Hub : Genes

SNCA

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0250	1.7e-04	0.032	0.030	0.030	0.031	0.036	8.0e-05	1.1e-04	1.4e-04	1.1e-04	2.6e-05
2	GTEx	Artery Aorta	0.0890	0.0370	3.8e-03	-0.005	NA	0.015	NA	-0.005	7.5e-01	NA	4.9e-02	NA	7.8e-01
3	GTEx	Artery Tibial	0.0562	0.0261	7.5e-03	0.048	NA	0.027	NA	0.035	1.2e-04	NA	3.3e-03	NA	9.0e-04
4	GTEx	Brain Caudate basal ganglia	0.2290	0.0870	4.1e-03	-0.006	NA	-0.007	NA	-0.004	5.2e-01	NA	6.0e-01	NA	4.2e-01
5	GTEx	Heart Left Ventricle	0.1636	0.0567	3.7e-05	0.152	NA	0.109	NA	0.142	1.8e-08	NA	2.2e-06	NA	5.3e-08
6	NTR	Blood	0.0376	0.0112	2.5e-06	0.033	0.024	0.028	0.028	0.030	8.2e-11	2.0e-08	1.3e-09	1.3e-09	3.7e-10
7	YFS	Blood	0.0749	0.0162	2.2e-16	0.076	0.057	0.070	0.070	0.073	1.4e-23	5.9e-18	4.9e-22	8.8e-22	1.2e-22
8	TCGA	Bladder Urothelial Carcinoma	0.0360	0.0210	6.0e-03	0.008	0.026	0.004	NA	0.006	6.4e-02	2.6e-03	1.4e-01	NA	9.7e-02
9	TCGA	Breast Invasive Carcinoma	0.0455	0.0177	6.9e-11	0.036	0.048	0.053	NA	0.051	5.4e-08	3.8e-10	4.1e-11	NA	1.2e-10
10	TCGA	Lung Adenocarcinoma	0.0509	0.0247	2.6e-05	0.052	0.042	0.036	NA	0.040	9.4e-07	1.1e-05	4.1e-05	NA	1.6e-05
11	TCGA	Prostate Adenocarcinoma	0.1554	0.0466	1.1e-16	0.162	0.149	0.168	NA	0.159	1.1e-16	2.6e-15	3.0e-17	NA	2.3e-16

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.7	1.2	3.5	-1.4	-0.5	-0.7	1.2	-1.1	-0.5	0.3	1.9	1.2	1.3	-0.7
Bipolar Disorder or Schizophrenia	1.1	2.6	6.3	-2.5	-1.2	-1.3	2.1	-1.5	-0.3	0.4	2.3	1.4	2.1	-1.0
Depressed Affect (Nagel 2018)	6.3	13.2	24.8	3.0	3.3	4.2	-1.9	5.0	-2.8	-2.5	-3.5	-4.1	-4.2	4.3
Depression (Nagel 2018)	6.8	10.2	18.8	2.6	2.8	3.7	-1.8	4.3	-1.8	-1.8	-2.9	-4.0	-4.0	3.9
Intelligence (Savage-Jansen 2018)	1.1	3.3	6.0	0.6	1.2	1.7	-2.4	2.0	-2.0	-2.2	-1.0	-1.5	-2.0	2.2
Neuroticism (Nagel 2018)	7.9	18.6	32.1	3.7	3.4	4.8	-3.3	5.7	-3.5	-3.3	-3.7	-4.9	-5.1	5.1
Schizophrenia (2018)	0.8	1.6	4.4	-2.1	-1.2	-1.1	1.8	-1.0	0.1	0.3	1.4	0.8	1.6	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	1.0	0.8	0.4	-0.2	0.5	-0.2	-0.7	-0.7	-0.8	-0.7	0.8
Worry (Nagel 2018)	10.2	21.5	36.7	3.7	4.3	5.0	-3.3	6.1	-3.9	-3.9	-3.6	-5.0	-5.5	5.6
Alzheimer’s Disease (in mother)	0.1	0.1	1.2	0.2	-1.1	-0.2	-0.1	-0.2	-0.1	-0.2	-0.0	0.3	0.1	-0.1
Alzheimer’s Disease (in father)	1.3	1.4	3.8	1.1	1.3	1.0	0.0	1.3	0.1	-0.2	-1.5	-2.0	-1.4	1.3
Alzheimer’s Disease (including proxy)	0.9	1.4	3.4	1.7	0.6	0.7	0.2	1.3	0.4	0.1	-1.9	-1.7	-1.4	1.1
Crohns Disease (2017)	0.7	1.4	4.9	0.9	2.2	1.2	-1.3	0.9	-0.9	-1.3	-0.6	-1.2	-1.0	1.0
Irritable Bowel Disease (IBD)	0.1	0.2	0.6	-0.3	0.7	-0.0	0.1	0.2	-0.5	-0.8	0.4	-0.3	-0.0	0.2
Ulcerative Colitis (UC)	0.5	0.9	2.6	-1.6	-1.0	-0.8	1.1	-0.2	-0.7	-0.8	1.5	0.6	0.9	-0.1
Major Depression (MDD)	0.7	0.8	4.0	-0.4	-0.5	0.7	-2.0	1.0	-0.3	-0.7	-0.7	-0.8	-0.7	1.0
Reaction Time	1.4	2.7	5.7	-1.4	-1.9	-1.6	-0.2	-2.4	0.4	0.5	1.8	2.0	2.1	-1.9
Verbal and Numeric Reasoning (VNR)	0.3	0.8	3.8	0.8	0.7	0.5	-1.9	0.8	-0.7	-0.6	-0.5	-0.8	-0.9	0.6
Breast Cancer	0.1	0.2	1.0	0.4	1.0	-0.4	0.4	-0.5	-0.1	0.4	0.4	0.2	0.1	-0.7
Ovarian Cancer	2.6	3.5	11.0	1.7	2.0	1.3	-1.0	2.0	1.6	1.3	-3.3	-2.2	-2.0	0.8
Prostate Cancer	1.3	1.9	3.9	-0.6	-1.4	-1.6	2.0	-1.2	1.1	1.5	1.3	1.0	1.4	-1.7
Age at First Birth	0.1	0.2	0.9	-0.0	-0.1	0.2	0.0	0.1	-1.0	-0.7	0.3	0.2	0.2	0.4
Bipolar Disorder (2011)	0.8	0.8	2.3	-1.5	-0.6	-0.7	0.0	-0.5	-0.7	-0.3	1.4	1.2	1.0	-0.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.9	0.4	0.8	-0.2	-0.5	-0.7	1.0	1.0	-0.3	0.2	0.6	-0.7
Coronary Artery Disease (CAD)	0.4	0.4	3.3	0.6	-0.3	0.2	1.8	-0.2	0.7	-0.1	-0.5	-0.2	-0.1	-0.3
Crohns Disease (2012)	0.2	0.3	1.5	1.0	1.2	0.0	-0.7	-0.2	0.5	0.3	-0.2	-0.4	-0.1	-0.3
Mean Putamen Volume	0.3	0.4	1.3	0.5	-0.2	-0.3	0.2	-1.1	0.5	0.3	0.4	0.6	0.6	-1.0
Fasting Glucose	0.2	0.2	0.5	-0.5	0.6	0.1	0.4	0.3	-0.7	-0.6	0.4	-0.3	-0.2	0.3
HbA1C	2.7	3.0	7.6	0.2	1.1	1.9	-0.6	2.0	-2.4	-2.8	-0.6	-1.1	-1.5	2.4
HDL Cholesterol	0.5	0.9	3.1	-0.3	-0.1	-1.1	1.8	-1.0	0.9	0.9	0.4	1.2	0.4	-1.0
LDL Cholesterol	0.2	0.2	1.3	0.4	-0.5	0.3	-1.1	0.5	0.0	-0.0	-0.2	-0.4	-0.6	0.4
Lupus	0.4	0.7	2.1	-0.1	0.5	0.5	1.1	0.5	-1.4	-1.3	0.2	-0.6	-0.2	1.1
Neuroticism (2016)	5.0	7.2	17.7	0.4	1.0	2.2	-2.7	3.5	-4.2	-3.2	-0.8	-2.1	-2.5	3.7
Primary Biliary Cirrhosis	0.1	0.2	0.9	-0.3	-0.4	0.3	0.4	0.3	0.7	0.4	-0.9	-0.2	0.0	0.2
Rheumatoid Arthritis	0.1	0.1	0.5	0.4	-0.7	-0.4	-0.5	0.1	0.3	0.6	0.1	-0.0	-0.0	-0.3
Schizophrenia (2014)	1.9	4.1	7.3	-2.7	-2.2	-2.1	2.3	-2.0	0.6	0.8	2.3	1.9	2.5	-1.7
Triglycerides	0.4	0.6	1.8	-1.3	0.5	0.5	-1.2	0.6	-0.9	-1.0	0.4	-0.4	-0.0	1.0
Type 2 Diabetes (T2D) (2012)	2.0	2.3	8.1	2.8	1.1	2.0	-0.3	0.9	0.1	-0.3	-1.8	-1.9	-1.8	1.0
Ulcerative Colitis	0.2	0.3	1.9	-0.6	-1.4	-0.8	-0.4	0.3	0.1	0.1	0.7	0.2	0.0	-0.1
Blood Eosinophil Count	0.2	1.4	2.9	1.2	1.1	1.7	-0.9	0.8	-0.5	-0.7	-1.2	-1.7	-1.3	1.1
Blood Platelet Count	0.1	0.8	3.4	-1.8	-0.4	-1.3	0.2	-0.7	0.6	0.3	0.6	1.4	0.5	-0.3
Blood Red Count	0.7	6.4	11.0	2.5	1.3	3.3	-1.6	3.2	-1.6	-1.9	-2.5	-2.6	-3.2	2.9
Blood White Count	0.1	0.4	1.1	0.3	0.1	-0.3	0.6	-1.0	1.1	0.5	0.1	0.5	0.6	-1.0
Heel T-Score	0.1	1.1	2.6	-0.2	-1.1	-0.8	1.1	-1.4	1.2	1.6	0.5	0.6	1.0	-1.1
BMI	0.5	3.1	10.0	3.2	1.1	0.4	-0.4	-1.0	2.8	2.7	-1.9	-0.7	-0.4	-1.5
Height	0.7	14.2	22.0	-2.9	-3.8	-4.3	2.2	-4.7	3.2	3.3	3.7	3.5	4.4	-4.5
Waist Hip Ratio (WHR)	0.3	1.5	3.4	0.0	-0.2	1.1	-1.1	1.6	-1.6	-1.8	-1.0	-0.6	-1.2	1.6
Systolic Blood Pressure	0.4	1.8	5.3	0.6	-2.3	-1.0	1.8	-1.4	1.4	1.5	0.8	0.6	0.7	-1.6
Smoking Status	1.0	2.3	5.4	-2.0	-1.6	-1.6	1.3	-1.3	-0.6	-0.5	2.3	1.6	1.9	-1.0
Allergy or Eczema	0.2	0.5	1.5	1.2	0.7	0.2	1.0	-0.1	0.5	0.7	-0.7	-0.9	-0.2	-0.4
Cardiovascular Disease	0.2	0.7	3.0	0.6	-0.4	0.9	-0.6	0.5	-1.7	-1.5	0.6	-0.3	-0.3	0.7
Hypothyroidism (self reported)	0.9	2.0	5.8	-0.5	-1.4	-1.1	1.2	-1.2	2.3	2.4	-0.2	0.9	1.1	-1.6
Respiratory disease	0.3	0.7	2.6	1.4	1.6	0.2	-0.4	0.3	0.3	0.5	-1.2	-0.9	-0.9	0.1
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.2	1.0	0.9	1.1	-0.6	0.3	-0.2	-0.2	-0.8	-1.1	-0.5	0.4
Lung FEV1/FVC ratio	0.9	4.8	12.0	-0.9	-2.5	-2.2	3.5	-2.4	1.6	1.7	1.6	1.9	2.4	-2.4
Lung FVC	0.7	3.6	8.9	-2.6	-1.2	-1.5	1.1	-1.7	-1.6	-1.5	3.0	2.4	2.3	-0.8
Neuroticism	8.0	19.2	33.5	3.3	3.7	4.9	-3.2	5.8	-4.0	-3.8	-3.4	-4.9	-5.0	5.3
Chronotype (morning person)	0.5	1.2	3.9	2.0	1.7	0.7	-1.4	-0.1	1.0	0.8	-0.9	-1.1	-0.6	-0.0
Hair Pigment	0.0	0.9	7.4	1.2	-0.2	-0.4	-2.7	-0.2	0.4	0.0	-0.3	0.1	-0.4	-0.4
Tanning	0.5	6.1	9.1	-2.9	-3.0	-2.8	1.9	-2.6	1.5	1.9	2.4	2.5	2.8	-2.5
Hand grip strength (left)	0.3	0.9	3.2	1.0	-0.5	-0.4	0.9	-0.5	1.8	1.7	-0.6	0.0	-0.1	-0.9
Number of treatments/medications taken	3.7	6.7	12.9	3.4	2.3	3.5	-0.4	2.6	-1.1	-1.4	-2.8	-3.6	-2.8	2.5
Average weekly spirits intake	2.3	2.8	5.8	-0.8	-1.1	-1.8	0.6	-2.4	1.0	1.2	2.1	2.4	1.6	-2.2
Sensitivity / hurt feelings	1.9	3.2	9.7	1.1	0.8	1.5	-3.1	2.3	-1.6	-1.4	-1.2	-1.9	-1.5	2.1
Frequency of depressed mood in last 2 weeks	2.7	3.7	7.1	1.9	1.5	2.0	-1.9	2.6	-0.5	-0.2	-2.0	-2.7	-2.4	2.0
Hearing difficulty/problems: Yes	0.1	0.2	1.1	0.4	0.0	-0.2	-1.1	0.3	-0.8	-0.5	-0.2	0.2	-0.0	-0.1
Relative age of first facial hair	1.5	3.1	10.5	-1.5	0.9	1.5	-1.2	1.4	-2.9	-3.2	0.2	-0.5	-0.7	2.4
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.0	-0.1	-0.4	-0.7	0.5	-1.2	1.2	1.3	0.1	0.5	1.0	-1.4
Ever used hormone-replacement therapy (HRT)	1.8	2.3	6.8	-0.8	1.0	1.5	-1.3	1.4	-2.5	-2.6	0.5	-0.6	-0.7	2.0
Ever had hysterectomy (womb removed)	0.1	0.1	0.4	-0.2	-0.7	-0.1	-0.5	-0.0	-0.4	-0.5	0.1	0.3	0.2	-0.1
Systolic blood pressure, automated reading	0.1	0.4	2.0	1.4	-0.6	0.3	1.0	0.0	0.1	0.2	-0.0	-0.4	-0.7	-0.1
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.9	0.7	0.9	-0.0	-0.0	-0.7	0.7	0.6	-0.6	0.5	0.1	-0.7
Angina	1.1	1.5	6.7	2.6	0.4	1.2	1.1	0.3	0.9	0.6	-1.9	-1.0	-1.0	0.0
Medication for hormone replacement therapy	0.2	0.2	0.8	-0.1	-0.4	-0.0	0.9	-0.7	0.2	0.2	0.6	-0.0	0.5	-0.3
Vitamin and mineral supplements	3.5	4.8	8.2	0.9	2.0	2.5	-1.5	2.5	-2.6	-2.7	-1.1	-1.7	-2.5	2.9
Supplements: Zinc	0.3	0.3	1.0	-1.0	-1.0	-0.1	-0.7	-0.3	-0.0	0.2	0.5	0.1	0.5	-0.2
Medication: Co-codamol	0.8	0.9	2.1	0.7	1.5	1.1	-0.9	1.0	-0.9	-1.0	-0.8	-0.8	-0.8	1.0
Medication: Metformin	0.5	0.7	2.0	1.4	1.1	0.9	-1.3	0.2	-0.3	-0.4	-0.7	-1.0	-0.7	0.5
Diabetes (father)	0.5	0.6	1.7	-0.6	-1.3	-0.6	0.1	-0.5	0.9	1.1	0.5	0.2	0.8	-0.8
Diabetes (mother)	0.4	0.6	1.4	0.2	0.9	0.3	-0.1	0.7	-0.9	-1.2	-0.7	-0.4	-0.8	1.1
Severe depression (siblings)	1.1	1.2	4.6	0.9	0.6	-0.7	-0.4	-1.1	2.1	1.8	-0.8	0.1	0.3	-1.2
Pack years adult smoking proportion	2.9	4.4	8.6	2.2	2.0	2.3	-2.2	2.5	-0.4	-0.4	-2.9	-2.3	-2.5	1.9
Impedance of leg (right)	0.8	3.8	9.6	-1.8	-0.2	1.1	-1.2	2.8	-3.1	-3.0	0.0	-0.4	-1.2	2.8
Leg fat-free mass (left)	0.9	4.9	16.6	2.3	0.1	-1.0	0.6	-2.6	4.1	3.8	-0.7	0.1	0.8	-2.9
Trunk fat percentage	0.3	1.4	4.2	2.1	0.4	1.0	-0.3	0.1	1.6	1.4	-1.7	-1.2	-0.8	-0.1
Hand grip strength (right)	0.2	0.5	1.3	1.0	0.2	0.4	0.5	0.7	0.6	0.4	-1.2	-0.9	-1.0	0.5
Townsend deprivation index at recruitment	2.0	2.8	9.0	1.8	-0.3	-0.4	-3.0	-0.3	2.7	2.5	-1.8	-0.1	-0.5	-1.1
Current tobacco smoking	0.7	1.1	2.2	-0.8	-0.9	-1.0	1.1	-1.5	0.9	0.7	0.7	0.8	1.5	-1.3
Average weekly fortified wine intake	1.4	1.6	3.1	-1.2	-0.5	-1.3	1.5	-1.6	0.2	0.2	1.8	1.6	1.6	-1.3
Maternal smoking around birth	1.5	2.2	4.1	1.1	1.2	1.1	-2.0	2.0	-0.7	-0.7	-1.6	-1.7	-1.6	1.9
Fed-up feelings	2.4	4.3	7.3	1.8	2.1	2.2	-2.7	2.5	-1.3	-1.1	-2.1	-2.3	-2.1	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	4.9	9.0	2.5	1.8	2.8	-1.8	2.5	-0.5	-0.7	-2.5	-3.0	-2.6	2.2
Relative age voice broke	1.7	2.7	8.0	-0.9	1.5	1.2	-0.9	1.5	-2.8	-2.7	0.7	-0.2	-1.1	2.1
Taking other prescription medications	2.8	4.4	8.4	2.2	2.3	2.9	-0.7	2.1	-1.1	-1.4	-2.1	-2.7	-2.3	2.1
Age when periods started (menarche)	0.8	1.8	7.4	-0.5	0.2	0.4	1.4	0.8	-2.7	-2.1	1.8	-0.0	-0.2	1.5
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	0.8	-0.1	0.3	0.7	-0.9	0.8	-0.2	-0.4	-0.1	-0.5	-0.5	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.7	0.4	0.3	0.9	1.3	0.7	-1.2	-0.8	0.1	-1.0	-0.6	0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.9	0.4	0.1	0.4	-0.1	0.7	1.6	1.7	-1.5	-0.9	-0.7	-0.1
Qualifications: CSEs or equivalent	0.1	0.2	0.6	0.3	0.2	0.0	-0.7	0.8	0.0	0.0	-0.3	-0.3	-0.7	0.3
Serious illness, injury or assault to yourself	0.2	0.3	0.9	0.5	0.6	-0.1	0.7	-0.5	0.6	0.9	-0.2	-0.1	0.3	-0.7
High blood pressure	0.6	1.7	3.3	1.7	0.2	1.8	-0.4	1.3	-1.3	-1.4	-0.3	-1.6	-1.4	1.4
Hayfever, allergic rhinitis or eczema	0.5	1.0	3.2	1.8	1.2	0.7	-0.1	0.4	0.9	1.0	-1.3	-1.2	-0.8	-0.2
Multivitamins +/- minerals	3.1	3.9	6.2	-0.7	-2.4	-2.4	1.9	-1.9	2.5	2.5	0.5	1.4	1.9	-2.4
Stomach or abdominal pain in last month	3.1	3.9	5.8	2.1	2.0	2.2	-1.2	2.4	-1.1	-1.1	-2.4	-2.2	-2.1	2.1
Supplements: Glucosamine	1.9	2.5	7.7	-1.0	-0.9	-2.0	2.8	-1.3	0.9	1.4	1.1	1.4	1.6	-1.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	0.9	0.1	-0.0	0.8	-0.3	0.8	1.0	-0.7	0.0	-0.2	-0.6
Medication: Atenolol	0.7	0.9	6.8	0.2	0.8	0.6	2.6	0.2	-0.7	-0.6	0.2	-0.9	0.0	0.6
Medication: Levothyroxine sodium	0.4	0.7	2.5	-0.3	-1.6	-0.6	0.9	-0.2	1.3	1.2	-0.4	0.5	0.2	-0.5
Sitting height	0.3	2.2	7.3	0.3	-0.9	-0.8	-0.2	-1.8	2.7	2.5	0.1	0.6	1.1	-2.1
Chronic bronchitis/emphysema (father)	2.2	2.6	6.9	1.8	1.6	1.4	0.1	1.6	0.5	0.2	-2.6	-2.1	-2.3	1.1
High blood pressure (mother)	0.6	0.9	2.0	1.3	0.7	0.8	0.6	-0.1	1.4	1.2	-1.3	-1.1	-0.4	-0.3
Body mass index (BMI)	1.1	4.7	16.4	4.1	2.2	1.9	-0.1	1.1	1.5	1.3	-3.0	-2.5	-2.4	0.6
Impedance of leg (left)	0.6	2.9	7.1	-2.1	-0.5	0.8	-1.1	2.3	-2.7	-2.6	0.1	-0.1	-0.8	2.4
Leg predicted mass (left)	0.9	4.9	16.9	2.4	0.1	-0.9	0.4	-2.5	4.1	3.9	-0.9	-0.0	0.7	-2.8
Trunk fat mass	0.5	2.1	6.2	2.4	0.3	0.7	-0.2	-0.5	2.5	2.3	-1.8	-1.1	-0.6	-0.8
Waist circumference	1.0	3.8	11.7	3.4	1.3	1.4	-0.1	0.7	2.3	1.9	-3.1	-2.0	-1.9	0.0
Number of incorrect matches in round	2.8	4.7	12.0	-2.4	-1.8	-2.0	1.8	-2.4	-0.5	-0.5	3.5	2.7	2.7	-1.6
Past tobacco smoking	1.1	2.0	5.3	2.0	2.3	1.3	-1.0	0.8	0.9	0.7	-2.0	-1.5	-1.4	0.4
Alcohol usually taken with meals	0.5	0.8	1.5	-1.2	-1.0	-0.9	0.1	-1.1	0.8	0.4	1.0	0.6	1.1	-1.0
Nervous feelings	7.2	13.4	23.4	3.7	3.4	3.8	-2.2	4.8	-1.9	-2.1	-3.4	-4.4	-4.8	4.1
Frequency of tenseness / restlessness in last 2 weeks	4.4	6.9	12.2	2.6	2.6	2.8	-1.9	3.4	-1.7	-1.6	-1.9	-3.5	-3.2	3.0
Hearing difficulty/problems with background noise	1.2	1.9	3.4	-1.0	-1.6	-1.8	-0.4	-1.4	0.3	1.0	1.3	1.7	1.7	-1.8
Hair/balding pattern: Pattern 2	1.6	2.0	5.5	0.5	2.4	1.9	-1.6	1.7	-0.7	-0.8	-1.1	-1.4	-1.2	1.4
Had menopause	0.6	0.8	3.0	-0.8	0.2	-0.2	0.0	-0.1	-1.7	-1.6	1.0	0.8	0.4	0.6
Had other major operations	0.2	0.3	0.8	-0.0	0.5	-0.3	-0.9	-0.9	0.2	0.1	0.2	0.9	0.2	-0.6
Forced vital capacity (FVC)	0.5	1.9	3.7	-1.9	-1.9	-1.3	0.1	-1.3	0.3	0.5	1.4	1.6	1.9	-1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.8	0.1	-0.9	0.1	0.9	0.1	0.0	0.5	-0.1	-0.4	-0.2	0.1
Ever unenthusiastic/disinterested for a whole week	2.7	3.3	11.3	1.8	0.9	1.2	-2.1	2.0	1.4	1.2	-3.4	-1.7	-2.1	1.0
Qualifications: None of the above	0.4	0.8	3.2	0.2	0.6	0.5	0.5	0.0	1.8	1.0	-1.8	-0.6	-0.2	-0.1
Financial difficulties in last 2 years	0.9	1.3	3.8	1.9	0.2	0.7	-1.4	0.7	0.9	1.1	-1.9	-0.9	-1.0	-0.0
Mouth/teeth dental problems	1.6	2.5	3.9	-1.3	-1.3	-1.8	2.0	-1.9	1.3	1.2	1.4	1.6	1.7	-1.6
Heart attack	2.0	2.6	5.7	2.1	0.7	2.4	0.2	1.4	0.5	0.1	-2.3	-2.4	-1.7	1.3
Allergy	0.8	1.9	5.2	-2.3	-1.2	-0.8	0.4	-0.3	-1.7	-1.8	1.9	1.5	0.9	0.5
Pain all over the body in last month	1.6	1.8	6.6	1.0	0.6	-0.3	-1.4	-0.6	2.5	2.6	-1.1	-0.5	0.1	-1.2
Diabetes (self-reported)	0.2	0.3	0.8	0.8	0.2	0.9	-0.5	0.0	-0.3	-0.5	-0.7	-0.4	-0.2	0.3
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	5.2	2.3	1.6	1.5	-0.2	1.1	1.1	0.8	-2.3	-2.1	-2.0	0.6
Medication: Ramipril	0.2	0.2	0.6	-0.8	-0.6	-0.1	0.4	-0.5	-0.3	-0.6	0.5	0.3	0.5	-0.2
Medication: Simvastatin	0.6	0.9	3.3	0.4	-0.6	-0.7	1.8	-1.0	1.2	1.0	-0.1	-0.1	0.7	-1.2
Fluid intelligence score	0.9	1.8	7.2	1.0	1.1	1.1	-2.7	1.2	-0.3	-0.5	-1.5	-1.3	-1.6	1.1
Illnesses of siblings	0.4	0.5	2.2	0.5	-0.2	-0.5	-0.4	-0.5	1.3	1.5	-0.0	0.3	0.2	-0.8
Neuroticism score	5.8	12.1	21.0	2.6	2.2	3.7	-3.7	4.6	-2.9	-2.8	-2.8	-3.9	-4.1	4.2
Weight	0.7	3.5	10.6	3.1	0.8	0.4	0.3	-0.8	3.3	3.0	-2.0	-1.1	-0.7	-1.3
Impedance of arm (right)	0.3	1.5	6.9	-2.6	-1.6	-0.5	0.1	-0.1	-1.2	-1.1	1.4	0.8	1.3	0.3
Arm fat percentage (right)	1.0	3.9	12.8	3.6	1.8	2.0	-0.0	1.0	1.4	1.1	-2.8	-2.5	-2.1	0.7
Trunk fat-free mass	0.7	4.0	12.8	1.6	-0.2	-1.2	0.6	-2.3	3.6	3.5	-0.3	0.5	0.8	-2.7
Hip circumference	0.7	3.1	9.1	3.0	1.4	1.0	-0.5	0.0	2.6	2.3	-2.3	-1.4	-1.2	-0.5
Time employed in main current job	0.9	1.0	2.2	-0.1	-0.6	-0.9	0.8	-1.5	1.2	1.3	0.8	0.7	1.2	-1.2
Alcohol intake versus 10 years previously	0.4	0.6	2.0	1.4	-0.1	0.8	-0.6	0.5	-0.4	-0.4	-0.9	-0.9	-0.8	0.7
Father’s age at death	1.1	1.5	5.3	-2.3	-0.8	-0.8	1.3	-1.2	0.1	-0.2	1.6	1.4	1.4	-0.7
Worrier / anxious feelings	4.0	7.6	12.3	2.4	1.6	3.0	-2.9	3.5	-1.6	-2.0	-2.9	-3.1	-3.3	3.2
Frequency of tiredness / lethargy in last 2 weeks	3.3	5.4	9.7	1.6	2.2	2.4	-2.2	3.1	-1.1	-1.4	-2.6	-2.5	-2.8	2.7
Falls in the last year	0.2	0.3	2.5	0.5	0.5	0.2	-1.6	0.1	0.4	0.3	-0.1	-0.3	-0.5	0.1
Hair/balding pattern: Pattern 3	0.5	0.7	2.1	0.4	-0.6	-1.0	0.7	-1.4	0.5	0.5	0.6	0.7	1.0	-1.1
Number of live births	0.2	0.3	1.8	-0.1	-1.3	0.1	-0.1	0.3	0.8	0.3	-0.7	-0.0	-0.0	-0.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.5	6.2	-1.9	-2.5	-1.6	1.0	-1.4	0.8	1.1	1.3	1.7	2.0	-1.4
Pulse rate	0.5	0.9	1.4	0.5	1.1	1.2	0.5	1.1	-0.9	-1.2	-0.6	-1.0	-1.1	1.1
Happiness	2.0	2.5	5.1	2.0	2.2	1.7	-1.3	1.5	-0.3	-0.4	-1.9	-1.8	-1.6	1.2
Noisy workplace	0.4	0.5	2.6	0.3	-0.3	0.7	1.6	0.8	-0.6	-0.5	-0.3	-0.5	-0.4	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.4	-0.7	-0.6	-0.0	-1.2	0.1	-1.0	-0.8	0.8	0.3	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.5	2.5	-1.2	-1.6	-0.4	-0.9	0.0	0.1	0.1	0.8	0.3	0.5	-0.0
Mouth/teeth dental problems: Dentures	1.2	2.0	6.7	1.4	2.6	1.6	-0.4	1.1	-1.8	-1.4	-0.6	-0.8	-1.1	1.3
Asthma	0.6	1.2	2.5	1.6	1.4	0.7	-0.9	0.6	0.8	0.9	-1.5	-1.4	-1.2	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.1	5.9	-0.7	-2.4	-0.7	-0.2	-1.1	0.7	0.6	0.3	1.0	1.0	-1.0
Medication: Cholesterol lowering	0.6	1.0	5.6	0.8	-0.3	-0.0	2.4	-0.4	1.4	1.1	-0.6	-0.4	0.2	-0.8
Depression (self-reported)	5.8	6.9	11.4	3.0	2.4	3.2	-1.5	3.2	-0.9	-1.0	-2.7	-3.1	-3.4	2.8
Medication: Lansoprazole	2.7	3.0	6.2	-0.1	1.4	2.3	0.6	2.1	-2.2	-2.5	-1.4	-1.3	-1.1	2.3
Prospective memory result	0.2	0.3	2.0	-1.4	-0.4	0.1	0.5	-0.2	-0.1	-0.1	0.2	-0.0	0.7	0.0
Lung cancer (father)	0.4	0.5	3.1	0.5	0.1	0.1	-1.7	0.6	-0.0	-0.1	-0.3	-0.5	-0.9	0.5
Illnesses of mother	0.3	0.4	1.2	-0.9	-1.1	-0.7	0.2	-0.4	0.3	0.4	0.6	0.8	0.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	3.8	-1.8	-1.9	-1.6	0.2	-1.6	0.2	0.4	1.8	1.9	1.9	-1.3
Pulse wave Arterial Stiffness index	0.4	0.5	1.2	0.5	0.4	0.6	-1.1	0.6	-1.1	-0.8	0.0	-0.6	-0.5	0.7
Impedance of arm (left)	0.6	2.9	11.3	-3.4	-2.2	-1.1	-0.2	-0.6	-1.4	-1.2	2.2	1.6	1.8	-0.1
Arm fat mass (right)	0.8	3.4	11.8	3.4	1.7	1.3	-0.1	0.2	2.2	2.0	-2.5	-2.0	-1.5	-0.2
Trunk predicted mass	0.7	3.9	12.4	1.7	-0.2	-1.2	0.5	-2.3	3.5	3.5	-0.2	0.5	0.8	-2.7
Standing height	1.1	10.9	19.0	-2.0	-2.9	-3.5	0.8	-4.3	3.9	3.9	2.3	3.0	3.7	-4.4
Length of working week for main job	1.3	1.5	3.1	1.3	1.1	1.8	-0.6	1.2	-0.5	-0.6	-1.4	-1.6	-1.2	1.4
Exposure to tobacco smoke at home	0.2	0.3	0.7	-0.5	0.5	-0.1	-0.8	-0.4	-0.5	-0.3	0.4	0.8	0.5	-0.1
Breastfed as a baby	0.4	0.5	1.2	-0.1	0.7	0.5	0.7	0.9	-0.6	-0.7	-0.4	-0.6	-0.8	1.1
Tense / ‘highly strung’	2.4	3.9	7.0	1.2	1.9	1.7	-2.0	2.6	-2.2	-1.9	-0.4	-1.9	-2.4	2.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	2.4	1.0	0.1	1.3	-1.5	1.4	-1.4	-1.1	-0.9	-1.2	-1.2	1.5
Hair/balding pattern: Pattern 4	0.2	0.4	1.6	-0.1	0.3	-0.6	1.3	-0.5	0.7	0.8	0.4	0.3	0.2	-0.7
Birth weight of first child	0.2	0.4	1.0	0.4	-0.1	-0.4	0.9	-0.9	0.1	0.4	0.7	1.0	0.3	-0.7
Peak expiratory flow (PEF)	0.2	0.4	1.4	0.0	-1.2	-0.1	0.3	0.9	0.6	0.7	-1.1	-0.3	-0.4	0.4
Pulse wave reflection index	0.5	0.6	1.7	-0.8	-1.3	-0.5	-0.3	-0.2	-1.3	-0.8	1.0	0.4	0.6	0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	0.6	0.3	1.0	0.2	1.2	-0.1	0.0	-1.6	-0.9	-1.1	0.7
Loud music exposure frequency	0.3	0.3	1.2	-0.0	-0.5	-0.4	-0.5	-0.7	1.1	0.7	-0.0	0.2	0.4	-0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	4.8	0.4	0.2	0.3	-2.2	1.0	-0.5	-0.1	-0.2	-0.3	-0.9	0.5
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.0	-0.7	-1.4	-0.9	0.5	-0.8	0.8	1.0	0.8	0.4	0.8	-1.0
Blood clot in the leg (DVT)	0.5	0.6	1.5	-0.1	-1.2	-0.7	0.9	-0.7	1.0	1.2	0.2	0.4	0.6	-0.9
Medication: Paracetamol	1.5	2.5	4.8	0.6	2.2	1.7	-1.4	1.6	-1.9	-2.0	-0.5	-1.4	-1.2	2.0
Headache pain in last month	0.9	1.6	2.9	1.1	1.4	1.3	-0.8	1.7	-1.0	-0.7	-1.1	-1.4	-1.7	1.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.1	-1.3	-0.3	-0.6	-1.4	0.2	0.1	0.0	0.0	0.8	-0.1	0.3
Glaucoma (self-reported)	0.4	0.5	1.8	-0.2	1.0	-0.2	-1.3	-0.1	1.1	1.1	-0.2	-0.2	0.1	-0.5
Gout (self-reported)	1.1	1.5	4.3	-0.8	-0.3	-0.9	2.0	-0.9	2.1	1.9	-0.1	0.3	0.9	-1.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.5	-1.1	-1.6	-1.2	0.6	-0.8	1.4	1.6	0.4	1.1	1.1	-1.1
Medication: Amlodipine	0.8	1.1	2.1	1.3	-0.5	1.2	-0.5	1.3	0.0	0.0	-1.4	-1.4	-1.1	1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.6	1.3	0.9	0.2	1.3	0.0	-0.0	0.2	-0.4	-0.7	-0.6	0.1
Birth weight	0.7	1.5	3.4	1.2	1.2	1.1	1.1	0.8	1.4	0.8	-1.8	-1.6	-1.1	0.6
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.6	0.3	-0.4	-0.4	-0.0	0.1	0.8	0.7	-0.2	-0.0	-0.1	-0.0
High blood pressure (siblings)	0.4	0.6	1.3	-0.5	-1.2	-0.9	0.8	-0.9	0.1	0.3	0.5	0.9	0.9	-1.0
Forced vital capacity (FVC), Best measure	0.9	3.4	6.1	-2.3	-1.9	-1.9	-0.1	-2.1	0.3	0.5	2.2	2.4	2.5	-1.7
Body fat percentage	0.8	3.0	8.3	2.9	1.3	1.8	-0.4	1.1	1.2	1.0	-2.7	-2.1	-1.9	0.8
Leg fat percentage (right)	2.3	8.2	16.1	4.0	2.7	3.3	-0.5	2.9	0.0	-0.4	-3.8	-3.5	-3.7	2.4
Arm fat-free mass (right)	0.6	3.3	11.0	2.0	0.2	-0.9	-0.1	-1.9	3.3	3.2	-0.6	0.4	0.5	-2.4
Exposure to tobacco smoke outside home	0.2	0.3	1.6	1.3	0.0	0.5	-0.9	-0.1	-0.6	-0.3	-0.1	-0.1	-0.2	0.2
Comparative body size at age 10	0.8	2.2	7.8	0.3	-1.2	-0.9	1.0	-1.3	2.8	2.6	-0.8	0.7	0.2	-1.8
Number of full brothers	1.0	1.3	4.6	1.6	1.0	1.0	-0.5	1.0	0.5	0.3	-2.1	-1.0	-1.5	0.7
Worry too long after embarrassment	3.3	5.5	11.4	1.4	1.3	2.5	-3.4	2.9	-1.7	-2.1	-2.0	-2.3	-2.7	2.8
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	3.1	1.5	0.4	1.0	-1.8	1.4	-0.2	-0.1	-1.0	-1.3	-1.6	1.1
Wheeze or whistling in the chest in last year	1.8	3.3	5.7	2.4	2.3	1.8	-1.4	1.6	0.4	-0.0	-2.4	-2.3	-2.0	1.4
Number of children fathered	0.1	0.1	0.6	-0.7	0.1	0.2	-0.5	0.2	0.0	0.4	0.2	-0.3	0.3	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.6	0.6	-0.1	-0.6	-0.4	-0.8	0.8	0.3	0.5	-0.1	0.3	-0.7
Age at first live birth	1.5	2.6	8.1	-2.8	-0.4	-0.9	1.0	-0.9	-1.8	-1.6	2.6	1.5	1.7	-0.2
Pulse wave peak to peak time	0.6	0.6	1.9	-0.5	-0.5	-0.7	1.0	-0.7	1.4	1.1	-0.0	0.7	0.6	-0.9
Health satisfaction	3.3	4.3	7.2	2.7	2.7	2.6	-1.4	1.9	-0.7	-0.6	-2.6	-2.4	-2.1	1.7
Shortness of breath walking on level ground	0.9	1.1	2.6	0.8	0.4	1.0	-1.6	1.3	-0.7	-0.5	-1.0	-1.0	-1.3	1.1
Qualifications: College or University degree	0.8	2.6	10.4	-1.8	-0.2	-0.0	-1.1	-0.1	-3.2	-2.4	2.6	0.7	0.8	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.4	0.5	0.2	0.0	0.7	0.2	0.4	0.3	-0.5	-0.4	-0.2	-0.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	3.1	0.5	0.8	1.1	-0.5	1.8	-0.1	-0.5	-1.2	-1.3	-1.3	1.1
Emphysema/chronic bronchitis	0.2	0.2	0.6	0.4	0.3	-0.0	-0.4	-0.5	0.4	0.6	-0.4	0.3	0.2	-0.8
Medication for pain relief, constipation, heartburn	2.3	3.9	6.5	-2.0	-2.2	-2.6	0.9	-2.2	1.0	1.2	2.0	2.6	2.3	-2.0
Neck or shoulder pain in last month	0.6	0.8	1.6	1.3	0.4	0.7	0.5	1.2	-0.1	-0.2	-1.2	-1.1	-1.2	0.7
Medication: Blood pressure	0.2	0.4	2.1	1.5	0.5	0.8	0.7	-0.0	-0.3	-0.2	0.1	-0.8	-0.1	-0.1
Angina (self-reported)	0.9	1.2	4.7	2.2	-0.0	1.0	1.4	0.1	1.0	0.7	-1.7	-0.8	-0.7	-0.1
Migraine (self-reported)	2.7	3.4	6.0	1.1	1.3	2.0	-1.5	2.2	-1.7	-1.9	-1.8	-1.7	-2.0	2.4
Medication: Ibuprofen	0.6	0.7	3.2	-0.6	-1.8	-0.4	-0.6	-1.1	0.5	0.4	0.3	0.9	0.9	-0.9
Medication: Allopurinol	0.6	0.7	4.2	-1.2	-0.7	-0.6	2.0	-0.3	0.7	0.6	0.3	0.2	0.7	-0.4
Medication: Omeprazole	0.2	0.2	0.5	0.6	0.3	0.4	0.3	0.3	-0.1	-0.3	-0.4	-0.6	-0.7	0.4
Medication: Seretide 50 evohaler	1.0	1.2	2.5	0.4	-0.5	-0.7	-1.2	-1.6	1.5	1.6	0.2	1.1	0.7	-1.4
Mean time to correctly identify matches	1.6	3.0	5.8	-1.7	-2.0	-1.6	0.6	-2.4	0.1	0.1	2.0	2.2	2.2	-1.8
Heart disease (mother)	0.5	0.7	3.1	0.4	0.9	0.4	-0.5	-0.1	-1.8	-1.5	0.6	0.2	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	3.7	0.7	-0.2	-1.1	1.9	-0.5	1.9	1.4	-0.7	-0.3	0.3	-0.9
Whole body fat mass	0.7	2.9	9.4	3.1	1.0	1.2	-0.1	0.2	2.3	2.0	-2.5	-1.7	-1.3	-0.2
Leg fat mass (right)	1.2	4.7	15.8	4.0	1.9	2.0	-0.2	1.1	1.7	1.3	-3.2	-2.5	-2.3	0.6
Arm predicted mass (right)	0.6	3.1	10.9	1.8	0.2	-0.9	-0.2	-1.8	3.3	3.2	-0.6	0.3	0.4	-2.3
Pulse rate, automated reading	0.3	0.9	1.8	-0.3	-1.3	-1.0	1.3	-1.3	0.2	-0.1	1.3	1.0	0.7	-1.0
Alcohol intake frequency.	2.5	5.9	16.1	1.5	1.9	2.4	-4.0	2.9	-0.3	-0.6	-3.2	-2.1	-2.7	2.5
Comparative height size at age 10	2.7	14.9	24.6	-2.1	-4.3	-3.8	2.4	-4.9	4.6	4.3	2.4	2.9	4.3	-5.0
Number of full sisters	0.8	1.0	2.7	1.6	1.0	0.5	-0.7	0.7	0.9	0.5	-1.6	-1.3	-1.1	0.4
Suffer from ‘nerves’	3.3	5.2	9.8	2.0	2.1	2.3	-1.7	3.1	-1.4	-1.6	-1.9	-2.8	-2.8	2.8
Overall health rating	6.6	14.3	27.7	5.3	3.9	4.3	-1.5	3.8	-0.5	-1.1	-5.0	-4.7	-4.5	3.1
Chest pain or discomfort	3.0	4.3	8.1	1.9	1.1	2.2	-2.6	2.6	-0.2	-0.3	-2.9	-2.3	-2.6	2.0
Had major operations	0.8	0.9	2.0	1.2	1.4	1.0	-0.2	0.8	0.7	0.6	-1.2	-1.3	-1.1	0.5
Age at last live birth	0.3	0.4	1.3	-1.2	-0.4	0.3	0.4	0.2	-1.0	-0.9	0.9	-0.0	0.4	0.5
Family relationship satisfaction	0.9	1.1	2.0	1.3	0.9	1.2	-1.4	0.9	0.2	-0.0	-1.4	-1.4	-1.0	1.1
Leg pain on walking	0.6	0.7	2.7	0.0	-1.6	-0.6	0.5	-0.4	1.0	1.3	-0.5	0.6	0.5	-0.8
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	5.7	2.4	1.7	1.6	0.7	1.7	0.1	-0.0	-1.9	-1.7	-2.1	1.3
Commuting to job workplace: Car/motor vehicle	3.1	3.5	6.9	1.6	1.5	2.0	-0.2	2.6	-0.3	-0.7	-2.3	-2.5	-2.5	2.3
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	4.0	-1.7	0.7	-0.1	0.5	-0.1	-1.7	-2.0	1.4	0.6	0.6	0.7
Medication: Aspirin	1.7	2.3	4.6	2.1	1.5	2.0	0.2	1.5	-0.1	-0.6	-2.0	-1.7	-1.9	1.2
Supplements: Vitamin C	0.9	1.1	2.0	0.0	-0.7	-1.3	0.6	-1.3	1.1	1.0	1.1	0.8	1.2	-1.4
Knee pain experienced in last month	0.2	0.3	0.7	0.7	0.5	0.2	0.2	0.7	0.0	-0.2	-0.8	-0.8	-0.7	0.5
Hypertension (Self-reported)	0.5	1.4	3.3	1.8	0.0	1.6	-0.0	1.0	-1.4	-1.4	-0.2	-1.3	-1.2	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.5	2.9	4.9	1.1	1.9	1.8	0.0	2.2	-1.9	-1.7	-1.1	-1.9	-1.7	2.2
Illnesses of father: Heart disease	1.4	2.0	8.5	-0.3	0.0	1.0	0.2	0.8	-2.9	-2.8	0.9	-0.0	-0.4	1.7
Illnesses of siblings: Diabetes	3.6	4.4	7.6	1.8	2.8	2.6	-0.9	2.3	-0.8	-1.3	-2.3	-2.7	-2.3	2.2
Smoking status: Previous	1.0	1.5	4.4	-1.9	-2.1	-1.1	0.7	-0.4	-0.7	-0.6	1.5	1.2	1.3	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.7	-0.2	-0.8	-0.7	-0.2	-1.6	1.2	1.3	0.4	1.0	1.2	-1.4
Whole body fat-free mass	0.8	4.7	16.4	2.1	-0.0	-1.1	0.5	-2.4	4.0	3.9	-0.6	0.3	0.7	-2.9
Leg fat-free mass (right)	1.0	5.1	17.1	2.1	0.0	-1.0	0.5	-2.8	4.1	3.9	-0.7	0.2	1.0	-3.0
Arm fat percentage (left)	0.8	3.0	10.2	3.2	1.4	1.7	-0.2	0.7	1.5	1.2	-2.6	-2.1	-1.7	0.4
Average weekly red wine intake	2.8	4.1	9.0	-2.4	-1.7	-2.3	1.1	-2.3	0.4	0.7	3.0	1.9	2.9	-1.8
Handedness (chirality/laterality): Left-handed	0.7	0.9	2.1	-0.4	0.7	0.0	1.0	-1.3	-1.2	-1.2	1.4	0.7	1.0	-0.4
Mood swings	6.2	11.2	19.4	3.3	3.1	4.0	-1.5	4.3	-1.9	-1.8	-3.3	-4.4	-3.8	3.7
Loneliness, isolation	2.5	3.5	10.5	1.9	0.5	1.4	-3.2	2.3	-0.5	-0.2	-2.2	-1.8	-2.3	1.7
Long-standing illness, disability or infirmity	0.8	1.3	2.6	1.2	1.6	1.3	-0.9	1.0	-0.5	-0.7	-1.2	-1.2	-1.3	0.9
Ever had bowel cancer screening	1.5	1.8	3.4	1.4	1.5	1.7	-0.4	1.7	-0.5	-0.5	-1.4	-1.8	-1.4	1.3
Diabetes diagnosed by doctor	1.0	1.7	3.6	1.7	1.2	1.9	-0.9	1.1	-0.4	-0.7	-1.6	-1.5	-1.2	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.3	0.3	-1.1	-0.4	0.2	-0.6	0.9	0.6	-0.2	0.3	0.4	-0.5
Friendships satisfaction	0.2	0.3	1.0	-0.0	0.9	0.7	-0.4	0.4	0.1	0.0	-0.5	-1.0	-0.2	0.5
Qualifications: nursing, teaching	0.1	0.2	0.6	-0.2	0.1	-0.1	-0.3	-0.3	-0.8	-0.5	0.7	0.4	0.3	-0.2
Commuting to job workplace: Walk	2.8	3.0	5.5	-2.0	-1.7	-2.0	1.1	-1.9	-0.5	0.1	2.4	2.3	2.1	-1.5
Eye problems/disorders: Cataract	0.3	0.4	1.0	-0.3	-0.5	-0.7	0.0	-1.0	0.4	0.3	1.0	0.5	0.7	-0.5
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	4.0	0.2	0.7	1.9	-1.9	1.9	-1.6	-1.9	-1.3	-1.4	-1.4	2.0
Medication for cholesterol	0.4	0.7	1.2	-1.1	0.2	-0.9	-0.4	-0.7	1.0	0.9	0.2	1.1	0.9	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	3.9	1.6	1.9	1.8	-0.7	2.0	-0.7	-1.0	-1.9	-1.7	-2.0	1.5
Back pain experienced in last month	1.7	2.5	4.9	1.6	2.2	1.6	-0.8	2.0	0.0	-0.2	-2.1	-1.8	-1.8	1.5
Mineral and other dietary supplements	5.8	7.8	12.6	1.8	3.5	3.6	-2.8	3.0	-1.6	-2.2	-2.4	-2.9	-2.9	3.3
Breast cancer (self-reported)	0.5	0.6	2.0	-0.9	-1.4	-0.5	0.2	-0.1	-1.1	-0.8	1.3	0.4	-0.0	0.2
Asthma (self-reported)	0.7	1.5	3.0	1.7	1.7	0.9	-0.9	0.9	0.5	0.6	-1.6	-1.5	-1.4	0.6
Osteoporosis (self-reported)	1.7	2.1	4.6	1.1	1.4	1.6	-0.3	2.1	-0.5	-0.8	-1.5	-1.5	-2.1	1.8
Osteoarthritis (self-reported)	0.5	0.7	2.4	0.4	-0.5	-0.4	0.5	-0.6	1.4	1.5	-0.9	-0.1	0.7	-1.1
Medication: Aspirin	1.9	2.4	5.7	2.4	1.4	2.1	0.4	1.4	-0.1	-0.4	-1.9	-1.9	-1.9	1.2
Medication: Gliclazide	0.3	0.3	1.1	-0.2	-0.3	0.3	-1.1	-0.5	-0.8	-0.8	0.5	-0.0	0.3	0.2
Illnesses of father: None of the above (group 1)	1.1	1.4	2.9	-0.8	-0.6	-1.7	-1.1	-1.0	0.9	1.2	1.0	1.6	1.1	-1.4
Smoking status: Current	0.9	1.4	2.7	-0.8	-1.0	-1.2	1.3	-1.6	0.8	0.8	1.1	1.0	1.5	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	5.6	-2.0	-0.7	-1.1	1.0	-1.3	-1.3	-1.3	2.4	1.9	1.7	-0.5
Whole body water mass	0.8	4.7	15.7	2.0	-0.1	-1.2	0.4	-2.5	4.0	3.8	-0.5	0.4	0.8	-2.9
Leg predicted mass (right)	0.9	4.9	16.5	2.1	0.1	-1.0	0.4	-2.7	4.1	3.9	-0.7	0.2	0.9	-2.9
Arm fat mass (left)	0.7	2.9	10.9	3.3	1.5	1.1	-0.1	0.0	2.1	1.9	-2.3	-1.7	-1.3	-0.3
Number of self-reported non-cancer illnesses	5.0	8.7	15.0	3.6	3.0	3.9	-1.8	3.1	-1.8	-1.7	-2.7	-3.6	-3.4	2.9
Average weekly champagne plus white wine intake	0.6	0.8	2.4	-0.6	0.8	-0.1	-1.6	-0.7	-1.2	-1.0	1.5	0.1	0.7	-0.0
Miserableness	4.5	7.8	13.8	2.0	2.2	3.1	-1.8	3.7	-2.3	-2.3	-2.8	-3.3	-3.2	3.3
Guilty feelings	3.5	5.3	14.1	1.1	1.3	2.0	-3.8	2.8	-2.4	-2.4	-1.2	-2.2	-2.2	2.6
Wears glasses or contact lenses	0.4	0.5	1.5	0.6	0.7	0.9	-0.5	-0.2	-1.2	-1.2	0.1	-0.1	0.2	0.3
Ever taken oral contraceptive pill	0.4	0.4	1.4	-0.6	0.3	0.3	-0.5	0.4	-1.1	-1.2	0.5	-0.2	0.2	0.9
Hearing aid user	0.4	0.5	0.9	-0.5	0.8	-0.3	-0.7	-0.4	-1.0	-0.9	0.9	0.8	0.6	-0.2
Mother’s age at death	0.3	0.4	1.2	-0.1	0.5	-0.5	-0.8	-0.3	-0.7	-0.8	1.1	0.7	0.1	-0.2
Financial situation satisfaction	1.3	1.6	3.4	-0.2	-0.9	-1.3	1.3	-1.2	1.8	1.7	-0.2	1.0	1.4	-1.8
Tinnitus: Yes, now most or all of the time	2.2	2.6	4.5	-1.5	-2.1	-2.1	0.5	-1.7	0.3	0.5	2.0	2.1	1.7	-1.7
Commuting to job workplace: Public transport	0.9	1.1	1.9	-0.6	-1.2	-1.1	-0.9	-1.4	0.5	0.4	1.1	1.2	1.3	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	4.1	0.4	1.4	0.5	-2.0	0.6	0.4	0.3	-0.7	-0.9	-0.6	0.3
Medication: Blood pressure	0.3	0.5	1.1	0.9	-0.8	0.5	0.8	0.5	-0.9	-1.1	-0.1	-0.6	-0.8	0.6
Pain type(s) experienced in last month: Hip pain	1.1	1.4	5.7	1.7	-0.2	0.6	0.1	0.7	1.7	1.4	-2.4	-0.7	-1.0	-0.0
Supplements: Fish oil (including cod liver oil)	3.9	5.1	10.2	-1.6	-3.2	-2.9	1.9	-2.4	1.5	1.8	1.9	2.3	2.3	-2.5
High cholesterol (Self-reported)	0.4	0.7	1.3	1.1	0.6	1.0	1.1	1.0	-0.4	-0.1	-0.7	-1.1	-0.9	0.8
Medication: Bendroflumethiazide	0.3	0.5	2.5	1.6	-0.2	0.9	0.9	0.0	0.5	0.3	-0.6	-0.7	-0.6	-0.0
Medication: Paracetamol	0.7	1.1	2.1	0.6	1.5	1.1	-1.1	1.0	-1.2	-1.3	-0.4	-1.0	-0.7	1.2
Medication: Lisinopril	0.6	0.8	2.1	0.6	0.4	1.2	0.3	0.8	-1.3	-1.5	0.0	-0.9	-0.7	1.0
Medication: Atorvastatin	1.3	1.7	3.2	1.3	0.6	1.8	0.3	1.8	-0.0	0.1	-1.7	-1.6	-1.7	1.2
Illnesses of father: High blood pressure	0.1	0.1	0.7	-0.3	0.3	0.3	0.4	-0.1	-0.2	-0.1	0.8	-0.2	0.4	0.0
Alcohol drinker status: Never	0.2	0.2	0.5	-0.7	0.6	0.5	-0.5	0.4	-0.4	-0.4	0.0	0.0	0.1	0.6
Ever smoked	2.5	4.3	9.3	-3.1	-2.8	-2.1	1.2	-1.8	-0.7	-0.5	2.8	2.5	2.4	-1.2
Basal metabolic rate	0.8	4.2	15.0	2.4	0.3	-0.7	0.4	-2.0	3.9	3.7	-1.0	-0.1	0.3	-2.5
Leg fat percentage (left)	1.8	6.5	14.2	3.8	2.4	2.9	-0.3	2.4	0.5	0.1	-3.6	-3.1	-3.2	1.9
Arm fat-free mass (left)	0.7	3.6	12.2	2.5	0.5	-0.7	-0.1	-1.7	3.5	3.5	-0.9	-0.0	0.1	-2.2
Number of operations (self-reported)	0.7	1.1	3.0	1.1	1.5	1.3	-1.7	0.6	-0.2	-0.6	-0.9	-0.6	-1.0	0.7
Average weekly beer plus cider intake	0.2	0.3	1.6	-0.7	-1.3	0.0	0.4	0.6	-0.3	-0.3	-0.0	0.1	-0.1	0.7
Irritability	0.3	0.6	1.5	0.7	-0.3	0.7	0.1	1.0	-0.9	-0.4	-0.1	-1.2	-0.8	1.0
Risk taking	1.7	2.5	3.9	-0.9	-1.6	-1.6	1.8	-2.0	1.2	1.8	1.0	1.1	1.9	-1.9
Ever had prostate specific antigen (PSA) test	1.6	1.9	3.7	1.2	1.9	1.7	0.5	1.2	-1.4	-1.2	-0.5	-1.9	-1.3	1.5
Fractured/broken bones in last 5 years	0.2	0.3	1.2	-0.5	-0.2	-0.9	0.0	-0.3	0.0	0.4	1.1	0.5	0.2	-0.3
Age started oral contraceptive pill	1.9	2.4	6.9	-1.9	-1.4	-1.7	0.9	-0.8	-1.7	-1.3	2.6	1.7	1.3	-0.3
Diastolic blood pressure, automated reading	0.1	0.4	1.7	0.8	-1.3	-0.4	1.2	-0.5	0.2	0.2	0.6	0.4	-0.3	-0.3
Ever depressed for a whole week	1.1	1.4	4.3	0.9	-0.0	-0.3	-2.1	0.0	1.9	1.8	-1.7	-0.2	-0.3	-0.6
Unable to work because of sickness or disability	0.5	0.6	2.5	0.6	1.6	0.9	-1.2	0.1	-0.6	-0.3	-0.0	-0.6	-0.5	0.6
Commuting to job workplace: Cycle	2.6	3.2	5.0	-2.0	-1.6	-2.2	1.2	-1.9	0.9	1.1	1.8	1.9	2.2	-2.1
Myopia	1.7	2.4	4.8	-0.5	-1.9	-1.6	0.7	-2.2	1.2	0.9	1.8	1.5	1.9	-1.9
Vascular/heart problems diagnosed by doctor	0.7	2.0	3.9	-2.0	-0.1	-1.9	0.4	-1.4	1.3	1.5	0.6	1.7	1.6	-1.5
Cholesterol lowering medication	1.1	1.7	2.9	1.7	1.3	1.5	-0.2	1.4	-0.5	-0.8	-1.4	-1.6	-1.6	1.3
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	1.8	1.4	1.1	1.2	-0.2	0.8	-0.4	-0.9	-0.9	-1.2	-1.2	0.9
Pain experienced in last month	2.0	3.4	7.3	-2.7	-1.7	-1.6	1.7	-1.9	-0.1	-0.1	2.4	2.2	2.3	-1.4
Supplements: Calcium	0.3	0.3	1.1	1.0	0.5	-0.1	0.2	-0.3	0.9	0.7	-0.2	-0.2	-0.2	-0.6
Basal cell carcinoma (self-reported)	3.2	3.8	8.0	0.6	1.5	2.1	-1.5	2.6	-2.1	-2.2	-1.3	-1.7	-1.9	2.8
Heart attack/myocardial infarction (self-reported)	1.9	2.5	5.7	1.8	0.8	2.4	0.4	1.6	0.2	-0.1	-2.2	-2.4	-1.6	1.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.3	-0.6	-1.4	-1.0	0.8	-1.1	1.3	1.5	0.6	0.9	1.1	-1.4
Heart disease (siblings)	0.5	0.7	2.0	-0.8	-0.3	0.4	0.6	1.0	-1.1	-1.4	0.0	-0.2	-0.7	1.2
Alcohol drinker status: Previous	3.4	3.9	6.0	1.0	1.2	2.4	-2.4	2.2	-1.8	-2.1	-1.6	-1.9	-2.0	2.4
Pack years of smoking	2.4	3.6	6.2	1.9	1.9	2.1	-1.8	2.2	-0.6	-0.6	-2.5	-2.0	-2.3	1.8
Impedance of whole body	0.4	2.2	9.1	-3.0	-1.5	-0.2	-1.1	0.8	-1.9	-1.8	1.3	0.9	0.7	1.1
Leg fat mass (left)	1.2	4.5	15.2	3.9	1.9	1.9	-0.3	0.9	1.9	1.5	-3.2	-2.4	-2.2	0.5
Arm predicted mass (left)	0.7	3.5	11.6	2.7	0.6	-0.6	0.1	-1.5	3.4	3.4	-1.1	-0.2	-0.1	-2.1