TWAS hub - FGFRL1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0350	0.0210	4.2e-02	0.001	0.006	0.010	0.01	0.007	2.1e-01	6.2e-02	1.7e-02	0.02	4.5e-02
2	GTEx	Artery Tibial	0.0806	0.0392	2.6e-03	-0.002	NA	0.052	NA	0.018	5.4e-01	NA	6.5e-05	NA	1.3e-02
3	GTEx	Brain Cerebellum	0.3190	0.0970	1.2e-03	0.008	NA	0.111	NA	0.093	1.8e-01	NA	3.8e-04	NA	1.0e-03
4	GTEx	Cells Transformed fibroblasts	0.1140	0.0370	5.9e-06	0.012	NA	0.046	NA	0.036	3.7e-02	NA	2.3e-04	NA	9.3e-04
5	GTEx	Muscle Skeletal	0.1365	0.0684	4.1e-03	0.084	NA	0.043	NA	0.056	1.3e-08	NA	4.2e-05	NA	3.7e-06
6	GTEx	Pancreas	0.2270	0.0800	4.7e-04	0.070	NA	0.102	NA	0.106	7.0e-04	NA	4.5e-05	NA	3.1e-05
7	GTEx	Skin Not Sun Exposed Suprapubic	0.1220	0.0500	6.0e-03	-0.002	NA	-0.001	NA	-0.005	4.0e-01	NA	3.9e-01	NA	8.6e-01
8	GTEx	Stomach	0.1160	0.0510	6.5e-03	0.014	NA	-0.004	NA	0.014	6.7e-02	NA	5.4e-01	NA	6.7e-02
9	GTEx	Thyroid	0.3920	0.0620	5.4e-10	0.051	NA	0.140	NA	0.092	9.2e-05	NA	6.9e-11	NA	1.5e-07
10	TCGA	Thyroid Carcinoma	0.3360	0.0900	7.6e-10	0.049	0.144	0.174	NA	0.082	1.6e-05	6.6e-14	1.2e-16	NA	2.0e-08

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	8	9	10
Heel T-Score	38.3	304.5	967.2	-22.3	24.6	17.9	8.9	8.1	-7.4	0.8	31.1	21.3
Heel bone mineral density (BMD) T-score, automated (left)	22.7	51.5	171.6	-8.8	9.1	8.1	3.7	3.3	-1.6	0.9	13.1	9.4
Heel bone mineral density (BMD) T-score, automated (right)	21.1	48.5	158.8	-9.3	9.2	7.2	3.0	3.1	-1.6	0.6	12.6	9.1
Fractured/broken bones in last 5 years	8.7	11.2	26.9	4.6	-5.2	-2.0	-2.6	-0.5	1.9	-0.5	-5.2	-4.8
Primary Biliary Cirrhosis	4.7	6.6	24.4	0.3	2.1	2.1	4.9	-0.9	-1.1	3.8	2.7	3.1
Waist Hip Ratio (WHR)	4.6	20.5	58.9	-3.0	-3.0	-5.0	-4.8	-0.2	-0.8	-7.7	-6.2	-6.4
Neck or shoulder pain in last month	4.5	6.4	20.7	-0.9	1.4	3.1	2.7	0.9	-0.0	3.2	3.5	4.5
Heart attack	4.4	5.6	11.8	0.6	-3.4	-2.1	-3.4	0.5	1.1	-2.8	-3.4	-2.6
Leg pain on walking	4.4	5.5	12.5	-2.5	1.7	3.2	2.6	-1.2	-1.5	1.8	3.5	3.2
Heart attack/myocardial infarction (self-reported)	4.0	5.2	11.4	0.5	-3.2	-2.1	-3.2	0.1	0.8	-2.9	-3.4	-2.5
Osteoporosis (self-reported)	3.9	4.8	14.9	2.1	-2.5	-2.8	-1.3	-0.3	1.3	2.0	-3.9	-2.8
Pulse wave reflection index	3.3	4.0	13.4	0.7	-2.7	-1.1	-1.3	-1.1	1.9	0.1	-3.7	-3.4
Chronotype (morning person)	2.8	6.5	28.2	-1.8	2.4	-0.6	2.2	-5.3	-4.4	-0.1	0.1	1.9
Back pain experienced in last month	2.5	3.7	9.7	-2.5	1.9	2.1	1.7	-0.6	-0.2	1.6	2.6	3.1
Deep venous thrombosis (DVT) (self-reported)	2.3	2.9	9.5	1.1	1.3	3.1	2.2	2.3	0.7	0.9	2.1	0.9
Medication: Ramipril	2.2	2.8	8.4	0.1	-1.8	-1.6	-2.9	-0.4	1.1	-2.2	-1.4	-2.5
Medication: Allopurinol	2.2	2.9	7.9	-0.9	1.3	1.4	2.6	-1.5	-2.8	0.3	1.2	2.6
Average weekly spirits intake	2.1	2.7	6.0	-2.5	2.1	2.0	1.7	-0.4	-0.8	0.7	2.4	1.6
Relative age voice broke	2.1	3.2	7.9	-0.4	-2.1	-1.5	-2.5	1.3	2.8	-0.9	-1.6	-2.5
Pain experienced in last month	2.1	3.5	10.0	1.5	-0.3	-2.8	-2.2	-0.3	-1.0	-2.7	-1.4	-3.2
Mouth/teeth dental problems: Dentures	2.0	3.3	12.6	1.3	-2.6	-1.5	-2.8	1.4	0.7	-3.5	-0.0	-0.3
Trunk predicted mass	2.0	11.2	52.7	2.1	0.8	2.9	2.0	7.3	2.4	0.9	5.2	2.8
Blood clot in the leg (DVT)	2.0	2.6	7.5	1.0	0.9	2.7	2.0	2.7	1.1	0.8	1.8	0.7
Gout (self-reported)	2.0	2.7	12.5	-0.3	1.5	0.7	2.6	-1.6	-3.5	-0.4	0.6	1.2
Medication: Seretide 50 evohaler	2.0	2.3	6.2	2.0	1.3	0.7	1.9	0.9	-0.9	2.5	1.6	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	7.5	-0.6	-2.7	-0.4	-1.9	0.7	2.2	0.4	-1.6	-1.1
Wears glasses or contact lenses	2.0	2.3	6.2	1.5	0.3	2.0	1.6	0.4	0.0	1.6	2.3	2.5
Other serious medical condition/disability diagnosed by doctor	1.9	2.5	6.9	-1.3	-0.3	1.3	2.6	-0.0	-0.6	2.5	1.2	2.6
Trunk fat-free mass	1.9	11.2	52.9	2.1	0.8	2.9	2.0	7.3	2.4	0.9	5.2	2.8
Eye problems/disorders: Glaucoma	1.9	2.3	11.1	-0.3	0.5	0.5	3.3	-1.8	-0.7	2.4	-1.1	0.2
Prostate Cancer	1.8	2.5	7.7	1.2	-2.6	-2.4	-1.5	-0.2	0.5	0.6	-2.8	-0.4
Medication for hormone replacement therapy	1.8	2.0	9.5	1.4	-0.8	-0.8	0.2	-0.0	-0.7	-1.3	-3.1	-2.1
Forced vital capacity (FVC)	1.8	7.0	19.1	-1.9	3.0	2.4	2.4	4.4	-0.5	0.9	4.4	2.5
Had major operations	1.8	2.1	6.4	-0.7	0.6	2.3	1.9	1.0	0.6	0.8	2.5	1.7
Whole body water mass	1.8	10.1	49.8	2.3	0.5	2.7	1.7	7.1	2.2	0.2	4.8	2.7
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.1	-2.0	1.8	1.8	1.1	-0.2	-1.0	-0.1	2.1	2.3
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	15.7	0.6	0.1	1.5	0.5	4.0	1.5	1.0	2.9	1.9
Whole body fat-free mass	1.7	9.9	49.6	2.2	0.5	2.7	1.6	7.0	2.2	0.2	4.8	2.6
Eye problems/disorders: Cataract	1.7	1.9	6.9	0.8	1.1	1.9	0.5	2.2	-0.9	0.1	2.6	1.0
Mineral and other dietary supplements	1.7	2.3	8.7	-0.4	0.6	-3.0	-0.8	-1.0	-0.3	-1.2	-1.7	-2.7
Medication: Atorvastatin	1.7	2.1	7.2	0.8	0.4	-2.2	-2.3	-0.7	-1.5	-2.7	-0.4	-0.6
Number of operations (self-reported)	1.7	2.6	5.0	2.2	0.6	2.1	2.1	1.5	0.9	1.9	1.8	1.2
Ever had prostate specific antigen (PSA) test	1.7	2.0	6.1	-0.6	-0.2	2.5	2.0	-1.3	0.3	2.1	1.4	1.2
Ever depressed for a whole week	1.7	2.1	7.6	-0.7	1.3	1.6	0.4	2.2	0.4	1.0	2.8	1.5
Maternal smoking around birth	1.6	2.3	6.9	-0.0	-2.6	0.4	-1.5	1.4	2.1	0.2	-2.0	-1.8
Pain all over the body in last month	1.6	1.7	5.6	0.4	-2.0	0.3	-0.2	-0.6	2.4	1.2	-2.1	-0.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	6.0	1.0	0.6	0.8	0.8	1.9	0.3	1.5	2.5	2.4
Glaucoma (self-reported)	1.6	1.9	9.6	0.1	0.7	0.8	3.1	-1.6	-0.5	2.1	-0.6	-0.2
Medication: Amlodipine	1.6	2.2	7.2	1.4	-0.5	-0.5	-2.6	2.7	0.5	-2.2	0.7	0.0
Arm fat-free mass (right)	1.6	8.3	42.2	2.2	0.5	1.8	1.3	6.5	1.7	-0.0	4.5	2.8
Arm predicted mass (right)	1.6	8.1	40.7	2.0	0.5	1.9	1.2	6.4	1.9	0.1	4.4	2.8
Illnesses of siblings: Diabetes	1.6	2.0	11.6	0.0	-1.8	-1.1	0.6	-1.0	-0.7	0.1	-3.4	-1.5
Basal metabolic rate	1.6	8.8	45.7	2.1	0.6	2.6	1.3	6.8	1.8	-0.5	4.5	2.4
Arm fat-free mass (left)	1.6	8.3	42.4	2.2	0.7	2.2	1.2	6.5	1.9	-0.1	4.2	2.8
Cholesterol lowering medication	1.6	2.3	11.1	0.1	-0.7	-1.2	-3.3	1.5	0.5	-2.3	-0.7	-1.5
Arm predicted mass (left)	1.6	7.9	39.7	1.9	0.6	2.3	1.4	6.3	1.8	0.1	4.1	2.8
Blood White Count	1.5	11.2	30.4	-2.5	2.1	2.2	3.4	-4.5	-4.8	1.7	2.8	5.5
Eye problems/disorders: Diabetes related eye disease	1.5	1.7	4.2	1.4	-1.8	-1.8	-2.0	-0.0	0.1	-0.9	-1.6	-1.0
Stomach or abdominal pain in last month	1.5	1.9	6.4	-0.2	2.0	-0.3	0.3	-0.8	-1.4	1.3	1.9	2.5
Pulse rate, automated reading	1.5	4.7	13.6	-1.4	3.7	1.1	3.4	-1.7	-0.2	2.7	0.3	2.9
Age at last live birth	1.5	2.2	7.1	0.5	-1.1	-2.7	-1.7	-0.9	-0.5	-2.2	-1.7	-1.2
Knee pain experienced in last month	1.5	2.3	5.4	-0.4	0.9	2.2	1.8	1.0	-0.5	1.9	2.0	2.3
Smoking status: Previous	1.5	2.3	7.2	0.3	-2.7	-1.7	-2.1	-0.6	1.6	-1.9	-0.9	-0.6
Ever had bowel cancer screening	1.5	1.7	4.6	2.1	-1.2	1.3	1.5	0.7	1.2	2.1	-0.4	0.8
High cholesterol (Self-reported)	1.5	2.7	8.6	-0.7	-1.1	-1.6	-2.8	-1.6	-0.3	-2.9	-1.4	-1.3
Mean Putamen Volume	1.4	1.6	3.9	-1.5	-2.0	0.3	-0.8	1.6	1.6	0.9	-0.2	-1.8
Neuroticism (2016)	1.4	2.1	8.3	1.5	-2.9	0.2	-1.4	1.2	2.2	-0.3	-1.1	-0.9
Diabetes (mother)	1.4	1.8	5.7	-0.2	0.0	-1.8	-1.1	-1.5	-1.1	-2.0	-2.4	0.1
Leg fat-free mass (left)	1.4	7.3	37.1	1.9	0.2	2.7	1.1	6.1	1.8	-0.5	4.0	2.0
Hand grip strength (right)	1.4	3.7	27.2	1.6	0.4	0.3	-0.5	5.2	0.6	-0.8	2.3	0.5
Medication: Cholesterol lowering	1.4	2.2	9.0	-0.3	-0.7	-1.0	-0.0	-3.0	-2.3	-2.0	-1.6	0.2
Supplements: Fish oil (including cod liver oil)	1.4	1.8	8.8	0.5	-0.3	3.0	1.3	0.6	0.3	0.7	1.2	2.3
Medication: Lisinopril	1.4	1.8	6.9	0.6	1.2	1.2	2.6	-0.8	-1.0	1.9	-0.2	1.3
Myopia	1.4	2.0	6.4	1.3	-2.5	-0.1	-1.1	1.7	1.9	-1.5	-1.1	-0.8
Bipolar Disorder or Schizophrenia	1.3	3.1	13.3	-2.2	1.2	1.9	3.6	-1.3	-1.2	1.3	1.7	0.0
Smoking Status	1.3	3.1	11.9	1.4	-3.1	-0.0	-1.4	1.2	3.4	-1.2	-1.1	-1.3
Relative age of first facial hair	1.3	2.8	6.9	0.6	-0.7	-2.2	-1.9	2.1	0.9	-2.6	-1.2	-2.2
Leg predicted mass (left)	1.3	7.1	36.6	2.0	0.3	2.6	1.1	6.0	1.7	-0.7	4.0	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.1	6.4	0.7	-2.5	-1.0	-1.5	0.5	1.4	-1.6	-1.9	-1.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	13.9	-1.1	2.9	0.5	1.3	3.7	-1.6	-0.4	3.4	1.7
Standing height	1.3	12.7	89.5	1.1	0.4	2.4	0.7	9.5	2.7	1.3	4.5	0.5
Eye problems/disorders: None of the above	1.3	1.6	5.2	-0.2	-0.3	-1.8	-1.9	-0.1	0.1	-2.3	-1.1	-1.4
Leg fat-free mass (right)	1.3	7.2	36.8	1.9	0.1	2.5	1.3	6.1	1.7	-0.7	3.9	2.1
Long-standing illness, disability or infirmity	1.3	1.9	4.9	-1.6	0.5	1.5	2.2	-1.4	-0.7	1.6	0.8	1.9
Medication for cholesterol	1.3	1.9	6.6	-0.5	0.0	0.8	1.2	-0.4	0.6	2.6	2.2	2.2
Leg predicted mass (right)	1.3	7.1	36.8	1.9	0.1	2.5	1.3	6.1	1.8	-0.6	3.8	2.1
Commuting to job workplace: Cycle	1.3	1.6	7.2	-0.1	1.4	-0.8	-1.6	1.2	-1.1	-2.7	0.9	0.0
Supplements: Calcium	1.3	1.4	3.7	1.6	-1.0	-1.4	-1.9	0.6	0.2	1.3	-1.4	-0.8
Coronary Artery Disease (CAD)	1.2	1.4	5.1	0.1	0.6	-2.2	0.0	0.0	-2.3	-1.3	-1.6	0.0
Ever used hormone-replacement therapy (HRT)	1.2	1.6	7.5	2.7	-0.5	-1.1	-0.6	2.4	-0.0	0.1	-0.5	-0.5
Ever had hysterectomy (womb removed)	1.2	1.3	5.6	2.2	-0.4	0.6	0.7	0.5	0.8	2.4	-0.6	0.7
Systolic blood pressure, automated reading	1.2	3.5	12.8	3.6	0.5	-1.6	-1.4	0.9	-2.1	-3.2	0.2	-1.3
Supplements: Zinc	1.2	1.3	2.8	-1.4	1.1	-0.7	-1.0	-1.4	-1.0	0.0	1.6	1.7
Supplements: Glucosamine	1.2	1.5	4.8	0.3	0.9	1.9	0.3	1.5	-0.0	0.1	2.2	1.9
Birth weight of first child	1.2	2.2	11.6	-1.2	-0.4	-0.4	-2.2	1.5	0.1	-3.4	-0.2	-1.1
Age at first live birth	1.2	2.2	9.0	0.3	-0.3	-3.0	-2.2	-0.8	-1.2	-2.2	-0.4	-0.9
Shortness of breath walking on level ground	1.2	1.4	3.8	-1.2	1.1	2.0	1.8	-0.7	-1.5	1.1	0.7	0.1
Overall health rating	1.2	2.6	10.8	-0.7	-0.5	2.1	2.1	-0.1	0.3	1.9	1.4	3.3
Mood swings	1.2	2.1	9.5	3.1	-1.4	0.0	-1.5	2.4	1.3	-0.3	-0.5	-0.2
Reaction Time	1.1	2.1	7.3	0.3	0.2	2.7	1.2	0.6	1.2	2.5	1.8	1.0
Height	1.1	20.9	144.0	2.1	0.5	3.3	1.3	12.0	4.0	2.4	5.0	1.1
Hand grip strength (left)	1.1	2.9	22.7	0.5	-0.1	0.7	-0.3	4.8	1.0	-0.2	2.0	0.5
Medication: Metformin	1.1	1.5	5.7	0.7	-0.0	-1.3	0.1	-1.8	-2.4	-0.6	-1.7	0.9
Ever unenthusiastic/disinterested for a whole week	1.1	1.3	8.3	-0.5	-0.3	0.9	-0.3	2.9	1.3	0.1	1.3	-0.3
Diabetes (self-reported)	1.1	1.7	7.5	0.1	-1.4	-1.3	-0.6	-1.7	-1.0	-1.1	-2.7	-0.2
Alcohol intake versus 10 years previously	1.1	1.6	4.8	1.2	0.8	-2.2	0.1	0.0	-1.9	-2.0	-1.2	0.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	9.0	-0.3	-0.2	1.0	-0.5	2.5	3.0	1.1	0.5	-0.4
Mouth/teeth dental problems: Loose teeth	1.1	1.3	4.0	2.0	0.2	-1.2	-1.1	1.1	-0.9	-1.6	0.9	1.2
Comparative height size at age 10	1.1	6.0	28.4	1.0	1.1	2.0	2.6	5.3	-0.3	0.3	4.0	1.6
Medication: Aspirin	1.1	1.4	5.7	0.4	-1.0	-1.3	-1.2	-0.5	-1.6	-2.4	-1.1	-0.4
Schizophrenia (2018)	1.0	2.2	10.6	-1.4	0.6	2.2	3.3	-0.6	-0.9	1.2	0.8	0.9
Breast Cancer	1.0	2.3	7.1	-0.4	0.1	-2.7	-2.5	-1.5	-1.6	-1.9	-0.2	-1.1
Fasting Glucose	1.0	1.2	4.2	0.1	1.4	1.5	2.0	-0.5	-1.1	1.3	-0.1	0.7
Ulcerative Colitis	1.0	1.5	6.1	0.3	1.0	0.5	1.7	-1.4	-2.5	-1.3	0.1	0.7
Type 2 Diabetes (T2D) (2018)	1.0	1.8	6.3	-0.3	-1.0	-0.9	0.2	-1.8	-2.2	-1.3	-2.5	-0.5
Current tobacco smoking	1.0	1.7	7.5	0.4	-1.6	0.9	-0.7	2.3	2.7	0.1	-0.0	-0.3
Fed-up feelings	1.0	1.9	8.9	3.0	-0.8	0.7	-1.0	2.3	0.9	-0.8	0.5	0.9
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	4.0	1.7	-0.5	0.1	-0.1	1.9	0.9	2.0	0.2	0.4
Waist circumference	1.0	3.8	25.1	1.6	-0.9	-0.7	-1.8	2.0	-1.0	-5.0	-0.3	-1.0
Hair/balding pattern: Pattern 2	1.0	1.3	3.1	1.2	1.1	-1.6	-0.5	-1.2	-1.8	-1.7	-0.0	0.7
Mouth/teeth dental problems	1.0	1.5	4.8	-1.1	1.4	0.6	1.8	-1.5	-0.5	2.2	-0.3	-0.7
Weight	1.0	4.9	23.8	1.8	0.7	1.8	-0.0	4.9	0.4	-2.4	3.2	1.5
Happiness	1.0	1.2	5.1	-1.1	-1.0	-0.8	-2.2	1.2	1.5	-0.6	-0.1	-0.4
Lung cancer (father)	1.0	1.1	5.3	-0.4	2.3	-0.3	0.6	-0.5	-1.4	-0.1	1.3	1.2
Headache pain in last month	1.0	1.7	4.7	-2.1	-1.8	1.2	0.1	0.5	2.2	0.6	-1.0	-1.2
Emphysema/chronic bronchitis	1.0	1.1	4.4	-2.1	1.3	0.8	0.4	-1.1	0.7	1.0	0.8	1.0
Mean time to correctly identify matches	1.0	2.0	7.6	0.7	0.6	2.2	1.5	-0.4	-0.1	2.8	1.6	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.5	0.2	-1.6	-0.2	-0.7	1.3	1.2	-1.5	-1.6	-1.1
Osteoarthritis (self-reported)	1.0	1.3	5.3	-1.5	0.3	1.7	0.7	-0.4	0.0	2.3	1.0	1.1
Bipolar Disorder (2018)	0.9	1.4	3.6	-1.9	1.3	0.3	1.8	-1.2	-1.0	0.6	1.7	0.0
Alzheimer’s Disease (in mother)	0.9	1.1	3.3	-0.8	1.0	0.3	1.8	-1.8	0.7	1.2	-0.1	0.9
Cardiovascular Disease	0.9	3.0	11.8	0.3	0.6	-1.4	-1.1	-1.9	-3.1	-3.4	-1.0	-0.6
Pack years adult smoking proportion	0.9	1.4	4.8	1.1	-2.2	0.0	-1.1	1.1	2.0	0.2	-1.2	0.1
Sitting height	0.9	6.2	25.4	1.4	2.1	2.3	2.2	5.0	0.6	2.5	3.6	0.9
Hip circumference	0.9	3.8	10.2	2.7	0.8	2.1	0.6	2.8	-0.5	-1.8	3.2	2.0
Forced vital capacity (FVC), Best measure	0.9	3.2	17.1	-0.7	1.9	0.7	0.5	4.1	0.0	-0.2	2.7	1.7
Pulse wave peak to peak time	0.9	1.1	4.2	-0.2	0.4	1.0	0.4	2.1	0.7	-0.9	1.6	1.2
Medication: Omeprazole	0.9	1.0	3.6	-0.1	1.2	0.4	0.8	0.0	-1.4	0.3	1.4	1.9
Number of full sisters	0.9	1.1	3.9	0.3	0.2	-0.9	0.9	-1.8	0.2	-0.7	-2.0	-1.4
Medication: Aspirin	0.9	1.2	3.0	0.5	-1.1	-1.3	-0.8	-0.6	-1.4	-1.7	-1.5	-0.3
Commuting to job workplace: Walk	0.9	1.0	3.3	-1.8	-0.9	1.0	-1.0	0.6	0.7	0.8	0.7	-1.1
Guilty feelings	0.9	1.4	5.0	1.3	-2.2	-0.2	-1.6	0.0	1.5	-0.4	-1.4	-0.3
Commuting to job workplace: Public transport	0.9	1.1	2.7	0.5	-0.8	-1.0	-1.1	1.6	-0.3	-1.2	-1.6	-1.1
Diastolic blood pressure, automated reading	0.9	2.8	12.9	3.6	2.4	-0.4	0.4	0.1	-2.9	-0.5	0.7	0.2
Pack years of smoking	0.9	1.4	4.7	1.0	-2.2	-0.1	-1.4	0.9	1.9	-0.1	-1.3	0.3
Depressed Affect (Nagel 2018)	0.8	1.7	10.1	3.2	-1.0	0.1	-1.7	1.5	0.5	-0.3	-0.5	0.1
Alzheimer’s Disease (including proxy)	0.8	1.2	5.0	-1.3	-0.4	-0.8	0.6	-2.2	1.2	0.7	-1.3	0.5
LDL Cholesterol	0.8	1.2	3.1	-1.3	-1.2	-1.3	-1.8	-0.5	1.2	-0.6	-1.1	-0.9
Lupus	0.8	1.2	3.6	-0.2	1.6	0.6	1.9	-0.4	-0.4	1.4	1.3	1.4
Rheumatoid Arthritis	0.8	1.2	4.1	0.7	0.9	0.2	2.0	-0.9	-1.0	2.0	0.4	0.4
Schizophrenia (2014)	0.8	1.7	5.4	-2.2	-0.3	2.3	2.2	-0.6	-0.7	0.6	0.4	0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.1	1.4	0.7	-0.6	1.3	0.0	-1.5	1.3	-1.0	0.0
Lung FEV1/FVC ratio	0.8	4.2	11.1	2.4	1.4	-3.3	-1.6	0.6	-2.9	-3.3	-0.7	-0.6
Number of treatments/medications taken	0.8	1.4	3.5	0.9	1.0	1.2	1.9	0.0	-1.7	-0.2	1.0	1.8
Average weekly fortified wine intake	0.8	1.0	4.8	0.5	1.3	-0.9	-0.6	0.4	-1.0	0.2	2.2	1.0
High blood pressure	0.8	2.1	7.3	2.5	0.3	-1.2	0.2	-1.5	-2.7	-1.5	-1.0	-0.7
Medication: Atenolol	0.8	1.0	5.3	2.3	0.1	-0.9	-0.0	0.5	-1.7	0.4	0.0	0.6
Number of live births	0.8	1.2	2.6	1.5	0.8	-1.3	0.2	-0.4	-1.3	-0.7	-1.5	-1.6
Illnesses of mother	0.8	1.0	4.1	-0.2	-2.0	0.6	-1.2	1.5	1.3	0.3	0.2	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	15.5	0.3	1.6	-0.8	-0.5	3.9	-0.6	-0.8	1.8	1.1
Exposure to tobacco smoke at home	0.8	0.9	3.1	0.1	-1.2	1.8	0.5	0.4	1.7	0.1	-0.9	-0.0
Ever highly irritable/argumentative for 2 days	0.8	1.0	2.9	-0.7	0.6	1.4	1.1	-0.1	-0.8	1.3	1.7	0.6
High blood pressure (siblings)	0.8	1.2	3.9	1.8	0.7	-0.2	1.1	-1.5	-2.0	0.1	-0.5	0.2
Worry too long after embarrassment	0.8	1.3	3.5	-1.2	-0.8	-1.6	-1.0	-1.0	-0.8	-0.5	-1.9	-1.3
Medication: Blood pressure	0.8	1.4	7.0	1.3	0.4	-0.9	1.0	-1.7	-2.6	-0.2	0.3	0.7
Hypertension (Self-reported)	0.8	2.1	6.6	1.9	-0.0	-1.1	0.2	-2.0	-2.6	-1.6	-1.3	-1.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.8	-1.3	1.4	1.1	0.3	0.5	-0.6	-0.5	2.0	0.5
Qualifications: nursing, teaching	0.8	1.2	7.5	-1.3	-0.1	-0.9	0.3	-2.7	-0.5	1.0	-0.5	-0.1
Smoking status: Current	0.8	1.2	5.6	0.6	-1.2	0.9	-0.1	1.9	2.4	0.3	-0.1	-0.3
Ever taken oral contraceptive pill	0.8	0.9	3.0	-1.7	-0.6	-0.4	-0.2	-0.8	0.2	-0.7	-1.6	-1.4
Financial situation satisfaction	0.8	1.0	2.9	0.0	1.3	0.9	0.9	-0.2	0.0	1.0	1.7	1.7
Medication: Paracetamol	0.8	1.3	6.3	0.0	0.0	2.5	0.8	1.0	1.3	0.4	1.0	1.3
Vascular/heart problems diagnosed by doctor	0.8	2.3	8.2	-2.1	-0.1	1.1	-0.0	1.4	2.9	1.9	1.5	1.1
Worry (Nagel 2018)	0.7	1.4	6.8	-0.5	1.1	-0.0	1.1	-2.6	-1.7	1.0	-0.6	-0.3
Crohns Disease (2012)	0.7	1.1	4.2	-1.2	0.8	1.0	2.1	-1.8	-1.0	0.0	-0.2	0.0
Triglycerides	0.7	1.1	3.9	-1.3	-0.4	-1.1	-0.2	-1.7	-0.3	-0.3	-2.0	-1.0
Hypothyroidism (self reported)	0.7	1.6	7.0	0.1	1.1	-1.5	-1.5	0.9	-1.1	-2.6	-0.1	-1.0
Respiratory disease	0.7	1.5	4.0	-1.3	1.1	1.1	1.2	-2.0	-1.1	0.6	0.9	1.6
Taking other prescription medications	0.7	1.1	3.6	0.5	1.2	1.1	1.9	-0.1	-1.3	0.2	1.1	1.3
Impedance of leg (left)	0.7	3.2	7.1	-2.1	0.6	-2.2	-1.8	-1.8	-1.5	-0.6	-2.7	-2.5
Past tobacco smoking	0.7	1.3	5.0	0.4	2.2	0.9	0.9	0.4	-2.0	1.2	0.4	0.2
Illnesses of siblings	0.7	1.0	3.9	-1.4	1.0	-0.1	-0.7	1.0	1.0	-0.7	2.0	0.6
Impedance of arm (right)	0.7	3.1	12.0	-1.8	-0.1	-0.4	-1.8	-1.6	-0.6	-0.8	-2.9	-3.5
Time employed in main current job	0.7	0.8	2.9	1.7	-1.1	-0.1	-0.2	0.8	1.3	0.9	0.1	-0.8
Noisy workplace	0.7	0.9	2.1	0.3	1.0	1.2	1.1	0.6	-1.1	0.8	0.8	1.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.8	0.1	-1.3	-0.9	-0.6	-0.7	1.4	0.2	-1.2	-1.1
Heart disease (mother)	0.7	0.8	2.8	-0.2	0.7	-0.5	-0.6	-0.3	-1.2	-1.4	0.8	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.9	3.2	1.1	-1.8	0.3	0.0	0.0	0.6	0.7	-1.0	-1.6
Chest pain or discomfort	0.7	1.0	2.8	-0.2	-0.4	1.7	0.8	-0.7	0.7	1.4	1.1	1.3
Friendships satisfaction	0.7	0.9	3.0	-0.7	-0.0	0.1	-1.7	0.3	-0.1	-1.7	1.1	1.0
Miserableness	0.7	1.3	6.8	0.8	-0.8	-0.4	-1.9	0.9	0.1	-2.6	-0.2	-0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	4.3	0.5	0.9	0.5	1.0	-0.9	-2.1	0.2	0.5	0.7
Illnesses of father: High blood pressure	0.7	0.9	4.4	0.5	-0.7	0.3	-1.2	2.1	0.6	-0.9	1.1	0.5
Risk taking	0.7	1.1	3.7	-1.3	-0.1	-1.7	-1.9	-0.3	-0.0	-0.0	-1.4	-0.6
Alcohol drinker status: Previous	0.7	0.9	3.1	-1.5	-0.7	0.7	0.8	-1.8	-0.6	-0.8	-0.5	0.5
Impedance of whole body	0.7	3.3	9.2	-2.0	0.1	-1.5	-2.2	-1.8	-1.1	-0.4	-2.8	-3.0
Irritable Bowel Disease (IBD)	0.6	1.5	3.5	-1.4	1.9	1.0	1.3	0.0	-1.8	-0.1	1.5	1.1
Ulcerative Colitis (UC)	0.6	1.2	4.3	-0.4	1.2	0.9	1.1	-0.6	-2.1	-0.7	1.4	1.0
Severe depression (siblings)	0.6	0.7	1.6	1.3	0.9	0.1	0.9	0.9	-0.7	1.1	0.8	0.7
Impedance of leg (right)	0.6	2.8	6.4	-2.1	0.7	-1.8	-2.0	-1.7	-1.1	-0.3	-2.2	-2.5
Trunk fat percentage	0.6	2.4	15.5	0.9	-0.0	0.1	-2.0	1.0	-1.3	-3.9	-0.6	-0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	4.8	-2.2	0.3	0.3	-0.4	-0.7	0.3	-0.6	0.6	-0.4
Qualifications: CSEs or equivalent	0.6	0.8	3.7	-0.3	0.5	-0.8	-1.0	-0.1	1.4	-1.9	-0.7	-0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.5	-0.0	-0.8	-0.6	0.2	-0.7	0.7	0.2	-1.6	-1.5
Trunk fat mass	0.6	2.4	11.3	1.1	0.2	0.9	-1.4	2.7	-0.5	-3.4	0.9	0.0
Number of incorrect matches in round	0.6	0.9	3.4	0.1	-0.6	0.6	1.2	-1.8	-0.8	1.8	-0.1	-0.2
Alcohol usually taken with meals	0.6	0.9	3.7	1.4	0.9	-0.4	-0.5	0.2	-1.3	0.7	1.9	0.6
Nervous feelings	0.6	1.1	3.2	0.7	1.3	-0.9	0.3	-1.6	-1.8	0.8	-1.0	-0.1
Hearing difficulty/problems with background noise	0.6	1.0	2.6	0.8	-0.0	0.8	-1.3	0.0	1.0	1.4	1.0	1.6
Had menopause	0.6	0.7	2.9	1.7	-0.3	-0.9	-0.7	1.3	0.7	-0.8	0.3	0.2
Allergy	0.6	1.4	3.5	-0.6	-1.4	-1.1	-1.9	0.8	0.9	-0.3	-1.4	-1.8
Medication: Simvastatin	0.6	0.9	2.1	0.2	-0.8	-0.5	-1.4	-1.4	-1.0	-1.4	-1.0	0.1
Falls in the last year	0.6	0.9	5.4	-0.4	-0.0	2.3	0.8	-0.2	-0.1	-0.3	1.4	0.4
Hair/balding pattern: Pattern 3	0.6	0.9	5.5	-1.1	-0.5	-0.3	-0.9	-0.5	-0.4	-2.3	-0.4	-0.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.6	0.2	-0.5	-0.6	-0.3	-1.3	-0.2	1.2	-1.3	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	1.0	1.9	0.9	-1.2	1.4	-0.9	0.2	1.4	-1.2	-0.3	-1.1
Peak expiratory flow (PEF)	0.6	1.3	7.0	-0.3	1.2	-0.0	-0.2	2.6	-0.7	-0.4	1.8	0.5
Medication: Paracetamol	0.6	1.0	3.9	0.3	-0.0	2.0	0.3	1.2	1.4	0.7	0.9	1.2
Birth weight	0.6	1.3	6.9	-0.2	-1.4	0.7	-0.2	2.6	1.6	0.1	0.6	-0.7
Body fat percentage	0.6	2.5	17.2	0.8	0.3	0.0	-2.1	0.6	-1.4	-4.2	-0.5	-0.6
Leg fat percentage (right)	0.6	2.1	14.0	0.7	0.5	-0.1	-2.0	0.1	-1.4	-3.7	-0.2	-0.4
Exposure to tobacco smoke outside home	0.6	0.8	2.9	-1.0	-0.8	1.1	0.7	-0.7	-0.4	-1.0	-1.7	-0.0
Number of full brothers	0.6	0.7	2.9	-1.7	-0.1	0.8	0.8	-0.5	0.7	0.2	-1.3	-0.7
Number of children fathered	0.6	0.7	5.4	0.1	-0.4	0.4	0.6	-0.6	0.6	2.3	-0.4	0.1
Whole body fat mass	0.6	2.3	10.5	1.2	0.3	0.9	-1.2	2.7	-0.4	-3.2	1.1	0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.2	0.4	0.8	-1.1	-1.0	0.7	-1.0	-1.5	0.7	-0.6
Supplements: Vitamin C	0.6	0.7	4.6	-2.2	0.5	0.4	-0.2	-1.0	0.1	-0.9	0.3	0.1
Illnesses of father: Heart disease	0.6	0.8	3.1	0.4	-0.7	0.6	-1.5	1.8	1.1	-0.3	-0.0	-0.4
Average weekly red wine intake	0.6	0.9	3.7	0.7	1.3	0.0	0.6	-0.9	-1.9	0.5	0.3	-1.3
Loneliness, isolation	0.6	0.8	2.7	1.1	-1.5	-0.4	-1.6	0.8	0.2	-0.7	-0.6	0.8
Diabetes diagnosed by doctor	0.6	1.0	2.5	0.4	-1.1	-0.8	-0.8	-1.3	-1.6	-0.8	-1.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.2	1.8	0.7	0.7	1.8	1.1	-0.2	0.6	0.1	0.4
Medication: Gliclazide	0.6	0.6	1.9	1.1	-1.2	-0.2	-0.1	0.0	-1.0	0.4	-0.7	1.4
Average weekly champagne plus white wine intake	0.6	0.8	4.6	-0.4	0.4	-0.3	0.2	-0.3	-1.4	-2.1	0.8	-0.4
Hearing aid user	0.6	0.7	2.5	-0.5	0.1	1.1	0.9	-0.7	1.6	0.5	-1.2	-0.2
Medication: Blood pressure	0.6	1.2	3.6	1.2	-0.5	-0.3	-1.1	0.3	-0.5	-1.9	-1.5	-1.8
Leg fat percentage (left)	0.6	2.2	15.3	0.7	0.6	-0.2	-1.6	0.0	-1.7	-3.9	-0.4	-0.1
Unable to work because of sickness or disability	0.6	0.8	2.8	-0.5	0.7	1.7	1.5	0.2	-0.1	0.7	0.6	1.2
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	3.7	0.1	1.3	-0.2	0.5	0.1	-1.9	-0.5	0.6	0.7
Leg fat mass (left)	0.6	2.2	11.0	0.9	0.9	1.1	-0.5	1.9	-0.9	-3.3	1.4	1.1
HbA1C	0.5	0.5	2.4	0.7	0.8	0.3	1.5	-0.7	-0.6	-0.1	-0.6	-0.7
Systolic Blood Pressure	0.5	2.7	7.3	2.7	0.9	-0.5	0.4	0.5	-2.7	-2.4	-0.6	-2.0
Neuroticism	0.5	1.1	3.1	1.8	-0.4	-1.3	-1.2	-0.7	-0.7	-0.5	-1.7	-0.6
Sensitivity / hurt feelings	0.5	0.9	3.3	1.8	-1.2	-0.9	-0.7	-0.6	-1.1	-0.7	-0.9	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	3.7	-0.7	-1.0	-0.3	-1.9	0.1	1.1	-0.8	0.1	0.3
Serious illness, injury or assault to yourself	0.5	0.6	1.5	1.0	-1.0	1.2	0.7	0.6	0.9	0.6	0.1	0.4
High blood pressure (mother)	0.5	0.8	2.3	1.3	0.9	0.6	0.7	0.5	-0.4	-0.9	-0.8	-1.5
Qualifications: None of the above	0.5	1.0	4.8	0.1	0.6	1.8	0.3	0.3	0.7	2.2	0.3	1.1
Financial difficulties in last 2 years	0.5	0.7	2.3	0.6	-1.4	1.2	0.2	-0.0	1.5	0.5	-0.7	0.5
Arm fat percentage (right)	0.5	1.9	15.0	0.4	0.2	0.5	-1.6	-0.2	-0.9	-3.9	-0.4	-0.4
Pulse rate	0.5	0.8	2.9	-0.6	0.5	0.1	0.7	-1.2	0.5	1.7	-0.4	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.9	1.4	-1.3	-0.1	0.0	0.5	1.3	0.4	0.5	0.1
Impedance of arm (left)	0.5	2.5	9.6	-1.7	-0.4	-0.7	-2.0	-1.2	-0.6	-1.1	-2.3	-3.1
Arm fat mass (right)	0.5	2.0	9.7	1.0	0.5	1.2	-0.8	2.1	-0.3	-3.1	1.3	0.8
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	1.7	-1.0	0.1	-1.3	-0.2	-1.2	-1.2	-1.3	-0.6	-0.9
Comparative body size at age 10	0.5	1.4	3.2	-0.8	1.0	0.9	0.9	-0.5	-1.8	-1.8	1.7	1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.1	1.7	-0.5	0.9	0.9	0.5	0.9	0.3	-0.2	-0.2
Leg fat mass (right)	0.5	2.0	10.6	0.8	0.7	1.1	-0.8	1.9	-0.8	-3.2	1.3	0.8
Commuting to job workplace: Car/motor vehicle	0.5	0.5	4.2	-0.2	-0.2	-0.2	0.2	-2.1	0.5	0.2	-0.3	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.8	-1.0	1.4	-0.4	0.4	-0.4	-1.2	0.0	-1.0	-0.5
Arm fat percentage (left)	0.5	2.1	16.6	0.5	0.2	0.4	-1.8	0.2	-1.0	-4.1	-0.2	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.9	-0.5	-0.3	-0.7	-1.0	-0.4	-1.0	0.0	-0.2	-1.7
Illnesses of father: None of the above (group 1)	0.5	0.6	1.9	-0.9	0.5	1.1	1.4	-0.2	0.2	1.3	-0.1	0.5
Arm fat mass (left)	0.5	2.1	9.1	1.0	0.4	1.3	-0.7	2.3	-0.1	-3.0	1.4	0.9
Number of self-reported non-cancer illnesses	0.5	0.9	3.2	0.8	1.1	0.6	1.1	0.4	-1.8	0.8	1.0	1.1
Pain type(s) experienced in last month: Hip pain	0.5	0.6	3.0	0.2	-0.6	1.7	0.5	-0.5	-0.8	-0.3	0.8	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	0.4	-0.8	-0.0	-1.0	1.4	0.7	-1.2	0.5	0.5
Alzheimer’s Disease (in father)	0.4	0.5	2.5	-0.9	-0.4	-0.3	-0.9	-0.4	0.2	-1.6	-0.5	-0.3
Lung FVC	0.4	1.9	5.2	-1.9	1.5	1.0	1.0	1.3	0.7	1.1	2.3	1.6
Angina	0.4	0.5	1.6	-1.2	0.2	-0.2	-0.4	0.2	-1.3	-0.9	0.7	0.4
Townsend deprivation index at recruitment	0.4	0.6	2.6	0.2	-0.9	0.2	-0.8	-0.1	0.5	-1.6	-1.2	0.1
Hayfever, allergic rhinitis or eczema	0.4	0.8	4.2	2.0	0.3	-0.2	1.1	-0.9	-1.0	0.2	-0.0	0.8
Body mass index (BMI)	0.4	1.5	8.9	1.3	0.4	0.7	-0.5	0.9	-0.7	-3.0	1.1	1.2
Had other major operations	0.4	0.5	3.6	1.9	-0.6	-0.8	-0.1	0.5	0.1	0.3	-0.5	-0.6
Fluid intelligence score	0.4	0.7	2.0	-0.3	0.9	-1.4	0.8	0.6	-1.0	-1.1	-0.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	3.3	0.3	-0.0	0.5	0.0	0.4	0.2	1.0	1.3	1.8
Prospective memory result	0.4	0.4	1.3	-0.7	-0.1	0.4	0.1	-0.9	-0.9	-1.1	0.4	-0.7
Length of working week for main job	0.4	0.5	2.2	-0.1	-0.6	-0.2	-0.3	0.1	0.5	-0.9	-1.0	-1.5
Tense / ‘highly strung’	0.4	0.7	3.9	0.6	0.5	-0.0	0.8	-2.0	-1.0	-0.1	-0.9	-0.7
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	-0.1	-1.3	-0.3	0.6	0.8	1.3	1.5	-0.8	-1.2
Loud music exposure frequency	0.4	0.4	2.5	0.0	-0.2	0.5	-0.8	0.4	-0.3	-1.6	-0.1	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	2.2	0.3	0.6	-0.5	0.2	-1.5	-1.2	0.0	0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	0.3	-0.7	1.1	-0.3	1.2	1.3	-0.4	0.4	0.5
Health satisfaction	0.4	0.5	2.0	-1.3	-0.8	0.4	0.2	-0.4	0.0	1.4	-0.0	0.3
Medication: Ibuprofen	0.4	0.5	1.7	0.7	-0.6	0.4	0.3	0.5	1.3	1.0	0.9	0.3
Suffer from ‘nerves’	0.4	0.6	1.7	-1.3	1.2	-0.8	-0.4	-0.4	-0.9	-0.2	-0.8	0.4
Family relationship satisfaction	0.4	0.5	1.0	-1.0	-0.5	0.7	-0.8	0.8	0.7	0.1	0.5	0.9
Breast cancer (self-reported)	0.4	0.5	1.7	0.3	-0.7	1.1	0.9	-0.2	1.3	0.1	-0.7	0.1
Asthma (self-reported)	0.4	0.8	2.0	-0.6	1.3	0.5	1.2	-0.8	-1.4	0.6	0.8	1.2
Ever smoked	0.4	0.6	2.7	-0.4	-1.3	0.2	0.9	-0.3	1.6	-0.1	-0.0	0.8
Irritability	0.4	0.7	2.2	0.8	-1.4	-0.3	-0.9	0.2	0.7	-0.4	-1.5	-0.5
Age started oral contraceptive pill	0.4	0.5	1.9	0.9	0.1	-1.4	-0.5	-0.2	-0.6	-1.1	-0.1	0.4
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.9	-0.1	-0.3	-2.0	-0.1	-0.3	-0.3	-0.5	-1.2	-1.9
Neuroticism (Nagel 2018)	0.3	0.8	2.4	1.5	-0.8	-0.3	-1.1	-0.8	-0.3	0.5	-1.4	-0.6
Crohns Disease (2017)	0.3	0.7	3.0	-1.7	0.9	0.8	1.2	0.6	0.1	1.1	0.3	0.3
Ovarian Cancer	0.3	0.4	2.2	-1.5	-0.3	-0.6	-0.2	-0.2	-0.6	-0.9	0.1	-0.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.6	-0.8	1.0	0.3	0.7	-0.6	-0.3	0.1	1.3	-0.3
BMI	0.3	1.7	10.0	0.4	0.5	0.7	-0.7	-0.7	-1.5	-3.2	1.2	1.5
Frequency of depressed mood in last 2 weeks	0.3	0.4	2.7	-0.2	0.3	0.6	0.9	-0.1	-0.2	0.1	0.6	1.6
Hearing difficulty/problems: Yes	0.3	0.5	1.7	0.8	0.2	0.8	1.0	-0.3	0.6	0.9	0.4	1.3
Vitamin and mineral supplements	0.3	0.4	2.0	0.2	0.4	-0.4	-0.4	0.9	-0.2	-0.5	-0.2	-1.4
Diabetes (father)	0.3	0.4	1.9	-0.3	0.3	-0.5	0.5	-0.5	-1.4	0.1	-0.2	0.9
Chronic bronchitis/emphysema (father)	0.3	0.3	0.7	-0.4	0.5	-0.9	0.5	-0.8	-0.7	-0.8	0.2	0.3
Qualifications: A levels/AS levels or equivalent	0.3	0.8	3.2	-1.8	0.3	0.6	1.1	-1.3	-0.9	-0.3	-0.0	0.3
Asthma	0.3	0.7	1.7	-0.5	1.0	0.6	1.0	-0.5	-0.9	0.5	0.8	1.3
Depression (self-reported)	0.3	0.3	1.5	-0.2	-0.6	0.5	0.2	0.1	1.2	-0.9	0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.7	0.3	1.2	-0.7	-0.4	0.9	-0.4	-1.3	0.2	-1.3
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.8	-0.5	1.3	-0.3	0.5	0.0	-0.4	0.1	1.1	0.2
Angina (self-reported)	0.3	0.3	1.2	-0.9	0.2	-0.7	-0.6	0.2	-1.1	-0.7	0.2	-0.1
Migraine (self-reported)	0.3	0.4	1.4	0.6	0.6	0.2	0.3	0.1	-0.9	-0.8	-0.6	-1.2
Alcohol intake frequency.	0.3	0.7	2.1	-0.3	-0.1	-0.7	-0.6	-0.3	-1.4	-1.4	-1.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	3.3	-0.1	-0.4	-0.7	-1.3	1.8	0.5	-0.7	-0.5	-0.0
Mother’s age at death	0.3	0.4	2.0	0.8	-0.2	-0.3	-0.7	0.5	-0.5	0.1	1.4	0.3
Alcohol drinker status: Never	0.3	0.4	2.2	-0.5	1.5	0.3	0.4	0.0	-0.5	0.7	0.3	0.5
Average weekly beer plus cider intake	0.3	0.4	2.5	-0.4	0.6	0.8	0.4	0.1	-0.0	-0.4	0.6	1.6
Heart disease (siblings)	0.3	0.4	0.9	-0.1	-0.8	0.9	0.2	0.4	0.2	-0.8	-0.9	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.7	-0.5	-0.2	-1.6	-0.4	0.4	0.0	-0.2	-0.5	-1.4
Age at First Birth	0.2	0.3	1.0	0.4	-0.6	-0.0	-0.7	1.0	0.4	-0.4	0.6	-0.5
HDL Cholesterol	0.2	0.3	1.2	0.6	0.5	0.5	0.5	0.4	-0.5	1.1	0.2	0.2
Blood Eosinophil Count	0.2	1.5	7.1	-0.3	-0.3	-1.4	1.5	-2.7	-1.2	1.2	-0.7	0.6
Allergy or Eczema	0.2	0.6	2.2	1.5	-0.2	-0.2	0.8	-0.9	-1.0	0.6	-0.1	1.1
Hair Pigment	0.2	6.9	15.1	1.1	1.2	3.9	3.4	2.2	1.0	3.1	3.1	3.9
Medication: Co-codamol	0.2	0.2	1.1	-0.3	1.1	0.5	0.1	0.1	0.1	0.8	0.2	0.6
Multivitamins +/- minerals	0.2	0.2	0.9	0.0	0.0	-0.5	-0.4	-0.7	-0.4	-0.1	0.3	1.0
Neuroticism score	0.2	0.5	1.6	1.3	-0.3	-0.7	-1.2	-0.1	-0.7	-0.7	-0.5	0.4
Father’s age at death	0.2	0.3	2.4	-0.2	0.3	-1.6	-0.3	-0.6	-0.0	-0.3	-0.2	-0.2
Medication: Lansoprazole	0.2	0.3	0.7	-0.8	-0.3	-0.7	-0.7	-0.3	0.1	-0.6	-0.7	-0.3
Breastfed as a baby	0.2	0.2	0.6	0.1	0.5	-0.1	-0.2	0.5	-0.4	-0.8	0.7	0.6
Wheeze or whistling in the chest in last year	0.2	0.4	2.0	-0.3	-0.4	0.1	-0.2	0.0	0.7	1.0	0.7	1.4
Medication for pain relief, constipation, heartburn	0.2	0.4	1.2	-0.9	1.1	0.1	0.7	-0.7	-0.8	-0.4	0.0	0.0
Medication: Bendroflumethiazide	0.2	0.3	1.1	0.2	0.2	0.2	0.2	-0.9	-0.1	-1.1	0.0	-0.7
Depression (Nagel 2018)	0.1	0.1	0.3	0.2	-0.3	0.2	-0.5	-0.4	0.2	-0.3	-0.3	0.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.8	0.2	-0.2	0.6	-0.3	0.9	-0.3	-0.3	-0.4	0.0
Major Depression (MDD)	0.1	0.1	0.6	0.0	-0.5	0.0	0.1	0.3	0.8	0.0	0.5	0.0
Blood Platelet Count	0.1	0.9	2.9	-1.4	0.1	1.0	-0.0	-0.9	1.0	1.7	1.1	0.5
Blood Red Count	0.1	1.1	5.2	1.3	-1.1	-0.8	-2.3	0.0	0.6	-0.6	-1.1	0.6
Tanning	0.1	1.6	3.9	0.7	-1.3	-1.6	-2.0	-1.5	0.8	1.3	-1.3	-1.3
Age when periods started (menarche)	0.1	0.3	1.6	-1.3	-0.3	-0.8	-0.4	-0.2	0.3	0.7	0.2	-0.3
Medication: Levothyroxine sodium	0.1	0.2	0.7	0.4	0.7	-0.8	0.0	0.4	-0.0	-0.9	0.4	-0.3
Worrier / anxious feelings	0.1	0.1	0.5	0.0	0.2	0.5	0.5	-0.3	-0.5	0.7	-0.3	0.2
Qualifications: College or University degree	0.1	0.3	0.7	-0.6	-0.5	-0.7	-0.4	-0.2	-0.8	-0.8	0.2	-0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

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