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chr4:305,291-2,058,475

Best TWAS P=1.91e-13 · Best GWAS P=2.89e-08 conditioned to 0.0612

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	UVSSA	0.30	0.14	enet	44	0.28	1.4e-22	-4.1	5.6	1.7e-08	0.40	0.58	0.37	FALSE
2	GTEx	Artery Aorta	UVSSA	0.33	0.06	enet	30	0.28	7.2e-16	1.9	5.6	2.2e-08	0.55	0.01	0.99	FALSE
3	GTEx	Artery Aorta	CRIPAK	0.31	0.20	enet	34	0.30	2.8e-17	2.6	5.3	1.2e-07	0.44	0.82	0.10	FALSE
4	GTEx	Artery Tibial	MAEA	0.16	0.11	enet	19	0.11	7.9e-09	-4.0	-5.2	1.6e-07	-0.26	0.64	0.30	FALSE
5	GTEx	Artery Tibial	UVSSA	0.27	0.01	enet	40	0.14	1.9e-11	-3.3	5.6	2.3e-08	0.38	0.42	0.49	FALSE
6	GTEx	Artery Tibial	CRIPAK	0.42	0.09	enet	50	0.34	1.3e-27	-4.1	5.4	7.1e-08	0.37	0.60	0.34	FALSE
7	GTEx	Brain Cerebellar Hemisphere	UVSSA	0.26	-0.01	enet	23	0.10	1.8e-03	4.0	6.8	1.3e-11	0.66	0.03	0.63	FALSE
8	GTEx	Brain Cerebellum	CRIPAK	0.37	0.09	enet	24	0.31	8.8e-10	2.5	5.3	1.1e-07	0.46	0.13	0.66	FALSE
9	GTEx	Brain Putamen basal ganglia	UVSSA	0.23	-0.01	lasso	7	0.00	3.2e-01	-4.5	6.8	1.5e-11	0.65	0.02	0.46	FALSE
10	GTEx	Brain Putamen basal ganglia	CRIPAK	0.30	0.00	enet	25	0.10	1.9e-03	1.7	6.0	1.8e-09	0.49	0.02	0.62	FALSE
11	GTEx	Breast Mammary Tissue	UVSSA	0.23	0.07	enet	30	0.24	1.5e-12	4.0	5.9	4.5e-09	0.40	0.55	0.32	FALSE
12	GTEx	Breast Mammary Tissue (Female)	UVSSA	0.21	0.02	enet	24	0.05	1.3e-02	1.4	5.1	2.7e-07	0.49	0.04	0.50	FALSE
13	GTEx	Colon Transverse	UVSSA	0.29	0.17	enet	28	0.23	2.1e-11	4.0	5.6	2.2e-08	0.39	0.58	0.31	FALSE
14	GTEx	Esophagus Mucosa	UVSSA	0.33	0.23	enet	21	0.28	4.9e-19	4.0	5.7	1.2e-08	0.50	0.72	0.21	FALSE
15	GTEx	Heart Atrial Appendage	UVSSA	0.35	0.17	enet	26	0.34	5.5e-16	2.6	5.6	2.2e-08	0.30	0.73	0.07	FALSE
16	GTEx	Lung	UVSSA	0.42	0.12	lasso	15	0.26	3.2e-20	4.0	5.9	4.3e-09	0.46	0.65	0.28	FALSE
17	GTEx	Muscle Skeletal	FGFRL1	0.14	0.08	lasso	4	0.06	3.7e-06	5.5	-5.3	1.1e-07	-0.98	0.00	1.00	FALSE
18	GTEx	Muscle Skeletal	CRIPAK	0.25	0.11	enet	32	0.18	7.6e-18	2.6	5.3	1.0e-07	0.52	0.79	0.13	FALSE
19	GTEx	Nerve Tibial	UVSSA	0.32	0.14	enet	21	0.30	3.7e-21	4.0	5.8	8.2e-09	0.40	0.71	0.22	FALSE
20	GTEx	Pancreas	UVSSA	0.15	0.13	lasso	8	0.09	9.3e-05	4.0	5.7	1.3e-08	0.36	0.14	0.57	FALSE
21	GTEx	Pituitary	UVSSA	0.43	0.07	lasso	7	0.24	9.3e-07	4.0	5.6	1.8e-08	0.31	0.42	0.29	FALSE
22	GTEx	Pituitary	CRIPAK	0.39	0.06	enet	29	0.13	4.6e-04	-4.1	5.6	1.8e-08	0.43	0.10	0.53	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	CRIPAK	0.39	0.14	lasso	13	0.34	1.5e-19	2.6	5.3	8.7e-08	0.42	0.11	0.88	FALSE
24	GTEx	Skin Sun Exposed Lower leg	UVSSA	0.41	0.30	lasso	11	0.38	1.3e-33	4.0	5.4	5.3e-08	0.33	0.70	0.23	FALSE
25	GTEx	Skin Sun Exposed Lower leg	CRIPAK	0.36	0.09	enet	40	0.35	8.7e-30	2.3	5.5	3.7e-08	0.46	0.89	0.02	FALSE
26	GTEx	Thyroid	CRIPAK	0.51	0.14	enet	44	0.34	6.1e-27	-4.5	5.5	4.7e-08	0.43	0.34	0.63	FALSE
27	NTR	Blood	KIAA1530	0.19	0.04	blup	345	0.10	9.1e-32	1.9	5.4	5.7e-08	0.48	0.84	0.08	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	UVSSA	0.31	0.05	blup	350	0.23	7.1e-29	-4.4	7.4	1.9e-13	0.54	0.03	0.97	TRUE