Hub : Genes

SNCA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0670 0.0250 1.7e-04 0.032 0.030 0.030 0.031 0.036 8.0e-05 1.1e-04 1.4e-04 1.1e-04 2.6e-05
2 GTEx Artery Aorta 0.0890 0.0370 3.8e-03 -0.005 NA 0.015 NA -0.005 7.5e-01 NA 4.9e-02 NA 7.8e-01
3 GTEx Artery Tibial 0.0562 0.0261 7.5e-03 0.048 NA 0.027 NA 0.035 1.2e-04 NA 3.3e-03 NA 9.0e-04
4 GTEx Brain Caudate basal ganglia 0.2290 0.0870 4.1e-03 -0.006 NA -0.007 NA -0.004 5.2e-01 NA 6.0e-01 NA 4.2e-01
5 GTEx Heart Left Ventricle 0.1636 0.0567 3.7e-05 0.152 NA 0.109 NA 0.142 1.8e-08 NA 2.2e-06 NA 5.3e-08
6 NTR Blood 0.0376 0.0112 2.5e-06 0.033 0.024 0.028 0.028 0.030 8.2e-11 2.0e-08 1.3e-09 1.3e-09 3.7e-10
7 YFS Blood 0.0749 0.0162 2.2e-16 0.076 0.057 0.070 0.070 0.073 1.4e-23 5.9e-18 4.9e-22 8.8e-22 1.2e-22
8 TCGA Bladder Urothelial Carcinoma 0.0360 0.0210 6.0e-03 0.008 0.026 0.004 NA 0.006 6.4e-02 2.6e-03 1.4e-01 NA 9.7e-02
9 TCGA Breast Invasive Carcinoma 0.0455 0.0177 6.9e-11 0.036 0.048 0.053 NA 0.051 5.4e-08 3.8e-10 4.1e-11 NA 1.2e-10
10 TCGA Lung Adenocarcinoma 0.0509 0.0247 2.6e-05 0.052 0.042 0.036 NA 0.040 9.4e-07 1.1e-05 4.1e-05 NA 1.6e-05
11 TCGA Prostate Adenocarcinoma 0.1554 0.0466 1.1e-16 0.162 0.149 0.168 NA 0.159 1.1e-16 2.6e-15 3.0e-17 NA 2.3e-16

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.7 1.2 3.5 -1.4 -0.5 -0.7 1.2 -1.1 -0.5 0.3 1.9 1.2 1.3 -0.7
Bipolar Disorder or Schizophrenia 1.1 2.6 6.3 -2.5 -1.2 -1.3 2.1 -1.5 -0.3 0.4 2.3 1.4 2.1 -1.0
Depressed Affect (Nagel 2018) 6.3 13.2 24.8 3.0 3.3 4.2 -1.9 5.0 -2.8 -2.5 -3.5 -4.1 -4.2 4.3
Depression (Nagel 2018) 6.8 10.2 18.8 2.6 2.8 3.7 -1.8 4.3 -1.8 -1.8 -2.9 -4.0 -4.0 3.9
Intelligence (Savage-Jansen 2018) 1.1 3.3 6.0 0.6 1.2 1.7 -2.4 2.0 -2.0 -2.2 -1.0 -1.5 -2.0 2.2
Neuroticism (Nagel 2018) 7.9 18.6 32.1 3.7 3.4 4.8 -3.3 5.7 -3.5 -3.3 -3.7 -4.9 -5.1 5.1
Schizophrenia (2018) 0.8 1.6 4.4 -2.1 -1.2 -1.1 1.8 -1.0 0.1 0.3 1.4 0.8 1.6 -0.7
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 1.0 0.8 0.4 -0.2 0.5 -0.2 -0.7 -0.7 -0.8 -0.7 0.8
Worry (Nagel 2018) 10.2 21.5 36.7 3.7 4.3 5.0 -3.3 6.1 -3.9 -3.9 -3.6 -5.0 -5.5 5.6
Alzheimer’s Disease (in mother) 0.1 0.1 1.2 0.2 -1.1 -0.2 -0.1 -0.2 -0.1 -0.2 -0.0 0.3 0.1 -0.1
Alzheimer’s Disease (in father) 1.3 1.4 3.8 1.1 1.3 1.0 0.0 1.3 0.1 -0.2 -1.5 -2.0 -1.4 1.3
Alzheimer’s Disease (including proxy) 0.9 1.4 3.4 1.7 0.6 0.7 0.2 1.3 0.4 0.1 -1.9 -1.7 -1.4 1.1
Crohns Disease (2017) 0.7 1.4 4.9 0.9 2.2 1.2 -1.3 0.9 -0.9 -1.3 -0.6 -1.2 -1.0 1.0
Irritable Bowel Disease (IBD) 0.1 0.2 0.6 -0.3 0.7 -0.0 0.1 0.2 -0.5 -0.8 0.4 -0.3 -0.0 0.2
Ulcerative Colitis (UC) 0.5 0.9 2.6 -1.6 -1.0 -0.8 1.1 -0.2 -0.7 -0.8 1.5 0.6 0.9 -0.1
Major Depression (MDD) 0.7 0.8 4.0 -0.4 -0.5 0.7 -2.0 1.0 -0.3 -0.7 -0.7 -0.8 -0.7 1.0
Reaction Time 1.4 2.7 5.7 -1.4 -1.9 -1.6 -0.2 -2.4 0.4 0.5 1.8 2.0 2.1 -1.9
Verbal and Numeric Reasoning (VNR) 0.3 0.8 3.8 0.8 0.7 0.5 -1.9 0.8 -0.7 -0.6 -0.5 -0.8 -0.9 0.6
Breast Cancer 0.1 0.2 1.0 0.4 1.0 -0.4 0.4 -0.5 -0.1 0.4 0.4 0.2 0.1 -0.7
Ovarian Cancer 2.6 3.5 11.0 1.7 2.0 1.3 -1.0 2.0 1.6 1.3 -3.3 -2.2 -2.0 0.8
Prostate Cancer 1.3 1.9 3.9 -0.6 -1.4 -1.6 2.0 -1.2 1.1 1.5 1.3 1.0 1.4 -1.7
Age at First Birth 0.1 0.2 0.9 -0.0 -0.1 0.2 0.0 0.1 -1.0 -0.7 0.3 0.2 0.2 0.4
Bipolar Disorder (2011) 0.8 0.8 2.3 -1.5 -0.6 -0.7 0.0 -0.5 -0.7 -0.3 1.4 1.2 1.0 -0.1
Body Mass Index (BMI) (2010) 0.3 0.4 0.9 0.4 0.8 -0.2 -0.5 -0.7 1.0 1.0 -0.3 0.2 0.6 -0.7
Coronary Artery Disease (CAD) 0.4 0.4 3.3 0.6 -0.3 0.2 1.8 -0.2 0.7 -0.1 -0.5 -0.2 -0.1 -0.3
Crohns Disease (2012) 0.2 0.3 1.5 1.0 1.2 0.0 -0.7 -0.2 0.5 0.3 -0.2 -0.4 -0.1 -0.3
Mean Putamen Volume 0.3 0.4 1.3 0.5 -0.2 -0.3 0.2 -1.1 0.5 0.3 0.4 0.6 0.6 -1.0
Fasting Glucose 0.2 0.2 0.5 -0.5 0.6 0.1 0.4 0.3 -0.7 -0.6 0.4 -0.3 -0.2 0.3
HbA1C 2.7 3.0 7.6 0.2 1.1 1.9 -0.6 2.0 -2.4 -2.8 -0.6 -1.1 -1.5 2.4
HDL Cholesterol 0.5 0.9 3.1 -0.3 -0.1 -1.1 1.8 -1.0 0.9 0.9 0.4 1.2 0.4 -1.0
LDL Cholesterol 0.2 0.2 1.3 0.4 -0.5 0.3 -1.1 0.5 0.0 -0.0 -0.2 -0.4 -0.6 0.4
Lupus 0.4 0.7 2.1 -0.1 0.5 0.5 1.1 0.5 -1.4 -1.3 0.2 -0.6 -0.2 1.1
Neuroticism (2016) 5.0 7.2 17.7 0.4 1.0 2.2 -2.7 3.5 -4.2 -3.2 -0.8 -2.1 -2.5 3.7
Primary Biliary Cirrhosis 0.1 0.2 0.9 -0.3 -0.4 0.3 0.4 0.3 0.7 0.4 -0.9 -0.2 0.0 0.2
Rheumatoid Arthritis 0.1 0.1 0.5 0.4 -0.7 -0.4 -0.5 0.1 0.3 0.6 0.1 -0.0 -0.0 -0.3
Schizophrenia (2014) 1.9 4.1 7.3 -2.7 -2.2 -2.1 2.3 -2.0 0.6 0.8 2.3 1.9 2.5 -1.7
Triglycerides 0.4 0.6 1.8 -1.3 0.5 0.5 -1.2 0.6 -0.9 -1.0 0.4 -0.4 -0.0 1.0
Type 2 Diabetes (T2D) (2012) 2.0 2.3 8.1 2.8 1.1 2.0 -0.3 0.9 0.1 -0.3 -1.8 -1.9 -1.8 1.0
Ulcerative Colitis 0.2 0.3 1.9 -0.6 -1.4 -0.8 -0.4 0.3 0.1 0.1 0.7 0.2 0.0 -0.1
Blood Eosinophil Count 0.2 1.4 2.9 1.2 1.1 1.7 -0.9 0.8 -0.5 -0.7 -1.2 -1.7 -1.3 1.1
Blood Platelet Count 0.1 0.8 3.4 -1.8 -0.4 -1.3 0.2 -0.7 0.6 0.3 0.6 1.4 0.5 -0.3
Blood Red Count 0.7 6.4 11.0 2.5 1.3 3.3 -1.6 3.2 -1.6 -1.9 -2.5 -2.6 -3.2 2.9
Blood White Count 0.1 0.4 1.1 0.3 0.1 -0.3 0.6 -1.0 1.1 0.5 0.1 0.5 0.6 -1.0
Heel T-Score 0.1 1.1 2.6 -0.2 -1.1 -0.8 1.1 -1.4 1.2 1.6 0.5 0.6 1.0 -1.1
BMI 0.5 3.1 10.0 3.2 1.1 0.4 -0.4 -1.0 2.8 2.7 -1.9 -0.7 -0.4 -1.5
Height 0.7 14.2 22.0 -2.9 -3.8 -4.3 2.2 -4.7 3.2 3.3 3.7 3.5 4.4 -4.5
Waist Hip Ratio (WHR) 0.3 1.5 3.4 0.0 -0.2 1.1 -1.1 1.6 -1.6 -1.8 -1.0 -0.6 -1.2 1.6
Systolic Blood Pressure 0.4 1.8 5.3 0.6 -2.3 -1.0 1.8 -1.4 1.4 1.5 0.8 0.6 0.7 -1.6
Smoking Status 1.0 2.3 5.4 -2.0 -1.6 -1.6 1.3 -1.3 -0.6 -0.5 2.3 1.6 1.9 -1.0
Allergy or Eczema 0.2 0.5 1.5 1.2 0.7 0.2 1.0 -0.1 0.5 0.7 -0.7 -0.9 -0.2 -0.4
Cardiovascular Disease 0.2 0.7 3.0 0.6 -0.4 0.9 -0.6 0.5 -1.7 -1.5 0.6 -0.3 -0.3 0.7
Hypothyroidism (self reported) 0.9 2.0 5.8 -0.5 -1.4 -1.1 1.2 -1.2 2.3 2.4 -0.2 0.9 1.1 -1.6
Respiratory disease 0.3 0.7 2.6 1.4 1.6 0.2 -0.4 0.3 0.3 0.5 -1.2 -0.9 -0.9 0.1
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.2 1.0 0.9 1.1 -0.6 0.3 -0.2 -0.2 -0.8 -1.1 -0.5 0.4
Lung FEV1/FVC ratio 0.9 4.8 12.0 -0.9 -2.5 -2.2 3.5 -2.4 1.6 1.7 1.6 1.9 2.4 -2.4
Lung FVC 0.7 3.6 8.9 -2.6 -1.2 -1.5 1.1 -1.7 -1.6 -1.5 3.0 2.4 2.3 -0.8
Neuroticism 8.0 19.2 33.5 3.3 3.7 4.9 -3.2 5.8 -4.0 -3.8 -3.4 -4.9 -5.0 5.3
Chronotype (morning person) 0.5 1.2 3.9 2.0 1.7 0.7 -1.4 -0.1 1.0 0.8 -0.9 -1.1 -0.6 -0.0
Hair Pigment 0.0 0.9 7.4 1.2 -0.2 -0.4 -2.7 -0.2 0.4 0.0 -0.3 0.1 -0.4 -0.4
Tanning 0.5 6.1 9.1 -2.9 -3.0 -2.8 1.9 -2.6 1.5 1.9 2.4 2.5 2.8 -2.5
Hand grip strength (left) 0.3 0.9 3.2 1.0 -0.5 -0.4 0.9 -0.5 1.8 1.7 -0.6 0.0 -0.1 -0.9
Number of treatments/medications taken 3.7 6.7 12.9 3.4 2.3 3.5 -0.4 2.6 -1.1 -1.4 -2.8 -3.6 -2.8 2.5
Average weekly spirits intake 2.3 2.8 5.8 -0.8 -1.1 -1.8 0.6 -2.4 1.0 1.2 2.1 2.4 1.6 -2.2
Sensitivity / hurt feelings 1.9 3.2 9.7 1.1 0.8 1.5 -3.1 2.3 -1.6 -1.4 -1.2 -1.9 -1.5 2.1
Frequency of depressed mood in last 2 weeks 2.7 3.7 7.1 1.9 1.5 2.0 -1.9 2.6 -0.5 -0.2 -2.0 -2.7 -2.4 2.0
Hearing difficulty/problems: Yes 0.1 0.2 1.1 0.4 0.0 -0.2 -1.1 0.3 -0.8 -0.5 -0.2 0.2 -0.0 -0.1
Relative age of first facial hair 1.5 3.1 10.5 -1.5 0.9 1.5 -1.2 1.4 -2.9 -3.2 0.2 -0.5 -0.7 2.4
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.0 -0.1 -0.4 -0.7 0.5 -1.2 1.2 1.3 0.1 0.5 1.0 -1.4
Ever used hormone-replacement therapy (HRT) 1.8 2.3 6.8 -0.8 1.0 1.5 -1.3 1.4 -2.5 -2.6 0.5 -0.6 -0.7 2.0
Ever had hysterectomy (womb removed) 0.1 0.1 0.4 -0.2 -0.7 -0.1 -0.5 -0.0 -0.4 -0.5 0.1 0.3 0.2 -0.1
Systolic blood pressure, automated reading 0.1 0.4 2.0 1.4 -0.6 0.3 1.0 0.0 0.1 0.2 -0.0 -0.4 -0.7 -0.1
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.9 0.7 0.9 -0.0 -0.0 -0.7 0.7 0.6 -0.6 0.5 0.1 -0.7
Angina 1.1 1.5 6.7 2.6 0.4 1.2 1.1 0.3 0.9 0.6 -1.9 -1.0 -1.0 0.0
Medication for hormone replacement therapy 0.2 0.2 0.8 -0.1 -0.4 -0.0 0.9 -0.7 0.2 0.2 0.6 -0.0 0.5 -0.3
Vitamin and mineral supplements 3.5 4.8 8.2 0.9 2.0 2.5 -1.5 2.5 -2.6 -2.7 -1.1 -1.7 -2.5 2.9
Supplements: Zinc 0.3 0.3 1.0 -1.0 -1.0 -0.1 -0.7 -0.3 -0.0 0.2 0.5 0.1 0.5 -0.2
Medication: Co-codamol 0.8 0.9 2.1 0.7 1.5 1.1 -0.9 1.0 -0.9 -1.0 -0.8 -0.8 -0.8 1.0
Medication: Metformin 0.5 0.7 2.0 1.4 1.1 0.9 -1.3 0.2 -0.3 -0.4 -0.7 -1.0 -0.7 0.5
Diabetes (father) 0.5 0.6 1.7 -0.6 -1.3 -0.6 0.1 -0.5 0.9 1.1 0.5 0.2 0.8 -0.8
Diabetes (mother) 0.4 0.6 1.4 0.2 0.9 0.3 -0.1 0.7 -0.9 -1.2 -0.7 -0.4 -0.8 1.1
Severe depression (siblings) 1.1 1.2 4.6 0.9 0.6 -0.7 -0.4 -1.1 2.1 1.8 -0.8 0.1 0.3 -1.2
Pack years adult smoking proportion 2.9 4.4 8.6 2.2 2.0 2.3 -2.2 2.5 -0.4 -0.4 -2.9 -2.3 -2.5 1.9
Impedance of leg (right) 0.8 3.8 9.6 -1.8 -0.2 1.1 -1.2 2.8 -3.1 -3.0 0.0 -0.4 -1.2 2.8
Leg fat-free mass (left) 0.9 4.9 16.6 2.3 0.1 -1.0 0.6 -2.6 4.1 3.8 -0.7 0.1 0.8 -2.9
Trunk fat percentage 0.3 1.4 4.2 2.1 0.4 1.0 -0.3 0.1 1.6 1.4 -1.7 -1.2 -0.8 -0.1
Hand grip strength (right) 0.2 0.5 1.3 1.0 0.2 0.4 0.5 0.7 0.6 0.4 -1.2 -0.9 -1.0 0.5
Townsend deprivation index at recruitment 2.0 2.8 9.0 1.8 -0.3 -0.4 -3.0 -0.3 2.7 2.5 -1.8 -0.1 -0.5 -1.1
Current tobacco smoking 0.7 1.1 2.2 -0.8 -0.9 -1.0 1.1 -1.5 0.9 0.7 0.7 0.8 1.5 -1.3
Average weekly fortified wine intake 1.4 1.6 3.1 -1.2 -0.5 -1.3 1.5 -1.6 0.2 0.2 1.8 1.6 1.6 -1.3
Maternal smoking around birth 1.5 2.2 4.1 1.1 1.2 1.1 -2.0 2.0 -0.7 -0.7 -1.6 -1.7 -1.6 1.9
Fed-up feelings 2.4 4.3 7.3 1.8 2.1 2.2 -2.7 2.5 -1.3 -1.1 -2.1 -2.3 -2.1 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.7 4.9 9.0 2.5 1.8 2.8 -1.8 2.5 -0.5 -0.7 -2.5 -3.0 -2.6 2.2
Relative age voice broke 1.7 2.7 8.0 -0.9 1.5 1.2 -0.9 1.5 -2.8 -2.7 0.7 -0.2 -1.1 2.1
Taking other prescription medications 2.8 4.4 8.4 2.2 2.3 2.9 -0.7 2.1 -1.1 -1.4 -2.1 -2.7 -2.3 2.1
Age when periods started (menarche) 0.8 1.8 7.4 -0.5 0.2 0.4 1.4 0.8 -2.7 -2.1 1.8 -0.0 -0.2 1.5
Bilateral oophorectomy (both ovaries removed) 0.3 0.3 0.8 -0.1 0.3 0.7 -0.9 0.8 -0.2 -0.4 -0.1 -0.5 -0.5 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.7 1.7 0.4 0.3 0.9 1.3 0.7 -1.2 -0.8 0.1 -1.0 -0.6 0.9
Tinnitus: Yes, but not now, but have in the past 0.8 0.9 2.9 0.4 0.1 0.4 -0.1 0.7 1.6 1.7 -1.5 -0.9 -0.7 -0.1
Qualifications: CSEs or equivalent 0.1 0.2 0.6 0.3 0.2 0.0 -0.7 0.8 0.0 0.0 -0.3 -0.3 -0.7 0.3
Serious illness, injury or assault to yourself 0.2 0.3 0.9 0.5 0.6 -0.1 0.7 -0.5 0.6 0.9 -0.2 -0.1 0.3 -0.7
High blood pressure 0.6 1.7 3.3 1.7 0.2 1.8 -0.4 1.3 -1.3 -1.4 -0.3 -1.6 -1.4 1.4
Hayfever, allergic rhinitis or eczema 0.5 1.0 3.2 1.8 1.2 0.7 -0.1 0.4 0.9 1.0 -1.3 -1.2 -0.8 -0.2
Multivitamins +/- minerals 3.1 3.9 6.2 -0.7 -2.4 -2.4 1.9 -1.9 2.5 2.5 0.5 1.4 1.9 -2.4
Stomach or abdominal pain in last month 3.1 3.9 5.8 2.1 2.0 2.2 -1.2 2.4 -1.1 -1.1 -2.4 -2.2 -2.1 2.1
Supplements: Glucosamine 1.9 2.5 7.7 -1.0 -0.9 -2.0 2.8 -1.3 0.9 1.4 1.1 1.4 1.6 -1.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.1 0.9 0.1 -0.0 0.8 -0.3 0.8 1.0 -0.7 0.0 -0.2 -0.6
Medication: Atenolol 0.7 0.9 6.8 0.2 0.8 0.6 2.6 0.2 -0.7 -0.6 0.2 -0.9 0.0 0.6
Medication: Levothyroxine sodium 0.4 0.7 2.5 -0.3 -1.6 -0.6 0.9 -0.2 1.3 1.2 -0.4 0.5 0.2 -0.5
Sitting height 0.3 2.2 7.3 0.3 -0.9 -0.8 -0.2 -1.8 2.7 2.5 0.1 0.6 1.1 -2.1
Chronic bronchitis/emphysema (father) 2.2 2.6 6.9 1.8 1.6 1.4 0.1 1.6 0.5 0.2 -2.6 -2.1 -2.3 1.1
High blood pressure (mother) 0.6 0.9 2.0 1.3 0.7 0.8 0.6 -0.1 1.4 1.2 -1.3 -1.1 -0.4 -0.3
Body mass index (BMI) 1.1 4.7 16.4 4.1 2.2 1.9 -0.1 1.1 1.5 1.3 -3.0 -2.5 -2.4 0.6
Impedance of leg (left) 0.6 2.9 7.1 -2.1 -0.5 0.8 -1.1 2.3 -2.7 -2.6 0.1 -0.1 -0.8 2.4
Leg predicted mass (left) 0.9 4.9 16.9 2.4 0.1 -0.9 0.4 -2.5 4.1 3.9 -0.9 -0.0 0.7 -2.8
Trunk fat mass 0.5 2.1 6.2 2.4 0.3 0.7 -0.2 -0.5 2.5 2.3 -1.8 -1.1 -0.6 -0.8
Waist circumference 1.0 3.8 11.7 3.4 1.3 1.4 -0.1 0.7 2.3 1.9 -3.1 -2.0 -1.9 0.0
Number of incorrect matches in round 2.8 4.7 12.0 -2.4 -1.8 -2.0 1.8 -2.4 -0.5 -0.5 3.5 2.7 2.7 -1.6
Past tobacco smoking 1.1 2.0 5.3 2.0 2.3 1.3 -1.0 0.8 0.9 0.7 -2.0 -1.5 -1.4 0.4
Alcohol usually taken with meals 0.5 0.8 1.5 -1.2 -1.0 -0.9 0.1 -1.1 0.8 0.4 1.0 0.6 1.1 -1.0
Nervous feelings 7.2 13.4 23.4 3.7 3.4 3.8 -2.2 4.8 -1.9 -2.1 -3.4 -4.4 -4.8 4.1
Frequency of tenseness / restlessness in last 2 weeks 4.4 6.9 12.2 2.6 2.6 2.8 -1.9 3.4 -1.7 -1.6 -1.9 -3.5 -3.2 3.0
Hearing difficulty/problems with background noise 1.2 1.9 3.4 -1.0 -1.6 -1.8 -0.4 -1.4 0.3 1.0 1.3 1.7 1.7 -1.8
Hair/balding pattern: Pattern 2 1.6 2.0 5.5 0.5 2.4 1.9 -1.6 1.7 -0.7 -0.8 -1.1 -1.4 -1.2 1.4
Had menopause 0.6 0.8 3.0 -0.8 0.2 -0.2 0.0 -0.1 -1.7 -1.6 1.0 0.8 0.4 0.6
Had other major operations 0.2 0.3 0.8 -0.0 0.5 -0.3 -0.9 -0.9 0.2 0.1 0.2 0.9 0.2 -0.6
Forced vital capacity (FVC) 0.5 1.9 3.7 -1.9 -1.9 -1.3 0.1 -1.3 0.3 0.5 1.4 1.6 1.9 -1.1
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.2 0.8 0.1 -0.9 0.1 0.9 0.1 0.0 0.5 -0.1 -0.4 -0.2 0.1
Ever unenthusiastic/disinterested for a whole week 2.7 3.3 11.3 1.8 0.9 1.2 -2.1 2.0 1.4 1.2 -3.4 -1.7 -2.1 1.0
Qualifications: None of the above 0.4 0.8 3.2 0.2 0.6 0.5 0.5 0.0 1.8 1.0 -1.8 -0.6 -0.2 -0.1
Financial difficulties in last 2 years 0.9 1.3 3.8 1.9 0.2 0.7 -1.4 0.7 0.9 1.1 -1.9 -0.9 -1.0 -0.0
Mouth/teeth dental problems 1.6 2.5 3.9 -1.3 -1.3 -1.8 2.0 -1.9 1.3 1.2 1.4 1.6 1.7 -1.6
Heart attack 2.0 2.6 5.7 2.1 0.7 2.4 0.2 1.4 0.5 0.1 -2.3 -2.4 -1.7 1.3
Allergy 0.8 1.9 5.2 -2.3 -1.2 -0.8 0.4 -0.3 -1.7 -1.8 1.9 1.5 0.9 0.5
Pain all over the body in last month 1.6 1.8 6.6 1.0 0.6 -0.3 -1.4 -0.6 2.5 2.6 -1.1 -0.5 0.1 -1.2
Diabetes (self-reported) 0.2 0.3 0.8 0.8 0.2 0.9 -0.5 0.0 -0.3 -0.5 -0.7 -0.4 -0.2 0.3
Hayfever/allergic rhinitis (self-reported) 1.9 2.5 5.2 2.3 1.6 1.5 -0.2 1.1 1.1 0.8 -2.3 -2.1 -2.0 0.6
Medication: Ramipril 0.2 0.2 0.6 -0.8 -0.6 -0.1 0.4 -0.5 -0.3 -0.6 0.5 0.3 0.5 -0.2
Medication: Simvastatin 0.6 0.9 3.3 0.4 -0.6 -0.7 1.8 -1.0 1.2 1.0 -0.1 -0.1 0.7 -1.2
Fluid intelligence score 0.9 1.8 7.2 1.0 1.1 1.1 -2.7 1.2 -0.3 -0.5 -1.5 -1.3 -1.6 1.1
Illnesses of siblings 0.4 0.5 2.2 0.5 -0.2 -0.5 -0.4 -0.5 1.3 1.5 -0.0 0.3 0.2 -0.8
Neuroticism score 5.8 12.1 21.0 2.6 2.2 3.7 -3.7 4.6 -2.9 -2.8 -2.8 -3.9 -4.1 4.2
Weight 0.7 3.5 10.6 3.1 0.8 0.4 0.3 -0.8 3.3 3.0 -2.0 -1.1 -0.7 -1.3
Impedance of arm (right) 0.3 1.5 6.9 -2.6 -1.6 -0.5 0.1 -0.1 -1.2 -1.1 1.4 0.8 1.3 0.3
Arm fat percentage (right) 1.0 3.9 12.8 3.6 1.8 2.0 -0.0 1.0 1.4 1.1 -2.8 -2.5 -2.1 0.7
Trunk fat-free mass 0.7 4.0 12.8 1.6 -0.2 -1.2 0.6 -2.3 3.6 3.5 -0.3 0.5 0.8 -2.7
Hip circumference 0.7 3.1 9.1 3.0 1.4 1.0 -0.5 0.0 2.6 2.3 -2.3 -1.4 -1.2 -0.5
Time employed in main current job 0.9 1.0 2.2 -0.1 -0.6 -0.9 0.8 -1.5 1.2 1.3 0.8 0.7 1.2 -1.2
Alcohol intake versus 10 years previously 0.4 0.6 2.0 1.4 -0.1 0.8 -0.6 0.5 -0.4 -0.4 -0.9 -0.9 -0.8 0.7
Father’s age at death 1.1 1.5 5.3 -2.3 -0.8 -0.8 1.3 -1.2 0.1 -0.2 1.6 1.4 1.4 -0.7
Worrier / anxious feelings 4.0 7.6 12.3 2.4 1.6 3.0 -2.9 3.5 -1.6 -2.0 -2.9 -3.1 -3.3 3.2
Frequency of tiredness / lethargy in last 2 weeks 3.3 5.4 9.7 1.6 2.2 2.4 -2.2 3.1 -1.1 -1.4 -2.6 -2.5 -2.8 2.7
Falls in the last year 0.2 0.3 2.5 0.5 0.5 0.2 -1.6 0.1 0.4 0.3 -0.1 -0.3 -0.5 0.1
Hair/balding pattern: Pattern 3 0.5 0.7 2.1 0.4 -0.6 -1.0 0.7 -1.4 0.5 0.5 0.6 0.7 1.0 -1.1
Number of live births 0.2 0.3 1.8 -0.1 -1.3 0.1 -0.1 0.3 0.8 0.3 -0.7 -0.0 -0.0 -0.0
Forced expiratory volume in 1-second (FEV1) 0.8 2.5 6.2 -1.9 -2.5 -1.6 1.0 -1.4 0.8 1.1 1.3 1.7 2.0 -1.4
Pulse rate 0.5 0.9 1.4 0.5 1.1 1.2 0.5 1.1 -0.9 -1.2 -0.6 -1.0 -1.1 1.1
Happiness 2.0 2.5 5.1 2.0 2.2 1.7 -1.3 1.5 -0.3 -0.4 -1.9 -1.8 -1.6 1.2
Noisy workplace 0.4 0.5 2.6 0.3 -0.3 0.7 1.6 0.8 -0.6 -0.5 -0.3 -0.5 -0.4 0.9
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.4 -0.7 -0.6 -0.0 -1.2 0.1 -1.0 -0.8 0.8 0.3 0.2 0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.5 2.5 -1.2 -1.6 -0.4 -0.9 0.0 0.1 0.1 0.8 0.3 0.5 -0.0
Mouth/teeth dental problems: Dentures 1.2 2.0 6.7 1.4 2.6 1.6 -0.4 1.1 -1.8 -1.4 -0.6 -0.8 -1.1 1.3
Asthma 0.6 1.2 2.5 1.6 1.4 0.7 -0.9 0.6 0.8 0.9 -1.5 -1.4 -1.2 0.4
Medication: Ibuprofen (e.g. Nurofen) 0.8 1.1 5.9 -0.7 -2.4 -0.7 -0.2 -1.1 0.7 0.6 0.3 1.0 1.0 -1.0
Medication: Cholesterol lowering 0.6 1.0 5.6 0.8 -0.3 -0.0 2.4 -0.4 1.4 1.1 -0.6 -0.4 0.2 -0.8
Depression (self-reported) 5.8 6.9 11.4 3.0 2.4 3.2 -1.5 3.2 -0.9 -1.0 -2.7 -3.1 -3.4 2.8
Medication: Lansoprazole 2.7 3.0 6.2 -0.1 1.4 2.3 0.6 2.1 -2.2 -2.5 -1.4 -1.3 -1.1 2.3
Prospective memory result 0.2 0.3 2.0 -1.4 -0.4 0.1 0.5 -0.2 -0.1 -0.1 0.2 -0.0 0.7 0.0
Lung cancer (father) 0.4 0.5 3.1 0.5 0.1 0.1 -1.7 0.6 -0.0 -0.1 -0.3 -0.5 -0.9 0.5
Illnesses of mother 0.3 0.4 1.2 -0.9 -1.1 -0.7 0.2 -0.4 0.3 0.4 0.6 0.8 0.5 -0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.2 3.8 -1.8 -1.9 -1.6 0.2 -1.6 0.2 0.4 1.8 1.9 1.9 -1.3
Pulse wave Arterial Stiffness index 0.4 0.5 1.2 0.5 0.4 0.6 -1.1 0.6 -1.1 -0.8 0.0 -0.6 -0.5 0.7
Impedance of arm (left) 0.6 2.9 11.3 -3.4 -2.2 -1.1 -0.2 -0.6 -1.4 -1.2 2.2 1.6 1.8 -0.1
Arm fat mass (right) 0.8 3.4 11.8 3.4 1.7 1.3 -0.1 0.2 2.2 2.0 -2.5 -2.0 -1.5 -0.2
Trunk predicted mass 0.7 3.9 12.4 1.7 -0.2 -1.2 0.5 -2.3 3.5 3.5 -0.2 0.5 0.8 -2.7
Standing height 1.1 10.9 19.0 -2.0 -2.9 -3.5 0.8 -4.3 3.9 3.9 2.3 3.0 3.7 -4.4
Length of working week for main job 1.3 1.5 3.1 1.3 1.1 1.8 -0.6 1.2 -0.5 -0.6 -1.4 -1.6 -1.2 1.4
Exposure to tobacco smoke at home 0.2 0.3 0.7 -0.5 0.5 -0.1 -0.8 -0.4 -0.5 -0.3 0.4 0.8 0.5 -0.1
Breastfed as a baby 0.4 0.5 1.2 -0.1 0.7 0.5 0.7 0.9 -0.6 -0.7 -0.4 -0.6 -0.8 1.1
Tense / ‘highly strung’ 2.4 3.9 7.0 1.2 1.9 1.7 -2.0 2.6 -2.2 -1.9 -0.4 -1.9 -2.4 2.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 2.4 1.0 0.1 1.3 -1.5 1.4 -1.4 -1.1 -0.9 -1.2 -1.2 1.5
Hair/balding pattern: Pattern 4 0.2 0.4 1.6 -0.1 0.3 -0.6 1.3 -0.5 0.7 0.8 0.4 0.3 0.2 -0.7
Birth weight of first child 0.2 0.4 1.0 0.4 -0.1 -0.4 0.9 -0.9 0.1 0.4 0.7 1.0 0.3 -0.7
Peak expiratory flow (PEF) 0.2 0.4 1.4 0.0 -1.2 -0.1 0.3 0.9 0.6 0.7 -1.1 -0.3 -0.4 0.4
Pulse wave reflection index 0.5 0.6 1.7 -0.8 -1.3 -0.5 -0.3 -0.2 -1.3 -0.8 1.0 0.4 0.6 0.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.4 0.6 0.3 1.0 0.2 1.2 -0.1 0.0 -1.6 -0.9 -1.1 0.7
Loud music exposure frequency 0.3 0.3 1.2 -0.0 -0.5 -0.4 -0.5 -0.7 1.1 0.7 -0.0 0.2 0.4 -0.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 4.8 0.4 0.2 0.3 -2.2 1.0 -0.5 -0.1 -0.2 -0.3 -0.9 0.5
Mouth/teeth dental problems: Bleeding gums 0.6 0.8 2.0 -0.7 -1.4 -0.9 0.5 -0.8 0.8 1.0 0.8 0.4 0.8 -1.0
Blood clot in the leg (DVT) 0.5 0.6 1.5 -0.1 -1.2 -0.7 0.9 -0.7 1.0 1.2 0.2 0.4 0.6 -0.9
Medication: Paracetamol 1.5 2.5 4.8 0.6 2.2 1.7 -1.4 1.6 -1.9 -2.0 -0.5 -1.4 -1.2 2.0
Headache pain in last month 0.9 1.6 2.9 1.1 1.4 1.3 -0.8 1.7 -1.0 -0.7 -1.1 -1.4 -1.7 1.5
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 2.1 -1.3 -0.3 -0.6 -1.4 0.2 0.1 0.0 0.0 0.8 -0.1 0.3
Glaucoma (self-reported) 0.4 0.5 1.8 -0.2 1.0 -0.2 -1.3 -0.1 1.1 1.1 -0.2 -0.2 0.1 -0.5
Gout (self-reported) 1.1 1.5 4.3 -0.8 -0.3 -0.9 2.0 -0.9 2.1 1.9 -0.1 0.3 0.9 -1.2
Hypothyroidism/myxoedema (self-reported) 0.7 1.3 2.5 -1.1 -1.6 -1.2 0.6 -0.8 1.4 1.6 0.4 1.1 1.1 -1.1
Medication: Amlodipine 0.8 1.1 2.1 1.3 -0.5 1.2 -0.5 1.3 0.0 0.0 -1.4 -1.4 -1.1 1.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.6 1.3 0.9 0.2 1.3 0.0 -0.0 0.2 -0.4 -0.7 -0.6 0.1
Birth weight 0.7 1.5 3.4 1.2 1.2 1.1 1.1 0.8 1.4 0.8 -1.8 -1.6 -1.1 0.6
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.6 0.3 -0.4 -0.4 -0.0 0.1 0.8 0.7 -0.2 -0.0 -0.1 -0.0
High blood pressure (siblings) 0.4 0.6 1.3 -0.5 -1.2 -0.9 0.8 -0.9 0.1 0.3 0.5 0.9 0.9 -1.0
Forced vital capacity (FVC), Best measure 0.9 3.4 6.1 -2.3 -1.9 -1.9 -0.1 -2.1 0.3 0.5 2.2 2.4 2.5 -1.7
Body fat percentage 0.8 3.0 8.3 2.9 1.3 1.8 -0.4 1.1 1.2 1.0 -2.7 -2.1 -1.9 0.8
Leg fat percentage (right) 2.3 8.2 16.1 4.0 2.7 3.3 -0.5 2.9 0.0 -0.4 -3.8 -3.5 -3.7 2.4
Arm fat-free mass (right) 0.6 3.3 11.0 2.0 0.2 -0.9 -0.1 -1.9 3.3 3.2 -0.6 0.4 0.5 -2.4
Exposure to tobacco smoke outside home 0.2 0.3 1.6 1.3 0.0 0.5 -0.9 -0.1 -0.6 -0.3 -0.1 -0.1 -0.2 0.2
Comparative body size at age 10 0.8 2.2 7.8 0.3 -1.2 -0.9 1.0 -1.3 2.8 2.6 -0.8 0.7 0.2 -1.8
Number of full brothers 1.0 1.3 4.6 1.6 1.0 1.0 -0.5 1.0 0.5 0.3 -2.1 -1.0 -1.5 0.7
Worry too long after embarrassment 3.3 5.5 11.4 1.4 1.3 2.5 -3.4 2.9 -1.7 -2.1 -2.0 -2.3 -2.7 2.8
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 3.1 1.5 0.4 1.0 -1.8 1.4 -0.2 -0.1 -1.0 -1.3 -1.6 1.1
Wheeze or whistling in the chest in last year 1.8 3.3 5.7 2.4 2.3 1.8 -1.4 1.6 0.4 -0.0 -2.4 -2.3 -2.0 1.4
Number of children fathered 0.1 0.1 0.6 -0.7 0.1 0.2 -0.5 0.2 0.0 0.4 0.2 -0.3 0.3 0.2
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.6 0.6 -0.1 -0.6 -0.4 -0.8 0.8 0.3 0.5 -0.1 0.3 -0.7
Age at first live birth 1.5 2.6 8.1 -2.8 -0.4 -0.9 1.0 -0.9 -1.8 -1.6 2.6 1.5 1.7 -0.2
Pulse wave peak to peak time 0.6 0.6 1.9 -0.5 -0.5 -0.7 1.0 -0.7 1.4 1.1 -0.0 0.7 0.6 -0.9
Health satisfaction 3.3 4.3 7.2 2.7 2.7 2.6 -1.4 1.9 -0.7 -0.6 -2.6 -2.4 -2.1 1.7
Shortness of breath walking on level ground 0.9 1.1 2.6 0.8 0.4 1.0 -1.6 1.3 -0.7 -0.5 -1.0 -1.0 -1.3 1.1
Qualifications: College or University degree 0.8 2.6 10.4 -1.8 -0.2 -0.0 -1.1 -0.1 -3.2 -2.4 2.6 0.7 0.8 0.5
Eye problems/disorders: None of the above 0.1 0.1 0.4 0.5 0.2 0.0 0.7 0.2 0.4 0.3 -0.5 -0.4 -0.2 -0.1
Mouth/teeth dental problems: Loose teeth 0.9 1.1 3.1 0.5 0.8 1.1 -0.5 1.8 -0.1 -0.5 -1.2 -1.3 -1.3 1.1
Emphysema/chronic bronchitis 0.2 0.2 0.6 0.4 0.3 -0.0 -0.4 -0.5 0.4 0.6 -0.4 0.3 0.2 -0.8
Medication for pain relief, constipation, heartburn 2.3 3.9 6.5 -2.0 -2.2 -2.6 0.9 -2.2 1.0 1.2 2.0 2.6 2.3 -2.0
Neck or shoulder pain in last month 0.6 0.8 1.6 1.3 0.4 0.7 0.5 1.2 -0.1 -0.2 -1.2 -1.1 -1.2 0.7
Medication: Blood pressure 0.2 0.4 2.1 1.5 0.5 0.8 0.7 -0.0 -0.3 -0.2 0.1 -0.8 -0.1 -0.1
Angina (self-reported) 0.9 1.2 4.7 2.2 -0.0 1.0 1.4 0.1 1.0 0.7 -1.7 -0.8 -0.7 -0.1
Migraine (self-reported) 2.7 3.4 6.0 1.1 1.3 2.0 -1.5 2.2 -1.7 -1.9 -1.8 -1.7 -2.0 2.4
Medication: Ibuprofen 0.6 0.7 3.2 -0.6 -1.8 -0.4 -0.6 -1.1 0.5 0.4 0.3 0.9 0.9 -0.9
Medication: Allopurinol 0.6 0.7 4.2 -1.2 -0.7 -0.6 2.0 -0.3 0.7 0.6 0.3 0.2 0.7 -0.4
Medication: Omeprazole 0.2 0.2 0.5 0.6 0.3 0.4 0.3 0.3 -0.1 -0.3 -0.4 -0.6 -0.7 0.4
Medication: Seretide 50 evohaler 1.0 1.2 2.5 0.4 -0.5 -0.7 -1.2 -1.6 1.5 1.6 0.2 1.1 0.7 -1.4
Mean time to correctly identify matches 1.6 3.0 5.8 -1.7 -2.0 -1.6 0.6 -2.4 0.1 0.1 2.0 2.2 2.2 -1.8
Heart disease (mother) 0.5 0.7 3.1 0.4 0.9 0.4 -0.5 -0.1 -1.8 -1.5 0.6 0.2 0.2 0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.0 1.1 3.7 0.7 -0.2 -1.1 1.9 -0.5 1.9 1.4 -0.7 -0.3 0.3 -0.9
Whole body fat mass 0.7 2.9 9.4 3.1 1.0 1.2 -0.1 0.2 2.3 2.0 -2.5 -1.7 -1.3 -0.2
Leg fat mass (right) 1.2 4.7 15.8 4.0 1.9 2.0 -0.2 1.1 1.7 1.3 -3.2 -2.5 -2.3 0.6
Arm predicted mass (right) 0.6 3.1 10.9 1.8 0.2 -0.9 -0.2 -1.8 3.3 3.2 -0.6 0.3 0.4 -2.3
Pulse rate, automated reading 0.3 0.9 1.8 -0.3 -1.3 -1.0 1.3 -1.3 0.2 -0.1 1.3 1.0 0.7 -1.0
Alcohol intake frequency. 2.5 5.9 16.1 1.5 1.9 2.4 -4.0 2.9 -0.3 -0.6 -3.2 -2.1 -2.7 2.5
Comparative height size at age 10 2.7 14.9 24.6 -2.1 -4.3 -3.8 2.4 -4.9 4.6 4.3 2.4 2.9 4.3 -5.0
Number of full sisters 0.8 1.0 2.7 1.6 1.0 0.5 -0.7 0.7 0.9 0.5 -1.6 -1.3 -1.1 0.4
Suffer from ‘nerves’ 3.3 5.2 9.8 2.0 2.1 2.3 -1.7 3.1 -1.4 -1.6 -1.9 -2.8 -2.8 2.8
Overall health rating 6.6 14.3 27.7 5.3 3.9 4.3 -1.5 3.8 -0.5 -1.1 -5.0 -4.7 -4.5 3.1
Chest pain or discomfort 3.0 4.3 8.1 1.9 1.1 2.2 -2.6 2.6 -0.2 -0.3 -2.9 -2.3 -2.6 2.0
Had major operations 0.8 0.9 2.0 1.2 1.4 1.0 -0.2 0.8 0.7 0.6 -1.2 -1.3 -1.1 0.5
Age at last live birth 0.3 0.4 1.3 -1.2 -0.4 0.3 0.4 0.2 -1.0 -0.9 0.9 -0.0 0.4 0.5
Family relationship satisfaction 0.9 1.1 2.0 1.3 0.9 1.2 -1.4 0.9 0.2 -0.0 -1.4 -1.4 -1.0 1.1
Leg pain on walking 0.6 0.7 2.7 0.0 -1.6 -0.6 0.5 -0.4 1.0 1.3 -0.5 0.6 0.5 -0.8
Qualifications: NVQ or HND or HNC or equivalent 2.1 2.5 5.7 2.4 1.7 1.6 0.7 1.7 0.1 -0.0 -1.9 -1.7 -2.1 1.3
Commuting to job workplace: Car/motor vehicle 3.1 3.5 6.9 1.6 1.5 2.0 -0.2 2.6 -0.3 -0.7 -2.3 -2.5 -2.5 2.3
Illness, injury, bereavement, stress in last 2 years 1.0 1.2 4.0 -1.7 0.7 -0.1 0.5 -0.1 -1.7 -2.0 1.4 0.6 0.6 0.7
Medication: Aspirin 1.7 2.3 4.6 2.1 1.5 2.0 0.2 1.5 -0.1 -0.6 -2.0 -1.7 -1.9 1.2
Supplements: Vitamin C 0.9 1.1 2.0 0.0 -0.7 -1.3 0.6 -1.3 1.1 1.0 1.1 0.8 1.2 -1.4
Knee pain experienced in last month 0.2 0.3 0.7 0.7 0.5 0.2 0.2 0.7 0.0 -0.2 -0.8 -0.8 -0.7 0.5
Hypertension (Self-reported) 0.5 1.4 3.3 1.8 0.0 1.6 -0.0 1.0 -1.4 -1.4 -0.2 -1.3 -1.2 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.5 2.9 4.9 1.1 1.9 1.8 0.0 2.2 -1.9 -1.7 -1.1 -1.9 -1.7 2.2
Illnesses of father: Heart disease 1.4 2.0 8.5 -0.3 0.0 1.0 0.2 0.8 -2.9 -2.8 0.9 -0.0 -0.4 1.7
Illnesses of siblings: Diabetes 3.6 4.4 7.6 1.8 2.8 2.6 -0.9 2.3 -0.8 -1.3 -2.3 -2.7 -2.3 2.2
Smoking status: Previous 1.0 1.5 4.4 -1.9 -2.1 -1.1 0.7 -0.4 -0.7 -0.6 1.5 1.2 1.3 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.7 -0.2 -0.8 -0.7 -0.2 -1.6 1.2 1.3 0.4 1.0 1.2 -1.4
Whole body fat-free mass 0.8 4.7 16.4 2.1 -0.0 -1.1 0.5 -2.4 4.0 3.9 -0.6 0.3 0.7 -2.9
Leg fat-free mass (right) 1.0 5.1 17.1 2.1 0.0 -1.0 0.5 -2.8 4.1 3.9 -0.7 0.2 1.0 -3.0
Arm fat percentage (left) 0.8 3.0 10.2 3.2 1.4 1.7 -0.2 0.7 1.5 1.2 -2.6 -2.1 -1.7 0.4
Average weekly red wine intake 2.8 4.1 9.0 -2.4 -1.7 -2.3 1.1 -2.3 0.4 0.7 3.0 1.9 2.9 -1.8
Handedness (chirality/laterality): Left-handed 0.7 0.9 2.1 -0.4 0.7 0.0 1.0 -1.3 -1.2 -1.2 1.4 0.7 1.0 -0.4
Mood swings 6.2 11.2 19.4 3.3 3.1 4.0 -1.5 4.3 -1.9 -1.8 -3.3 -4.4 -3.8 3.7
Loneliness, isolation 2.5 3.5 10.5 1.9 0.5 1.4 -3.2 2.3 -0.5 -0.2 -2.2 -1.8 -2.3 1.7
Long-standing illness, disability or infirmity 0.8 1.3 2.6 1.2 1.6 1.3 -0.9 1.0 -0.5 -0.7 -1.2 -1.2 -1.3 0.9
Ever had bowel cancer screening 1.5 1.8 3.4 1.4 1.5 1.7 -0.4 1.7 -0.5 -0.5 -1.4 -1.8 -1.4 1.3
Diabetes diagnosed by doctor 1.0 1.7 3.6 1.7 1.2 1.9 -0.9 1.1 -0.4 -0.7 -1.6 -1.5 -1.2 1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.4 1.3 0.3 -1.1 -0.4 0.2 -0.6 0.9 0.6 -0.2 0.3 0.4 -0.5
Friendships satisfaction 0.2 0.3 1.0 -0.0 0.9 0.7 -0.4 0.4 0.1 0.0 -0.5 -1.0 -0.2 0.5
Qualifications: nursing, teaching 0.1 0.2 0.6 -0.2 0.1 -0.1 -0.3 -0.3 -0.8 -0.5 0.7 0.4 0.3 -0.2
Commuting to job workplace: Walk 2.8 3.0 5.5 -2.0 -1.7 -2.0 1.1 -1.9 -0.5 0.1 2.4 2.3 2.1 -1.5
Eye problems/disorders: Cataract 0.3 0.4 1.0 -0.3 -0.5 -0.7 0.0 -1.0 0.4 0.3 1.0 0.5 0.7 -0.5
Mouth/teeth dental problems: Mouth ulcers 1.6 2.5 4.0 0.2 0.7 1.9 -1.9 1.9 -1.6 -1.9 -1.3 -1.4 -1.4 2.0
Medication for cholesterol 0.4 0.7 1.2 -1.1 0.2 -0.9 -0.4 -0.7 1.0 0.9 0.2 1.1 0.9 -0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.2 2.6 3.9 1.6 1.9 1.8 -0.7 2.0 -0.7 -1.0 -1.9 -1.7 -2.0 1.5
Back pain experienced in last month 1.7 2.5 4.9 1.6 2.2 1.6 -0.8 2.0 0.0 -0.2 -2.1 -1.8 -1.8 1.5
Mineral and other dietary supplements 5.8 7.8 12.6 1.8 3.5 3.6 -2.8 3.0 -1.6 -2.2 -2.4 -2.9 -2.9 3.3
Breast cancer (self-reported) 0.5 0.6 2.0 -0.9 -1.4 -0.5 0.2 -0.1 -1.1 -0.8 1.3 0.4 -0.0 0.2
Asthma (self-reported) 0.7 1.5 3.0 1.7 1.7 0.9 -0.9 0.9 0.5 0.6 -1.6 -1.5 -1.4 0.6
Osteoporosis (self-reported) 1.7 2.1 4.6 1.1 1.4 1.6 -0.3 2.1 -0.5 -0.8 -1.5 -1.5 -2.1 1.8
Osteoarthritis (self-reported) 0.5 0.7 2.4 0.4 -0.5 -0.4 0.5 -0.6 1.4 1.5 -0.9 -0.1 0.7 -1.1
Medication: Aspirin 1.9 2.4 5.7 2.4 1.4 2.1 0.4 1.4 -0.1 -0.4 -1.9 -1.9 -1.9 1.2
Medication: Gliclazide 0.3 0.3 1.1 -0.2 -0.3 0.3 -1.1 -0.5 -0.8 -0.8 0.5 -0.0 0.3 0.2
Illnesses of father: None of the above (group 1) 1.1 1.4 2.9 -0.8 -0.6 -1.7 -1.1 -1.0 0.9 1.2 1.0 1.6 1.1 -1.4
Smoking status: Current 0.9 1.4 2.7 -0.8 -1.0 -1.2 1.3 -1.6 0.8 0.8 1.1 1.0 1.5 -1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.2 5.6 -2.0 -0.7 -1.1 1.0 -1.3 -1.3 -1.3 2.4 1.9 1.7 -0.5
Whole body water mass 0.8 4.7 15.7 2.0 -0.1 -1.2 0.4 -2.5 4.0 3.8 -0.5 0.4 0.8 -2.9
Leg predicted mass (right) 0.9 4.9 16.5 2.1 0.1 -1.0 0.4 -2.7 4.1 3.9 -0.7 0.2 0.9 -2.9
Arm fat mass (left) 0.7 2.9 10.9 3.3 1.5 1.1 -0.1 0.0 2.1 1.9 -2.3 -1.7 -1.3 -0.3
Number of self-reported non-cancer illnesses 5.0 8.7 15.0 3.6 3.0 3.9 -1.8 3.1 -1.8 -1.7 -2.7 -3.6 -3.4 2.9
Average weekly champagne plus white wine intake 0.6 0.8 2.4 -0.6 0.8 -0.1 -1.6 -0.7 -1.2 -1.0 1.5 0.1 0.7 -0.0
Miserableness 4.5 7.8 13.8 2.0 2.2 3.1 -1.8 3.7 -2.3 -2.3 -2.8 -3.3 -3.2 3.3
Guilty feelings 3.5 5.3 14.1 1.1 1.3 2.0 -3.8 2.8 -2.4 -2.4 -1.2 -2.2 -2.2 2.6
Wears glasses or contact lenses 0.4 0.5 1.5 0.6 0.7 0.9 -0.5 -0.2 -1.2 -1.2 0.1 -0.1 0.2 0.3
Ever taken oral contraceptive pill 0.4 0.4 1.4 -0.6 0.3 0.3 -0.5 0.4 -1.1 -1.2 0.5 -0.2 0.2 0.9
Hearing aid user 0.4 0.5 0.9 -0.5 0.8 -0.3 -0.7 -0.4 -1.0 -0.9 0.9 0.8 0.6 -0.2
Mother’s age at death 0.3 0.4 1.2 -0.1 0.5 -0.5 -0.8 -0.3 -0.7 -0.8 1.1 0.7 0.1 -0.2
Financial situation satisfaction 1.3 1.6 3.4 -0.2 -0.9 -1.3 1.3 -1.2 1.8 1.7 -0.2 1.0 1.4 -1.8
Tinnitus: Yes, now most or all of the time 2.2 2.6 4.5 -1.5 -2.1 -2.1 0.5 -1.7 0.3 0.5 2.0 2.1 1.7 -1.7
Commuting to job workplace: Public transport 0.9 1.1 1.9 -0.6 -1.2 -1.1 -0.9 -1.4 0.5 0.4 1.1 1.2 1.3 -1.1
Eye problems/disorders: Glaucoma 0.7 0.8 4.1 0.4 1.4 0.5 -2.0 0.6 0.4 0.3 -0.7 -0.9 -0.6 0.3
Medication: Blood pressure 0.3 0.5 1.1 0.9 -0.8 0.5 0.8 0.5 -0.9 -1.1 -0.1 -0.6 -0.8 0.6
Pain type(s) experienced in last month: Hip pain 1.1 1.4 5.7 1.7 -0.2 0.6 0.1 0.7 1.7 1.4 -2.4 -0.7 -1.0 -0.0
Supplements: Fish oil (including cod liver oil) 3.9 5.1 10.2 -1.6 -3.2 -2.9 1.9 -2.4 1.5 1.8 1.9 2.3 2.3 -2.5
High cholesterol (Self-reported) 0.4 0.7 1.3 1.1 0.6 1.0 1.1 1.0 -0.4 -0.1 -0.7 -1.1 -0.9 0.8
Medication: Bendroflumethiazide 0.3 0.5 2.5 1.6 -0.2 0.9 0.9 0.0 0.5 0.3 -0.6 -0.7 -0.6 -0.0
Medication: Paracetamol 0.7 1.1 2.1 0.6 1.5 1.1 -1.1 1.0 -1.2 -1.3 -0.4 -1.0 -0.7 1.2
Medication: Lisinopril 0.6 0.8 2.1 0.6 0.4 1.2 0.3 0.8 -1.3 -1.5 0.0 -0.9 -0.7 1.0
Medication: Atorvastatin 1.3 1.7 3.2 1.3 0.6 1.8 0.3 1.8 -0.0 0.1 -1.7 -1.6 -1.7 1.2
Illnesses of father: High blood pressure 0.1 0.1 0.7 -0.3 0.3 0.3 0.4 -0.1 -0.2 -0.1 0.8 -0.2 0.4 0.0
Alcohol drinker status: Never 0.2 0.2 0.5 -0.7 0.6 0.5 -0.5 0.4 -0.4 -0.4 0.0 0.0 0.1 0.6
Ever smoked 2.5 4.3 9.3 -3.1 -2.8 -2.1 1.2 -1.8 -0.7 -0.5 2.8 2.5 2.4 -1.2
Basal metabolic rate 0.8 4.2 15.0 2.4 0.3 -0.7 0.4 -2.0 3.9 3.7 -1.0 -0.1 0.3 -2.5
Leg fat percentage (left) 1.8 6.5 14.2 3.8 2.4 2.9 -0.3 2.4 0.5 0.1 -3.6 -3.1 -3.2 1.9
Arm fat-free mass (left) 0.7 3.6 12.2 2.5 0.5 -0.7 -0.1 -1.7 3.5 3.5 -0.9 -0.0 0.1 -2.2
Number of operations (self-reported) 0.7 1.1 3.0 1.1 1.5 1.3 -1.7 0.6 -0.2 -0.6 -0.9 -0.6 -1.0 0.7
Average weekly beer plus cider intake 0.2 0.3 1.6 -0.7 -1.3 0.0 0.4 0.6 -0.3 -0.3 -0.0 0.1 -0.1 0.7
Irritability 0.3 0.6 1.5 0.7 -0.3 0.7 0.1 1.0 -0.9 -0.4 -0.1 -1.2 -0.8 1.0
Risk taking 1.7 2.5 3.9 -0.9 -1.6 -1.6 1.8 -2.0 1.2 1.8 1.0 1.1 1.9 -1.9
Ever had prostate specific antigen (PSA) test 1.6 1.9 3.7 1.2 1.9 1.7 0.5 1.2 -1.4 -1.2 -0.5 -1.9 -1.3 1.5
Fractured/broken bones in last 5 years 0.2 0.3 1.2 -0.5 -0.2 -0.9 0.0 -0.3 0.0 0.4 1.1 0.5 0.2 -0.3
Age started oral contraceptive pill 1.9 2.4 6.9 -1.9 -1.4 -1.7 0.9 -0.8 -1.7 -1.3 2.6 1.7 1.3 -0.3
Diastolic blood pressure, automated reading 0.1 0.4 1.7 0.8 -1.3 -0.4 1.2 -0.5 0.2 0.2 0.6 0.4 -0.3 -0.3
Ever depressed for a whole week 1.1 1.4 4.3 0.9 -0.0 -0.3 -2.1 0.0 1.9 1.8 -1.7 -0.2 -0.3 -0.6
Unable to work because of sickness or disability 0.5 0.6 2.5 0.6 1.6 0.9 -1.2 0.1 -0.6 -0.3 -0.0 -0.6 -0.5 0.6
Commuting to job workplace: Cycle 2.6 3.2 5.0 -2.0 -1.6 -2.2 1.2 -1.9 0.9 1.1 1.8 1.9 2.2 -2.1
Myopia 1.7 2.4 4.8 -0.5 -1.9 -1.6 0.7 -2.2 1.2 0.9 1.8 1.5 1.9 -1.9
Vascular/heart problems diagnosed by doctor 0.7 2.0 3.9 -2.0 -0.1 -1.9 0.4 -1.4 1.3 1.5 0.6 1.7 1.6 -1.5
Cholesterol lowering medication 1.1 1.7 2.9 1.7 1.3 1.5 -0.2 1.4 -0.5 -0.8 -1.4 -1.6 -1.6 1.3
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 1.8 1.4 1.1 1.2 -0.2 0.8 -0.4 -0.9 -0.9 -1.2 -1.2 0.9
Pain experienced in last month 2.0 3.4 7.3 -2.7 -1.7 -1.6 1.7 -1.9 -0.1 -0.1 2.4 2.2 2.3 -1.4
Supplements: Calcium 0.3 0.3 1.1 1.0 0.5 -0.1 0.2 -0.3 0.9 0.7 -0.2 -0.2 -0.2 -0.6
Basal cell carcinoma (self-reported) 3.2 3.8 8.0 0.6 1.5 2.1 -1.5 2.6 -2.1 -2.2 -1.3 -1.7 -1.9 2.8
Heart attack/myocardial infarction (self-reported) 1.9 2.5 5.7 1.8 0.8 2.4 0.4 1.6 0.2 -0.1 -2.2 -2.4 -1.6 1.4
Deep venous thrombosis (DVT) (self-reported) 0.9 1.2 2.3 -0.6 -1.4 -1.0 0.8 -1.1 1.3 1.5 0.6 0.9 1.1 -1.4
Heart disease (siblings) 0.5 0.7 2.0 -0.8 -0.3 0.4 0.6 1.0 -1.1 -1.4 0.0 -0.2 -0.7 1.2
Alcohol drinker status: Previous 3.4 3.9 6.0 1.0 1.2 2.4 -2.4 2.2 -1.8 -2.1 -1.6 -1.9 -2.0 2.4
Pack years of smoking 2.4 3.6 6.2 1.9 1.9 2.1 -1.8 2.2 -0.6 -0.6 -2.5 -2.0 -2.3 1.8
Impedance of whole body 0.4 2.2 9.1 -3.0 -1.5 -0.2 -1.1 0.8 -1.9 -1.8 1.3 0.9 0.7 1.1
Leg fat mass (left) 1.2 4.5 15.2 3.9 1.9 1.9 -0.3 0.9 1.9 1.5 -3.2 -2.4 -2.2 0.5
Arm predicted mass (left) 0.7 3.5 11.6 2.7 0.6 -0.6 0.1 -1.5 3.4 3.4 -1.1 -0.2 -0.1 -2.1