Best TWAS P=4.4e-20 · Best GWAS P=4.73e-18 conditioned to 0.754
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | METSIM | Adipose | CADM2 | 0.05 | 0.06 | lasso | 10 | 0.06 | 1.3e-09 | 6.4 | 6.0 | 1.9e-09 | 0.67 | 0.95 | 0.05 | FALSE |
2 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CADM2 | 0.06 | 0.00 | blup | 339 | 0.00 | 2.7e-01 | -6.3 | -8.3 | 9.9e-17 | -0.46 | 0.06 | 0.08 | FALSE |
3 | The Cancer Genome Atlas | Lung Adenocarcinoma | CADM2 | 0.08 | 0.04 | lasso | 4 | 0.05 | 2.1e-06 | 8.5 | 9.2 | 4.4e-20 | 0.93 | 0.04 | 0.96 | TRUE |
4 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CADM2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.0e-05 | 8.5 | 8.7 | 2.7e-18 | 0.94 | 0.04 | 0.95 | FALSE |
5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CADM2 | 0.14 | 0.05 | blup | 339 | 0.09 | 2.7e-04 | 8.6 | 6.7 | 2.5e-11 | 0.84 | 0.04 | 0.83 | FALSE |
6 | The Cancer Genome Atlas | Thyroid Carcinoma | CADM2 | 0.05 | 0.00 | blup | 339 | 0.02 | 3.2e-03 | 4.1 | 8.8 | 1.0e-18 | 0.67 | 0.04 | 0.54 | FALSE |