 0.7 0.8 0.7 -2.0 -0.5 0.7 1.4 0.6
Number of full sisters 2.4 3.0 6.7 -1.4 2.5 2.6 1.9 2.4 0.7 2.5 2.0 1.5 1.1 2.1 1.7 -0.3 0.2 -0.6 0.9 2.1
Suffer from ‘nerves’ 2.0 3.1 7.8 -1.4 0.6 2.0 1.5 2.1 0.6 2.0 2.1 1.3 1.6 2.2 2.2 0.1 2.8 0.7 2.1 1.9
Overall health rating 0.3 0.6 2.0 -0.5 1.4 0.8 0.8 0.6 0.3 0.8 0.4 0.8 1.1 0.5 0.1 0.2 -1.4 -0.8 0.4 0.4
Chest pain or discomfort 3.4 5.0 12.8 -1.9 2.3 3.0 3.6 3.0 1.1 2.7 3.0 1.6 -0.2 2.4 2.3 -0.4 0.8 -0.5 2.4 2.8
Had major operations 1.2 1.5 5.5 -0.2 0.6 -1.3 -0.3 -1.2 0.3 -1.6 -0.5 -1.3 -2.1 -1.1 -1.6 -2.3 -0.2 -1.8 0.5 -0.3
Age at last live birth 1.4 2.0 5.2 -1.8 0.1 2.2 -0.0 2.1 0.8 2.3 1.8 0.6 1.6 2.0 0.4 -1.0 -0.1 0.5 0.9 1.7
Family relationship satisfaction 0.8 1.0 2.6 -1.4 1.0 0.9 1.3 1.2 0.5 0.6 1.3 0.1 -0.3 1.1 0.6 -1.1 -1.6 -0.1 0.5 1.5
Leg pain on walking 1.2 1.5 3.9 -0.9 1.1 1.5 1.5 1.2 0.2 1.0 1.5 2.0 0.4 1.4 1.6 1.4 0.6 0.8 0.2 1.7
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 4.2 0.5 -0.6 -0.5 -0.8 -0.3 0.8 -0.7 -0.4 -0.3 -0.3 -0.3 -0.5 1.4 -0.4 2.1 -1.4 -0.6
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.5 -0.4 -0.7 1.0 0.2 1.2 -0.1 0.8 1.1 -0.4 0.3 0.6 -0.1 -0.3 -1.2 -0.3 0.3 1.0
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 7.2 1.3 0.3 -1.7 -2.1 -2.2 -0.2 -1.0 -2.7 -1.9 0.3 -2.1 -1.1 0.0 -0.4 -1.2 -0.4 -2.5
Medication: Aspirin 0.2 0.2 0.7 -0.2 0.7 -0.5 0.2 -0.4 -0.8 -0.5 -0.6 -0.0 0.4 -0.2 0.2 0.5 0.1 -0.1 0.7 -0.3
Supplements: Vitamin C 0.3 0.3 1.5 1.2 -0.8 0.6 0.6 0.6 0.2 0.4 0.6 0.0 -0.9 0.4 0.4 0.6 -0.3 0.6 -0.1 0.4
Knee pain experienced in last month 2.2 3.4 8.2 -1.2 0.8 2.6 1.8 2.9 1.2 2.7 2.1 2.0 2.0 2.6 1.6 0.4 -0.7 -0.7 0.6 2.4
Hypertension (Self-reported) 0.7 1.8 4.4 0.6 0.8 -2.0 -0.3 -2.1 -1.9 -2.0 -1.5 -1.1 -1.2 -1.6 -1.3 -0.0 -1.0 -0.2 -1.3 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 3.3 -0.7 -1.0 1.1 0.1 0.6 -1.0 0.5 1.1 1.8 -0.1 1.1 0.6 -0.1 0.2 0.1 1.2 0.9
Illnesses of father: Heart disease 0.3 0.5 1.8 -0.1 0.2 0.6 1.0 0.6 0.3 0.5 0.1 1.4 -1.1 0.5 0.3 -0.9 0.3 0.0 1.0 0.6
Illnesses of siblings: Diabetes 0.9 1.1 3.2 -0.3 1.2 -1.4 -0.2 -1.5 0.1 -1.4 -1.1 -0.6 -0.6 -1.2 -1.3 -1.6 0.1 -1.8 -0.5 -0.8
Smoking status: Previous 0.6 0.9 4.6 -2.1 0.9 -0.2 0.6 0.0 1.5 -0.7 0.6 0.4 -1.6 0.2 0.7 -0.2 1.1 1.4 0.9 0.5
Forced expiratory volume in 1-second (FEV1), predicted 2.3 4.8 9.4 -2.3 0.8 2.7 1.1 3.0 2.5 2.4 2.8 2.3 2.3 3.1 2.0 0.7 0.2 2.4 0.3 2.7
Whole body fat-free mass 0.5 2.6 11.2 -0.4 3.3 -0.9 -0.5 -0.2 3.3 -1.4 0.2 0.2 -0.4 -0.7 -1.9 -2.8 -2.3 -1.0 -0.7 0.1
Leg fat-free mass (right) 0.5 2.8 11.6 -0.6 3.4 -0.5 0.3 0.5 3.2 -1.2 0.8 0.5 -0.8 -0.2 -1.8 -3.2 -2.3 -1.1 -1.0 0.8
Arm fat percentage (left) 0.9 3.4 9.3 3.0 0.6 -1.8 -0.9 -1.6 -1.5 -2.0 -1.5 -1.1 -0.8 -1.9 -3.0 -0.7 -2.4 -1.3 -3.1 -1.5
Average weekly red wine intake 0.9 1.4 3.2 -1.2 1.6 1.2 0.7 1.5 1.2 1.2 1.4 1.0 1.8 1.6 0.5 -0.6 -0.9 0.8 0.3 1.3
Handedness (chirality/laterality): Left-handed 0.9 1.1 3.5 0.0 -0.4 -0.9 -1.9 -0.9 -1.4 -0.5 -1.4 -0.7 1.2 -0.8 -1.6 -0.2 -0.4 -1.6 -0.7 -1.2
Mood swings 1.3 2.4 9.0 -1.0 0.3 1.1 2.2 1.8 -0.4 0.8 1.3 1.0 0.2 1.0 2.1 -0.3 3.0 1.2 3.0 1.5
Loneliness, isolation 1.3 1.8 4.3 -0.3 -0.0 1.5 1.3 2.0 1.2 1.3 2.1 1.1 0.8 1.6 1.5 -0.8 0.8 -0.1 1.9 1.9
Long-standing illness, disability or infirmity 0.5 0.7 2.0 -0.6 1.4 0.9 0.9 1.1 -1.4 1.1 0.2 1.2 0.3 0.6 0.3 -0.9 -0.0 -0.4 0.5 0.4
Ever had bowel cancer screening 1.1 1.3 3.1 -0.7 1.8 1.3 1.8 1.4 -0.5 1.5 1.1 1.4 -0.1 1.2 1.5 0.4 0.3 -0.0 0.8 1.2
Diabetes diagnosed by doctor 0.5 0.8 2.1 0.2 1.5 -0.8 -0.0 -1.1 -0.6 -0.9 -1.0 0.4 -0.7 -0.8 -0.9 -1.3 1.4 -0.2 1.2 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 1.3 -0.6 -0.0 -0.1 0.2 0.2 1.0 -0.0 -0.0 0.3 1.2 0.0 0.0 0.5 0.5 0.1 -1.2 0.0
Friendships satisfaction 2.0 2.5 4.8 -0.7 1.7 1.9 2.1 2.2 0.7 1.9 2.2 1.5 1.5 2.1 0.9 -1.3 -1.0 -0.6 0.9 2.0
Qualifications: nursing, teaching 0.5 0.8 3.6 -0.5 0.7 1.0 1.9 1.1 -0.5 1.2 0.6 0.9 0.7 1.2 0.7 0.2 -1.0 0.2 -0.0 1.1
Commuting to job workplace: Walk 0.4 0.4 2.9 -0.4 0.3 0.3 0.8 0.3 0.5 0.2 0.3 1.7 -0.1 0.6 0.8 -0.1 -0.3 1.0 -0.1 0.4
Eye problems/disorders: Cataract 0.7 0.8 3.6 -1.5 0.6 -0.3 0.7 -0.4 1.6 -0.8 -0.0 1.9 -1.4 0.1 0.2 -0.9 0.1 0.7 0.3 0.1
Mouth/teeth dental problems: Mouth ulcers 1.9 3.0 6.1 -1.3 0.4 2.3 1.6 1.8 0.7 2.0 2.0 2.5 1.5 2.2 2.1 1.5 0.5 2.4 1.1 1.6
Medication for cholesterol 0.4 0.7 3.1 -0.9 0.7 0.5 1.0 0.6 1.8 0.2 0.8 1.1 -1.0 0.5 0.6 0.3 0.9 0.6 0.7 0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 3.5 -0.1 -1.9 -0.3 -0.3 -0.1 -1.3 -0.6 0.3 -0.3 -0.4 -0.1 0.2 -0.4 0.7 -0.5 0.4 0.1
Back pain experienced in last month 3.8 5.5 12.9 -3.0 2.1 3.4 1.7 3.6 0.8 3.5 2.8 2.2 1.8 3.0 2.1 -0.0 0.8 0.6 1.9 2.5
Mineral and other dietary supplements 1.2 1.6 4.5 1.5 1.0 -1.0 -1.0 -1.3 1.6 -0.5 -1.5 -1.8 0.6 -1.2 -1.3 0.8 -1.1 -1.1 -2.1 -1.4
Breast cancer (self-reported) 2.3 2.8 5.8 -1.5 0.2 2.2 1.9 2.3 0.6 2.3 1.7 2.4 1.3 2.2 2.0 0.9 -0.5 1.3 0.4 1.6
Asthma (self-reported) 0.6 1.1 5.0 -0.5 0.4 -1.1 -0.2 -1.2 0.8 -1.4 -0.6 -0.5 -0.9 -1.0 -1.1 -2.1 -0.4 -2.2 -0.1 -0.4
Osteoporosis (self-reported) 0.9 1.1 3.6 -1.3 1.9 0.9 1.5 0.9 0.6 0.8 1.0 1.1 0.7 1.1 0.9 -0.6 0.7 -1.0 0.5 1.1
Osteoarthritis (self-reported) 0.4 0.5 1.6 0.1 -1.2 0.7 0.2 1.0 -0.8 0.4 0.4 0.2 -0.7 0.7 0.3 -0.7 0.3 -0.7 1.3 0.4
Medication: Aspirin 0.3 0.4 0.9 0.3 0.6 -0.9 0.0 -0.7 -0.8 -0.9 -0.9 -0.1 -0.7 -0.6 -0.3 -0.2 0.0 -0.0 0.8 -0.7
Medication: Gliclazide 0.3 0.4 2.6 1.2 1.2 -0.1 0.3 -0.6 0.1 0.1 -0.7 0.1 0.3 -0.2 -0.1 0.1 1.6 0.0 -0.1 -0.4
Illnesses of father: None of the above (group 1) 0.8 1.0 5.3 -0.6 -0.1 1.0 0.3 1.1 -0.6 1.2 0.6 -0.0 2.3 1.0 1.4 2.0 -0.2 0.8 0.1 0.2
Smoking status: Current 0.5 0.8 4.0 0.8 -0.0 -0.9 -0.4 -0.8 -0.5 -1.0 -0.3 -0.2 -1.4 -0.5 -1.7 0.4 -0.5 -0.6 -2.0 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 3.8 0.7 -1.9 -0.1 -1.4 0.0 -0.8 0.1 -0.4 -0.5 -0.1 -0.3 -0.2 -1.5 -0.8 -1.0 0.9 -0.2
Whole body water mass 0.5 2.6 10.9 -0.4 3.3 -0.9 -0.4 -0.1 3.3 -1.5 0.2 0.3 -0.5 -0.7 -1.9 -2.8 -2.3 -0.9 -0.7 0.1
Leg predicted mass (right) 0.5 2.7 11.6 -0.5 3.4 -0.5 0.4 0.5 3.1 -1.2 0.8 0.5 -0.8 -0.2 -1.7 -3.2 -2.3 -1.1 -0.9 0.8
Arm fat mass (left) 0.8 3.1 8.7 2.4 1.4 -1.9 -0.9 -1.4 -0.1 -2.3 -1.2 -0.9 -1.1 -1.9 -3.0 -1.5 -2.5 -1.3 -2.6 -1.2
Number of self-reported non-cancer illnesses 0.4 0.7 4.6 -0.8 0.8 -0.3 0.7 -0.0 -0.9 -0.6 0.4 -0.1 -0.1 0.2 -0.5 -1.8 -1.1 -2.1 0.1 0.4
Average weekly champagne plus white wine intake 1.2 1.7 5.2 -0.6 -0.1 1.5 1.2 1.5 -1.0 1.9 1.1 1.1 0.9 1.5 2.3 0.5 0.8 1.2 1.8 1.2
Miserableness 1.5 2.6 6.7 -1.6 -0.3 1.7 2.4 2.4 -1.1 1.0 2.6 1.5 -1.3 1.6 0.6 -1.5 0.7 0.0 1.7 2.4
Guilty feelings 2.5 3.8 6.0 -1.6 -0.1 2.2 2.0 2.3 2.5 1.9 2.3 2.2 0.8 2.1 2.2 1.5 1.9 1.9 2.0 2.2
Wears glasses or contact lenses 2.8 3.2 6.1 1.4 -1.9 -2.2 -2.1 -2.4 1.0 -2.3 -2.1 -1.5 -0.8 -2.5 -2.0 -1.2 0.9 -1.5 -0.4 -2.1
Ever taken oral contraceptive pill 0.4 0.5 3.5 -0.3 -1.0 -0.3 -0.3 -0.2 -0.9 -0.4 0.2 0.5 -0.8 -0.1 0.0 -1.1 1.9 -0.1 0.2 0.2
Hearing aid user 4.9 5.5 12.5 3.5 -1.3 -2.3 -2.6 -2.2 -2.6 -1.6 -2.7 -1.6 -1.3 -2.8 -3.1 -1.9 -1.3 -2.9 -1.6 -2.7
Mother’s age at death 1.1 1.4 4.8 1.2 -0.2 -1.4 -1.2 -1.4 -0.8 -1.1 -1.2 -0.8 -2.2 -1.3 -1.3 -1.3 -0.3 -0.3 0.0 -1.6
Financial situation satisfaction 0.3 0.4 1.8 -0.5 0.4 1.0 0.1 0.8 0.1 1.3 0.7 0.2 0.1 0.8 0.1 0.3 -0.9 -0.2 -0.8 0.7
Tinnitus: Yes, now most or all of the time 1.2 1.4 15.2 0.8 0.9 0.2 0.5 0.3 -0.1 0.3 0.2 0.8 -0.2 -0.2 -1.0 1.1 -3.9 1.2 -1.2 -0.5
Commuting to job workplace: Public transport 0.7 0.9 2.1 1.5 -0.0 -1.3 -1.3 -1.1 -0.2 -1.0 -1.4 -0.1 0.4 -0.8 -0.9 -0.6 0.8 -0.6 -0.9 -1.3
Eye problems/disorders: Glaucoma 1.0 1.1 6.0 1.5 -2.4 -0.0 -1.1 -0.4 -0.3 0.5 -0.6 -0.1 -0.6 -0.5 -0.9 -1.9 0.2 -1.7 0.7 -0.7
Medication: Blood pressure 0.3 0.5 3.1 0.2 0.8 -0.5 -0.4 -0.8 -1.8 -0.5 -0.4 -0.9 0.8 -0.4 -0.3 -0.6 0.2 -0.9 0.3 -0.2
Pain type(s) experienced in last month: Hip pain 1.0 1.3 3.2 -0.8 -0.2 1.7 0.3 1.5 -0.2 1.8 1.6 1.2 0.7 1.4 0.6 -0.6 -0.1 -0.3 1.8 1.6
Supplements: Fish oil (including cod liver oil) 0.7 0.9 2.9 -0.7 -1.7 0.5 0.2 0.9 -0.9 -0.1 1.1 0.9 -0.8 0.6 0.6 -1.1 0.7 0.5 1.7 1.1
High cholesterol (Self-reported) 0.4 0.8 3.1 -0.3 0.2 0.1 1.1 0.2 -1.0 -0.2 0.9 0.6 -1.2 0.7 -0.3 -1.8 0.7 -1.5 0.6 1.1
Medication: Bendroflumethiazide 1.9 2.9 6.5 -2.5 2.0 1.9 1.3 1.6 0.7 1.9 1.9 1.7 0.4 2.2 2.2 0.5 1.2 1.6 1.9 1.8
Medication: Paracetamol 3.2 4.9 10.5 -2.3 2.4 2.2 2.3 2.5 1.2 2.5 2.3 2.4 1.9 2.4 3.2 0.6 2.0 0.7 2.8 2.3
Medication: Lisinopril 0.5 0.7 4.8 0.4 0.9 -0.7 -0.1 -0.8 -0.1 -0.5 -0.8 0.1 -0.1 -0.6 0.8 0.8 2.2 -0.4 1.2 -0.4
Medication: Atorvastatin 0.6 0.8 2.7 -1.0 0.9 -0.1 -0.0 -0.5 -1.1 -0.2 0.1 -0.4 -0.2 -0.0 -1.2 -1.4 -1.6 -1.4 -1.2 0.4
Illnesses of father: High blood pressure 0.6 0.7 1.7 -0.3 0.1 -0.9 -0.7 -1.0 0.6 -1.1 -0.3 -1.0 -1.2 -1.0 -1.3 -1.1 -0.5 -0.6 -1.1 -0.2
Alcohol drinker status: Never 1.3 1.5 2.7 1.5 0.2 -1.3 -0.8 -1.6 0.9 -1.0 -1.2 -1.6 -0.0 -1.4 -1.2 1.1 -1.6 -1.2 -1.5 -1.4
Ever smoked 0.6 1.1 4.8 -1.7 0.0 0.7 0.4 0.8 0.1 0.1 1.3 0.5 -1.2 1.2 1.0 0.5 2.2 1.4 0.4 1.3
Basal metabolic rate 0.5 2.6 10.9 -0.0 3.3 -1.0 -0.4 -0.2 3.0 -1.6 0.1 0.0 -0.5 -0.8 -2.1 -2.7 -2.3 -0.9 -0.9 -0.0
Leg fat percentage (left) 1.5 5.3 13.8 3.7 -0.4 -2.6 -2.0 -2.5 -0.7 -2.6 -2.1 -2.4 -1.5 -2.8 -3.4 -0.1 -1.9 -1.4 -3.1 -2.4
Arm fat-free mass (left) 0.5 2.4 10.0 -0.1 3.0 -1.2 -0.5 -0.5 3.2 -1.8 0.0 -0.1 -0.9 -1.0 -1.9 -2.7 -1.7 -1.1 -0.5 -0.1
Number of operations (self-reported) 0.4 0.6 2.6 0.1 0.2 -0.4 1.6 0.0 -1.3 -0.9 0.6 0.6 -0.9 0.0 -0.0 -1.0 0.2 -0.5 1.2 0.3
Average weekly beer plus cider intake 1.6 2.3 11.2 3.4 -2.5 -1.3 -1.0 -1.4 1.7 -1.4 -1.1 -0.7 -0.9 -1.7 -1.5 0.8 1.0 -0.6 -0.8 -1.4
Irritability 0.9 1.5 3.8 -0.8 -0.1 1.4 1.7 1.9 -0.7 0.9 1.8 0.6 0.7 0.9 0.5 -1.6 1.2 -0.0 1.6 1.8
Risk taking 0.6 0.8 2.0 0.7 -0.8 -1.2 -0.4 -0.9 -0.4 -1.2 -0.6 -1.4 -0.1 -1.0 -1.4 -0.9 -0.9 -1.1 -0.6 -0.5
Ever had prostate specific antigen (PSA) test 1.0 1.2 5.8 -1.3 0.4 -0.1 0.2 -0.1 -2.2 -0.5 0.3 0.6 -1.4 -0.3 -0.8 -1.9 -2.4 0.0 0.6 -0.1
Fractured/broken bones in last 5 years 4.0 5.1 10.5 -2.4 2.1 2.9 3.0 2.5 -0.2 2.2 3.2 3.1 0.5 3.1 1.7 -0.1 0.5 0.8 2.0 3.2
Age started oral contraceptive pill 0.6 0.7 3.9 -2.0 -0.7 0.3 0.1 0.6 -0.2 -0.0 0.5 1.3 -0.4 0.8 1.2 -0.2 1.2 1.1 0.6 0.6
Diastolic blood pressure, automated reading 1.0 3.1 6.1 2.3 0.4 -2.2 -1.7 -2.3 0.1 -2.1 -2.4 -2.1 -0.8 -2.4 -2.1 0.2 -0.5 -0.3 -1.4 -2.5
Ever depressed for a whole week 0.8 1.0 3.1 -0.4 -0.6 1.5 0.3 1.8 0.8 1.2 1.6 0.8 0.6 1.6 0.8 -0.5 -0.0 0.6 0.6 1.4
Unable to work because of sickness or disability 0.4 0.5 1.9 -0.2 -0.3 0.5 0.4 0.2 -0.2 0.5 0.4 0.6 0.3 0.7 1.4 1.0 1.1 0.2 1.2 0.3
Commuting to job workplace: Cycle 0.5 0.6 2.4 0.6 -1.1 -1.0 -0.2 -0.3 -0.0 -1.1 -0.4 -0.2 0.0 -0.8 -0.7 -0.4 1.6 -0.4 1.1 -0.6
Myopia 0.8 1.1 4.8 -1.7 2.2 1.1 1.1 1.0 1.1 1.0 1.0 -0.0 1.1 0.9 0.6 0.1 0.3 -0.8 -0.5 1.0
Vascular/heart problems diagnosed by doctor 0.8 2.2 4.9 -0.3 -0.9 2.1 0.4 2.2 2.0 2.2 1.7 1.6 1.4 1.9 1.3 0.7 0.6 0.9 0.7 1.7
Cholesterol lowering medication 0.5 0.8 3.2 -1.1 0.5 0.3 1.0 0.8 -1.3 0.4 0.7 0.6 -0.3 0.9 0.5 -1.8 -0.1 -1.3 -0.4 1.0
Medication: Omeprazole (e.g. Zanprol) 1.9 2.3 5.2 -1.6 0.5 2.1 1.6 1.9 -0.7 1.9 1.6 2.3 -0.3 1.9 1.1 -1.0 -0.0 0.1 2.2 1.6
Pain experienced in last month 3.7 6.2 12.0 2.5 -2.8 -3.4 -3.1 -3.5 -2.0 -3.1 -3.0 -2.6 -2.0 -3.0 -1.7 -1.0 -0.7 0.2 -1.5 -3.1
Supplements: Calcium 0.5 0.5 4.2 -0.6 1.0 -0.0 0.3 -0.3 -2.0 0.3 -0.4 0.2 0.4 -0.0 0.6 1.5 -0.0 0.7 0.2 -0.4
Basal cell carcinoma (self-reported) 0.6 0.7 5.6 -0.6 -1.0 -0.3 0.6 0.2 -0.4 -0.8 0.3 -0.3 -2.4 -0.2 -0.2 0.2 -1.1 1.4 -1.0 0.0
Heart attack/myocardial infarction (self-reported) 1.9 2.4 5.0 -1.5 1.8 1.9 1.3 2.2 1.8 1.9 1.5 1.1 -0.2 1.6 1.2 -1.4 1.4 -0.1 1.9 1.9
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 4.6 0.6 0.6 -0.5 -0.9 -0.6 2.1 -0.4 -1.0 -0.9 -0.6 -0.9 -0.6 -1.0 -2.1 -0.5 -1.0 -0.4
Heart disease (siblings) 0.9 1.1 6.3 -0.8 -1.5 1.1 -0.2 0.8 -0.8 1.3 0.6 1.0 1.5 0.7 0.1 0.3 -2.5 -0.5 0.8 0.4
Alcohol drinker status: Previous 0.7 0.8 3.1 0.9 -0.9 0.1 0.1 0.1 0.9 -0.4 0.7 -0.4 -1.2 0.3 -0.4 -1.7 1.8 -1.0 1.1 1.0
Pack years of smoking 0.6 0.9 2.7 0.5 -0.3 0.8 1.6 1.3 0.7 0.3 1.6 0.1 -0.8 0.9 -0.1 -0.8 1.0 -0.8 0.6 1.7
Impedance of whole body 0.7 3.6 8.7 -1.3 -1.3 2.5 1.1 1.9 -0.4 2.8 1.7 1.8 1.5 2.3 3.0 1.5 2.2 1.4 2.2 1.7
Leg fat mass (left) 0.8 3.0 8.2 2.3 0.9 -2.1 -1.0 -1.6 0.7 -2.5 -1.0 -1.2 -1.4 -2.0 -2.9 -1.0 -2.2 -1.0 -2.4 -1.2
Arm predicted mass (left) 0.5 2.7 9.7 0.1 2.8 -1.4 -0.8 -0.8 3.1 -1.9 -0.3 -0.2 -1.0 -1.3 -2.2 -2.9 -1.9 -1.2 -0.6 -0.4