Best TWAS P=3.02e-10 · Best GWAS P=5.71e-12 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Colon Sigmoid | PSRC1 | 0.28 | 0.02 | enet | 17 | 0.07 | 1.8e-03 | -6.1 | 6.0 | 2.0e-09 | -0.59 | 0.03 | 0.83 | FALSE |
| 2 | GTEx | Testis | AMIGO1 | 0.19 | 0.18 | lasso | 6 | 0.16 | 1.2e-07 | -3.8 | -5.2 | 1.6e-07 | 0.27 | 0.94 | 0.01 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | AMIGO1 | 0.08 | 0.03 | blup | 404 | 0.03 | 8.7e-05 | -5.6 | -5.9 | 4.5e-09 | 0.35 | 0.90 | 0.05 | TRUE |
| 4 | YFS | Blood | GNAI3 | 0.43 | 0.44 | lasso | 11 | 0.50 | 2.3e-192 | -6.7 | 6.3 | 3.0e-10 | -0.94 | 0.01 | 0.99 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SYPL2 | 0.06 | 0.01 | blup | 45 | 0.04 | 5.3e-05 | -6.0 | 5.6 | 2.0e-08 | -0.28 | 0.01 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AMIGO1 | 0.09 | 0.07 | enet | 10 | 0.07 | 1.2e-07 | -3.8 | -5.3 | 9.4e-08 | 0.29 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | AMIGO1 | 0.24 | 0.14 | lasso | 2 | 0.14 | 1.1e-04 | -5.6 | -5.6 | 2.6e-08 | 0.22 | 0.06 | 0.18 | FALSE |