Hub : Genes

SYPL2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1260 0.0460 4.5e-04 0.001 NA 0.005 NA 0.003 2.3e-01 NA 1.2e-01 NA 1.7e-01
2 GTEx Artery Aorta 0.3530 0.0720 2.9e-08 0.234 NA 0.223 NA 0.272 3.9e-13 NA 1.6e-12 NA 2.6e-15
3 GTEx Artery Tibial 0.3033 0.0566 5.2e-13 0.221 NA 0.293 NA 0.304 3.3e-17 NA 3.0e-23 NA 3.7e-24
4 GTEx Brain Cerebellar Hemisphere 0.2760 0.0920 1.1e-04 0.039 NA 0.031 NA 0.089 3.6e-02 NA 5.5e-02 NA 2.7e-03
5 GTEx Brain Cerebellum 0.1560 0.0670 4.0e-03 0.020 NA 0.028 NA 0.027 8.4e-02 NA 5.1e-02 NA 5.2e-02
6 GTEx Colon Sigmoid 0.1480 0.0600 1.6e-03 0.059 NA 0.055 NA 0.052 3.8e-03 NA 5.2e-03 NA 6.3e-03
7 GTEx Esophagus Gastroesophageal Junction 0.2950 0.0770 2.8e-06 0.135 NA 0.185 NA 0.170 1.3e-05 NA 3.0e-07 NA 9.6e-07
8 GTEx Esophagus Mucosa 0.0970 0.0390 1.3e-03 0.001 NA 0.029 NA 0.020 2.6e-01 NA 4.5e-03 NA 1.7e-02
9 GTEx Esophagus Muscularis 0.3210 0.0570 1.1e-14 0.229 NA 0.368 NA 0.374 5.0e-14 NA 2.1e-23 NA 6.8e-24
10 GTEx Heart Atrial Appendage 0.3660 0.0800 1.1e-07 0.134 NA 0.242 NA 0.269 1.4e-06 NA 3.2e-11 NA 1.8e-12
11 GTEx Heart Left Ventricle 0.2943 0.0714 4.9e-07 0.068 NA 0.149 NA 0.134 1.6e-04 NA 2.5e-08 NA 1.3e-07
12 GTEx Liver 0.3420 0.0900 4.1e-06 0.270 NA 0.283 NA 0.300 3.6e-08 NA 1.4e-08 NA 4.6e-09
13 GTEx Lung 0.2420 0.0516 2.2e-14 0.202 NA 0.279 NA 0.278 2.0e-15 NA 1.6e-21 NA 2.1e-21
14 GTEx Muscle Skeletal 0.2042 0.0446 6.2e-14 0.210 NA 0.194 NA 0.213 2.6e-20 NA 9.8e-19 NA 1.5e-20
15 GTEx Nerve Tibial 0.0889 0.0371 7.1e-03 -0.003 NA 0.050 NA 0.002 6.2e-01 NA 1.9e-04 NA 2.1e-01
16 GTEx Ovary 0.3910 0.0830 8.3e-09 0.439 NA 0.433 NA 0.459 4.1e-12 NA 6.0e-12 NA 8.8e-13
17 GTEx Pancreas 0.2760 0.0660 1.3e-08 0.230 NA 0.122 NA 0.189 4.1e-10 NA 8.3e-06 NA 2.0e-08
18 GTEx Stomach 0.2320 0.0640 3.1e-07 0.184 NA 0.185 NA 0.210 3.6e-09 NA 3.0e-09 NA 2.3e-10
19 GTEx Testis 0.4480 0.0590 0.0e+00 0.501 NA 0.541 NA 0.533 3.3e-25 NA 5.0e-28 NA 1.9e-27
20 GTEx Uterus 0.2870 0.1060 2.8e-03 0.132 NA 0.015 NA 0.042 1.3e-03 NA 1.6e-01 NA 5.0e-02
21 METSIM Adipose 0.0592 0.0175 4.5e-08 0.055 0.051 0.045 0.051 0.050 1.1e-08 4.3e-08 2.2e-07 4.3e-08 4.3e-08
22 ROSMAP Brain Pre-frontal Cortex 0.0262 0.0152 2.3e-02 0.011 0.006 0.006 0.008 0.012 1.4e-02 5.2e-02 5.6e-02 3.1e-02 9.8e-03
23 TCGA Breast Invasive Carcinoma 0.0610 0.0251 6.7e-15 0.066 0.079 0.073 NA 0.071 2.0e-13 8.5e-16 8.4e-15 NA 2.2e-14
24 TCGA Head and Neck Squamous Cell Carcinoma 0.0316 0.0209 8.3e-05 0.052 0.033 0.037 NA 0.046 1.6e-06 1.2e-04 5.0e-05 NA 6.6e-06
25 TCGA Kidney Renal Papillary Cell Carcinoma 0.0440 0.0310 8.1e-03 0.043 0.036 0.027 NA 0.036 1.7e-03 3.6e-03 1.0e-02 NA 3.6e-03
26 TCGA Brain Lower Grade Glioma 0.0613 0.0354 1.4e-04 0.010 0.036 0.036 NA 0.024 2.1e-02 5.3e-05 5.8e-05 NA 8.4e-04
27 TCGA Liver Hepatocellular Carcinoma 0.1820 0.0990 6.1e-08 0.187 0.184 0.171 NA 0.182 3.5e-09 4.7e-09 1.8e-08 NA 6.1e-09
28 TCGA Lung Adenocarcinoma 0.0892 0.0344 5.6e-16 0.138 0.129 0.145 NA 0.143 8.3e-16 8.0e-15 1.3e-16 NA 2.5e-16
29 TCGA Lung Squamous Cell Carcinoma 0.0489 0.0242 3.5e-07 0.060 0.057 0.045 NA 0.049 2.2e-07 4.4e-07 7.2e-06 NA 2.9e-06
30 TCGA Prostate Adenocarcinoma 0.0776 0.0372 7.8e-12 0.078 0.098 0.071 NA 0.093 1.6e-08 1.9e-10 6.8e-08 NA 5.4e-10
31 TCGA Stomach Adenocarcinoma 0.0470 0.0290 2.0e-03 0.019 0.031 0.004 NA 0.019 1.4e-02 2.6e-03 1.5e-01 NA 1.4e-02
32 TCGA Thyroid Carcinoma 0.0670 0.0380 3.5e-05 0.036 0.031 0.017 NA 0.020 1.8e-04 4.9e-04 8.2e-03 NA 4.1e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32
Bipolar Disorder (2018) 3.5 5.6 8.3 2.5 2.6 2.7 2.4 2.2 2.7 2.4 2.8 2.9 2.7 2.7 2.0 2.8 2.2 0.3 -2.3 2.4 2.2 -2.4 -2.6 2.3 2.7 1.9 2.3 -2.2 1.9 2.6 2.3 2.1 2.4 2.1 -1.6
Bipolar Disorder or Schizophrenia 0.9 2.3 4.2 1.7 2.0 1.9 1.4 1.1 1.5 1.5 1.9 2.1 1.9 1.4 1.2 1.7 0.8 1.1 -1.4 1.4 1.0 -1.5 -1.4 1.0 1.6 1.7 1.5 -1.5 1.9 1.3 1.5 1.6 1.2 1.5 -1.2
Depressed Affect (Nagel 2018) 0.7 1.5 6.5 -1.6 -1.7 -1.7 -0.2 -0.3 -1.1 -0.4 -1.0 -1.5 -1.8 -1.2 0.1 -1.2 -0.6 -2.5 0.3 -0.6 -0.5 0.3 1.2 -1.1 -1.6 -1.5 -0.3 1.4 -2.2 -0.4 -1.1 -1.4 -0.3 -1.5 -0.1
Depression (Nagel 2018) 0.2 0.3 1.5 -0.7 0.2 -0.0 0.7 0.4 -0.3 0.2 -0.0 0.4 0.0 -0.9 0.8 -0.2 -0.6 -1.2 -0.7 -0.0 0.4 -0.7 -0.2 0.3 -0.4 -0.0 0.7 0.1 -0.8 0.5 -0.1 0.1 0.1 -0.1 -1.2
Intelligence (Savage-Jansen 2018) 8.6 26.4 44.8 3.9 2.5 3.4 6.7 6.2 4.4 5.0 5.0 4.6 3.3 3.6 5.9 4.8 5.1 -0.6 -6.3 5.5 5.8 -6.3 -5.6 5.6 3.8 5.0 6.3 -5.5 3.7 6.4 5.5 5.5 6.1 5.4 -5.6
Neuroticism (Nagel 2018) 0.7 1.7 4.3 0.9 -0.7 -0.4 2.1 2.0 0.4 1.5 1.0 0.1 -0.6 -0.2 2.0 0.8 1.4 -1.3 -1.9 1.4 1.4 -1.8 -1.2 1.2 -0.1 1.0 1.7 -1.0 0.2 1.7 1.2 0.9 1.9 0.8 -2.0
Schizophrenia (2018) 0.1 0.2 1.6 0.1 0.4 0.2 -0.2 -0.4 -0.3 0.0 -0.0 0.3 0.3 -0.3 -0.1 -0.1 -0.8 1.3 0.1 -0.2 -0.5 0.0 0.3 -0.5 -0.1 0.6 0.0 -0.1 0.9 -0.4 -0.0 0.3 -0.4 0.3 -0.2
Schizophrenia vs Biploar Disorder 1.2 1.6 3.3 -1.8 -1.1 -1.4 -0.8 -1.3 -1.6 -1.4 -1.2 -1.5 -1.3 -1.6 -0.8 -1.5 -1.4 -0.4 1.3 -1.5 -1.8 1.3 1.3 -1.4 -1.5 -0.9 -1.1 1.0 -0.5 -1.3 -1.1 -1.0 -1.3 -0.8 0.9
Worry (Nagel 2018) 1.2 2.5 4.2 2.1 0.5 0.7 1.6 2.0 1.0 1.5 1.9 1.0 0.6 0.6 1.8 1.6 1.8 0.1 -1.9 1.5 1.8 -1.7 -1.9 1.7 1.1 1.9 1.7 -1.8 1.8 1.9 2.0 1.8 1.9 1.7 -1.7
Alzheimer’s Disease (in mother) 0.8 0.9 3.2 0.7 1.8 1.5 0.5 0.5 1.2 1.0 1.6 1.2 1.6 1.8 0.0 1.1 0.4 1.7 -0.4 0.4 0.5 -0.4 -0.0 -0.1 1.4 0.6 0.4 -0.6 0.7 0.4 0.6 0.5 0.4 0.7 -0.1
Alzheimer’s Disease (in father) 0.8 0.9 3.1 -1.8 0.1 -0.0 -1.3 -0.9 -0.4 -0.9 -0.3 -0.6 0.1 -0.3 -0.6 -0.5 -0.4 -0.7 1.2 -1.1 -0.8 1.3 0.8 -1.6 0.1 -1.2 -1.5 1.0 -1.1 -1.1 -0.9 -1.0 -1.0 -1.0 1.0
Alzheimer’s Disease (including proxy) 0.4 0.6 2.5 -0.9 1.6 1.3 -0.6 -0.5 0.6 0.3 1.0 0.8 1.4 1.4 -0.6 0.5 -0.2 0.9 0.5 -0.4 -0.4 0.5 0.9 -1.1 1.1 -0.6 -0.7 0.4 -0.5 -0.5 -0.2 -0.5 -0.5 -0.3 0.9
Crohns Disease (2017) 1.1 2.5 7.1 2.7 0.8 1.3 1.2 1.3 1.4 1.9 1.4 1.0 1.2 1.8 0.7 1.8 2.3 0.4 -1.2 1.6 1.3 -1.1 -2.2 1.8 1.8 1.3 1.2 -1.8 1.8 1.7 2.0 1.7 1.7 1.8 -0.7
Irritable Bowel Disease (IBD) 0.5 1.3 8.0 2.8 0.5 1.0 0.2 0.5 0.9 1.2 0.8 0.7 0.8 1.0 -0.2 1.4 2.0 -0.5 -0.7 1.6 0.7 -0.6 -1.4 1.4 1.5 0.5 0.8 -1.1 1.0 1.2 1.3 1.2 1.0 1.1 -0.1
Ulcerative Colitis (UC) 0.3 0.5 4.5 2.1 0.3 0.8 -0.2 -0.1 0.3 0.4 0.6 0.6 0.5 0.0 -0.6 1.0 1.4 -1.0 -0.3 1.5 0.3 -0.3 -0.4 0.8 1.1 -0.1 0.4 -0.3 0.1 0.6 0.5 0.7 0.4 0.5 -0.1
Major Depression (MDD) 2.8 3.4 6.7 1.7 0.9 1.1 2.2 2.1 1.1 1.3 1.1 1.5 1.1 0.6 2.2 1.4 1.4 -0.6 -2.2 1.3 1.7 -2.1 -2.6 1.9 1.1 2.5 2.1 -2.3 2.5 2.0 2.1 2.4 1.9 2.5 -2.3
Reaction Time 1.7 3.2 8.9 -1.9 -1.0 -1.2 -2.2 -1.5 -1.9 -1.5 -2.5 -1.4 -1.3 -1.8 -1.8 -1.6 -1.3 -3.0 1.5 -1.4 -1.0 1.5 2.0 -2.0 -1.2 -2.4 -1.4 2.0 -2.7 -1.2 -1.9 -1.7 -1.8 -1.9 0.8
Verbal and Numeric Reasoning (VNR) 6.8 16.4 27.4 2.2 2.3 2.9 5.1 5.0 3.6 4.4 4.0 4.0 2.8 3.2 4.5 4.0 3.8 -1.4 -5.2 4.5 4.5 -5.2 -3.8 3.8 3.1 3.7 5.2 -4.1 2.6 5.1 4.1 4.2 4.8 4.0 -4.7
Breast Cancer 1.7 4.0 7.5 -1.5 -1.7 -2.2 -1.7 -1.8 -2.6 -2.5 -2.6 -2.0 -2.0 -2.7 -1.4 -2.3 -2.4 0.1 1.8 -2.2 -1.9 1.8 1.2 -2.4 -2.2 -1.5 -1.9 2.1 -1.7 -2.3 -2.2 -2.0 -2.1 -2.1 0.8
Ovarian Cancer 0.5 0.7 3.0 -0.8 -0.8 -0.5 -1.5 -1.1 0.2 -1.0 0.0 -0.8 -0.6 -0.0 -1.2 -0.3 0.1 -0.0 1.0 -0.0 -0.6 1.0 1.2 -0.4 -0.2 -1.1 -0.9 0.7 -0.4 -0.7 -0.7 -0.7 -0.7 -0.7 1.7
Prostate Cancer 0.2 0.2 0.9 -0.4 1.0 0.5 0.1 0.4 0.1 -0.2 0.3 0.7 0.7 0.1 0.8 -0.0 -0.7 -0.5 -0.4 -0.5 0.2 -0.4 -0.8 0.1 0.1 0.3 0.6 0.1 -0.5 0.1 -0.1 -0.2 0.1 -0.3 -0.8
Age at First Birth 0.8 1.2 4.6 1.2 0.1 0.5 1.5 1.1 0.9 2.1 1.7 0.6 0.2 0.9 1.0 1.4 1.6 0.4 -1.2 1.7 0.6 -1.1 -1.4 0.2 0.8 0.6 1.1 -1.0 0.5 1.2 0.8 1.0 1.5 0.9 -0.9
Bipolar Disorder (2011) 2.0 2.0 8.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 2.1 -2.7 2.9 2.5 2.5 2.6 2.6 2.8 -1.8
Body Mass Index (BMI) (2010) 0.1 0.2 1.4 -0.6 0.3 -0.1 0.4 0.4 -0.5 -0.5 -0.0 -0.0 0.3 -0.2 1.2 -0.6 -0.8 -0.2 -0.2 -1.2 -0.2 -0.1 0.1 -0.1 -0.6 0.4 0.1 -0.1 0.0 -0.1 0.0 -0.1 -0.2 0.0 -0.6
Coronary Artery Disease (CAD) 1.7 2.1 8.8 -0.4 0.2 0.1 -2.0 -1.9 -0.2 -0.9 -0.6 -0.5 0.1 0.7 -3.0 -0.6 -0.8 2.3 1.7 -1.2 -1.5 1.8 1.8 -0.3 0.0 -1.9 -1.5 1.8 -1.4 -1.7 -1.4 -1.9 -1.4 -1.8 2.0
Crohns Disease (2012) 0.6 1.0 3.3 1.8 -0.1 0.2 0.9 1.0 0.5 1.2 0.4 0.1 0.1 0.6 0.2 1.1 1.8 0.7 -0.8 1.1 1.0 -0.7 -1.6 1.3 0.8 0.9 0.7 -1.1 1.4 1.1 1.4 1.1 1.3 1.1 -0.5
Mean Putamen Volume 1.0 1.1 2.9 0.3 -1.0 -0.8 -1.4 -1.4 -0.7 -1.5 -1.2 -1.1 -0.9 -0.3 -1.7 -0.6 -0.1 0.2 1.3 -0.2 -0.9 1.2 1.4 -0.8 -0.5 -1.7 -1.4 1.1 -1.0 -0.9 -0.9 -1.1 -1.1 -1.0 1.6
Fasting Glucose 1.5 1.8 6.1 0.8 0.6 0.7 1.9 1.8 0.6 0.4 0.3 1.0 0.8 0.8 2.5 0.9 1.2 -1.9 -1.6 0.9 1.8 -1.7 -1.8 0.7 0.7 1.3 1.6 -1.2 0.5 1.5 1.2 1.2 1.4 1.1 -2.2
HbA1C 0.7 0.7 2.8 0.9 0.8 0.7 0.9 0.8 0.5 1.4 -0.1 0.8 0.7 0.6 0.5 0.7 0.3 0.0 -0.8 0.3 0.7 -0.7 -1.7 0.8 0.8 1.3 0.7 -1.0 1.4 0.7 1.1 1.0 0.8 1.0 -0.7
HDL Cholesterol 0.7 1.1 3.6 1.8 -1.5 -0.6 1.4 1.0 0.4 0.3 0.3 -0.4 -1.2 -0.9 1.4 0.6 1.9 -1.3 -1.0 1.6 1.3 -1.1 -1.2 0.8 0.0 0.4 0.9 -0.8 0.5 1.1 0.9 0.9 1.2 0.9 -0.8
LDL Cholesterol 17.7 28.1 141.6 -2.4 4.1 3.4 -7.4 -6.6 -0.4 -1.1 0.2 -0.1 3.6 3.5 -11.9 -1.1 -2.8 9.9 7.0 -4.2 -6.3 7.0 6.0 0.2 2.6 -5.3 -6.5 4.6 -2.4 -5.7 -4.5 -4.9 -5.3 -4.3 8.5
Lupus 0.8 1.2 2.9 0.5 0.5 0.7 0.8 0.8 0.9 1.1 1.1 1.2 0.6 0.6 0.6 1.1 0.8 -0.4 -1.2 1.6 1.4 -1.5 -0.8 0.7 0.7 1.3 1.5 -1.5 1.3 1.5 1.4 1.7 0.9 1.6 -0.7
Neuroticism (2016) 0.2 0.2 2.2 1.5 -0.8 -0.6 1.1 0.2 -0.6 0.6 -0.5 -0.5 -0.7 -0.0 0.2 -0.1 0.4 0.1 -0.2 0.2 0.0 -0.2 -0.5 0.3 -0.4 0.0 0.1 -0.0 -0.2 0.2 0.0 -0.0 0.4 -0.1 -0.3
Primary Biliary Cirrhosis 1.6 2.3 7.2 -2.4 -1.2 -1.4 -1.1 -1.3 -1.5 -1.9 -1.1 -1.3 -1.4 -1.7 -0.8 -1.5 -1.1 -1.1 1.1 -1.1 -1.2 1.1 1.6 -0.9 -1.4 -2.2 -1.0 2.0 -2.7 -1.2 -1.8 -1.9 -1.3 -2.1 0.4
Rheumatoid Arthritis 0.3 0.4 2.4 1.4 -0.1 0.3 -0.5 -0.0 0.6 0.5 1.1 -0.1 0.1 0.6 -0.7 0.7 1.1 1.6 0.1 0.7 0.3 0.2 -0.3 1.0 0.7 -0.1 -0.2 -0.0 0.4 -0.0 0.1 -0.0 0.5 0.0 0.4
Schizophrenia (2014) 0.1 0.2 0.8 -0.3 0.9 0.6 0.4 0.1 0.1 0.1 -0.0 0.6 0.8 0.2 0.5 0.1 -0.5 0.8 -0.1 -0.3 -0.1 -0.2 -0.1 -0.1 0.3 0.5 0.1 -0.3 0.8 -0.0 0.2 0.4 -0.2 0.4 -0.4
Triglycerides 0.4 0.6 3.6 -0.1 1.9 1.4 0.1 -0.2 -0.1 -0.6 -0.6 1.2 1.8 1.1 0.2 -0.0 -1.1 1.5 0.2 -1.0 0.0 0.0 0.1 0.1 0.6 0.8 -0.0 -0.6 1.1 -0.1 0.4 0.6 -0.7 0.8 0.1
Type 2 Diabetes (T2D) (2012) 2.2 2.6 8.7 -1.8 -1.8 -1.9 -0.1 -1.2 -2.2 -1.6 -1.5 -1.2 -1.9 -2.4 -0.2 -1.9 -2.1 -3.0 0.5 -1.0 -1.6 0.5 1.4 -2.0 -2.4 -1.4 -0.3 1.5 -2.2 -0.7 -1.2 -1.3 -1.5 -1.5 0.3
Ulcerative Colitis 0.9 1.3 3.0 0.5 -1.4 -1.2 -1.4 -1.3 -1.1 -1.0 -1.7 -1.1 -1.4 -1.7 -1.7 -0.9 -0.3 -1.3 1.0 -0.3 -0.9 1.0 0.5 -0.7 -0.9 -1.4 -0.7 1.3 -1.5 -1.0 -1.1 -1.1 -1.0 -1.3 0.6
Blood Eosinophil Count 0.6 4.9 8.0 2.1 2.5 2.5 2.4 2.2 2.8 1.8 1.5 2.8 2.6 2.1 1.9 2.3 1.5 1.0 -2.4 1.9 2.2 -2.5 -1.5 1.9 2.3 2.6 2.4 -2.4 2.2 2.1 2.2 2.4 2.0 2.5 -2.3
Blood Platelet Count 0.6 7.1 17.9 -1.5 -1.3 -1.7 -2.8 -2.6 -3.0 -1.5 -4.2 -2.4 -1.6 -1.1 -1.8 -2.7 -2.2 -2.9 3.0 -3.0 -2.3 3.2 2.8 -1.4 -1.7 -3.6 -3.4 3.1 -3.4 -2.6 -2.9 -3.2 -2.8 -3.1 3.1
Blood Red Count 1.4 13.3 22.7 3.0 1.8 2.9 3.1 4.1 4.6 3.9 3.1 3.3 2.4 4.0 3.2 4.0 4.8 -0.0 -4.1 4.5 4.5 -4.1 -3.7 4.3 3.5 3.0 3.9 -3.6 2.4 4.2 3.8 3.6 4.5 3.4 -3.6
Blood White Count 0.1 0.8 3.9 -1.1 1.1 0.4 1.4 0.3 0.2 -0.0 -0.6 0.7 0.6 1.2 1.6 -0.7 -1.3 -2.0 -0.2 -1.1 -0.1 -0.2 -0.3 -1.1 -0.2 -0.3 0.2 0.7 -1.6 -0.3 -0.8 -0.9 -0.2 -1.0 -0.8
Heel T-Score 0.9 7.3 16.1 2.2 0.4 0.8 3.4 3.6 2.4 1.2 2.4 2.0 0.8 0.9 4.0 2.1 2.1 -0.6 -3.6 3.0 3.9 -3.8 -2.9 0.8 1.0 2.9 3.8 -3.0 1.8 3.3 2.7 3.2 3.0 3.0 -4.0
BMI 3.3 19.3 43.0 1.9 4.2 4.0 4.9 5.7 4.1 3.7 4.1 5.1 4.2 3.3 6.2 3.9 2.7 0.6 -5.6 3.5 5.6 -5.7 -4.6 4.0 3.6 4.1 5.4 -4.0 1.9 4.9 3.9 4.1 4.7 3.9 -6.6
Height 0.1 1.4 5.3 0.4 -0.7 -1.1 0.2 -0.4 -1.9 -2.3 -2.0 -0.8 -0.7 -2.0 1.0 -1.3 -1.6 -1.2 0.4 -1.4 -0.8 0.4 0.2 -1.8 -1.4 1.3 -0.5 -0.6 2.0 -0.5 0.3 0.8 -1.1 0.9 -0.2
Waist Hip Ratio (WHR) 0.2 0.9 7.7 -0.1 -0.2 0.0 1.3 0.9 0.4 1.4 0.3 0.1 0.0 0.7 0.4 0.8 1.2 -2.8 -0.8 1.0 0.9 -0.8 -0.3 0.7 0.4 0.8 0.7 -1.1 1.3 1.0 1.1 1.1 0.9 1.2 -0.2
Systolic Blood Pressure 0.7 3.7 9.4 1.5 2.8 3.0 0.5 1.2 2.8 2.1 2.6 2.5 2.9 3.1 0.2 2.4 2.0 2.1 -1.0 1.5 1.4 -1.0 -1.5 2.8 3.0 1.1 0.8 -1.4 1.6 1.3 1.6 1.2 1.4 1.3 0.1
Smoking Status 0.4 0.9 4.5 -0.8 -0.8 -1.1 1.6 0.8 -0.9 -0.9 -0.5 -0.4 -0.8 -1.4 2.1 -0.7 -0.6 -1.9 -0.9 -0.5 0.4 -0.9 -0.3 0.0 -1.3 0.9 0.8 -0.4 0.1 0.5 0.4 0.3 0.4 0.2 -1.6
Allergy or Eczema 0.5 1.4 4.3 2.1 0.3 0.9 0.9 1.1 1.4 2.0 0.7 0.9 0.6 1.5 0.7 1.4 2.1 0.1 -1.0 1.7 1.7 -1.1 -0.4 0.9 1.4 0.4 1.1 -0.8 0.1 1.2 1.1 0.6 1.5 0.6 -0.7
Cardiovascular Disease 1.8 5.9 21.8 1.7 4.5 4.4 -0.5 -0.0 2.6 1.9 4.1 3.4 4.3 3.8 -2.2 2.9 1.6 4.7 -0.0 1.4 1.1 -0.2 -0.1 3.2 4.3 0.2 0.2 -0.7 0.9 0.5 1.0 0.7 0.4 0.8 0.9
Hypothyroidism (self reported) 0.5 1.2 2.7 0.1 1.5 1.6 0.7 1.0 1.4 1.4 0.7 1.6 1.6 1.4 0.8 1.3 1.2 -0.0 -1.1 1.2 1.1 -1.1 0.2 0.8 1.6 0.6 1.1 -0.9 0.2 1.1 1.1 0.9 1.1 0.9 -0.8
Respiratory disease 3.0 6.8 15.4 1.3 1.2 1.4 3.0 3.4 2.8 3.4 2.6 2.2 1.4 1.6 3.9 2.2 2.3 0.9 -3.3 2.5 3.1 -3.3 -3.0 2.5 1.7 2.8 3.3 -2.5 1.8 2.8 2.6 2.3 3.3 2.2 -3.4
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.9 -0.6 0.9 0.7 0.6 0.4 -0.3 0.2 -0.6 0.9 0.7 0.8 0.7 0.1 -0.5 -0.3 -0.6 0.2 0.3 -0.6 -0.6 0.2 0.2 0.6 0.6 -0.5 0.5 0.6 0.3 0.6 -0.0 0.7 -0.6
Lung FEV1/FVC ratio 0.0 0.2 1.5 -1.2 0.6 0.3 0.2 0.7 -0.4 0.8 0.6 0.3 0.4 0.1 -0.6 0.1 0.1 1.0 -0.4 -0.6 0.1 -0.1 -0.5 -0.1 0.3 0.2 -0.1 -0.2 0.1 0.3 0.1 -0.0 0.4 0.1 -0.5
Lung FVC 0.2 1.2 5.5 -0.3 -2.4 -1.8 -0.3 -1.2 -0.9 -0.3 -0.9 -1.7 -2.1 -0.3 -0.5 -0.9 -0.1 -0.7 0.8 0.2 -1.9 0.9 0.8 -0.5 -1.4 -0.9 -0.4 1.0 -0.5 -1.0 -0.9 -1.2 -0.2 -1.2 1.3
Neuroticism 1.0 2.5 6.5 0.5 -1.0 -0.5 2.3 2.2 0.5 1.8 1.1 0.2 -0.8 -0.1 2.3 0.8 1.8 -2.5 -2.3 1.7 1.7 -2.2 -1.5 1.4 -0.1 0.9 2.2 -1.1 -0.2 2.1 1.4 1.1 2.2 0.9 -2.4
Chronotype (morning person) 3.3 7.6 31.5 4.7 1.6 2.1 0.8 1.9 3.0 1.1 1.9 2.1 1.7 1.2 1.1 2.7 2.3 3.9 -1.9 2.5 2.6 -2.0 -2.7 3.2 2.3 4.3 2.0 -3.7 5.6 1.9 3.3 3.7 2.0 3.8 -1.1
Hair Pigment 0.2 4.8 11.8 -3.1 -0.3 -1.0 -2.3 -2.1 -1.7 -1.6 -1.8 -1.3 -0.9 -0.6 -1.7 -2.1 -2.4 -1.3 2.2 -2.6 -2.4 2.2 2.6 -1.7 -1.4 -3.0 -2.1 2.9 -3.4 -2.2 -2.7 -3.0 -2.2 -3.0 1.9
Tanning 0.2 3.0 5.9 1.8 0.4 0.9 1.4 1.8 2.2 2.2 0.6 1.0 0.7 1.9 1.8 1.9 2.4 0.7 -1.8 2.3 1.5 -1.6 -2.1 1.9 1.5 2.0 1.6 -1.9 2.3 1.6 2.0 1.7 2.3 1.8 -1.3
Hand grip strength (left) 0.2 0.5 3.1 1.4 0.1 0.2 0.5 0.1 1.1 -0.4 0.4 0.5 0.2 0.4 0.7 0.4 0.1 1.0 -0.4 0.8 0.2 -0.5 -0.3 0.0 0.2 1.4 0.5 -1.0 1.8 0.3 0.9 1.1 0.2 1.1 -0.1
Number of treatments/medications taken 0.6 1.2 4.3 0.6 2.1 2.0 -0.6 -0.1 1.1 1.0 2.1 1.5 2.0 1.5 -1.1 1.2 0.6 1.4 0.1 0.5 0.4 0.1 0.8 1.4 1.9 -0.5 -0.1 0.1 -0.4 0.1 0.0 -0.0 0.0 0.1 0.4
Average weekly spirits intake 0.1 0.1 0.5 -0.4 0.1 -0.1 0.2 0.2 -0.1 0.3 0.2 -0.1 -0.0 0.0 0.3 -0.0 -0.1 -0.5 -0.2 -0.2 0.2 -0.2 -0.0 -0.7 -0.2 0.7 0.2 -0.3 0.5 -0.0 0.4 0.2 0.1 0.2 -0.3
Sensitivity / hurt feelings 3.7 6.3 14.9 1.6 0.2 0.4 3.1 3.6 2.0 2.7 2.6 1.2 0.4 0.4 3.9 1.9 2.3 -0.1 -3.4 2.0 3.0 -3.2 -3.2 2.2 0.8 3.2 3.1 -2.6 2.0 2.6 2.7 2.3 3.5 2.2 -3.8
Frequency of depressed mood in last 2 weeks 0.3 0.5 2.9 -0.5 -0.5 -0.6 1.0 0.8 -0.4 0.3 0.0 -0.2 -0.7 -1.2 0.9 -0.2 -0.0 -1.3 -0.8 0.1 0.4 -0.7 -0.4 -0.4 -0.6 -0.2 0.5 0.3 -1.2 0.3 -0.3 -0.4 0.6 -0.6 -1.7
Hearing difficulty/problems: Yes 2.1 3.1 11.2 -1.9 -2.7 -2.6 -0.8 -0.9 -2.1 -1.3 -1.9 -2.1 -2.6 -2.4 0.1 -2.1 -1.1 -3.3 0.8 -1.0 -0.5 0.6 1.5 -0.8 -2.4 -1.9 -0.5 1.9 -2.8 -1.0 -1.6 -1.8 -0.9 -2.1 -0.2
Relative age of first facial hair 0.8 1.7 3.4 -0.0 -1.4 -1.2 -1.4 -1.5 -1.8 -1.3 -1.6 -1.4 -1.3 -1.5 -1.7 -1.0 -0.4 -1.1 1.4 -0.6 -1.0 1.3 1.5 -1.8 -0.8 -1.5 -1.4 1.3 -0.9 -1.3 -1.1 -1.2 -1.2 -1.2 1.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.5 -1.2 -0.4 -0.4 -1.2 -0.3 0.4 -0.0 0.1 -0.4 -0.5 -0.3 -1.0 -0.3 -0.1 0.1 0.3 0.0 -0.0 0.2 0.7 -0.0 -0.2 -0.5 -0.2 0.8 -0.8 -0.5 -0.6 -0.9 -0.1 -1.1 0.1
Ever used hormone-replacement therapy (HRT) 1.4 1.8 5.2 -0.9 -1.5 -1.4 -1.9 -1.4 -1.2 -2.0 -1.3 -1.6 -1.5 -1.3 -1.0 -1.3 -1.0 -0.8 1.4 -0.9 -0.9 1.3 1.6 -2.3 -1.4 -1.3 -1.2 1.1 -0.8 -1.1 -1.2 -1.0 -1.4 -1.0 1.2
Ever had hysterectomy (womb removed) 1.1 1.3 3.3 -0.5 -1.3 -1.2 -1.2 -1.2 -1.1 -0.6 -1.2 -1.2 -1.4 -1.8 -1.0 -1.1 -0.8 -0.2 1.1 -0.6 -1.2 1.0 1.4 -0.6 -1.3 -1.1 -1.0 1.4 -1.0 -1.4 -1.3 -1.3 -1.0 -1.4 0.9
Systolic blood pressure, automated reading 1.1 3.2 6.6 0.5 2.6 2.5 1.4 1.7 2.3 2.2 1.7 2.5 2.6 2.5 1.4 1.9 1.1 0.9 -1.7 1.4 1.9 -1.7 -1.3 2.1 2.2 1.5 1.5 -1.6 1.3 1.7 1.6 1.5 1.5 1.6 -1.0
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 3.0 -1.7 -0.2 -0.1 -0.1 -0.5 -0.5 0.0 -0.3 0.1 -0.2 -0.3 -0.5 -0.1 -0.3 -1.1 0.2 0.4 -0.0 -0.0 0.2 0.2 -0.2 -0.9 0.2 0.6 -1.1 0.1 -0.6 -0.2 -0.4 -0.4 -0.0
Angina 0.3 0.4 3.2 -0.6 0.8 0.7 -0.7 -0.8 0.2 0.1 0.5 0.4 0.7 0.4 -1.8 0.1 -0.2 1.6 0.6 -0.0 -0.8 0.4 0.6 0.5 0.5 -0.5 -0.3 0.4 -0.3 -0.5 -0.4 -0.3 -0.6 -0.3 0.8
Medication for hormone replacement therapy 0.4 0.4 1.9 -0.8 -1.4 -1.1 -0.9 -0.3 -0.6 -1.0 -0.9 -1.1 -1.4 -1.3 -0.2 -0.5 0.1 -1.0 0.3 0.0 0.3 0.2 0.1 -0.3 -0.8 0.1 -0.3 0.1 0.4 -0.5 -0.1 -0.0 -0.2 -0.1 -0.1
Vitamin and mineral supplements 0.5 0.6 1.3 -0.8 -0.1 -0.3 -1.1 -0.9 -0.9 -0.9 -0.2 -0.6 -0.2 -0.8 -0.8 -0.8 -0.8 -0.0 1.0 -1.1 -1.1 1.0 1.1 -1.1 -0.5 -0.4 -1.2 0.4 0.2 -0.9 -0.5 -0.3 -1.1 -0.1 1.0
Supplements: Zinc 0.6 0.6 2.1 1.1 -0.3 0.0 1.3 0.9 0.5 0.7 0.1 0.3 -0.3 0.6 0.9 0.6 1.0 -0.9 -1.0 1.0 1.0 -1.1 -1.3 0.7 0.2 0.5 1.0 -0.3 -0.0 0.5 0.4 0.2 1.2 0.1 -1.4
Medication: Co-codamol 0.2 0.2 0.6 0.1 0.3 0.0 0.1 -0.7 -0.1 -0.4 -0.1 -0.1 0.2 -0.3 -0.4 -0.3 -0.6 0.6 0.6 -0.7 -0.7 0.5 0.5 -0.2 -0.1 -0.3 -0.5 0.6 -0.5 -0.6 -0.3 -0.6 -0.7 -0.7 0.4
Medication: Metformin 1.0 1.4 4.2 -2.1 0.0 -0.5 -1.0 -1.1 -1.6 -1.3 -1.0 -0.4 -0.3 -0.7 -0.7 -1.3 -1.9 -0.5 1.0 -1.4 -1.4 0.9 1.3 -1.3 -1.1 -1.1 -1.0 1.3 -1.3 -1.2 -1.4 -1.2 -1.5 -1.1 0.6
Diabetes (father) 0.5 0.6 2.1 0.1 -0.8 -1.0 -0.7 -0.4 -1.4 -0.8 -1.3 -1.1 -0.9 -1.1 -0.2 -0.8 -0.6 0.8 0.6 -1.2 -0.5 0.8 0.3 -1.1 -0.9 0.4 -1.0 0.1 0.9 -0.8 -0.2 -0.1 -0.6 -0.1 0.0
Diabetes (mother) 0.6 0.8 2.4 -0.8 -0.8 -1.1 -0.1 -0.7 -1.6 -1.2 -0.9 -0.7 -1.1 -1.2 0.3 -1.2 -1.5 -1.0 0.4 -0.8 -0.9 0.3 0.8 -1.2 -1.4 -0.5 -0.3 0.9 -0.8 -0.7 -0.9 -0.7 -0.9 -0.9 -0.2
Severe depression (siblings) 0.1 0.1 0.4 0.6 -0.3 -0.1 0.4 -0.0 -0.1 0.3 0.0 -0.1 -0.3 -0.2 0.1 -0.0 0.2 -0.6 -0.0 0.2 -0.2 -0.0 0.3 -0.1 -0.1 -0.4 0.1 0.3 -0.6 -0.1 -0.3 -0.3 0.1 -0.4 -0.4
Pack years adult smoking proportion 5.7 8.7 15.7 -2.4 -2.4 -2.8 -4.0 -3.0 -2.5 -3.9 -3.2 -3.1 -2.9 -3.1 -2.9 -3.1 -2.9 -0.3 3.1 -2.8 -2.2 3.1 3.1 -3.0 -2.8 -2.9 -3.1 3.1 -2.6 -3.4 -3.2 -2.8 -3.3 -3.0 2.2
Impedance of leg (right) 9.2 44.5 72.9 -3.5 -4.4 -5.1 -7.5 -8.2 -6.6 -6.0 -6.0 -6.7 -5.0 -5.0 -8.5 -6.4 -6.0 -0.1 8.4 -6.9 -7.8 8.4 7.3 -6.8 -5.3 -6.7 -8.4 6.6 -4.5 -7.6 -6.7 -6.7 -7.9 -6.5 8.5
Leg fat-free mass (left) 2.7 14.3 27.8 2.7 3.2 3.2 4.5 4.5 3.5 2.6 3.2 4.2 3.4 2.5 5.3 3.3 2.3 0.4 -4.7 3.2 4.4 -4.8 -4.0 3.3 2.8 4.3 4.6 -4.0 3.1 4.1 3.8 4.1 3.9 4.0 -5.1
Trunk fat percentage 0.6 2.5 7.7 -1.8 0.7 -0.3 -1.5 -1.1 -1.6 -2.0 -0.8 -0.2 0.2 -1.4 -0.6 -1.7 -2.8 -1.1 1.2 -2.1 -0.7 1.1 1.7 -2.3 -1.1 -1.9 -1.2 2.0 -2.7 -1.4 -2.2 -1.7 -2.1 -1.8 -0.2
Hand grip strength (right) 0.1 0.4 2.2 1.5 -1.2 -0.9 0.1 -0.2 0.6 -0.5 -0.1 -0.7 -1.0 -0.3 0.1 -0.5 -0.2 0.9 0.1 0.2 -0.2 0.1 0.0 -0.2 -0.8 0.9 -0.1 -0.4 1.2 -0.4 0.2 0.3 -0.1 0.3 0.3
Townsend deprivation index at recruitment 1.2 1.7 5.0 0.9 -0.3 0.1 1.8 1.7 1.6 1.8 0.4 0.6 -0.1 0.9 1.7 0.7 1.2 -0.2 -1.8 1.6 1.5 -1.9 -1.7 2.2 0.2 1.2 1.9 -0.8 0.1 1.2 0.8 0.7 1.9 0.5 -1.8
Current tobacco smoking 2.0 3.2 9.4 -3.1 -1.1 -1.7 -1.3 -1.4 -1.6 -1.7 -2.2 -1.8 -1.4 -1.3 -0.7 -2.4 -2.4 -1.2 1.7 -2.6 -1.8 1.8 1.9 -1.9 -2.0 -1.3 -1.8 1.7 -1.5 -1.8 -1.9 -1.9 -1.8 -1.9 1.3
Average weekly fortified wine intake 1.8 2.1 3.7 1.1 1.9 1.8 1.2 1.4 1.3 1.3 1.6 1.9 1.9 1.0 1.7 1.6 1.0 -0.7 -1.5 1.4 1.5 -1.5 -1.1 0.8 1.6 1.5 1.5 -1.6 1.3 1.6 1.4 1.8 1.2 1.7 -1.2
Maternal smoking around birth 0.6 0.9 1.9 -0.4 -1.3 -1.3 -0.7 -0.7 -1.3 -0.1 -1.2 -1.3 -1.4 -1.2 -1.0 -1.1 -0.9 -0.2 0.8 -0.7 -1.2 0.7 0.5 -1.3 -1.4 -0.6 -0.8 0.8 -0.4 -0.9 -0.9 -0.8 -0.7 -0.7 0.6
Fed-up feelings 0.8 1.4 6.0 -0.9 -2.4 -2.3 0.6 0.5 -1.0 -0.4 -1.4 -1.8 -2.4 -1.8 0.9 -1.4 -0.5 -2.0 -0.3 -0.6 -0.1 -0.3 -0.1 -0.6 -2.2 -0.3 0.1 0.6 -1.2 -0.2 -0.5 -0.7 0.3 -0.9 -1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 2.0 -0.4 1.2 0.9 0.9 0.7 -0.0 0.3 1.1 1.1 1.0 0.2 0.8 0.4 -0.1 -1.0 -0.8 0.1 0.4 -0.8 -0.4 0.5 0.6 0.1 0.6 -0.1 -0.7 0.7 0.1 0.2 0.4 -0.0 -1.4
Relative age voice broke 1.5 2.3 3.9 0.7 0.6 1.0 1.3 1.7 1.2 1.3 1.4 1.3 0.9 1.5 1.5 1.6 1.9 -0.6 -1.9 1.8 1.9 -1.8 -1.6 0.8 1.4 1.6 1.6 -1.7 1.6 1.7 2.0 1.7 1.9 1.7 -1.6
Taking other prescription medications 0.6 0.9 2.4 0.1 0.5 0.6 1.0 1.6 1.0 0.8 0.8 0.9 0.7 0.6 1.3 0.6 0.8 -0.3 -1.4 0.8 1.4 -1.3 -1.1 1.4 0.7 0.7 1.2 -0.8 -0.0 1.3 0.9 0.7 1.3 0.8 -1.5
Age when periods started (menarche) 0.9 2.1 4.1 0.0 -1.8 -2.0 -1.2 -1.4 -1.5 -1.7 -1.1 -1.9 -1.9 -1.7 -1.3 -1.9 -1.5 -0.2 1.5 -1.6 -1.1 1.5 0.6 -2.0 -1.9 -1.0 -1.5 1.0 -0.7 -1.2 -1.1 -1.0 -1.7 -0.9 1.6
Bilateral oophorectomy (both ovaries removed) 0.2 0.3 1.6 -0.7 -0.6 -0.6 -1.2 -0.4 -0.4 -0.0 -0.4 -0.7 -0.6 -0.6 -0.5 -0.3 -0.2 0.8 0.5 -0.3 -0.2 0.5 0.3 -0.2 -0.5 0.0 -0.5 0.2 0.2 -0.5 -0.2 -0.2 -0.3 -0.3 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.5 2.0 0.4 0.7 0.9 0.5 0.4 1.4 0.5 1.0 1.2 0.8 0.8 0.7 0.8 0.4 0.1 -0.7 1.1 0.7 -0.9 -0.2 0.4 0.8 0.5 1.1 -0.5 0.4 0.6 0.5 0.7 0.5 0.6 -0.4
Tinnitus: Yes, but not now, but have in the past 1.6 1.7 3.3 -0.0 -1.7 -1.7 -1.1 -1.0 -1.7 -1.1 -1.5 -1.4 -1.8 -1.8 -1.0 -1.7 -1.3 0.3 0.8 -0.8 -1.0 0.7 0.9 -0.8 -1.8 -1.2 -0.7 1.6 -1.8 -1.2 -1.5 -1.4 -1.1 -1.6 -0.1
Qualifications: CSEs or equivalent 0.5 0.7 7.5 1.1 1.3 0.8 -0.6 -0.6 0.0 -0.1 -0.2 0.3 1.0 0.7 -0.8 -0.0 -0.6 2.7 0.8 -1.0 -0.8 0.8 -0.3 0.8 0.6 0.5 -0.8 -0.3 1.2 -0.6 0.1 0.1 -0.6 0.4 1.0
Serious illness, injury or assault to yourself 1.5 1.8 4.7 -0.4 0.7 0.2 -1.3 -1.7 -1.0 -1.0 -1.1 -0.3 0.4 0.4 -1.7 -1.1 -1.7 1.6 1.7 -1.9 -2.2 1.7 1.7 0.0 -0.3 -1.1 -1.7 1.3 -0.8 -1.7 -1.4 -1.5 -1.7 -1.3 2.0
High blood pressure 0.7 2.0 5.4 0.2 2.3 2.3 0.8 0.9 1.4 1.8 2.2 2.3 2.3 2.0 0.9 1.8 1.2 -0.7 -1.1 1.5 1.9 -1.3 -0.4 1.5 2.2 -0.2 1.2 -0.3 -0.7 1.2 0.7 0.6 0.9 0.4 -1.0
Hayfever, allergic rhinitis or eczema 0.8 1.7 4.2 1.7 1.3 1.7 0.9 1.0 1.8 1.8 0.9 1.4 1.5 1.9 0.8 1.8 2.1 0.4 -0.9 1.5 1.5 -0.8 -0.5 1.4 2.0 0.5 0.9 -0.9 0.3 1.2 1.2 0.8 1.4 0.8 -0.5
Multivitamins +/- minerals 3.0 3.8 7.7 2.5 0.6 1.2 1.6 2.2 2.7 2.0 1.3 1.4 0.9 1.4 1.5 2.3 2.7 1.6 -2.1 2.4 2.8 -2.1 -2.6 2.4 1.8 1.7 2.1 -1.6 1.3 1.9 1.8 1.4 2.7 1.2 -2.0
Stomach or abdominal pain in last month 3.9 4.9 9.9 -1.4 -2.5 -2.6 -2.0 -2.0 -2.4 -2.2 -3.1 -2.8 -2.7 -2.7 -1.8 -2.6 -1.9 -0.9 2.2 -2.3 -2.2 2.4 1.7 -2.1 -2.5 -1.7 -2.4 2.1 -1.5 -2.4 -2.1 -2.2 -2.0 -2.2 1.6
Supplements: Glucosamine 1.9 2.4 5.8 0.6 -2.1 -1.5 1.7 2.2 0.7 -0.3 0.4 -0.7 -1.6 -0.9 2.1 0.3 1.6 -1.4 -2.0 1.5 2.4 -2.0 -1.8 1.2 -0.8 1.5 1.9 -1.4 0.8 1.8 1.5 1.4 2.1 1.2 -2.4
Diverticular disease/diverticulitis (self-reported) 1.8 2.1 6.2 1.9 0.3 0.6 1.3 1.6 1.0 1.3 1.4 0.9 0.5 0.4 1.7 1.2 1.5 0.8 -1.6 1.4 1.3 -1.6 -1.0 1.4 0.9 2.1 1.4 -2.0 2.5 1.6 2.0 2.0 1.6 2.1 -1.1
Medication: Atenolol 0.3 0.4 1.6 0.3 1.3 1.2 -0.6 -0.4 0.5 0.3 1.1 0.9 1.2 0.8 -1.0 0.6 0.1 1.0 0.3 0.1 -0.4 0.3 0.6 0.3 0.9 -0.2 -0.3 0.1 -0.0 -0.2 -0.1 0.0 -0.3 0.0 0.5
Medication: Levothyroxine sodium 0.4 0.6 3.1 -1.0 1.8 1.7 -0.1 0.3 0.5 0.4 0.3 1.3 1.8 1.2 0.5 0.8 0.5 -0.1 -0.2 0.3 0.8 -0.3 0.4 0.5 1.6 0.1 0.1 -0.4 0.2 0.3 0.5 0.4 0.2 0.5 -0.2
Sitting height 0.2 1.2 6.9 2.0 1.4 1.1 0.7 0.2 0.1 -1.0 0.5 1.2 1.4 1.0 0.7 0.5 -0.5 1.3 -0.3 -0.2 0.3 -0.5 -0.2 -0.5 0.6 2.0 0.3 -1.6 2.6 0.5 1.3 1.7 -0.3 1.8 -0.3
Chronic bronchitis/emphysema (father) 0.2 0.3 1.1 -0.3 0.5 0.7 0.6 0.5 1.1 0.7 0.7 0.5 0.5 0.1 0.4 0.8 0.8 0.3 -0.5 0.8 0.2 -0.4 0.6 0.5 0.7 0.1 0.4 -0.1 -0.0 0.2 0.1 0.1 0.7 0.1 -0.5
High blood pressure (mother) 2.8 3.9 8.3 1.3 2.1 2.1 1.6 1.9 2.9 2.5 1.5 2.4 2.2 2.4 1.4 1.9 1.4 1.4 -1.9 1.7 1.8 -2.1 -1.9 2.5 2.0 2.1 2.2 -2.0 1.6 2.0 2.0 1.8 2.0 1.8 -1.4
Body mass index (BMI) 1.8 7.7 17.1 0.9 3.1 2.9 2.8 3.5 2.9 2.1 3.1 3.6 3.1 2.2 3.9 2.4 1.4 0.6 -3.5 2.2 3.7 -3.5 -2.4 2.8 2.5 2.1 3.4 -2.2 0.6 3.0 2.1 2.4 2.7 2.2 -4.1
Impedance of leg (left) 10.2 49.6 77.4 -3.9 -4.5 -5.3 -7.9 -8.6 -7.1 -6.4 -6.2 -6.9 -5.2 -5.3 -8.8 -6.8 -6.5 -0.5 8.7 -7.3 -8.3 8.8 7.6 -7.6 -5.6 -7.2 -8.6 7.1 -5.0 -8.0 -7.2 -7.1 -8.4 -7.0 8.7
Leg predicted mass (left) 2.7 14.4 28.2 2.7 3.2 3.2 4.5 4.6 3.5 2.6 3.2 4.2 3.5 2.5 5.3 3.3 2.3 0.4 -4.7 3.2 4.4 -4.8 -4.0 3.4 2.8 4.4 4.6 -4.0 3.2 4.1 3.8 4.2 3.9 4.0 -5.1
Trunk fat mass 0.1 0.6 2.5 -0.6 1.4 0.7 0.0 0.3 -0.3 -1.0 0.2 1.1 1.1 -0.5 1.0 -0.4 -1.6 -0.8 -0.4 -0.7 0.7 -0.5 0.3 -0.9 -0.1 -0.3 0.4 0.5 -1.2 0.1 -0.7 -0.1 -0.7 -0.3 -1.6
Waist circumference 1.0 3.5 10.0 -0.2 2.1 1.9 2.0 2.4 1.6 1.0 2.0 2.5 2.1 0.9 2.9 1.5 0.6 -1.1 -2.5 1.5 2.8 -2.6 -1.5 1.4 1.4 1.3 2.5 -1.4 0.1 2.2 1.3 1.7 1.6 1.6 -3.2
Number of incorrect matches in round 0.1 0.2 0.8 0.2 0.3 0.2 -0.1 -0.5 0.1 0.3 -0.1 0.1 0.3 -0.2 -0.5 -0.3 -0.6 -0.9 0.4 -0.3 -0.7 0.3 0.1 0.1 -0.2 -0.6 -0.3 0.6 -0.8 -0.5 -0.6 -0.7 -0.5 -0.7 0.6
Past tobacco smoking 0.6 1.1 3.4 -0.6 -0.4 -0.3 -1.8 -1.2 -0.3 -0.4 -0.6 -0.9 -0.4 0.2 -1.7 -0.9 -0.6 1.2 1.4 -1.0 -1.1 1.6 0.7 -1.2 -0.3 -1.2 -1.6 1.0 -0.7 -1.2 -1.1 -1.1 -1.2 -0.9 1.9
Alcohol usually taken with meals 0.2 0.3 1.7 0.7 0.8 0.9 0.7 0.5 -0.0 -0.0 1.3 0.8 0.8 -0.0 0.1 0.8 0.6 0.1 -0.4 0.3 0.8 -0.4 -0.8 0.4 0.9 0.0 0.2 -0.3 -0.1 0.6 0.4 0.5 0.2 0.5 -0.8
Nervous feelings 1.6 3.1 5.7 2.4 0.9 1.0 2.4 2.1 0.7 1.9 2.1 1.2 1.0 0.2 2.0 1.5 1.7 0.4 -2.0 1.3 1.7 -1.8 -2.2 1.7 1.3 2.1 1.5 -2.1 2.1 2.0 2.1 2.1 1.9 2.1 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.6 -0.0 -0.1 -0.1 -0.2 -0.2 -0.2 0.3 -0.0 -0.2 -0.1 0.1 -0.6 -0.3 -0.1 -0.5 0.3 -0.4 -0.4 0.3 0.7 -0.1 -0.1 -0.5 -0.5 0.5 -0.5 -0.4 -0.3 -0.7 -0.2 -0.6 0.4
Hearing difficulty/problems with background noise 2.2 3.5 8.6 -2.5 -2.2 -2.5 -0.6 -1.0 -2.4 -1.8 -1.2 -1.9 -2.3 -2.5 0.1 -2.6 -2.2 -2.9 0.9 -1.7 -1.1 0.7 1.7 -1.4 -2.8 -1.9 -0.5 2.0 -2.9 -1.0 -1.9 -1.9 -1.5 -2.1 0.0
Hair/balding pattern: Pattern 2 0.7 0.9 2.2 1.5 0.5 0.6 1.1 1.0 0.9 0.5 0.6 0.8 0.6 0.7 0.9 0.9 0.9 -0.3 -1.0 1.1 0.8 -1.0 -0.8 1.2 0.6 1.1 1.0 -1.3 1.2 1.2 1.2 1.3 1.1 1.2 -0.9
Had menopause 0.9 1.1 5.2 -1.0 -1.8 -1.6 -0.9 -0.7 -1.4 -1.4 -1.3 -1.3 -1.8 -2.3 0.1 -1.1 -0.5 -1.4 0.6 -0.3 -0.1 0.5 0.3 -1.2 -1.5 -0.6 -0.6 0.6 -0.4 -0.5 -0.6 -0.4 -0.8 -0.5 0.2
Had other major operations 0.1 0.2 1.3 0.3 0.6 0.4 0.5 0.4 0.2 -0.0 1.1 0.5 0.4 0.1 0.8 0.0 -0.3 -0.1 -0.4 -0.1 0.2 -0.5 -0.3 0.1 0.1 0.4 0.4 -0.1 -0.1 0.2 0.1 0.1 0.3 -0.0 -0.9
Forced vital capacity (FVC) 0.2 0.6 2.5 0.7 -1.3 -0.9 0.1 -1.0 -0.8 -0.6 -0.7 -1.1 -1.1 0.2 -1.0 -0.6 0.1 -0.7 0.7 -0.1 -1.6 0.9 0.9 -0.5 -0.6 -0.2 -0.6 0.4 0.7 -0.8 -0.2 -0.6 -0.2 -0.5 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.7 0.4 -0.5 -0.2 -0.0 0.1 0.6 0.0 -0.2 0.3 -0.4 -0.1 0.2 0.0 -0.1 -0.4 -0.5 0.8 0.4 -0.7 -0.1 -0.1 -0.2 0.1 0.6 0.0 -0.1 0.1 -0.1 0.2 0.1 0.1 -0.5
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 1.9 -0.2 -0.0 -0.3 -0.4 -0.1 0.4 -0.4 -0.7 -0.3 -0.3 -0.2 -0.3 -0.4 -0.7 1.4 0.3 -0.7 -0.3 0.2 0.1 -0.6 -0.4 0.6 -0.1 0.0 0.5 -0.6 -0.1 -0.3 -0.1 -0.2 0.1
Qualifications: None of the above 8.2 17.5 29.3 -5.4 -1.9 -2.8 -4.6 -4.9 -4.1 -3.7 -3.9 -3.4 -2.4 -2.9 -3.9 -4.1 -4.5 -1.6 4.8 -4.4 -4.7 4.8 4.5 -4.3 -3.3 -4.7 -4.8 4.6 -4.0 -4.5 -4.6 -4.4 -5.0 -4.4 4.6
Financial difficulties in last 2 years 1.1 1.4 4.0 -1.1 0.8 1.0 1.4 1.5 1.8 1.1 1.5 1.1 0.9 1.5 0.8 1.1 1.2 0.3 -1.5 1.1 1.3 -1.4 -0.5 2.0 1.0 0.9 1.5 -0.7 0.2 1.1 0.9 0.5 1.7 0.5 -1.5
Mouth/teeth dental problems 0.3 0.4 1.6 1.3 -1.2 -0.9 0.5 0.8 0.3 0.4 0.2 -0.7 -1.1 -0.4 1.0 0.1 1.0 0.3 -0.6 0.5 0.2 -0.3 -0.7 -0.2 -0.4 0.5 0.4 -0.3 0.2 0.2 0.3 0.1 1.0 0.1 -0.8
Heart attack 0.7 0.9 4.0 0.1 1.7 1.6 -1.0 -0.5 1.2 0.2 1.4 1.0 1.6 1.4 -1.4 0.8 0.3 2.0 0.5 0.1 0.0 0.5 0.5 0.4 1.5 -0.7 -0.4 0.4 -0.5 -0.4 -0.3 -0.4 -0.3 -0.3 0.8
Allergy 0.7 1.5 3.6 -1.0 -1.3 -1.5 -1.3 -1.2 -1.8 -1.9 -1.3 -1.3 -1.3 -1.7 -1.4 -1.4 -1.5 -0.9 1.0 -1.2 -1.1 1.0 0.6 -1.3 -1.7 -0.6 -1.1 0.8 -0.2 -1.2 -1.0 -0.7 -1.4 -0.7 0.8
Pain all over the body in last month 0.4 0.5 1.6 -0.1 0.4 0.3 0.1 0.7 0.6 1.3 0.3 0.6 0.4 0.3 0.4 0.4 0.0 0.5 -0.7 0.5 0.8 -0.9 -0.8 0.7 0.1 1.0 1.0 -1.0 1.0 0.9 0.8 0.9 0.6 0.9 -0.3
Diabetes (self-reported) 0.4 0.6 3.3 -1.6 1.8 1.3 0.1 -0.2 -0.5 -0.2 -0.1 1.3 1.5 1.3 0.2 -0.0 -1.2 0.3 0.1 -0.6 -0.1 0.1 0.2 0.1 0.6 -0.4 -0.1 0.4 -0.9 -0.1 -0.5 -0.2 -0.7 -0.3 -0.1
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 4.7 2.2 -0.7 -0.0 0.2 0.5 0.0 0.3 -0.1 -0.1 -0.3 -0.3 0.6 0.6 1.6 -0.8 -0.4 0.8 0.5 -0.2 0.0 0.8 0.5 -0.1 0.0 -0.4 -0.1 0.6 0.5 0.4 0.8 0.4 -0.4
Medication: Ramipril 2.0 2.6 10.8 0.8 2.9 3.2 -0.8 -0.1 2.1 1.2 1.9 2.0 3.0 2.3 -0.8 2.0 1.6 2.6 0.4 0.9 0.7 0.4 -0.6 2.1 3.3 -0.4 -0.4 -0.4 0.5 0.4 0.5 0.5 0.3 0.6 1.1
Medication: Simvastatin 4.0 5.9 27.6 0.4 4.5 4.4 -1.8 -1.4 2.4 1.4 2.9 2.9 4.4 4.1 -3.7 2.0 0.5 5.2 1.3 0.3 -0.3 1.2 0.9 1.9 3.9 -0.5 -1.0 -0.1 1.1 -0.5 0.2 0.2 -0.9 0.5 2.9
Fluid intelligence score 8.3 17.2 26.3 2.0 3.1 3.5 5.1 5.0 3.9 4.5 4.6 4.3 3.4 3.8 4.5 4.2 3.7 0.1 -5.0 4.1 4.1 -4.9 -4.2 3.9 3.6 4.2 5.0 -4.3 3.1 4.9 4.2 4.2 4.8 4.2 -4.4
Illnesses of siblings 0.4 0.6 1.7 1.0 -1.0 -0.5 0.8 0.9 0.6 0.0 -0.2 -0.4 -0.7 0.5 0.6 0.2 1.1 -0.1 -0.8 0.6 0.4 -0.6 -1.1 0.5 -0.1 1.2 0.4 -1.0 1.3 0.3 0.9 0.7 1.1 0.8 -0.8
Neuroticism score 1.0 2.1 5.2 1.0 -0.4 -0.1 2.1 2.2 0.9 2.1 1.2 0.4 -0.3 0.2 2.3 1.0 1.6 -1.0 -2.1 1.3 1.7 -2.0 -1.7 1.1 0.2 1.5 1.8 -1.3 0.5 1.7 1.5 1.1 2.2 1.0 -2.3
Weight 1.0 4.7 12.7 1.0 2.6 2.2 2.5 2.7 1.9 0.9 2.1 3.0 2.6 1.3 3.6 1.6 0.4 -0.0 -2.8 1.4 2.8 -2.9 -1.8 1.5 1.6 2.2 2.7 -1.9 1.0 2.4 1.7 2.2 1.7 2.1 -3.5
Impedance of arm (right) 7.3 34.2 47.9 -4.2 -3.3 -4.5 -6.1 -6.5 -6.6 -5.1 -6.0 -5.6 -4.2 -4.7 -6.9 -6.1 -6.3 -2.6 6.8 -6.8 -6.9 6.9 5.7 -6.8 -5.1 -5.6 -6.8 6.0 -4.4 -6.7 -6.2 -6.0 -6.8 -5.8 5.9
Arm fat percentage (right) 0.2 0.7 3.3 -1.1 1.4 0.6 0.1 0.6 -0.1 -0.5 -0.0 1.0 1.0 -0.3 0.9 -0.5 -1.6 -1.2 -0.5 -0.8 0.8 -0.6 0.2 -0.4 -0.2 -0.5 0.5 0.7 -1.6 0.1 -0.8 -0.4 -0.4 -0.5 -1.8
Trunk fat-free mass 2.7 15.4 29.8 3.1 2.6 2.9 4.7 4.5 3.7 2.7 3.0 3.9 3.1 2.6 5.5 3.5 3.0 0.8 -4.8 3.7 4.5 -4.8 -4.1 3.5 2.9 4.7 4.6 -4.4 3.9 4.3 4.3 4.5 4.1 4.4 -4.7
Hip circumference 0.2 0.7 4.2 -0.2 1.4 0.9 0.5 1.0 0.2 -0.9 0.6 1.4 1.3 -0.1 1.9 -0.1 -1.0 -0.1 -1.0 -0.4 1.2 -1.1 -0.4 0.2 0.2 0.2 0.9 -0.0 -0.9 0.7 -0.1 0.3 0.1 0.1 -2.0
Time employed in main current job 0.9 1.0 2.5 -0.4 -0.6 -0.6 -0.9 -1.4 -0.7 -0.8 0.3 -0.9 -0.7 -1.0 -1.5 -0.9 -0.7 -0.5 1.3 -0.8 -1.4 1.2 0.6 -0.1 -0.7 -1.6 -1.3 1.1 -1.1 -0.9 -1.1 -1.1 -1.2 -1.0 1.6
Alcohol intake versus 10 years previously 1.5 2.2 6.2 0.8 -1.8 -1.1 1.5 2.1 1.1 0.7 0.3 -0.5 -1.4 -0.3 1.9 0.9 2.2 -1.9 -1.9 1.9 2.5 -1.9 -2.0 1.1 -0.2 1.0 1.9 -0.9 -0.1 1.6 1.2 0.8 2.4 0.5 -2.2
Father’s age at death 3.3 4.5 12.5 0.9 0.0 0.6 3.0 2.6 1.2 1.2 1.0 1.4 0.3 -0.1 3.5 1.9 2.3 -0.7 -2.9 2.5 2.5 -3.0 -2.2 1.5 0.9 2.3 2.8 -2.2 1.5 2.5 2.4 2.4 2.6 2.2 -3.3
Worrier / anxious feelings 0.5 0.9 4.5 0.7 -0.5 -0.6 1.6 1.5 0.5 0.7 0.9 -0.2 -0.5 -0.5 2.1 0.2 0.4 -0.2 -1.2 0.1 1.0 -1.0 -1.2 -0.0 -0.4 1.3 0.9 -0.9 0.6 0.8 1.0 0.7 1.1 0.6 -1.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 2.4 1.2 -0.7 -0.4 1.1 0.9 0.2 1.6 0.8 -0.1 -0.6 -0.4 0.4 0.7 1.2 -1.1 -1.0 1.0 0.7 -0.9 -0.9 0.5 0.1 0.3 0.9 -0.3 -0.2 0.6 0.4 0.2 1.2 0.2 -1.3
Falls in the last year 4.0 5.4 8.5 -1.2 -1.1 -1.6 -2.3 -2.7 -2.2 -2.5 -2.2 -1.7 -1.5 -1.9 -1.9 -2.4 -2.9 -1.3 2.5 -2.3 -2.2 2.3 2.9 -2.2 -2.0 -2.6 -2.2 2.9 -2.7 -2.7 -2.9 -2.8 -2.9 -2.9 1.9
Hair/balding pattern: Pattern 3 1.0 1.5 3.7 1.5 -0.8 -0.1 0.1 1.2 1.4 0.9 0.6 0.1 -0.3 0.7 0.5 1.1 1.9 1.6 -1.1 1.8 1.9 -1.2 -1.1 1.3 0.5 1.6 1.3 -1.4 1.9 1.0 1.4 1.4 1.5 1.3 -0.9
Number of live births 3.8 5.4 11.3 -2.9 0.2 -0.6 -2.8 -3.1 -1.4 -2.6 -2.1 -1.0 -0.3 -0.9 -1.8 -2.1 -3.3 0.1 2.8 -2.4 -2.7 2.6 3.4 -3.3 -1.4 -2.3 -2.4 2.4 -1.8 -2.5 -2.4 -2.2 -3.2 -2.1 3.0
Forced expiratory volume in 1-second (FEV1) 0.1 0.5 2.2 0.5 -0.9 -0.7 -0.0 -0.9 -0.9 -0.5 -0.6 -0.9 -0.8 0.0 -1.2 -0.6 -0.1 -0.3 0.7 -0.3 -1.5 0.9 0.7 -0.4 -0.5 -0.3 -0.8 0.5 0.4 -0.8 -0.3 -0.6 -0.3 -0.5 1.2
Pulse rate 0.6 1.1 6.2 1.8 0.7 1.0 -0.1 0.5 1.5 1.1 0.4 0.5 0.9 1.8 -0.2 1.1 1.5 2.5 -0.1 0.7 0.8 -0.0 -0.9 1.7 1.4 0.9 -0.1 -0.9 1.5 0.1 0.8 0.6 0.8 0.7 0.1
Happiness 0.2 0.2 1.6 0.8 0.1 0.2 0.5 0.7 0.6 0.2 0.3 0.3 0.2 0.1 0.2 0.3 0.6 -1.3 -0.6 0.3 0.3 -0.5 -0.6 0.6 0.3 0.3 0.4 -0.1 -0.2 0.3 0.2 0.1 0.7 -0.1 -1.0
Noisy workplace 9.5 11.7 17.4 -2.1 -3.4 -3.5 -4.2 -3.6 -2.7 -3.0 -4.2 -3.7 -3.6 -3.1 -3.0 -3.5 -2.6 -2.1 3.5 -2.6 -2.9 3.5 3.8 -3.4 -3.3 -3.9 -3.4 4.0 -3.6 -3.7 -3.8 -3.9 -3.3 -4.1 2.9
Qualifications: A levels/AS levels or equivalent 2.7 6.0 12.7 3.6 1.0 1.6 3.2 2.6 2.4 2.4 2.3 1.9 1.3 2.0 2.1 2.5 2.8 1.6 -2.6 2.6 2.1 -2.6 -2.9 2.9 2.0 2.7 2.6 -2.6 2.5 2.4 2.5 2.4 3.0 2.5 -2.1
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 3.5 1.0 -0.1 0.6 -0.1 0.7 1.5 1.1 1.2 0.6 0.2 1.2 0.1 1.2 1.9 0.2 -0.8 1.9 1.4 -1.0 -0.2 1.3 1.1 0.0 1.0 -0.1 -0.2 0.6 0.4 0.1 1.4 -0.1 -0.9
Mouth/teeth dental problems: Dentures 0.2 0.3 1.1 -0.4 1.0 1.0 0.2 -0.2 0.5 0.1 0.0 1.0 1.1 0.8 -0.1 0.6 0.1 -0.8 -0.0 0.6 0.3 -0.3 -0.0 1.0 0.8 -0.5 0.3 -0.1 -0.5 0.6 0.1 0.4 -0.3 0.4 0.2
Asthma 2.1 4.2 8.3 1.1 0.8 1.1 2.1 2.6 2.4 2.3 2.5 1.5 0.9 1.0 2.6 1.9 2.2 0.7 -2.4 2.2 2.5 -2.5 -2.1 2.0 1.4 2.2 2.5 -2.0 1.6 2.2 2.0 2.1 2.6 1.9 -2.9
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 2.7 -0.3 -1.6 -1.6 -0.2 -0.2 -0.5 0.1 -1.2 -1.4 -1.6 -1.5 -0.2 -1.1 -0.6 -1.4 0.3 -0.7 -0.4 0.3 0.5 -0.5 -1.6 -0.4 -0.3 0.8 -0.8 -0.7 -0.8 -1.0 -0.1 -1.0 -0.2
Medication: Cholesterol lowering 4.1 6.3 39.7 1.6 3.8 3.9 -2.5 -1.8 2.1 1.0 3.1 2.2 3.8 3.6 -4.9 2.0 1.0 6.3 1.8 0.4 -0.7 1.7 1.5 2.3 3.7 -1.0 -1.4 0.3 0.9 -0.9 -0.2 -0.3 -0.9 0.1 3.4
Depression (self-reported) 0.3 0.4 1.3 0.0 -0.0 -0.3 0.4 -0.5 -1.1 -0.9 -0.3 -0.2 -0.2 -0.9 0.2 -0.8 -1.1 -0.9 0.4 -0.9 -0.8 0.4 0.2 -0.9 -0.6 -0.6 -0.6 0.7 -0.7 -0.5 -0.7 -0.6 -0.8 -0.6 -0.1
Medication: Lansoprazole 2.4 2.7 8.9 -0.6 -1.5 -1.7 -1.8 -1.8 -2.1 -1.4 -3.0 -1.7 -1.7 -2.0 -1.5 -1.8 -1.7 -0.8 1.7 -1.3 -1.7 1.6 1.6 -1.2 -1.8 -1.1 -1.6 1.6 -0.9 -2.1 -1.7 -1.5 -1.8 -1.5 1.1
Prospective memory result 0.4 0.5 2.6 0.8 0.3 0.2 0.7 0.5 0.4 -1.1 -0.2 0.4 0.4 0.1 1.1 0.4 0.4 -1.0 -0.5 0.4 0.8 -0.6 -0.6 0.2 0.3 1.0 0.4 -1.0 1.6 0.7 1.0 1.1 0.4 1.1 -0.4
Lung cancer (father) 1.9 2.3 5.4 -1.2 -1.2 -1.5 -1.9 -1.4 -1.2 -1.4 -1.6 -1.7 -1.5 -1.2 -0.7 -1.7 -1.8 -0.9 1.6 -1.7 -1.3 1.6 1.4 -2.3 -1.8 -1.1 -1.6 1.5 -0.9 -1.9 -1.6 -1.6 -1.6 -1.6 1.1
Illnesses of mother 3.1 3.8 8.6 -0.7 -2.0 -2.5 -1.1 -1.4 -2.9 -2.1 -1.9 -2.4 -2.2 -2.9 -0.5 -2.5 -2.4 -1.4 1.6 -2.6 -1.6 1.8 0.9 -2.4 -2.7 -1.2 -1.9 1.8 -1.5 -2.1 -1.9 -1.8 -1.9 -1.9 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 1.1 0.5 -0.5 -0.4 0.6 0.0 -0.7 -0.5 -0.1 -0.2 -0.4 0.2 0.0 -0.1 0.2 -1.0 -0.3 0.2 -0.6 -0.1 -0.2 0.1 -0.3 0.6 0.3 -0.4 1.0 0.3 0.6 0.4 0.4 0.4 0.3
Pulse wave Arterial Stiffness index 0.6 0.7 2.0 -1.0 -0.4 -0.8 -0.8 -0.6 -0.8 -1.1 -0.8 -0.8 -0.6 -0.8 -0.2 -1.0 -1.1 -1.3 0.7 -1.4 -0.3 0.7 1.1 -1.0 -0.8 -0.7 -0.9 0.8 -0.9 -0.8 -0.8 -0.9 -0.9 -0.9 0.2
Impedance of arm (left) 5.5 25.6 36.5 -3.5 -3.0 -4.0 -5.2 -5.6 -5.8 -4.4 -4.8 -5.0 -3.8 -4.3 -6.0 -5.2 -5.2 -2.5 5.9 -5.8 -5.8 6.0 5.0 -6.0 -4.4 -4.9 -6.0 5.2 -3.9 -5.8 -5.3 -5.2 -5.8 -5.0 4.9
Arm fat mass (right) 0.6 2.5 10.2 0.0 2.3 1.7 1.7 2.1 1.2 0.7 1.3 2.4 2.1 0.8 2.7 0.9 -0.2 -0.5 -2.1 0.6 2.3 -2.2 -1.2 0.9 1.1 1.1 2.0 -0.9 -0.2 1.6 0.8 1.2 1.2 1.0 -3.2
Trunk predicted mass 2.7 15.7 30.4 3.2 2.6 2.9 4.7 4.6 3.8 2.7 3.0 4.0 3.0 2.6 5.5 3.5 3.0 0.8 -4.8 3.8 4.6 -4.9 -4.1 3.6 2.9 4.7 4.6 -4.5 3.9 4.4 4.3 4.6 4.2 4.5 -4.8
Standing height 0.1 1.4 6.1 0.5 -0.7 -1.0 -0.2 -1.1 -1.8 -2.2 -1.8 -0.9 -0.7 -1.7 -0.1 -1.4 -1.8 -1.5 1.0 -1.5 -1.1 0.9 0.8 -2.5 -1.4 0.5 -1.0 0.1 1.1 -1.0 -0.3 0.1 -1.6 0.2 0.5
Length of working week for main job 2.4 2.7 7.3 0.1 0.3 0.7 1.9 2.3 1.7 1.6 1.8 1.0 0.6 0.5 1.6 1.4 2.0 -1.0 -2.1 1.8 2.7 -2.0 -1.7 1.9 1.2 1.5 2.0 -1.6 1.0 1.9 1.7 1.6 2.1 1.5 -2.3
Exposure to tobacco smoke at home 1.0 1.1 4.1 -0.7 -0.9 -1.2 -1.0 -0.7 -0.7 -0.7 -2.0 -1.1 -1.0 -1.1 -0.6 -1.3 -1.4 -0.2 0.8 -1.1 -1.0 0.8 1.0 -1.9 -1.4 -0.5 -0.8 0.9 -0.7 -1.1 -1.0 -0.9 -0.9 -0.9 0.6
Breastfed as a baby 0.4 0.5 1.6 0.2 0.5 0.8 1.3 0.4 1.1 0.9 1.1 0.9 0.7 0.7 0.9 0.9 0.8 0.1 -0.7 1.0 0.6 -0.7 0.2 0.7 0.8 0.3 0.8 -0.5 0.1 0.7 0.7 0.5 0.7 0.5 -0.0
Tense / ‘highly strung’ 1.4 2.4 3.9 2.0 1.0 1.2 1.6 1.6 1.4 1.9 1.8 1.4 1.0 1.2 1.0 1.6 1.5 0.7 -1.7 1.5 1.3 -1.7 -1.3 1.7 1.2 1.9 1.7 -1.7 1.8 1.6 1.7 1.6 1.8 1.6 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 1.2 1.9 5.1 2.2 0.5 0.6 1.0 1.7 1.2 0.6 0.8 0.7 0.6 0.2 1.6 1.0 1.1 0.7 -1.4 0.9 1.7 -1.3 -2.1 1.7 0.8 2.0 1.2 -1.7 2.2 1.2 1.6 1.6 1.5 1.7 -1.4
Hair/balding pattern: Pattern 4 0.2 0.6 1.8 -1.1 0.7 0.4 -0.9 -0.7 -0.5 -0.5 0.0 0.2 0.4 -0.9 -1.1 -0.3 -0.9 0.6 0.7 -0.8 -0.5 0.7 0.7 -0.6 0.1 -1.1 -0.7 1.1 -1.4 -0.9 -1.1 -0.9 -0.9 -0.9 0.3
Birth weight of first child 6.2 11.3 19.8 2.5 2.2 2.8 2.7 3.5 2.9 3.0 3.1 3.0 2.8 2.3 3.2 3.6 3.8 0.5 -3.5 3.5 3.6 -3.5 -3.1 2.9 3.3 4.1 3.4 -4.3 4.4 3.8 4.3 4.4 3.5 4.5 -2.9
Peak expiratory flow (PEF) 0.7 1.6 3.6 0.2 -1.3 -1.4 -0.6 -1.5 -1.6 -1.7 -1.1 -1.6 -1.3 -1.0 -1.4 -1.4 -1.1 1.5 1.4 -1.4 -1.9 1.6 0.9 -0.7 -1.4 -0.0 -1.5 0.5 0.9 -1.5 -0.6 -0.7 -1.2 -0.5 1.6
Pulse wave reflection index 0.9 1.1 4.5 -0.4 -1.1 -1.2 -0.8 -0.9 -1.1 -0.9 -1.2 -1.0 -1.2 -1.4 -0.6 -1.2 -1.1 -2.1 0.8 -0.8 -0.6 0.7 1.2 -0.9 -1.2 -1.2 -0.7 1.2 -1.5 -0.8 -1.2 -1.0 -1.1 -1.1 0.3
Ever highly irritable/argumentative for 2 days 0.7 0.8 3.1 0.3 0.1 -0.0 1.2 1.4 0.6 0.7 -0.1 0.4 0.1 -0.1 1.4 0.6 0.6 -1.3 -1.3 0.7 1.3 -1.3 -1.6 0.1 0.2 0.9 1.2 -0.7 0.1 1.1 0.8 0.7 1.2 0.5 -1.8
Loud music exposure frequency 0.2 0.2 0.7 0.3 0.8 0.5 -0.4 -0.3 -0.5 -0.1 -0.2 0.6 0.8 0.4 0.1 0.1 -0.7 0.8 0.0 -0.1 -0.1 -0.1 0.4 0.6 0.1 0.7 0.3 -0.4 0.8 0.0 0.4 0.5 -0.4 0.5 0.2
Qualifications: O levels/GCSEs or equivalent 3.2 5.1 7.8 2.7 1.3 1.7 2.8 2.7 2.4 2.1 2.6 2.0 1.5 1.6 2.0 2.3 2.4 1.7 -2.5 2.1 2.5 -2.4 -2.0 2.4 2.0 2.5 2.4 -2.5 2.1 2.3 2.3 2.2 2.7 2.3 -2.2
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.1 -0.7 1.5 1.0 -1.1 -0.8 -0.8 -0.1 -0.4 0.5 1.2 0.5 -1.3 -0.2 -1.1 -0.2 0.8 -1.1 -0.7 0.8 1.0 -0.3 0.5 -0.5 -1.0 0.5 -0.1 -0.6 -0.6 -0.5 -1.0 -0.4 1.1
Blood clot in the leg (DVT) 0.4 0.5 1.8 -0.3 -0.9 -1.0 -0.8 -0.6 -0.5 -0.7 -1.2 -0.7 -0.9 -1.0 -0.2 -0.7 -0.7 -1.3 0.4 -0.2 -0.2 0.3 0.4 -0.5 -1.0 -0.6 -0.3 0.7 -0.8 -0.5 -0.8 -0.5 -0.7 -0.6 -0.1
Medication: Paracetamol 0.5 0.9 3.2 -0.6 -1.1 -1.5 -0.2 -0.6 -1.3 -0.7 -0.9 -1.2 -1.3 -1.2 -0.1 -1.4 -1.6 -1.0 0.6 -1.4 -0.9 0.6 0.6 -0.5 -1.8 0.0 -0.5 0.6 -0.0 -0.9 -0.7 -0.7 -0.8 -0.6 0.3
Headache pain in last month 1.0 1.7 3.7 1.0 -1.6 -1.4 -1.0 -1.4 -0.6 -0.8 -1.9 -1.6 -1.6 -0.5 -1.6 -1.3 -0.8 -1.6 1.3 -0.7 -1.0 1.3 1.2 -1.3 -1.2 -1.3 -1.3 1.5 -1.3 -1.6 -1.4 -1.6 -1.0 -1.7 1.0
Medication for cholesterol, blood pressure or diabetes 2.9 4.8 19.1 -1.6 -3.9 -4.0 0.5 0.1 -2.5 -2.1 -3.2 -2.8 -3.9 -3.9 2.1 -2.7 -1.7 -4.4 -0.1 -1.3 -0.6 -0.1 -0.2 -2.1 -3.9 -0.1 -0.1 0.7 -1.2 -0.5 -0.9 -0.7 -0.5 -0.9 -1.4
Glaucoma (self-reported) 0.4 0.4 1.2 -0.6 0.5 0.8 0.5 0.4 0.4 -0.1 -0.6 0.8 0.7 1.1 0.3 0.8 0.9 0.0 -0.6 0.8 0.2 -0.5 -0.3 0.6 0.9 0.3 0.6 -0.7 0.6 1.0 0.8 0.9 0.5 0.9 0.0
Gout (self-reported) 0.5 0.7 2.7 -0.5 -1.5 -1.2 0.3 -0.0 -0.8 -0.6 -1.1 -0.8 -1.3 -1.3 0.6 -0.5 0.0 -1.6 -0.2 0.5 0.1 -0.3 -0.9 -0.5 -1.0 -0.6 0.4 0.6 -1.3 -0.0 -0.6 -0.3 0.1 -0.7 -1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.8 -0.4 0.2 0.3 -0.2 0.5 0.5 0.3 -0.6 0.3 0.3 0.1 0.5 0.3 0.7 -0.7 -0.4 0.5 0.9 -0.5 0.5 0.1 0.6 0.3 0.4 -0.4 0.1 0.4 0.5 0.4 0.4 0.4 -0.5
Medication: Amlodipine 0.3 0.4 1.7 -0.3 1.3 1.1 -0.9 -0.3 -0.4 -0.7 1.1 0.5 1.1 0.3 -0.6 0.7 0.4 0.6 0.4 -0.1 0.1 0.5 0.6 -0.0 1.0 -0.7 -0.6 0.2 -0.2 0.1 -0.1 -0.0 -0.4 0.0 0.6
Medication: Ventolin 100micrograms inhaler 2.8 3.7 7.6 1.1 1.1 1.3 2.0 2.2 2.0 1.9 2.4 1.8 1.2 1.2 2.4 1.9 1.8 0.1 -2.3 2.1 2.5 -2.5 -1.7 1.3 1.5 2.0 2.4 -1.9 1.2 2.1 2.0 2.0 2.2 1.8 -2.7
Birth weight 4.6 10.0 17.1 1.4 4.0 4.1 3.1 2.8 3.7 2.4 4.0 4.1 4.1 3.8 2.3 3.7 2.5 2.2 -2.8 2.9 2.9 -2.9 -1.8 3.0 4.0 3.0 2.8 -3.3 3.2 3.0 3.0 3.4 2.7 3.6 -2.0
Chronic bronchitis/emphysema (mother) 1.2 1.4 6.4 -0.1 -0.3 0.2 -2.1 -1.7 -0.3 -0.6 -0.7 -0.5 -0.3 -0.2 -2.5 -0.2 0.2 -0.0 1.5 0.1 -0.9 1.4 2.5 -0.6 0.3 -1.8 -1.4 1.2 -1.0 -1.0 -1.1 -1.0 -1.2 -0.9 2.2
High blood pressure (siblings) 0.2 0.3 1.8 -0.2 0.9 0.8 -0.4 0.2 1.0 1.3 0.8 0.7 0.8 0.7 -0.3 0.6 0.3 -0.0 -0.2 0.4 0.6 -0.2 -0.1 0.3 0.8 -0.3 0.4 0.2 -0.7 0.3 -0.1 -0.2 0.3 -0.3 -0.1
Forced vital capacity (FVC), Best measure 0.1 0.3 1.8 0.9 -0.3 -0.0 0.9 0.0 -0.4 -0.2 0.3 0.1 -0.1 0.7 0.3 0.1 0.3 -1.1 -0.3 0.4 -0.6 -0.2 -0.1 0.2 0.0 0.8 0.4 -0.6 1.4 0.4 0.8 0.6 0.4 0.7 0.6
Body fat percentage 0.6 2.3 7.5 -1.7 0.5 -0.3 -1.4 -1.0 -1.5 -2.0 -0.9 -0.2 0.1 -1.4 -0.6 -1.7 -2.7 -1.1 1.1 -2.0 -0.7 1.0 1.8 -1.9 -1.1 -2.0 -1.1 2.0 -2.7 -1.3 -2.1 -1.7 -2.0 -1.8 -0.2
Leg fat percentage (right) 0.7 2.5 7.7 -1.8 -0.1 -0.6 -1.6 -1.4 -1.4 -2.1 -0.9 -0.6 -0.3 -1.4 -0.9 -1.7 -2.4 -0.6 1.3 -1.9 -0.9 1.3 2.2 -1.6 -1.2 -2.3 -1.3 2.1 -2.8 -1.3 -2.1 -1.8 -2.0 -1.9 0.6
Arm fat-free mass (right) 2.6 13.4 27.5 2.9 2.6 2.9 4.2 4.2 3.4 2.2 3.3 3.9 3.0 2.2 5.2 3.3 2.7 1.4 -4.4 3.5 4.5 -4.5 -3.6 3.3 2.7 4.2 4.3 -4.0 3.3 4.0 3.9 4.2 3.7 4.0 -4.5
Exposure to tobacco smoke outside home 2.8 3.7 5.6 -2.1 -1.2 -1.7 -1.6 -2.0 -1.9 -1.2 -2.0 -1.7 -1.4 -1.1 -1.5 -2.3 -2.3 -2.1 1.9 -2.1 -2.0 1.8 1.9 -2.1 -2.0 -2.2 -1.8 2.1 -2.4 -1.9 -2.1 -2.1 -2.2 -2.1 1.6
Comparative body size at age 10 5.4 14.8 29.1 -0.2 5.4 4.9 4.1 4.5 3.8 3.4 4.3 5.3 5.3 3.9 5.0 3.8 2.1 0.7 -4.3 2.5 3.9 -4.2 -3.8 3.4 4.3 3.1 4.2 -3.2 1.2 3.9 3.1 3.2 3.6 3.1 -4.8
Number of full brothers 4.9 6.1 13.8 -1.5 -1.1 -1.9 -2.2 -2.8 -2.8 -2.6 -2.0 -1.9 -1.6 -2.6 -1.8 -2.9 -3.7 0.1 2.6 -3.0 -3.3 2.4 2.6 -2.3 -2.6 -2.4 -2.1 2.8 -2.7 -2.6 -3.1 -2.6 -3.0 -2.6 1.9
Worry too long after embarrassment 0.3 0.5 3.6 -0.1 -1.4 -1.2 0.8 0.7 -0.7 0.7 -0.3 -0.8 -1.2 -0.7 0.8 -0.7 0.2 -1.9 -0.6 0.1 0.1 -0.4 -0.2 0.4 -0.9 -0.2 0.4 0.1 -0.6 0.4 0.0 -0.2 0.6 -0.2 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 1.0 0.7 1.0 1.0 0.3 0.9 0.8 0.5 0.3 0.9 0.8 0.5 0.7 0.9 0.6 -0.0 -0.8 0.6 0.8 -0.7 -0.5 0.5 0.9 0.9 0.6 -0.6 0.9 0.4 0.5 0.7 0.7 0.6 -1.0
Wheeze or whistling in the chest in last year 0.4 0.7 1.9 0.5 0.3 0.5 1.2 0.9 0.8 0.7 1.3 0.8 0.4 0.1 1.4 0.9 0.7 0.1 -1.0 1.4 0.8 -1.1 -0.4 0.7 0.4 0.5 1.2 -0.6 0.1 0.9 0.5 0.8 1.0 0.6 -1.1
Number of children fathered 0.7 0.8 3.1 0.2 -0.1 -0.3 -0.6 -1.3 -0.7 -1.1 -1.6 -0.6 -0.1 0.2 -1.2 -0.8 -0.9 1.6 1.2 -1.1 -1.4 1.2 1.2 -0.1 -0.4 0.0 -1.0 0.2 0.8 -0.9 -0.2 -0.4 -1.1 -0.2 1.7
Reason for reducing amount of alcohol drunk: Health precaution 4.5 5.3 8.4 1.9 1.9 2.1 2.2 2.2 2.5 2.4 2.8 2.2 2.0 2.0 1.7 2.8 2.4 2.2 -2.1 2.4 2.2 -2.1 -1.8 2.2 2.4 2.5 2.1 -2.8 2.9 2.4 2.5 2.6 2.3 2.8 -1.2
Age at first live birth 1.0 1.8 5.9 2.4 0.1 0.6 1.2 1.6 1.3 1.6 2.4 0.4 0.5 1.2 1.0 1.6 2.3 0.4 -1.2 1.3 1.1 -1.0 -2.0 0.6 1.2 1.1 0.9 -1.2 0.9 1.2 1.2 1.0 1.9 1.0 -1.3
Pulse wave peak to peak time 0.7 0.8 2.2 1.2 0.4 0.7 0.9 0.6 0.8 1.0 0.8 0.8 0.6 0.7 0.3 1.0 1.0 1.0 -0.8 1.5 0.3 -0.8 -1.1 0.8 0.8 0.8 1.0 -1.0 1.0 0.9 0.9 1.1 0.9 1.1 -0.3
Health satisfaction 0.1 0.1 0.6 0.3 -0.2 -0.3 -0.8 0.2 0.3 -0.1 -0.5 -0.2 -0.3 -0.8 -0.5 -0.2 -0.2 -0.1 0.0 -0.1 0.3 0.0 0.1 0.4 -0.3 0.3 0.0 -0.0 0.2 -0.2 -0.2 -0.0 0.1 -0.1 -0.1
Shortness of breath walking on level ground 0.4 0.5 1.8 -0.3 -0.4 -0.7 -1.3 -0.7 -0.0 -1.0 0.2 -0.5 -0.6 -0.8 -0.9 -0.9 -1.3 0.1 0.7 -0.7 -0.2 0.5 0.9 -0.7 -0.9 -0.1 -0.3 0.6 -0.0 -0.9 -0.7 -0.6 -0.7 -0.7 0.6
Qualifications: College or University degree 6.5 20.3 37.0 3.8 2.0 2.8 6.1 5.5 4.1 4.3 4.3 3.8 2.6 3.2 5.6 4.4 4.8 0.8 -5.5 4.7 5.1 -5.5 -4.8 4.5 3.4 4.8 5.5 -4.7 3.6 5.0 4.8 4.5 5.6 4.4 -5.5
Eye problems/disorders: None of the above 2.0 2.3 5.4 1.9 1.5 1.4 1.7 1.9 2.3 1.9 1.8 1.4 1.4 2.2 1.7 1.5 0.9 2.0 -1.5 0.9 1.3 -1.4 -1.2 1.0 1.1 1.8 1.4 -1.4 1.3 1.0 1.2 0.9 1.8 1.0 -1.3
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.6 0.2 0.7 1.0 0.5 1.0 1.1 1.1 1.2 1.0 0.9 1.1 0.5 1.1 1.2 0.7 -1.1 1.3 1.1 -1.1 -0.8 1.1 1.0 0.7 1.0 -1.0 0.7 1.2 1.0 1.0 1.1 1.0 -0.7
Emphysema/chronic bronchitis 0.4 0.4 1.7 -0.7 1.3 1.2 -0.4 -0.2 1.1 0.5 0.6 0.8 1.1 0.7 -0.2 0.5 0.0 1.3 0.3 -0.1 0.1 0.2 0.4 0.5 1.1 -0.4 -0.2 0.3 -0.5 -0.2 -0.3 -0.3 -0.2 -0.3 0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 3.9 1.3 1.3 1.5 1.5 1.6 1.6 1.1 0.8 1.6 1.5 1.4 1.7 1.5 1.4 1.2 -1.4 1.2 1.5 -1.4 -1.6 0.5 1.6 1.8 1.3 -1.9 1.9 1.6 1.8 1.9 1.4 2.0 -1.1
Neck or shoulder pain in last month 6.6 9.3 16.9 -2.1 -1.0 -1.7 -3.5 -3.5 -3.5 -2.4 -2.2 -2.5 -1.6 -2.4 -3.5 -2.8 -3.0 0.4 3.7 -3.3 -3.2 3.7 4.1 -2.9 -2.0 -3.6 -3.7 3.6 -3.0 -3.5 -3.6 -3.5 -3.6 -3.5 3.3
Medication: Blood pressure 2.9 5.2 12.4 1.5 3.0 3.4 1.3 1.5 2.9 2.8 3.5 3.0 3.3 3.3 0.9 3.0 2.5 2.0 -1.5 2.3 2.4 -1.6 -1.5 2.2 3.5 1.0 1.6 -1.6 1.2 1.9 1.8 1.7 1.8 1.7 -0.7
Angina (self-reported) 0.4 0.6 3.9 -0.6 1.0 0.8 -0.9 -0.9 0.3 0.2 0.5 0.4 0.9 0.5 -2.0 0.1 -0.3 1.7 0.8 -0.2 -0.9 0.6 0.8 0.6 0.6 -0.6 -0.5 0.5 -0.4 -0.6 -0.4 -0.4 -0.7 -0.4 1.0
Migraine (self-reported) 0.3 0.3 0.9 1.0 1.0 0.8 -0.7 0.0 0.6 0.1 0.6 0.6 0.9 0.5 -0.6 0.4 0.2 0.5 0.1 -0.1 0.4 0.2 0.8 0.3 0.9 0.4 -0.3 -0.5 0.9 0.2 0.4 0.6 -0.1 0.7 0.2
Medication: Ibuprofen 0.3 0.3 2.3 0.3 -0.9 -0.9 -0.0 -0.1 -0.4 0.1 -0.7 -0.7 -0.9 -1.1 -0.2 -0.5 -0.3 -1.5 0.1 -0.2 0.1 0.0 0.5 -0.3 -0.8 -0.2 -0.1 0.5 -0.5 -0.4 -0.5 -0.4 -0.0 -0.5 -0.4
Medication: Allopurinol 0.9 1.1 4.4 1.0 -0.7 -0.3 1.4 1.3 0.5 0.6 -0.4 0.2 -0.4 -0.2 1.4 0.6 1.2 -1.2 -1.3 1.5 1.4 -1.4 -2.1 0.7 0.1 0.7 1.4 -0.7 0.0 1.3 0.7 1.0 1.4 0.7 -2.0
Medication: Omeprazole 0.7 0.9 2.9 -1.7 -0.9 -1.2 -0.6 -0.3 -0.9 -0.5 -1.2 -1.0 -1.1 -1.2 -0.0 -1.0 -0.9 -1.5 0.4 -0.8 -0.4 0.4 0.6 -0.4 -1.2 -1.1 -0.4 1.1 -1.5 -0.6 -1.1 -1.2 -0.5 -1.2 0.1
Medication: Seretide 50 evohaler 0.2 0.2 1.3 -0.0 0.1 0.1 0.5 0.7 0.7 0.5 0.1 0.2 0.2 0.1 0.9 -0.1 0.0 -1.1 -0.5 -0.0 0.1 -0.4 -0.5 0.7 0.0 0.7 0.4 -0.5 0.4 0.3 0.3 0.4 0.5 0.4 -0.6
Mean time to correctly identify matches 2.5 4.7 15.8 -2.9 -1.9 -2.0 -2.4 -1.6 -2.2 -1.9 -3.0 -2.0 -2.0 -2.4 -1.7 -2.1 -1.5 -4.0 1.6 -1.5 -1.1 1.6 2.5 -2.5 -1.9 -2.8 -1.5 2.3 -3.1 -1.4 -2.1 -2.0 -2.0 -2.2 1.0
Heart disease (mother) 0.4 0.5 1.8 -0.2 1.4 1.4 -1.1 -0.5 0.6 -0.5 0.0 0.9 1.2 0.9 -1.1 0.7 0.4 0.5 0.5 0.4 -0.2 0.4 0.6 0.8 1.3 -0.6 -0.3 0.2 -0.1 0.0 -0.1 0.1 -0.3 -0.0 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.2 0.2 0.0 -0.0 -1.2 -1.0 0.3 -0.2 0.5 -0.4 -0.1 0.0 -1.0 -0.2 -0.3 1.5 1.0 -0.3 -0.9 1.0 0.7 -0.5 0.0 -0.6 -0.9 0.6 -0.0 -1.0 -0.6 -0.6 -0.8 -0.5 1.3
Whole body fat mass 0.1 0.6 2.5 -0.7 1.3 0.6 0.1 0.3 -0.2 -1.0 0.1 1.0 1.0 -0.6 1.1 -0.5 -1.6 -0.9 -0.4 -0.7 0.7 -0.5 0.4 -0.7 -0.2 -0.5 0.4 0.6 -1.4 0.0 -0.8 -0.3 -0.6 -0.4 -1.6
Leg fat mass (right) 0.1 0.5 2.0 -0.4 1.3 0.8 0.3 0.5 0.2 -0.8 0.5 1.2 1.2 -0.2 1.2 -0.1 -1.1 -0.2 -0.6 -0.3 0.9 -0.7 0.3 -0.0 0.1 -0.2 0.6 0.3 -1.1 0.4 -0.4 0.0 -0.3 -0.1 -1.4
Arm predicted mass (right) 2.8 14.1 27.7 3.0 2.6 3.0 4.3 4.3 3.6 2.4 3.5 3.9 3.1 2.3 5.3 3.5 2.9 1.2 -4.5 3.6 4.5 -4.6 -3.7 3.4 2.9 4.3 4.4 -4.1 3.5 4.1 4.0 4.3 3.8 4.1 -4.6
Pulse rate, automated reading 0.5 1.6 8.1 0.4 0.9 1.0 -2.0 -1.6 0.9 0.2 0.5 -0.1 0.8 1.4 -2.3 0.1 -0.0 2.8 1.8 -0.7 -0.6 1.7 1.1 0.2 1.0 -1.1 -1.8 0.9 -0.2 -1.5 -0.9 -1.1 -1.2 -0.9 2.5
Alcohol intake frequency. 0.9 2.0 4.0 0.5 1.5 1.8 0.7 1.3 1.6 1.3 1.4 1.8 1.7 1.8 0.9 1.9 1.7 -0.2 -1.3 1.8 2.0 -1.4 -1.3 1.3 1.9 0.7 1.5 -1.2 0.6 1.6 1.2 1.3 1.4 1.2 -1.1
Comparative height size at age 10 0.3 1.5 5.0 -1.0 -1.2 -1.4 -0.8 -1.0 -1.5 -1.8 -1.9 -1.2 -1.2 -1.7 -0.3 -1.5 -1.4 -1.9 1.0 -1.2 -0.9 1.0 1.0 -2.2 -1.6 -0.6 -1.2 0.7 -0.4 -1.1 -0.9 -0.6 -1.4 -0.7 0.6
Number of full sisters 0.8 1.0 2.1 -1.3 0.6 0.3 -1.4 -1.1 -0.3 -0.7 -1.3 -0.3 0.2 0.2 -0.8 -0.9 -1.0 1.2 1.2 -1.4 -0.8 1.4 1.1 -0.4 0.1 -0.9 -1.4 1.1 -0.9 -1.4 -1.1 -1.2 -1.2 -1.1 0.9
Suffer from ‘nerves’ 0.1 0.2 1.7 1.3 0.5 0.3 -0.6 -0.2 0.2 -0.1 0.0 -0.0 0.4 0.3 -0.2 0.0 -0.2 0.4 0.4 -0.7 -0.2 0.6 -0.1 -0.0 0.3 0.3 -0.8 0.0 0.8 -0.5 0.0 -0.2 -0.3 -0.1 0.7
Overall health rating 0.1 0.1 2.2 -0.2 0.1 -0.1 -0.2 0.0 -0.3 -0.1 -0.1 0.1 -0.1 -0.8 0.2 -0.2 -0.3 -1.5 -0.1 0.0 0.3 -0.1 0.2 -0.0 -0.3 -0.3 0.1 0.2 -0.6 0.1 -0.1 -0.1 -0.2 -0.2 -0.3
Chest pain or discomfort 1.0 1.5 3.5 -0.5 0.9 0.2 -1.8 -1.6 -0.2 -0.4 -0.5 -0.1 0.5 0.1 -1.8 -0.9 -1.8 1.7 1.6 -1.5 -1.6 1.5 1.3 -1.0 -0.2 -1.1 -1.4 1.2 -0.7 -1.4 -1.4 -1.1 -1.6 -1.0 1.9
Had major operations 0.3 0.3 1.4 0.7 0.4 0.4 -0.6 -0.7 0.8 0.8 -0.4 0.3 0.5 1.1 -1.2 -0.2 -0.4 -0.2 0.6 -0.1 -0.7 0.4 0.2 0.2 0.3 -0.3 -0.3 0.3 -0.2 -0.5 -0.4 -0.5 -0.4 -0.4 1.0
Age at last live birth 1.7 2.5 6.0 1.6 1.0 1.2 1.5 1.8 1.5 1.5 2.5 1.0 1.1 1.3 1.5 1.9 2.2 1.2 -1.5 1.5 1.7 -1.5 -2.2 0.8 1.6 1.5 1.3 -1.6 1.2 1.5 1.7 1.5 2.0 1.4 -1.7
Family relationship satisfaction 0.5 0.7 8.0 1.1 -1.1 -0.8 -0.3 0.5 0.3 0.5 -0.6 -0.5 -1.0 -0.6 -0.1 -0.1 0.7 -2.8 -0.5 0.8 0.8 -0.5 -0.4 0.3 -0.4 -0.5 0.6 0.5 -1.3 0.3 -0.2 -0.5 0.7 -0.8 -0.7
Leg pain on walking 3.3 4.2 9.0 -1.1 -2.1 -2.5 -1.8 -1.9 -2.5 -3.0 -2.5 -2.4 -2.2 -2.3 -1.1 -2.5 -2.1 -2.2 1.9 -2.1 -1.4 1.8 1.7 -2.1 -2.6 -1.8 -1.8 1.9 -1.7 -1.9 -1.8 -1.9 -2.1 -2.0 1.4
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 9.3 -1.0 -0.2 -0.4 -3.0 -1.8 -0.9 -1.3 -0.6 -0.9 -0.4 0.0 -2.3 -1.1 -1.4 0.1 1.9 -1.5 -1.6 2.0 1.6 -1.6 -0.5 -1.8 -1.9 1.8 -1.2 -1.9 -1.8 -1.8 -1.8 -1.8 2.0
Commuting to job workplace: Car/motor vehicle 1.4 1.6 3.4 -0.6 -0.7 -1.1 -1.4 -1.3 -1.1 -1.5 -0.7 -1.3 -0.8 -0.3 -1.2 -1.3 -1.5 0.6 1.5 -1.9 -1.2 1.6 1.7 -1.8 -1.2 -0.8 -1.7 1.0 -0.6 -1.4 -1.0 -1.1 -1.6 -1.0 1.4
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 2.2 0.3 0.5 0.1 -0.2 -0.5 -0.9 0.0 -0.2 -0.2 0.3 -0.3 -0.2 -0.4 -0.7 -0.5 0.7 -1.1 -0.5 0.8 0.2 -1.5 -0.1 -0.3 -0.9 0.1 -0.1 -0.3 -0.2 -0.1 -0.9 -0.0 0.5
Medication: Aspirin 1.2 1.6 6.6 -0.8 1.4 1.3 -1.8 -1.7 -0.3 -0.8 1.1 0.4 1.3 0.9 -2.6 0.1 -0.5 1.5 1.6 -0.5 -1.4 1.6 1.4 0.4 1.0 -1.5 -1.4 1.1 -0.6 -1.2 -1.0 -1.0 -1.4 -0.9 2.3
Supplements: Vitamin C 0.8 0.9 11.4 0.1 -1.3 -1.3 0.8 -0.2 -1.1 -0.9 -1.1 -0.7 -1.3 -1.0 0.3 -0.9 -0.6 -3.4 -0.0 -0.2 -0.4 -0.1 0.2 -0.9 -1.3 -0.8 0.1 0.6 -1.2 0.1 -0.6 -0.4 -0.4 -0.6 -0.3
Knee pain experienced in last month 1.3 1.9 5.2 -1.2 -1.5 -1.7 -1.1 -1.1 -1.8 -1.1 -1.3 -1.6 -1.7 -2.3 -0.3 -1.5 -1.5 -1.6 1.1 -1.3 -0.8 1.0 1.3 -1.6 -1.7 -1.2 -1.0 1.5 -1.7 -1.3 -1.4 -1.4 -1.3 -1.5 0.3
Hypertension (Self-reported) 0.7 2.0 6.0 -0.1 2.4 2.4 0.6 0.7 1.4 1.6 2.4 2.3 2.4 2.0 0.6 1.8 1.1 -0.3 -0.9 1.4 1.9 -1.1 -0.3 1.4 2.3 -0.3 1.0 -0.2 -0.8 1.1 0.5 0.5 0.7 0.3 -0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.1 -0.2 -0.2 -0.3 -1.3 -1.1 -0.1 -0.1 -0.7 -0.8 -0.4 -0.2 -1.1 -0.7 -0.5 -0.1 1.2 -1.0 -1.2 1.2 0.9 -1.0 -0.2 -1.4 -1.1 1.4 -1.3 -1.1 -1.2 -1.4 -0.8 -1.4 1.1
Illnesses of father: Heart disease 3.2 4.4 9.7 2.5 2.1 2.5 0.5 1.4 2.9 2.7 2.7 2.2 2.4 3.1 -0.6 2.5 2.4 2.8 -1.3 2.1 1.7 -1.2 -1.2 2.8 2.7 1.6 1.5 -2.0 2.0 1.8 2.0 1.9 1.8 2.0 -0.3
Illnesses of siblings: Diabetes 1.9 2.4 6.4 -1.1 0.3 -0.4 -1.4 -2.1 -1.8 -1.3 -0.8 -0.6 -0.2 -1.5 -1.3 -1.4 -2.3 -1.1 1.9 -1.8 -1.7 1.9 1.5 -1.9 -0.9 -1.7 -1.8 1.6 -1.4 -1.6 -1.7 -1.4 -2.5 -1.4 1.9
Smoking status: Previous 1.6 2.4 4.7 1.4 0.4 0.7 2.1 1.6 1.0 1.0 1.6 1.3 0.5 0.1 1.9 1.8 1.7 -1.2 -2.0 2.1 1.8 -2.2 -1.3 1.7 0.9 1.5 2.1 -1.4 1.0 1.8 1.6 1.6 1.8 1.4 -2.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 2.8 1.7 0.4 0.4 0.0 0.3 -0.0 -0.6 0.7 0.5 0.3 -0.3 0.5 0.3 0.1 -0.3 -0.4 0.3 0.5 -0.5 -0.1 0.3 0.3 0.8 0.5 -0.5 0.9 0.2 0.4 0.7 0.2 0.6 -0.7
Whole body fat-free mass 2.9 16.5 32.4 3.2 2.9 3.2 4.9 4.8 3.8 2.9 3.3 4.2 3.3 2.7 5.7 3.6 2.9 0.8 -5.0 3.7 4.7 -5.0 -4.3 3.6 3.0 4.8 4.8 -4.4 3.8 4.5 4.3 4.5 4.2 4.5 -5.1
Leg fat-free mass (right) 2.9 15.4 29.8 2.6 3.3 3.3 4.7 4.7 3.6 2.8 3.3 4.3 3.5 2.6 5.5 3.4 2.4 0.1 -4.9 3.4 4.5 -5.0 -4.3 3.3 2.9 4.5 4.8 -4.1 3.3 4.3 3.9 4.3 4.0 4.2 -5.3
Arm fat percentage (left) 0.2 0.8 5.3 -0.8 1.5 0.9 0.5 1.1 0.2 -0.2 0.6 1.3 1.2 -0.1 1.4 -0.1 -1.1 -1.1 -1.0 -0.4 1.2 -1.0 -0.1 -0.1 0.2 -0.1 0.9 0.3 -1.4 0.5 -0.4 0.0 0.1 -0.1 -2.3
Average weekly red wine intake 0.6 0.9 2.4 -0.3 0.3 0.1 -0.6 -1.1 -0.6 -0.6 -0.4 -0.1 0.0 0.0 -1.6 -0.7 -1.1 1.4 1.0 -0.8 -1.2 1.0 0.9 0.2 -0.2 -1.3 -0.8 1.4 -1.3 -1.2 -1.4 -1.5 -1.1 -1.5 1.0
Handedness (chirality/laterality): Left-handed 0.8 1.0 2.2 0.7 0.9 1.0 0.5 0.8 1.2 0.7 0.7 1.2 1.0 0.4 0.9 1.2 0.9 -1.0 -1.1 1.5 1.4 -1.2 -0.8 0.8 1.0 0.8 1.4 -1.0 0.7 1.2 1.0 1.1 1.0 1.0 -0.7
Mood swings 0.4 0.7 3.9 -0.6 -0.7 -0.6 0.9 0.9 0.6 1.2 0.5 -0.3 -0.7 0.2 1.1 0.1 0.8 -2.0 -0.9 0.5 0.5 -0.9 -0.4 -0.5 -0.3 -0.3 0.9 0.3 -1.4 0.5 0.1 -0.5 1.2 -0.7 -1.4
Loneliness, isolation 0.3 0.4 2.9 -1.6 0.3 0.1 0.2 0.1 -0.4 -0.6 0.4 0.2 0.2 0.2 0.4 -0.3 -0.5 -1.0 -0.1 -0.5 0.0 -0.1 0.9 -1.0 -0.2 -0.9 0.0 0.8 -1.7 0.1 -0.7 -0.7 -0.2 -0.8 -0.7
Long-standing illness, disability or infirmity 0.2 0.4 1.8 -1.4 0.1 -0.2 -0.5 -0.1 -0.5 -0.7 -0.4 -0.1 -0.2 -0.7 0.1 -0.6 -0.8 -1.0 0.2 -0.6 -0.2 0.1 0.6 -0.3 -0.5 -0.7 -0.2 0.8 -1.1 -0.4 -0.7 -0.8 -0.4 -0.9 -0.3
Ever had bowel cancer screening 0.4 0.4 3.4 -1.8 -0.9 -0.7 -0.4 0.3 0.1 -0.9 -1.1 -0.4 -0.8 -0.9 0.4 -0.3 0.3 -1.7 -0.2 0.3 0.7 -0.2 0.6 -0.1 -0.4 -0.2 0.2 0.0 -0.2 0.2 0.0 0.0 0.2 0.0 -0.5
Diabetes diagnosed by doctor 0.3 0.5 3.0 -1.7 1.5 1.1 0.1 0.1 -0.7 -0.1 0.1 1.2 1.2 1.0 0.6 0.0 -1.0 -0.1 -0.3 -0.3 0.2 -0.4 -0.1 0.1 0.4 -0.3 0.3 0.3 -0.8 0.1 -0.4 -0.1 -0.4 -0.1 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 3.3 3.5 7.9 -2.8 -0.1 -0.7 -1.6 -2.0 -1.6 -1.1 -1.2 -0.8 -0.7 -0.7 -1.2 -1.8 -2.5 0.5 1.8 -2.0 -2.1 1.8 1.7 -2.8 -1.3 -2.1 -1.7 2.6 -2.6 -2.4 -2.5 -2.7 -1.9 -2.8 1.3
Friendships satisfaction 0.2 0.3 1.0 0.7 0.3 0.4 0.5 0.6 0.7 0.8 0.8 0.3 0.3 0.4 0.4 0.4 0.8 -0.1 -0.6 0.3 0.6 -0.6 -0.4 0.6 0.6 0.2 0.6 0.0 -0.4 0.3 0.4 -0.2 0.9 -0.4 -1.0
Qualifications: nursing, teaching 1.9 2.9 4.9 1.3 1.8 2.0 2.0 1.4 1.9 1.3 2.1 2.2 1.9 1.8 1.4 1.8 1.4 1.5 -1.7 1.9 1.5 -1.8 -1.1 1.9 1.9 1.7 1.9 -1.7 1.5 1.7 1.7 1.8 1.5 1.9 -1.2
Commuting to job workplace: Walk 3.7 4.0 11.5 2.2 1.6 2.0 1.7 1.8 2.8 3.0 1.0 2.2 1.9 2.0 1.3 2.0 1.8 1.5 -1.9 2.2 1.8 -2.0 -2.2 3.4 2.1 2.2 2.1 -1.8 1.8 1.5 1.8 1.6 2.2 1.5 -1.6
Eye problems/disorders: Cataract 2.4 2.8 5.9 -0.9 -2.3 -2.2 -1.8 -1.6 -2.1 -1.8 -2.2 -2.2 -2.1 -2.4 -1.2 -2.0 -0.9 -2.3 1.5 -1.3 -1.2 1.5 0.7 -0.6 -1.8 -1.7 -1.4 1.6 -1.5 -1.3 -1.3 -1.5 -1.4 -1.5 1.1
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.6 0.4 -1.0 -1.1 -0.7 -0.8 -0.7 -0.9 -0.4 -1.3 -1.1 -1.2 -0.8 -0.8 -0.7 -0.2 1.0 -0.9 -0.9 1.0 0.4 -1.3 -1.1 -0.4 -0.8 0.6 -0.1 -0.9 -0.7 -0.6 -0.8 -0.6 0.5
Medication for cholesterol 0.7 1.0 5.3 0.7 -1.2 -1.0 2.3 1.2 0.3 0.2 -0.5 -0.2 -1.0 -0.8 2.2 -0.0 0.3 -1.6 -1.3 0.7 0.3 -1.2 -1.1 -0.6 -0.9 0.9 1.2 -0.7 0.2 1.0 0.6 0.6 1.2 0.5 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 3.1 0.4 0.2 0.1 1.0 1.3 0.2 0.7 0.7 0.4 0.3 0.3 1.1 0.6 0.5 -0.8 -1.1 0.5 0.8 -1.0 -1.0 0.4 0.1 1.7 1.0 -1.6 1.8 1.1 1.4 1.5 0.9 1.6 -1.1
Back pain experienced in last month 3.2 4.6 7.5 -1.4 -0.9 -1.6 -2.5 -2.4 -2.7 -2.1 -1.9 -1.9 -1.2 -1.8 -2.0 -2.5 -2.7 -1.0 2.4 -2.7 -2.4 2.4 2.3 -2.4 -1.9 -2.0 -2.5 2.1 -1.5 -2.3 -2.2 -2.2 -2.7 -2.0 2.3
Mineral and other dietary supplements 0.6 0.8 5.2 -0.7 2.3 1.9 -0.1 -0.5 0.6 0.7 0.4 1.5 2.0 1.2 -0.1 0.5 -0.7 1.6 0.3 -0.4 -0.8 0.3 0.5 0.1 1.2 0.3 -0.3 -0.2 0.7 -0.3 0.2 0.3 -0.7 0.5 0.8
Breast cancer (self-reported) 0.4 0.5 4.0 0.3 0.1 0.4 0.3 0.3 0.7 1.3 1.3 0.5 0.2 0.1 0.2 0.5 0.5 0.8 -0.5 0.9 0.4 -0.5 -0.1 2.0 0.4 0.6 0.7 -0.7 0.8 0.7 0.6 0.7 0.6 0.6 0.3
Asthma (self-reported) 2.2 4.3 8.1 1.3 0.7 1.0 2.1 2.6 2.3 2.4 2.4 1.4 0.9 1.0 2.7 1.9 2.2 1.0 -2.4 2.2 2.5 -2.4 -2.3 2.1 1.4 2.3 2.5 -2.1 1.7 2.2 2.1 2.1 2.6 2.0 -2.8
Osteoporosis (self-reported) 1.1 1.4 7.2 -1.1 1.2 1.0 -1.3 -1.6 0.1 0.2 -0.1 0.6 1.1 1.0 -1.3 -0.6 -1.4 0.8 1.4 -0.8 -1.8 1.3 1.8 0.2 0.3 -1.4 -1.2 1.0 -1.0 -1.0 -1.2 -1.1 -1.5 -0.9 2.7
Osteoarthritis (self-reported) 0.5 0.7 5.9 -0.1 -1.3 -1.3 0.1 -0.0 -0.8 -1.3 -0.9 -0.6 -1.2 -1.6 0.8 -0.6 -0.5 -2.4 -0.3 0.3 -0.2 -0.5 0.7 -0.1 -1.3 -0.1 0.5 0.2 -0.4 0.3 0.0 0.0 -0.2 -0.1 -0.5
Medication: Aspirin 1.1 1.5 6.0 -0.4 1.5 1.4 -1.7 -1.7 -0.3 -0.8 1.2 0.5 1.4 1.1 -2.5 0.1 -0.4 1.1 1.6 -0.5 -1.5 1.6 1.2 0.6 1.1 -1.3 -1.3 0.9 -0.3 -1.0 -0.8 -0.8 -1.3 -0.6 2.3
Medication: Gliclazide 0.3 0.4 2.4 -0.5 1.6 1.1 0.0 -0.3 -0.5 -0.7 0.8 1.1 1.1 0.8 0.2 -0.0 -1.1 0.4 0.1 -0.5 -0.7 0.0 0.1 -0.2 0.4 -0.2 -0.2 0.4 -0.5 -0.3 -0.4 -0.4 -0.5 -0.4 -0.1
Illnesses of father: None of the above (group 1) 2.4 3.0 8.5 -1.4 -1.4 -1.8 -1.1 -1.8 -2.1 -2.9 -2.1 -1.6 -1.7 -1.9 -0.5 -2.1 -2.3 -1.7 1.6 -1.8 -1.6 1.4 1.2 -1.8 -2.1 -1.6 -1.4 1.7 -1.7 -1.6 -1.8 -1.6 -2.0 -1.7 1.2
Smoking status: Current 2.7 4.3 10.4 -3.0 -1.1 -1.8 -1.5 -1.7 -2.1 -2.3 -2.6 -2.0 -1.4 -1.7 -0.9 -2.8 -2.9 -1.3 2.1 -3.2 -2.2 2.1 2.1 -2.2 -2.3 -1.4 -2.1 1.8 -1.4 -2.2 -2.1 -2.1 -2.2 -2.0 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.8 0.6 0.1 0.7 0.8 0.9 0.9 1.6 1.3 0.8 0.4 1.4 0.3 1.4 1.9 -0.2 -1.2 1.9 0.6 -1.1 -1.2 1.4 1.1 0.7 1.3 -1.0 1.1 1.4 1.3 0.9 1.7 0.9 -0.0
Whole body water mass 3.0 17.0 32.7 3.3 2.9 3.2 4.9 4.8 3.9 2.9 3.4 4.2 3.3 2.8 5.7 3.6 2.9 0.9 -5.0 3.8 4.8 -5.1 -4.3 3.7 3.0 4.9 4.9 -4.5 3.9 4.5 4.4 4.6 4.3 4.5 -5.1
Leg predicted mass (right) 2.7 14.3 28.6 2.5 3.2 3.1 4.5 4.6 3.4 2.6 3.1 4.2 3.4 2.4 5.3 3.3 2.2 0.1 -4.8 3.2 4.4 -4.8 -4.1 3.1 2.7 4.3 4.7 -4.0 3.1 4.1 3.8 4.1 3.9 4.0 -5.2
Arm fat mass (left) 0.6 2.3 9.8 0.1 2.1 1.6 1.5 2.1 1.3 0.5 1.5 2.3 2.0 0.7 2.6 0.9 -0.2 -0.2 -2.0 0.7 2.3 -2.1 -1.1 0.8 1.0 1.1 2.0 -0.9 -0.1 1.5 0.7 1.2 1.1 1.0 -3.1
Number of self-reported non-cancer illnesses 0.4 0.6 3.6 -0.1 1.2 1.2 -0.1 0.4 0.9 1.0 1.9 1.1 1.2 1.0 0.0 0.9 0.7 1.5 -0.3 0.5 0.7 -0.3 0.1 0.4 1.2 -0.5 0.3 0.2 -0.8 0.3 -0.1 -0.2 0.3 -0.2 -0.4
Average weekly champagne plus white wine intake 2.1 2.9 4.9 1.6 0.9 1.1 2.1 1.9 1.6 1.6 1.8 1.4 1.1 0.8 2.0 1.7 1.5 0.5 -1.9 1.6 2.2 -2.0 -2.1 0.7 1.2 2.2 1.9 -2.0 2.1 1.6 2.0 2.0 1.9 2.0 -1.9
Miserableness 1.2 2.0 4.2 -0.9 -1.8 -1.8 -0.8 -0.9 -1.1 -0.9 -1.1 -2.0 -1.9 -1.4 -1.0 -1.6 -0.8 -1.8 1.2 -1.3 -1.4 1.4 1.5 -1.0 -1.6 -1.6 -1.4 1.6 -1.9 -1.2 -1.5 -1.8 -0.8 -1.8 1.0
Guilty feelings 0.8 1.2 2.6 0.2 0.4 0.6 1.3 1.4 0.6 1.2 1.6 0.8 0.4 0.7 1.3 1.1 1.3 -0.2 -1.5 1.3 1.2 -1.4 -1.0 1.5 0.7 0.7 1.3 -0.9 0.2 1.4 1.1 0.8 1.6 0.7 -1.3
Wears glasses or contact lenses 0.5 0.5 1.5 1.0 0.5 0.6 0.7 0.7 0.1 0.7 0.4 0.6 0.6 -0.2 0.6 0.6 0.6 -0.5 -0.7 0.5 0.9 -0.7 -0.7 0.8 0.6 0.9 0.6 -1.0 1.2 0.8 0.9 1.2 0.6 1.2 -0.6
Ever taken oral contraceptive pill 1.1 1.2 3.5 0.6 0.7 1.0 1.2 1.0 1.9 0.5 1.0 1.1 0.8 1.4 0.4 1.2 1.1 0.4 -1.1 1.4 0.9 -1.1 -0.7 1.4 1.0 1.0 1.4 -1.2 0.7 1.5 1.1 1.3 1.1 1.2 -0.7
Hearing aid user 1.3 1.4 3.1 -1.4 -0.4 -0.6 -1.0 -1.6 -1.4 -1.0 -0.7 -0.7 -0.6 -1.2 -0.6 -0.9 -1.2 -0.4 1.3 -1.1 -1.3 1.2 1.6 -1.1 -0.8 -1.6 -1.2 1.5 -1.8 -1.3 -1.4 -1.4 -1.5 -1.4 1.1
Mother’s age at death 0.8 1.0 3.3 -1.6 0.7 0.6 1.4 1.4 0.8 0.7 -0.0 1.0 0.6 0.3 1.8 0.6 0.4 -0.5 -1.4 0.6 0.8 -1.4 -1.1 0.4 0.4 0.8 1.6 -0.9 -0.1 1.4 0.8 0.8 1.2 0.8 -1.7
Financial situation satisfaction 0.7 0.9 2.1 0.3 -1.3 -1.3 -0.7 -0.4 -0.1 -1.2 -0.7 -1.1 -1.4 -1.2 -0.6 -0.9 -0.6 -1.2 0.5 -0.5 -0.2 0.5 1.0 -0.7 -1.2 -1.0 -0.4 1.2 -1.5 -0.9 -1.2 -1.2 -0.4 -1.4 -0.2
Tinnitus: Yes, now most or all of the time 0.8 1.0 3.3 -0.4 1.6 1.7 -0.2 0.4 1.5 1.2 1.1 1.4 1.7 1.4 0.1 1.3 1.1 1.1 -0.4 0.9 1.1 -0.4 0.0 1.4 1.8 -0.1 0.3 -0.4 0.1 0.8 0.7 0.5 0.5 0.5 0.2
Commuting to job workplace: Public transport 1.9 2.3 4.4 1.2 0.9 1.3 0.9 1.9 1.6 2.1 1.4 1.4 1.1 0.9 1.5 1.6 1.8 0.2 -1.7 1.7 1.9 -1.7 -2.0 1.9 1.4 1.4 1.5 -1.4 1.1 1.4 1.4 1.4 1.9 1.3 -1.7
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 -0.7 -0.0 0.3 0.0 0.0 0.1 -0.4 -0.7 0.4 0.1 0.5 -0.2 0.3 0.5 -0.6 -0.3 0.7 0.0 -0.3 0.4 0.3 0.5 0.2 0.4 -0.4 0.4 0.5 0.5 0.7 0.1 0.7 0.1
Medication: Blood pressure 0.3 0.6 3.2 -0.1 1.8 1.4 -0.9 -0.4 0.0 0.1 0.8 0.9 1.6 1.2 -0.2 0.4 -0.4 0.8 0.6 -0.5 0.3 0.5 0.6 0.5 1.1 -0.8 -0.5 0.5 -0.8 -0.3 -0.5 -0.4 -0.7 -0.5 0.5
Pain type(s) experienced in last month: Hip pain 1.0 1.2 3.6 -1.9 -0.9 -1.2 -0.6 -0.6 -0.9 -1.1 -1.4 -1.1 -1.0 -0.9 0.1 -1.6 -1.4 -1.5 0.8 -1.5 -0.8 0.8 0.9 -1.0 -1.4 -1.0 -0.8 1.1 -1.4 -0.8 -1.0 -1.2 -1.0 -1.2 0.6
Supplements: Fish oil (including cod liver oil) 0.6 0.8 3.3 1.5 -1.8 -1.3 0.4 0.9 -0.2 0.4 -0.1 -0.8 -1.5 -1.0 0.5 0.2 1.2 -1.1 -0.8 1.1 1.2 -0.8 -1.1 0.2 -0.6 0.3 0.9 -0.4 0.0 0.9 0.5 0.4 1.2 0.2 -1.1
High cholesterol (Self-reported) 4.9 8.8 55.5 1.6 4.5 4.5 -2.6 -2.5 1.9 1.4 3.8 2.7 4.4 4.2 -6.0 1.9 0.4 7.5 2.2 0.3 -1.6 2.0 2.1 2.3 4.0 -1.4 -1.7 0.7 0.8 -1.3 -0.5 -0.6 -1.6 -0.3 4.0
Medication: Bendroflumethiazide 0.2 0.3 1.5 0.1 0.9 0.8 -0.2 0.2 -0.1 -0.1 0.8 0.6 0.9 0.9 0.6 0.3 0.1 -1.2 0.1 -0.2 1.0 -0.0 0.1 0.5 0.8 -0.4 -0.2 0.0 -0.4 0.2 0.0 0.1 -0.2 0.0 -0.1
Medication: Paracetamol 0.2 0.3 1.2 0.3 -0.8 -1.0 0.2 0.1 -0.8 -0.5 -0.0 -0.6 -0.8 -0.8 0.1 -0.7 -0.8 -1.0 -0.0 -0.6 0.0 -0.1 -0.0 0.0 -1.1 0.6 -0.0 -0.2 0.8 -0.1 0.1 0.2 -0.2 0.2 -0.3
Medication: Lisinopril 2.2 2.8 5.1 0.6 2.2 2.2 1.5 1.4 1.5 0.8 2.1 2.2 2.2 1.8 1.3 2.0 1.4 1.0 -1.5 1.6 2.3 -1.6 -1.2 2.0 2.2 1.2 1.6 -1.7 1.1 2.0 1.7 1.9 1.2 1.8 -1.2
Medication: Atorvastatin 2.6 3.2 18.4 -0.0 0.3 0.1 -2.6 -2.3 -0.8 -0.6 0.1 -0.7 0.2 0.3 -4.3 -0.7 -0.9 3.9 2.3 -1.3 -1.9 2.3 2.0 0.2 0.1 -1.9 -2.2 1.6 -0.9 -1.9 -1.6 -1.7 -1.9 -1.6 2.7
Illnesses of father: High blood pressure 2.9 3.6 10.2 1.4 2.2 2.4 1.3 1.6 2.2 3.2 2.2 2.3 2.2 2.4 0.8 2.1 1.4 2.1 -1.7 1.7 1.3 -1.7 -1.7 1.9 2.1 1.9 2.0 -1.8 1.9 1.8 1.7 1.7 1.8 1.7 -0.9
Alcohol drinker status: Never 0.2 0.2 1.3 0.2 -0.1 -0.1 -1.1 -0.5 -0.0 0.7 0.1 -0.1 -0.1 0.1 0.1 -0.1 -0.4 1.1 0.4 0.2 0.2 0.3 0.3 -1.0 -0.1 -0.2 -0.2 0.3 0.2 -0.5 -0.4 -0.2 -0.4 -0.3 0.7
Ever smoked 1.5 2.6 7.5 0.1 0.3 0.4 2.6 2.1 0.9 1.1 0.8 1.2 0.4 0.4 2.3 1.2 1.1 -1.5 -2.3 1.7 1.9 -2.5 -1.2 1.8 0.4 1.6 2.6 -1.4 0.5 2.0 1.5 1.4 2.0 1.2 -2.7
Basal metabolic rate 2.3 12.7 26.3 2.7 2.8 2.9 4.3 4.2 3.3 2.3 3.0 3.9 3.1 2.3 5.1 3.1 2.2 0.6 -4.4 3.1 4.2 -4.5 -3.6 3.0 2.6 4.2 4.3 -3.8 3.1 3.9 3.6 4.0 3.6 3.9 -4.7
Leg fat percentage (left) 0.7 2.6 8.8 -1.9 0.0 -0.7 -1.5 -1.3 -1.5 -2.2 -0.8 -0.5 -0.3 -1.5 -0.7 -1.7 -2.5 -1.1 1.2 -1.8 -0.9 1.1 2.2 -1.9 -1.3 -2.3 -1.1 2.2 -3.0 -1.3 -2.2 -1.8 -2.1 -2.0 0.3
Arm fat-free mass (left) 2.2 11.4 23.7 2.6 2.5 2.7 3.8 3.9 3.3 2.1 2.8 3.6 2.9 2.3 4.9 3.0 2.3 0.8 -4.1 3.1 4.1 -4.2 -3.3 3.0 2.5 3.9 4.0 -3.7 3.1 3.8 3.5 3.8 3.4 3.7 -4.2
Number of operations (self-reported) 0.2 0.3 0.9 -0.7 0.3 0.1 -1.0 -0.7 -0.1 -0.0 -0.0 -0.0 0.1 0.1 -0.2 -0.5 -0.9 0.2 0.6 -0.6 -0.7 0.6 0.8 -0.2 -0.3 -0.1 -0.6 0.3 -0.1 -0.7 -0.5 -0.4 -0.7 -0.3 0.9
Average weekly beer plus cider intake 2.6 3.7 7.2 -1.9 -0.6 -1.0 -2.4 -2.3 -2.1 -1.8 -1.6 -1.6 -1.0 -1.3 -2.4 -1.7 -1.9 -0.3 2.3 -2.1 -2.6 2.4 2.3 -2.4 -1.2 -2.1 -2.4 1.8 -1.4 -2.0 -1.9 -1.8 -2.3 -1.6 2.7
Irritability 1.5 2.5 7.0 2.6 -0.2 0.1 2.1 1.9 0.9 2.0 0.4 0.5 -0.1 0.1 1.6 1.3 1.8 0.8 -2.0 1.6 1.7 -1.9 -2.2 1.4 0.6 1.9 2.0 -1.5 1.5 1.5 1.9 1.5 2.2 1.4 -2.2
Risk taking 0.2 0.3 1.7 -0.9 -0.2 -0.2 -0.2 -0.2 0.5 0.5 -0.9 -0.1 -0.3 0.4 0.2 -0.3 -0.3 -0.3 0.1 0.0 0.1 0.0 0.2 -0.1 -0.3 -0.8 0.0 0.9 -1.3 -0.5 -0.8 -1.0 0.0 -1.1 0.2
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.5 -0.7 -0.2 -0.3 -0.5 -0.2 0.3 -0.1 -0.1 -0.3 -0.2 -0.0 -0.2 -0.2 -0.2 0.5 0.2 -0.2 -0.1 0.2 -0.1 0.0 -0.3 0.1 -0.1 0.1 0.2 -0.3 -0.1 -0.2 -0.1 -0.2 0.4
Fractured/broken bones in last 5 years 0.9 1.2 3.1 0.1 -0.3 -0.2 -1.8 -1.3 -0.9 -0.8 -1.8 -0.7 -0.3 -0.2 -1.8 -0.9 -0.8 0.8 1.4 -1.1 -0.8 1.4 1.4 -0.4 -0.4 -1.0 -1.5 1.0 -0.4 -1.3 -1.1 -1.1 -1.2 -1.0 1.6
Age started oral contraceptive pill 1.0 1.2 3.3 -1.8 -1.5 -1.4 -0.5 -0.8 -1.5 -0.6 -1.1 -1.1 -1.3 -1.6 -0.4 -1.2 -0.8 -1.5 0.7 -0.4 -0.8 0.6 0.4 -1.2 -1.4 -1.6 -0.5 1.2 -1.8 -0.4 -1.2 -1.0 -0.9 -1.1 0.4
Diastolic blood pressure, automated reading 0.3 1.0 3.8 0.7 1.8 1.8 0.5 0.5 2.0 0.8 1.4 1.6 1.8 1.8 0.5 1.0 0.4 1.2 -0.4 0.5 0.7 -0.4 -0.1 1.2 1.5 0.5 0.2 -0.6 0.7 0.4 0.6 0.4 0.3 0.6 0.3
Ever depressed for a whole week 0.7 0.8 2.8 1.4 -0.4 -0.3 0.9 1.2 1.0 1.0 0.1 -0.0 -0.4 -0.0 0.6 0.4 0.7 1.7 -1.0 0.5 1.2 -1.0 -1.1 0.3 -0.1 1.6 1.2 -0.8 1.2 0.4 0.8 0.6 1.3 0.6 -1.4
Unable to work because of sickness or disability 0.1 0.1 1.3 -0.3 -0.0 -0.0 0.1 0.3 0.6 1.1 -0.0 0.1 -0.1 -0.0 0.2 0.2 0.2 -1.1 -0.4 0.4 0.3 -0.3 0.4 0.1 -0.0 -0.1 0.4 -0.2 -0.3 0.5 0.1 0.2 0.3 0.1 -0.2
Commuting to job workplace: Cycle 0.5 0.7 2.1 -1.1 1.3 1.3 0.7 0.4 0.5 0.5 1.3 1.5 1.4 1.2 0.5 0.6 -0.0 -1.1 -0.7 0.6 0.0 -0.9 -0.1 0.9 0.7 0.2 1.0 -0.4 -0.2 0.9 0.4 0.6 0.4 0.5 -0.3
Myopia 3.9 5.7 12.2 0.6 1.9 2.0 3.5 3.0 2.1 1.8 2.4 2.2 2.0 2.0 3.2 2.6 2.4 0.1 -2.9 1.9 2.2 -2.7 -2.9 2.3 2.0 2.2 2.7 -2.4 1.5 2.8 2.5 2.2 3.0 2.2 -2.8
Vascular/heart problems diagnosed by doctor 0.7 2.0 6.4 0.1 -2.5 -2.5 -0.4 -0.8 -1.6 -1.9 -2.2 -2.3 -2.5 -2.2 -0.4 -1.8 -1.2 0.2 0.8 -1.3 -1.8 1.0 0.2 -1.3 -2.4 0.2 -1.0 0.3 0.6 -0.9 -0.6 -0.5 -0.8 -0.3 0.7
Cholesterol lowering medication 3.2 4.7 20.6 -1.2 2.9 2.5 -2.9 -2.8 0.5 -0.1 1.6 1.3 2.5 2.4 -4.5 0.3 -1.1 4.1 2.5 -1.0 -1.9 2.2 2.3 0.3 1.9 -2.1 -2.0 1.6 -0.9 -1.8 -1.5 -1.5 -2.4 -1.3 3.4
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 4.0 -0.9 -0.9 -1.0 -0.7 -0.5 -0.8 -0.3 -1.0 -0.9 -1.0 -1.1 -0.2 -0.8 -0.7 -1.2 0.5 -0.6 -0.4 0.5 0.6 -0.5 -1.0 -1.4 -0.5 1.4 -2.0 -0.8 -1.3 -1.4 -0.5 -1.5 0.1
Pain experienced in last month 3.9 6.5 11.9 1.2 3.0 3.1 2.3 2.2 3.1 1.8 3.5 3.2 3.2 2.7 1.8 3.1 2.2 2.3 -2.4 2.2 2.0 -2.3 -2.6 2.6 3.0 2.5 2.3 -2.7 2.6 2.5 2.6 2.7 2.2 2.8 -1.9
Supplements: Calcium 0.4 0.4 3.5 -0.4 0.5 0.5 -0.1 -0.2 1.0 1.0 0.4 0.1 0.5 1.3 -0.5 0.4 0.6 1.9 0.5 -0.1 -0.1 0.5 0.2 0.4 0.7 -0.2 -0.4 0.2 0.0 -0.4 -0.0 -0.7 0.3 -0.5 0.9
Basal cell carcinoma (self-reported) 0.3 0.4 1.6 -0.2 1.2 1.1 0.3 -0.1 1.3 0.6 1.1 1.0 1.1 0.8 0.4 0.6 0.1 -0.7 -0.1 0.3 0.1 -0.1 -0.2 0.1 0.8 -0.4 0.2 0.1 -0.5 0.3 0.0 -0.0 0.0 -0.0 0.6
Heart attack/myocardial infarction (self-reported) 0.7 0.9 3.7 0.1 1.7 1.6 -1.1 -0.6 1.0 0.1 1.3 0.9 1.6 1.3 -1.5 0.7 0.2 1.9 0.6 -0.0 -0.0 0.6 0.5 0.3 1.4 -0.8 -0.5 0.5 -0.6 -0.5 -0.4 -0.5 -0.5 -0.4 0.9
Deep venous thrombosis (DVT) (self-reported) 0.6 0.8 1.7 -0.5 -1.0 -1.0 -1.2 -0.9 -0.6 -0.8 -1.3 -0.9 -1.1 -1.0 -0.4 -0.9 -0.9 -1.1 0.7 -0.4 -0.5 0.6 0.8 -0.6 -1.1 -1.0 -0.5 1.0 -1.2 -0.9 -1.1 -0.8 -0.9 -1.0 0.3
Heart disease (siblings) 1.6 1.9 5.4 -1.6 0.6 -0.1 -1.8 -2.0 -0.8 -1.2 -0.4 -0.3 0.2 -0.7 -1.8 -1.2 -2.3 1.0 1.7 -1.7 -1.6 1.5 1.5 -0.8 -0.7 -1.4 -1.2 1.5 -1.2 -1.4 -1.4 -1.3 -2.1 -1.3 2.0
Alcohol drinker status: Previous 1.8 2.0 3.8 1.0 1.4 1.7 0.5 1.3 1.2 0.9 1.7 1.5 1.5 1.1 0.7 1.9 1.9 1.4 -1.2 1.6 1.8 -1.2 -0.9 1.7 1.9 1.3 1.2 -1.5 1.4 1.4 1.5 1.6 1.3 1.5 -1.1
Pack years of smoking 5.3 7.8 14.9 -2.5 -2.5 -2.8 -3.7 -2.8 -2.4 -3.9 -3.1 -3.0 -2.8 -3.1 -2.6 -3.0 -2.7 -0.7 2.9 -2.6 -2.0 2.8 2.9 -3.0 -2.8 -2.7 -2.9 2.9 -2.5 -3.1 -3.0 -2.5 -3.2 -2.6 1.9
Impedance of whole body 8.3 42.2 63.8 -4.1 -3.8 -4.8 -7.1 -7.7 -7.0 -5.9 -5.9 -6.2 -4.7 -5.0 -8.0 -6.4 -6.4 -1.7 7.9 -7.1 -7.6 7.9 6.8 -7.3 -5.3 -6.6 -7.9 6.7 -4.9 -7.4 -6.8 -6.6 -7.7 -6.5 7.4
Leg fat mass (left) 0.1 0.6 2.7 -0.4 1.3 0.7 0.4 0.6 0.2 -0.8 0.5 1.3 1.1 -0.3 1.3 -0.1 -1.2 -0.5 -0.7 -0.3 0.9 -0.8 0.2 -0.3 0.1 -0.2 0.8 0.3 -1.2 0.4 -0.4 0.0 -0.3 -0.1 -1.6
Arm predicted mass (left) 2.3 11.6 24.8 2.6 2.7 2.8 3.9 3.9 3.3 2.1 3.0 3.8 3.0 2.3 5.0 3.1 2.2 1.2 -4.1 3.1 4.0 -4.2 -3.3 2.9 2.6 3.9 4.1 -3.7 3.0 3.8 3.5 3.8 3.4 3.7 -4.2