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chr3:51,616,334-53,778,875

Best TWAS P=1.16e-08 · Best GWAS P=3.32e-09 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	PPM1M	0.07	0.05	lasso	3	0.05	5.2e-05	4.4	-5.2	1.7e-07	-0.94	0.01	0.99	FALSE
2	GTEx	Artery Aorta	MUSTN1	0.15	0.14	lasso	6	0.11	9.5e-07	4.8	5.2	1.8e-07	0.68	0.42	0.57	FALSE
3	GTEx	Artery Coronary	ITIH4-AS1	0.11	0.12	enet	20	0.16	5.5e-06	4.6	5.4	8.0e-08	0.75	0.08	0.89	FALSE
4	GTEx	Brain Hippocampus	GLYCTK-AS1	0.17	0.25	lasso	6	0.15	1.9e-04	5.3	-5.7	1.3e-08	-0.86	0.04	0.92	FALSE
5	GTEx	Brain Nucleus accumbens basal ganglia	TMEM110	0.13	0.07	lasso	3	0.05	1.5e-02	5.4	5.3	1.1e-07	0.81	0.05	0.69	FALSE
6	GTEx	Liver	GNL3	0.14	0.02	lasso	5	0.04	3.0e-02	5.9	-5.3	1.2e-07	-0.87	0.03	0.78	FALSE
7	GTEx	Lung	GNL3	0.05	0.03	lasso	6	0.03	3.0e-03	5.5	-5.5	2.9e-08	-0.82	0.20	0.72	FALSE
8	GTEx	Pituitary	SFMBT1	0.16	0.01	enet	9	0.02	1.2e-01	5.3	5.5	4.6e-08	0.78	0.12	0.49	FALSE
9	GTEx	Prostate	NEK4	0.15	0.05	enet	19	0.07	8.9e-03	4.6	-5.2	1.8e-07	-0.50	0.12	0.53	FALSE
10	GTEx	Small Intestine Terminal Ileum	RP5-966M1.6	0.14	0.03	lasso	7	0.00	2.5e-01	5.3	5.4	5.4e-08	0.78	0.08	0.28	FALSE
11	GTEx	Stomach	RP5-966M1.6	0.15	0.20	enet	14	0.20	7.0e-10	4.6	5.4	8.3e-08	0.78	0.21	0.79	FALSE
12	GTEx	Testis	RP5-966M1.6	0.14	0.10	lasso	6	0.09	6.1e-05	4.8	5.3	1.1e-07	0.61	0.32	0.62	FALSE
13	GTEx	Whole Blood	SPCS1	0.03	0.02	lasso	3	0.02	4.6e-03	5.4	5.6	1.8e-08	0.87	0.05	0.94	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	GLT8D1	0.04	0.01	blup	362	0.04	4.8e-06	5.4	5.3	1.1e-07	0.73	0.13	0.83	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	ITIH4	0.08	0.09	blup	53	0.08	3.1e-05	5.0	5.2	1.9e-07	0.71	0.05	0.92	FALSE
16	The Cancer Genome Atlas	Glioblastoma Multiforme	ITIH4	0.10	0.02	blup	53	0.05	1.2e-02	4.6	5.3	9.4e-08	0.75	0.02	0.54	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ITIH4	0.06	0.06	blup	53	0.06	5.1e-07	4.9	5.4	7.6e-08	0.75	0.06	0.94	FALSE
18	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PPM1M	0.10	0.07	lasso	4	0.05	1.2e-03	5.7	-5.7	1.2e-08	-0.98	0.00	0.99	TRUE
19	The Cancer Genome Atlas	Rectum Adenocarcinoma	ITIH4	0.12	0.09	blup	53	0.06	1.4e-02	4.5	5.2	2.1e-07	0.77	0.02	0.58	FALSE